locus-tag class description HYQ63_RS00025 ENOG4105FDF Could be involved in DNA repair (By similarity) HYQ63_RS00040 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HYQ63_RS00150 ENOG4105CUV Homoserine Kinase HYQ63_RS00160 ENOG4105ES4 Nitrilase HYQ63_RS00215 ENOG4105FDF Could be involved in DNA repair (By similarity) HYQ63_RS00270 ENOG4105C7H Helicase, RecD TraA family HYQ63_RS00415 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HYQ63_RS00420 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HYQ63_RS00475 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HYQ63_RS00485 ENOG4105CBD Diacylglycerol kinase HYQ63_RS00530 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HYQ63_RS00535 ENOG4108ZP8 Acetolactate synthase small subunit HYQ63_RS00580 ENOG4107SJ9 decarboxylase HYQ63_RS00710 ENOG4105FDF Could be involved in DNA repair (By similarity) HYQ63_RS00845 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HYQ63_RS00850 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS00895 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS00900 ENOG4105BZU Histidine kinase HYQ63_RS00910 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HYQ63_RS01140 ENOG41087PP glycosyltransferase MGT family HYQ63_RS01145 ENOG4105C6Y Udp-glucose 6-dehydrogenase HYQ63_RS01170 ENOG41087PP glycosyltransferase MGT family HYQ63_RS01180 ENOG4105CJ1 ABC, transporter HYQ63_RS01195 ENOG4108JA1 polyketide synthase HYQ63_RS01195 ENOG4108JA1 polyketide synthase HYQ63_RS01230 ENOG4108ZXC Two component transcriptional regulator, luxr family HYQ63_RS01240 ENOG4105E98 transcriptional regulator DeoR family HYQ63_RS01275 ENOG4105CG3 alpha amylase, catalytic region HYQ63_RS01280 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HYQ63_RS01285 ENOG4108UW5 maltose o-acetyltransferase HYQ63_RS01325 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HYQ63_RS01345 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS01400 ENOG4105CJA serine threonine protein kinase HYQ63_RS01450 ENOG4107SNV Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HYQ63_RS01455 ENOG4105JXH GntR family transcriptional regulator HYQ63_RS01480 ENOG4107RDB Major Facilitator HYQ63_RS01490 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase HYQ63_RS01510 ENOG4108KQ5 Integrase catalytic subunit HYQ63_RS01540 ENOG41073TP transcriptional regulator HYQ63_RS01545 ENOG4105EXW epimerase dehydratase HYQ63_RS01550 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HYQ63_RS01555 ENOG4105CSP Major Facilitator Superfamily HYQ63_RS01560 ENOG4105FB2 class II Aldolase HYQ63_RS01565 ENOG4105G63 Type III effector Hrp-dependent HYQ63_RS01570 ENOG4105ZXK Dehydrogenase HYQ63_RS01600 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS01610 ENOG4105C7W Xanthine dehydrogenase HYQ63_RS01615 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HYQ63_RS01620 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HYQ63_RS01630 ENOG4108KQ5 Integrase catalytic subunit HYQ63_RS01645 ENOG4105CXN decarboxylase HYQ63_RS01680 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HYQ63_RS01685 ENOG4105EHG Permease protein HYQ63_RS01690 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS01740 ENOG4105CSH Transporter HYQ63_RS01765 ENOG4107QNK )-transporter HYQ63_RS01770 ENOG4105CNT hydrolase family 2 HYQ63_RS01785 ENOG4107HP6 Transcriptional regulator HYQ63_RS01790 ENOG4105MSY salicylate hydroxylase HYQ63_RS01855 ENOG4105Q56 cytochrome P450 HYQ63_RS01865 ENOG4107HP6 Transcriptional regulator HYQ63_RS01880 ENOG4107ZBH radical SAM domain protein HYQ63_RS01905 ENOG4108IJ0 Aspartate ammonia-lyase HYQ63_RS01910 ENOG4106NZI LysR family Transcriptional regulator HYQ63_RS01925 ENOG4108HMN Caspase domain HYQ63_RS01950 ENOG4105CSH Transporter HYQ63_RS01975 ENOG4105EJQ L-serine dehydratase HYQ63_RS01985 ENOG4105F76 Sarcosine oxidase HYQ63_RS02005 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HYQ63_RS02025 ENOG4105DVW rieske (2Fe-2S) HYQ63_RS02060 ENOG4105CSH Transporter HYQ63_RS02075 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HYQ63_RS02080 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HYQ63_RS02145 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HYQ63_RS02160 ENOG4105C54 Major Facilitator superfamily HYQ63_RS02165 ENOG4105C1Q protoporphyrinogen oxidase HYQ63_RS02170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYQ63_RS02175 ENOG4105C26 Dehydrogenase HYQ63_RS02190 ENOG4107RA9 decarboxylase HYQ63_RS02215 ENOG4105DRS transport system, permease HYQ63_RS02235 ENOG41060NJ transcriptional regulator HYQ63_RS02245 ENOG4107TPY serine threonine protein kinase HYQ63_RS02270 ENOG4105MWK D-amino acid dehydrogenase, small subunit HYQ63_RS02280 ENOG4105E5Q amino acid AbC transporter HYQ63_RS02305 ENOG4105CSR polyphosphate kinase 2 HYQ63_RS02320 ENOG4105ERH Fumarylacetoacetate hydrolase HYQ63_RS02325 ENOG4105CHR reductase HYQ63_RS02330 ENOG4105CQB FAD linked oxidase domain protein HYQ63_RS02335 ENOG4107R11 Transcriptional regulator HYQ63_RS02340 ENOG4105CUB amino acid HYQ63_RS02355 ENOG4105CAS nag kinase HYQ63_RS02370 ENOG4105E93 esterase HYQ63_RS02375 ENOG4105BZ1 (ABC) transporter HYQ63_RS02385 ENOG4105BZ1 (ABC) transporter HYQ63_RS02390 ENOG4108MES Periplasmic binding protein HYQ63_RS02395 ENOG4105E0A ABC, transporter HYQ63_RS02400 ENOG4105TVJ transport system, permease HYQ63_RS02405 ENOG4105DQ5 transport system permease protein HYQ63_RS02420 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HYQ63_RS02430 ENOG4107QNK )-transporter HYQ63_RS02445 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS02460 ENOG4105JQZ Methyltransferase HYQ63_RS02465 ENOG4105DDW LysR family Transcriptional regulator HYQ63_RS02480 ENOG4105DKQ ROK family HYQ63_RS02490 ENOG4107RTD sua5 ycio yrdc ywlc family protein HYQ63_RS02505 ENOG4107QSI ABC, transporter HYQ63_RS02515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS02520 ENOG4105C3U ABC transporter HYQ63_RS02525 ENOG4108JQ7 (ABC) transporter HYQ63_RS02565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS02570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYQ63_RS02575 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HYQ63_RS02585 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYQ63_RS02590 ENOG4105CQB FAD linked oxidase domain protein HYQ63_RS02595 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS02600 ENOG4108UMI ABC transporter, permease HYQ63_RS02640 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HYQ63_RS02645 ENOG4105E5Q amino acid AbC transporter HYQ63_RS02760 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HYQ63_RS02765 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HYQ63_RS02795 ENOG4105D74 hydrolase HYQ63_RS02820 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HYQ63_RS02825 ENOG4105E2D ec 3.2.1.52 HYQ63_RS02830 ENOG4105CI0 Citrate lyase HYQ63_RS02835 ENOG4108M9J MaoC like domain protein HYQ63_RS02840 ENOG4105C26 Dehydrogenase HYQ63_RS02855 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HYQ63_RS02860 ENOG4105DND Transcriptional regulator HYQ63_RS02865 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HYQ63_RS02870 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS02880 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HYQ63_RS02890 ENOG4107RSM transcriptional regulator HYQ63_RS02900 ENOG4105DDC Oxidoreductase domain protein HYQ63_RS02910 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HYQ63_RS02920 ENOG4105CIK Amidinotransferase HYQ63_RS02925 ENOG4105C8Y Acetylornithine aminotransferase HYQ63_RS02930 ENOG4108ZFD Antibiotic biosynthesis monooxygenase HYQ63_RS02940 ENOG4108ES0 acetoacetyl-CoA synthetase HYQ63_RS02950 ENOG4107SCK Monooxygenase HYQ63_RS02960 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HYQ63_RS02975 ENOG4105JXH GntR family transcriptional regulator HYQ63_RS02985 ENOG4105CXK mandelate racemase muconate lactonizing HYQ63_RS02995 ENOG4105CSH Transporter HYQ63_RS03000 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HYQ63_RS03015 ENOG4105CFG Acts as a chaperone (By similarity) HYQ63_RS03030 ENOG4108IGT Dipeptidase HYQ63_RS03060 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HYQ63_RS03065 ENOG4105C26 Dehydrogenase HYQ63_RS03070 ENOG4105DRR Transcriptional regulator, GntR family HYQ63_RS03085 ENOG4105CSH Transporter HYQ63_RS03090 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HYQ63_RS03105 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HYQ63_RS03120 ENOG4105DCG PHP domain protein HYQ63_RS03140 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HYQ63_RS03145 ENOG4105E98 transcriptional regulator DeoR family HYQ63_RS03150 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HYQ63_RS03155 ENOG4105D2N Aldolase HYQ63_RS03180 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HYQ63_RS03200 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HYQ63_RS03240 ENOG4105F2C Acetyl-CoA acetyltransferase HYQ63_RS03245 ENOG4108RZE Tetr family transcriptional regulator HYQ63_RS03255 ENOG4105CC9 acyl-Coa dehydrogenase HYQ63_RS03260 ENOG4105D2B acyl-CoA dehydrogenase HYQ63_RS03265 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS03275 ENOG4105CSU acyl-Coa dehydrogenase HYQ63_RS03285 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYQ63_RS03300 ENOG4105WKW Pfam:DUF1458 HYQ63_RS03310 ENOG4108HHA Transketolase HYQ63_RS03315 ENOG4105CEP NADH dehydrogenase HYQ63_RS03335 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS03355 ENOG4105PGM cation diffusion facilitator family transporter HYQ63_RS03365 ENOG4105CTK cobaltochelatase, cobn subunit HYQ63_RS03375 ENOG41081F0 Precorrin-8x methylmutase HYQ63_RS03390 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HYQ63_RS03400 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HYQ63_RS03405 ENOG4108UW5 maltose o-acetyltransferase HYQ63_RS03455 ENOG4108IAJ Nad-dependent epimerase dehydratase HYQ63_RS03465 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HYQ63_RS03485 ENOG4107SCK Monooxygenase HYQ63_RS03515 ENOG4105CSH Transporter HYQ63_RS03520 ENOG4108KXV response regulator HYQ63_RS03525 ENOG4105EB3 Histidine kinase HYQ63_RS03530 ENOG4105H1G trap transporter solute receptor taxi family HYQ63_RS03555 ENOG41062D9 Histidine kinase HYQ63_RS03560 ENOG4105ETX regulatoR HYQ63_RS03565 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HYQ63_RS03585 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HYQ63_RS03590 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HYQ63_RS03610 ENOG4105D8V Glucose sorbosone dehydrogenase HYQ63_RS03640 ENOG4108W6C Dehydrogenase HYQ63_RS03650 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYQ63_RS03675 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS03680 ENOG4105BZU Histidine kinase HYQ63_RS03695 ENOG4105D4T Citrate transporter HYQ63_RS03700 ENOG4106NZI LysR family Transcriptional regulator HYQ63_RS03705 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HYQ63_RS03715 ENOG4108KPJ rna polymerase sigma factor HYQ63_RS03730 ENOG4108V06 Glutathione peroxidase HYQ63_RS03740 ENOG4108YYC ycei family HYQ63_RS03835 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HYQ63_RS03845 ENOG4107UEK pfkb domain protein HYQ63_RS03850 ENOG4105E98 transcriptional regulator DeoR family HYQ63_RS03855 ENOG4105F8D glycoside hydrolase family 4 HYQ63_RS03880 ENOG4105CPQ Dehydrogenase HYQ63_RS03895 ENOG410804X Transcriptional regulator HYQ63_RS03910 ENOG4105C9U ATP-dependent DNA helicase RecQ HYQ63_RS03935 ENOG4105C6F GntR Family Transcriptional Regulator HYQ63_RS03950 ENOG4105CHR reductase HYQ63_RS03975 ENOG4105DRP amino acid AbC transporter HYQ63_RS04000 ENOG41080HT Transcriptional regulator, arsr family HYQ63_RS04005 ENOG4108XNA Gas vesicle HYQ63_RS04010 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HYQ63_RS04020 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HYQ63_RS04040 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HYQ63_RS04055 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS04065 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HYQ63_RS04070 ENOG4105DRS transport system, permease HYQ63_RS04080 ENOG4105E2A Dehydrogenase HYQ63_RS04085 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HYQ63_RS04090 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HYQ63_RS04095 ENOG4105QE3 oxidoreductase HYQ63_RS04100 ENOG4107QRI Phosphoketolase HYQ63_RS04105 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HYQ63_RS04110 ENOG4108YV4 Universal stress protein HYQ63_RS04115 ENOG4105E2A Dehydrogenase HYQ63_RS04125 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HYQ63_RS04170 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HYQ63_RS04185 ENOG4105EUB pirin domain protein HYQ63_RS04190 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HYQ63_RS04210 ENOG4108JQ1 Dehydrogenase HYQ63_RS04215 ENOG4105DRS transport system, permease HYQ63_RS04220 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HYQ63_RS04230 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS04280 ENOG4107VXZ Hydrolase HYQ63_RS04290 ENOG41064MX Tetr family transcriptional regulator HYQ63_RS04295 ENOG4108K8S endonuclease I HYQ63_RS04300 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HYQ63_RS04310 ENOG4105CPC Aldo Keto reductase HYQ63_RS04325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS04340 ENOG4107S2N Type III effector Hrp-dependent HYQ63_RS04345 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HYQ63_RS04350 ENOG410804X Transcriptional regulator HYQ63_RS04370 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYQ63_RS04385 ENOG4105DQE DNA ligase HYQ63_RS04390 ENOG4105ECQ AraC Family Transcriptional Regulator HYQ63_RS04415 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HYQ63_RS04420 ENOG4107S9F NmrA family HYQ63_RS04470 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HYQ63_RS04475 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS04485 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HYQ63_RS04495 ENOG4105F1K Glutamine amidotransferase HYQ63_RS04500 ENOG4105CTQ phosphohexokinase HYQ63_RS04550 ENOG4105J7D transcriptional regulator HYQ63_RS04570 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HYQ63_RS04580 ENOG4105CQM Urea amidohydrolase subunit alpha HYQ63_RS04585 ENOG4105KI2 Urea amidohydrolase subunit beta HYQ63_RS04590 ENOG4108YZ9 Urea amidohydrolase subunit gamma HYQ63_RS04595 ENOG4105IIU Aminopeptidase HYQ63_RS04615 ENOG4105K4H Nlp p60 protein HYQ63_RS04655 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HYQ63_RS04660 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HYQ63_RS04665 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HYQ63_RS04670 ENOG4107SK7 Sarcosine-dimethylglycine methyltransferase HYQ63_RS04685 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HYQ63_RS04725 ENOG4105C83 adenylosuccinate lyase HYQ63_RS04730 ENOG4108VCA G U mismatch-specific DNA glycosylase HYQ63_RS04740 ENOG4105DKQ ROK family HYQ63_RS04745 ENOG4105FDP GntR family transcriptional regulator HYQ63_RS04750 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HYQ63_RS04785 ENOG4105EYH Exonuclease HYQ63_RS04800 ENOG4107B2H carbonic anhydrase HYQ63_RS04805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYQ63_RS04810 ENOG4105DHQ Histidine kinase HYQ63_RS04860 ENOG4105K4P CoA-binding domain protein HYQ63_RS04885 ENOG4108Z0R Transferase HYQ63_RS04915 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HYQ63_RS04925 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HYQ63_RS04935 ENOG4107RT4 flavin reductase domain protein HYQ63_RS04940 ENOG4107S2E monooxygenase HYQ63_RS04945 ENOG4105DXI Major Facilitator superfamily HYQ63_RS04985 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HYQ63_RS04990 ENOG4105ECP epimerase HYQ63_RS04995 ENOG4105CNN ABC, transporter HYQ63_RS05005 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HYQ63_RS05015 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS05070 ENOG4105CPQ Dehydrogenase HYQ63_RS05075 ENOG4107EDW L-fucose operon activator HYQ63_RS05090 ENOG4105EMU Dehydrogenase HYQ63_RS05115 ENOG4105CHU acetyl-coa acetyltransferase HYQ63_RS05120 ENOG4105D5P Methylmalonyl-coA mutase HYQ63_RS05125 ENOG4105C10 Electron transfer flavoprotein HYQ63_RS05160 ENOG4105CHR reductase HYQ63_RS05165 ENOG4105CHR reductase HYQ63_RS05180 ENOG4105IKQ hydratase HYQ63_RS05190 ENOG4105C54 Major Facilitator superfamily HYQ63_RS05200 ENOG4107HP6 Transcriptional regulator HYQ63_RS05225 ENOG4105E39 Enoyl-CoA hydratase HYQ63_RS05235 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS05265 ENOG4108KPJ rna polymerase sigma factor HYQ63_RS05290 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HYQ63_RS05300 ENOG4105DEG Vwa containing coxe family protein HYQ63_RS05325 ENOG4105CPF Cell wall formation (By similarity) HYQ63_RS05345 ENOG4107UWN reductase HYQ63_RS05350 ENOG4105CHR reductase HYQ63_RS05365 ENOG4105BZU Histidine kinase HYQ63_RS05390 ENOG4105CVN desaturase HYQ63_RS05415 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HYQ63_RS05425 ENOG410880H cysteine synthase HYQ63_RS05450 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYQ63_RS05460 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS05465 ENOG4105KDC 50s ribosomal protein l28 HYQ63_RS05470 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HYQ63_RS05475 ENOG4105E1V na solute symporter HYQ63_RS05480 ENOG4106CAD Protein of unknown function (DUF3311) HYQ63_RS05490 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HYQ63_RS05495 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HYQ63_RS05500 ENOG41060W2 glyoxylate carboligase HYQ63_RS05505 ENOG4105DHG Allantoate amidinohydrolase HYQ63_RS05530 ENOG4105C85 amino acid HYQ63_RS05580 ENOG4108IJ0 Aspartate ammonia-lyase HYQ63_RS05595 ENOG41073TP transcriptional regulator HYQ63_RS05600 ENOG4105DIA mandelate racemase muconate lactonizing HYQ63_RS05610 ENOG4105C2J ABC transporter HYQ63_RS05615 ENOG4105CNN ABC, transporter HYQ63_RS05625 ENOG4107U7Q Transfers the fatty acyl group on membrane lipoproteins (By similarity) HYQ63_RS05630 ENOG4105EP9 oxidoreductase HYQ63_RS05660 ENOG4105D29 Helix-turn-helix type 11 domain protein HYQ63_RS05670 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HYQ63_RS05675 ENOG4105CHR reductase HYQ63_RS05695 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HYQ63_RS05700 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HYQ63_RS05720 ENOG4106P55 Transcriptional regulator HYQ63_RS05730 ENOG4105CSW GntR family transcriptional regulator HYQ63_RS05760 ENOG4105NTW Transcriptional regulator HYQ63_RS05765 ENOG4107TIF Phenazine biosynthesis protein, PhzF family HYQ63_RS05795 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HYQ63_RS05805 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HYQ63_RS05875 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HYQ63_RS05885 ENOG4105MWK D-amino acid dehydrogenase, small subunit HYQ63_RS05890 ENOG4105CDA abc transporter atp-binding protein HYQ63_RS05895 ENOG4105EAD ABC transporter HYQ63_RS05900 ENOG4105EAB amino acid AbC transporter HYQ63_RS05910 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HYQ63_RS05920 ENOG4108UQS dipeptidase HYQ63_RS05925 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HYQ63_RS05930 ENOG4105D81 ABC transporter, permease HYQ63_RS05935 ENOG4107TYH extracellular solute-binding protein family 1 HYQ63_RS05940 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS05950 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HYQ63_RS05965 ENOG4105GWZ Roadblock lc7 family protein HYQ63_RS05985 ENOG4105VQD rieske 2fe-2S domain-containing protein HYQ63_RS06005 ENOG4105DVW rieske (2Fe-2S) HYQ63_RS06015 ENOG4105CUB amino acid HYQ63_RS06035 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HYQ63_RS06055 ENOG4105E7W lamb ycsf family protein HYQ63_RS06060 ENOG4105P4J Allophanate hydrolase, subunit 1 HYQ63_RS06075 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HYQ63_RS06105 ENOG4108MJN Glycosyl Transferase HYQ63_RS06155 ENOG4108X7A Terpene synthase metal-binding domain-containing protein HYQ63_RS06185 ENOG4105E39 Enoyl-CoA hydratase HYQ63_RS06225 ENOG4108JNI Alpha beta hydrolase HYQ63_RS06255 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS06260 ENOG4108IG5 Transcriptional regulator HYQ63_RS06285 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYQ63_RS06290 ENOG4105E1F short-chain dehydrogenase reductase HYQ63_RS06295 ENOG4105X7H acyl-CoA dehydrogenase HYQ63_RS06305 ENOG4105CMT Dihydroxyacetone kinase HYQ63_RS06310 ENOG4108UTZ Dihydroxyacetone kinase HYQ63_RS06315 ENOG4105VDH Dihydroxyacetone kinase HYQ63_RS06370 ENOG4105QVC MOSC domain-containing protein HYQ63_RS06405 ENOG4106F1P AAA ATPase, central domain protein HYQ63_RS06415 ENOG4105MVE transcriptional regulator HYQ63_RS06455 ENOG4105E2R ROK family HYQ63_RS06460 ENOG4106UW1 Major Facilitator superfamily HYQ63_RS06480 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS06485 ENOG4105BZU Histidine kinase HYQ63_RS06495 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HYQ63_RS06500 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HYQ63_RS06505 ENOG4105I1F Resistance protein HYQ63_RS06525 ENOG4105EX0 alpha-galactosidase HYQ63_RS06530 ENOG4105D9P serine threonine protein kinase HYQ63_RS06540 ENOG41060NJ transcriptional regulator HYQ63_RS06565 ENOG4105C10 Electron transfer flavoprotein HYQ63_RS06585 ENOG4105E9Q Acyl-transferase HYQ63_RS06590 ENOG4105C5W Aldolase HYQ63_RS06605 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HYQ63_RS06610 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HYQ63_RS06625 ENOG4108UMN azlc family HYQ63_RS06630 ENOG4108IMY Transcriptional regulator HYQ63_RS06645 ENOG410841Q phosphoesterase PA-phosphatase related protein HYQ63_RS06650 ENOG4105EUB pirin domain protein HYQ63_RS06685 ENOG4108KQ5 Integrase catalytic subunit HYQ63_RS06700 ENOG4105BZ1 (ABC) transporter HYQ63_RS06705 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HYQ63_RS06735 ENOG4105CIR epoxide hydrolase HYQ63_RS06770 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HYQ63_RS06775 ENOG4107RSM transcriptional regulator HYQ63_RS06780 ENOG4105CHU acetyl-coa acetyltransferase HYQ63_RS06790 ENOG4107QNJ CoA-transferase subunit B HYQ63_RS06805 ENOG4107NQ8 LysR family Transcriptional regulator HYQ63_RS06830 ENOG4105CQB FAD linked oxidase domain protein HYQ63_RS06855 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HYQ63_RS06875 ENOG4106NZI LysR family Transcriptional regulator HYQ63_RS06890 ENOG41082JN Transcriptional regulator HYQ63_RS06910 ENOG4105YVS arsR family transcriptional regulator HYQ63_RS06915 ENOG4105EYF MMPL domain protein HYQ63_RS06920 ENOG4105BZU Histidine kinase HYQ63_RS06925 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS06935 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HYQ63_RS06955 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HYQ63_RS06965 ENOG4108RYR transcriptional regulator AsnC family HYQ63_RS06970 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HYQ63_RS06995 ENOG4105C7W Xanthine dehydrogenase HYQ63_RS07000 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HYQ63_RS07005 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HYQ63_RS07025 ENOG4105MP9 class II Aldolase HYQ63_RS07065 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HYQ63_RS07075 ENOG41063TF transcriptional regulator (AraC HYQ63_RS07105 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HYQ63_RS07125 ENOG4107ZED Uncharacterised protein family UPF0047 HYQ63_RS07130 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HYQ63_RS07135 ENOG4105E2Y ABC, transporter HYQ63_RS07145 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HYQ63_RS07175 ENOG4105H3G oxidoreductase HYQ63_RS07180 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS07185 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS07205 ENOG4105F5R ABC transporter HYQ63_RS07210 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HYQ63_RS07215 ENOG4105C2J ABC transporter HYQ63_RS07235 ENOG4105DET Rhamnulokinase HYQ63_RS07240 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HYQ63_RS07245 ENOG4107QR9 Iron-sulfur cluster binding protein HYQ63_RS07250 ENOG41080R8 Conserved Protein HYQ63_RS07300 ENOG4105VUF Transcriptional regulator HYQ63_RS07345 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HYQ63_RS07355 ENOG4105CDA abc transporter atp-binding protein HYQ63_RS07360 ENOG4105E5Q amino acid AbC transporter HYQ63_RS07370 ENOG4108HW3 (ABC) transporter HYQ63_RS07375 ENOG4107HP6 Transcriptional regulator HYQ63_RS07410 ENOG4105DRS transport system, permease HYQ63_RS07420 ENOG4105E2R ROK family HYQ63_RS07430 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HYQ63_RS07440 ENOG4105JXB ankyrin repeat-containing protein HYQ63_RS07455 ENOG41073TP transcriptional regulator HYQ63_RS07465 ENOG4105Q70 HYQ63_RS07470 ENOG4105FS0 cytoplasmic membrane protein HYQ63_RS07490 ENOG4105GND monovalent cation H antiporter subunit B HYQ63_RS07495 ENOG4105MKQ Monovalent cation H antiporter subunit C HYQ63_RS07500 ENOG4105C8S subunit m HYQ63_RS07510 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HYQ63_RS07525 ENOG4105EW9 transcriptional regulator AsnC family HYQ63_RS07535 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS07550 ENOG4107RR1 TRANSCRIPTIONal HYQ63_RS07555 ENOG4105C26 Dehydrogenase HYQ63_RS07580 ENOG4107VHA regulatoR HYQ63_RS07590 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HYQ63_RS07595 ENOG4105CXK mandelate racemase muconate lactonizing HYQ63_RS07600 ENOG4105DRR Transcriptional regulator, GntR family HYQ63_RS07660 ENOG4105RV9 Transcriptional regulator HYQ63_RS07665 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS07685 ENOG4105EG6 Saccharopine dehydrogenase HYQ63_RS07695 ENOG4105DYW oxidoreductase HYQ63_RS07730 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS07760 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HYQ63_RS07785 ENOG4108RJS alcohol dehydrogenase HYQ63_RS07805 ENOG4105CJA serine threonine protein kinase HYQ63_RS07815 ENOG4108IUX (ABC) transporter HYQ63_RS07920 ENOG4108Z40 Transcriptional regulator HYQ63_RS07925 ENOG4108IND Tetr family transcriptional regulator HYQ63_RS07930 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HYQ63_RS07935 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HYQ63_RS07955 ENOG4108TKH Nitroreductase HYQ63_RS07980 ENOG4105CSH Transporter HYQ63_RS08000 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS08010 ENOG4108RTU Aldolase HYQ63_RS08030 ENOG4105E39 Enoyl-CoA hydratase HYQ63_RS08045 ENOG4107XWI flavin reductase domain protein, FMN-binding HYQ63_RS08115 ENOG4107R16 Multicopper oxidase HYQ63_RS08160 ENOG410880H cysteine synthase HYQ63_RS08170 ENOG4108JQ1 Dehydrogenase HYQ63_RS08185 ENOG4105F5W AtP-binding protein HYQ63_RS08190 ENOG4106IJN integrase catalytic domain-containing protein HYQ63_RS08260 ENOG41090WU lipolytic protein G-D-S-L family HYQ63_RS08265 ENOG4105DQ4 alcohol dehydrogenase HYQ63_RS08290 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS08305 ENOG4105EX0 alpha-galactosidase HYQ63_RS08350 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HYQ63_RS08360 ENOG4105CHR reductase HYQ63_RS08365 ENOG4105CXK mandelate racemase muconate lactonizing HYQ63_RS08375 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HYQ63_RS08410 ENOG4107TTA Xylose isomerase domain protein TIM barrel HYQ63_RS08420 ENOG4105CNN ABC, transporter HYQ63_RS08425 ENOG4105CNN ABC, transporter HYQ63_RS08430 ENOG4105C2J ABC transporter HYQ63_RS08450 ENOG4107S46 esterase, PHB depolymerase HYQ63_RS08475 ENOG4105CKI cobalamin synthesis protein HYQ63_RS08480 ENOG41068HZ 50S ribosomal protein L32 HYQ63_RS08490 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HYQ63_RS08495 ENOG4105KDC 50s ribosomal protein l28 HYQ63_RS08505 ENOG4105NRA 50s ribosomal protein l31 type b HYQ63_RS08515 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HYQ63_RS08525 ENOG41066UM arsR family transcriptional regulator HYQ63_RS08540 ENOG4105CKI cobalamin synthesis protein HYQ63_RS08555 ENOG4108PJD permease HYQ63_RS08580 ENOG4105FDK ABC transporter HYQ63_RS08605 ENOG4108HCJ Hydrolase HYQ63_RS08610 ENOG4105E2R ROK family HYQ63_RS08640 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HYQ63_RS08660 ENOG41072TH Protein of unknown function (DUF1479) HYQ63_RS08705 ENOG4108IND Tetr family transcriptional regulator HYQ63_RS08850 ENOG4105FUY alpha subunit HYQ63_RS08855 ENOG4106A3M Cytochrome p-450 HYQ63_RS08875 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HYQ63_RS08910 ENOG4105DXX methyltransferase HYQ63_RS08980 ENOG4108Z4X TRANSCRIPTIONal HYQ63_RS08995 ENOG4105E5G Alpha beta hydrolase fold HYQ63_RS09000 ENOG4105CI2 imidazolone-5-propionate hydrolase HYQ63_RS09025 ENOG4108IJ7 Glycine betaine HYQ63_RS09030 ENOG4105HFS 5'-3' exonuclease HYQ63_RS09055 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HYQ63_RS09060 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HYQ63_RS09080 ENOG4108FFZ Transcriptional regulator HYQ63_RS09090 ENOG4108V1T peptidylprolyl cis-trans isomerase HYQ63_RS09095 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HYQ63_RS09105 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS09110 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HYQ63_RS09115 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HYQ63_RS09125 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HYQ63_RS09130 ENOG4105E5F proteasome HYQ63_RS09135 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HYQ63_RS09165 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS09180 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HYQ63_RS09185 ENOG4105C3R Methionine synthase HYQ63_RS09190 ENOG4108K8U Glycerol operon regulatory protein HYQ63_RS09195 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HYQ63_RS09200 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HYQ63_RS09205 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HYQ63_RS09215 ENOG4105JXH GntR family transcriptional regulator HYQ63_RS09230 ENOG4108HWV )-transporter HYQ63_RS09250 ENOG4105DIA mandelate racemase muconate lactonizing HYQ63_RS09260 ENOG4105C8N cysteinyl-tRNA synthetase HYQ63_RS09275 ENOG4108RH7 phosphoglycerate mutase HYQ63_RS09280 ENOG4105D7N magnesium and cobalt transport protein CorA HYQ63_RS09290 ENOG4105DYW oxidoreductase HYQ63_RS09295 ENOG4105CPC Aldo Keto reductase HYQ63_RS09320 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HYQ63_RS09355 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HYQ63_RS09375 ENOG4107QJN gtp cyclohydrolase ii HYQ63_RS09380 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HYQ63_RS09385 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HYQ63_RS09390 ENOG4105C7W Xanthine dehydrogenase HYQ63_RS09405 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HYQ63_RS09415 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HYQ63_RS09430 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein HYQ63_RS09440 ENOG4105PTV Nudix Hydrolase HYQ63_RS09445 ENOG4105VG5 Membrane HYQ63_RS09450 ENOG4105JP4 Inner membrane protein yidG HYQ63_RS09455 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HYQ63_RS09465 ENOG4105KVH Transcriptional regulator HYQ63_RS09475 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS09480 ENOG4108IG5 Transcriptional regulator HYQ63_RS09485 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS09490 ENOG4108R85 Short chain dehydrogenase HYQ63_RS09535 ENOG4105D4T Citrate transporter HYQ63_RS09540 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HYQ63_RS09545 ENOG4108SGK Tetr family transcriptional regulator HYQ63_RS09550 ENOG4105F1J Homogentisate 1,2-dioxygenase HYQ63_RS09585 ENOG4107TPY serine threonine protein kinase HYQ63_RS09605 ENOG4106WTF Glycosyl transferase, family 2 HYQ63_RS09635 ENOG4106V2I dimethylaminohydrolase HYQ63_RS09640 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HYQ63_RS09655 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HYQ63_RS09670 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS09675 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HYQ63_RS09680 ENOG4105DBM Siderophore biosynthesis protein HYQ63_RS09715 ENOG4105K56 Transcriptional regulator HYQ63_RS09720 ENOG4108ZHJ Organic hydroperoxide resistance protein HYQ63_RS09725 ENOG4108NIW Leucine export protein LeuE HYQ63_RS09735 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HYQ63_RS09740 ENOG4105C0B DNA polymerase III (alpha subunit) HYQ63_RS09745 ENOG410905P Pyridoxamine 5-phosphate HYQ63_RS09765 ENOG4106NMR serine protease HYQ63_RS09780 ENOG4105EAB amino acid AbC transporter HYQ63_RS09785 ENOG4105CDA abc transporter atp-binding protein HYQ63_RS09805 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HYQ63_RS09810 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS09815 ENOG4105C57 major facilitator superfamily HYQ63_RS09825 ENOG410841Q phosphoesterase PA-phosphatase related protein HYQ63_RS09840 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HYQ63_RS09855 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HYQ63_RS09865 ENOG4107ETC gas vesicle protein HYQ63_RS09870 ENOG4108XNA Gas vesicle HYQ63_RS09875 ENOG4105BZ9 Cytochrome C oxidase, subunit I HYQ63_RS09890 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HYQ63_RS09905 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HYQ63_RS09915 ENOG4105CAT Cytidine monophosphate kinase HYQ63_RS09930 ENOG4105FE9 pseudouridine synthase HYQ63_RS09935 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HYQ63_RS09940 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HYQ63_RS09955 ENOG4105DCF alanine dehydrogenase HYQ63_RS09960 ENOG4105F0K SARP family transcriptional regulator HYQ63_RS09965 ENOG4108YZ4 nudix hydrolase HYQ63_RS09970 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HYQ63_RS09975 ENOG4105BZP glycoside hydrolase 15-related HYQ63_RS09990 ENOG4107QPH glycogen) synthase HYQ63_RS09995 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HYQ63_RS10000 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HYQ63_RS10020 ENOG4105E0A ABC, transporter HYQ63_RS10025 ENOG4105TVJ transport system, permease HYQ63_RS10030 ENOG4105DQ5 transport system permease protein HYQ63_RS10035 ENOG4105DSU hydrolase HYQ63_RS10065 ENOG4108VX5 3-methyladenine DNA glycosylase HYQ63_RS10080 ENOG4108V1U phospholipid-binding protein HYQ63_RS10100 ENOG4105DKW ABC transporter HYQ63_RS10105 ENOG4108UF8 HYQ63_RS10115 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS10130 ENOG4105IDI abc transporter atp-binding protein HYQ63_RS10135 ENOG4105EAC phosphoserine phosphatase HYQ63_RS10150 ENOG4105DJ2 Major Facilitator Superfamily HYQ63_RS10155 ENOG4107YCY Transcriptional regulator HYQ63_RS10165 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HYQ63_RS10170 ENOG4105CHR reductase HYQ63_RS10185 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYQ63_RS10195 ENOG4105DJ2 Major Facilitator Superfamily HYQ63_RS10220 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HYQ63_RS10240 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HYQ63_RS10245 ENOG4107QN1 sodium solute HYQ63_RS10270 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HYQ63_RS10285 ENOG4105BZP glycoside hydrolase 15-related HYQ63_RS10290 ENOG4105CHR reductase HYQ63_RS10315 ENOG4105VBF alkaline shock protein HYQ63_RS10340 ENOG4105CHR reductase HYQ63_RS10345 ENOG4105GVJ transcriptional regulator HYQ63_RS10355 ENOG4105BZU Histidine kinase HYQ63_RS10375 ENOG41060WC Enoyl-CoA hydratase HYQ63_RS10385 ENOG4105C5H ABC transporter HYQ63_RS10400 ENOG4107W7X Aldolase HYQ63_RS10415 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HYQ63_RS10420 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HYQ63_RS10430 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HYQ63_RS10435 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HYQ63_RS10445 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HYQ63_RS10465 ENOG4105I6B RNA polymerase HYQ63_RS10475 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HYQ63_RS10485 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HYQ63_RS10490 ENOG4105EV8 ectoine hydroxylase HYQ63_RS10505 ENOG4107HP6 Transcriptional regulator HYQ63_RS10515 ENOG4105BZU Histidine kinase HYQ63_RS10520 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS10525 ENOG4105CPC Aldo Keto reductase HYQ63_RS10535 ENOG4108J20 pectate lyase HYQ63_RS10540 ENOG4107TDE lipolytic protein G-D-S-L family HYQ63_RS10555 ENOG4105E4I Glycoside hydrolase family 28 HYQ63_RS10590 ENOG4105DRR Transcriptional regulator, GntR family HYQ63_RS10625 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) HYQ63_RS10650 ENOG4105E9Z Nad-dependent epimerase dehydratase HYQ63_RS10660 ENOG4107TXC Transcriptional regulator HYQ63_RS10685 ENOG4105DTQ mandelate racemase muconate lactonizing HYQ63_RS10690 ENOG4108JQ1 Dehydrogenase HYQ63_RS10695 ENOG4106NZI LysR family Transcriptional regulator HYQ63_RS10710 ENOG4105C2C drug resistance transporter, Bcr CflA HYQ63_RS10715 ENOG4108ZT1 Transcriptional regulator HYQ63_RS10760 ENOG41080V3 Major Facilitator superfamily HYQ63_RS10765 ENOG4108VHT MarR family transcriptional regulator HYQ63_RS10790 ENOG4105C3M thioredoxin reductase HYQ63_RS10845 ENOG4105DEN Luciferase family HYQ63_RS10865 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYQ63_RS10870 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HYQ63_RS10875 ENOG4108RFG Tetr family transcriptional regulator HYQ63_RS10880 ENOG410814C multidrug resistance protein HYQ63_RS10885 ENOG4105VG1 fes assembly suf system protein HYQ63_RS10890 ENOG4108UNV SUF system FeS assembly protein, NifU family HYQ63_RS10895 ENOG4105C9B Cysteine desulfurase HYQ63_RS10900 ENOG4105C3K feS assembly ATPase SufC HYQ63_RS10910 ENOG4105JRK feS assembly protein SufD HYQ63_RS10935 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HYQ63_RS10950 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HYQ63_RS10955 ENOG4105CV1 Transketolase (EC 2.2.1.1) HYQ63_RS10960 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HYQ63_RS10975 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HYQ63_RS10980 ENOG4107QP8 phosphohexose isomerase HYQ63_RS10995 ENOG4105CP7 Triose-phosphate isomerase HYQ63_RS11000 ENOG4105BZA Phosphoglycerate kinase HYQ63_RS11005 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HYQ63_RS11015 ENOG4105CIE May be required for sporulation (By similarity) HYQ63_RS11025 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HYQ63_RS11030 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HYQ63_RS11050 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HYQ63_RS11055 ENOG4105C5X domain protein HYQ63_RS11075 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HYQ63_RS11080 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HYQ63_RS11085 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HYQ63_RS11135 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HYQ63_RS11145 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HYQ63_RS11155 ENOG4105CQ7 ATP-dependent helicase HYQ63_RS11170 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HYQ63_RS11195 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HYQ63_RS11205 ENOG4105C32 Amino acid ABC transporter (Permease) HYQ63_RS11210 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HYQ63_RS11215 ENOG4105C0Z ABC transporter HYQ63_RS11220 ENOG4108IV0 ABC, transporter HYQ63_RS11250 ENOG4105CGH 5'-nucleotidase HYQ63_RS11270 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HYQ63_RS11275 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HYQ63_RS11285 ENOG410905P Pyridoxamine 5-phosphate HYQ63_RS11295 ENOG4105CBC glutamate synthase HYQ63_RS11305 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HYQ63_RS11315 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HYQ63_RS11320 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HYQ63_RS11325 ENOG4105DK0 Indole-3-glycerol phosphate synthase HYQ63_RS11350 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HYQ63_RS11365 ENOG410814C multidrug resistance protein HYQ63_RS11375 ENOG41060NJ transcriptional regulator HYQ63_RS11380 ENOG4105CK5 oxidoreductase HYQ63_RS11395 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYQ63_RS11400 ENOG4105W1Y Transcriptional regulator HYQ63_RS11405 ENOG4105EMN RNA polymerase sigma factor HYQ63_RS11415 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HYQ63_RS11420 ENOG4108176 endoribonuclease L-psp HYQ63_RS11425 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HYQ63_RS11430 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HYQ63_RS11440 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HYQ63_RS11445 ENOG4105CIH Imidazole acetol-phosphate transaminase HYQ63_RS11450 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HYQ63_RS11460 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HYQ63_RS11465 ENOG4108Z66 YbaK ebsC protein HYQ63_RS11495 ENOG4105C0B DNA polymerase III (alpha subunit) HYQ63_RS11540 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HYQ63_RS11550 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HYQ63_RS11555 ENOG4107VQS DivIVA family HYQ63_RS11565 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HYQ63_RS11570 ENOG4105DFA alanine racemase domain protein HYQ63_RS11575 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HYQ63_RS11580 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HYQ63_RS11585 ENOG4105ME9 cell division protein FtsQ HYQ63_RS11590 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HYQ63_RS11600 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HYQ63_RS11605 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HYQ63_RS11615 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HYQ63_RS11620 ENOG4105CJN penicillin-binding protein HYQ63_RS11630 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HYQ63_RS11640 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HYQ63_RS11660 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HYQ63_RS11680 ENOG4107Z3H Transcriptional regulator, TetR family HYQ63_RS11685 ENOG4107VFM Dehydrogenase HYQ63_RS11700 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HYQ63_RS11710 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HYQ63_RS11725 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HYQ63_RS11755 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HYQ63_RS11770 ENOG4105PY6 Phenolic acid decarboxylase HYQ63_RS11780 ENOG4108UQY Iron-storage protein HYQ63_RS11790 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HYQ63_RS11830 ENOG4105C57 major facilitator superfamily HYQ63_RS11835 ENOG41064MX Tetr family transcriptional regulator HYQ63_RS11840 ENOG4105CTQ phosphohexokinase HYQ63_RS11845 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS11875 ENOG4105DKQ ROK family HYQ63_RS11885 ENOG4105D0U Arsenite-activated ATPase (ArsA) HYQ63_RS11920 ENOG4105K4H Nlp p60 protein HYQ63_RS11945 ENOG4105C9B Cysteine desulfurase HYQ63_RS11950 ENOG4108I0Q anthranilate phosphoribosyltransferase HYQ63_RS11955 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HYQ63_RS11960 ENOG4107EUI c reductase, iron-sulfur HYQ63_RS11965 ENOG4107UDY cytochrome C HYQ63_RS11970 ENOG4105CCU oxidase (Subunit III) HYQ63_RS11980 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HYQ63_RS11985 ENOG4105MCD Part of cytochrome c oxidase, its function is HYQ63_RS11990 ENOG4105BZ9 Cytochrome C oxidase, subunit I HYQ63_RS11995 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HYQ63_RS12000 ENOG4105C3J Cysteine desulfurase HYQ63_RS12005 ENOG4107T4Z adenosine kinase HYQ63_RS12025 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HYQ63_RS12030 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS12035 ENOG4105BZU Histidine kinase HYQ63_RS12070 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HYQ63_RS12075 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HYQ63_RS12080 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HYQ63_RS12100 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HYQ63_RS12110 ENOG4105CHR reductase HYQ63_RS12120 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HYQ63_RS12145 ENOG4108ZHR arsR family transcriptional regulator HYQ63_RS12155 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HYQ63_RS12160 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HYQ63_RS12210 ENOG4105BZU Histidine kinase HYQ63_RS12215 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS12230 ENOG4105F0N pyrophosphate phospho-hydrolase HYQ63_RS12255 ENOG4105CSH Transporter HYQ63_RS12275 ENOG4107NHD transcriptional regulator HYQ63_RS12290 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS12320 ENOG4105D56 permease protein HYQ63_RS12325 ENOG4107FKK extracellular solute-binding protein family 1 HYQ63_RS12330 ENOG4105CG3 alpha amylase, catalytic region HYQ63_RS12335 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS12345 ENOG4105DQF Hydrolase HYQ63_RS12350 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HYQ63_RS12395 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HYQ63_RS12400 ENOG4105SHT UspA domain-containing protein HYQ63_RS12405 ENOG4105C54 Major Facilitator superfamily HYQ63_RS12410 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HYQ63_RS12415 ENOG4105DDV Transcriptional regulator (LacI family HYQ63_RS12420 ENOG4105C5F glutamine synthetase HYQ63_RS12425 ENOG4107R16 Multicopper oxidase HYQ63_RS12430 ENOG4105C4K Nad synthetase HYQ63_RS12435 ENOG4105GRZ Ycii-related protein HYQ63_RS12440 ENOG4105CHP RNA polymerase HYQ63_RS12455 ENOG4108JA1 polyketide synthase HYQ63_RS12460 ENOG4105F27 Major Facilitator HYQ63_RS12470 ENOG4108JGH Tetr family transcriptional regulator HYQ63_RS12475 ENOG4105C57 major facilitator superfamily HYQ63_RS12480 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HYQ63_RS12500 ENOG4107XZ0 Peptidase M50 HYQ63_RS12530 ENOG4108478 ec 3.2.1.18 HYQ63_RS12570 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS12575 ENOG410650H (LipO)protein HYQ63_RS12580 ENOG4105DBE peroxidase HYQ63_RS12590 ENOG4106A0S HYQ63_RS12615 ENOG4107S1E Beta-lactamase HYQ63_RS12620 ENOG4105C2C drug resistance transporter, Bcr CflA HYQ63_RS12630 ENOG4105DGI Alkaline phosphatase HYQ63_RS12635 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HYQ63_RS12655 ENOG4106NZI LysR family Transcriptional regulator HYQ63_RS12670 ENOG4105D29 Helix-turn-helix type 11 domain protein HYQ63_RS12690 ENOG4105DND Transcriptional regulator HYQ63_RS12790 ENOG4108KQ5 Integrase catalytic subunit HYQ63_RS12810 ENOG4105CG3 alpha amylase, catalytic region HYQ63_RS12815 ENOG4107XFJ UPF0246 protein HYQ63_RS12820 ENOG4108UHU Aldolase HYQ63_RS12835 ENOG4105EGD dinuclear metal center protein, YbgI family HYQ63_RS12840 ENOG4108MES Periplasmic binding protein HYQ63_RS12855 ENOG4105CHR reductase HYQ63_RS12885 ENOG4105D2B acyl-CoA dehydrogenase HYQ63_RS12895 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase HYQ63_RS12905 ENOG4105DYW oxidoreductase HYQ63_RS12920 ENOG4107QVI Methyltransferase, type 11 HYQ63_RS12925 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HYQ63_RS12930 ENOG4108SGK Tetr family transcriptional regulator HYQ63_RS12990 ENOG4105BZ1 (ABC) transporter HYQ63_RS13025 ENOG4105F2C Acetyl-CoA acetyltransferase HYQ63_RS13030 ENOG4106A3M Cytochrome p-450 HYQ63_RS13055 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HYQ63_RS13070 ENOG4105CYW agmatinase HYQ63_RS13080 ENOG4105BZU Histidine kinase HYQ63_RS13200 ENOG4105E4C Lytic transglycosylase catalytic HYQ63_RS13255 ENOG4105MSB protein, conserved in bacteria HYQ63_RS13275 ENOG4105E82 cytochrome subunit of dehydrogenase HYQ63_RS13315 ENOG4105BZU Histidine kinase HYQ63_RS13320 ENOG4107T5V SNARE associated Golgi HYQ63_RS13330 ENOG4105DAX Pfam:DUF2983 HYQ63_RS13405 ENOG4108ZGX Histidine kinase HYQ63_RS13410 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS13430 ENOG4105VUF Transcriptional regulator HYQ63_RS13445 ENOG4105DJB Major Facilitator Superfamily HYQ63_RS13450 ENOG4105DIA mandelate racemase muconate lactonizing HYQ63_RS13455 ENOG4105CPQ Dehydrogenase HYQ63_RS13460 ENOG4105CHR reductase HYQ63_RS13480 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HYQ63_RS13485 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HYQ63_RS13510 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HYQ63_RS13515 ENOG4108R86 Transcriptional regulator HYQ63_RS13545 ENOG4105CXK mandelate racemase muconate lactonizing HYQ63_RS13565 ENOG4105C2J ABC transporter HYQ63_RS13570 ENOG4108HWW ABC transporter HYQ63_RS13575 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HYQ63_RS13595 ENOG4105DBA pectate lyase HYQ63_RS13615 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HYQ63_RS13620 ENOG4108MYR Secreted protein HYQ63_RS13625 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HYQ63_RS13630 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HYQ63_RS13645 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HYQ63_RS13650 ENOG4107HP6 Transcriptional regulator HYQ63_RS13675 ENOG4108M6P methyltransferase HYQ63_RS13680 ENOG41073B4 coagulation factor 5 8 type domain-containing protein HYQ63_RS13715 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HYQ63_RS13720 ENOG41080RH Thioredoxin HYQ63_RS13740 ENOG4105CNA YD repeat protein HYQ63_RS13750 ENOG4105EMU Dehydrogenase HYQ63_RS13775 ENOG4105C22 threonyL-tRNA synthetase HYQ63_RS13800 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HYQ63_RS13805 ENOG4105DU0 nucleoside hydrolase HYQ63_RS13810 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid HYQ63_RS13870 ENOG4105C57 major facilitator superfamily HYQ63_RS13885 ENOG4108HKT sucrose-6-phosphate hydrolase HYQ63_RS13895 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HYQ63_RS13900 ENOG4105DRS transport system, permease HYQ63_RS13920 ENOG4107XZQ multidrug resistance protein HYQ63_RS13945 ENOG4105JAB phenazine biosynthesis protein, phzf family HYQ63_RS13965 ENOG4106SDP Involved in the biosynthesis of the antibiotic, phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control HYQ63_RS13975 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HYQ63_RS13995 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HYQ63_RS14045 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYQ63_RS14050 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HYQ63_RS14060 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HYQ63_RS14085 ENOG4108UB4 uncharacterized protein ygjQ HYQ63_RS14175 ENOG4106A3M Cytochrome p-450 HYQ63_RS14180 ENOG4107QZF nitrite reductase NADPH large subunit HYQ63_RS14190 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HYQ63_RS14195 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS14205 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HYQ63_RS14230 ENOG4105JNK Glycosyl transferase (Group 1 HYQ63_RS14240 ENOG4105BZU Histidine kinase HYQ63_RS14245 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS14270 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HYQ63_RS14280 ENOG4105DJB Major Facilitator Superfamily HYQ63_RS14285 ENOG4105CPQ Dehydrogenase HYQ63_RS14290 ENOG4107258 Transcriptional regulator HYQ63_RS14295 ENOG41067TZ transcriptional regulator, MarR family HYQ63_RS14310 ENOG4105CHU acetyl-coa acetyltransferase HYQ63_RS14320 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HYQ63_RS14325 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HYQ63_RS14330 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HYQ63_RS14355 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HYQ63_RS14385 ENOG4108FN7 Aldo keto reductase HYQ63_RS14400 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HYQ63_RS14410 ENOG4105FDK ABC transporter HYQ63_RS14425 ENOG4108UYE Lactoylglutathione lyase HYQ63_RS14480 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HYQ63_RS14485 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HYQ63_RS14535 ENOG4106178 UPF0339 protein HYQ63_RS14560 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HYQ63_RS14565 ENOG4105D4Y metalloprotease HYQ63_RS14575 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HYQ63_RS14595 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HYQ63_RS14605 ENOG4107T4Z adenosine kinase HYQ63_RS14610 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HYQ63_RS14615 ENOG4107YU2 histidine triad (hIT) protein HYQ63_RS14625 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HYQ63_RS14640 ENOG4107QWG 2-Nitropropane dioxygenase HYQ63_RS14645 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HYQ63_RS14650 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HYQ63_RS14675 ENOG4108IQE Amp-dependent synthetase and ligase HYQ63_RS14680 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HYQ63_RS14685 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HYQ63_RS14715 ENOG4105C0D helicase HYQ63_RS14740 ENOG4108KQ5 Integrase catalytic subunit HYQ63_RS14785 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HYQ63_RS14790 ENOG4105EPR degv family HYQ63_RS14800 ENOG4105C8T Leucyl-tRNA synthetase HYQ63_RS14825 ENOG4108ZM9 phosphoglycerate mutase HYQ63_RS14840 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HYQ63_RS14855 ENOG4105D0M Protease HtpX homolog HYQ63_RS14870 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HYQ63_RS14880 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HYQ63_RS14890 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HYQ63_RS14895 ENOG4105K46 50S ribosomal protein l27 HYQ63_RS14900 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HYQ63_RS14905 ENOG4105C03 ribonuclease HYQ63_RS14925 ENOG4105CNI cell division protein FtsW HYQ63_RS14930 ENOG4105CJN penicillin-binding protein HYQ63_RS14945 ENOG4105DFF Rod shape-determining protein mreb HYQ63_RS14950 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HYQ63_RS14960 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HYQ63_RS14965 ENOG4105CJN penicillin-binding protein HYQ63_RS14990 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HYQ63_RS14995 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HYQ63_RS15000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HYQ63_RS15005 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HYQ63_RS15025 ENOG4108TGC Acyltransferase HYQ63_RS15050 ENOG4105C85 amino acid HYQ63_RS15060 ENOG4105C85 amino acid HYQ63_RS15065 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HYQ63_RS15070 ENOG4105MC2 DSBA oxidoreductase HYQ63_RS15150 ENOG4105D8X mechanosensitive ion channel HYQ63_RS15155 ENOG4105E2R ROK family HYQ63_RS15165 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HYQ63_RS15170 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HYQ63_RS15175 ENOG4105F8D glycoside hydrolase family 4 HYQ63_RS15190 ENOG4105CT1 (ABC) transporter HYQ63_RS15220 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HYQ63_RS15250 ENOG4105VHU single-stranded DNA-binding protein HYQ63_RS15255 ENOG4105EM7 Selenocysteine-specific translation elongation factor HYQ63_RS15310 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HYQ63_RS15315 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HYQ63_RS15330 ENOG4105ZXU NLP P60 protein HYQ63_RS15455 ENOG4105CVR type I restriction-modification system HYQ63_RS15470 ENOG4108ZT1 Transcriptional regulator HYQ63_RS15480 ENOG4105WBD 4-oxalocrotonate tautomerase HYQ63_RS15520 ENOG4105WQT MbtH domain protein HYQ63_RS15530 ENOG4105KJJ Uncharacterized ACR, COG1993 HYQ63_RS15535 ENOG41083TI Protein CrcB homolog HYQ63_RS15540 ENOG4106NZI LysR family Transcriptional regulator HYQ63_RS15555 ENOG4105E33 succinate dehydrogenase HYQ63_RS15610 ENOG4107EEY synthase HYQ63_RS15650 ENOG410905X membrane-flanked domain protein HYQ63_RS15660 ENOG4105BZU Histidine kinase HYQ63_RS15665 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS15690 ENOG4105C26 Dehydrogenase HYQ63_RS15695 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HYQ63_RS15700 ENOG4105DH8 myo-inositol catabolism HYQ63_RS15710 ENOG4105EDK PfkB domain protein HYQ63_RS15725 ENOG4105C2J ABC transporter HYQ63_RS15735 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HYQ63_RS15740 ENOG4105F0H myo-inositol catabolism protein HYQ63_RS15750 ENOG4107R13 MMPL domain protein HYQ63_RS15775 ENOG4105C7H Helicase, RecD TraA family HYQ63_RS15780 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS15785 ENOG4105C2J ABC transporter HYQ63_RS15790 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HYQ63_RS15795 ENOG4108RVA ribokinase HYQ63_RS15800 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HYQ63_RS15805 ENOG4107QJZ Glycosyl transferase, family 2 HYQ63_RS15810 ENOG4108KGH TRANSCRIPTIONal HYQ63_RS15860 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HYQ63_RS15865 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HYQ63_RS15890 ENOG41060NJ transcriptional regulator HYQ63_RS15940 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HYQ63_RS15965 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HYQ63_RS15990 ENOG4105D17 glycoside hydrolase, family 3 domain protein HYQ63_RS16030 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS16035 ENOG4105BZU Histidine kinase HYQ63_RS16065 ENOG4105VEQ Cold shock protein HYQ63_RS16070 ENOG4105C1J atp-dependent rna helicase HYQ63_RS16075 ENOG4108XFF HYQ63_RS16080 ENOG4105C29 acyl-CoA thioesterase HYQ63_RS16095 ENOG4107QX3 carboxylase HYQ63_RS16105 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HYQ63_RS16110 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS16120 ENOG4105E2D ec 3.2.1.52 HYQ63_RS16135 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HYQ63_RS16150 ENOG4105ECQ AraC Family Transcriptional Regulator HYQ63_RS16155 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HYQ63_RS16180 ENOG4105CHR reductase HYQ63_RS16200 ENOG4105CEP NADH dehydrogenase HYQ63_RS16205 ENOG4108KPJ rna polymerase sigma factor HYQ63_RS16240 ENOG4105CYP glycoside hydrolase, family HYQ63_RS16245 ENOG41065HY 1,4-beta-cellobiosidase HYQ63_RS16250 ENOG41065HY 1,4-beta-cellobiosidase HYQ63_RS16255 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS16280 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HYQ63_RS16285 ENOG4108NNZ chitinase HYQ63_RS16305 ENOG4105CVJ phosphoglycerate mutase HYQ63_RS16350 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HYQ63_RS16385 ENOG4105BZU Histidine kinase HYQ63_RS16405 ENOG4105BZU Histidine kinase HYQ63_RS16410 ENOG4105DEN Luciferase family HYQ63_RS16425 ENOG4105C5I Dehydrogenase HYQ63_RS16430 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HYQ63_RS16480 ENOG4108JGH Tetr family transcriptional regulator HYQ63_RS16485 ENOG4108MUZ hydrolase HYQ63_RS16500 ENOG4108JIK carboxylase HYQ63_RS16520 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HYQ63_RS16525 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HYQ63_RS16535 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HYQ63_RS16560 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HYQ63_RS16585 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HYQ63_RS16590 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HYQ63_RS16605 ENOG4105C57 major facilitator superfamily HYQ63_RS16610 ENOG4105CPQ Dehydrogenase HYQ63_RS16625 ENOG4107XKF NMT1 THI5 Like Domain Protein HYQ63_RS16630 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component HYQ63_RS16665 ENOG4108M1A Chitin-binding protein HYQ63_RS16685 ENOG4105D9U N-acetyltransferase HYQ63_RS16745 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HYQ63_RS16750 ENOG4108IND Tetr family transcriptional regulator HYQ63_RS16770 ENOG4105JXH GntR family transcriptional regulator HYQ63_RS16785 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HYQ63_RS16830 ENOG4105D9R oxidoreductase HYQ63_RS16835 ENOG41090KN UPF0303 protein HYQ63_RS16860 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HYQ63_RS16870 ENOG4108U4N (sortase) family HYQ63_RS16875 ENOG4106BRA Membrane HYQ63_RS16905 ENOG4105BZ4 penicillin-binding protein HYQ63_RS16910 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HYQ63_RS16930 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HYQ63_RS16940 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HYQ63_RS16955 ENOG4108RQ5 Beta-lactamase domain-containing protein HYQ63_RS16975 ENOG4105C85 amino acid HYQ63_RS16985 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HYQ63_RS16995 ENOG4108RWI nicotinamidase HYQ63_RS17030 ENOG4105CQB FAD linked oxidase domain protein HYQ63_RS17040 ENOG4105EMN RNA polymerase sigma factor HYQ63_RS17055 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HYQ63_RS17080 ENOG41086VY Fic/DOC family HYQ63_RS17095 ENOG4107ZR7 Membrane HYQ63_RS17105 ENOG4105DND Transcriptional regulator HYQ63_RS17120 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS17130 ENOG4108W6C Dehydrogenase HYQ63_RS17170 ENOG4105E2D ec 3.2.1.52 HYQ63_RS17200 ENOG4108RWP Major Facilitator Superfamily protein HYQ63_RS17210 ENOG4108UJU UPF0301 protein HYQ63_RS17215 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HYQ63_RS17220 ENOG4108426 dNA-binding protein HYQ63_RS17230 ENOG4105VEQ Cold shock protein HYQ63_RS17235 ENOG4105EEM helicase HYQ63_RS17260 ENOG4105DQQ Major facilitator superfamily MFS_1 HYQ63_RS17290 ENOG4105CJQ hydrolase, family 31 HYQ63_RS17295 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HYQ63_RS17335 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HYQ63_RS17340 ENOG4105CN1 protease HYQ63_RS17345 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HYQ63_RS17350 ENOG4105CAK Cell division ATP-binding protein ftsE HYQ63_RS17365 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HYQ63_RS17370 ENOG4108QVN serine threonine protein kinase HYQ63_RS17375 ENOG4108UGD Serine Threonine protein kinase HYQ63_RS17385 ENOG4105EPJ extracellular solute-binding protein family 1 HYQ63_RS17390 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HYQ63_RS17395 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HYQ63_RS17440 ENOG4107SJB teichoic acid biosynthesis HYQ63_RS17450 ENOG4105C7I Dehydrogenase HYQ63_RS17475 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HYQ63_RS17485 ENOG4105T0Z Conserved Protein HYQ63_RS17490 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS17495 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HYQ63_RS17505 ENOG4105G3P Lipoprotein lpqB HYQ63_RS17510 ENOG4105BZU Histidine kinase HYQ63_RS17515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYQ63_RS17520 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HYQ63_RS17550 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HYQ63_RS17555 ENOG4105DM4 PTS System HYQ63_RS17565 ENOG4105EIP mannose-6-phosphate isomerase HYQ63_RS17575 ENOG4105W49 UPF0434 protein HYQ63_RS17580 ENOG4107QKV phosphomannomutase HYQ63_RS17585 ENOG4105DAA L-lactate HYQ63_RS17605 ENOG4107RGC Glycosyl transferase, family 2 HYQ63_RS17610 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HYQ63_RS17625 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HYQ63_RS17635 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HYQ63_RS17655 ENOG4107TB5 TRANSCRIPTIONal HYQ63_RS17675 ENOG4108KGH TRANSCRIPTIONal HYQ63_RS17705 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HYQ63_RS17710 ENOG4108S4H thioesterase Superfamily protein HYQ63_RS17715 ENOG4108KGH TRANSCRIPTIONal HYQ63_RS17740 ENOG4105HSS phospholipase C HYQ63_RS17750 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HYQ63_RS17770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYQ63_RS17775 ENOG4105DUX Transporter HYQ63_RS17780 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HYQ63_RS17815 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYQ63_RS17820 ENOG4105CI2 imidazolone-5-propionate hydrolase HYQ63_RS17835 ENOG4105CGP Urocanate hydratase HYQ63_RS17840 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HYQ63_RS17855 ENOG4105C84 Histidine ammonia-lyase HYQ63_RS17860 ENOG4108IJ8 ABC transporter HYQ63_RS17865 ENOG4105E90 ABC transporter HYQ63_RS17870 ENOG4105E90 ABC transporter HYQ63_RS17880 ENOG4105ETS cytosine purines uracil thiamine allantoin HYQ63_RS17900 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS17920 ENOG4105CHU acetyl-coa acetyltransferase HYQ63_RS17950 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HYQ63_RS17955 ENOG4107RBB ABC transporter, permease HYQ63_RS17960 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HYQ63_RS17965 ENOG4105CEP NADH dehydrogenase HYQ63_RS17985 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HYQ63_RS17995 ENOG4106839 domain protein HYQ63_RS18000 ENOG4106A3M Cytochrome p-450 HYQ63_RS18030 ENOG4106A3M Cytochrome p-450 HYQ63_RS18035 ENOG4108VUG Enoyl-CoA hydratase HYQ63_RS18080 ENOG4105C84 Histidine ammonia-lyase HYQ63_RS18085 ENOG4105KDM Diguanylate cyclase with gaf sensor HYQ63_RS18090 ENOG4105E39 Enoyl-CoA hydratase HYQ63_RS18095 ENOG4106A3M Cytochrome p-450 HYQ63_RS18100 ENOG4108QER Adenylate cyclase HYQ63_RS18110 ENOG4105D8K carboxyl transferase HYQ63_RS18120 ENOG4107WR6 Maf-like protein HYQ63_RS18130 ENOG4108JIK carboxylase HYQ63_RS18170 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HYQ63_RS18185 ENOG4105C26 Dehydrogenase HYQ63_RS18190 ENOG4105C26 Dehydrogenase HYQ63_RS18235 ENOG4105NPE arsR family transcriptional regulator HYQ63_RS18260 ENOG4105NAF rna polymerase sigma factor HYQ63_RS18265 ENOG4108KXV response regulator HYQ63_RS18270 ENOG41065SU Two-component system sensor kinase HYQ63_RS18295 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HYQ63_RS18305 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HYQ63_RS18315 ENOG4108Z6Z Transcriptional regulator HYQ63_RS18330 ENOG4105DHH glycosyltransferase MGT family HYQ63_RS18335 ENOG4105C6Y Udp-glucose 6-dehydrogenase HYQ63_RS18345 ENOG4107RSM transcriptional regulator HYQ63_RS18350 ENOG4105D94 Major Facilitator Superfamily HYQ63_RS18400 ENOG4105UIB (ABC) transporter HYQ63_RS18405 ENOG4108JQ9 ABC transporter HYQ63_RS18410 ENOG4105DIH basic membrane HYQ63_RS18415 ENOG4107RM1 amidohydrolase HYQ63_RS18425 ENOG4105D2T synthase HYQ63_RS18430 ENOG4105F0R Cytidylyltransferase HYQ63_RS18440 ENOG4105K64 Glycosyl transferase, family 2 HYQ63_RS18510 ENOG410904N short-chain dehydrogenase reductase HYQ63_RS18530 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F HYQ63_RS18550 ENOG4105CPQ Dehydrogenase HYQ63_RS18555 ENOG4105CHR reductase HYQ63_RS18560 ENOG4105C6Z Gluconate HYQ63_RS18565 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HYQ63_RS18570 ENOG4105C6F GntR Family Transcriptional Regulator HYQ63_RS18585 ENOG4105CPC Aldo Keto reductase HYQ63_RS18595 ENOG4107S5I aldo keto reductase HYQ63_RS18660 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HYQ63_RS18680 ENOG4105C0B DNA polymerase III (alpha subunit) HYQ63_RS18685 ENOG4105EBM Alpha Beta Hydrolase Fold protein HYQ63_RS18730 ENOG4108MMM RNA Polymerase HYQ63_RS18740 ENOG4105E2D ec 3.2.1.52 HYQ63_RS18760 ENOG4108J01 L-aspartate oxidase HYQ63_RS18770 ENOG4107QPV Serine Threonine protein kinase HYQ63_RS18775 ENOG4107RN3 metallophosphoesterase HYQ63_RS18785 ENOG4107H3J ribonuclease HYQ63_RS18795 ENOG4105C31 Tryptophanyl-tRNA synthetase HYQ63_RS18800 ENOG4105EMN RNA polymerase sigma factor HYQ63_RS18805 ENOG4105C8Y Acetylornithine aminotransferase HYQ63_RS18810 ENOG4106032 Glutathionylspermidine synthase HYQ63_RS18820 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYQ63_RS18825 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HYQ63_RS18830 ENOG4105CR4 methylisocitrate lyase HYQ63_RS18840 ENOG4108HQS Glycine betaine HYQ63_RS18845 ENOG4108IJ7 Glycine betaine HYQ63_RS18880 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HYQ63_RS18895 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HYQ63_RS18900 ENOG4105DC1 bifunctional purine biosynthesis protein purh HYQ63_RS18925 ENOG4105CMV Succinyl-CoA synthetase subunit beta HYQ63_RS18940 ENOG4105DEG Vwa containing coxe family protein HYQ63_RS18950 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HYQ63_RS18975 ENOG4105DR5 peptidase HYQ63_RS19020 ENOG4107TXC Transcriptional regulator HYQ63_RS19025 ENOG4108Z6Z Transcriptional regulator HYQ63_RS19030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYQ63_RS19070 ENOG4105D3W isochorismatase HYQ63_RS19155 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS19180 ENOG4105D9P serine threonine protein kinase HYQ63_RS19205 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HYQ63_RS19225 ENOG4105C26 Dehydrogenase HYQ63_RS19230 ENOG4105D9P serine threonine protein kinase HYQ63_RS19235 ENOG4105D9P serine threonine protein kinase HYQ63_RS19255 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS19260 ENOG4105ENE Histidine kinase HYQ63_RS19265 ENOG41082AN stage II sporulation protein HYQ63_RS19310 ENOG4105CJ1 ABC, transporter HYQ63_RS19330 ENOG4108XEP Alpha Beta Hydrolase Fold protein HYQ63_RS19340 ENOG4108SU4 UPF0309 protein HYQ63_RS19350 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HYQ63_RS19370 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS19385 ENOG4107QX3 carboxylase HYQ63_RS19405 ENOG4105CQB FAD linked oxidase domain protein HYQ63_RS19410 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HYQ63_RS19425 ENOG4105CPC Aldo Keto reductase HYQ63_RS19445 ENOG4105C7N Xanthine uracil vitamin C permease HYQ63_RS19475 ENOG4108N0W Major Facilitator superfamily HYQ63_RS19485 ENOG4108UIH futalosine nucleosidase HYQ63_RS19490 ENOG4105E63 Pfam:DUF178 HYQ63_RS19495 ENOG4105VEQ Cold shock protein HYQ63_RS19510 ENOG4105DQ5 transport system permease protein HYQ63_RS19515 ENOG4105TVJ transport system, permease HYQ63_RS19520 ENOG4105E0A ABC, transporter HYQ63_RS19525 ENOG4108KQ5 Integrase catalytic subunit HYQ63_RS19555 ENOG4105EEM helicase HYQ63_RS19610 ENOG4105F27 Major Facilitator HYQ63_RS19630 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HYQ63_RS19635 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HYQ63_RS19640 ENOG4105VEQ Cold shock protein HYQ63_RS19655 ENOG4105C3Q Glycosyl transferase, family 2 HYQ63_RS19660 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HYQ63_RS19680 ENOG4105DKQ ROK family HYQ63_RS19685 ENOG4105CE4 GlcNAc 6-P deacetylase HYQ63_RS19700 ENOG4105BZU Histidine kinase HYQ63_RS19710 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HYQ63_RS19760 ENOG4105EXC Acyl-transferase HYQ63_RS19820 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HYQ63_RS19830 ENOG4105C2N RNA methyltransferase TrmH family group 3 HYQ63_RS19835 ENOG4105C8N cysteinyl-tRNA synthetase HYQ63_RS19845 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HYQ63_RS19850 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HYQ63_RS19855 ENOG4108VJ1 Transcriptional regulator (CarD family HYQ63_RS19870 ENOG4105BZU Histidine kinase HYQ63_RS19885 ENOG4108SHN Glycosyl transferase, family 2 HYQ63_RS19910 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HYQ63_RS19920 ENOG4105DDI hemolysin-type calcium-binding region HYQ63_RS19925 ENOG4108YZJ Pfam:DUF2596 HYQ63_RS19930 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HYQ63_RS19945 ENOG4105CPC Aldo Keto reductase HYQ63_RS19965 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HYQ63_RS19970 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HYQ63_RS19975 ENOG4105CGH 5'-nucleotidase HYQ63_RS20020 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HYQ63_RS20030 ENOG4108IYU L-aspartate oxidase HYQ63_RS20035 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HYQ63_RS20055 ENOG41082SX arsR family transcriptional regulator HYQ63_RS20060 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS20080 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS20095 ENOG4105E90 ABC transporter HYQ63_RS20100 ENOG4105E90 ABC transporter HYQ63_RS20105 ENOG4108IJ8 ABC transporter HYQ63_RS20115 ENOG4105CRK lysyL-tRNA synthetase HYQ63_RS20135 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HYQ63_RS20145 ENOG4105EUJ GTP cyclohydrolase i HYQ63_RS20155 ENOG4108UGV hypoxanthine phosphoribosyltransferase HYQ63_RS20160 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HYQ63_RS20175 ENOG4105F0N pyrophosphate phospho-hydrolase HYQ63_RS20185 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HYQ63_RS20190 ENOG4107TXC Transcriptional regulator HYQ63_RS20195 ENOG4108NIW Leucine export protein LeuE HYQ63_RS20200 ENOG4105CVK Glutamate decarboxylase HYQ63_RS20230 ENOG4105C26 Dehydrogenase HYQ63_RS20255 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HYQ63_RS20260 ENOG4105C2M dna polymerase I HYQ63_RS20280 ENOG4105EMN RNA polymerase sigma factor HYQ63_RS20290 ENOG4106R7G Glycoside hydrolase family 5 HYQ63_RS20295 ENOG4107QQR Sporulation HYQ63_RS20300 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HYQ63_RS20305 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HYQ63_RS20335 ENOG4105ENE Histidine kinase HYQ63_RS20340 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS20345 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS20350 ENOG4105ENE Histidine kinase HYQ63_RS20385 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYQ63_RS20405 ENOG4105C6E dna polymerase iii HYQ63_RS20410 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HYQ63_RS20415 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HYQ63_RS20425 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HYQ63_RS20435 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HYQ63_RS20440 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HYQ63_RS20445 ENOG4105WN5 stage II sporulation protein HYQ63_RS20450 ENOG4108I5C dEAD DEAH box helicase HYQ63_RS20505 ENOG4107B2H carbonic anhydrase HYQ63_RS20510 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HYQ63_RS20515 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HYQ63_RS20535 ENOG4105P8F nudix hydrolase HYQ63_RS20550 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HYQ63_RS20585 ENOG4105BZ4 penicillin-binding protein HYQ63_RS20610 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HYQ63_RS20615 ENOG410834F Transcriptional regulator HYQ63_RS20695 ENOG4105CFH Aspartokinase HYQ63_RS20705 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HYQ63_RS20710 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HYQ63_RS20750 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HYQ63_RS20765 ENOG4108JGH Tetr family transcriptional regulator HYQ63_RS20770 ENOG4105D7N magnesium and cobalt transport protein CorA HYQ63_RS20775 ENOG4105NAE bifunctional deaminase-reductase domain protein HYQ63_RS20785 ENOG4106A3M Cytochrome p-450 HYQ63_RS20840 ENOG4105JSC dimethylmenaquinone methyltransferase HYQ63_RS20855 ENOG4105CSH Transporter HYQ63_RS20860 ENOG4107R7A Allophanate hydrolase subunit 2 HYQ63_RS20865 ENOG4105P4J Allophanate hydrolase, subunit 1 HYQ63_RS20905 ENOG4105DV0 amidase (EC 3.5.1.4 HYQ63_RS20910 ENOG4105E1V na solute symporter HYQ63_RS20920 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HYQ63_RS20925 ENOG4108TGC Acyltransferase HYQ63_RS20935 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HYQ63_RS20945 ENOG4105CGD Nad-dependent epimerase dehydratase HYQ63_RS20960 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HYQ63_RS20975 ENOG4108Z6B deaminase HYQ63_RS20985 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HYQ63_RS21040 ENOG4105CTQ phosphohexokinase HYQ63_RS21050 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYQ63_RS21055 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYQ63_RS21070 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HYQ63_RS21080 ENOG4108YYC ycei family HYQ63_RS21090 ENOG4105C57 major facilitator superfamily HYQ63_RS21095 ENOG4105EDW glycosyl transferase, family 39 HYQ63_RS21105 ENOG4105BZU Histidine kinase HYQ63_RS21110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYQ63_RS21185 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS21190 ENOG4105NAF rna polymerase sigma factor HYQ63_RS21210 ENOG4108KC2 acyl-Coa dehydrogenase HYQ63_RS21220 ENOG4105X7H acyl-CoA dehydrogenase HYQ63_RS21255 ENOG41082YX Transcriptional regulator, arsr family HYQ63_RS21280 ENOG4105VZ8 Transcriptional regulator HYQ63_RS21300 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HYQ63_RS21360 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HYQ63_RS21390 ENOG4105C0H protease HYQ63_RS21405 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HYQ63_RS21420 ENOG4107T6F Xaa-Pro aminopeptidase HYQ63_RS21460 ENOG4105DBE peroxidase HYQ63_RS21465 ENOG4105CQC Prephenate dehydratase HYQ63_RS21470 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HYQ63_RS21475 ENOG410667J hydrolase HYQ63_RS21500 ENOG4105DJ2 Major Facilitator Superfamily HYQ63_RS21525 ENOG4105DA5 (ABC) transporter HYQ63_RS21545 ENOG4105D0M Protease HtpX homolog HYQ63_RS21555 ENOG4108K4B hydrolase HYQ63_RS21570 ENOG4108JJ9 ABC, transporter HYQ63_RS21575 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HYQ63_RS21580 ENOG4105C4M (Ubiquinol oxidase) subunit I HYQ63_RS21585 ENOG4105CIH Imidazole acetol-phosphate transaminase HYQ63_RS21590 ENOG4107P2S Transcriptional regulator HYQ63_RS21610 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HYQ63_RS21620 ENOG4105KF0 sporulation and cell division protein, SsgA HYQ63_RS21630 ENOG4106048 Cupin 2, conserved barrel domain protein HYQ63_RS21635 ENOG41082T9 Membrane HYQ63_RS21640 ENOG4105KJF protein tyrosine phosphatase HYQ63_RS21645 ENOG4105C28 cystathionine HYQ63_RS21700 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HYQ63_RS21705 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HYQ63_RS21715 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HYQ63_RS21720 ENOG4105CDU Replicative dna helicase HYQ63_RS21725 ENOG4107QI1 Mate efflux family protein HYQ63_RS21730 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HYQ63_RS21735 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HYQ63_RS21740 ENOG4107YH6 single-stranded DNA-binding protein HYQ63_RS21745 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HYQ63_RS21770 ENOG4105BZ4 penicillin-binding protein HYQ63_RS21790 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HYQ63_RS21805 ENOG4105D9P serine threonine protein kinase HYQ63_RS21820 ENOG4105C3M thioredoxin reductase HYQ63_RS21825 ENOG4105K63 Thioredoxin HYQ63_RS21840 ENOG4107QJE Chromosome Partitioning Protein HYQ63_RS21845 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HYQ63_RS21855 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HYQ63_RS21860 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HYQ63_RS21865 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HYQ63_RS21870 ENOG41084CH 50S ribosomal protein l34 HYQ63_RS21880 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HYQ63_RS21885 ENOG4108J5G 6-phosphogluconate dehydrogenase HYQ63_RS21890 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HYQ63_RS21895 ENOG4105K7N UPF0232 protein HYQ63_RS21900 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYQ63_RS21905 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYQ63_RS21930 ENOG4108UGD Serine Threonine protein kinase HYQ63_RS21945 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HYQ63_RS21965 ENOG4105ZJT Cell division protein CrgA HYQ63_RS21975 ENOG4108U4N (sortase) family HYQ63_RS21990 ENOG4108U4N (sortase) family HYQ63_RS21995 ENOG4108RN7 integral membrane protein HYQ63_RS22005 ENOG4105CJN penicillin-binding protein HYQ63_RS22020 ENOG4105HZM Fha domain containing protein HYQ63_RS22025 ENOG4105TV9 FHA Domain-Containing protein HYQ63_RS22035 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HYQ63_RS22040 ENOG4105KVH Transcriptional regulator HYQ63_RS22055 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HYQ63_RS22065 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HYQ63_RS22070 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HYQ63_RS22075 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HYQ63_RS22080 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HYQ63_RS22085 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HYQ63_RS22100 ENOG4108KPJ rna polymerase sigma factor HYQ63_RS22105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYQ63_RS22120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HYQ63_RS22125 ENOG4108IG5 Transcriptional regulator HYQ63_RS22145 ENOG4107QSN dihydrolipoamide acetyltransferase HYQ63_RS22155 ENOG4105CVM Molybdenum cofactor synthesis domain protein HYQ63_RS22160 ENOG4107SVH Potassium channel protein HYQ63_RS22175 ENOG4108VC7 Protein of unknown function (DUF2587) HYQ63_RS22180 ENOG4105C1B dTDP-glucose 4-6-dehydratase HYQ63_RS22185 ENOG4107QPV Serine Threonine protein kinase HYQ63_RS22210 ENOG4105CPP Dehydrogenase, E1 component HYQ63_RS22215 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HYQ63_RS22255 ENOG4105F0K SARP family transcriptional regulator HYQ63_RS22260 ENOG4105DFM M18 family aminopeptidase HYQ63_RS22275 ENOG4105CSU acyl-Coa dehydrogenase HYQ63_RS22285 ENOG4105EUB pirin domain protein HYQ63_RS22295 ENOG4105C9M aspartyl-trna synthetase HYQ63_RS22315 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HYQ63_RS22330 ENOG4105DQE DNA ligase HYQ63_RS22345 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HYQ63_RS22355 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HYQ63_RS22415 ENOG41082SX arsR family transcriptional regulator HYQ63_RS22440 ENOG4105CAQ asparagine synthetase HYQ63_RS22445 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HYQ63_RS22455 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HYQ63_RS22475 ENOG4105CB2 alcohol dehydrogenase HYQ63_RS22485 ENOG4107V2S Transcriptional regulator HYQ63_RS22530 ENOG4105NRA 50s ribosomal protein l31 type b HYQ63_RS22540 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HYQ63_RS22545 ENOG4108762 serine threonine protein kinase HYQ63_RS22575 ENOG4108N23 SpoOM-related protein HYQ63_RS22595 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYQ63_RS22600 ENOG4105DY8 decarboxylase HYQ63_RS22625 ENOG4108Z6Z Transcriptional regulator HYQ63_RS22640 ENOG4105NAE bifunctional deaminase-reductase domain protein HYQ63_RS22680 ENOG4105C1J atp-dependent rna helicase HYQ63_RS22685 ENOG4105VEQ Cold shock protein HYQ63_RS22695 ENOG4105VEQ Cold shock protein HYQ63_RS22845 ENOG4105DHP deoxycytidine triphosphate deaminase HYQ63_RS22850 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HYQ63_RS22865 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HYQ63_RS22870 ENOG4105DF6 Fe-S oxidoreductase HYQ63_RS22875 ENOG4105CFG Acts as a chaperone (By similarity) HYQ63_RS22880 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HYQ63_RS22885 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HYQ63_RS22890 ENOG4105KNI merR family transcriptional Regulator HYQ63_RS22900 ENOG4105CSH Transporter HYQ63_RS22910 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HYQ63_RS22935 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HYQ63_RS22950 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HYQ63_RS22955 ENOG4107RCW fructose-bisphosphate aldolase HYQ63_RS22970 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HYQ63_RS22975 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HYQ63_RS22990 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS22995 ENOG4106A3M Cytochrome p-450 HYQ63_RS23005 ENOG4105CIG ABC transporter HYQ63_RS23020 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HYQ63_RS23025 ENOG4108762 serine threonine protein kinase HYQ63_RS23050 ENOG4108KXV response regulator HYQ63_RS23060 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HYQ63_RS23065 ENOG4105DRR Transcriptional regulator, GntR family HYQ63_RS23080 ENOG4105C12 Phosphoribosylglycinamide synthetase HYQ63_RS23100 ENOG4105C8V SAICAR synthetase HYQ63_RS23110 ENOG4108KX4 response regulator HYQ63_RS23125 ENOG4105CJ1 ABC, transporter HYQ63_RS23145 ENOG410839H phosphoribosylformylglycinamidine synthase HYQ63_RS23150 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HYQ63_RS23155 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HYQ63_RS23170 ENOG41061MV Arylsulfatase HYQ63_RS23180 ENOG4105CXB phosphoribosylaminoimidazole synthetase HYQ63_RS23215 ENOG4105CQ7 ATP-dependent helicase HYQ63_RS23255 ENOG410829K Lysine exporter protein (Lyse ygga) HYQ63_RS23260 ENOG4105NX3 Membrane HYQ63_RS23290 ENOG4105EQX glucarate dehydratase HYQ63_RS23315 ENOG4105C1J atp-dependent rna helicase HYQ63_RS23360 ENOG4105E4C Lytic transglycosylase catalytic HYQ63_RS23365 ENOG4105CPC Aldo Keto reductase HYQ63_RS23425 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HYQ63_RS23430 ENOG4105D5U fad dependent oxidoreductase HYQ63_RS23525 ENOG4105E4C Lytic transglycosylase catalytic HYQ63_RS23530 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HYQ63_RS23535 ENOG4105DNP FAD linked oxidase domain protein HYQ63_RS23550 ENOG4105VPX protein, conserved in bacteria HYQ63_RS23560 ENOG4105CJ3 phosphate transporter HYQ63_RS23565 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS23595 ENOG4105TT9 Protein of unknown function (DUF2516) HYQ63_RS23610 ENOG4108IG5 Transcriptional regulator HYQ63_RS23615 ENOG4105CHR reductase HYQ63_RS23620 ENOG4105CPC Aldo Keto reductase HYQ63_RS23630 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HYQ63_RS23640 ENOG4105QCJ Lipoprotein HYQ63_RS23650 ENOG4108X0B nad(p)h dehydrogenase (quinone) HYQ63_RS23660 ENOG4108Z4X TRANSCRIPTIONal HYQ63_RS23665 ENOG4105HHS UPF0256 protein HYQ63_RS23675 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HYQ63_RS23680 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HYQ63_RS23685 ENOG41090R7 Ferric uptake HYQ63_RS23690 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HYQ63_RS23705 ENOG4105PKJ carbohydrate binding HYQ63_RS23710 ENOG4105KHC sulfurtransferase HYQ63_RS23745 ENOG4107NHD transcriptional regulator HYQ63_RS23750 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS23755 ENOG4105C0H protease HYQ63_RS23830 ENOG4105BZ1 (ABC) transporter HYQ63_RS23840 ENOG4105VFU Rna-binding protein HYQ63_RS23850 ENOG4105V75 Transcriptional regulator HYQ63_RS23855 ENOG4105J0Q Transcriptional regulator HYQ63_RS23880 ENOG4105E4C Lytic transglycosylase catalytic HYQ63_RS23885 ENOG4108IG5 Transcriptional regulator HYQ63_RS23895 ENOG4108FKE two-component system sensor kinase HYQ63_RS23900 ENOG4108PYU two-component system response regulator HYQ63_RS23905 ENOG41075QH Lipoprotein CseA HYQ63_RS23910 ENOG4105NAF rna polymerase sigma factor HYQ63_RS23915 ENOG4105CEN a g-specific adenine glycosylase HYQ63_RS23925 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HYQ63_RS23940 ENOG4108JWX HYQ63_RS23945 ENOG4107R33 ppx gppa phosphatase HYQ63_RS23950 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HYQ63_RS23960 ENOG4105C01 Dihydroxy-acid dehydratase HYQ63_RS23965 ENOG4108762 serine threonine protein kinase HYQ63_RS23985 ENOG4105II7 pyrroline-5-carboxylate reductase HYQ63_RS23990 ENOG4105C31 Tryptophanyl-tRNA synthetase HYQ63_RS24010 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HYQ63_RS24020 ENOG4105DGU Histone deacetylase HYQ63_RS24025 ENOG4108XFF HYQ63_RS24070 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HYQ63_RS24075 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HYQ63_RS24080 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HYQ63_RS24085 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HYQ63_RS24090 ENOG4105D52 delta-aminolevulinic acid dehydratase HYQ63_RS24105 ENOG4107Z1W Fructose transport system kinase HYQ63_RS24140 ENOG4105C75 arginyL-tRNA synthetase HYQ63_RS24145 ENOG4105DK7 lysyl-tRNA synthetase HYQ63_RS24165 ENOG4105E0Y RtcB Protein HYQ63_RS24180 ENOG4105KK4 UPF0060 membrane protein HYQ63_RS24190 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HYQ63_RS24195 ENOG4108RH7 phosphoglycerate mutase HYQ63_RS24215 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HYQ63_RS24220 ENOG4105CRE cytochrome C HYQ63_RS24230 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HYQ63_RS24235 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HYQ63_RS24240 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HYQ63_RS24255 ENOG4105DVY radical SAM domain protein HYQ63_RS24260 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HYQ63_RS24275 ENOG4105CK2 sodium dicarboxylate symporter HYQ63_RS24305 ENOG4108IG5 Transcriptional regulator HYQ63_RS24330 ENOG4105VEQ Cold shock protein HYQ63_RS24335 ENOG4105EV6 Pfam:DUF178 HYQ63_RS24345 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HYQ63_RS24355 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HYQ63_RS24360 ENOG4105KNA -acetyltransferase HYQ63_RS24390 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS24395 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HYQ63_RS24400 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS24410 ENOG4107QIZ NADH dehydrogenase HYQ63_RS24415 ENOG4108IEH NADH dehydrogenase subunit g HYQ63_RS24420 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HYQ63_RS24425 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS24430 ENOG41087XN oxidoreductase HYQ63_RS24435 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS24440 ENOG4105D65 subunit l HYQ63_RS24450 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS24470 ENOG4105CAY ferredoxin--nadp reductase HYQ63_RS24505 ENOG4105ECR NmrA family HYQ63_RS24510 ENOG4105KVH Transcriptional regulator HYQ63_RS24515 ENOG4105DQU oxidoreductase, subunit beta HYQ63_RS24520 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HYQ63_RS24525 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS24540 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HYQ63_RS24545 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS24550 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HYQ63_RS24555 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HYQ63_RS24560 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS24565 ENOG4107YX3 NADH dehydrogenase subunit j HYQ63_RS24570 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS24575 ENOG4105D65 subunit l HYQ63_RS24580 ENOG4105C8S subunit m HYQ63_RS24585 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYQ63_RS24590 ENOG4105D0M Protease HtpX homolog HYQ63_RS24595 ENOG410901E Membrane HYQ63_RS24610 ENOG4108VPT UPF0234 protein HYQ63_RS24620 ENOG4105CZE histidine utilization repressor HYQ63_RS24635 ENOG4108HMN Caspase domain HYQ63_RS24650 ENOG4105DZC cytosine deaminase HYQ63_RS24665 ENOG4105WDJ 50S ribosomal protein L33 HYQ63_RS24670 ENOG410900P UPF0336 protein HYQ63_RS24680 ENOG4107R4N Cell wall formation (By similarity) HYQ63_RS24705 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HYQ63_RS24710 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HYQ63_RS24715 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HYQ63_RS24725 ENOG4108VZM 50s ribosomal protein L10 HYQ63_RS24730 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HYQ63_RS24735 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HYQ63_RS24740 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HYQ63_RS24745 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HYQ63_RS24750 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HYQ63_RS24755 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HYQ63_RS24760 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HYQ63_RS24790 ENOG4105EMN RNA polymerase sigma factor HYQ63_RS24800 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HYQ63_RS24805 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HYQ63_RS24810 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HYQ63_RS24815 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HYQ63_RS24820 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HYQ63_RS24825 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HYQ63_RS24830 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HYQ63_RS24835 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HYQ63_RS24840 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HYQ63_RS24845 ENOG41082SA 50s ribosomal protein l29 HYQ63_RS24850 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HYQ63_RS24855 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HYQ63_RS24860 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HYQ63_RS24865 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HYQ63_RS24870 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HYQ63_RS24875 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HYQ63_RS24880 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HYQ63_RS24885 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HYQ63_RS24890 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HYQ63_RS24900 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HYQ63_RS24910 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HYQ63_RS24920 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HYQ63_RS24930 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HYQ63_RS24935 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HYQ63_RS24940 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HYQ63_RS24945 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HYQ63_RS24950 ENOG4108ZT0 50S ribosomal protein l17 HYQ63_RS24955 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HYQ63_RS24960 ENOG4107MMM Anti-sigma-factor antagonist HYQ63_RS24965 ENOG4105FUA antagonist HYQ63_RS24970 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HYQ63_RS24990 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HYQ63_RS25040 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HYQ63_RS25045 ENOG4108UJD 30S ribosomal protein S9 HYQ63_RS25050 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HYQ63_RS25060 ENOG4105CS9 pantothenic acid kinase HYQ63_RS25065 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HYQ63_RS25105 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HYQ63_RS25115 ENOG4108097 ATP-binding protein HYQ63_RS25140 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HYQ63_RS25185 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HYQ63_RS25190 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HYQ63_RS25200 ENOG4105DND Transcriptional regulator HYQ63_RS25205 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HYQ63_RS25210 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS25215 ENOG4108MMM RNA Polymerase HYQ63_RS25225 ENOG4107QVP Dehydrogenase HYQ63_RS25240 ENOG4105DFF Rod shape-determining protein mreb HYQ63_RS25250 ENOG4107QQG Dehydrogenase HYQ63_RS25255 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HYQ63_RS25275 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS25280 ENOG4105CC9 acyl-Coa dehydrogenase HYQ63_RS25285 ENOG4105D2B acyl-CoA dehydrogenase HYQ63_RS25305 ENOG4105CC9 acyl-Coa dehydrogenase HYQ63_RS25310 ENOG4105C26 Dehydrogenase HYQ63_RS25315 ENOG4107QPD alcohol dehydrogenase HYQ63_RS25320 ENOG4105ECQ AraC Family Transcriptional Regulator HYQ63_RS25330 ENOG4105MXW flavin reductase domain protein, FMN-binding HYQ63_RS25335 ENOG4105CGU Enoyl-CoA hydratase HYQ63_RS25345 ENOG4105H3G oxidoreductase HYQ63_RS25360 ENOG4105GWZ Roadblock lc7 family protein HYQ63_RS25385 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HYQ63_RS25395 ENOG4105D2B acyl-CoA dehydrogenase HYQ63_RS25405 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HYQ63_RS25415 ENOG4108762 serine threonine protein kinase HYQ63_RS25440 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS25455 ENOG4105F0K SARP family transcriptional regulator HYQ63_RS25470 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HYQ63_RS25490 ENOG4105CHR reductase HYQ63_RS25510 ENOG4105MC2 DSBA oxidoreductase HYQ63_RS25515 ENOG4105CHR reductase HYQ63_RS25535 ENOG4108R0M Aminoglycoside HYQ63_RS25590 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HYQ63_RS25600 ENOG41066UM arsR family transcriptional regulator HYQ63_RS25635 ENOG41065RQ ADP-ribosylation crystallin J1 HYQ63_RS25675 ENOG4105DZ1 carboxypeptidase HYQ63_RS25685 ENOG4105EPJ extracellular solute-binding protein family 1 HYQ63_RS25695 ENOG4107Q25 Serine Threonine protein kinase HYQ63_RS25790 ENOG4105FDF Could be involved in DNA repair (By similarity) HYQ63_RS25795 ENOG4105DQE DNA ligase HYQ63_RS25805 ENOG4105K6H D-cysteine desulfhydrase HYQ63_RS25815 ENOG4108KGH TRANSCRIPTIONal HYQ63_RS25825 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HYQ63_RS25830 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HYQ63_RS25850 ENOG4108UGD Serine Threonine protein kinase HYQ63_RS25860 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS26030 ENOG4105J7D transcriptional regulator HYQ63_RS26050 ENOG4107QJT sodium dicarboxylate symporter HYQ63_RS26065 ENOG4105DND Transcriptional regulator HYQ63_RS26075 ENOG4107T94 Endo-14-beta-xylanase HYQ63_RS26095 ENOG4105NPE arsR family transcriptional regulator HYQ63_RS26100 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HYQ63_RS26120 ENOG4107TXC Transcriptional regulator HYQ63_RS26170 ENOG4105DUU IucA IucC family protein HYQ63_RS26180 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HYQ63_RS26185 ENOG4105DY8 decarboxylase HYQ63_RS26225 ENOG4105EJ2 Transcriptional regulator HYQ63_RS26250 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HYQ63_RS26265 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HYQ63_RS26270 ENOG410804X Transcriptional regulator HYQ63_RS26275 ENOG4105DE4 1-phosphofructokinase HYQ63_RS26295 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HYQ63_RS26305 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HYQ63_RS26315 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HYQ63_RS26325 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HYQ63_RS26335 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HYQ63_RS26340 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HYQ63_RS26350 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HYQ63_RS26355 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HYQ63_RS26360 ENOG4105D9U N-acetyltransferase HYQ63_RS26375 ENOG410829K Lysine exporter protein (Lyse ygga) HYQ63_RS26400 ENOG4105CGK Exodeoxyribonuclease III HYQ63_RS26410 ENOG4105F95 Monooxygenase HYQ63_RS26420 ENOG4105CHR reductase HYQ63_RS26440 ENOG4105EYF MMPL domain protein HYQ63_RS26445 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HYQ63_RS26455 ENOG4108JJB ABC transporter HYQ63_RS26480 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HYQ63_RS26490 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HYQ63_RS26505 ENOG4105CJN penicillin-binding protein HYQ63_RS26525 ENOG4105F8V Hydrolase, tatD family HYQ63_RS26535 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HYQ63_RS26540 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HYQ63_RS26545 ENOG4105C5H ABC transporter HYQ63_RS26580 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HYQ63_RS26585 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS26590 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HYQ63_RS26595 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HYQ63_RS26600 ENOG41067SE Tetr family transcriptional regulator HYQ63_RS26610 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HYQ63_RS26620 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HYQ63_RS26625 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HYQ63_RS26630 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HYQ63_RS26635 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HYQ63_RS26645 ENOG4105BZU Histidine kinase HYQ63_RS26680 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HYQ63_RS26695 ENOG4105CPC Aldo Keto reductase HYQ63_RS26705 ENOG4108Z6Z Transcriptional regulator HYQ63_RS26710 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HYQ63_RS26740 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HYQ63_RS26750 ENOG4108XNA Gas vesicle HYQ63_RS26830 ENOG4105WBV Transcriptional regulator HYQ63_RS26835 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HYQ63_RS26840 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HYQ63_RS26865 ENOG4105BZU Histidine kinase HYQ63_RS26870 ENOG4105GWZ Roadblock lc7 family protein HYQ63_RS26890 ENOG4105YVS arsR family transcriptional regulator HYQ63_RS26895 ENOG4108RQ5 Beta-lactamase domain-containing protein HYQ63_RS26930 ENOG4105CPC Aldo Keto reductase HYQ63_RS26980 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HYQ63_RS27000 ENOG4105NAF rna polymerase sigma factor HYQ63_RS27010 ENOG4105C7B Threonine dehydratase HYQ63_RS27025 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HYQ63_RS27035 ENOG4105T1M mycothiol conjugate amidase mca HYQ63_RS27055 ENOG4105F27 Major Facilitator HYQ63_RS27065 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HYQ63_RS27075 ENOG4105C7Z Conserved Protein HYQ63_RS27085 ENOG4108UT2 hemolysin iii HYQ63_RS27090 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HYQ63_RS27095 ENOG4105DIA mandelate racemase muconate lactonizing HYQ63_RS27100 ENOG4108UVJ appr-1-p processing domain protein HYQ63_RS27120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYQ63_RS27125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS27170 ENOG4108FUF Transcriptional regulator, IclR family HYQ63_RS27180 ENOG4105C6Z Gluconate HYQ63_RS27205 ENOG4107QMS site-determining protein HYQ63_RS27245 ENOG4107QKZ Ompa motb domain protein HYQ63_RS27250 ENOG4107R5R arsenical pump membrane protein HYQ63_RS27275 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HYQ63_RS27280 ENOG4108IAB Phoh family HYQ63_RS27295 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HYQ63_RS27300 ENOG4105D3R alkyl hydroperoxide reductase HYQ63_RS27315 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HYQ63_RS27335 ENOG4105BZ4 penicillin-binding protein HYQ63_RS27355 ENOG4105C9Q fumarate hydratase class II HYQ63_RS27370 ENOG4108NNZ chitinase HYQ63_RS27375 ENOG4107GFK fumarate HYQ63_RS27385 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HYQ63_RS27400 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HYQ63_RS27405 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HYQ63_RS27410 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HYQ63_RS27415 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HYQ63_RS27430 ENOG4105C3G gtp-binding protein HYQ63_RS27445 ENOG4105CJA serine threonine protein kinase HYQ63_RS27460 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS27485 ENOG4107QTZ amino acid HYQ63_RS27515 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HYQ63_RS27535 ENOG4105CI3 gtp-binding protein typa HYQ63_RS27545 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYQ63_RS27550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS27555 ENOG4105C3U ABC transporter HYQ63_RS27560 ENOG4108JQ7 (ABC) transporter HYQ63_RS27565 ENOG4105E0S extracellular solute-binding protein family 1 HYQ63_RS27570 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HYQ63_RS27580 ENOG4108HIY periplasmic HYQ63_RS27585 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYQ63_RS27590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS27595 ENOG4105C3U ABC transporter HYQ63_RS27600 ENOG4108JQ7 (ABC) transporter HYQ63_RS27615 ENOG4105ECQ AraC Family Transcriptional Regulator HYQ63_RS27655 ENOG4105MHT Transcriptional regulator, ARSR family HYQ63_RS27665 ENOG4108JQ7 (ABC) transporter HYQ63_RS27680 ENOG4105DEF Extracellular solute-binding protein, family 5 HYQ63_RS27685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS27705 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HYQ63_RS27720 ENOG4108M15 ABC transporter HYQ63_RS27730 ENOG4105BZU Histidine kinase HYQ63_RS27735 ENOG4108S01 response regulator HYQ63_RS27750 ENOG4108Z4U Ferredoxin HYQ63_RS27770 ENOG4107R4C succinyl-diaminopimelate desuccinylase HYQ63_RS27775 ENOG4108URH decarboxylase HYQ63_RS27780 ENOG4105EEI dihydropteroate synthase HYQ63_RS27790 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HYQ63_RS27795 ENOG4105CGU Enoyl-CoA hydratase HYQ63_RS27810 ENOG4105DU6 RNA polymerase HYQ63_RS27820 ENOG4105C0H protease HYQ63_RS27825 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HYQ63_RS27865 ENOG4105D7N magnesium and cobalt transport protein CorA HYQ63_RS27880 ENOG4105DB7 PHP domain protein HYQ63_RS27895 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HYQ63_RS27900 ENOG4105C1J atp-dependent rna helicase HYQ63_RS27990 ENOG4105C4R Atp-dependent dna helicase HYQ63_RS27995 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HYQ63_RS28020 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HYQ63_RS28085 ENOG41063PX domain protein HYQ63_RS28095 ENOG4105DJZ UPF0182 protein HYQ63_RS28130 ENOG4107TK4 histidinol-phosphate phosphatase HYQ63_RS28140 ENOG4105KPY Small multidrug resistance protein HYQ63_RS28150 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HYQ63_RS28160 ENOG4108RAV Conserved protein HYQ63_RS28170 ENOG4105EMN RNA polymerase sigma factor HYQ63_RS28175 ENOG4105WMN AntiSigma factor HYQ63_RS28180 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HYQ63_RS28195 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HYQ63_RS28200 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HYQ63_RS28205 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HYQ63_RS28215 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HYQ63_RS28220 ENOG4105E98 transcriptional regulator DeoR family HYQ63_RS28260 ENOG4105FDP GntR family transcriptional regulator HYQ63_RS28265 ENOG4105D17 glycoside hydrolase, family 3 domain protein HYQ63_RS28270 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HYQ63_RS28285 ENOG4105CBD Diacylglycerol kinase HYQ63_RS28325 ENOG4105CSV Glutaminase HYQ63_RS28345 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HYQ63_RS28370 ENOG4105S7M extracellular small neutral protease HYQ63_RS28375 ENOG4108KXM LysR family Transcriptional regulator HYQ63_RS28390 ENOG4108VEQ Superoxide dismutase HYQ63_RS28410 ENOG4105CDA abc transporter atp-binding protein HYQ63_RS28415 ENOG4105DRP amino acid AbC transporter HYQ63_RS28425 ENOG4105C6K Malic enzyme HYQ63_RS28430 ENOG4105CB2 alcohol dehydrogenase HYQ63_RS28455 ENOG4105C0W non-ribosomal peptide synthetase HYQ63_RS28470 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HYQ63_RS28490 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HYQ63_RS28500 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HYQ63_RS28510 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HYQ63_RS28515 ENOG4105EB3 Histidine kinase HYQ63_RS28520 ENOG4108PYU two-component system response regulator HYQ63_RS28535 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HYQ63_RS28540 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HYQ63_RS28590 ENOG4105K4H Nlp p60 protein HYQ63_RS28630 ENOG4105XYF acetyltransferase HYQ63_RS28640 ENOG4106NZI LysR family Transcriptional regulator HYQ63_RS28645 ENOG4105F27 Major Facilitator HYQ63_RS28715 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HYQ63_RS28720 ENOG4105C75 arginyL-tRNA synthetase HYQ63_RS28725 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HYQ63_RS28730 ENOG4105D6E homoserine dehydrogenase HYQ63_RS28735 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HYQ63_RS28740 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HYQ63_RS28750 ENOG4108KGH TRANSCRIPTIONal HYQ63_RS28755 ENOG4105VFB Binds the 23S rRNA (By similarity) HYQ63_RS28760 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HYQ63_RS28765 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HYQ63_RS28775 ENOG4107ZF2 Phosphatase HYQ63_RS28780 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HYQ63_RS28800 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) HYQ63_RS28805 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HYQ63_RS28860 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HYQ63_RS28895 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HYQ63_RS28925 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HYQ63_RS28940 ENOG4105ESV Glycosyl transferase, family 4 HYQ63_RS28945 ENOG4105Z3P ATP synthase HYQ63_RS28955 ENOG4105ZA1 atp synthase HYQ63_RS28960 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HYQ63_RS28965 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HYQ63_RS28970 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HYQ63_RS28975 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HYQ63_RS28980 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HYQ63_RS28985 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HYQ63_RS28995 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS29000 ENOG4108XG2 Histidine kinase HYQ63_RS29005 ENOG4105IIP Membrane HYQ63_RS29025 ENOG410630P Transcriptional regulator HYQ63_RS29030 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HYQ63_RS29045 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HYQ63_RS29055 ENOG4108M8W Monooxygenase HYQ63_RS29095 ENOG4105CHU acetyl-coa acetyltransferase HYQ63_RS29105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYQ63_RS29200 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HYQ63_RS29210 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HYQ63_RS29215 ENOG4105C6K Malic enzyme HYQ63_RS29220 ENOG4105CTQ phosphohexokinase HYQ63_RS29235 ENOG4105EG2 ABC transporter, permease HYQ63_RS29240 ENOG4108KGH TRANSCRIPTIONal HYQ63_RS29245 ENOG4107QJZ Glycosyl transferase, family 2 HYQ63_RS29255 ENOG4108KPJ rna polymerase sigma factor HYQ63_RS29260 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HYQ63_RS29280 ENOG4105FQP Beta-lactamase HYQ63_RS29375 ENOG4105I6B RNA polymerase HYQ63_RS29395 ENOG4106UDK Cellulose-binding, family II HYQ63_RS29400 ENOG4108MRH transcriptional regulatory protein HYQ63_RS29405 ENOG4105ES5 Histidine kinase HYQ63_RS29410 ENOG4107QJT sodium dicarboxylate symporter HYQ63_RS29430 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HYQ63_RS29435 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HYQ63_RS29445 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HYQ63_RS29450 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HYQ63_RS29455 ENOG4108E16 pectate lyase HYQ63_RS29465 ENOG4105CX8 fg-gap repeat protein HYQ63_RS29470 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HYQ63_RS29475 ENOG4105CVA phosphate HYQ63_RS29500 ENOG4105BZ1 (ABC) transporter HYQ63_RS29505 ENOG4105BZ1 (ABC) transporter HYQ63_RS29515 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HYQ63_RS29560 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HYQ63_RS29570 ENOG4105EJQ L-serine dehydratase HYQ63_RS29575 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HYQ63_RS29580 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HYQ63_RS29585 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HYQ63_RS29610 ENOG4108J59 Extracellular solute-binding protein, family 5 HYQ63_RS29625 ENOG4108JQ7 (ABC) transporter HYQ63_RS29630 ENOG4105EN6 Membrane HYQ63_RS29670 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HYQ63_RS29730 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HYQ63_RS29735 ENOG4105BZU Histidine kinase HYQ63_RS29740 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HYQ63_RS29745 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HYQ63_RS29755 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HYQ63_RS29765 ENOG4105DEF Extracellular solute-binding protein, family 5 HYQ63_RS29775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS29790 ENOG4105EYF MMPL domain protein HYQ63_RS29805 ENOG4105CPC Aldo Keto reductase HYQ63_RS29815 ENOG4105BZU Histidine kinase HYQ63_RS29825 ENOG4108ZP8 Acetolactate synthase small subunit HYQ63_RS29830 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HYQ63_RS29880 ENOG4105C26 Dehydrogenase HYQ63_RS29890 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HYQ63_RS29895 ENOG4105CM2 brancheD-chain amino acid aminotransferase HYQ63_RS29900 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HYQ63_RS29905 ENOG4108YYC ycei family HYQ63_RS29915 ENOG4105D8K carboxyl transferase HYQ63_RS29935 ENOG4105GWZ Roadblock lc7 family protein HYQ63_RS29955 ENOG4105GWZ Roadblock lc7 family protein HYQ63_RS29970 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HYQ63_RS29975 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HYQ63_RS30015 ENOG41069M3 Transcriptional regulator HYQ63_RS30020 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HYQ63_RS30025 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HYQ63_RS30035 ENOG4105K70 DNA-binding protein HYQ63_RS30055 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HYQ63_RS30060 ENOG4105CPF Cell wall formation (By similarity) HYQ63_RS30080 ENOG4105DWF phosphomethylpyrimidine kinase HYQ63_RS30085 ENOG4105VB9 50S ribosomal protein l28 HYQ63_RS30090 ENOG4105DP4 dak2 domain fusion protein ylov HYQ63_RS30100 ENOG4106H78 methyltransferase HYQ63_RS30105 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HYQ63_RS30120 ENOG41084BZ 50S ribosomal protein L32 HYQ63_RS30125 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HYQ63_RS30130 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HYQ63_RS30135 ENOG4105KVH Transcriptional regulator HYQ63_RS30145 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HYQ63_RS30155 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HYQ63_RS30180 ENOG4108XG2 Histidine kinase HYQ63_RS30185 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS30215 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HYQ63_RS30230 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HYQ63_RS30240 ENOG4105K5M 30s ribosomal protein S16 HYQ63_RS30245 ENOG41082KU UPF0109 protein HYQ63_RS30250 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HYQ63_RS30255 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HYQ63_RS30260 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HYQ63_RS30275 ENOG4107QYR Signal peptidase i HYQ63_RS30280 ENOG4107QYR Signal peptidase i HYQ63_RS30285 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HYQ63_RS30295 ENOG41080R2 UPF0102 protein HYQ63_RS30330 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYQ63_RS30345 ENOG4105CE9 30S ribosomal protein S2 HYQ63_RS30350 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HYQ63_RS30355 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HYQ63_RS30360 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HYQ63_RS30365 ENOG4105KNE Phosphatidate cytidylyltransferase HYQ63_RS30370 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HYQ63_RS30380 ENOG4108I5D sulfate abc transporter HYQ63_RS30385 ENOG4108UCS ABC, transporter HYQ63_RS30400 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HYQ63_RS30405 ENOG4105C7K acetolactate synthase HYQ63_RS30420 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HYQ63_RS30430 ENOG4105C26 Dehydrogenase HYQ63_RS30440 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HYQ63_RS30455 ENOG4107RUE extracellular solute-binding protein family 1 HYQ63_RS30460 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS30465 ENOG4105F38 ABC transporter, permease HYQ63_RS30470 ENOG4105D38 putrescine abc transporter HYQ63_RS30475 ENOG4105CJP fad dependent oxidoreductase HYQ63_RS30495 ENOG4105G9B Transcriptional regulator HYQ63_RS30520 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HYQ63_RS30540 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS30550 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HYQ63_RS30555 ENOG4105DZP Membrane-associated zinc metalloprotease HYQ63_RS30560 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HYQ63_RS30575 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HYQ63_RS30595 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HYQ63_RS30610 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HYQ63_RS30620 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HYQ63_RS30625 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HYQ63_RS30650 ENOG4108T50 Protein of unknown function (DUF690) HYQ63_RS30705 ENOG4105EC2 ftsk spoIIIe HYQ63_RS30735 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HYQ63_RS30795 ENOG4108762 serine threonine protein kinase HYQ63_RS30810 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HYQ63_RS30815 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HYQ63_RS30820 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HYQ63_RS30825 ENOG4105C1V Peptidase, M16 HYQ63_RS30830 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HYQ63_RS30855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYQ63_RS30860 ENOG4105CN5 Metallo-Beta-Lactamase HYQ63_RS30895 ENOG4105BZU Histidine kinase HYQ63_RS30900 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HYQ63_RS30905 ENOG4107QZI cell division protein FtsK HYQ63_RS30915 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HYQ63_RS30925 ENOG4105CEV competence damage-inducible protein HYQ63_RS30930 ENOG4105WBV Transcriptional regulator HYQ63_RS30940 ENOG4105CHR reductase HYQ63_RS30945 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HYQ63_RS30950 ENOG4107QRT dEAD DEAH box helicase HYQ63_RS30970 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HYQ63_RS30990 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HYQ63_RS30995 ENOG4105DRP amino acid AbC transporter HYQ63_RS31000 ENOG4105EAD ABC transporter HYQ63_RS31005 ENOG4105E89 ABC transporter HYQ63_RS31010 ENOG4105CDA abc transporter atp-binding protein HYQ63_RS31020 ENOG4105EB3 Histidine kinase HYQ63_RS31030 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HYQ63_RS31050 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HYQ63_RS31060 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HYQ63_RS31065 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HYQ63_RS31075 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HYQ63_RS31105 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HYQ63_RS31110 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HYQ63_RS31115 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HYQ63_RS31120 ENOG4105CIH Imidazole acetol-phosphate transaminase HYQ63_RS31140 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HYQ63_RS31150 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HYQ63_RS31170 ENOG4105C9U ATP-dependent DNA helicase RecQ HYQ63_RS31200 ENOG4105CIH Imidazole acetol-phosphate transaminase HYQ63_RS31205 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HYQ63_RS31255 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS31260 ENOG4105C6F GntR Family Transcriptional Regulator HYQ63_RS31265 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYQ63_RS31270 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HYQ63_RS31280 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYQ63_RS31290 ENOG4107QN1 sodium solute HYQ63_RS31295 ENOG4108MRH transcriptional regulatory protein HYQ63_RS31300 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HYQ63_RS31315 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYQ63_RS31335 ENOG4105DRR Transcriptional regulator, GntR family HYQ63_RS31340 ENOG410849S phosphocarrier protein (HPr) HYQ63_RS31360 ENOG4107W53 thymidine kinase HYQ63_RS31390 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HYQ63_RS31405 ENOG4105F44 Two component transcriptional regulator, winged helix family HYQ63_RS31410 ENOG4106F60 Histidine kinase HYQ63_RS31435 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HYQ63_RS31455 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HYQ63_RS31460 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HYQ63_RS31465 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HYQ63_RS31495 ENOG4107VEG TrkA-N domain protein HYQ63_RS31525 ENOG4105C0X amino acid HYQ63_RS31530 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HYQ63_RS31565 ENOG4107QK5 Homocysteine s-methyltransferase HYQ63_RS31575 ENOG4107S1Q Phosphatase HYQ63_RS31600 ENOG4105CEU Arginine dihydrolase HYQ63_RS31605 ENOG4105DBV ornithine carbamoyltransferase HYQ63_RS31615 ENOG4108UKI Enoyl-CoA hydratase HYQ63_RS31620 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYQ63_RS31645 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HYQ63_RS31680 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS31695 ENOG4107R6D beta-lactam binding protein AmpH HYQ63_RS31700 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HYQ63_RS31730 ENOG4107QM5 aconitate hydratase HYQ63_RS31755 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HYQ63_RS31775 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HYQ63_RS31790 ENOG4105DFW ABC transporter HYQ63_RS31795 ENOG4105C2J ABC transporter HYQ63_RS31800 ENOG4108HWW ABC transporter HYQ63_RS31805 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HYQ63_RS31810 ENOG4105CUB amino acid HYQ63_RS31825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HYQ63_RS31830 ENOG4105CHU acetyl-coa acetyltransferase HYQ63_RS31850 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HYQ63_RS31855 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HYQ63_RS31860 ENOG4105DJB Major Facilitator Superfamily HYQ63_RS31875 ENOG4107HP6 Transcriptional regulator HYQ63_RS31880 ENOG4105C1Q protoporphyrinogen oxidase HYQ63_RS31885 ENOG4107JTW chlorite dismutase HYQ63_RS31900 ENOG4105E18 UPF0276 protein HYQ63_RS31905 ENOG4105BZ4 penicillin-binding protein HYQ63_RS31945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYQ63_RS31950 ENOG4105BZU Histidine kinase HYQ63_RS32000 ENOG4105DFU Cell wall formation (By similarity) HYQ63_RS32005 ENOG4105E0X reductase HYQ63_RS32025 ENOG4108KB2 LysR family Transcriptional regulator HYQ63_RS32080 ENOG4105DKW ABC transporter HYQ63_RS32085 ENOG4105FDP GntR family transcriptional regulator HYQ63_RS32105 ENOG4105F8J Adenylate Guanylate cyclase HYQ63_RS32150 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HYQ63_RS32195 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HYQ63_RS32200 ENOG4107QND Nitrite extrusion protein HYQ63_RS32215 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS32220 ENOG4105C0W non-ribosomal peptide synthetase HYQ63_RS32265 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HYQ63_RS32280 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HYQ63_RS32285 ENOG4108IY8 ABC, transporter HYQ63_RS32310 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HYQ63_RS32360 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HYQ63_RS32365 ENOG4107QN2 dihydrolipoyl dehydrogenase HYQ63_RS32415 ENOG4105DRR Transcriptional regulator, GntR family HYQ63_RS32440 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HYQ63_RS32445 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HYQ63_RS32485 ENOG4105D7N magnesium and cobalt transport protein CorA HYQ63_RS32500 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HYQ63_RS32505 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS32555 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HYQ63_RS32565 ENOG4107R9S Malate synthase HYQ63_RS32570 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HYQ63_RS32580 ENOG4105J4Q Transcriptional regulator HYQ63_RS32590 ENOG4105DHG Allantoate amidinohydrolase HYQ63_RS32645 ENOG4108RTU Aldolase HYQ63_RS32650 ENOG4105F87 Dehydratase HYQ63_RS32685 ENOG4105KV4 Transcriptional regulator HYQ63_RS32695 ENOG4105C4C beta-galactosidase HYQ63_RS32705 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYQ63_RS32710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS32715 ENOG4105C3U ABC transporter HYQ63_RS32730 ENOG4105D4B ABC, transporter HYQ63_RS32735 ENOG41062B0 ABC transporter, permease HYQ63_RS32740 ENOG4105C2J ABC transporter HYQ63_RS32745 ENOG4105DKQ ROK family HYQ63_RS32755 ENOG4105F2Z 3-oxoadipate enol-lactonase HYQ63_RS32785 ENOG4105CDA abc transporter atp-binding protein HYQ63_RS32790 ENOG4107UBR Extracellular solute-binding protein family 3 HYQ63_RS32795 ENOG4105EAD ABC transporter HYQ63_RS32800 ENOG4105DRP amino acid AbC transporter HYQ63_RS32815 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HYQ63_RS32830 ENOG4105C8Y Acetylornithine aminotransferase HYQ63_RS32835 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HYQ63_RS32850 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HYQ63_RS32865 ENOG4105E2R ROK family HYQ63_RS32875 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HYQ63_RS32885 ENOG4105CHR reductase HYQ63_RS32895 ENOG4105C2J ABC transporter HYQ63_RS32900 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HYQ63_RS32905 ENOG4105CNN ABC, transporter HYQ63_RS32910 ENOG4105CHR reductase HYQ63_RS32915 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HYQ63_RS32920 ENOG4108IUS Transketolase HYQ63_RS32925 ENOG4108HHA Transketolase HYQ63_RS32930 ENOG4105ECY inositol monophosphatase HYQ63_RS32950 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HYQ63_RS32985 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HYQ63_RS33005 ENOG4105BZW Glycerate kinase HYQ63_RS33015 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HYQ63_RS33020 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS33030 ENOG4105CI0 Citrate lyase HYQ63_RS33050 ENOG4105CGS Alpha-glucosidase HYQ63_RS33090 ENOG4108Q50 Histidine kinase HYQ63_RS33100 ENOG4108ME1 Peptidase M55 D-aminopeptidase HYQ63_RS33105 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HYQ63_RS33135 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HYQ63_RS33160 ENOG4105CH6 catalase HYQ63_RS33165 ENOG4108Z0Z intracellular protease Pfpi family HYQ63_RS33170 ENOG4105DIA mandelate racemase muconate lactonizing HYQ63_RS33180 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HYQ63_RS33230 ENOG4105KTE polyketide synthesis cyclase HYQ63_RS33240 ENOG41079R3 acyl carrier protein HYQ63_RS33255 ENOG4105GCH Cupin 2 Conserved Barrel Domain Protein HYQ63_RS33275 ENOG4105E8R UPF0173 metal-dependent hydrolase HYQ63_RS33335 ENOG4106JDR secreted HYQ63_RS33375 ENOG4105KME endoribonuclease L-psp HYQ63_RS33380 ENOG4105KVH Transcriptional regulator HYQ63_RS33410 ENOG4105D5Q Arginine ornithine antiporter HYQ63_RS33435 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HYQ63_RS33505 ENOG4105F95 Monooxygenase HYQ63_RS33525 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HYQ63_RS33535 ENOG4107R13 MMPL domain protein HYQ63_RS33540 ENOG4105CSH Transporter HYQ63_RS33555 ENOG410842T Pterin carbinolamine dehydratase HYQ63_RS33560 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYQ63_RS33570 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HYQ63_RS33575 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HYQ63_RS33585 ENOG4105CVP deoxyribo-dipyrimidine photolyase HYQ63_RS33590 ENOG4105RNG membrane HYQ63_RS33595 ENOG4105K6V RNA polymerase HYQ63_RS33600 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HYQ63_RS33605 ENOG4106T9R serine protease HYQ63_RS33610 ENOG4105CV8 reductase HYQ63_RS33620 ENOG4108IQE Amp-dependent synthetase and ligase HYQ63_RS33625 ENOG4107653 Transcriptional regulator HYQ63_RS33630 ENOG4105DHU Bile acid HYQ63_RS33650 ENOG4108VHT MarR family transcriptional regulator HYQ63_RS33665 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HYQ63_RS33675 ENOG4108IND Tetr family transcriptional regulator HYQ63_RS33680 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HYQ63_RS33695 ENOG4105DKQ ROK family HYQ63_RS33700 ENOG4105C2J ABC transporter HYQ63_RS33705 ENOG4105CNN ABC, transporter HYQ63_RS33710 ENOG4105DFW ABC transporter HYQ63_RS33780 ENOG4105CN5 Metallo-Beta-Lactamase HYQ63_RS33790 ENOG4105DXC membrane HYQ63_RS33820 ENOG4105CXN decarboxylase HYQ63_RS33830 ENOG4105E2R ROK family HYQ63_RS33840 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HYQ63_RS33860 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HYQ63_RS33865 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS33870 ENOG4106M32 3-dehydroquinate synthase HYQ63_RS33875 ENOG41061GT Aldolase HYQ63_RS33885 ENOG4105C57 major facilitator superfamily HYQ63_RS33900 ENOG4105ETX regulatoR HYQ63_RS33910 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HYQ63_RS33920 ENOG4107SQU synthase HYQ63_RS33930 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HYQ63_RS33935 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS33960 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HYQ63_RS33970 ENOG4108UZX fmn reductase HYQ63_RS33980 ENOG4105FBW Monooxygenase HYQ63_RS34005 ENOG4105EQX glucarate dehydratase HYQ63_RS34010 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HYQ63_RS34015 ENOG4107HP6 Transcriptional regulator HYQ63_RS34020 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HYQ63_RS34055 ENOG4105CUB amino acid HYQ63_RS34090 ENOG4105KF0 sporulation and cell division protein, SsgA HYQ63_RS34105 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HYQ63_RS34115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYQ63_RS34125 ENOG410846T CoA-transferase family III HYQ63_RS34130 ENOG4105CHU acetyl-coa acetyltransferase HYQ63_RS34135 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HYQ63_RS34150 ENOG4105CNT hydrolase family 2 HYQ63_RS34175 ENOG4105C94 Transporter HYQ63_RS34185 ENOG4105C5H ABC transporter HYQ63_RS34190 ENOG4105BZM domain protein HYQ63_RS34205 ENOG4105E39 Enoyl-CoA hydratase HYQ63_RS34215 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HYQ63_RS34260 ENOG4105EY8 ABC transporter HYQ63_RS34270 ENOG4105FBD synthase HYQ63_RS34280 ENOG4107S11 squalene-associated FAD-dependent desaturase HYQ63_RS34290 ENOG4105EWU Squalene--hopene cyclase HYQ63_RS34305 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HYQ63_RS34330 ENOG41090WU lipolytic protein G-D-S-L family HYQ63_RS34415 ENOG4108Z86 Glutamine amidotransferase HYQ63_RS34420 ENOG4105CUB amino acid HYQ63_RS34435 ENOG4105C26 Dehydrogenase HYQ63_RS34460 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HYQ63_RS34475 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HYQ63_RS34485 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HYQ63_RS34490 ENOG41084BS 50S ribosomal protein L35 HYQ63_RS34495 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HYQ63_RS34500 ENOG4108RWN rrna methyltransferase HYQ63_RS34505 ENOG4105BZU Histidine kinase HYQ63_RS34510 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HYQ63_RS34515 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HYQ63_RS34530 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HYQ63_RS34540 ENOG4105KT7 mgtC SapB transporter HYQ63_RS34555 ENOG4105F32 YngK protein HYQ63_RS34565 ENOG4105T38 integral membrane protein HYQ63_RS34570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYQ63_RS34585 ENOG4105CHP RNA polymerase HYQ63_RS34600 ENOG4105D29 Helix-turn-helix type 11 domain protein HYQ63_RS34605 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HYQ63_RS34610 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HYQ63_RS34615 ENOG4105CAS nag kinase HYQ63_RS34620 ENOG4105C8Y Acetylornithine aminotransferase HYQ63_RS34625 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HYQ63_RS34630 ENOG4105C09 Bile acid HYQ63_RS34715 ENOG4105CHR reductase HYQ63_RS34730 ENOG4105CDH Citrulline--aspartate ligase HYQ63_RS34735 ENOG4105CH7 arginosuccinase HYQ63_RS34750 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS34785 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS34790 ENOG4108UMI ABC transporter, permease HYQ63_RS34795 ENOG4105D01 (LipO)protein HYQ63_RS34810 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HYQ63_RS34815 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HYQ63_RS34865 ENOG4105CRQ synthase (Component I) HYQ63_RS34870 ENOG4105F0I Aminotransferase HYQ63_RS34900 ENOG4105KF0 sporulation and cell division protein, SsgA HYQ63_RS34915 ENOG4107VUR extracellular solute-binding protein HYQ63_RS34920 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HYQ63_RS34925 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HYQ63_RS34935 ENOG4105EKC HYQ63_RS34955 ENOG4108JDX DNA polymerase iii, epsilon subunit HYQ63_RS34970 ENOG4105C22 threonyL-tRNA synthetase HYQ63_RS34985 ENOG4108KQ5 Integrase catalytic subunit HYQ63_RS35005 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HYQ63_RS35010 ENOG4105E2K Glycosyl transferase (Group 1 HYQ63_RS35020 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HYQ63_RS35025 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HYQ63_RS35030 ENOG4105CDY transcriptional regulatory protein HYQ63_RS35035 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HYQ63_RS35040 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HYQ63_RS35045 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HYQ63_RS35055 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HYQ63_RS35060 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HYQ63_RS35065 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HYQ63_RS35070 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HYQ63_RS35075 ENOG4105C99 atpase involved in dna repair HYQ63_RS35080 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HYQ63_RS35090 ENOG4105CUT histidyl-tRNA synthetase HYQ63_RS35110 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HYQ63_RS35125 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HYQ63_RS35130 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HYQ63_RS35140 ENOG4105E2X shikimate dehydrogenase HYQ63_RS35145 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HYQ63_RS35150 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HYQ63_RS35155 ENOG4105D49 3-dehydroquinate synthase HYQ63_RS35165 ENOG4105DC7 peptidase M24 HYQ63_RS35170 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HYQ63_RS35175 ENOG410803B Involved in the transcription termination process (By similarity) HYQ63_RS35185 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HYQ63_RS35190 ENOG4105CXT aspartate transcarbamylase HYQ63_RS35195 ENOG4105CD3 dihydroorotase HYQ63_RS35205 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HYQ63_RS35210 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HYQ63_RS35215 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HYQ63_RS35220 ENOG4105SKN orotidine 5''-phosphate decarboxylase HYQ63_RS35245 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HYQ63_RS35260 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HYQ63_RS35275 ENOG4105E9K Isocitrate dehydrogenase HYQ63_RS35285 ENOG4105DJV ribulose-phosphate 3-epimerase HYQ63_RS35290 ENOG4105DKT Transcriptional regulator HYQ63_RS35310 ENOG4105CUB amino acid HYQ63_RS35345 ENOG4105C2W permease HYQ63_RS35380 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HYQ63_RS35385 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HYQ63_RS35390 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HYQ63_RS35395 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HYQ63_RS35475 ENOG4108YV4 Universal stress protein HYQ63_RS35480 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HYQ63_RS35495 ENOG41080XP Cbs domain HYQ63_RS35505 ENOG4105VPX protein, conserved in bacteria HYQ63_RS35510 ENOG4105C59 p-type ATPase HYQ63_RS35540 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) HYQ63_RS35585 ENOG4105CD5 CoA-binding domain protein HYQ63_RS35600 ENOG4108JB9 formate dehydrogenase HYQ63_RS35605 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HYQ63_RS35655 ENOG4105C3M thioredoxin reductase HYQ63_RS35680 ENOG4105H3G oxidoreductase HYQ63_RS35710 ENOG41082BM Transcriptional regulator, arsr family HYQ63_RS35715 ENOG4105H3G oxidoreductase HYQ63_RS35740 ENOG4105EYW Ion transport protein HYQ63_RS35745 ENOG4107ZYR domain protein HYQ63_RS35750 ENOG4105CZN Potassium uptake protein HYQ63_RS35770 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HYQ63_RS35785 ENOG4105CIG ABC transporter HYQ63_RS35975 ENOG4106DF6 pertussis toxin subunit 1 HYQ63_RS36055 ENOG4105CJ1 ABC, transporter HYQ63_RS36070 ENOG4105EN6 Membrane HYQ63_RS36090 ENOG4105K4I Scp-like extracellular HYQ63_RS36095 ENOG4105C85 amino acid HYQ63_RS36110 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HYQ63_RS36150 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HYQ63_RS36155 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HYQ63_RS36165 ENOG4105K64 Glycosyl transferase, family 2 HYQ63_RS36175 ENOG4105EQQ protein containing aminopeptidase domain HYQ63_RS36190 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HYQ63_RS36200 ENOG4105CPK Glycosyl transferase (Group 1 HYQ63_RS36220 ENOG4107RRD Dehydrogenase HYQ63_RS36225 ENOG4105CAQ asparagine synthetase HYQ63_RS36245 ENOG4105C6Y Udp-glucose 6-dehydrogenase HYQ63_RS36250 ENOG4105D3Q Sugar transferase HYQ63_RS36290 ENOG4105YA8 Transcriptional regulator HYQ63_RS36340 ENOG4107SQU synthase HYQ63_RS36355 ENOG4105C0W non-ribosomal peptide synthetase HYQ63_RS36360 ENOG4107QKG PfaD family HYQ63_RS36365 ENOG4106A3M Cytochrome p-450 HYQ63_RS36390 ENOG4105E1F short-chain dehydrogenase reductase HYQ63_RS36395 ENOG4108TKH Nitroreductase HYQ63_RS36410 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase HYQ63_RS36430 ENOG4105EYF MMPL domain protein HYQ63_RS36500 ENOG4108M0I Transcriptional regulator HYQ63_RS36535 ENOG4108IND Tetr family transcriptional regulator HYQ63_RS36540 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HYQ63_RS36545 ENOG4108KQ5 Integrase catalytic subunit HYQ63_RS36570 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYQ63_RS36600 ENOG4105MSB protein, conserved in bacteria HYQ63_RS36605 ENOG4105MSB protein, conserved in bacteria HYQ63_RS36630 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HYQ63_RS36635 ENOG4105ECY inositol monophosphatase HYQ63_RS36645 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS36660 ENOG4108HMN Caspase domain HYQ63_RS36750 ENOG4105CPC Aldo Keto reductase HYQ63_RS36770 ENOG4105W5Z HYQ63_RS36795 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HYQ63_RS36800 ENOG4107RTG Major Facilitator superfamily HYQ63_RS36810 ENOG4105C6Z Gluconate HYQ63_RS36815 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HYQ63_RS36820 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HYQ63_RS36830 ENOG4107258 Transcriptional regulator HYQ63_RS36860 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HYQ63_RS36870 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HYQ63_RS36880 ENOG4105CNV Aldolase HYQ63_RS36885 ENOG4108JQ1 Dehydrogenase HYQ63_RS36890 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HYQ63_RS36900 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HYQ63_RS36910 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS36925 ENOG4105DRS transport system, permease HYQ63_RS36980 ENOG4105EMU Dehydrogenase HYQ63_RS36995 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS37025 ENOG4107P5I polyketide synthase HYQ63_RS37055 ENOG4105C7F AcnD-accessory protein PrpF HYQ63_RS37060 ENOG4107QJT sodium dicarboxylate symporter HYQ63_RS37065 ENOG4105YVS arsR family transcriptional regulator HYQ63_RS37080 ENOG4105N14 lysine exporter protein LysE YggA HYQ63_RS37095 ENOG4107QNK )-transporter HYQ63_RS37120 ENOG4107S9F NmrA family HYQ63_RS37125 ENOG4105DU0 nucleoside hydrolase HYQ63_RS37150 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HYQ63_RS37200 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HYQ63_RS37205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HYQ63_RS37240 ENOG41061GT Aldolase HYQ63_RS37245 ENOG4106M32 3-dehydroquinate synthase HYQ63_RS37255 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HYQ63_RS37280 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HYQ63_RS37285 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HYQ63_RS37290 ENOG4107T4Z adenosine kinase HYQ63_RS37330 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HYQ63_RS37335 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HYQ63_RS37345 ENOG4106KE4 Dehydrogenase HYQ63_RS37350 ENOG4105KVH Transcriptional regulator HYQ63_RS37355 ENOG4105CPC Aldo Keto reductase HYQ63_RS37385 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 HYQ63_RS37395 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HYQ63_RS37400 ENOG4105C5H ABC transporter HYQ63_RS37405 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS37410 ENOG410846T CoA-transferase family III HYQ63_RS37415 ENOG4106NZI LysR family Transcriptional regulator HYQ63_RS37425 ENOG4105DQ4 alcohol dehydrogenase HYQ63_RS37430 ENOG4105EBR Carboxylesterase HYQ63_RS37450 ENOG4108D32 Methyltransferase HYQ63_RS37500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS37525 ENOG4105FDP GntR family transcriptional regulator HYQ63_RS37530 ENOG4108KD5 ADP-ribosylation crystallin J1 HYQ63_RS37540 ENOG4108TFM Kinase, PfkB family HYQ63_RS37570 ENOG410870F Cyclic nucleotide-binding protein HYQ63_RS37580 ENOG4105DBV ornithine carbamoyltransferase HYQ63_RS37605 ENOG4105WQT MbtH domain protein HYQ63_RS37610 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HYQ63_RS37645 ENOG4105C7S Dehydrogenase HYQ63_RS37655 ENOG4107R0V Pyruvate dehydrogenase HYQ63_RS37680 ENOG4105C57 major facilitator superfamily HYQ63_RS37690 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS37695 ENOG4105BZU Histidine kinase HYQ63_RS37730 ENOG4107W6X Transcriptional regulator HYQ63_RS37735 ENOG4105C2J ABC transporter HYQ63_RS37740 ENOG4108HWW ABC transporter HYQ63_RS37750 ENOG4105CXK mandelate racemase muconate lactonizing HYQ63_RS37760 ENOG4105CSH Transporter HYQ63_RS37795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS37800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYQ63_RS37835 ENOG4105CSH Transporter HYQ63_RS37840 ENOG4106448 streptomycin biosynthesis protein strI HYQ63_RS37850 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HYQ63_RS37870 ENOG4105DEN Luciferase family HYQ63_RS37875 ENOG4108J59 Extracellular solute-binding protein, family 5 HYQ63_RS37885 ENOG4105EEM helicase HYQ63_RS37890 ENOG4105R1U AraC Family Transcriptional Regulator HYQ63_RS37895 ENOG4105EU0 Major facilitator Superfamily HYQ63_RS37900 ENOG4105VMP Transcriptional regulator HYQ63_RS37930 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HYQ63_RS37960 ENOG4108HMN Caspase domain HYQ63_RS37985 ENOG4107S46 esterase, PHB depolymerase HYQ63_RS38000 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HYQ63_RS38005 ENOG4108JA1 polyketide synthase HYQ63_RS38035 ENOG4105C57 major facilitator superfamily HYQ63_RS38060 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS38120 ENOG4108JA1 polyketide synthase HYQ63_RS38140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HYQ63_RS38145 ENOG4107QNK )-transporter HYQ63_RS38150 ENOG41060NJ transcriptional regulator HYQ63_RS38165 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HYQ63_RS38195 ENOG4105IE8 Alpha-ketoglutarate permease HYQ63_RS38200 ENOG4105E98 transcriptional regulator DeoR family HYQ63_RS38215 ENOG4105CMG Carbohydrate kinase HYQ63_RS38220 ENOG4105CMT Dihydroxyacetone kinase HYQ63_RS38225 ENOG4107YVI ribose 5-phosphate isomerase HYQ63_RS38235 ENOG4105CUC YeeE YedE family protein HYQ63_RS38290 ENOG41086D8 Transcriptional regulator HYQ63_RS38295 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HYQ63_RS38315 ENOG4105CEY Amp-dependent synthetase and ligase HYQ63_RS38330 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HYQ63_RS38340 ENOG4105CPC Aldo Keto reductase HYQ63_RS38350 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HYQ63_RS38370 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HYQ63_RS38375 ENOG4105CHR reductase HYQ63_RS38395 ENOG4108SGK Tetr family transcriptional regulator HYQ63_RS38400 ENOG4105CPC Aldo Keto reductase HYQ63_RS38430 ENOG4105CSH Transporter HYQ63_RS38445 ENOG4105GWZ Roadblock lc7 family protein HYQ63_RS38470 ENOG4107QN1 sodium solute HYQ63_RS38475 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS38485 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HYQ63_RS38490 ENOG4107YY3 extracellular solute-binding protein family 1 HYQ63_RS38495 ENOG4105C4C beta-galactosidase HYQ63_RS38505 ENOG4105E08 Glycoside hydrolase, family 9 HYQ63_RS38520 ENOG4108YYC ycei family HYQ63_RS38525 ENOG4107VHA regulatoR HYQ63_RS38535 ENOG4105D82 Glutamate dehydrogenase HYQ63_RS38560 ENOG4105C26 Dehydrogenase HYQ63_RS38580 ENOG4105EBR Carboxylesterase HYQ63_RS38590 ENOG4105EQ2 LysR family Transcriptional regulator HYQ63_RS38600 ENOG4105D9G High-affinity HYQ63_RS38605 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HYQ63_RS38615 ENOG4107QM5 aconitate hydratase HYQ63_RS38625 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HYQ63_RS38630 ENOG4105PDP Short chain dehydrogenase HYQ63_RS38635 ENOG4107RSM transcriptional regulator HYQ63_RS38640 ENOG4105DTQ mandelate racemase muconate lactonizing HYQ63_RS38645 ENOG4108QMY dioxygenase HYQ63_RS38665 ENOG4106R7G Glycoside hydrolase family 5 HYQ63_RS38680 ENOG4108FUF Transcriptional regulator, IclR family HYQ63_RS38685 ENOG4105CSH Transporter HYQ63_RS38700 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HYQ63_RS38710 ENOG4105E3J oxidoreductase HYQ63_RS38715 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HYQ63_RS38725 ENOG4105E7U AraC family transcriptional regulator HYQ63_RS38735 ENOG4105CPN adenine deaminase HYQ63_RS38740 ENOG4105CHJ isochorismatase hydrolase HYQ63_RS38745 ENOG4105XPP Protein of unknown function (DUF1275) HYQ63_RS38760 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HYQ63_RS38790 ENOG4105CQB FAD linked oxidase domain protein HYQ63_RS38800 ENOG4105CHR reductase HYQ63_RS38840 ENOG4105E4I Glycoside hydrolase family 28 HYQ63_RS38855 ENOG4108PJD permease HYQ63_RS38860 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HYQ63_RS38875 ENOG410880H cysteine synthase HYQ63_RS38885 ENOG4105EMU Dehydrogenase HYQ63_RS38895 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HYQ63_RS38905 ENOG4105C7K acetolactate synthase HYQ63_RS38910 ENOG4105CSH Transporter HYQ63_RS38950 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS38970 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS38975 ENOG4105DRS transport system, permease HYQ63_RS38980 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HYQ63_RS39005 ENOG4108QBF Transcriptional regulator HYQ63_RS39030 ENOG4108KQ5 Integrase catalytic subunit HYQ63_RS39045 ENOG4105C3U ABC transporter HYQ63_RS39055 ENOG4105DEF Extracellular solute-binding protein, family 5 HYQ63_RS39065 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HYQ63_RS39085 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HYQ63_RS39090 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HYQ63_RS39095 ENOG4105IKQ hydratase HYQ63_RS39105 ENOG4105CAY ferredoxin--nadp reductase HYQ63_RS39115 ENOG4108M9J MaoC like domain protein HYQ63_RS39160 ENOG4105CPQ Dehydrogenase HYQ63_RS39170 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HYQ63_RS39185 ENOG4108Q50 Histidine kinase HYQ63_RS39195 ENOG4105BZP glycoside hydrolase 15-related HYQ63_RS39200 ENOG4107R34 abc transporter permease protein HYQ63_RS39205 ENOG4105BZU Histidine kinase HYQ63_RS39210 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS39220 ENOG4108JJ8 (ABC) transporter HYQ63_RS39225 ENOG4108JJ9 ABC, transporter HYQ63_RS39240 ENOG4105C4M (Ubiquinol oxidase) subunit I HYQ63_RS39255 ENOG4105C01 Dihydroxy-acid dehydratase HYQ63_RS39260 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HYQ63_RS39270 ENOG4107QTZ amino acid HYQ63_RS39275 ENOG41066YJ Beta-lactamase HYQ63_RS39285 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS39300 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HYQ63_RS39310 ENOG4108MBX Secretion Protein HYQ63_RS39315 ENOG4108JJA ABC, transporter HYQ63_RS39330 ENOG4105BZU Histidine kinase HYQ63_RS39335 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS39360 ENOG4108HWW ABC transporter HYQ63_RS39365 ENOG4105C2J ABC transporter HYQ63_RS39370 ENOG4105DFW ABC transporter HYQ63_RS39405 ENOG4105EBR Carboxylesterase HYQ63_RS39420 ENOG4105CNA YD repeat protein HYQ63_RS39430 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HYQ63_RS39460 ENOG4105K4I Scp-like extracellular HYQ63_RS39510 ENOG4105ENE Histidine kinase HYQ63_RS39515 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS39525 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HYQ63_RS39535 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HYQ63_RS39555 ENOG4105CUB amino acid HYQ63_RS39575 ENOG4105DTQ mandelate racemase muconate lactonizing HYQ63_RS39585 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HYQ63_RS39590 ENOG4108K8U Glycerol operon regulatory protein HYQ63_RS39615 ENOG4105C6Z Gluconate HYQ63_RS39650 ENOG4105CI2 imidazolone-5-propionate hydrolase HYQ63_RS39655 ENOG4105CFC Transporter HYQ63_RS39660 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HYQ63_RS39670 ENOG4107TT2 Auxin Efflux Carrier HYQ63_RS39675 ENOG4105C6K Malic enzyme HYQ63_RS39680 ENOG4105DHU Bile acid HYQ63_RS39685 ENOG4105CR4 methylisocitrate lyase HYQ63_RS39690 ENOG4108XNA Gas vesicle HYQ63_RS39695 ENOG4107ETC gas vesicle protein HYQ63_RS39705 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HYQ63_RS39720 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HYQ63_RS39730 ENOG4105MKU Transcriptional regulator HYQ63_RS39770 ENOG4105DQ4 alcohol dehydrogenase HYQ63_RS39775 ENOG4105CSH Transporter HYQ63_RS39780 ENOG4105DEI Mannitol dehydrogenase HYQ63_RS39790 ENOG4105C5I Dehydrogenase HYQ63_RS39800 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HYQ63_RS39815 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HYQ63_RS39830 ENOG4107VFR oxidoreductase HYQ63_RS39850 ENOG4105CTU Proline racemase HYQ63_RS39855 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HYQ63_RS39865 ENOG4105CMG Carbohydrate kinase HYQ63_RS39875 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS39890 ENOG4105D64 Mechanosensitive ion channel HYQ63_RS39900 ENOG4105CG3 alpha amylase, catalytic region HYQ63_RS39910 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS39935 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HYQ63_RS39955 ENOG4105G9B Transcriptional regulator HYQ63_RS39965 ENOG4107QN1 sodium solute HYQ63_RS39980 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HYQ63_RS40010 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HYQ63_RS40025 ENOG4107R33 ppx gppa phosphatase HYQ63_RS40035 ENOG4107RT3 EamA-like transporter family HYQ63_RS40050 ENOG4106SPC secreted protein HYQ63_RS40060 ENOG4105E0A ABC, transporter HYQ63_RS40065 ENOG4105EHG Permease protein HYQ63_RS40095 ENOG4105CNT hydrolase family 2 HYQ63_RS40110 ENOG4105PGM cation diffusion facilitator family transporter HYQ63_RS40135 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HYQ63_RS40140 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HYQ63_RS40145 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HYQ63_RS40150 ENOG4105C7W Xanthine dehydrogenase HYQ63_RS40170 ENOG4108TGC Acyltransferase HYQ63_RS40175 ENOG4105CMT Dihydroxyacetone kinase HYQ63_RS40180 ENOG4105CMT Dihydroxyacetone kinase HYQ63_RS40185 ENOG4105K6H D-cysteine desulfhydrase HYQ63_RS40195 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HYQ63_RS40205 ENOG4105C5I Dehydrogenase HYQ63_RS40210 ENOG4105C54 Major Facilitator superfamily HYQ63_RS40235 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HYQ63_RS40240 ENOG4108VQT Alpha beta hydrolase fold protein HYQ63_RS40255 ENOG4108W6C Dehydrogenase HYQ63_RS40265 ENOG4108ZJ4 polysaccharide deacetylase HYQ63_RS40275 ENOG4105D74 hydrolase HYQ63_RS40295 ENOG4105E2B Taurine dioxygenase HYQ63_RS40305 ENOG4105DND Transcriptional regulator HYQ63_RS40315 ENOG41061H0 Monooxygenase HYQ63_RS40320 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS40330 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HYQ63_RS40340 ENOG4105CJ3 phosphate transporter HYQ63_RS40350 ENOG4105DDN Pentapeptide repeat-containing protein HYQ63_RS40370 ENOG4105F8D glycoside hydrolase family 4 HYQ63_RS40395 ENOG4105CNT hydrolase family 2 HYQ63_RS40415 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS40455 ENOG4106NZI LysR family Transcriptional regulator HYQ63_RS40465 ENOG4107258 Transcriptional regulator HYQ63_RS40470 ENOG4105F76 Sarcosine oxidase HYQ63_RS40475 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase HYQ63_RS40485 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HYQ63_RS40500 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HYQ63_RS40515 ENOG4107SET aldo keto reductase HYQ63_RS40525 ENOG4105CJP fad dependent oxidoreductase HYQ63_RS40530 ENOG4105E98 transcriptional regulator DeoR family HYQ63_RS40535 ENOG4107T3P ABC, transporter HYQ63_RS40580 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HYQ63_RS40630 ENOG41090CE integral membrane protein HYQ63_RS40690 ENOG4105DD7 kinase (PfkB family HYQ63_RS40695 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HYQ63_RS40770 ENOG4108KPJ rna polymerase sigma factor HYQ63_RS40775 ENOG4105DUM transcriptional regulator, lysR family HYQ63_RS40785 ENOG4105CSH Transporter HYQ63_RS40795 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HYQ63_RS40805 ENOG4105JQZ Methyltransferase HYQ63_RS40925 ENOG4108222 arsenate reductase HYQ63_RS40935 ENOG4105DJB Major Facilitator Superfamily HYQ63_RS40945 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYQ63_RS41005 ENOG4105CND Glycosyl transferase, family 2 HYQ63_RS41030 ENOG4105C7W Xanthine dehydrogenase HYQ63_RS41035 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HYQ63_RS41040 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HYQ63_RS41055 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HYQ63_RS41110 ENOG4105JSC dimethylmenaquinone methyltransferase HYQ63_RS41115 ENOG4105CSH Transporter HYQ63_RS41120 ENOG4105E7W lamb ycsf family protein HYQ63_RS41135 ENOG4107FW0 short-chain dehydrogenase reductase HYQ63_RS41150 ENOG4105CBC glutamate synthase HYQ63_RS41160 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HYQ63_RS41185 ENOG4105DQE DNA ligase HYQ63_RS41205 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS41210 ENOG41089GP Oxidoreductase domain protein HYQ63_RS41215 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HYQ63_RS41220 ENOG4105EE0 oxidoreductase HYQ63_RS41230 ENOG4108HMN Caspase domain HYQ63_RS41255 ENOG4105E6M Sulphatase-modifying factor protein HYQ63_RS41260 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HYQ63_RS41265 ENOG4105CHR reductase HYQ63_RS41285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS41295 ENOG4105DEF Extracellular solute-binding protein, family 5 HYQ63_RS41305 ENOG4105EUF amidase EC 3.5.1.4 HYQ63_RS41330 ENOG4108VGI doxx family HYQ63_RS41335 ENOG4105C57 major facilitator superfamily HYQ63_RS41360 ENOG4105K5B UPF0225 protein HYQ63_RS41365 ENOG4105CPQ Dehydrogenase HYQ63_RS41370 ENOG4105DJB Major Facilitator Superfamily HYQ63_RS41375 ENOG4105DEI Mannitol dehydrogenase HYQ63_RS41400 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HYQ63_RS41405 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HYQ63_RS41420 ENOG4105CIR epoxide hydrolase HYQ63_RS41440 ENOG4105CFC Transporter HYQ63_RS41500 ENOG4108JPW Aminotransferase HYQ63_RS41515 ENOG4105K4I Scp-like extracellular HYQ63_RS41530 ENOG4105CUB amino acid HYQ63_RS41545 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HYQ63_RS41550 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HYQ63_RS41570 ENOG4105C7W Xanthine dehydrogenase HYQ63_RS41590 ENOG4105CV8 reductase HYQ63_RS41605 ENOG4105C2J ABC transporter HYQ63_RS41645 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS41715 ENOG4107RCI amp-dependent synthetase and ligase HYQ63_RS41720 ENOG4105VPX protein, conserved in bacteria HYQ63_RS41740 ENOG4105ESN nucleotide-binding protein HYQ63_RS41745 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HYQ63_RS41755 ENOG4105JZI cytochrome P450 HYQ63_RS41780 ENOG4105DZ2 Transcriptional regulator HYQ63_RS41785 ENOG4105C9B Cysteine desulfurase HYQ63_RS41790 ENOG4108JQ7 (ABC) transporter HYQ63_RS41800 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS41815 ENOG4105NRA 50s ribosomal protein l31 type b HYQ63_RS41825 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HYQ63_RS41830 ENOG4108PJD permease HYQ63_RS41860 ENOG4105C9B Cysteine desulfurase HYQ63_RS41865 ENOG4105C6T cysteine synthase HYQ63_RS41935 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS41940 ENOG4105D2S major facilitator superfamily HYQ63_RS41945 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYQ63_RS42005 ENOG4105C26 Dehydrogenase HYQ63_RS42020 ENOG4105DG4 malate L-lactate dehydrogenase HYQ63_RS42035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYQ63_RS42040 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HYQ63_RS42085 ENOG4105EA8 2-Nitropropane dioxygenase HYQ63_RS42100 ENOG41060WC Enoyl-CoA hydratase HYQ63_RS42125 ENOG41067HS methyltransferase HYQ63_RS42130 ENOG4108V75 Glutamine amidotransferase HYQ63_RS42135 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HYQ63_RS42145 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HYQ63_RS42150 ENOG4105D2B acyl-CoA dehydrogenase HYQ63_RS42155 ENOG4105D2B acyl-CoA dehydrogenase HYQ63_RS42165 ENOG4105ESN nucleotide-binding protein HYQ63_RS42170 ENOG4105ESN nucleotide-binding protein HYQ63_RS42190 ENOG4105DKQ ROK family HYQ63_RS42210 ENOG4107XWB Zinc finger, swim domain protein HYQ63_RS42215 ENOG4105C0D helicase HYQ63_RS42260 ENOG4105GWZ Roadblock lc7 family protein HYQ63_RS42270 ENOG4105C29 acyl-CoA thioesterase HYQ63_RS42285 ENOG4105BZ1 (ABC) transporter HYQ63_RS42290 ENOG4105BZ1 (ABC) transporter HYQ63_RS42310 ENOG4105BZ1 (ABC) transporter HYQ63_RS42320 ENOG4105I82 acetyl xylan esterase HYQ63_RS42335 ENOG4105CDA abc transporter atp-binding protein HYQ63_RS42340 ENOG4105EAD ABC transporter HYQ63_RS42345 ENOG4106PMH Extracellular solute-binding protein family 3 HYQ63_RS42370 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HYQ63_RS42385 ENOG4105CPC Aldo Keto reductase HYQ63_RS42450 ENOG4105C7W Xanthine dehydrogenase HYQ63_RS42455 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HYQ63_RS42460 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HYQ63_RS42470 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HYQ63_RS42485 ENOG4105CPQ Dehydrogenase HYQ63_RS42490 ENOG4105CNN ABC, transporter HYQ63_RS42495 ENOG4108F37 ATP-binding component of a transport system HYQ63_RS42500 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HYQ63_RS42505 ENOG4105ETE Transcriptional regulator (LacI family HYQ63_RS42520 ENOG4105CNT hydrolase family 2 HYQ63_RS42525 ENOG4105DRS transport system, permease HYQ63_RS42530 ENOG410769Z extracellular solute-binding protein family 1 HYQ63_RS42540 ENOG4108R85 Short chain dehydrogenase HYQ63_RS42545 ENOG4105DRR Transcriptional regulator, GntR family HYQ63_RS42560 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HYQ63_RS42570 ENOG4108QMY dioxygenase HYQ63_RS42580 ENOG4105EYF MMPL domain protein HYQ63_RS42585 ENOG4105BZU Histidine kinase HYQ63_RS42590 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS42610 ENOG41080HT Transcriptional regulator, arsr family HYQ63_RS42615 ENOG4105CKI cobalamin synthesis protein HYQ63_RS42620 ENOG41068HZ 50S ribosomal protein L32 HYQ63_RS42625 ENOG4106A3M Cytochrome p-450 HYQ63_RS42645 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HYQ63_RS42650 ENOG4105FQP Beta-lactamase HYQ63_RS42655 ENOG4105C5Q Transcriptional regulator HYQ63_RS42660 ENOG4105CHR reductase HYQ63_RS42705 ENOG4105J7D transcriptional regulator HYQ63_RS42715 ENOG4105CPQ Dehydrogenase HYQ63_RS42745 ENOG4107SET aldo keto reductase HYQ63_RS42790 ENOG4105DCG PHP domain protein HYQ63_RS42795 ENOG4108YYC ycei family HYQ63_RS42800 ENOG4105CGS Alpha-glucosidase HYQ63_RS42820 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS42825 ENOG4105BZU Histidine kinase HYQ63_RS42845 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HYQ63_RS42850 ENOG41081JD Transcriptional regulator HYQ63_RS42880 ENOG41068SY HYQ63_RS42885 ENOG4105CHF Glutathione S-transferase HYQ63_RS42890 ENOG4107EFR Flavocytochrome c HYQ63_RS42895 ENOG4108R85 Short chain dehydrogenase HYQ63_RS42900 ENOG4105CSH Transporter HYQ63_RS42915 ENOG4105D2B acyl-CoA dehydrogenase HYQ63_RS42920 ENOG41060WC Enoyl-CoA hydratase HYQ63_RS42935 ENOG4105CC9 acyl-Coa dehydrogenase HYQ63_RS42945 ENOG4105C1G acyl-Coa dehydrogenase HYQ63_RS42950 ENOG4105CHR reductase HYQ63_RS42955 ENOG4105CHR reductase HYQ63_RS42960 ENOG4105CGU Enoyl-CoA hydratase HYQ63_RS42990 ENOG4105C5X domain protein HYQ63_RS42995 ENOG4105D9P serine threonine protein kinase HYQ63_RS43185 ENOG4107V2S Transcriptional regulator HYQ63_RS43200 ENOG4105BZ1 (ABC) transporter HYQ63_RS43205 ENOG4105BZ1 (ABC) transporter HYQ63_RS43210 ENOG4105EUJ GTP cyclohydrolase i HYQ63_RS43220 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HYQ63_RS43245 ENOG4105ESN nucleotide-binding protein HYQ63_RS43280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYQ63_RS43330 ENOG4105WH1 Two component transcriptional regulator luxr family HYQ63_RS43355 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HYQ63_RS43395 ENOG4106F1P AAA ATPase, central domain protein HYQ63_RS43400 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HYQ63_RS43405 ENOG4105EC2 ftsk spoIIIe HYQ63_RS43490 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HYQ63_RS43500 ENOG4105ENX hydrolase HYQ63_RS43510 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HYQ63_RS43550 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HYQ63_RS43635 ENOG4107EEY synthase HYQ63_RS43795 ENOG4108KQ5 Integrase catalytic subunit