locus-tag	class	description
HEP85_RS00005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HEP85_RS00090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP85_RS00115	COG0596	Alpha beta hydrolase
HEP85_RS00155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP85_RS00200	COG1846	Transcriptional regulator
HEP85_RS00240	COG0604	alcohol dehydrogenase
HEP85_RS00315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP85_RS00490	COG0513	Belongs to the DEAD box helicase family
HEP85_RS00500	COG1959	2 iron, 2 sulfur cluster binding
HEP85_RS00525	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HEP85_RS00535	COG2197	response regulator
HEP85_RS00540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP85_RS00550	COG0662	Cupin 2, conserved barrel domain protein
HEP85_RS00555	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS00570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEP85_RS00575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP85_RS00640	COG2124	cytochrome p450
HEP85_RS00680	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP85_RS00685	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP85_RS00700	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP85_RS00720	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS00810	COG0604	alcohol dehydrogenase
HEP85_RS00810	COG3321	synthase
HEP85_RS00850	COG0604	alcohol dehydrogenase
HEP85_RS00850	COG3321	synthase
HEP85_RS00960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP85_RS00970	COG3320	Male sterility
HEP85_RS00970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP85_RS00980	COG3629	intracellular signal transduction
HEP85_RS00980	COG3903	Transcriptional regulator
HEP85_RS01005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS01005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS01035	COG0477	Major facilitator Superfamily
HEP85_RS01045	COG3387	PFAM Glycoside hydrolase 15-related
HEP85_RS01060	COG0583	DNA-binding transcription factor activity
HEP85_RS01065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP85_RS01085	COG2746	aminoglycoside 3-N-acetyltransferase activity
HEP85_RS01100	COG2850	peptidyl-arginine hydroxylation
HEP85_RS01255	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HEP85_RS01260	COG0477	Major facilitator Superfamily
HEP85_RS01285	COG1022	Amp-dependent synthetase and ligase
HEP85_RS01300	COG0667	Aldo Keto reductase
HEP85_RS01310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP85_RS01320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP85_RS01330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP85_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS01345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP85_RS01375	COG3739	integral membrane protein
HEP85_RS01420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP85_RS01505	COG2409	Drug exporters of the RND superfamily
HEP85_RS01515	COG0596	Alpha beta hydrolase
HEP85_RS01525	COG0640	Transcriptional regulator
HEP85_RS01530	COG0346	lactoylglutathione lyase activity
HEP85_RS01540	COG1073	alpha beta
HEP85_RS01550	COG0596	Alpha beta hydrolase
HEP85_RS01580	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS01600	COG2271	Major facilitator Superfamily
HEP85_RS01620	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS01655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS01755	COG4977	sequence-specific DNA binding
HEP85_RS01770	COG2124	cytochrome p450
HEP85_RS01775	COG1793	dna ligase
HEP85_RS01775	COG3285	dna ligase
HEP85_RS01830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP85_RS01885	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS01910	COG1309	transcriptional regulator
HEP85_RS01915	COG2755	lipolytic protein G-D-S-L family
HEP85_RS01915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP85_RS01965	COG0596	Alpha beta hydrolase
HEP85_RS01980	COG1309	transcriptional regulator
HEP85_RS02030	COG1309	transcriptional regulator
HEP85_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS02070	COG0596	Alpha beta hydrolase
HEP85_RS02075	COG3795	YCII-related domain
HEP85_RS02085	COG2208	phosphoserine phosphatase activity
HEP85_RS02085	COG2770	Histidine kinase
HEP85_RS02090	COG0596	Alpha beta hydrolase
HEP85_RS02115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP85_RS02120	COG1755	Isoprenylcysteine carboxyl methyltransferase
HEP85_RS02160	COG0477	Major facilitator Superfamily
HEP85_RS02165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP85_RS02180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP85_RS02190	COG0326	Molecular chaperone. Has ATPase activity
HEP85_RS02210	COG4221	oxidoreductase activity
HEP85_RS02215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HEP85_RS02220	COG1737	Transcriptional regulator
HEP85_RS02230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP85_RS02255	COG0747	negative chemotaxis
HEP85_RS02260	COG0601	transmembrane transport
HEP85_RS02265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP85_RS02270	COG0444	Belongs to the ABC transporter superfamily
HEP85_RS02280	COG1940	carbohydrate kinase activity
HEP85_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS02350	COG1104	cysteine desulfurase activity
HEP85_RS02360	COG3383	formate dehydrogenase (NAD+) activity
HEP85_RS02360	COG0243	molybdopterin cofactor binding
HEP85_RS02365	COG0437	4 iron, 4 sulfur cluster binding
HEP85_RS02390	COG0709	Synthesizes selenophosphate from selenide and ATP
HEP85_RS02410	COG0366	Alpha amylase catalytic
HEP85_RS02415	COG0673	inositol 2-dehydrogenase activity
HEP85_RS02425	COG0395	ABC-type sugar transport system, permease component
HEP85_RS02430	COG1175	transmembrane transport
HEP85_RS02440	COG1609	Transcriptional regulator
HEP85_RS02450	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP85_RS02455	COG1595	DNA-templated transcription, initiation
HEP85_RS02465	COG1404	Belongs to the peptidase S8 family
HEP85_RS02475	COG0667	Aldo Keto reductase
HEP85_RS02495	COG1132	(ABC) transporter
HEP85_RS02535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP85_RS02550	COG3250	beta-galactosidase activity
HEP85_RS02555	COG1609	Transcriptional regulator
HEP85_RS02570	COG0395	ABC-type sugar transport system, permease component
HEP85_RS02590	COG3773	Cell wall hydrolase
HEP85_RS02590	COG3409	Peptidoglycan-binding domain 1 protein
HEP85_RS02595	COG3540	Alkaline phosphatase
HEP85_RS02605	COG2070	2-Nitropropane dioxygenase
HEP85_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS02690	COG0028	Belongs to the TPP enzyme family
HEP85_RS02695	COG0069	glutamate synthase activity
HEP85_RS02715	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP85_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS02750	COG1959	2 iron, 2 sulfur cluster binding
HEP85_RS02760	COG1902	pentaerythritol trinitrate reductase activity
HEP85_RS02775	COG1309	transcriptional regulator
HEP85_RS02780	COG1959	2 iron, 2 sulfur cluster binding
HEP85_RS02785	COG1595	DNA-templated transcription, initiation
HEP85_RS02820	COG2340	Cysteine-rich secretory protein family
HEP85_RS02830	COG4221	oxidoreductase activity
HEP85_RS02835	COG0583	DNA-binding transcription factor activity
HEP85_RS02870	COG2197	response regulator
HEP85_RS02890	COG3537	Alpha-1,2-mannosidase
HEP85_RS02905	COG2197	response regulator
HEP85_RS02945	COG4106	trans-aconitate 2-methyltransferase activity
HEP85_RS02950	COG3250	beta-galactosidase activity
HEP85_RS02970	COG0574	Belongs to the PEP-utilizing enzyme family
HEP85_RS02970	COG3848	Pyruvate phosphate dikinase
HEP85_RS02980	COG0778	Nitroreductase
HEP85_RS03010	COG3485	protocatechuate 3,4-dioxygenase
HEP85_RS03030	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS03070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP85_RS03075	COG0366	Alpha amylase catalytic
HEP85_RS03080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS03100	COG2207	Transcriptional regulator
HEP85_RS03130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP85_RS03150	COG3469	chitinase activity
HEP85_RS03180	COG4585	Histidine kinase
HEP85_RS03185	COG2197	response regulator
HEP85_RS03220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP85_RS03255	COG3851	Histidine kinase
HEP85_RS03260	COG2197	response regulator
HEP85_RS03265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP85_RS03285	COG1309	transcriptional regulator
HEP85_RS03315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP85_RS03375	COG3250	beta-galactosidase activity
HEP85_RS03395	COG1316	TRANSCRIPTIONal
HEP85_RS03400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP85_RS03430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HEP85_RS03440	COG0477	Major facilitator Superfamily
HEP85_RS03445	COG1846	Transcriptional regulator
HEP85_RS03470	COG1278	Cold shock
HEP85_RS03500	COG0137	argininosuccinate synthase activity
HEP85_RS03525	COG0596	Alpha beta hydrolase
HEP85_RS03540	COG0667	Aldo Keto reductase
HEP85_RS03550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP85_RS03555	COG0583	DNA-binding transcription factor activity
HEP85_RS03560	COG2814	Major facilitator Superfamily
HEP85_RS03620	COG0277	FAD linked oxidase domain protein
HEP85_RS03640	COG0366	Alpha amylase catalytic
HEP85_RS03645	COG0366	Alpha amylase catalytic
HEP85_RS03650	COG3281	Trehalose synthase
HEP85_RS03665	COG0842	Transport permease protein
HEP85_RS03675	COG1846	Transcriptional regulator
HEP85_RS03685	COG0477	Major facilitator Superfamily
HEP85_RS03710	COG0494	nUDIX hydrolase
HEP85_RS03755	COG3345	alpha-galactosidase
HEP85_RS03760	COG0395	ABC-type sugar transport system, permease component
HEP85_RS03765	COG1175	transmembrane transport
HEP85_RS03775	COG1940	carbohydrate kinase activity
HEP85_RS03775	COG1846	Transcriptional regulator
HEP85_RS03795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP85_RS03805	COG0431	NADPH-dependent FMN reductase
HEP85_RS03855	COG2304	oxidoreductase activity
HEP85_RS03860	COG0328	RNA-DNA hybrid ribonuclease activity
HEP85_RS03880	COG0583	DNA-binding transcription factor activity
HEP85_RS03910	COG0596	Alpha beta hydrolase
HEP85_RS03915	COG0740	serine-type endopeptidase activity
HEP85_RS03920	COG0740	serine-type endopeptidase activity
HEP85_RS03925	COG1396	sequence-specific DNA binding
HEP85_RS03935	COG2318	DinB family
HEP85_RS03945	COG0784	Response regulator, receiver
HEP85_RS03950	COG4251	negative regulation of phosphorylation
HEP85_RS04015	COG2207	Transcriptional regulator
HEP85_RS04025	COG0667	Aldo Keto reductase
HEP85_RS04045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP85_RS04050	COG0346	lactoylglutathione lyase activity
HEP85_RS04055	COG0671	phosphoesterase, PA-phosphatase related
HEP85_RS04065	COG0412	Dienelactone hydrolase
HEP85_RS04070	COG0667	Aldo Keto reductase
HEP85_RS04080	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS04090	COG4941	Belongs to the sigma-70 factor family
HEP85_RS04095	COG3795	YCII-related domain
HEP85_RS04105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS04115	COG0431	NADPH-dependent FMN reductase
HEP85_RS04145	COG0702	epimerase
HEP85_RS04170	COG1595	DNA-templated transcription, initiation
HEP85_RS04185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP85_RS04190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP85_RS04260	COG0739	heme binding
HEP85_RS04260	COG0741	lytic transglycosylase activity
HEP85_RS04260	COG1196	nuclear chromosome segregation
HEP85_RS04280	COG1940	carbohydrate kinase activity
HEP85_RS04285	COG3250	beta-galactosidase activity
HEP85_RS04315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP85_RS04340	COG0367	asparagine synthase
HEP85_RS04345	COG0069	glutamate synthase activity
HEP85_RS04360	COG3511	phospholipase C
HEP85_RS04410	COG1942	4-Oxalocrotonate Tautomerase
HEP85_RS04425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP85_RS04435	COG0473	3-isopropylmalate dehydrogenase activity
HEP85_RS04435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP85_RS04440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP85_RS04485	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS04510	COG2070	2-Nitropropane dioxygenase
HEP85_RS04530	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS04560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP85_RS04575	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS04585	COG2376	Dihydroxyacetone kinase
HEP85_RS04590	COG1461	Dihydroxyacetone kinase
HEP85_RS04620	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP85_RS04620	COG1902	pentaerythritol trinitrate reductase activity
HEP85_RS04625	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP85_RS04640	COG0456	acetyltransferase
HEP85_RS04650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP85_RS04670	COG3458	cephalosporin-C deacetylase activity
HEP85_RS04695	COG2409	Drug exporters of the RND superfamily
HEP85_RS04700	COG0745	RESPONSE REGULATOR receiver
HEP85_RS04705	COG2205	protein histidine kinase activity
HEP85_RS04710	COG0604	alcohol dehydrogenase
HEP85_RS04725	COG0366	Alpha amylase catalytic
HEP85_RS04730	COG4941	Belongs to the sigma-70 factor family
HEP85_RS04740	COG3795	YCII-related domain
HEP85_RS04755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP85_RS04770	COG2066	Belongs to the glutaminase family
HEP85_RS04775	COG1968	undecaprenyl-diphosphatase activity
HEP85_RS04780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP85_RS04785	COG1993	acr, cog1993
HEP85_RS04790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP85_RS04875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP85_RS04905	COG4335	DNA alkylation repair
HEP85_RS04920	COG0300	oxidoreductase activity
HEP85_RS04940	COG2318	DinB family
HEP85_RS04955	COG4221	oxidoreductase activity
HEP85_RS04960	COG1132	(ABC) transporter
HEP85_RS04965	COG2274	protein secretion by the type I secretion system
HEP85_RS04985	COG1408	metallophosphoesterase
HEP85_RS05000	COG1716	ATPase activity
HEP85_RS05010	COG0477	Major facilitator Superfamily
HEP85_RS05030	COG1309	transcriptional regulator
HEP85_RS05050	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP85_RS05055	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEP85_RS05060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP85_RS05070	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP85_RS05095	COG1902	pentaerythritol trinitrate reductase activity
HEP85_RS05105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP85_RS05115	COG2376	Dihydroxyacetone kinase
HEP85_RS05135	COG3629	intracellular signal transduction
HEP85_RS05135	COG3903	Transcriptional regulator
HEP85_RS05145	COG0612	Peptidase, M16
HEP85_RS05165	COG4555	ABC transporter
HEP85_RS05200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP85_RS05250	COG2267	carboxylic ester hydrolase activity
HEP85_RS05260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP85_RS05300	COG0842	Transport permease protein
HEP85_RS05445	COG1175	transmembrane transport
HEP85_RS05450	COG0395	ABC-type sugar transport system, permease component
HEP85_RS05465	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS05495	COG1215	transferase activity, transferring glycosyl groups
HEP85_RS05510	COG0633	Ferredoxin
HEP85_RS05510	COG3217	Mosc domain protein beta barrel domain protein
HEP85_RS05530	COG1349	DNA-binding transcription factor activity
HEP85_RS05560	COG1136	(ABC) transporter
HEP85_RS05595	COG2813	Specifically methylates the guanine in position
HEP85_RS05605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP85_RS05610	COG1349	DNA-binding transcription factor activity
HEP85_RS05615	COG3537	Alpha-1,2-mannosidase
HEP85_RS05625	COG1174	glycine betaine transport
HEP85_RS05645	COG2018	Roadblock/LC7 domain
HEP85_RS05660	COG2986	histidine ammonia-lyase
HEP85_RS05670	COG2267	carboxylic ester hydrolase activity
HEP85_RS05680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP85_RS05680	COG3320	Male sterility
HEP85_RS05735	COG2197	response regulator
HEP85_RS05755	COG0445	tRNA wobble uridine modification
HEP85_RS05760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP85_RS05765	COG1660	Displays ATPase and GTPase activities
HEP85_RS05785	COG3345	alpha-galactosidase
HEP85_RS05810	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEP85_RS05835	COG0204	Acyl-transferase
HEP85_RS05865	COG0584	glycerophosphoryl diester phosphodiesterase
HEP85_RS05910	COG1309	transcriptional regulator
HEP85_RS05935	COG2233	PERMEase
HEP85_RS05940	COG0640	Transcriptional regulator
HEP85_RS05945	COG1902	pentaerythritol trinitrate reductase activity
HEP85_RS05965	COG4221	oxidoreductase activity
HEP85_RS05985	COG1595	DNA-templated transcription, initiation
HEP85_RS05995	COG1764	response to oxidative stress
HEP85_RS06000	COG1053	succinate dehydrogenase
HEP85_RS06010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP85_RS06035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP85_RS06035	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP85_RS06050	COG0640	Transcriptional regulator
HEP85_RS06080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP85_RS06090	COG2706	6-phosphogluconolactonase activity
HEP85_RS06095	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HEP85_RS06140	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HEP85_RS06145	COG2326	polyphosphate kinase activity
HEP85_RS06180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP85_RS06185	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP85_RS06205	COG2770	Histidine kinase
HEP85_RS06205	COG2208	phosphoserine phosphatase activity
HEP85_RS06225	COG0745	RESPONSE REGULATOR receiver
HEP85_RS06270	COG0432	Pfam Uncharacterised protein family UPF0047
HEP85_RS06275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP85_RS06280	COG1116	anion transmembrane transporter activity
HEP85_RS06290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS06305	COG1132	(ABC) transporter
HEP85_RS06325	COG1132	(ABC) transporter
HEP85_RS06330	COG1132	(ABC) transporter
HEP85_RS06340	COG0254	rRNA binding
HEP85_RS06355	COG1946	Acyl-CoA thioesterase
HEP85_RS06365	COG2018	Roadblock/LC7 domain
HEP85_RS06385	COG2018	Roadblock/LC7 domain
HEP85_RS06435	COG3239	Fatty acid desaturase
HEP85_RS06455	COG2115	Belongs to the xylose isomerase family
HEP85_RS06460	COG1070	Carbohydrate kinase
HEP85_RS06465	COG1940	carbohydrate kinase activity
HEP85_RS06470	COG1113	amino acid transport
HEP85_RS06485	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS06530	COG0494	nUDIX hydrolase
HEP85_RS06555	COG1414	Transcriptional regulator
HEP85_RS06575	COG3963	phosphatidate phosphatase activity
HEP85_RS06580	COG3851	Histidine kinase
HEP85_RS06585	COG2197	response regulator
HEP85_RS06605	COG0726	polysaccharide deacetylase
HEP85_RS06615	COG0745	RESPONSE REGULATOR receiver
HEP85_RS06635	COG0739	heme binding
HEP85_RS06640	COG2808	Putative FMN-binding domain
HEP85_RS06685	COG0477	Major facilitator Superfamily
HEP85_RS06715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEP85_RS06735	COG1846	Transcriptional regulator
HEP85_RS06790	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS06795	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS06815	COG1793	dna ligase
HEP85_RS06840	COG3424	synthase
HEP85_RS06845	COG2124	cytochrome p450
HEP85_RS06855	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS06865	COG0242	peptide deformylase activity
HEP85_RS06875	COG3442	glutamine amidotransferase
HEP85_RS06880	COG0205	6-phosphofructokinase activity
HEP85_RS06895	COG3275	phosphorelay sensor kinase activity
HEP85_RS06900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP85_RS06920	COG1834	amidinotransferase
HEP85_RS06925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP85_RS06930	COG0204	Acyl-transferase
HEP85_RS06940	COG0829	nickel cation binding
HEP85_RS06945	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEP85_RS06955	COG0804	urea catabolic process
HEP85_RS06960	COG0832	Belongs to the urease beta subunit family
HEP85_RS06965	COG0831	urea catabolic process
HEP85_RS06975	COG0740	serine-type endopeptidase activity
HEP85_RS06995	COG0583	DNA-binding transcription factor activity
HEP85_RS07020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP85_RS07025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP85_RS07030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEP85_RS07035	COG2226	methyltransferase
HEP85_RS07055	COG1136	(ABC) transporter
HEP85_RS07055	COG0577	efflux transmembrane transporter activity
HEP85_RS07085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEP85_RS07090	COG3663	DNA glycosylase
HEP85_RS07105	COG4585	Histidine kinase
HEP85_RS07110	COG2197	response regulator
HEP85_RS07115	COG1940	carbohydrate kinase activity
HEP85_RS07120	COG2188	Transcriptional regulator
HEP85_RS07125	COG1595	DNA-templated transcription, initiation
HEP85_RS07175	COG1522	sequence-specific DNA binding
HEP85_RS07190	COG0420	3'-5' exonuclease activity
HEP85_RS07195	COG1739	Uncharacterized protein family UPF0029
HEP85_RS07225	COG1832	CoA-binding protein
HEP85_RS07255	COG0110	maltose O-acetyltransferase activity
HEP85_RS07270	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HEP85_RS07295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP85_RS07305	COG0183	Belongs to the thiolase family
HEP85_RS07330	COG1968	undecaprenyl-diphosphatase activity
HEP85_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS07360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS07370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HEP85_RS07390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP85_RS07395	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP85_RS07405	COG1024	Enoyl-CoA hydratase
HEP85_RS07455	COG0596	Alpha beta hydrolase
HEP85_RS07480	COG0697	spore germination
HEP85_RS07510	COG1695	Transcriptional regulator
HEP85_RS07515	COG0384	phenazine biosynthesis protein PhzF
HEP85_RS07545	COG0739	heme binding
HEP85_RS07550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP85_RS07550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP85_RS07560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP85_RS07580	COG1716	ATPase activity
HEP85_RS07600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP85_RS07630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP85_RS07640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP85_RS07660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP85_RS07670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP85_RS07675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP85_RS07695	COG2018	Roadblock/LC7 domain
HEP85_RS07715	COG2146	nitrite reductase [NAD(P)H] activity
HEP85_RS07720	COG1414	Transcriptional regulator
HEP85_RS07735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP85_RS07745	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS07780	COG2814	Major facilitator Superfamily
HEP85_RS07790	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HEP85_RS07810	COG0438	transferase activity, transferring glycosyl groups
HEP85_RS07815	COG0438	transferase activity, transferring glycosyl groups
HEP85_RS07855	COG2270	Major facilitator Superfamily
HEP85_RS07870	COG0463	Glycosyl transferase, family 2
HEP85_RS07900	COG1309	transcriptional regulator
HEP85_RS07945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP85_RS07950	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP85_RS07955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP85_RS07965	COG3201	nicotinamide mononucleotide transporter
HEP85_RS07980	COG2223	nitrite transmembrane transporter activity
HEP85_RS07995	COG2233	PERMEase
HEP85_RS08015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP85_RS08025	COG3842	ATPase activity
HEP85_RS08045	COG2188	Transcriptional regulator
HEP85_RS08055	COG0531	amino acid
HEP85_RS08075	COG2390	Transcriptional regulator
HEP85_RS08080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEP85_RS08105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP85_RS08120	COG0194	GDP metabolic process
HEP85_RS08130	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP85_RS08135	COG0167	dihydroorotate dehydrogenase activity
HEP85_RS08140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP85_RS08145	COG0505	Belongs to the CarA family
HEP85_RS08155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP85_RS08160	COG0540	Belongs to the ATCase OTCase family
HEP85_RS08165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HEP85_RS08175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP85_RS08180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP85_RS08185	COG0006	proline dipeptidase activity
HEP85_RS08195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEP85_RS08200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP85_RS08205	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEP85_RS08215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP85_RS08220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP85_RS08225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP85_RS08245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP85_RS08265	COG0124	histidyl-tRNA synthetase
HEP85_RS08275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP85_RS08280	COG1196	nuclear chromosome segregation
HEP85_RS08285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP85_RS08290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HEP85_RS08295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP85_RS08300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP85_RS08310	COG2255	four-way junction helicase activity
HEP85_RS08315	COG0632	four-way junction helicase activity
HEP85_RS08320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HEP85_RS08325	COG0217	transcriptional regulatory protein
HEP85_RS08330	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HEP85_RS08335	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HEP85_RS08345	COG0438	transferase activity, transferring glycosyl groups
HEP85_RS08350	COG1560	Kdo2-lipid A biosynthetic process
HEP85_RS08355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP85_RS08375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP85_RS08380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEP85_RS08395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP85_RS08455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP85_RS08515	COG1648	precorrin-2 dehydrogenase activity
HEP85_RS08515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP85_RS08535	COG1464	Belongs to the NlpA lipoprotein family
HEP85_RS08540	COG2011	ABC-type metal ion transport system permease component
HEP85_RS08545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP85_RS08580	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS08580	COG0204	Acyl-transferase
HEP85_RS08585	COG0477	Major facilitator Superfamily
HEP85_RS08600	COG0165	Argininosuccinate lyase
HEP85_RS08605	COG0137	argininosuccinate synthase activity
HEP85_RS08635	COG1438	arginine binding
HEP85_RS08640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP85_RS08645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP85_RS08650	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEP85_RS08655	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP85_RS08695	COG0697	spore germination
HEP85_RS08705	COG1649	PFAM Uncharacterised BCR, COG1649
HEP85_RS08745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP85_RS08750	COG5002	protein histidine kinase activity
HEP85_RS08755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP85_RS08760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP85_RS08765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HEP85_RS08770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP85_RS08830	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS08835	COG0174	glutamine synthetase
HEP85_RS08865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEP85_RS08875	COG4176	ABC-type proline glycine betaine transport system permease component
HEP85_RS08880	COG4175	Glycine betaine
HEP85_RS08880	COG0517	IMP dehydrogenase activity
HEP85_RS08885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP85_RS08895	COG0564	pseudouridine synthase activity
HEP85_RS08925	COG1309	transcriptional regulator
HEP85_RS08960	COG0805	protein transport
HEP85_RS08965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP85_RS08995	COG0545	Peptidyl-prolyl cis-trans isomerase
HEP85_RS09000	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP85_RS09010	COG1609	Transcriptional regulator
HEP85_RS09015	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP85_RS09020	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP85_RS09035	COG4122	O-methyltransferase activity
HEP85_RS09040	COG1222	aaa ATPase
HEP85_RS09065	COG1994	Peptidase M50
HEP85_RS09065	COG0517	IMP dehydrogenase activity
HEP85_RS09075	COG2197	response regulator
HEP85_RS09080	COG4166	transmembrane transport
HEP85_RS09090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP85_RS09095	COG0646	methionine synthase
HEP85_RS09095	COG1410	methionine synthase
HEP85_RS09100	COG1414	Transcriptional regulator
HEP85_RS09105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP85_RS09110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP85_RS09115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEP85_RS09120	COG2186	Transcriptional regulator
HEP85_RS09130	COG1404	Belongs to the peptidase S8 family
HEP85_RS09140	COG0215	cysteine-tRNA ligase activity
HEP85_RS09160	COG0598	Magnesium transport protein CorA
HEP85_RS09170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS09175	COG0667	Aldo Keto reductase
HEP85_RS09205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP85_RS09220	COG0308	aminopeptidase N
HEP85_RS09225	COG3012	SEC-C Motif Domain Protein
HEP85_RS09230	COG2186	Transcriptional regulator
HEP85_RS09235	COG3265	gluconokinase activity
HEP85_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS09275	COG3573	Dehydrogenase
HEP85_RS09285	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP85_RS09290	COG2149	membrane
HEP85_RS09320	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS09330	COG3876	Protein conserved in bacteria
HEP85_RS09355	COG0789	Transcriptional regulator
HEP85_RS09375	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS09385	COG0640	Transcriptional regulator
HEP85_RS09420	COG0243	molybdopterin cofactor binding
HEP85_RS09425	COG1309	transcriptional regulator
HEP85_RS09435	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP85_RS09440	COG2188	Transcriptional regulator
HEP85_RS09460	COG1595	DNA-templated transcription, initiation
HEP85_RS09485	COG2815	serine threonine protein kinase
HEP85_RS09485	COG0515	serine threonine protein kinase
HEP85_RS09490	COG2755	lipolytic protein G-D-S-L family
HEP85_RS09505	COG0463	Glycosyl transferase, family 2
HEP85_RS09510	COG1216	Glycosyl transferase, family 2
HEP85_RS09515	COG0726	polysaccharide deacetylase
HEP85_RS09535	COG1725	Transcriptional regulator
HEP85_RS09570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEP85_RS09570	COG0662	Cupin 2, conserved barrel domain protein
HEP85_RS09580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP85_RS09590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP85_RS09605	COG0330	HflC and HflK could
HEP85_RS09645	COG1799	cell septum assembly
HEP85_RS09655	COG0477	Major facilitator Superfamily
HEP85_RS09665	COG0671	phosphoesterase, PA-phosphatase related
HEP85_RS09700	COG1160	GTP binding
HEP85_RS09710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP85_RS09750	COG3541	Predicted nucleotidyltransferase
HEP85_RS09770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP85_RS09790	COG0686	Belongs to the AlaDH PNT family
HEP85_RS09800	COG0494	nUDIX hydrolase
HEP85_RS09805	COG0504	CTP synthase activity
HEP85_RS09810	COG3387	PFAM Glycoside hydrolase 15-related
HEP85_RS09835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEP85_RS09855	COG1120	ATPase activity
HEP85_RS09860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP85_RS09865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP85_RS09905	COG2094	Belongs to the DNA glycosylase MPG family
HEP85_RS09915	COG1881	PFAM PEBP family protein
HEP85_RS09935	COG1119	ATPase activity
HEP85_RS09955	COG2197	response regulator
HEP85_RS09970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP85_RS09980	COG1716	ATPase activity
HEP85_RS09980	COG1131	(ABC) transporter
HEP85_RS09980	COG0842	Transport permease protein
HEP85_RS09990	COG3830	Belongs to the UPF0237 family
HEP85_RS09990	COG0560	Phosphoserine phosphatase
HEP85_RS09995	COG0588	phosphoglycerate mutase activity
HEP85_RS10010	COG2186	Transcriptional regulator
HEP85_RS10025	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS10040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP85_RS10060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP85_RS10065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP85_RS10090	COG1063	alcohol dehydrogenase
HEP85_RS10135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP85_RS10150	COG3387	PFAM Glycoside hydrolase 15-related
HEP85_RS10195	COG1024	Enoyl-CoA hydratase
HEP85_RS10205	COG0488	(ABC) transporter
HEP85_RS10235	COG0235	Class ii aldolase
HEP85_RS10255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HEP85_RS10260	COG1492	cobalamin metabolic process
HEP85_RS10275	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HEP85_RS10280	COG1797	cobyrinic acid a,c-diamide synthase activity
HEP85_RS10340	COG0765	amino acid transport
HEP85_RS10345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP85_RS10365	COG0456	acetyltransferase
HEP85_RS10370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP85_RS10375	COG1917	Cupin 2, conserved barrel domain protein
HEP85_RS10380	COG5285	phytanoyl-CoA dioxygenase
HEP85_RS10410	COG1414	Transcriptional regulator
HEP85_RS10420	COG0768	penicillin binding
HEP85_RS10425	COG2252	PERMEase
HEP85_RS10455	COG4677	pectinesterase activity
HEP85_RS10465	COG1653	transport
HEP85_RS10485	COG0395	ABC-type sugar transport system, permease component
HEP85_RS10500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP85_RS10505	COG1802	Transcriptional regulator
HEP85_RS10525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP85_RS10530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP85_RS10535	COG1349	DNA-binding transcription factor activity
HEP85_RS10550	COG0395	ABC-type sugar transport system, permease component
HEP85_RS10555	COG1063	alcohol dehydrogenase
HEP85_RS10565	COG1309	transcriptional regulator
HEP85_RS10620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP85_RS10630	COG1595	DNA-templated transcription, initiation
HEP85_RS10660	COG2171	N-acyltransferase activity
HEP85_RS10665	COG3226	Transcriptional regulator
HEP85_RS10670	COG2076	Multidrug Resistance protein
HEP85_RS10685	COG0822	iron-sulfur transferase activity
HEP85_RS10690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP85_RS10695	COG0396	ATPase activity
HEP85_RS10705	COG0719	Fe-S assembly protein
HEP85_RS10720	COG2746	aminoglycoside 3-N-acetyltransferase activity
HEP85_RS10725	COG1131	(ABC) transporter
HEP85_RS10735	COG1612	heme a metabolic process
HEP85_RS10755	COG0109	protoheme IX farnesyltransferase activity
HEP85_RS10765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP85_RS10785	COG0166	Belongs to the GPI family
HEP85_RS10800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEP85_RS10805	COG0149	triose-phosphate isomerase activity
HEP85_RS10810	COG0126	phosphoglycerate kinase activity
HEP85_RS10815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP85_RS10825	COG1481	regulation of sporulation
HEP85_RS10830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEP85_RS10835	COG1660	Displays ATPase and GTPase activities
HEP85_RS10840	COG0322	excinuclease ABC activity
HEP85_RS10865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP85_RS10875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP85_RS10880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP85_RS10885	COG0765	amino acid transport
HEP85_RS10895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP85_RS10900	COG0477	Major facilitator Superfamily
HEP85_RS10905	COG0387	Pfam Sodium calcium exchanger
HEP85_RS10925	COG0556	nucleotide-excision repair
HEP85_RS10935	COG0584	glycerophosphoryl diester phosphodiesterase
HEP85_RS10940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP85_RS10955	COG1063	alcohol dehydrogenase
HEP85_RS10965	COG2313	pseudouridylate synthase activity
HEP85_RS10975	COG2226	methyltransferase
HEP85_RS10980	COG0598	Magnesium transport protein CorA
HEP85_RS11075	COG0251	oxidation-reduction process
HEP85_RS11095	COG2267	carboxylic ester hydrolase activity
HEP85_RS11135	COG0237	dephospho-CoA kinase activity
HEP85_RS11160	COG2226	methyltransferase
HEP85_RS11205	COG2050	protein possibly involved in aromatic compounds catabolism
HEP85_RS11260	COG0737	Belongs to the 5'-nucleotidase family
HEP85_RS11280	COG1605	Chorismate mutase
HEP85_RS11280	COG0287	Prephenate dehydrogenase
HEP85_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS11320	COG1024	Enoyl-CoA hydratase
HEP85_RS11340	COG0183	Belongs to the thiolase family
HEP85_RS11345	COG1309	transcriptional regulator
HEP85_RS11355	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS11390	COG0070	glutamate synthase
HEP85_RS11390	COG0067	glutamate synthase
HEP85_RS11390	COG0069	glutamate synthase activity
HEP85_RS11425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP85_RS11430	COG2301	Belongs to the HpcH HpaI aldolase family
HEP85_RS11445	COG0159	tryptophan synthase activity
HEP85_RS11450	COG0133	tryptophan synthase activity
HEP85_RS11460	COG0134	indole-3-glycerol-phosphate synthase activity
HEP85_RS11485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP85_RS11495	COG0107	imidazoleglycerol-phosphate synthase activity
HEP85_RS11500	COG0251	oxidation-reduction process
HEP85_RS11505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HEP85_RS11510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP85_RS11520	COG0131	Imidazoleglycerol-phosphate dehydratase
HEP85_RS11525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP85_RS11530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP85_RS11550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEP85_RS11570	COG1432	Conserved Protein
HEP85_RS11580	COG0587	DNA-directed DNA polymerase activity
HEP85_RS11630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEP85_RS11645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HEP85_RS11650	COG3599	regulation of cell shape
HEP85_RS11660	COG1799	cell septum assembly
HEP85_RS11675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP85_RS11685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP85_RS11695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEP85_RS11700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP85_RS11710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEP85_RS11725	COG0275	rRNA processing
HEP85_RS11735	COG0714	Associated with various cellular activities
HEP85_RS11755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP85_RS11765	COG1716	ATPase activity
HEP85_RS11765	COG1131	(ABC) transporter
HEP85_RS11765	COG0842	Transport permease protein
HEP85_RS11775	COG1309	transcriptional regulator
HEP85_RS11815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP85_RS11815	COG2022	thiamine diphosphate biosynthetic process
HEP85_RS11825	COG2022	thiamine diphosphate biosynthetic process
HEP85_RS11830	COG0515	serine threonine protein kinase
HEP85_RS11830	COG2815	serine threonine protein kinase
HEP85_RS11835	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HEP85_RS11840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP85_RS11845	COG2193	ferroxidase activity
HEP85_RS11855	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP85_RS11870	COG0205	6-phosphofructokinase activity
HEP85_RS11905	COG1940	carbohydrate kinase activity
HEP85_RS11990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP85_RS11995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP85_RS12000	COG0723	plastoquinol--plastocyanin reductase activity
HEP85_RS12005	COG2010	Cytochrome c
HEP85_RS12010	COG1845	cytochrome c oxidase, subunit III
HEP85_RS12020	COG1376	ErfK ybiS ycfS ynhG family protein
HEP85_RS12030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP85_RS12035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP85_RS12045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP85_RS12065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HEP85_RS12070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP85_RS12075	COG2197	response regulator
HEP85_RS12100	COG2226	methyltransferase
HEP85_RS12120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HEP85_RS12125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP85_RS12125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP85_RS12140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HEP85_RS12145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP85_RS12150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP85_RS12165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEP85_RS12185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP85_RS12210	COG0321	lipoyl(octanoyl) transferase activity
HEP85_RS12215	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP85_RS12235	COG0174	glutamine synthetase
HEP85_RS12240	COG0501	Belongs to the peptidase M48B family
HEP85_RS12290	COG0745	RESPONSE REGULATOR receiver
HEP85_RS12330	COG1309	transcriptional regulator
HEP85_RS12355	COG0366	Alpha amylase catalytic
HEP85_RS12360	COG3833	ABC-type maltose transport systems, permease component
HEP85_RS12365	COG1175	transmembrane transport
HEP85_RS12375	COG1609	Transcriptional regulator
HEP85_RS12385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP85_RS12395	COG3511	phospholipase C
HEP85_RS12420	COG0477	Major facilitator Superfamily
HEP85_RS12445	COG2267	carboxylic ester hydrolase activity
HEP85_RS12455	COG0174	glutamine synthetase
HEP85_RS12460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP85_RS12460	COG1017	nitric oxide dioxygenase activity
HEP85_RS12465	COG1959	2 iron, 2 sulfur cluster binding
HEP85_RS12490	COG2814	Major facilitator Superfamily
HEP85_RS12505	COG0477	Major facilitator Superfamily
HEP85_RS12510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP85_RS12530	COG1994	Peptidase M50
HEP85_RS12585	COG2822	iron ion transport
HEP85_RS12595	COG0672	)-iron permease
HEP85_RS12605	COG0495	leucyl-tRNA aminoacylation
HEP85_RS12615	COG1834	amidinotransferase
HEP85_RS12625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP85_RS12630	COG2814	Major facilitator Superfamily
HEP85_RS12655	COG1136	(ABC) transporter
HEP85_RS12675	COG0406	alpha-ribazole phosphatase activity
HEP85_RS12690	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS12695	COG0673	inositol 2-dehydrogenase activity
HEP85_RS12725	COG0739	heme binding
HEP85_RS12725	COG0741	lytic transglycosylase activity
HEP85_RS12725	COG1196	nuclear chromosome segregation
HEP85_RS12770	COG0800	Aldolase
HEP85_RS12785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HEP85_RS12795	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS12805	COG2030	dehydratase
HEP85_RS12810	COG1131	(ABC) transporter
HEP85_RS12820	COG4585	Histidine kinase
HEP85_RS12825	COG2197	response regulator
HEP85_RS12840	COG0183	Belongs to the thiolase family
HEP85_RS12845	COG0477	Major facilitator Superfamily
HEP85_RS12865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS12895	COG1309	transcriptional regulator
HEP85_RS12950	COG3619	membrane
HEP85_RS12960	COG0183	Belongs to the thiolase family
HEP85_RS12965	COG2124	cytochrome p450
HEP85_RS12980	COG4122	O-methyltransferase activity
HEP85_RS13060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP85_RS13070	COG1335	isochorismatase
HEP85_RS13125	COG2124	cytochrome p450
HEP85_RS13215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP85_RS13265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP85_RS13325	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEP85_RS13330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP85_RS13335	COG0477	Major facilitator Superfamily
HEP85_RS13340	COG1309	transcriptional regulator
HEP85_RS13355	COG0667	Aldo Keto reductase
HEP85_RS13360	COG0789	Transcriptional regulator
HEP85_RS13375	COG1741	Belongs to the pirin family
HEP85_RS13390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP85_RS13395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP85_RS13400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP85_RS13425	COG1309	transcriptional regulator
HEP85_RS13440	COG2084	Dehydrogenase
HEP85_RS13470	COG1764	response to oxidative stress
HEP85_RS13475	COG2130	NADP-dependent
HEP85_RS13490	COG4948	Mandelate Racemase Muconate Lactonizing
HEP85_RS13530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP85_RS13560	COG1414	Transcriptional regulator
HEP85_RS13585	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS13595	COG1077	Cell shape determining protein MreB Mrl
HEP85_RS13630	COG1070	Carbohydrate kinase
HEP85_RS13645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP85_RS13650	COG0358	DNA primase activity
HEP85_RS13660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HEP85_RS13670	COG2949	membrane
HEP85_RS13715	COG1309	transcriptional regulator
HEP85_RS13720	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS13730	COG0574	Belongs to the PEP-utilizing enzyme family
HEP85_RS13730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP85_RS13735	COG1940	carbohydrate kinase activity
HEP85_RS13735	COG1846	Transcriptional regulator
HEP85_RS13770	COG0477	Major facilitator Superfamily
HEP85_RS13795	COG0667	Aldo Keto reductase
HEP85_RS13805	COG0423	glycine-tRNA ligase activity
HEP85_RS13810	COG3443	Belongs to the bacterial solute-binding protein 9 family
HEP85_RS13810	COG0803	Belongs to the bacterial solute-binding protein 9 family
HEP85_RS13815	COG1121	(ABC) transporter
HEP85_RS13820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEP85_RS13835	COG1381	Involved in DNA repair and RecF pathway recombination
HEP85_RS13855	COG2186	Transcriptional regulator
HEP85_RS13860	COG0747	negative chemotaxis
HEP85_RS13870	COG0444	Belongs to the ABC transporter superfamily
HEP85_RS13880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP85_RS13895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP85_RS13915	COG2723	6-phospho-beta-galactosidase activity
HEP85_RS13950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP85_RS13960	COG2315	Protein conserved in bacteria
HEP85_RS13970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEP85_RS13990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP85_RS13995	COG1234	tRNA 3'-trailer cleavage
HEP85_RS14000	COG0537	adenosine 5'-monophosphoramidase activity
HEP85_RS14025	COG0484	heat shock protein binding
HEP85_RS14030	COG1420	regulation of RNA biosynthetic process
HEP85_RS14080	COG0481	GTPase activity
HEP85_RS14085	COG0268	Binds directly to 16S ribosomal RNA
HEP85_RS14115	COG1555	photosystem II stabilization
HEP85_RS14115	COG1596	polysaccharide export
HEP85_RS14120	COG1307	EDD domain protein, DegV family
HEP85_RS14130	COG0495	leucyl-tRNA aminoacylation
HEP85_RS14140	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP85_RS14175	COG0588	phosphoglycerate mutase activity
HEP85_RS14180	COG0799	negative regulation of ribosome biogenesis
HEP85_RS14190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP85_RS14205	COG0501	Belongs to the peptidase M48B family
HEP85_RS14220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP85_RS14260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP85_RS14265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP85_RS14270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP85_RS14305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEP85_RS14335	COG0640	Transcriptional regulator
HEP85_RS14345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP85_RS14370	COG0596	Alpha beta hydrolase
HEP85_RS14410	COG0772	Belongs to the SEDS family
HEP85_RS14415	COG0768	penicillin binding
HEP85_RS14430	COG1077	Cell shape determining protein MreB Mrl
HEP85_RS14435	COG0105	UTP biosynthetic process
HEP85_RS14445	COG0285	dihydrofolate synthase activity
HEP85_RS14450	COG0525	valine-tRNA ligase activity
HEP85_RS14460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP85_RS14465	COG0740	serine-type endopeptidase activity
HEP85_RS14475	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP85_RS14500	COG3594	Acyltransferase
HEP85_RS14515	COG4552	Acetyltransferase involved in intracellular survival and related
HEP85_RS14530	COG1113	amino acid transport
HEP85_RS14535	COG0515	serine threonine protein kinase
HEP85_RS14550	COG1113	amino acid transport
HEP85_RS14555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEP85_RS14560	COG0588	phosphoglycerate mutase activity
HEP85_RS14570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEP85_RS14690	COG1595	DNA-templated transcription, initiation
HEP85_RS14720	COG0668	transmembrane transport
HEP85_RS14760	COG1175	transmembrane transport
HEP85_RS14770	COG1486	melibiose metabolic process
HEP85_RS14785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP85_RS14815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP85_RS14820	COG2346	COG2346, Truncated hemoglobins
HEP85_RS14840	COG1335	isochorismatase
HEP85_RS14860	COG1957	nucleoside hydrolase
HEP85_RS14885	COG2318	DinB family
HEP85_RS14980	COG0629	single-stranded DNA binding
HEP85_RS15010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP85_RS15025	COG2304	oxidoreductase activity
HEP85_RS15080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEP85_RS15185	COG3962	Belongs to the TPP enzyme family
HEP85_RS15190	COG3718	enzyme involved in inositol metabolism
HEP85_RS15200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP85_RS15245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP85_RS15255	COG1129	ABC transporter
HEP85_RS15265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP85_RS15270	COG1869	D-ribose catabolic process
HEP85_RS15290	COG0673	inositol 2-dehydrogenase activity
HEP85_RS15295	COG1609	Transcriptional regulator
HEP85_RS15305	COG1846	Transcriptional regulator
HEP85_RS15305	COG0456	acetyltransferase
HEP85_RS15315	COG0477	Major facilitator Superfamily
HEP85_RS15320	COG0181	hydroxymethylbilane synthase activity
HEP85_RS15335	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP85_RS15370	COG2356	endonuclease I
HEP85_RS15375	COG0028	Belongs to the TPP enzyme family
HEP85_RS15385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP85_RS15405	COG1946	Acyl-CoA thioesterase
HEP85_RS15415	COG1309	transcriptional regulator
HEP85_RS15420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP85_RS15435	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS15455	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HEP85_RS15490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP85_RS15500	COG0589	response to stress
HEP85_RS15515	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP85_RS15555	COG3979	chitinase
HEP85_RS15560	COG5002	protein histidine kinase activity
HEP85_RS15590	COG0406	alpha-ribazole phosphatase activity
HEP85_RS15645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS15660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP85_RS15675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP85_RS15680	COG0765	amino acid transport
HEP85_RS15685	COG0765	amino acid transport
HEP85_RS15690	COG1126	abc transporter atp-binding protein
HEP85_RS15705	COG1362	aminopeptidase activity
HEP85_RS15710	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS15720	COG3397	chitin binding
HEP85_RS15805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP85_RS15810	COG2188	Transcriptional regulator
HEP85_RS15825	COG0673	inositol 2-dehydrogenase activity
HEP85_RS15830	COG4702	Belongs to the UPF0303 family
HEP85_RS15840	COG0706	membrane insertase activity
HEP85_RS15850	COG3764	Sortase (surface protein transpeptidase)
HEP85_RS15965	COG2271	Major facilitator Superfamily
HEP85_RS15970	COG2733	membrane
HEP85_RS16000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP85_RS16040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP85_RS16050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP85_RS16055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEP85_RS16060	COG1263	PTS System
HEP85_RS16065	COG1263	PTS System
HEP85_RS16070	COG1234	tRNA 3'-trailer cleavage
HEP85_RS16095	COG1113	amino acid transport
HEP85_RS16105	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HEP85_RS16115	COG1335	isochorismatase
HEP85_RS16150	COG0277	FAD linked oxidase domain protein
HEP85_RS16160	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HEP85_RS16170	COG1174	glycine betaine transport
HEP85_RS16175	COG1125	glycine betaine transport
HEP85_RS16175	COG0517	IMP dehydrogenase activity
HEP85_RS16180	COG1174	glycine betaine transport
HEP85_RS16200	COG3480	Lon protease (S16) C-terminal proteolytic domain
HEP85_RS16215	COG3654	unkown
HEP85_RS16265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP85_RS16270	COG0395	ABC-type sugar transport system, permease component
HEP85_RS16275	COG1175	transmembrane transport
HEP85_RS16290	COG1678	Uncharacterized ACR, COG1678
HEP85_RS16295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEP85_RS16300	COG0776	regulation of translation
HEP85_RS16310	COG3973	AAA domain
HEP85_RS16340	COG2223	nitrite transmembrane transporter activity
HEP85_RS16365	COG0583	DNA-binding transcription factor activity
HEP85_RS16380	COG1175	transmembrane transport
HEP85_RS16385	COG0395	ABC-type sugar transport system, permease component
HEP85_RS16390	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP85_RS16415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP85_RS16420	COG0793	Belongs to the peptidase S41A family
HEP85_RS16430	COG2884	Cell division ATP-binding protein ftsE
HEP85_RS16445	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP85_RS16455	COG0515	serine threonine protein kinase
HEP85_RS16470	COG1175	transmembrane transport
HEP85_RS16475	COG0395	ABC-type sugar transport system, permease component
HEP85_RS16480	COG0463	Glycosyl transferase, family 2
HEP85_RS16480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP85_RS16485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP85_RS16500	COG1764	response to oxidative stress
HEP85_RS16505	COG1846	Transcriptional regulator
HEP85_RS16545	COG1309	transcriptional regulator
HEP85_RS16555	COG1134	teichoic acid transport
HEP85_RS16560	COG0438	transferase activity, transferring glycosyl groups
HEP85_RS16575	COG2902	Dehydrogenase
HEP85_RS16600	COG0653	protein targeting
HEP85_RS16610	COG3214	Protein conserved in bacteria
HEP85_RS16615	COG2197	response regulator
HEP85_RS16620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEP85_RS16630	COG0823	Involved in the tonB-independent uptake of proteins
HEP85_RS16640	COG0745	RESPONSE REGULATOR receiver
HEP85_RS16645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEP85_RS16665	COG0714	Associated with various cellular activities
HEP85_RS16705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HEP85_RS16715	COG1482	cell wall glycoprotein biosynthetic process
HEP85_RS16725	COG2835	tetraacyldisaccharide 4'-kinase activity
HEP85_RS16730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP85_RS16735	COG1620	l-lactate permease
HEP85_RS16770	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEP85_RS16775	COG0778	Nitroreductase
HEP85_RS16775	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HEP85_RS16800	COG1316	TRANSCRIPTIONal
HEP85_RS16805	COG1316	TRANSCRIPTIONal
HEP85_RS16815	COG1316	TRANSCRIPTIONal
HEP85_RS16820	COG1316	TRANSCRIPTIONal
HEP85_RS16830	COG1011	Hydrolase
HEP85_RS16850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEP85_RS16905	COG2205	protein histidine kinase activity
HEP85_RS16910	COG0745	RESPONSE REGULATOR receiver
HEP85_RS16915	COG3104	oligopeptide transport
HEP85_RS16945	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP85_RS16950	COG1191	sigma factor activity
HEP85_RS16960	COG1228	amidohydrolase
HEP85_RS16970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP85_RS16975	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP85_RS17015	COG2986	histidine ammonia-lyase
HEP85_RS17025	COG1174	glycine betaine transport
HEP85_RS17030	COG1174	glycine betaine transport
HEP85_RS17040	COG1609	Transcriptional regulator
HEP85_RS17070	COG0183	Belongs to the thiolase family
HEP85_RS17105	COG1136	(ABC) transporter
HEP85_RS17110	COG0577	efflux transmembrane transporter activity
HEP85_RS17115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP85_RS17140	COG0148	phosphopyruvate hydratase activity
HEP85_RS17155	COG2124	cytochrome p450
HEP85_RS17230	COG0577	efflux transmembrane transporter activity
HEP85_RS17230	COG1136	(ABC) transporter
HEP85_RS17235	COG1136	(ABC) transporter
HEP85_RS17240	COG0477	Major facilitator Superfamily
HEP85_RS17250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP85_RS17280	COG4585	Histidine kinase
HEP85_RS17295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP85_RS17300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HEP85_RS17305	COG0193	aminoacyl-tRNA hydrolase activity
HEP85_RS17315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HEP85_RS17325	COG1309	transcriptional regulator
HEP85_RS17345	COG4106	trans-aconitate 2-methyltransferase activity
HEP85_RS17350	COG1846	Transcriptional regulator
HEP85_RS17365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HEP85_RS17410	COG0488	(ABC) transporter
HEP85_RS17425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEP85_RS17435	COG0084	hydrolase, TatD family'
HEP85_RS17475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEP85_RS17480	COG2188	Transcriptional regulator
HEP85_RS17600	COG1764	response to oxidative stress
HEP85_RS17605	COG1122	ATPase activity
HEP85_RS17615	COG0310	cobalt ion transport
HEP85_RS17635	COG0793	Belongs to the peptidase S41A family
HEP85_RS17635	COG4946	Tricorn protease homolog
HEP85_RS17645	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS17650	COG2267	carboxylic ester hydrolase activity
HEP85_RS17655	COG2072	flavoprotein involved in K transport
HEP85_RS17665	COG0708	Exodeoxyribonuclease III
HEP85_RS17685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP85_RS17690	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP85_RS17690	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP85_RS17695	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP85_RS17705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP85_RS17710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP85_RS17725	COG0477	Major facilitator Superfamily
HEP85_RS17735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP85_RS17745	COG1970	mechanosensitive ion channel activity
HEP85_RS17780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP85_RS17780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP85_RS17780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP85_RS17790	COG1349	DNA-binding transcription factor activity
HEP85_RS17795	COG0477	Major facilitator Superfamily
HEP85_RS17810	COG1247	-acetyltransferase
HEP85_RS17820	COG1846	Transcriptional regulator
HEP85_RS17850	COG0477	Major facilitator Superfamily
HEP85_RS17890	COG2188	Transcriptional regulator
HEP85_RS17905	COG2226	methyltransferase
HEP85_RS17960	COG0386	Belongs to the glutathione peroxidase family
HEP85_RS17975	COG1686	Belongs to the peptidase S11 family
HEP85_RS18030	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP85_RS18045	COG4221	oxidoreductase activity
HEP85_RS18050	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS18115	COG1024	Enoyl-CoA hydratase
HEP85_RS18135	COG1309	transcriptional regulator
HEP85_RS18170	COG0259	pyridoxamine-phosphate oxidase activity
HEP85_RS18195	COG2072	flavoprotein involved in K transport
HEP85_RS18205	COG1024	Enoyl-CoA hydratase
HEP85_RS18235	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS18240	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS18255	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS18260	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS18270	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS18285	COG1595	DNA-templated transcription, initiation
HEP85_RS18335	COG2945	thiolester hydrolase activity
HEP85_RS18335	COG0596	Alpha beta hydrolase
HEP85_RS18345	COG4821	SIS domain
HEP85_RS18365	COG0259	pyridoxamine-phosphate oxidase activity
HEP85_RS18380	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS18420	COG0277	FAD linked oxidase domain protein
HEP85_RS18420	COG0247	lactate metabolic process
HEP85_RS18455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP85_RS18470	COG0667	Aldo Keto reductase
HEP85_RS18485	COG1846	Transcriptional regulator
HEP85_RS18495	COG2252	PERMEase
HEP85_RS18505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEP85_RS18530	COG2814	Major facilitator Superfamily
HEP85_RS18540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEP85_RS18545	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP85_RS18550	COG1278	Cold shock
HEP85_RS18575	COG1061	Type III restriction enzyme res subunit
HEP85_RS18595	COG3973	AAA domain
HEP85_RS18630	COG1737	Transcriptional regulator
HEP85_RS18635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HEP85_RS18655	COG0459	protein refolding
HEP85_RS18675	COG0463	Glycosyl transferase, family 2
HEP85_RS18695	COG2182	Extracellular solute-binding protein
HEP85_RS18795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP85_RS18795	COG0723	plastoquinol--plastocyanin reductase activity
HEP85_RS18865	COG3842	ATPase activity
HEP85_RS18890	COG0215	cysteine-tRNA ligase activity
HEP85_RS18895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP85_RS18900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP85_RS18905	COG1329	Transcriptional regulator
HEP85_RS18925	COG5002	protein histidine kinase activity
HEP85_RS18950	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS19025	COG4974	Belongs to the 'phage' integrase family
HEP85_RS19030	COG0222	ribosome binding
HEP85_RS19035	COG0588	phosphoglycerate mutase activity
HEP85_RS19065	COG0438	transferase activity, transferring glycosyl groups
HEP85_RS19135	COG0546	phosphoglycolate phosphatase activity
HEP85_RS19140	COG2188	Transcriptional regulator
HEP85_RS19150	COG2188	Transcriptional regulator
HEP85_RS19160	COG4552	Acetyltransferase involved in intracellular survival and related
HEP85_RS19175	COG1490	D-aminoacyl-tRNA deacylase activity
HEP85_RS19180	COG0354	folic acid binding
HEP85_RS19190	COG0745	RESPONSE REGULATOR receiver
HEP85_RS19195	COG3485	protocatechuate 3,4-dioxygenase
HEP85_RS19230	COG2897	thiosulfate sulfurtransferase activity
HEP85_RS19255	COG0745	RESPONSE REGULATOR receiver
HEP85_RS19260	COG1609	Transcriptional regulator
HEP85_RS19270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP85_RS19295	COG1132	(ABC) transporter
HEP85_RS19315	COG0737	Belongs to the 5'-nucleotidase family
HEP85_RS19320	COG0456	acetyltransferase
HEP85_RS19335	COG1131	(ABC) transporter
HEP85_RS19355	COG1725	Transcriptional regulator
HEP85_RS19360	COG1131	(ABC) transporter
HEP85_RS19405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEP85_RS19410	COG0306	phosphate transporter
HEP85_RS19420	COG1937	Protein conserved in bacteria
HEP85_RS19440	COG0277	FAD linked oxidase domain protein
HEP85_RS19445	COG0671	phosphoesterase, PA-phosphatase related
HEP85_RS19450	COG0739	heme binding
HEP85_RS19450	COG1196	nuclear chromosome segregation
HEP85_RS19450	COG0741	lytic transglycosylase activity
HEP85_RS19535	COG1252	NADH dehydrogenase
HEP85_RS19570	COG0579	oxidoreductase
HEP85_RS19575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HEP85_RS19585	COG0667	Aldo Keto reductase
HEP85_RS19615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP85_RS19665	COG1643	Atp-dependent helicase
HEP85_RS19700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HEP85_RS19720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP85_RS19725	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP85_RS19730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP85_RS19765	COG2197	response regulator
HEP85_RS19790	COG0151	Belongs to the GarS family
HEP85_RS19810	COG3629	intracellular signal transduction
HEP85_RS19810	COG3903	Transcriptional regulator
HEP85_RS19840	COG0270	DNA (cytosine-5-)-methyltransferase activity
HEP85_RS19955	COG0300	oxidoreductase activity
HEP85_RS19970	COG0156	8-amino-7-oxononanoate synthase activity
HEP85_RS20025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP85_RS20135	COG1191	sigma factor activity
HEP85_RS20140	COG1191	sigma factor activity
HEP85_RS20160	COG0477	Major facilitator Superfamily
HEP85_RS20165	COG2353	YceI-like domain
HEP85_RS20170	COG3467	pyridoxamine 5'-phosphate
HEP85_RS20180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP85_RS20190	COG2205	protein histidine kinase activity
HEP85_RS20195	COG0745	RESPONSE REGULATOR receiver
HEP85_RS20270	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS20275	COG1595	DNA-templated transcription, initiation
HEP85_RS20300	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS20340	COG0346	lactoylglutathione lyase activity
HEP85_RS20380	COG0006	proline dipeptidase activity
HEP85_RS20425	COG2837	iron assimilation
HEP85_RS20435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEP85_RS20440	COG0561	phosphatase activity
HEP85_RS20470	COG1131	(ABC) transporter
HEP85_RS20490	COG0789	Transcriptional regulator
HEP85_RS20495	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP85_RS20580	COG2091	lysine biosynthetic process via aminoadipic acid
HEP85_RS20610	COG0561	phosphatase activity
HEP85_RS20625	COG1294	oxidase, subunit
HEP85_RS20630	COG1271	oxidase subunit
HEP85_RS20635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP85_RS20640	COG1609	Transcriptional regulator
HEP85_RS20660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HEP85_RS20685	COG0662	Cupin 2, conserved barrel domain protein
HEP85_RS20690	COG1950	PFAM Membrane protein of
HEP85_RS20695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP85_RS20700	COG0626	cystathionine gamma-synthase activity
HEP85_RS20735	COG2814	Major facilitator Superfamily
HEP85_RS20755	COG0305	Participates in initiation and elongation during chromosome replication
HEP85_RS20765	COG0359	binds to the 23S rRNA
HEP85_RS20770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEP85_RS20775	COG0629	single-stranded DNA binding
HEP85_RS20780	COG0360	Binds together with S18 to 16S ribosomal RNA
HEP85_RS20815	COG1260	myo-inositol-1-phosphate synthase
HEP85_RS20830	COG0617	tRNA 3'-terminal CCA addition
HEP85_RS20850	COG1595	DNA-templated transcription, initiation
HEP85_RS20860	COG0492	ferredoxin-NADP+ reductase activity
HEP85_RS20865	COG3118	belongs to the thioredoxin family
HEP85_RS20880	COG1192	Involved in chromosome partitioning
HEP85_RS20885	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP85_RS20895	COG0706	membrane insertase activity
HEP85_RS20900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HEP85_RS20905	COG0594	ribonuclease P activity
HEP85_RS20910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HEP85_RS20915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HEP85_RS20920	COG0592	DNA-directed DNA polymerase activity
HEP85_RS20925	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP85_RS20930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP85_RS20935	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HEP85_RS20940	COG0187	DNA topoisomerase II activity
HEP85_RS20945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEP85_RS20980	COG0515	serine threonine protein kinase
HEP85_RS21005	COG0705	Rhomboid family
HEP85_RS21020	COG3764	Sortase (surface protein transpeptidase)
HEP85_RS21040	COG3764	Sortase (surface protein transpeptidase)
HEP85_RS21045	COG0515	serine threonine protein kinase
HEP85_RS21065	COG1716	ATPase activity
HEP85_RS21100	COG0745	RESPONSE REGULATOR receiver
HEP85_RS21115	COG4770	biotin carboxylase activity
HEP85_RS21130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP85_RS21175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP85_RS21205	COG0475	glutathione-regulated potassium exporter activity
HEP85_RS21215	COG1733	regulation of RNA biosynthetic process
HEP85_RS21220	COG0477	Major facilitator Superfamily
HEP85_RS21240	COG0277	FAD linked oxidase domain protein
HEP85_RS21260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HEP85_RS21265	COG1733	regulation of RNA biosynthetic process
HEP85_RS21290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP85_RS21295	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP85_RS21300	COG3396	Phenylacetate-CoA oxygenase
HEP85_RS21305	COG3460	Phenylacetate-CoA oxygenase
HEP85_RS21310	COG3396	Phenylacetate-CoA oxygenase
HEP85_RS21335	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP85_RS21340	COG1309	transcriptional regulator
HEP85_RS21345	COG1522	sequence-specific DNA binding
HEP85_RS21390	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS21390	COG0604	alcohol dehydrogenase
HEP85_RS21390	COG3321	synthase
HEP85_RS21410	COG0515	serine threonine protein kinase
HEP85_RS21435	COG0022	dehydrogenase e1 component
HEP85_RS21440	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP85_RS21530	COG1362	aminopeptidase activity
HEP85_RS21535	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS21545	COG1741	Belongs to the pirin family
HEP85_RS21560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HEP85_RS21580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP85_RS21590	COG0583	DNA-binding transcription factor activity
HEP85_RS21595	COG5640	endopeptidase activity
HEP85_RS21600	COG1289	transmembrane transporter activity
HEP85_RS21655	COG1473	amidohydrolase
HEP85_RS21670	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HEP85_RS21680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP85_RS21705	COG2267	carboxylic ester hydrolase activity
HEP85_RS21715	COG0222	ribosome binding
HEP85_RS21730	COG1278	Cold shock
HEP85_RS21760	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEP85_RS21810	COG1595	DNA-templated transcription, initiation
HEP85_RS21855	COG0515	serine threonine protein kinase
HEP85_RS21855	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP85_RS21890	COG0717	Belongs to the dCTP deaminase family
HEP85_RS21925	COG2181	nitrate reductase activity
HEP85_RS21925	COG0247	lactate metabolic process
HEP85_RS21935	COG0443	Heat shock 70 kDa protein
HEP85_RS21940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP85_RS21945	COG0484	heat shock protein binding
HEP85_RS21950	COG0789	Transcriptional regulator
HEP85_RS21955	COG4213	ABC transporter substrate-binding protein
HEP85_RS21990	COG0542	response to heat
HEP85_RS22020	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HEP85_RS22035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP85_RS22040	COG0191	fructose-bisphosphate aldolase activity
HEP85_RS22045	COG0477	Major facilitator Superfamily
HEP85_RS22060	COG3844	kynureninase activity
HEP85_RS22085	COG4585	Histidine kinase
HEP85_RS22090	COG2197	response regulator
HEP85_RS22095	COG4585	Histidine kinase
HEP85_RS22100	COG2197	response regulator
HEP85_RS22110	COG3559	Exporter of polyketide antibiotics
HEP85_RS22115	COG1131	(ABC) transporter
HEP85_RS22130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP85_RS22150	COG0737	Belongs to the 5'-nucleotidase family
HEP85_RS22170	COG0463	Glycosyl transferase, family 2
HEP85_RS22175	COG1802	Transcriptional regulator
HEP85_RS22205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEP85_RS22210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HEP85_RS22230	COG1595	DNA-templated transcription, initiation
HEP85_RS22320	COG1609	Transcriptional regulator
HEP85_RS22335	COG1408	metallophosphoesterase
HEP85_RS22345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP85_RS22360	COG0003	Pfam Anion-transporting ATPase
HEP85_RS22385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP85_RS22420	COG0596	Alpha beta hydrolase
HEP85_RS22430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEP85_RS22435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP85_RS22440	COG0659	secondary active sulfate transmembrane transporter activity
HEP85_RS22500	COG1111	helicase
HEP85_RS22500	COG1205	dead DEAH box helicase
HEP85_RS22505	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP85_RS22510	COG2172	sigma factor antagonist activity
HEP85_RS22515	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP85_RS22535	COG1754	DNA topoisomerase type I activity
HEP85_RS22535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP85_RS22545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEP85_RS22595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP85_RS22595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP85_RS22635	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS22645	COG0076	glutamate decarboxylase activity
HEP85_RS22655	COG0789	Transcriptional regulator
HEP85_RS22670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP85_RS22685	COG0037	tRNA processing
HEP85_RS22700	COG0302	gtp cyclohydrolase
HEP85_RS22715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP85_RS22755	COG0649	NAD binding
HEP85_RS22770	COG2197	response regulator
HEP85_RS22790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HEP85_RS22795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEP85_RS22805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HEP85_RS22825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HEP85_RS22850	COG0739	heme binding
HEP85_RS22865	COG2205	protein histidine kinase activity
HEP85_RS22870	COG0745	RESPONSE REGULATOR receiver
HEP85_RS22880	COG1595	DNA-templated transcription, initiation
HEP85_RS22895	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HEP85_RS22915	COG0248	Ppx GppA phosphatase
HEP85_RS22920	COG1082	Xylose isomerase domain protein TIM barrel
HEP85_RS22925	COG1309	transcriptional regulator
HEP85_RS22930	COG0129	dihydroxy-acid dehydratase activity
HEP85_RS22945	COG4991	sh3 domain protein
HEP85_RS22965	COG1129	ABC transporter
HEP85_RS22965	COG0842	Transport permease protein
HEP85_RS22975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEP85_RS22980	COG0180	Tryptophanyl-tRNA synthetase
HEP85_RS23015	COG0123	including yeast histone deacetylase and acetoin utilization protein
HEP85_RS23065	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HEP85_RS23070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEP85_RS23075	COG0181	hydroxymethylbilane synthase activity
HEP85_RS23080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP85_RS23080	COG1648	precorrin-2 dehydrogenase activity
HEP85_RS23085	COG0113	porphobilinogen synthase activity
HEP85_RS23120	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HEP85_RS23140	COG1690	Belongs to the RtcB family
HEP85_RS23170	COG0431	NADPH-dependent FMN reductase
HEP85_RS23180	COG2205	protein histidine kinase activity
HEP85_RS23195	COG0531	amino acid
HEP85_RS23215	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP85_RS23220	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP85_RS23225	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEP85_RS23235	COG0531	amino acid
HEP85_RS23240	COG0598	Magnesium transport protein CorA
HEP85_RS23250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP85_RS23255	COG0406	alpha-ribazole phosphatase activity
HEP85_RS23270	COG0785	Cytochrome C biogenesis protein
HEP85_RS23275	COG1333	cytochrome c biogenesis protein
HEP85_RS23280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEP85_RS23315	COG2226	methyltransferase
HEP85_RS23325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEP85_RS23335	COG0163	prenyltransferase activity
HEP85_RS23355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP85_RS23375	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP85_RS23390	COG1309	transcriptional regulator
HEP85_RS23410	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP85_RS23425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP85_RS23440	COG2226	methyltransferase
HEP85_RS23470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP85_RS23475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP85_RS23480	COG0649	NAD binding
HEP85_RS23490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP85_RS23495	COG1034	ATP synthesis coupled electron transport
HEP85_RS23500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEP85_RS23505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP85_RS23515	COG0713	ATP synthesis coupled electron transport
HEP85_RS23520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP85_RS23530	COG1007	ATP synthesis coupled electron transport
HEP85_RS23540	COG0514	ATP-dependent DNA helicase (RecQ)
HEP85_RS23555	COG0492	ferredoxin-NADP+ reductase activity
HEP85_RS23560	COG0561	phosphatase activity
HEP85_RS23580	COG1131	(ABC) transporter
HEP85_RS23615	COG0702	epimerase
HEP85_RS23620	COG1733	regulation of RNA biosynthetic process
HEP85_RS23625	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEP85_RS23630	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEP85_RS23630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEP85_RS23650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP85_RS23655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP85_RS23665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEP85_RS23670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP85_RS23675	COG0839	Belongs to the complex I subunit 6 family
HEP85_RS23680	COG0713	ATP synthesis coupled electron transport
HEP85_RS23685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP85_RS23695	COG1007	ATP synthesis coupled electron transport
HEP85_RS23700	COG0501	Belongs to the peptidase M48B family
HEP85_RS23720	COG2261	transglycosylase associated protein
HEP85_RS23725	COG1666	GTP binding
HEP85_RS23740	COG0702	epimerase
HEP85_RS23760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP85_RS23765	COG2030	dehydratase
HEP85_RS23785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP85_RS23790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP85_RS23795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP85_RS23800	COG0436	Aminotransferase
HEP85_RS23820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP85_RS23825	COG0081	regulation of translation
HEP85_RS23840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HEP85_RS23845	COG0222	ribosome binding
HEP85_RS23850	COG0085	RNA polymerase activity
HEP85_RS23855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP85_RS23890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP85_RS23895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HEP85_RS23900	COG0049	tRNA binding
HEP85_RS23905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP85_RS23910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP85_RS23915	COG2124	cytochrome p450
HEP85_RS23930	COG1404	Belongs to the peptidase S8 family
HEP85_RS23950	COG0051	transcription antitermination factor activity, RNA binding
HEP85_RS23955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HEP85_RS23960	COG0088	Forms part of the polypeptide exit tunnel
HEP85_RS23965	COG0089	rRNA binding
HEP85_RS23970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP85_RS23975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEP85_RS23980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HEP85_RS23985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HEP85_RS23990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEP85_RS23995	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP85_RS24000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP85_RS24005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HEP85_RS24010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP85_RS24015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP85_RS24020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEP85_RS24030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HEP85_RS24035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HEP85_RS24040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HEP85_RS24045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEP85_RS24050	COG1841	ribosomal large subunit assembly
HEP85_RS24055	COG0200	Binds to the 23S rRNA
HEP85_RS24065	COG0563	adenylate kinase activity
HEP85_RS24075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEP85_RS24080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HEP85_RS24085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEP85_RS24090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEP85_RS24095	COG0202	RNA polymerase activity
HEP85_RS24100	COG0203	ribosomal protein L17
HEP85_RS24105	COG0101	tRNA pseudouridine synthase activity
HEP85_RS24115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HEP85_RS24120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HEP85_RS24125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP85_RS24135	COG1072	(Pantothenic acid kinase))
HEP85_RS24140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP85_RS24145	COG0736	holo-[acyl-carrier-protein] synthase activity
HEP85_RS24170	COG0802	atpase or kinase
HEP85_RS24195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEP85_RS24215	COG1175	transmembrane transport
HEP85_RS24220	COG1653	transport
HEP85_RS24225	COG1609	Transcriptional regulator
HEP85_RS24230	COG1316	TRANSCRIPTIONal
HEP85_RS24245	COG4941	Belongs to the sigma-70 factor family
HEP85_RS24260	COG0726	polysaccharide deacetylase
HEP85_RS24265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HEP85_RS24270	COG0459	protein refolding
HEP85_RS24275	COG4221	oxidoreductase activity
HEP85_RS24285	COG0583	DNA-binding transcription factor activity
HEP85_RS24300	COG1595	DNA-templated transcription, initiation
HEP85_RS24310	COG0516	GMP reductase activity
HEP85_RS24320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEP85_RS24340	COG0515	serine threonine protein kinase
HEP85_RS24345	COG0515	serine threonine protein kinase
HEP85_RS24350	COG0515	serine threonine protein kinase
HEP85_RS24355	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS24380	COG0519	Catalyzes the synthesis of GMP from XMP
HEP85_RS24380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP85_RS24425	COG2197	response regulator
HEP85_RS24435	COG0791	NLP P60 protein
HEP85_RS24460	COG0739	heme binding
HEP85_RS24465	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HEP85_RS24470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS24470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS24485	COG0714	Associated with various cellular activities
HEP85_RS24495	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP85_RS24505	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP85_RS24535	COG0138	bifunctional purine biosynthesis protein purh
HEP85_RS24565	COG0039	L-malate dehydrogenase activity
HEP85_RS24590	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS24600	COG0517	IMP dehydrogenase activity
HEP85_RS24600	COG4175	Glycine betaine
HEP85_RS24615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP85_RS24635	COG0754	glutathionylspermidine amidase activity
HEP85_RS24640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP85_RS24645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP85_RS24665	COG0180	Tryptophanyl-tRNA synthetase
HEP85_RS24695	COG1295	ribonuclease BN
HEP85_RS24710	COG1408	metallophosphoesterase
HEP85_RS24720	COG2205	protein histidine kinase activity
HEP85_RS24725	COG0745	RESPONSE REGULATOR receiver
HEP85_RS24730	COG2409	Drug exporters of the RND superfamily
HEP85_RS24740	COG1309	transcriptional regulator
HEP85_RS24775	COG1053	succinate dehydrogenase
HEP85_RS24785	COG2009	succinate dehydrogenase
HEP85_RS24795	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP85_RS24825	COG1595	DNA-templated transcription, initiation
HEP85_RS24845	COG1595	DNA-templated transcription, initiation
HEP85_RS24860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS24860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS24890	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP85_RS24900	COG1216	Glycosyl transferase, family 2
HEP85_RS24915	COG2089	acid synthase
HEP85_RS24970	COG1473	amidohydrolase
HEP85_RS24970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEP85_RS24975	COG1744	ABC transporter substrate-binding protein PnrA-like
HEP85_RS24985	COG1744	ABC transporter substrate-binding protein PnrA-like
HEP85_RS25030	COG2814	Major facilitator Superfamily
HEP85_RS25035	COG0583	DNA-binding transcription factor activity
HEP85_RS25045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP85_RS25070	COG2205	protein histidine kinase activity
HEP85_RS25075	COG0745	RESPONSE REGULATOR receiver
HEP85_RS25080	COG1595	DNA-templated transcription, initiation
HEP85_RS25095	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS25100	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS25105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HEP85_RS25120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP85_RS25145	COG4770	biotin carboxylase activity
HEP85_RS25155	COG0424	maF-like protein
HEP85_RS25170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP85_RS25180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP85_RS25185	COG1024	Enoyl-CoA hydratase
HEP85_RS25195	COG2986	histidine ammonia-lyase
HEP85_RS25200	COG1278	Cold shock
HEP85_RS25235	COG1136	(ABC) transporter
HEP85_RS25240	COG1404	Belongs to the peptidase S8 family
HEP85_RS25255	COG1064	alcohol dehydrogenase
HEP85_RS25280	COG1785	Belongs to the alkaline phosphatase family
HEP85_RS25355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP85_RS25375	COG2255	four-way junction helicase activity
HEP85_RS25380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP85_RS25395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP85_RS25405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP85_RS25425	COG1331	Highly conserved protein containing a thioredoxin domain
HEP85_RS25455	COG1309	transcriptional regulator
HEP85_RS25460	COG0477	Major facilitator Superfamily
HEP85_RS25470	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HEP85_RS25495	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS25510	COG0436	Aminotransferase
HEP85_RS25520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HEP85_RS25535	COG1414	Transcriptional regulator
HEP85_RS25540	COG0251	oxidation-reduction process
HEP85_RS25545	COG2610	gluconate transmembrane transporter activity
HEP85_RS25610	COG2894	cell division
HEP85_RS25640	COG2197	response regulator
HEP85_RS25660	COG2885	chlorophyll binding
HEP85_RS25665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEP85_RS25695	COG2318	DinB family
HEP85_RS25710	COG0667	Aldo Keto reductase
HEP85_RS25715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP85_RS25720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP85_RS25725	COG0741	lytic transglycosylase activity
HEP85_RS25735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP85_RS25740	COG0450	alkyl hydroperoxide reductase
HEP85_RS25755	COG1136	(ABC) transporter
HEP85_RS25775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEP85_RS25795	COG0114	fumarate hydratase activity
HEP85_RS25815	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEP85_RS25815	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEP85_RS25840	COG0778	Nitroreductase
HEP85_RS25845	COG1722	exodeoxyribonuclease VII activity
HEP85_RS25850	COG1570	exodeoxyribonuclease VII activity
HEP85_RS25855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP85_RS25870	COG0012	GTP binding
HEP85_RS25875	COG2161	toxin-antitoxin pair type II binding
HEP85_RS25880	COG4115	mRNA cleavage
HEP85_RS25885	COG0133	tryptophan synthase activity
HEP85_RS25940	COG1053	succinate dehydrogenase
HEP85_RS25980	COG0444	Belongs to the ABC transporter superfamily
HEP85_RS25985	COG4608	Belongs to the ABC transporter superfamily
HEP85_RS26000	COG2318	DinB family
HEP85_RS26030	COG0444	Belongs to the ABC transporter superfamily
HEP85_RS26035	COG0601	transmembrane transport
HEP85_RS26040	COG0747	negative chemotaxis
HEP85_RS26055	COG0601	transmembrane transport
HEP85_RS26060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP85_RS26065	COG0444	Belongs to the ABC transporter superfamily
HEP85_RS26070	COG4608	Belongs to the ABC transporter superfamily
HEP85_RS26090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP85_RS26110	COG1131	(ABC) transporter
HEP85_RS26120	COG4585	Histidine kinase
HEP85_RS26125	COG2197	response regulator
HEP85_RS26160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP85_RS26180	COG2818	Glycosylase
HEP85_RS26185	COG1024	Enoyl-CoA hydratase
HEP85_RS26200	COG1595	DNA-templated transcription, initiation
HEP85_RS26210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP85_RS26215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP85_RS26240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP85_RS26250	COG0598	Magnesium transport protein CorA
HEP85_RS26260	COG2814	Major facilitator Superfamily
HEP85_RS26275	COG2095	MarC family integral membrane protein
HEP85_RS26285	COG1432	Conserved Protein
HEP85_RS26335	COG0747	negative chemotaxis
HEP85_RS26405	COG0210	DNA helicase
HEP85_RS26410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP85_RS26450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP85_RS26505	COG3480	Lon protease (S16) C-terminal proteolytic domain
HEP85_RS26515	COG1615	UPF0182 protein
HEP85_RS26540	COG0753	catalase activity
HEP85_RS26550	COG0483	inositol monophosphate 1-phosphatase activity
HEP85_RS26560	COG2076	Multidrug Resistance protein
HEP85_RS26570	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HEP85_RS26580	COG2135	peptidase activity
HEP85_RS26590	COG1595	DNA-templated transcription, initiation
HEP85_RS26595	COG5662	AntiSigma factor
HEP85_RS26615	COG0242	peptide deformylase activity
HEP85_RS26625	COG2124	cytochrome p450
HEP85_RS26650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP85_RS26675	COG2188	Transcriptional regulator
HEP85_RS26680	COG2182	Extracellular solute-binding protein
HEP85_RS26685	COG1175	transmembrane transport
HEP85_RS26690	COG0395	ABC-type sugar transport system, permease component
HEP85_RS26695	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP85_RS26700	COG0363	glucosamine-6-phosphate deaminase activity
HEP85_RS26715	COG1597	lipid kinase activity
HEP85_RS26745	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HEP85_RS26760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP85_RS26770	COG0456	acetyltransferase
HEP85_RS26855	COG4106	trans-aconitate 2-methyltransferase activity
HEP85_RS26860	COG1126	abc transporter atp-binding protein
HEP85_RS26865	COG0765	amino acid transport
HEP85_RS26875	COG0281	malic enzyme
HEP85_RS26880	COG0604	alcohol dehydrogenase
HEP85_RS26920	COG2205	protein histidine kinase activity
HEP85_RS26925	COG0745	RESPONSE REGULATOR receiver
HEP85_RS26940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEP85_RS26980	COG2132	Multicopper oxidase
HEP85_RS27020	COG0768	penicillin binding
HEP85_RS27025	COG0772	Belongs to the SEDS family
HEP85_RS27050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP85_RS27060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEP85_RS27065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP85_RS27070	COG0583	DNA-binding transcription factor activity
HEP85_RS27085	COG1063	alcohol dehydrogenase
HEP85_RS27125	COG0477	Major facilitator Superfamily
HEP85_RS27170	COG0326	Molecular chaperone. Has ATPase activity
HEP85_RS27200	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HEP85_RS27205	COG2188	Transcriptional regulator
HEP85_RS27250	COG1674	ftsk spoiiie
HEP85_RS27270	COG0270	DNA (cytosine-5-)-methyltransferase activity
HEP85_RS27310	COG0018	arginyl-trna synthetase
HEP85_RS27315	COG0019	diaminopimelate decarboxylase activity
HEP85_RS27320	COG0460	homoserine dehydrogenase
HEP85_RS27325	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP85_RS27330	COG0083	homoserine kinase activity
HEP85_RS27350	COG0254	rRNA binding
HEP85_RS27355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP85_RS27360	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP85_RS27370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP85_RS27375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP85_RS27380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP85_RS27395	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEP85_RS27400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP85_RS27405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEP85_RS27410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP85_RS27415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HEP85_RS27420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEP85_RS27425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP85_RS27445	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP85_RS27460	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HEP85_RS27505	COG1131	(ABC) transporter
HEP85_RS27525	COG0183	Belongs to the thiolase family
HEP85_RS27540	COG0745	RESPONSE REGULATOR receiver
HEP85_RS27545	COG2205	protein histidine kinase activity
HEP85_RS27590	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS27590	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS27625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEP85_RS27630	COG0857	belongs to the CobB CobQ family
HEP85_RS27630	COG0280	phosphate acetyltransferase
HEP85_RS27635	COG0205	6-phosphofructokinase activity
HEP85_RS27645	COG0395	ABC-type sugar transport system, permease component
HEP85_RS27650	COG1175	transmembrane transport
HEP85_RS27660	COG4565	transcriptional regulatory protein
HEP85_RS27665	COG3290	protein histidine kinase activity
HEP85_RS27670	COG1301	dicarboxylic acid transport
HEP85_RS27695	COG3118	belongs to the thioredoxin family
HEP85_RS27695	COG0492	ferredoxin-NADP+ reductase activity
HEP85_RS27730	COG0058	SHG alpha-glucan phosphorylase activity
HEP85_RS27750	COG0604	alcohol dehydrogenase
HEP85_RS27765	COG1132	(ABC) transporter
HEP85_RS27770	COG1132	(ABC) transporter
HEP85_RS27775	COG1132	(ABC) transporter
HEP85_RS27790	COG4585	Histidine kinase
HEP85_RS27795	COG2197	response regulator
HEP85_RS27805	COG1376	ErfK ybiS ycfS ynhG family protein
HEP85_RS27810	COG1376	ErfK ybiS ycfS ynhG family protein
HEP85_RS27845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP85_RS27880	COG1760	l-serine dehydratase
HEP85_RS27885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP85_RS27890	COG0509	glycine decarboxylation via glycine cleavage system
HEP85_RS27895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP85_RS27920	COG0747	negative chemotaxis
HEP85_RS27925	COG0601	transmembrane transport
HEP85_RS27930	COG0444	Belongs to the ABC transporter superfamily
HEP85_RS27935	COG4608	Belongs to the ABC transporter superfamily
HEP85_RS27945	COG2860	membrane
HEP85_RS27985	COG0482	sulfurtransferase activity
HEP85_RS27995	COG1611	Belongs to the LOG family
HEP85_RS28000	COG4221	oxidoreductase activity
HEP85_RS28010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP85_RS28020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEP85_RS28025	COG0154	amidase activity
HEP85_RS28035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEP85_RS28040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP85_RS28055	COG2197	response regulator
HEP85_RS28065	COG2133	pyrroloquinoline quinone binding
HEP85_RS28070	COG0667	Aldo Keto reductase
HEP85_RS28095	COG0440	acetolactate synthase activity
HEP85_RS28100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP85_RS28115	COG0477	Major facilitator Superfamily
HEP85_RS28130	COG0506	proline dehydrogenase activity
HEP85_RS28135	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS28150	COG0473	3-isopropylmalate dehydrogenase activity
HEP85_RS28155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP85_RS28175	COG0832	Belongs to the urease beta subunit family
HEP85_RS28175	COG0831	urea catabolic process
HEP85_RS28180	COG0804	urea catabolic process
HEP85_RS28185	COG2957	Belongs to the agmatine deiminase family
HEP85_RS28195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP85_RS28225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP85_RS28245	COG2018	Roadblock/LC7 domain
HEP85_RS28265	COG2018	Roadblock/LC7 domain
HEP85_RS28280	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP85_RS28285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP85_RS28345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEP85_RS28350	COG0066	3-isopropylmalate dehydratase activity
HEP85_RS28360	COG0776	regulation of translation
HEP85_RS28370	COG1920	GTP binding
HEP85_RS28380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP85_RS28385	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP85_RS28405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEP85_RS28420	COG0326	Molecular chaperone. Has ATPase activity
HEP85_RS28425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP85_RS28430	COG0742	ribosomal rna small subunit methyltransferase
HEP85_RS28435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEP85_RS28450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HEP85_RS28455	COG0571	ribonuclease III activity
HEP85_RS28460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP85_RS28465	COG1733	regulation of RNA biosynthetic process
HEP85_RS28485	COG2340	Cysteine-rich secretory protein family
HEP85_RS28490	COG1254	Belongs to the acylphosphatase family
HEP85_RS28505	COG0477	Major facilitator Superfamily
HEP85_RS28555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP85_RS28565	COG0442	prolyl-tRNA aminoacylation
HEP85_RS28575	COG0228	four-way junction DNA binding
HEP85_RS28580	COG1837	Belongs to the UPF0109 family
HEP85_RS28585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP85_RS28590	COG0336	Belongs to the RNA methyltransferase TrmD family
HEP85_RS28595	COG0335	large ribosomal subunit rRNA binding
HEP85_RS28605	COG0681	Belongs to the peptidase S26 family
HEP85_RS28615	COG0681	Belongs to the peptidase S26 family
HEP85_RS28620	COG1051	belongs to the nudix hydrolase family
HEP85_RS28630	COG0792	nuclease activity
HEP85_RS28645	COG1191	sigma factor activity
HEP85_RS28660	COG0052	Belongs to the universal ribosomal protein uS2 family
HEP85_RS28665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP85_RS28670	COG0528	UMP kinase activity
HEP85_RS28675	COG0233	cytoplasmic translational termination
HEP85_RS28695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP85_RS28705	COG4208	sulfate ABC transporter
HEP85_RS28710	COG3842	ATPase activity
HEP85_RS28735	COG1136	(ABC) transporter
HEP85_RS28740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP85_RS28750	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS28810	COG0584	glycerophosphoryl diester phosphodiesterase
HEP85_RS28815	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP85_RS28840	COG3842	ATPase activity
HEP85_RS28845	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP85_RS28850	COG1177	transmembrane transport
HEP85_RS28885	COG2508	Transcriptional regulator
HEP85_RS28885	COG2508	Transcriptional regulator
HEP85_RS28890	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS28930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEP85_RS28935	COG0750	zinc metalloprotease
HEP85_RS28940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEP85_RS28955	COG0442	prolyl-tRNA aminoacylation
HEP85_RS28975	COG0779	Required for maturation of 30S ribosomal subunits
HEP85_RS29000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HEP85_RS29005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEP85_RS29025	COG4608	Belongs to the ABC transporter superfamily
HEP85_RS29035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP85_RS29040	COG0601	transmembrane transport
HEP85_RS29070	COG1404	Belongs to the peptidase S8 family
HEP85_RS29090	COG1404	Belongs to the peptidase S8 family
HEP85_RS29125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEP85_RS29130	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP85_RS29135	COG0612	Peptidase, M16
HEP85_RS29140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HEP85_RS29160	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HEP85_RS29165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP85_RS29170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEP85_RS29200	COG2770	Histidine kinase
HEP85_RS29200	COG2208	phosphoserine phosphatase activity
HEP85_RS29210	COG2205	protein histidine kinase activity
HEP85_RS29210	COG4999	Histidine kinase
HEP85_RS29210	COG3437	response regulator, receiver
HEP85_RS29210	COG3850	Histidine kinase
HEP85_RS29220	COG1674	ftsk spoiiie
HEP85_RS29230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP85_RS29240	COG1058	Belongs to the CinA family
HEP85_RS29240	COG1546	Belongs to the CinA family
HEP85_RS29245	COG1396	sequence-specific DNA binding
HEP85_RS29250	COG0783	Belongs to the Dps family
HEP85_RS29255	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS29260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP85_RS29270	COG2207	Transcriptional regulator
HEP85_RS29270	COG1917	Cupin 2, conserved barrel domain protein
HEP85_RS29305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP85_RS29315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEP85_RS29325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP85_RS29330	COG0765	amino acid transport
HEP85_RS29335	COG0765	amino acid transport
HEP85_RS29340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP85_RS29345	COG1126	abc transporter atp-binding protein
HEP85_RS29350	COG0745	RESPONSE REGULATOR receiver
HEP85_RS29360	COG2358	TRAP transporter, solute receptor (TAXI family
HEP85_RS29380	COG3851	Histidine kinase
HEP85_RS29385	COG2197	response regulator
HEP85_RS29405	COG0583	DNA-binding transcription factor activity
HEP85_RS29410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP85_RS29430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEP85_RS29440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEP85_RS29445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP85_RS29455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP85_RS29495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP85_RS29500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP85_RS29505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP85_RS29540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEP85_RS29580	COG2186	Transcriptional regulator
HEP85_RS29585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP85_RS29600	COG0187	DNA topoisomerase II activity
HEP85_RS29615	COG2197	response regulator
HEP85_RS29625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP85_RS29640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP85_RS29655	COG3290	protein histidine kinase activity
HEP85_RS29670	COG0372	Belongs to the citrate synthase family
HEP85_RS29690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEP85_RS29695	COG0612	Peptidase, M16
HEP85_RS29705	COG0739	heme binding
HEP85_RS29710	COG1802	Transcriptional regulator
HEP85_RS29715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP85_RS29740	COG1435	thymidine kinase activity
HEP85_RS29790	COG0745	RESPONSE REGULATOR receiver
HEP85_RS29795	COG2205	protein histidine kinase activity
HEP85_RS29820	COG0756	dUTP diphosphatase activity
HEP85_RS29835	COG1136	(ABC) transporter
HEP85_RS29835	COG0577	efflux transmembrane transporter activity
HEP85_RS29870	COG0569	domain protein
HEP85_RS29875	COG0531	amino acid
HEP85_RS29880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEP85_RS29925	COG1799	cell septum assembly
HEP85_RS29945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS29955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP85_RS29970	COG2235	arginine
HEP85_RS29975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP85_RS29980	COG0531	amino acid
HEP85_RS29990	COG1024	Enoyl-CoA hydratase
HEP85_RS30030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEP85_RS30045	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS30060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HEP85_RS30065	COG3537	Alpha-1,2-mannosidase
HEP85_RS30075	COG1653	transport
HEP85_RS30080	COG1175	transmembrane transport
HEP85_RS30085	COG0395	ABC-type sugar transport system, permease component
HEP85_RS30090	COG1940	carbohydrate kinase activity
HEP85_RS30095	COG4213	ABC transporter substrate-binding protein
HEP85_RS30105	COG4214	carbohydrate transport
HEP85_RS30110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP85_RS30115	COG0531	amino acid
HEP85_RS30135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP85_RS30135	COG1024	Enoyl-CoA hydratase
HEP85_RS30140	COG0183	Belongs to the thiolase family
HEP85_RS30145	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEP85_RS30160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP85_RS30175	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP85_RS30210	COG3220	belongs to the UPF0276 family
HEP85_RS30255	COG4221	oxidoreductase activity
HEP85_RS30260	COG2326	polyphosphate kinase activity
HEP85_RS30270	COG0330	HflC and HflK could
HEP85_RS30290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP85_RS30295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP85_RS30500	COG2409	Drug exporters of the RND superfamily
HEP85_RS30515	COG0667	Aldo Keto reductase
HEP85_RS30530	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS30540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP85_RS30545	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HEP85_RS30570	COG0529	Catalyzes the synthesis of activated sulfate
HEP85_RS30575	COG0175	sulfate reduction
HEP85_RS30620	COG4977	sequence-specific DNA binding
HEP85_RS30620	COG1917	Cupin 2, conserved barrel domain protein
HEP85_RS30655	COG0596	Alpha beta hydrolase
HEP85_RS30680	COG0277	FAD linked oxidase domain protein
HEP85_RS30705	COG1162	GTPase activity
HEP85_RS30745	COG0028	Belongs to the TPP enzyme family
HEP85_RS30765	COG1802	Transcriptional regulator
HEP85_RS30780	COG3835	regulator
HEP85_RS30795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP85_RS30800	COG2252	PERMEase
HEP85_RS30815	COG5634	Uncharacterized conserved protein (DUF2278)
HEP85_RS30820	COG0726	polysaccharide deacetylase
HEP85_RS30825	COG1132	(ABC) transporter
HEP85_RS30835	COG0596	Alpha beta hydrolase
HEP85_RS30840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP85_RS30885	COG0640	Transcriptional regulator
HEP85_RS30905	COG0297	glycogen (starch) synthase activity
HEP85_RS30910	COG0489	protein tyrosine kinase activity
HEP85_RS30925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP85_RS30930	COG0438	transferase activity, transferring glycosyl groups
HEP85_RS30945	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEP85_RS30950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP85_RS30955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEP85_RS30960	COG1316	TRANSCRIPTIONal
HEP85_RS30985	COG1309	transcriptional regulator
HEP85_RS31000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEP85_RS31005	COG0598	Magnesium transport protein CorA
HEP85_RS31030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP85_RS31035	COG0318	PFAM AMP-dependent synthetase and ligase
HEP85_RS31045	COG3960	tartronate-semialdehyde synthase activity
HEP85_RS31060	COG0753	catalase activity
HEP85_RS31065	COG2084	Dehydrogenase
HEP85_RS31070	COG3622	Belongs to the hyi family
HEP85_RS31090	COG2351	hydroxyisourate hydrolase activity
HEP85_RS31105	COG2233	PERMEase
HEP85_RS31120	COG1733	regulation of RNA biosynthetic process
HEP85_RS31130	COG0406	alpha-ribazole phosphatase activity
HEP85_RS31150	COG0436	Aminotransferase
HEP85_RS31165	COG2304	oxidoreductase activity
HEP85_RS31170	COG4264	IucA IucC family
HEP85_RS31185	COG1024	Enoyl-CoA hydratase
HEP85_RS31190	COG2124	cytochrome p450
HEP85_RS31210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP85_RS31220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP85_RS31225	COG1414	Transcriptional regulator
HEP85_RS31230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP85_RS31235	COG4266	Belongs to the allantoicase family
HEP85_RS31240	COG0598	Magnesium transport protein CorA
HEP85_RS31260	COG0667	Aldo Keto reductase
HEP85_RS31275	COG0673	inositol 2-dehydrogenase activity
HEP85_RS31280	COG2188	Transcriptional regulator
HEP85_RS31295	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP85_RS31305	COG1940	carbohydrate kinase activity
HEP85_RS31325	COG0583	DNA-binding transcription factor activity
HEP85_RS31340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HEP85_RS31350	COG1454	alcohol dehydrogenase
HEP85_RS31355	COG3485	protocatechuate 3,4-dioxygenase
HEP85_RS31375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP85_RS31380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP85_RS31395	COG1126	abc transporter atp-binding protein
HEP85_RS31405	COG0765	amino acid transport
HEP85_RS31410	COG0765	amino acid transport
HEP85_RS31425	COG0405	Gamma-glutamyltransferase
HEP85_RS31470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP85_RS31480	COG1953	Uracil, thiamine, allantoin
HEP85_RS31490	COG2226	methyltransferase
HEP85_RS31545	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP85_RS31570	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS31575	COG0583	DNA-binding transcription factor activity
HEP85_RS31580	COG4829	muconolactone delta-isomerase
HEP85_RS31590	COG1309	transcriptional regulator
HEP85_RS31625	COG0745	RESPONSE REGULATOR receiver
HEP85_RS31630	COG5002	protein histidine kinase activity
HEP85_RS31670	COG0671	phosphoesterase, PA-phosphatase related
HEP85_RS31675	COG0586	Pfam SNARE associated Golgi protein
HEP85_RS31710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP85_RS31725	COG3173	Aminoglycoside phosphotransferase
HEP85_RS31750	COG1929	Belongs to the glycerate kinase type-1 family
HEP85_RS31770	COG0559	Belongs to the binding-protein-dependent transport system permease family
HEP85_RS31775	COG0559	Belongs to the binding-protein-dependent transport system permease family
HEP85_RS31790	COG0688	phosphatidylethanolamine metabolic process
HEP85_RS31795	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS31805	COG2301	Belongs to the HpcH HpaI aldolase family
HEP85_RS31810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS31810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP85_RS31815	COG0604	alcohol dehydrogenase
HEP85_RS31825	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP85_RS31835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP85_RS31835	COG0456	acetyltransferase
HEP85_RS31845	COG0596	Alpha beta hydrolase
HEP85_RS31870	COG2226	methyltransferase
HEP85_RS31905	COG2362	D-Aminopeptidase
HEP85_RS31920	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEP85_RS31945	COG2226	methyltransferase
HEP85_RS31955	COG0488	(ABC) transporter
HEP85_RS32025	COG0443	Heat shock 70 kDa protein
HEP85_RS32045	COG1902	pentaerythritol trinitrate reductase activity
HEP85_RS32050	COG1846	Transcriptional regulator
HEP85_RS32055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP85_RS32070	COG2154	pterin-4-alpha-carbinolamine dehydratase
HEP85_RS32075	COG2226	methyltransferase
HEP85_RS32090	COG2378	regulation of single-species biofilm formation
HEP85_RS32115	COG0656	L-ascorbic acid biosynthetic process
HEP85_RS32145	COG1335	isochorismatase
HEP85_RS32150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HEP85_RS32165	COG3383	formate dehydrogenase (NAD+) activity
HEP85_RS32170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEP85_RS32175	COG0667	Aldo Keto reductase
HEP85_RS32205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP85_RS32230	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP85_RS32235	COG1879	ABC-type sugar transport system periplasmic component
HEP85_RS32240	COG0673	inositol 2-dehydrogenase activity
HEP85_RS32305	COG2223	nitrite transmembrane transporter activity
HEP85_RS32315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP85_RS32325	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP85_RS32335	COG1012	belongs to the aldehyde dehydrogenase family
HEP85_RS32380	COG0567	Dehydrogenase, E1 component
HEP85_RS32380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP85_RS32385	COG4637	Psort location Cytoplasmic, score
HEP85_RS32425	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS32430	COG3265	gluconokinase activity
HEP85_RS32465	COG3387	PFAM Glycoside hydrolase 15-related
HEP85_RS32485	COG0714	Associated with various cellular activities
HEP85_RS32535	COG0542	response to heat
HEP85_RS32575	COG2353	YceI-like domain
HEP85_RS32585	COG0765	amino acid transport
HEP85_RS32610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS32615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP85_RS32650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP85_RS32655	COG2423	ornithine cyclodeaminase activity
HEP85_RS32670	COG0477	Major facilitator Superfamily
HEP85_RS32680	COG3467	pyridoxamine 5'-phosphate
HEP85_RS32695	COG0406	alpha-ribazole phosphatase activity
HEP85_RS32705	COG0166	Belongs to the GPI family
HEP85_RS32720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP85_RS32750	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEP85_RS32760	COG1486	melibiose metabolic process
HEP85_RS32765	COG3469	chitinase activity
HEP85_RS32820	COG0006	proline dipeptidase activity
HEP85_RS32825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP85_RS32845	COG3938	Belongs to the proline racemase family
HEP85_RS32865	COG1175	transmembrane transport
HEP85_RS32870	COG0395	ABC-type sugar transport system, permease component
HEP85_RS32875	COG0366	Alpha amylase catalytic
HEP85_RS32890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP85_RS32895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP85_RS32920	COG1024	Enoyl-CoA hydratase
HEP85_RS32930	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP85_RS32935	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS32950	COG0583	DNA-binding transcription factor activity
HEP85_RS32960	COG1024	Enoyl-CoA hydratase
HEP85_RS32970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS33000	COG1278	Cold shock
HEP85_RS33030	COG3511	phospholipase C
HEP85_RS33065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP85_RS33070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEP85_RS33075	COG3485	protocatechuate 3,4-dioxygenase
HEP85_RS33080	COG3485	protocatechuate 3,4-dioxygenase
HEP85_RS33100	COG1470	cell adhesion involved in biofilm formation
HEP85_RS33105	COG1793	dna ligase
HEP85_RS33175	COG1834	amidinotransferase
HEP85_RS33180	COG0488	(ABC) transporter
HEP85_RS33200	COG1515	deoxyribonuclease V activity
HEP85_RS33210	COG3268	Saccharopine dehydrogenase
HEP85_RS33215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP85_RS33220	COG1960	acyl-CoA dehydrogenase activity
HEP85_RS33225	COG0183	Belongs to the thiolase family
HEP85_RS33230	COG1024	Enoyl-CoA hydratase
HEP85_RS33230	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP85_RS33235	COG0789	Transcriptional regulator
HEP85_RS33245	COG1113	amino acid transport
HEP85_RS33275	COG0488	(ABC) transporter
HEP85_RS33285	COG2183	response to ionizing radiation
HEP85_RS33295	COG4977	sequence-specific DNA binding
HEP85_RS33305	COG1024	Enoyl-CoA hydratase
HEP85_RS33315	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP85_RS33365	COG1134	teichoic acid transport
HEP85_RS33370	COG1562	ergosterol biosynthetic process
HEP85_RS33380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HEP85_RS33390	COG1657	PFAM Prenyltransferase squalene oxidase
HEP85_RS33405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEP85_RS33410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP85_RS33430	COG2365	Tyrosine phosphatase family
HEP85_RS33440	COG2755	lipolytic protein G-D-S-L family
HEP85_RS33450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HEP85_RS33485	COG0673	inositol 2-dehydrogenase activity
HEP85_RS33490	COG1063	alcohol dehydrogenase
HEP85_RS33495	COG0156	8-amino-7-oxononanoate synthase activity
HEP85_RS33500	COG0583	DNA-binding transcription factor activity
HEP85_RS33525	COG3958	Transketolase
HEP85_RS33530	COG3959	Transketolase, thiamine diphosphate binding domain
HEP85_RS33565	COG3033	Beta-eliminating lyase
HEP85_RS33580	COG1737	Transcriptional regulator
HEP85_RS33585	COG4821	SIS domain
HEP85_RS33595	COG0183	Belongs to the thiolase family
HEP85_RS33655	COG0351	phosphomethylpyrimidine kinase
HEP85_RS33665	COG1522	sequence-specific DNA binding
HEP85_RS33685	COG0698	ribose 5-phosphate isomerase
HEP85_RS33690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP85_RS33715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP85_RS33740	COG2838	Isocitrate dehydrogenase
HEP85_RS33745	COG0668	transmembrane transport
HEP85_RS33750	COG1024	Enoyl-CoA hydratase
HEP85_RS33760	COG1132	(ABC) transporter
HEP85_RS33765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEP85_RS33770	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEP85_RS33770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP85_RS33790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP85_RS33795	COG2080	2 iron, 2 sulfur cluster binding
HEP85_RS33805	COG0477	Major facilitator Superfamily
HEP85_RS33825	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS33845	COG1063	alcohol dehydrogenase
HEP85_RS33855	COG3387	PFAM Glycoside hydrolase 15-related
HEP85_RS33860	COG1289	transmembrane transporter activity
HEP85_RS33865	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HEP85_RS33880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HEP85_RS33905	COG0297	glycogen (starch) synthase activity
HEP85_RS33910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEP85_RS33935	COG0701	Predicted permease
HEP85_RS33985	COG1175	transmembrane transport
HEP85_RS33990	COG0395	ABC-type sugar transport system, permease component
HEP85_RS34010	COG2186	Transcriptional regulator
HEP85_RS34020	COG1129	ABC transporter
HEP85_RS34025	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP85_RS34030	COG4948	Mandelate Racemase Muconate Lactonizing
HEP85_RS34070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP85_RS34100	COG0726	polysaccharide deacetylase
HEP85_RS34140	COG2197	response regulator
HEP85_RS34150	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS34165	COG1053	succinate dehydrogenase
HEP85_RS34170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEP85_RS34195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS34205	COG0667	Aldo Keto reductase
HEP85_RS34230	COG1595	DNA-templated transcription, initiation
HEP85_RS34240	COG3360	Dodecin
HEP85_RS34265	COG4257	antibiotic catabolic process
HEP85_RS34280	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HEP85_RS34285	COG0121	glutamine amidotransferase
HEP85_RS34290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP85_RS34295	COG3572	ergothioneine biosynthetic process
HEP85_RS34310	COG2268	Band 7 protein
HEP85_RS34325	COG1609	Transcriptional regulator
HEP85_RS34340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP85_RS34350	COG0488	(ABC) transporter
HEP85_RS34355	COG0242	peptide deformylase activity
HEP85_RS34435	COG1335	isochorismatase
HEP85_RS34440	COG0477	Major facilitator Superfamily
HEP85_RS34450	COG0667	Aldo Keto reductase
HEP85_RS34460	COG0114	fumarate hydratase activity
HEP85_RS34470	COG1191	sigma factor activity
HEP85_RS34520	COG0330	HflC and HflK could
HEP85_RS34530	COG1404	Belongs to the peptidase S8 family
HEP85_RS34535	COG0671	phosphoesterase, PA-phosphatase related
HEP85_RS34565	COG0583	DNA-binding transcription factor activity
HEP85_RS34650	COG2770	Histidine kinase
HEP85_RS34650	COG2208	phosphoserine phosphatase activity
HEP85_RS34675	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEP85_RS34700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP85_RS34705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP85_RS34720	COG3250	beta-galactosidase activity
HEP85_RS34725	COG3345	alpha-galactosidase
HEP85_RS34735	COG1175	transmembrane transport
HEP85_RS34740	COG0395	ABC-type sugar transport system, permease component
HEP85_RS34755	COG2186	Transcriptional regulator
HEP85_RS34760	COG4948	Mandelate Racemase Muconate Lactonizing
HEP85_RS34770	COG0800	Aldolase
HEP85_RS34795	COG2814	Major facilitator Superfamily
HEP85_RS34810	COG2197	response regulator
HEP85_RS34835	COG1609	Transcriptional regulator
HEP85_RS34850	COG0395	ABC-type sugar transport system, permease component
HEP85_RS34985	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS34995	COG2197	response regulator
HEP85_RS35000	COG4585	Histidine kinase
HEP85_RS35030	COG3469	chitinase activity
HEP85_RS35100	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEP85_RS35125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEP85_RS35135	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEP85_RS35145	COG0298	carbon dioxide binding
HEP85_RS35155	COG0309	Hydrogenase expression formation protein (HypE)
HEP85_RS35170	COG1174	glycine betaine transport
HEP85_RS35175	COG1174	glycine betaine transport
HEP85_RS35185	COG0517	IMP dehydrogenase activity
HEP85_RS35185	COG1125	glycine betaine transport
HEP85_RS35190	COG1556	Lactate utilization protein
HEP85_RS35195	COG1139	Iron-sulfur cluster binding protein
HEP85_RS35200	COG0247	lactate metabolic process
HEP85_RS35205	COG1070	Carbohydrate kinase
HEP85_RS35210	COG3347	Dehydrogenase
HEP85_RS35210	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS35220	COG1129	ABC transporter
HEP85_RS35230	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP85_RS35250	COG1609	Transcriptional regulator
HEP85_RS35260	COG1595	DNA-templated transcription, initiation
HEP85_RS35270	COG1357	PFAM Pentapeptide repeats (8 copies)
HEP85_RS35280	COG1309	transcriptional regulator
HEP85_RS35290	COG2706	6-phosphogluconolactonase activity
HEP85_RS35375	COG1120	ATPase activity
HEP85_RS35385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP85_RS35390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEP85_RS35395	COG1611	Belongs to the LOG family
HEP85_RS35420	COG3903	Transcriptional regulator
HEP85_RS35420	COG3629	intracellular signal transduction
HEP85_RS35435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP85_RS35490	COG2205	protein histidine kinase activity
HEP85_RS35495	COG0745	RESPONSE REGULATOR receiver
HEP85_RS35515	COG0436	Aminotransferase
HEP85_RS35520	COG1024	Enoyl-CoA hydratase
HEP85_RS35525	COG2723	6-phospho-beta-galactosidase activity
HEP85_RS35530	COG0395	ABC-type sugar transport system, permease component
HEP85_RS35540	COG2182	Extracellular solute-binding protein
HEP85_RS35545	COG1940	carbohydrate kinase activity
HEP85_RS35555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HEP85_RS35555	COG1796	DNA polymerase
HEP85_RS35600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP85_RS35605	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP85_RS35625	COG2814	Major facilitator Superfamily
HEP85_RS35630	COG1063	alcohol dehydrogenase
HEP85_RS35650	COG1595	DNA-templated transcription, initiation
HEP85_RS35685	COG0675	Transposase, IS605 OrfB family
HEP85_RS35700	COG0531	amino acid
HEP85_RS35745	COG2124	cytochrome p450
HEP85_RS35775	COG1486	melibiose metabolic process
HEP85_RS35785	COG0395	ABC-type sugar transport system, permease component
HEP85_RS35795	COG2182	Extracellular solute-binding protein
HEP85_RS35805	COG0596	Alpha beta hydrolase
HEP85_RS35840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP85_RS35865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP85_RS35925	COG5265	(ABC) transporter
HEP85_RS35970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HEP85_RS35990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP85_RS36000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP85_RS36035	COG1132	(ABC) transporter
HEP85_RS36050	COG4221	oxidoreductase activity
HEP85_RS36080	COG2175	clavaminate synthase activity
HEP85_RS36085	COG2186	Transcriptional regulator
HEP85_RS36090	COG1959	2 iron, 2 sulfur cluster binding
HEP85_RS36090	COG1295	ribonuclease BN
HEP85_RS36095	COG4191	Histidine kinase
HEP85_RS36115	COG1846	Transcriptional regulator
HEP85_RS36115	COG1940	carbohydrate kinase activity
HEP85_RS36160	COG5297	Belongs to the glycosyl hydrolase family 6
HEP85_RS36170	COG1309	transcriptional regulator
HEP85_RS36180	COG0477	Major facilitator Superfamily
HEP85_RS36205	COG0667	Aldo Keto reductase
HEP85_RS36230	COG0596	Alpha beta hydrolase
HEP85_RS36300	COG0667	Aldo Keto reductase
HEP85_RS36305	COG3647	Membrane
HEP85_RS36335	COG0515	serine threonine protein kinase
HEP85_RS36345	COG3250	beta-galactosidase activity
HEP85_RS36365	COG1414	Transcriptional regulator
HEP85_RS36370	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS36375	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS36385	COG0477	Major facilitator Superfamily
HEP85_RS36450	COG3290	protein histidine kinase activity
HEP85_RS36480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP85_RS36495	COG1131	(ABC) transporter
HEP85_RS36500	COG4585	Histidine kinase
HEP85_RS36505	COG2197	response regulator
HEP85_RS36510	COG1131	(ABC) transporter
HEP85_RS36510	COG1716	ATPase activity
HEP85_RS36510	COG0842	Transport permease protein
HEP85_RS36665	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP85_RS36840	COG0542	response to heat
HEP85_RS36850	COG3835	regulator
HEP85_RS36855	COG0583	DNA-binding transcription factor activity
HEP85_RS36865	COG0656	L-ascorbic acid biosynthetic process
HEP85_RS36885	COG2186	Transcriptional regulator
HEP85_RS36895	COG1175	transmembrane transport
HEP85_RS36900	COG0395	ABC-type sugar transport system, permease component
HEP85_RS37000	COG1595	DNA-templated transcription, initiation
HEP85_RS37030	COG1764	response to oxidative stress
HEP85_RS37080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP85_RS37100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEP85_RS37120	COG0477	Major facilitator Superfamily
HEP85_RS37170	COG1672	PFAM Archaeal ATPase
HEP85_RS37170	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP85_RS37210	COG2186	Transcriptional regulator
HEP85_RS37220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEP85_RS37225	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP85_RS37240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP85_RS37245	COG2814	Major facilitator Superfamily
HEP85_RS37280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP85_RS37290	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS37325	COG0640	Transcriptional regulator
HEP85_RS37355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP85_RS37390	COG2770	Histidine kinase
HEP85_RS37390	COG2208	phosphoserine phosphatase activity
HEP85_RS37410	COG1191	sigma factor activity
HEP85_RS37420	COG2208	phosphoserine phosphatase activity
HEP85_RS37420	COG2770	Histidine kinase
HEP85_RS37425	COG0596	Alpha beta hydrolase
HEP85_RS37470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP85_RS37485	COG0783	Belongs to the Dps family
HEP85_RS37530	COG1191	sigma factor activity
HEP85_RS37535	COG1278	Cold shock
HEP85_RS37605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP85_RS37605	COG1017	nitric oxide dioxygenase activity
HEP85_RS37610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP85_RS37620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HEP85_RS37630	COG2353	YceI-like domain
HEP85_RS37650	COG1609	Transcriptional regulator
HEP85_RS37655	COG0747	negative chemotaxis
HEP85_RS37660	COG0601	transmembrane transport
HEP85_RS37665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP85_RS37670	COG0444	Belongs to the ABC transporter superfamily
HEP85_RS37700	COG2226	methyltransferase
HEP85_RS37775	COG5002	protein histidine kinase activity
HEP85_RS37880	COG4221	oxidoreductase activity
HEP85_RS37885	COG0667	Aldo Keto reductase
HEP85_RS37890	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEP85_RS37950	COG1042	CoA-binding domain protein
HEP85_RS37950	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP85_RS37950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP85_RS37975	COG0516	GMP reductase activity
HEP85_RS37975	COG0517	IMP dehydrogenase activity
HEP85_RS37995	COG1063	alcohol dehydrogenase
HEP85_RS38015	COG0549	Belongs to the carbamate kinase family
HEP85_RS38075	COG1484	DNA-dependent DNA replication
HEP85_RS38080	COG4584	PFAM Integrase catalytic
HEP85_RS38210	COG3547	Transposase (IS116 IS110 IS902 family)
HEP85_RS38220	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS38320	COG3548	integral membrane protein
HEP85_RS38330	COG2837	iron assimilation
HEP85_RS38340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP85_RS38345	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS38365	COG0745	RESPONSE REGULATOR receiver
HEP85_RS38370	COG2205	protein histidine kinase activity
HEP85_RS38680	COG0640	Transcriptional regulator
HEP85_RS38690	COG2072	flavoprotein involved in K transport
HEP85_RS38695	COG0798	PFAM Bile acid sodium symporter
HEP85_RS38710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP85_RS38740	COG1278	Cold shock
HEP85_RS38780	COG0596	Alpha beta hydrolase
HEP85_RS38785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP85_RS38795	COG0805	protein transport
HEP85_RS38895	COG0515	serine threonine protein kinase
HEP85_RS38895	COG2815	serine threonine protein kinase
HEP85_RS39065	COG0174	glutamine synthetase
HEP85_RS39260	COG0483	inositol monophosphate 1-phosphatase activity
HEP85_RS39280	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS39285	COG4221	oxidoreductase activity
HEP85_RS39360	COG3250	beta-galactosidase activity
HEP85_RS39415	COG1660	Displays ATPase and GTPase activities
HEP85_RS39420	COG2815	serine threonine protein kinase
HEP85_RS39420	COG0515	serine threonine protein kinase
HEP85_RS39425	COG0515	serine threonine protein kinase
HEP85_RS39425	COG2815	serine threonine protein kinase
HEP85_RS39540	COG1595	DNA-templated transcription, initiation
HEP85_RS39560	COG1309	transcriptional regulator
HEP85_RS39565	COG2175	clavaminate synthase activity
HEP85_RS39595	COG2319	Wd-40 repeat
HEP85_RS39595	COG4249	Peptidase C14 caspase catalytic subunit p20
HEP85_RS39600	COG0346	lactoylglutathione lyase activity
HEP85_RS39615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEP85_RS39620	COG3012	SEC-C Motif Domain Protein
HEP85_RS39700	COG0640	Transcriptional regulator
HEP85_RS39760	COG3293	Transposase
HEP85_RS39765	COG3547	Transposase (IS116 IS110 IS902 family)
HEP85_RS39795	COG0494	nUDIX hydrolase
HEP85_RS39820	COG1672	PFAM Archaeal ATPase
HEP85_RS39820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP85_RS39825	COG2197	response regulator
HEP85_RS39870	COG0165	Argininosuccinate lyase
HEP85_RS39890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP85_RS39895	COG0778	Nitroreductase
HEP85_RS39920	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS39995	COG0583	DNA-binding transcription factor activity
HEP85_RS40105	COG2770	Histidine kinase
HEP85_RS40105	COG2208	phosphoserine phosphatase activity
HEP85_RS40125	COG0604	alcohol dehydrogenase
HEP85_RS40130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP85_RS40165	COG2315	Protein conserved in bacteria
HEP85_RS40255	COG0587	DNA-directed DNA polymerase activity
HEP85_RS40295	COG4974	Belongs to the 'phage' integrase family
HEP85_RS40380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP85_RS40540	COG1522	sequence-specific DNA binding
HEP85_RS40550	COG2050	protein possibly involved in aromatic compounds catabolism
HEP85_RS40585	COG1024	Enoyl-CoA hydratase
HEP85_RS40585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEP85_RS40610	COG3293	Transposase
HEP85_RS40620	COG1484	DNA-dependent DNA replication
HEP85_RS40655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP85_RS40720	COG1302	Protein conserved in bacteria
HEP85_RS40725	COG1595	DNA-templated transcription, initiation
HEP85_RS40805	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP85_RS40830	COG4221	oxidoreductase activity
HEP85_RS40840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP85_RS40870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP85_RS40875	COG4989	oxidoreductase activity
HEP85_RS40880	COG0667	Aldo Keto reductase
HEP85_RS40885	COG0583	DNA-binding transcription factor activity
HEP85_RS40890	COG0483	inositol monophosphate 1-phosphatase activity
HEP85_RS40960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEP85_RS40985	COG4213	ABC transporter substrate-binding protein
HEP85_RS40995	COG4214	carbohydrate transport
HEP85_RS41025	COG1725	Transcriptional regulator
HEP85_RS41040	COG0326	Molecular chaperone. Has ATPase activity
HEP85_RS41075	COG1309	transcriptional regulator
HEP85_RS41085	COG3158	transport of potassium into the cell
HEP85_RS41125	COG1940	carbohydrate kinase activity
HEP85_RS41130	COG1609	Transcriptional regulator
HEP85_RS41140	COG1175	transmembrane transport
HEP85_RS41155	COG1940	carbohydrate kinase activity
HEP85_RS41170	COG0601	transmembrane transport
HEP85_RS41180	COG1846	Transcriptional regulator
HEP85_RS41180	COG1940	carbohydrate kinase activity
HEP85_RS41210	COG1404	Belongs to the peptidase S8 family
HEP85_RS41225	COG1672	PFAM Archaeal ATPase
HEP85_RS41225	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP85_RS41295	COG2124	cytochrome p450
HEP85_RS41330	COG3537	Alpha-1,2-mannosidase
HEP85_RS41385	COG1309	transcriptional regulator
HEP85_RS41425	COG3655	Transcriptional regulator
HEP85_RS41460	COG0384	phenazine biosynthesis protein PhzF
HEP85_RS41475	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP85_RS41480	COG5297	Belongs to the glycosyl hydrolase family 6
HEP85_RS41500	COG1082	Xylose isomerase domain protein TIM barrel
HEP85_RS41505	COG1063	alcohol dehydrogenase
HEP85_RS41510	COG1653	transport
HEP85_RS41520	COG0395	ABC-type sugar transport system, permease component
HEP85_RS41525	COG1940	carbohydrate kinase activity
HEP85_RS41540	COG0726	polysaccharide deacetylase
HEP85_RS41580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEP85_RS41625	COG0519	Catalyzes the synthesis of GMP from XMP
HEP85_RS41625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP85_RS41640	COG0747	negative chemotaxis
HEP85_RS41680	COG3237	CsbD-like
HEP85_RS41685	COG2272	Belongs to the type-B carboxylesterase lipase family
HEP85_RS41730	COG2268	Band 7 protein
HEP85_RS41840	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP85_RS41840	COG1672	PFAM Archaeal ATPase
HEP85_RS41885	COG0477	Major facilitator Superfamily
HEP85_RS41900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP85_RS41905	COG0254	rRNA binding
HEP85_RS41925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP85_RS41930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP85_RS41945	COG0592	DNA-directed DNA polymerase activity
HEP85_RS41960	COG4948	Mandelate Racemase Muconate Lactonizing
HEP85_RS41965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP85_RS41970	COG1414	Transcriptional regulator
HEP85_RS41985	COG0542	response to heat
HEP85_RS42000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP85_RS42005	COG0443	Heat shock 70 kDa protein
HEP85_RS42015	COG0009	L-threonylcarbamoyladenylate synthase
HEP85_RS42045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP85_RS42055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP85_RS42060	COG1191	sigma factor activity
HEP85_RS42065	COG0783	Belongs to the Dps family
HEP85_RS42085	COG2770	Histidine kinase
HEP85_RS42085	COG2208	phosphoserine phosphatase activity
HEP85_RS42165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP85_RS42170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP85_RS42220	COG2326	polyphosphate kinase activity
HEP85_RS42240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP85_RS42260	COG2124	cytochrome p450
HEP85_RS42315	COG1881	PFAM PEBP family protein
HEP85_RS42355	COG4221	oxidoreductase activity
HEP85_RS42360	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS42375	COG0604	alcohol dehydrogenase
HEP85_RS42440	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS42480	COG0187	DNA topoisomerase II activity
HEP85_RS42500	COG0300	oxidoreductase activity
HEP85_RS42525	COG0596	Alpha beta hydrolase
HEP85_RS42550	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HEP85_RS42550	COG3608	succinylglutamate desuccinylase aspartoacylase
HEP85_RS42555	COG2080	2 iron, 2 sulfur cluster binding
HEP85_RS42560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP85_RS42560	COG2010	Cytochrome c
HEP85_RS42580	COG0477	Major facilitator Superfamily
HEP85_RS42595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS42630	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP85_RS42630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP85_RS42710	COG0739	heme binding
HEP85_RS42765	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS42785	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEP85_RS42795	COG0509	glycine decarboxylation via glycine cleavage system
HEP85_RS42820	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HEP85_RS42825	COG0735	belongs to the Fur family
HEP85_RS42845	COG1414	Transcriptional regulator
HEP85_RS42850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP85_RS42865	COG1073	alpha beta
HEP85_RS42885	COG0248	Ppx GppA phosphatase
HEP85_RS42895	COG1028	Short-chain dehydrogenase reductase Sdr
HEP85_RS42910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS42920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS42925	COG4608	Belongs to the ABC transporter superfamily
HEP85_RS42930	COG0444	Belongs to the ABC transporter superfamily
HEP85_RS42935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP85_RS42940	COG0601	transmembrane transport
HEP85_RS42995	COG2197	response regulator
HEP85_RS43035	COG0243	molybdopterin cofactor binding
HEP85_RS43050	COG1271	oxidase subunit
HEP85_RS43070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP85_RS43085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP85_RS43155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS43160	COG0431	NADPH-dependent FMN reductase
HEP85_RS43165	COG1289	transmembrane transporter activity
HEP85_RS43170	COG2837	iron assimilation
HEP85_RS43190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP85_RS43230	COG1024	Enoyl-CoA hydratase
HEP85_RS43275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP85_RS43295	COG2197	response regulator
HEP85_RS43300	COG4585	Histidine kinase
HEP85_RS43325	COG0477	Major facilitator Superfamily
HEP85_RS43330	COG3591	Belongs to the peptidase S1B family
HEP85_RS43335	COG1414	Transcriptional regulator
HEP85_RS43340	COG3485	protocatechuate 3,4-dioxygenase
HEP85_RS43350	COG0402	S-adenosylhomocysteine deaminase activity
HEP85_RS43395	COG0640	Transcriptional regulator
HEP85_RS43405	COG3979	chitinase
HEP85_RS43435	COG3537	Alpha-1,2-mannosidase
HEP85_RS43485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP85_RS43500	COG1609	Transcriptional regulator
HEP85_RS43505	COG1879	ABC-type sugar transport system periplasmic component
HEP85_RS43510	COG1129	ABC transporter
HEP85_RS43515	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP85_RS43520	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP85_RS43535	COG0738	Major facilitator superfamily
HEP85_RS43600	COG3961	Belongs to the TPP enzyme family
HEP85_RS43630	COG1295	ribonuclease BN
HEP85_RS43640	COG4251	negative regulation of phosphorylation
HEP85_RS43645	COG0784	Response regulator, receiver
HEP85_RS43655	COG0596	Alpha beta hydrolase