locus-tag	class	description
HYQ63_RS00025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYQ63_RS00040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYQ63_RS00150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYQ63_RS00160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYQ63_RS00215	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYQ63_RS00235	COG3591	Belongs to the peptidase S1B family
HYQ63_RS00235	COG1864	DNA RNA non-specific endonuclease
HYQ63_RS00270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYQ63_RS00415	COG0584	glycerophosphoryl diester phosphodiesterase
HYQ63_RS00420	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS00475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYQ63_RS00485	COG1597	lipid kinase activity
HYQ63_RS00530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYQ63_RS00535	COG0440	acetolactate synthase activity
HYQ63_RS00580	COG0076	glutamate decarboxylase activity
HYQ63_RS00600	COG3903	Transcriptional regulator
HYQ63_RS00600	COG3629	intracellular signal transduction
HYQ63_RS00695	COG2801	Transposase and inactivated derivatives
HYQ63_RS00700	COG2801	Transposase and inactivated derivatives
HYQ63_RS00710	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYQ63_RS00845	COG2264	protein methyltransferase activity
HYQ63_RS00850	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS00895	COG2197	response regulator
HYQ63_RS00900	COG4585	Histidine kinase
HYQ63_RS00910	COG2124	cytochrome p450
HYQ63_RS00910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HYQ63_RS00920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYQ63_RS00960	COG1132	(ABC) transporter
HYQ63_RS00985	COG0604	alcohol dehydrogenase
HYQ63_RS01140	COG1819	glycosyl
HYQ63_RS01145	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HYQ63_RS01170	COG1819	glycosyl
HYQ63_RS01175	COG3629	intracellular signal transduction
HYQ63_RS01180	COG1131	(ABC) transporter
HYQ63_RS01195	COG3321	synthase
HYQ63_RS01195	COG0604	alcohol dehydrogenase
HYQ63_RS01195	COG3321	synthase
HYQ63_RS01195	COG0604	alcohol dehydrogenase
HYQ63_RS01240	COG1349	DNA-binding transcription factor activity
HYQ63_RS01275	COG0366	Alpha amylase catalytic
HYQ63_RS01280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYQ63_RS01285	COG0110	maltose O-acetyltransferase activity
HYQ63_RS01295	COG2345	Transcriptional regulator
HYQ63_RS01310	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS01325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYQ63_RS01345	COG2197	response regulator
HYQ63_RS01400	COG0515	serine threonine protein kinase
HYQ63_RS01450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYQ63_RS01455	COG2186	Transcriptional regulator
HYQ63_RS01480	COG2814	Major facilitator Superfamily
HYQ63_RS01490	COG0151	Belongs to the GarS family
HYQ63_RS01510	COG2801	Transposase and inactivated derivatives
HYQ63_RS01510	COG3415	Transposase
HYQ63_RS01515	COG3293	Transposase
HYQ63_RS01540	COG2186	Transcriptional regulator
HYQ63_RS01545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYQ63_RS01550	COG3622	Belongs to the hyi family
HYQ63_RS01555	COG2271	Major facilitator Superfamily
HYQ63_RS01560	COG0235	Class ii aldolase
HYQ63_RS01565	COG3395	kinase activity
HYQ63_RS01570	COG2084	Dehydrogenase
HYQ63_RS01600	COG2197	response regulator
HYQ63_RS01610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYQ63_RS01615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYQ63_RS01620	COG2080	2 iron, 2 sulfur cluster binding
HYQ63_RS01630	COG2801	Transposase and inactivated derivatives
HYQ63_RS01630	COG3415	Transposase
HYQ63_RS01645	COG1982	Orn Lys Arg decarboxylase major
HYQ63_RS01680	COG4106	trans-aconitate 2-methyltransferase activity
HYQ63_RS01685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYQ63_RS01690	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HYQ63_RS01725	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS01730	COG3958	Transketolase
HYQ63_RS01735	COG3959	Transketolase, thiamine diphosphate binding domain
HYQ63_RS01740	COG0477	Major facilitator Superfamily
HYQ63_RS01760	COG3250	beta-galactosidase activity
HYQ63_RS01765	COG2814	Major facilitator Superfamily
HYQ63_RS01770	COG3250	beta-galactosidase activity
HYQ63_RS01785	COG1414	Transcriptional regulator
HYQ63_RS01790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYQ63_RS01845	COG3485	protocatechuate 3,4-dioxygenase
HYQ63_RS01850	COG1454	alcohol dehydrogenase
HYQ63_RS01855	COG2124	cytochrome p450
HYQ63_RS01865	COG1414	Transcriptional regulator
HYQ63_RS01880	COG0535	radical SAM domain protein
HYQ63_RS01895	COG1301	dicarboxylic acid transport
HYQ63_RS01910	COG0583	DNA-binding transcription factor activity
HYQ63_RS01925	COG2319	Wd-40 repeat
HYQ63_RS01925	COG4249	Peptidase C14 caspase catalytic subunit p20
HYQ63_RS01950	COG0477	Major facilitator Superfamily
HYQ63_RS01975	COG1760	l-serine dehydratase
HYQ63_RS01985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYQ63_RS02005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYQ63_RS02025	COG4638	Rieske (2fe-2S)
HYQ63_RS02040	COG2226	methyltransferase
HYQ63_RS02060	COG0477	Major facilitator Superfamily
HYQ63_RS02075	COG3835	regulator
HYQ63_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS02085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYQ63_RS02145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYQ63_RS02160	COG2271	Major facilitator Superfamily
HYQ63_RS02170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYQ63_RS02175	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS02190	COG3961	Belongs to the TPP enzyme family
HYQ63_RS02195	COG1231	oxidoreductase activity
HYQ63_RS02205	COG1472	Belongs to the glycosyl hydrolase 3 family
HYQ63_RS02215	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS02235	COG1609	Transcriptional regulator
HYQ63_RS02240	COG2267	carboxylic ester hydrolase activity
HYQ63_RS02245	COG0515	serine threonine protein kinase
HYQ63_RS02280	COG0765	amino acid transport
HYQ63_RS02290	COG0583	DNA-binding transcription factor activity
HYQ63_RS02305	COG2326	polyphosphate kinase activity
HYQ63_RS02320	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYQ63_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS02330	COG0277	FAD linked oxidase domain protein
HYQ63_RS02330	COG0247	lactate metabolic process
HYQ63_RS02340	COG0531	amino acid
HYQ63_RS02355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HYQ63_RS02370	COG2382	esterase
HYQ63_RS02375	COG1132	(ABC) transporter
HYQ63_RS02385	COG1132	(ABC) transporter
HYQ63_RS02390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYQ63_RS02395	COG1120	ATPase activity
HYQ63_RS02400	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYQ63_RS02405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYQ63_RS02410	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HYQ63_RS02420	COG1082	Xylose isomerase domain protein TIM barrel
HYQ63_RS02430	COG2814	Major facilitator Superfamily
HYQ63_RS02445	COG1609	Transcriptional regulator
HYQ63_RS02460	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYQ63_RS02465	COG0583	DNA-binding transcription factor activity
HYQ63_RS02480	COG1940	carbohydrate kinase activity
HYQ63_RS02490	COG0009	L-threonylcarbamoyladenylate synthase
HYQ63_RS02510	COG0601	transmembrane transport
HYQ63_RS02520	COG0444	Belongs to the ABC transporter superfamily
HYQ63_RS02525	COG4608	Belongs to the ABC transporter superfamily
HYQ63_RS02575	COG0747	negative chemotaxis
HYQ63_RS02585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYQ63_RS02590	COG0277	FAD linked oxidase domain protein
HYQ63_RS02595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYQ63_RS02600	COG2011	ABC-type metal ion transport system permease component
HYQ63_RS02615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS02640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS02765	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS02795	COG2267	carboxylic ester hydrolase activity
HYQ63_RS02820	COG3290	protein histidine kinase activity
HYQ63_RS02825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HYQ63_RS02830	COG2301	Belongs to the HpcH HpaI aldolase family
HYQ63_RS02835	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HYQ63_RS02840	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS02855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYQ63_RS02860	COG0583	DNA-binding transcription factor activity
HYQ63_RS02865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYQ63_RS02880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYQ63_RS02880	COG0473	3-isopropylmalate dehydrogenase activity
HYQ63_RS02890	COG0583	DNA-binding transcription factor activity
HYQ63_RS02900	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS02905	COG3321	synthase
HYQ63_RS02905	COG0604	alcohol dehydrogenase
HYQ63_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS02910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYQ63_RS02915	COG1522	sequence-specific DNA binding
HYQ63_RS02920	COG1834	amidinotransferase
HYQ63_RS02925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYQ63_RS02930	COG3224	Antibiotic biosynthesis monooxygenase
HYQ63_RS02940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYQ63_RS02950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYQ63_RS02960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYQ63_RS02975	COG2186	Transcriptional regulator
HYQ63_RS02985	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS02995	COG0477	Major facilitator Superfamily
HYQ63_RS03000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HYQ63_RS03010	COG2226	methyltransferase
HYQ63_RS03015	COG0443	Heat shock 70 kDa protein
HYQ63_RS03045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS03060	COG0596	Alpha beta hydrolase
HYQ63_RS03065	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS03070	COG1802	Transcriptional regulator
HYQ63_RS03085	COG0477	Major facilitator Superfamily
HYQ63_RS03090	COG1472	Belongs to the glycosyl hydrolase 3 family
HYQ63_RS03105	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS03120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYQ63_RS03120	COG1796	DNA polymerase
HYQ63_RS03140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HYQ63_RS03145	COG1349	DNA-binding transcription factor activity
HYQ63_RS03150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYQ63_RS03155	COG0191	fructose-bisphosphate aldolase activity
HYQ63_RS03180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYQ63_RS03200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYQ63_RS03240	COG0183	Belongs to the thiolase family
HYQ63_RS03245	COG1309	transcriptional regulator
HYQ63_RS03255	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS03260	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS03275	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS03285	COG0477	Major facilitator Superfamily
HYQ63_RS03300	COG3360	Dodecin
HYQ63_RS03310	COG3959	Transketolase, thiamine diphosphate binding domain
HYQ63_RS03315	COG1252	NADH dehydrogenase
HYQ63_RS03325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYQ63_RS03390	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HYQ63_RS03405	COG0110	maltose O-acetyltransferase activity
HYQ63_RS03450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYQ63_RS03455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYQ63_RS03465	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS03485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYQ63_RS03515	COG0477	Major facilitator Superfamily
HYQ63_RS03520	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS03525	COG2205	protein histidine kinase activity
HYQ63_RS03530	COG2358	TRAP transporter, solute receptor (TAXI family
HYQ63_RS03555	COG2205	protein histidine kinase activity
HYQ63_RS03560	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS03590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HYQ63_RS03640	COG0300	oxidoreductase activity
HYQ63_RS03650	COG0477	Major facilitator Superfamily
HYQ63_RS03675	COG2197	response regulator
HYQ63_RS03680	COG4585	Histidine kinase
HYQ63_RS03695	COG2851	Citrate transporter
HYQ63_RS03700	COG0583	DNA-binding transcription factor activity
HYQ63_RS03705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYQ63_RS03715	COG1595	DNA-templated transcription, initiation
HYQ63_RS03730	COG0386	Belongs to the glutathione peroxidase family
HYQ63_RS03740	COG2353	YceI-like domain
HYQ63_RS03830	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS03835	COG1175	transmembrane transport
HYQ63_RS03840	COG1653	transport
HYQ63_RS03845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYQ63_RS03850	COG1349	DNA-binding transcription factor activity
HYQ63_RS03855	COG1486	melibiose metabolic process
HYQ63_RS03875	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS03880	COG1063	alcohol dehydrogenase
HYQ63_RS03895	COG1349	DNA-binding transcription factor activity
HYQ63_RS03910	COG0514	ATP-dependent DNA helicase (RecQ)
HYQ63_RS03935	COG2186	Transcriptional regulator
HYQ63_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS03975	COG0765	amino acid transport
HYQ63_RS04000	COG0640	Transcriptional regulator
HYQ63_RS04055	COG1609	Transcriptional regulator
HYQ63_RS04065	COG1175	transmembrane transport
HYQ63_RS04070	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS04085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYQ63_RS04095	COG0277	FAD linked oxidase domain protein
HYQ63_RS04100	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HYQ63_RS04105	COG0517	IMP dehydrogenase activity
HYQ63_RS04105	COG0516	GMP reductase activity
HYQ63_RS04110	COG0589	response to stress
HYQ63_RS04115	COG1063	alcohol dehydrogenase
HYQ63_RS04170	COG0242	peptide deformylase activity
HYQ63_RS04190	COG1953	Uracil, thiamine, allantoin
HYQ63_RS04210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYQ63_RS04215	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS04220	COG1175	transmembrane transport
HYQ63_RS04230	COG1609	Transcriptional regulator
HYQ63_RS04280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYQ63_RS04295	COG2356	endonuclease I
HYQ63_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS04310	COG0667	Aldo Keto reductase
HYQ63_RS04315	COG4608	Belongs to the ABC transporter superfamily
HYQ63_RS04330	COG0601	transmembrane transport
HYQ63_RS04340	COG3395	kinase activity
HYQ63_RS04345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYQ63_RS04350	COG1349	DNA-binding transcription factor activity
HYQ63_RS04370	COG1191	sigma factor activity
HYQ63_RS04380	COG1793	dna ligase
HYQ63_RS04415	COG3631	Ketosteroid isomerase-related protein
HYQ63_RS04420	COG0702	epimerase
HYQ63_RS04470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYQ63_RS04475	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS04485	COG0242	peptide deformylase activity
HYQ63_RS04495	COG3442	glutamine amidotransferase
HYQ63_RS04500	COG0205	6-phosphofructokinase activity
HYQ63_RS04550	COG1309	transcriptional regulator
HYQ63_RS04565	COG0829	nickel cation binding
HYQ63_RS04570	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HYQ63_RS04580	COG0804	urea catabolic process
HYQ63_RS04585	COG0832	Belongs to the urease beta subunit family
HYQ63_RS04590	COG0831	urea catabolic process
HYQ63_RS04595	COG4935	Belongs to the peptidase S8 family
HYQ63_RS04595	COG2234	aminopeptidase activity
HYQ63_RS04605	COG0740	serine-type endopeptidase activity
HYQ63_RS04615	COG0791	NLP P60 protein
HYQ63_RS04615	COG0741	lytic transglycosylase activity
HYQ63_RS04655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYQ63_RS04660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYQ63_RS04665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HYQ63_RS04670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYQ63_RS04685	COG1136	(ABC) transporter
HYQ63_RS04685	COG0577	efflux transmembrane transporter activity
HYQ63_RS04725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYQ63_RS04730	COG3663	DNA glycosylase
HYQ63_RS04740	COG1940	carbohydrate kinase activity
HYQ63_RS04745	COG2188	Transcriptional regulator
HYQ63_RS04750	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS04780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYQ63_RS04785	COG0419	ATPase involved in DNA repair
HYQ63_RS04790	COG0420	3'-5' exonuclease activity
HYQ63_RS04805	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS04810	COG0642	Histidine kinase
HYQ63_RS04860	COG1832	CoA-binding protein
HYQ63_RS04915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYQ63_RS04925	COG1968	undecaprenyl-diphosphatase activity
HYQ63_RS04935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYQ63_RS04940	COG2072	flavoprotein involved in K transport
HYQ63_RS04945	COG0477	Major facilitator Superfamily
HYQ63_RS04980	COG3618	amidohydrolase
HYQ63_RS04990	COG1090	epimerase
HYQ63_RS04995	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYQ63_RS05005	COG1879	ABC-type sugar transport system periplasmic component
HYQ63_RS05015	COG1609	Transcriptional regulator
HYQ63_RS05035	COG2828	Protein conserved in bacteria
HYQ63_RS05040	COG0477	Major facilitator Superfamily
HYQ63_RS05040	COG2814	Major facilitator Superfamily
HYQ63_RS05065	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS05070	COG1063	alcohol dehydrogenase
HYQ63_RS05075	COG1349	DNA-binding transcription factor activity
HYQ63_RS05090	COG4221	oxidoreductase activity
HYQ63_RS05120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYQ63_RS05120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYQ63_RS05120	COG1703	isobutyryl-CoA mutase activity
HYQ63_RS05125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYQ63_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS05180	COG3971	2-oxopent-4-enoate hydratase activity
HYQ63_RS05190	COG0477	Major facilitator Superfamily
HYQ63_RS05200	COG1414	Transcriptional regulator
HYQ63_RS05235	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS05245	COG1309	transcriptional regulator
HYQ63_RS05265	COG1595	DNA-templated transcription, initiation
HYQ63_RS05275	COG1834	amidinotransferase
HYQ63_RS05290	COG0714	Associated with various cellular activities
HYQ63_RS05300	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HYQ63_RS05325	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYQ63_RS05330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYQ63_RS05365	COG3852	Histidine kinase
HYQ63_RS05390	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HYQ63_RS05415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYQ63_RS05425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYQ63_RS05450	COG0601	transmembrane transport
HYQ63_RS05460	COG0444	Belongs to the ABC transporter superfamily
HYQ63_RS05465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYQ63_RS05470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYQ63_RS05475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYQ63_RS05490	COG3622	Belongs to the hyi family
HYQ63_RS05495	COG2084	Dehydrogenase
HYQ63_RS05500	COG3960	tartronate-semialdehyde synthase activity
HYQ63_RS05505	COG4266	Belongs to the allantoicase family
HYQ63_RS05515	COG0477	Major facilitator Superfamily
HYQ63_RS05530	COG1113	amino acid transport
HYQ63_RS05590	COG1113	amino acid transport
HYQ63_RS05595	COG2186	Transcriptional regulator
HYQ63_RS05600	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS05610	COG1129	ABC transporter
HYQ63_RS05615	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYQ63_RS05625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HYQ63_RS05650	COG2318	DinB family
HYQ63_RS05660	COG2378	regulation of single-species biofilm formation
HYQ63_RS05670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYQ63_RS05695	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HYQ63_RS05700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HYQ63_RS05720	COG0583	DNA-binding transcription factor activity
HYQ63_RS05760	COG1695	Transcriptional regulator
HYQ63_RS05765	COG0384	phenazine biosynthesis protein PhzF
HYQ63_RS05795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYQ63_RS05795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYQ63_RS05805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYQ63_RS05845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYQ63_RS05875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYQ63_RS05885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYQ63_RS05890	COG1126	abc transporter atp-binding protein
HYQ63_RS05895	COG0765	amino acid transport
HYQ63_RS05905	COG3835	regulator
HYQ63_RS05910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYQ63_RS05920	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HYQ63_RS05925	COG1177	transmembrane transport
HYQ63_RS05930	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYQ63_RS05935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HYQ63_RS05940	COG3842	ATPase activity
HYQ63_RS05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYQ63_RS05965	COG2018	Roadblock/LC7 domain
HYQ63_RS05985	COG2146	nitrite reductase [NAD(P)H] activity
HYQ63_RS06010	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS06015	COG0531	amino acid
HYQ63_RS06035	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HYQ63_RS06055	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HYQ63_RS06060	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HYQ63_RS06065	COG1984	allophanate hydrolase subunit 2
HYQ63_RS06075	COG2890	protein-(glutamine-N5) methyltransferase activity
HYQ63_RS06080	COG0723	plastoquinol--plastocyanin reductase activity
HYQ63_RS06080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYQ63_RS06105	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS06155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYQ63_RS06185	COG1024	Enoyl-CoA hydratase
HYQ63_RS06225	COG2267	carboxylic ester hydrolase activity
HYQ63_RS06235	COG2070	2-Nitropropane dioxygenase
HYQ63_RS06255	COG3842	ATPase activity
HYQ63_RS06260	COG1309	transcriptional regulator
HYQ63_RS06285	COG1902	pentaerythritol trinitrate reductase activity
HYQ63_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS06295	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS06305	COG2376	Dihydroxyacetone kinase
HYQ63_RS06310	COG1461	Dihydroxyacetone kinase
HYQ63_RS06315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYQ63_RS06315	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HYQ63_RS06315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYQ63_RS06330	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS06370	COG3217	Mosc domain protein beta barrel domain protein
HYQ63_RS06370	COG0633	Ferredoxin
HYQ63_RS06405	COG0464	growth
HYQ63_RS06415	COG1349	DNA-binding transcription factor activity
HYQ63_RS06455	COG1940	carbohydrate kinase activity
HYQ63_RS06460	COG0738	Major facilitator superfamily
HYQ63_RS06480	COG2197	response regulator
HYQ63_RS06485	COG4585	Histidine kinase
HYQ63_RS06495	COG0445	tRNA wobble uridine modification
HYQ63_RS06500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYQ63_RS06505	COG1660	Displays ATPase and GTPase activities
HYQ63_RS06510	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS06515	COG1175	transmembrane transport
HYQ63_RS06525	COG3345	alpha-galactosidase
HYQ63_RS06530	COG0515	serine threonine protein kinase
HYQ63_RS06530	COG2815	serine threonine protein kinase
HYQ63_RS06565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYQ63_RS06605	COG0584	glycerophosphoryl diester phosphodiesterase
HYQ63_RS06610	COG0456	acetyltransferase
HYQ63_RS06625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HYQ63_RS06630	COG1396	sequence-specific DNA binding
HYQ63_RS06645	COG0671	phosphoesterase, PA-phosphatase related
HYQ63_RS06685	COG2801	Transposase and inactivated derivatives
HYQ63_RS06685	COG3415	Transposase
HYQ63_RS06700	COG1132	(ABC) transporter
HYQ63_RS06705	COG1051	belongs to the nudix hydrolase family
HYQ63_RS06735	COG0596	Alpha beta hydrolase
HYQ63_RS06770	COG0574	Belongs to the PEP-utilizing enzyme family
HYQ63_RS06770	COG3848	Pyruvate phosphate dikinase
HYQ63_RS06775	COG0583	DNA-binding transcription factor activity
HYQ63_RS06780	COG0183	Belongs to the thiolase family
HYQ63_RS06790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HYQ63_RS06805	COG0583	DNA-binding transcription factor activity
HYQ63_RS06830	COG0277	FAD linked oxidase domain protein
HYQ63_RS06865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYQ63_RS06875	COG0583	DNA-binding transcription factor activity
HYQ63_RS06890	COG1309	transcriptional regulator
HYQ63_RS06910	COG0640	Transcriptional regulator
HYQ63_RS06915	COG2409	Drug exporters of the RND superfamily
HYQ63_RS06920	COG4585	Histidine kinase
HYQ63_RS06925	COG2197	response regulator
HYQ63_RS06935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYQ63_RS06955	COG2706	6-phosphogluconolactonase activity
HYQ63_RS06965	COG1522	sequence-specific DNA binding
HYQ63_RS06970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYQ63_RS06995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYQ63_RS07000	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYQ63_RS07005	COG2080	2 iron, 2 sulfur cluster binding
HYQ63_RS07025	COG0235	Class ii aldolase
HYQ63_RS07065	COG0577	efflux transmembrane transporter activity
HYQ63_RS07065	COG1136	(ABC) transporter
HYQ63_RS07075	COG4977	sequence-specific DNA binding
HYQ63_RS07105	COG0542	response to heat
HYQ63_RS07125	COG0432	Pfam Uncharacterised protein family UPF0047
HYQ63_RS07130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYQ63_RS07135	COG1116	anion transmembrane transporter activity
HYQ63_RS07145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS07175	COG2072	flavoprotein involved in K transport
HYQ63_RS07180	COG1609	Transcriptional regulator
HYQ63_RS07215	COG1129	ABC transporter
HYQ63_RS07220	COG3250	beta-galactosidase activity
HYQ63_RS07230	COG3347	Dehydrogenase
HYQ63_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS07235	COG1070	Carbohydrate kinase
HYQ63_RS07240	COG0247	lactate metabolic process
HYQ63_RS07245	COG1139	Iron-sulfur cluster binding protein
HYQ63_RS07250	COG1556	Lactate utilization protein
HYQ63_RS07300	COG0789	Transcriptional regulator
HYQ63_RS07310	COG0738	Major facilitator superfamily
HYQ63_RS07340	COG1175	transmembrane transport
HYQ63_RS07345	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS07355	COG1126	abc transporter atp-binding protein
HYQ63_RS07360	COG0765	amino acid transport
HYQ63_RS07365	COG0765	amino acid transport
HYQ63_RS07370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYQ63_RS07375	COG1414	Transcriptional regulator
HYQ63_RS07410	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS07420	COG1940	carbohydrate kinase activity
HYQ63_RS07420	COG1846	Transcriptional regulator
HYQ63_RS07430	COG0154	amidase activity
HYQ63_RS07455	COG2186	Transcriptional regulator
HYQ63_RS07470	COG3030	protein affecting phage T7 exclusion by the F plasmid
HYQ63_RS07495	COG1006	Multisubunit Na H antiporter MnhC subunit
HYQ63_RS07500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYQ63_RS07510	COG0463	Glycosyl transferase, family 2
HYQ63_RS07535	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS07555	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS07565	COG5001	Diguanylate cyclase
HYQ63_RS07580	COG3835	regulator
HYQ63_RS07590	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS07595	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS07600	COG1802	Transcriptional regulator
HYQ63_RS07660	COG1846	Transcriptional regulator
HYQ63_RS07665	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS07685	COG3268	Saccharopine dehydrogenase
HYQ63_RS07695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS07730	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS07760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS07775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYQ63_RS07785	COG1454	alcohol dehydrogenase
HYQ63_RS07805	COG0515	serine threonine protein kinase
HYQ63_RS07815	COG4152	abc transporter atp-binding protein
HYQ63_RS07920	COG1959	2 iron, 2 sulfur cluster binding
HYQ63_RS07925	COG1309	transcriptional regulator
HYQ63_RS07930	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS07955	COG0778	Nitroreductase
HYQ63_RS07980	COG0477	Major facilitator Superfamily
HYQ63_RS07985	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS08000	COG1609	Transcriptional regulator
HYQ63_RS08010	COG0800	Aldolase
HYQ63_RS08015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYQ63_RS08015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYQ63_RS08030	COG1024	Enoyl-CoA hydratase
HYQ63_RS08045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYQ63_RS08115	COG2132	Multicopper oxidase
HYQ63_RS08160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYQ63_RS08170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYQ63_RS08185	COG1484	DNA-dependent DNA replication
HYQ63_RS08190	COG4584	PFAM Integrase catalytic
HYQ63_RS08260	COG2755	lipolytic protein G-D-S-L family
HYQ63_RS08265	COG1064	alcohol dehydrogenase
HYQ63_RS08270	COG1309	transcriptional regulator
HYQ63_RS08290	COG1609	Transcriptional regulator
HYQ63_RS08305	COG3345	alpha-galactosidase
HYQ63_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS08365	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS08370	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS08375	COG1175	transmembrane transport
HYQ63_RS08420	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYQ63_RS08425	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYQ63_RS08430	COG1129	ABC transporter
HYQ63_RS08450	COG3509	depolymerase
HYQ63_RS08475	COG0523	cobalamin synthesis protein
HYQ63_RS08490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYQ63_RS08495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYQ63_RS08500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYQ63_RS08505	COG0254	rRNA binding
HYQ63_RS08515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYQ63_RS08525	COG0640	Transcriptional regulator
HYQ63_RS08540	COG0523	cobalamin synthesis protein
HYQ63_RS08555	COG0701	Predicted permease
HYQ63_RS08580	COG1121	(ABC) transporter
HYQ63_RS08585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYQ63_RS08605	COG0561	phosphatase activity
HYQ63_RS08610	COG1846	Transcriptional regulator
HYQ63_RS08610	COG1940	carbohydrate kinase activity
HYQ63_RS08615	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS08640	COG4670	ketone body catabolic process
HYQ63_RS08675	COG0436	Aminotransferase
HYQ63_RS08705	COG1309	transcriptional regulator
HYQ63_RS08850	COG4638	Rieske (2fe-2S)
HYQ63_RS08855	COG2124	cytochrome p450
HYQ63_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS08910	COG2226	methyltransferase
HYQ63_RS08960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYQ63_RS08980	COG0789	Transcriptional regulator
HYQ63_RS08985	COG3959	Transketolase, thiamine diphosphate binding domain
HYQ63_RS08990	COG3958	Transketolase
HYQ63_RS08995	COG2267	carboxylic ester hydrolase activity
HYQ63_RS09000	COG1228	amidohydrolase
HYQ63_RS09025	COG4175	Glycine betaine
HYQ63_RS09025	COG0517	IMP dehydrogenase activity
HYQ63_RS09030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYQ63_RS09055	COG0805	protein transport
HYQ63_RS09060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYQ63_RS09080	COG2378	regulation of single-species biofilm formation
HYQ63_RS09090	COG0545	Peptidyl-prolyl cis-trans isomerase
HYQ63_RS09095	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HYQ63_RS09105	COG1609	Transcriptional regulator
HYQ63_RS09110	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HYQ63_RS09115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HYQ63_RS09130	COG4122	O-methyltransferase activity
HYQ63_RS09135	COG1222	aaa ATPase
HYQ63_RS09155	COG1994	Peptidase M50
HYQ63_RS09155	COG0517	IMP dehydrogenase activity
HYQ63_RS09165	COG2197	response regulator
HYQ63_RS09180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYQ63_RS09185	COG1410	methionine synthase
HYQ63_RS09185	COG0646	methionine synthase
HYQ63_RS09190	COG1414	Transcriptional regulator
HYQ63_RS09195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HYQ63_RS09200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYQ63_RS09205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HYQ63_RS09215	COG2186	Transcriptional regulator
HYQ63_RS09220	COG3618	amidohydrolase
HYQ63_RS09230	COG4211	Belongs to the binding-protein-dependent transport system permease family
HYQ63_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS09250	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS09260	COG0215	cysteine-tRNA ligase activity
HYQ63_RS09275	COG0406	alpha-ribazole phosphatase activity
HYQ63_RS09280	COG0598	Magnesium transport protein CorA
HYQ63_RS09290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS09295	COG0667	Aldo Keto reductase
HYQ63_RS09320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYQ63_RS09355	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS09375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYQ63_RS09380	COG2080	2 iron, 2 sulfur cluster binding
HYQ63_RS09385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYQ63_RS09390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYQ63_RS09405	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS09430	COG3573	Dehydrogenase
HYQ63_RS09440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HYQ63_RS09445	COG2149	membrane
HYQ63_RS09465	COG1733	regulation of RNA biosynthetic process
HYQ63_RS09475	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS09485	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS09490	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS09535	COG2851	Citrate transporter
HYQ63_RS09540	COG3383	formate dehydrogenase (NAD+) activity
HYQ63_RS09545	COG1309	transcriptional regulator
HYQ63_RS09550	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HYQ63_RS09555	COG2188	Transcriptional regulator
HYQ63_RS09585	COG0515	serine threonine protein kinase
HYQ63_RS09605	COG0463	Glycosyl transferase, family 2
HYQ63_RS09635	COG1834	amidinotransferase
HYQ63_RS09640	COG1725	Transcriptional regulator
HYQ63_RS09655	COG2226	methyltransferase
HYQ63_RS09670	COG1609	Transcriptional regulator
HYQ63_RS09675	COG0019	diaminopimelate decarboxylase activity
HYQ63_RS09680	COG4264	IucA IucC family
HYQ63_RS09715	COG1846	Transcriptional regulator
HYQ63_RS09720	COG1764	response to oxidative stress
HYQ63_RS09725	COG1280	lysine exporter protein (LysE YggA)
HYQ63_RS09735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYQ63_RS09740	COG0587	DNA-directed DNA polymerase activity
HYQ63_RS09745	COG3467	pyridoxamine 5'-phosphate
HYQ63_RS09760	COG0330	HflC and HflK could
HYQ63_RS09770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS09775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS09785	COG1126	abc transporter atp-binding protein
HYQ63_RS09805	COG1799	cell septum assembly
HYQ63_RS09810	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS09815	COG0477	Major facilitator Superfamily
HYQ63_RS09825	COG0671	phosphoesterase, PA-phosphatase related
HYQ63_RS09875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYQ63_RS09890	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS09905	COG1160	GTP binding
HYQ63_RS09915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYQ63_RS09930	COG1187	pseudouridine synthase activity
HYQ63_RS09935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYQ63_RS09940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYQ63_RS09955	COG0686	Belongs to the AlaDH PNT family
HYQ63_RS09965	COG0494	nUDIX hydrolase
HYQ63_RS09970	COG0504	CTP synthase activity
HYQ63_RS09975	COG3387	PFAM Glycoside hydrolase 15-related
HYQ63_RS09990	COG0297	glycogen (starch) synthase activity
HYQ63_RS09995	COG0497	DNA recombination
HYQ63_RS10000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYQ63_RS10020	COG1120	ATPase activity
HYQ63_RS10025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYQ63_RS10030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYQ63_RS10035	COG0647	UMP catabolic process
HYQ63_RS10065	COG2094	Belongs to the DNA glycosylase MPG family
HYQ63_RS10080	COG1881	PFAM PEBP family protein
HYQ63_RS10100	COG1119	ATPase activity
HYQ63_RS10115	COG2197	response regulator
HYQ63_RS10130	COG1716	ATPase activity
HYQ63_RS10130	COG1131	(ABC) transporter
HYQ63_RS10130	COG0842	Transport permease protein
HYQ63_RS10135	COG0560	Phosphoserine phosphatase
HYQ63_RS10135	COG3830	Belongs to the UPF0237 family
HYQ63_RS10150	COG2807	transmembrane transport
HYQ63_RS10155	COG2186	Transcriptional regulator
HYQ63_RS10165	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HYQ63_RS10170	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS10185	COG1902	pentaerythritol trinitrate reductase activity
HYQ63_RS10195	COG2807	transmembrane transport
HYQ63_RS10220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYQ63_RS10240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYQ63_RS10245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYQ63_RS10270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYQ63_RS10285	COG3387	PFAM Glycoside hydrolase 15-related
HYQ63_RS10340	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS10345	COG1846	Transcriptional regulator
HYQ63_RS10375	COG1024	Enoyl-CoA hydratase
HYQ63_RS10385	COG0488	(ABC) transporter
HYQ63_RS10400	COG0235	Class ii aldolase
HYQ63_RS10415	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HYQ63_RS10420	COG1492	cobalamin metabolic process
HYQ63_RS10435	COG1797	cobyrinic acid a,c-diamide synthase activity
HYQ63_RS10475	COG0456	acetyltransferase
HYQ63_RS10485	COG1917	Cupin 2, conserved barrel domain protein
HYQ63_RS10490	COG5285	phytanoyl-CoA dioxygenase
HYQ63_RS10505	COG1414	Transcriptional regulator
HYQ63_RS10515	COG4585	Histidine kinase
HYQ63_RS10520	COG2197	response regulator
HYQ63_RS10525	COG0667	Aldo Keto reductase
HYQ63_RS10535	COG3866	Pectate lyase
HYQ63_RS10540	COG2755	lipolytic protein G-D-S-L family
HYQ63_RS10550	COG4677	pectinesterase activity
HYQ63_RS10570	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS10590	COG1802	Transcriptional regulator
HYQ63_RS10625	COG0714	Associated with various cellular activities
HYQ63_RS10645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYQ63_RS10650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYQ63_RS10660	COG0789	Transcriptional regulator
HYQ63_RS10685	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS10690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYQ63_RS10695	COG0583	DNA-binding transcription factor activity
HYQ63_RS10710	COG2814	Major facilitator Superfamily
HYQ63_RS10715	COG1846	Transcriptional regulator
HYQ63_RS10760	COG0477	Major facilitator Superfamily
HYQ63_RS10765	COG1846	Transcriptional regulator
HYQ63_RS10845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS10865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYQ63_RS10870	COG2171	N-acyltransferase activity
HYQ63_RS10875	COG3226	Transcriptional regulator
HYQ63_RS10880	COG2076	Multidrug Resistance protein
HYQ63_RS10885	COG2151	metal-sulfur cluster biosynthetic enzyme
HYQ63_RS10890	COG0822	iron-sulfur transferase activity
HYQ63_RS10895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYQ63_RS10900	COG0396	ATPase activity
HYQ63_RS10910	COG0719	Fe-S assembly protein
HYQ63_RS10935	COG1612	heme a metabolic process
HYQ63_RS10950	COG0109	protoheme IX farnesyltransferase activity
HYQ63_RS10955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYQ63_RS10960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYQ63_RS10975	COG0363	glucosamine-6-phosphate deaminase activity
HYQ63_RS10980	COG0166	Belongs to the GPI family
HYQ63_RS10990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYQ63_RS10995	COG0149	triose-phosphate isomerase activity
HYQ63_RS11000	COG0126	phosphoglycerate kinase activity
HYQ63_RS11005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYQ63_RS11015	COG1481	regulation of sporulation
HYQ63_RS11025	COG1660	Displays ATPase and GTPase activities
HYQ63_RS11030	COG0322	excinuclease ABC activity
HYQ63_RS11050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYQ63_RS11055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYQ63_RS11075	COG0556	nucleotide-excision repair
HYQ63_RS11080	COG0584	glycerophosphoryl diester phosphodiesterase
HYQ63_RS11085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYQ63_RS11135	COG0237	dephospho-CoA kinase activity
HYQ63_RS11145	COG0539	negative regulation of cytoplasmic translation
HYQ63_RS11155	COG1643	Atp-dependent helicase
HYQ63_RS11170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HYQ63_RS11195	COG2050	protein possibly involved in aromatic compounds catabolism
HYQ63_RS11215	COG0411	ABC transporter
HYQ63_RS11250	COG0737	Belongs to the 5'-nucleotidase family
HYQ63_RS11270	COG1605	Chorismate mutase
HYQ63_RS11270	COG0287	Prephenate dehydrogenase
HYQ63_RS11285	COG3467	pyridoxamine 5'-phosphate
HYQ63_RS11295	COG0070	glutamate synthase
HYQ63_RS11295	COG0067	glutamate synthase
HYQ63_RS11295	COG0069	glutamate synthase activity
HYQ63_RS11305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYQ63_RS11315	COG0159	tryptophan synthase activity
HYQ63_RS11320	COG0133	tryptophan synthase activity
HYQ63_RS11325	COG0134	indole-3-glycerol-phosphate synthase activity
HYQ63_RS11350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HYQ63_RS11365	COG2076	Multidrug Resistance protein
HYQ63_RS11375	COG1609	Transcriptional regulator
HYQ63_RS11380	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS11395	COG1902	pentaerythritol trinitrate reductase activity
HYQ63_RS11400	COG0789	Transcriptional regulator
HYQ63_RS11415	COG0107	imidazoleglycerol-phosphate synthase activity
HYQ63_RS11420	COG0251	oxidation-reduction process
HYQ63_RS11425	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HYQ63_RS11430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HYQ63_RS11440	COG0131	Imidazoleglycerol-phosphate dehydratase
HYQ63_RS11445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYQ63_RS11450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HYQ63_RS11460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYQ63_RS11465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYQ63_RS11485	COG1432	Conserved Protein
HYQ63_RS11495	COG0587	DNA-directed DNA polymerase activity
HYQ63_RS11540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYQ63_RS11550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYQ63_RS11555	COG3599	regulation of cell shape
HYQ63_RS11565	COG1799	cell septum assembly
HYQ63_RS11580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYQ63_RS11585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HYQ63_RS11590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYQ63_RS11600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYQ63_RS11605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYQ63_RS11615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYQ63_RS11620	COG0768	penicillin binding
HYQ63_RS11630	COG0275	rRNA processing
HYQ63_RS11640	COG0714	Associated with various cellular activities
HYQ63_RS11660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYQ63_RS11680	COG1309	transcriptional regulator
HYQ63_RS11685	COG1233	COG1233 Phytoene dehydrogenase and related
HYQ63_RS11700	COG0352	thiamine-phosphate diphosphorylase activity
HYQ63_RS11710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYQ63_RS11715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYQ63_RS11715	COG2022	thiamine diphosphate biosynthetic process
HYQ63_RS11725	COG2022	thiamine diphosphate biosynthetic process
HYQ63_RS11735	COG0515	serine threonine protein kinase
HYQ63_RS11735	COG2815	serine threonine protein kinase
HYQ63_RS11755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HYQ63_RS11770	COG3479	Phenolic acid decarboxylase
HYQ63_RS11775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HYQ63_RS11780	COG2193	ferroxidase activity
HYQ63_RS11785	COG0243	molybdopterin cofactor binding
HYQ63_RS11790	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HYQ63_RS11830	COG0477	Major facilitator Superfamily
HYQ63_RS11840	COG0205	6-phosphofructokinase activity
HYQ63_RS11845	COG2197	response regulator
HYQ63_RS11875	COG1940	carbohydrate kinase activity
HYQ63_RS11885	COG0003	Pfam Anion-transporting ATPase
HYQ63_RS11920	COG0791	NLP P60 protein
HYQ63_RS11945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYQ63_RS11950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYQ63_RS11955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HYQ63_RS11960	COG0723	plastoquinol--plastocyanin reductase activity
HYQ63_RS11965	COG2010	Cytochrome c
HYQ63_RS11970	COG1845	cytochrome c oxidase, subunit III
HYQ63_RS11980	COG1376	ErfK ybiS ycfS ynhG family protein
HYQ63_RS11990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYQ63_RS11995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HYQ63_RS12005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYQ63_RS12025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HYQ63_RS12030	COG2197	response regulator
HYQ63_RS12035	COG4585	Histidine kinase
HYQ63_RS12070	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HYQ63_RS12075	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYQ63_RS12080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYQ63_RS12085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYQ63_RS12090	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYQ63_RS12100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HYQ63_RS12120	COG0456	acetyltransferase
HYQ63_RS12145	COG0640	Transcriptional regulator
HYQ63_RS12155	COG0321	lipoyl(octanoyl) transferase activity
HYQ63_RS12160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYQ63_RS12210	COG4585	Histidine kinase
HYQ63_RS12215	COG2197	response regulator
HYQ63_RS12230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HYQ63_RS12255	COG0477	Major facilitator Superfamily
HYQ63_RS12275	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS12290	COG2197	response regulator
HYQ63_RS12315	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS12325	COG2182	Extracellular solute-binding protein
HYQ63_RS12330	COG0366	Alpha amylase catalytic
HYQ63_RS12335	COG1609	Transcriptional regulator
HYQ63_RS12345	COG0561	phosphatase activity
HYQ63_RS12350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYQ63_RS12395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HYQ63_RS12400	COG0589	response to stress
HYQ63_RS12405	COG2814	Major facilitator Superfamily
HYQ63_RS12410	COG1082	Xylose isomerase domain protein TIM barrel
HYQ63_RS12415	COG1609	Transcriptional regulator
HYQ63_RS12420	COG0174	glutamine synthetase
HYQ63_RS12425	COG2132	Multicopper oxidase
HYQ63_RS12430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYQ63_RS12430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYQ63_RS12435	COG3795	YCII-related domain
HYQ63_RS12440	COG4941	Belongs to the sigma-70 factor family
HYQ63_RS12455	COG3321	synthase
HYQ63_RS12455	COG0604	alcohol dehydrogenase
HYQ63_RS12460	COG2814	Major facilitator Superfamily
HYQ63_RS12470	COG1309	transcriptional regulator
HYQ63_RS12475	COG0477	Major facilitator Superfamily
HYQ63_RS12480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HYQ63_RS12500	COG1994	Peptidase M50
HYQ63_RS12515	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS12520	COG1175	transmembrane transport
HYQ63_RS12560	COG5398	heme oxygenase
HYQ63_RS12570	COG1120	ATPase activity
HYQ63_RS12575	COG2822	iron ion transport
HYQ63_RS12580	COG2837	iron assimilation
HYQ63_RS12585	COG0672	)-iron permease
HYQ63_RS12615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYQ63_RS12620	COG2814	Major facilitator Superfamily
HYQ63_RS12630	COG3540	Alkaline phosphatase
HYQ63_RS12635	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS12655	COG0583	DNA-binding transcription factor activity
HYQ63_RS12665	COG0488	(ABC) transporter
HYQ63_RS12670	COG2378	regulation of single-species biofilm formation
HYQ63_RS12690	COG0583	DNA-binding transcription factor activity
HYQ63_RS12790	COG2801	Transposase and inactivated derivatives
HYQ63_RS12790	COG3415	Transposase
HYQ63_RS12810	COG0366	Alpha amylase catalytic
HYQ63_RS12815	COG3022	response to hydroperoxide
HYQ63_RS12820	COG0800	Aldolase
HYQ63_RS12835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYQ63_RS12840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYQ63_RS12855	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS12865	COG2030	dehydratase
HYQ63_RS12885	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS12895	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYQ63_RS12905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS12925	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS12930	COG1309	transcriptional regulator
HYQ63_RS12935	COG2197	response regulator
HYQ63_RS12990	COG3845	ABC transporter
HYQ63_RS13025	COG0183	Belongs to the thiolase family
HYQ63_RS13030	COG2124	cytochrome p450
HYQ63_RS13055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYQ63_RS13070	COG0010	Belongs to the arginase family
HYQ63_RS13080	COG5002	protein histidine kinase activity
HYQ63_RS13180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYQ63_RS13200	COG1196	nuclear chromosome segregation
HYQ63_RS13200	COG0741	lytic transglycosylase activity
HYQ63_RS13200	COG0739	heme binding
HYQ63_RS13255	COG2315	Protein conserved in bacteria
HYQ63_RS13275	COG1280	lysine exporter protein (LysE YggA)
HYQ63_RS13315	COG4585	Histidine kinase
HYQ63_RS13320	COG0586	Pfam SNARE associated Golgi protein
HYQ63_RS13330	COG1358	cellular component organization or biogenesis
HYQ63_RS13385	COG0477	Major facilitator Superfamily
HYQ63_RS13390	COG1309	transcriptional regulator
HYQ63_RS13405	COG4585	Histidine kinase
HYQ63_RS13410	COG2197	response regulator
HYQ63_RS13430	COG0789	Transcriptional regulator
HYQ63_RS13445	COG2271	Major facilitator Superfamily
HYQ63_RS13450	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS13455	COG1063	alcohol dehydrogenase
HYQ63_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS13480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYQ63_RS13485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS13490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYQ63_RS13515	COG1309	transcriptional regulator
HYQ63_RS13565	COG1129	ABC transporter
HYQ63_RS13570	COG4214	carbohydrate transport
HYQ63_RS13595	COG3866	Pectate lyase
HYQ63_RS13615	COG3507	Belongs to the glycosyl hydrolase 43 family
HYQ63_RS13620	COG5520	Belongs to the glycosyl hydrolase 30 family
HYQ63_RS13630	COG2130	NADP-dependent
HYQ63_RS13645	COG3386	PFAM SMP-30 Gluconolaconase
HYQ63_RS13650	COG1414	Transcriptional regulator
HYQ63_RS13675	COG0500	methyltransferase
HYQ63_RS13680	COG4981	capsule polysaccharide biosynthetic process
HYQ63_RS13715	COG0588	phosphoglycerate mutase activity
HYQ63_RS13720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYQ63_RS13725	COG2318	DinB family
HYQ63_RS13740	COG3209	COG3209 Rhs family protein
HYQ63_RS13750	COG4221	oxidoreductase activity
HYQ63_RS13775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYQ63_RS13800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYQ63_RS13810	COG4257	antibiotic catabolic process
HYQ63_RS13870	COG0477	Major facilitator Superfamily
HYQ63_RS13885	COG1621	beta-fructofuranosidase activity
HYQ63_RS13895	COG1175	transmembrane transport
HYQ63_RS13900	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS13905	COG1621	beta-fructofuranosidase activity
HYQ63_RS13910	COG1609	Transcriptional regulator
HYQ63_RS13920	COG2814	Major facilitator Superfamily
HYQ63_RS13975	COG2890	protein-(glutamine-N5) methyltransferase activity
HYQ63_RS13995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYQ63_RS14040	COG1070	Carbohydrate kinase
HYQ63_RS14045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYQ63_RS14050	COG0358	DNA primase activity
HYQ63_RS14060	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYQ63_RS14075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYQ63_RS14085	COG2949	membrane
HYQ63_RS14170	COG2124	cytochrome p450
HYQ63_RS14175	COG2124	cytochrome p450
HYQ63_RS14180	COG2146	nitrite reductase [NAD(P)H] activity
HYQ63_RS14180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYQ63_RS14195	COG1609	Transcriptional regulator
HYQ63_RS14205	COG1175	transmembrane transport
HYQ63_RS14215	COG1472	Belongs to the glycosyl hydrolase 3 family
HYQ63_RS14230	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS14240	COG4585	Histidine kinase
HYQ63_RS14245	COG2197	response regulator
HYQ63_RS14270	COG2890	protein-(glutamine-N5) methyltransferase activity
HYQ63_RS14280	COG2271	Major facilitator Superfamily
HYQ63_RS14285	COG1063	alcohol dehydrogenase
HYQ63_RS14290	COG1414	Transcriptional regulator
HYQ63_RS14295	COG1846	Transcriptional regulator
HYQ63_RS14300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYQ63_RS14305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HYQ63_RS14310	COG0183	Belongs to the thiolase family
HYQ63_RS14315	COG3485	protocatechuate 3,4-dioxygenase
HYQ63_RS14320	COG3485	protocatechuate 3,4-dioxygenase
HYQ63_RS14325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYQ63_RS14330	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYQ63_RS14355	COG0574	Belongs to the PEP-utilizing enzyme family
HYQ63_RS14355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYQ63_RS14380	COG0477	Major facilitator Superfamily
HYQ63_RS14385	COG0667	Aldo Keto reductase
HYQ63_RS14400	COG0423	glycine-tRNA ligase activity
HYQ63_RS14410	COG1121	(ABC) transporter
HYQ63_RS14415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYQ63_RS14425	COG0346	lactoylglutathione lyase activity
HYQ63_RS14475	COG2124	cytochrome p450
HYQ63_RS14480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYQ63_RS14485	COG1381	Involved in DNA repair and RecF pathway recombination
HYQ63_RS14535	COG3422	double-strand break repair
HYQ63_RS14560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYQ63_RS14575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYQ63_RS14595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYQ63_RS14605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYQ63_RS14610	COG1234	tRNA 3'-trailer cleavage
HYQ63_RS14615	COG0537	adenosine 5'-monophosphoramidase activity
HYQ63_RS14625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYQ63_RS14645	COG0484	heat shock protein binding
HYQ63_RS14650	COG1420	regulation of RNA biosynthetic process
HYQ63_RS14675	COG1022	Amp-dependent synthetase and ligase
HYQ63_RS14680	COG0481	GTPase activity
HYQ63_RS14685	COG0268	Binds directly to 16S ribosomal RNA
HYQ63_RS14715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYQ63_RS14740	COG2801	Transposase and inactivated derivatives
HYQ63_RS14740	COG3415	Transposase
HYQ63_RS14785	COG1555	photosystem II stabilization
HYQ63_RS14790	COG1307	EDD domain protein, DegV family
HYQ63_RS14800	COG0495	leucyl-tRNA aminoacylation
HYQ63_RS14825	COG0406	alpha-ribazole phosphatase activity
HYQ63_RS14830	COG0799	negative regulation of ribosome biogenesis
HYQ63_RS14840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HYQ63_RS14855	COG0501	Belongs to the peptidase M48B family
HYQ63_RS14870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HYQ63_RS14880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HYQ63_RS14890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYQ63_RS14895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYQ63_RS14900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYQ63_RS14905	COG1530	ribonuclease E activity
HYQ63_RS14925	COG0772	Belongs to the SEDS family
HYQ63_RS14930	COG0768	penicillin binding
HYQ63_RS14945	COG1077	Cell shape determining protein MreB Mrl
HYQ63_RS14950	COG0105	UTP biosynthetic process
HYQ63_RS14960	COG0285	dihydrofolate synthase activity
HYQ63_RS14965	COG0768	penicillin binding
HYQ63_RS14990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYQ63_RS14995	COG0740	serine-type endopeptidase activity
HYQ63_RS15000	COG0740	serine-type endopeptidase activity
HYQ63_RS15005	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYQ63_RS15025	COG3594	Acyltransferase
HYQ63_RS15050	COG1113	amino acid transport
HYQ63_RS15060	COG1113	amino acid transport
HYQ63_RS15065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYQ63_RS15070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYQ63_RS15150	COG0668	transmembrane transport
HYQ63_RS15155	COG1846	Transcriptional regulator
HYQ63_RS15155	COG1940	carbohydrate kinase activity
HYQ63_RS15165	COG1175	transmembrane transport
HYQ63_RS15170	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS15175	COG1486	melibiose metabolic process
HYQ63_RS15190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYQ63_RS15220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYQ63_RS15250	COG0629	single-stranded DNA binding
HYQ63_RS15310	COG1074	ATP-dependent DNA helicase activity
HYQ63_RS15315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYQ63_RS15330	COG3883	PFAM NLP P60 protein
HYQ63_RS15330	COG0791	NLP P60 protein
HYQ63_RS15455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HYQ63_RS15470	COG1846	Transcriptional regulator
HYQ63_RS15480	COG1942	4-Oxalocrotonate Tautomerase
HYQ63_RS15520	COG3251	PFAM MbtH domain protein
HYQ63_RS15525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HYQ63_RS15530	COG1993	acr, cog1993
HYQ63_RS15535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HYQ63_RS15540	COG0583	DNA-binding transcription factor activity
HYQ63_RS15550	COG1053	succinate dehydrogenase
HYQ63_RS15555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYQ63_RS15575	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS15650	COG3402	PFAM membrane-flanked domain
HYQ63_RS15660	COG4585	Histidine kinase
HYQ63_RS15665	COG2197	response regulator
HYQ63_RS15695	COG3962	Belongs to the TPP enzyme family
HYQ63_RS15700	COG3718	enzyme involved in inositol metabolism
HYQ63_RS15710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYQ63_RS15720	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYQ63_RS15735	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS15740	COG1082	Xylose isomerase domain protein TIM barrel
HYQ63_RS15750	COG2409	Drug exporters of the RND superfamily
HYQ63_RS15775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYQ63_RS15780	COG1609	Transcriptional regulator
HYQ63_RS15785	COG1129	ABC transporter
HYQ63_RS15795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYQ63_RS15800	COG1869	D-ribose catabolic process
HYQ63_RS15810	COG1316	TRANSCRIPTIONal
HYQ63_RS15845	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS15860	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS15865	COG1175	transmembrane transport
HYQ63_RS15890	COG1609	Transcriptional regulator
HYQ63_RS15940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYQ63_RS15940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYQ63_RS15965	COG2264	protein methyltransferase activity
HYQ63_RS15990	COG1472	Belongs to the glycosyl hydrolase 3 family
HYQ63_RS16030	COG2197	response regulator
HYQ63_RS16035	COG4585	Histidine kinase
HYQ63_RS16065	COG1278	Cold shock
HYQ63_RS16070	COG0513	Belongs to the DEAD box helicase family
HYQ63_RS16080	COG1946	Acyl-CoA thioesterase
HYQ63_RS16090	COG1309	transcriptional regulator
HYQ63_RS16095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYQ63_RS16110	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS16135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYQ63_RS16140	COG0589	response to stress
HYQ63_RS16150	COG4977	sequence-specific DNA binding
HYQ63_RS16155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HYQ63_RS16200	COG1252	NADH dehydrogenase
HYQ63_RS16205	COG1595	DNA-templated transcription, initiation
HYQ63_RS16230	COG0477	Major facilitator Superfamily
HYQ63_RS16240	COG4733	cellulase activity
HYQ63_RS16240	COG5297	Belongs to the glycosyl hydrolase family 6
HYQ63_RS16245	COG5297	Belongs to the glycosyl hydrolase family 6
HYQ63_RS16250	COG5297	Belongs to the glycosyl hydrolase family 6
HYQ63_RS16280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HYQ63_RS16285	COG3979	chitinase
HYQ63_RS16305	COG0406	alpha-ribazole phosphatase activity
HYQ63_RS16350	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS16385	COG4585	Histidine kinase
HYQ63_RS16390	COG2197	response regulator
HYQ63_RS16410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS16425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYQ63_RS16430	COG0154	amidase activity
HYQ63_RS16440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYQ63_RS16445	COG0765	amino acid transport
HYQ63_RS16450	COG0765	amino acid transport
HYQ63_RS16455	COG1126	abc transporter atp-binding protein
HYQ63_RS16480	COG1309	transcriptional regulator
HYQ63_RS16485	COG2267	carboxylic ester hydrolase activity
HYQ63_RS16500	COG4770	biotin carboxylase activity
HYQ63_RS16515	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS16520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYQ63_RS16525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYQ63_RS16530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS16535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYQ63_RS16560	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HYQ63_RS16580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYQ63_RS16585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYQ63_RS16590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYQ63_RS16595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS16605	COG0477	Major facilitator Superfamily
HYQ63_RS16610	COG1063	alcohol dehydrogenase
HYQ63_RS16625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYQ63_RS16630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYQ63_RS16665	COG3397	chitin binding
HYQ63_RS16685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYQ63_RS16745	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS16750	COG1309	transcriptional regulator
HYQ63_RS16770	COG2186	Transcriptional regulator
HYQ63_RS16830	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS16835	COG4702	Belongs to the UPF0303 family
HYQ63_RS16860	COG0706	membrane insertase activity
HYQ63_RS16870	COG3764	Sortase (surface protein transpeptidase)
HYQ63_RS16875	COG2733	membrane
HYQ63_RS16905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYQ63_RS16910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYQ63_RS16930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYQ63_RS16940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HYQ63_RS16945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYQ63_RS16950	COG1263	PTS System
HYQ63_RS16955	COG1234	tRNA 3'-trailer cleavage
HYQ63_RS16975	COG1113	amino acid transport
HYQ63_RS16985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HYQ63_RS16995	COG1335	isochorismatase
HYQ63_RS17030	COG0277	FAD linked oxidase domain protein
HYQ63_RS17040	COG1595	DNA-templated transcription, initiation
HYQ63_RS17055	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HYQ63_RS17080	COG3654	unkown
HYQ63_RS17095	COG2855	membrane
HYQ63_RS17105	COG0583	DNA-binding transcription factor activity
HYQ63_RS17120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYQ63_RS17130	COG0300	oxidoreductase activity
HYQ63_RS17170	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HYQ63_RS17175	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS17180	COG1175	transmembrane transport
HYQ63_RS17200	COG2814	Major facilitator Superfamily
HYQ63_RS17210	COG1678	Uncharacterized ACR, COG1678
HYQ63_RS17215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYQ63_RS17220	COG0776	regulation of translation
HYQ63_RS17230	COG1278	Cold shock
HYQ63_RS17235	COG3973	AAA domain
HYQ63_RS17260	COG2223	nitrite transmembrane transporter activity
HYQ63_RS17285	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS17290	COG1501	Belongs to the glycosyl hydrolase 31 family
HYQ63_RS17295	COG2027	D-alanyl-D-alanine carboxypeptidase
HYQ63_RS17335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYQ63_RS17340	COG0793	Belongs to the peptidase S41A family
HYQ63_RS17345	COG2177	Part of the ABC transporter FtsEX involved in
HYQ63_RS17350	COG2884	Cell division ATP-binding protein ftsE
HYQ63_RS17365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HYQ63_RS17370	COG0515	serine threonine protein kinase
HYQ63_RS17375	COG0515	serine threonine protein kinase
HYQ63_RS17385	COG1653	transport
HYQ63_RS17390	COG1175	transmembrane transport
HYQ63_RS17395	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS17400	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS17440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYQ63_RS17450	COG2902	Dehydrogenase
HYQ63_RS17475	COG0653	protein targeting
HYQ63_RS17485	COG3214	Protein conserved in bacteria
HYQ63_RS17490	COG2197	response regulator
HYQ63_RS17495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HYQ63_RS17505	COG0823	Involved in the tonB-independent uptake of proteins
HYQ63_RS17510	COG5000	phosphorelay sensor kinase activity
HYQ63_RS17510	COG5002	protein histidine kinase activity
HYQ63_RS17515	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS17520	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYQ63_RS17550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HYQ63_RS17555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HYQ63_RS17555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HYQ63_RS17555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYQ63_RS17565	COG1482	cell wall glycoprotein biosynthetic process
HYQ63_RS17575	COG2835	tetraacyldisaccharide 4'-kinase activity
HYQ63_RS17580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYQ63_RS17585	COG1620	l-lactate permease
HYQ63_RS17620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYQ63_RS17625	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HYQ63_RS17625	COG0778	Nitroreductase
HYQ63_RS17655	COG1316	TRANSCRIPTIONal
HYQ63_RS17675	COG1316	TRANSCRIPTIONal
HYQ63_RS17705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYQ63_RS17710	COG1607	acyl-coa hydrolase
HYQ63_RS17715	COG1316	TRANSCRIPTIONal
HYQ63_RS17750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYQ63_RS17770	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS17775	COG3104	oligopeptide transport
HYQ63_RS17780	COG2027	D-alanyl-D-alanine carboxypeptidase
HYQ63_RS17810	COG1366	Belongs to the anti-sigma-factor antagonist family
HYQ63_RS17815	COG1191	sigma factor activity
HYQ63_RS17820	COG1228	amidohydrolase
HYQ63_RS17835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYQ63_RS17855	COG2986	histidine ammonia-lyase
HYQ63_RS17865	COG1174	glycine betaine transport
HYQ63_RS17870	COG1174	glycine betaine transport
HYQ63_RS17880	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYQ63_RS17885	COG3629	intracellular signal transduction
HYQ63_RS17885	COG3903	Transcriptional regulator
HYQ63_RS17900	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS17915	COG2755	lipolytic protein G-D-S-L family
HYQ63_RS17920	COG0183	Belongs to the thiolase family
HYQ63_RS17950	COG1136	(ABC) transporter
HYQ63_RS17955	COG0577	efflux transmembrane transporter activity
HYQ63_RS17960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYQ63_RS17965	COG1252	NADH dehydrogenase
HYQ63_RS17985	COG0148	phosphopyruvate hydratase activity
HYQ63_RS17995	COG3583	domain protein
HYQ63_RS18000	COG2124	cytochrome p450
HYQ63_RS18030	COG2124	cytochrome p450
HYQ63_RS18035	COG1024	Enoyl-CoA hydratase
HYQ63_RS18080	COG2986	histidine ammonia-lyase
HYQ63_RS18090	COG1024	Enoyl-CoA hydratase
HYQ63_RS18095	COG2124	cytochrome p450
HYQ63_RS18100	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HYQ63_RS18110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYQ63_RS18120	COG0424	maF-like protein
HYQ63_RS18130	COG4770	biotin carboxylase activity
HYQ63_RS18170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYQ63_RS18185	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS18190	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS18235	COG0640	Transcriptional regulator
HYQ63_RS18260	COG1595	DNA-templated transcription, initiation
HYQ63_RS18265	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS18270	COG2205	protein histidine kinase activity
HYQ63_RS18295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYQ63_RS18305	COG1404	Belongs to the peptidase S8 family
HYQ63_RS18315	COG0789	Transcriptional regulator
HYQ63_RS18330	COG1819	glycosyl
HYQ63_RS18335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HYQ63_RS18345	COG0583	DNA-binding transcription factor activity
HYQ63_RS18350	COG2814	Major facilitator Superfamily
HYQ63_RS18380	COG0488	(ABC) transporter
HYQ63_RS18415	COG1473	amidohydrolase
HYQ63_RS18415	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HYQ63_RS18425	COG2089	acid synthase
HYQ63_RS18430	COG1083	cytidylyl-transferase
HYQ63_RS18440	COG1216	Glycosyl transferase, family 2
HYQ63_RS18450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HYQ63_RS18510	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS18530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYQ63_RS18550	COG1063	alcohol dehydrogenase
HYQ63_RS18555	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS18565	COG3265	gluconokinase activity
HYQ63_RS18570	COG2186	Transcriptional regulator
HYQ63_RS18585	COG0667	Aldo Keto reductase
HYQ63_RS18595	COG0667	Aldo Keto reductase
HYQ63_RS18660	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS18680	COG0587	DNA-directed DNA polymerase activity
HYQ63_RS18685	COG0596	Alpha beta hydrolase
HYQ63_RS18690	COG3903	Transcriptional regulator
HYQ63_RS18690	COG3629	intracellular signal transduction
HYQ63_RS18715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYQ63_RS18715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYQ63_RS18730	COG1595	DNA-templated transcription, initiation
HYQ63_RS18750	COG2009	succinate dehydrogenase
HYQ63_RS18760	COG1053	succinate dehydrogenase
HYQ63_RS18770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYQ63_RS18770	COG0515	serine threonine protein kinase
HYQ63_RS18775	COG1408	metallophosphoesterase
HYQ63_RS18785	COG1295	ribonuclease BN
HYQ63_RS18795	COG0180	Tryptophanyl-tRNA synthetase
HYQ63_RS18800	COG1595	DNA-templated transcription, initiation
HYQ63_RS18805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYQ63_RS18810	COG0754	glutathionylspermidine amidase activity
HYQ63_RS18820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYQ63_RS18825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYQ63_RS18830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HYQ63_RS18840	COG4176	ABC-type proline glycine betaine transport system permease component
HYQ63_RS18845	COG4175	Glycine betaine
HYQ63_RS18845	COG0517	IMP dehydrogenase activity
HYQ63_RS18855	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS18880	COG0039	L-malate dehydrogenase activity
HYQ63_RS18895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYQ63_RS18900	COG0138	bifunctional purine biosynthesis protein purh
HYQ63_RS18925	COG0045	succinate-CoA ligase (ADP-forming) activity
HYQ63_RS18940	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HYQ63_RS18950	COG0714	Associated with various cellular activities
HYQ63_RS18965	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYQ63_RS18975	COG0739	heme binding
HYQ63_RS19020	COG0789	Transcriptional regulator
HYQ63_RS19025	COG0789	Transcriptional regulator
HYQ63_RS19030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYQ63_RS19035	COG3903	Transcriptional regulator
HYQ63_RS19035	COG3629	intracellular signal transduction
HYQ63_RS19070	COG1335	isochorismatase
HYQ63_RS19100	COG1309	transcriptional regulator
HYQ63_RS19125	COG3293	Transposase
HYQ63_RS19155	COG2197	response regulator
HYQ63_RS19180	COG2815	serine threonine protein kinase
HYQ63_RS19180	COG0515	serine threonine protein kinase
HYQ63_RS19205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYQ63_RS19205	COG0519	Catalyzes the synthesis of GMP from XMP
HYQ63_RS19225	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS19230	COG2815	serine threonine protein kinase
HYQ63_RS19230	COG0515	serine threonine protein kinase
HYQ63_RS19255	COG2197	response regulator
HYQ63_RS19260	COG4585	Histidine kinase
HYQ63_RS19310	COG1131	(ABC) transporter
HYQ63_RS19330	COG0596	Alpha beta hydrolase
HYQ63_RS19330	COG2945	thiolester hydrolase activity
HYQ63_RS19340	COG4821	SIS domain
HYQ63_RS19350	COG0259	pyridoxamine-phosphate oxidase activity
HYQ63_RS19370	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS19385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYQ63_RS19405	COG0247	lactate metabolic process
HYQ63_RS19405	COG0277	FAD linked oxidase domain protein
HYQ63_RS19410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HYQ63_RS19425	COG0667	Aldo Keto reductase
HYQ63_RS19445	COG2252	PERMEase
HYQ63_RS19475	COG2814	Major facilitator Superfamily
HYQ63_RS19485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYQ63_RS19490	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HYQ63_RS19495	COG1278	Cold shock
HYQ63_RS19510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYQ63_RS19515	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYQ63_RS19520	COG1120	ATPase activity
HYQ63_RS19525	COG2801	Transposase and inactivated derivatives
HYQ63_RS19525	COG3415	Transposase
HYQ63_RS19555	COG3973	AAA domain
HYQ63_RS19610	COG2814	Major facilitator Superfamily
HYQ63_RS19630	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HYQ63_RS19635	COG0459	protein refolding
HYQ63_RS19640	COG1278	Cold shock
HYQ63_RS19655	COG0463	Glycosyl transferase, family 2
HYQ63_RS19660	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HYQ63_RS19665	COG1877	trehalose-phosphatase activity
HYQ63_RS19665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYQ63_RS19680	COG1940	carbohydrate kinase activity
HYQ63_RS19685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYQ63_RS19710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYQ63_RS19760	COG2755	lipolytic protein G-D-S-L family
HYQ63_RS19760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HYQ63_RS19810	COG3842	ATPase activity
HYQ63_RS19820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYQ63_RS19830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYQ63_RS19835	COG0215	cysteine-tRNA ligase activity
HYQ63_RS19845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYQ63_RS19850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYQ63_RS19855	COG1329	Transcriptional regulator
HYQ63_RS19870	COG5002	protein histidine kinase activity
HYQ63_RS19885	COG1215	transferase activity, transferring glycosyl groups
HYQ63_RS19910	COG0588	phosphoglycerate mutase activity
HYQ63_RS19930	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS19945	COG0667	Aldo Keto reductase
HYQ63_RS19965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HYQ63_RS19970	COG0456	acetyltransferase
HYQ63_RS19970	COG0454	-acetyltransferase
HYQ63_RS19975	COG0737	Belongs to the 5'-nucleotidase family
HYQ63_RS20000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HYQ63_RS20020	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYQ63_RS20030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYQ63_RS20035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYQ63_RS20055	COG0640	Transcriptional regulator
HYQ63_RS20060	COG2197	response regulator
HYQ63_RS20080	COG0649	NAD binding
HYQ63_RS20095	COG1174	glycine betaine transport
HYQ63_RS20100	COG1174	glycine betaine transport
HYQ63_RS20105	COG0517	IMP dehydrogenase activity
HYQ63_RS20105	COG1125	glycine betaine transport
HYQ63_RS20115	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HYQ63_RS20115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYQ63_RS20130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HYQ63_RS20135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HYQ63_RS20145	COG0302	gtp cyclohydrolase
HYQ63_RS20160	COG0037	tRNA processing
HYQ63_RS20170	COG2027	D-alanyl-D-alanine carboxypeptidase
HYQ63_RS20175	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HYQ63_RS20185	COG0586	Pfam SNARE associated Golgi protein
HYQ63_RS20190	COG0789	Transcriptional regulator
HYQ63_RS20200	COG0076	glutamate decarboxylase activity
HYQ63_RS20225	COG2318	DinB family
HYQ63_RS20230	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS20255	COG3940	Belongs to the glycosyl hydrolase 43 family
HYQ63_RS20260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYQ63_RS20260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYQ63_RS20265	COG1077	Cell shape determining protein MreB Mrl
HYQ63_RS20280	COG1595	DNA-templated transcription, initiation
HYQ63_RS20290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HYQ63_RS20295	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS20305	COG1404	Belongs to the peptidase S8 family
HYQ63_RS20335	COG4585	Histidine kinase
HYQ63_RS20340	COG2197	response regulator
HYQ63_RS20345	COG2197	response regulator
HYQ63_RS20350	COG4585	Histidine kinase
HYQ63_RS20385	COG1191	sigma factor activity
HYQ63_RS20405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYQ63_RS20410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYQ63_RS20415	COG1754	DNA topoisomerase type I activity
HYQ63_RS20415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYQ63_RS20425	COG2890	protein-(glutamine-N5) methyltransferase activity
HYQ63_RS20435	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HYQ63_RS20440	COG2172	sigma factor antagonist activity
HYQ63_RS20445	COG1366	Belongs to the anti-sigma-factor antagonist family
HYQ63_RS20450	COG1205	dead DEAH box helicase
HYQ63_RS20450	COG1111	helicase
HYQ63_RS20510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYQ63_RS20515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HYQ63_RS20550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYQ63_RS20575	COG0003	Pfam Anion-transporting ATPase
HYQ63_RS20585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYQ63_RS20595	COG1408	metallophosphoesterase
HYQ63_RS20610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HYQ63_RS20615	COG1846	Transcriptional regulator
HYQ63_RS20660	COG2124	cytochrome p450
HYQ63_RS20705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYQ63_RS20710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYQ63_RS20750	COG1401	restriction endodeoxyribonuclease activity
HYQ63_RS20760	COG2814	Major facilitator Superfamily
HYQ63_RS20765	COG1309	transcriptional regulator
HYQ63_RS20770	COG0598	Magnesium transport protein CorA
HYQ63_RS20775	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYQ63_RS20785	COG2124	cytochrome p450
HYQ63_RS20840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYQ63_RS20845	COG0436	Aminotransferase
HYQ63_RS20850	COG4221	oxidoreductase activity
HYQ63_RS20860	COG1984	allophanate hydrolase subunit 2
HYQ63_RS20865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HYQ63_RS20870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HYQ63_RS20910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYQ63_RS20925	COG3594	Acyltransferase
HYQ63_RS20935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYQ63_RS20945	COG0702	epimerase
HYQ63_RS20960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYQ63_RS20975	COG0590	tRNA wobble adenosine to inosine editing
HYQ63_RS21040	COG0205	6-phosphofructokinase activity
HYQ63_RS21050	COG1191	sigma factor activity
HYQ63_RS21055	COG1191	sigma factor activity
HYQ63_RS21080	COG2353	YceI-like domain
HYQ63_RS21090	COG0477	Major facilitator Superfamily
HYQ63_RS21095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HYQ63_RS21105	COG2205	protein histidine kinase activity
HYQ63_RS21110	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS21185	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS21190	COG1595	DNA-templated transcription, initiation
HYQ63_RS21210	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS21220	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS21255	COG0640	Transcriptional regulator
HYQ63_RS21260	COG0798	PFAM Bile acid sodium symporter
HYQ63_RS21265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYQ63_RS21280	COG1476	TRANSCRIPTIONal
HYQ63_RS21360	COG1051	belongs to the nudix hydrolase family
HYQ63_RS21390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYQ63_RS21405	COG0653	protein targeting
HYQ63_RS21420	COG0006	proline dipeptidase activity
HYQ63_RS21445	COG1999	signal sequence binding
HYQ63_RS21460	COG2837	iron assimilation
HYQ63_RS21470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYQ63_RS21475	COG0561	phosphatase activity
HYQ63_RS21500	COG2807	transmembrane transport
HYQ63_RS21525	COG1131	(ABC) transporter
HYQ63_RS21545	COG0501	Belongs to the peptidase M48B family
HYQ63_RS21555	COG0561	phosphatase activity
HYQ63_RS21570	COG4988	ABC transporter
HYQ63_RS21575	COG1294	oxidase, subunit
HYQ63_RS21580	COG1271	oxidase subunit
HYQ63_RS21585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYQ63_RS21590	COG1609	Transcriptional regulator
HYQ63_RS21610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HYQ63_RS21630	COG0662	Cupin 2, conserved barrel domain protein
HYQ63_RS21635	COG1950	PFAM Membrane protein of
HYQ63_RS21640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYQ63_RS21645	COG0626	cystathionine gamma-synthase activity
HYQ63_RS21700	COG2226	methyltransferase
HYQ63_RS21705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYQ63_RS21715	COG0242	peptide deformylase activity
HYQ63_RS21720	COG0305	Participates in initiation and elongation during chromosome replication
HYQ63_RS21725	COG0534	Mate efflux family protein
HYQ63_RS21730	COG0359	binds to the 23S rRNA
HYQ63_RS21735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYQ63_RS21740	COG0629	single-stranded DNA binding
HYQ63_RS21745	COG0360	Binds together with S18 to 16S ribosomal RNA
HYQ63_RS21770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYQ63_RS21790	COG0617	tRNA 3'-terminal CCA addition
HYQ63_RS21805	COG0515	serine threonine protein kinase
HYQ63_RS21805	COG2815	serine threonine protein kinase
HYQ63_RS21810	COG1595	DNA-templated transcription, initiation
HYQ63_RS21825	COG3118	belongs to the thioredoxin family
HYQ63_RS21840	COG1192	Involved in chromosome partitioning
HYQ63_RS21845	COG0357	Ribosomal RNA small subunit methyltransferase G
HYQ63_RS21855	COG0706	membrane insertase activity
HYQ63_RS21860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYQ63_RS21865	COG0594	ribonuclease P activity
HYQ63_RS21870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYQ63_RS21880	COG0592	DNA-directed DNA polymerase activity
HYQ63_RS21885	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HYQ63_RS21890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYQ63_RS21895	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HYQ63_RS21900	COG0187	DNA topoisomerase II activity
HYQ63_RS21905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYQ63_RS21930	COG0515	serine threonine protein kinase
HYQ63_RS21960	COG0705	Rhomboid family
HYQ63_RS21975	COG3764	Sortase (surface protein transpeptidase)
HYQ63_RS21990	COG3764	Sortase (surface protein transpeptidase)
HYQ63_RS21995	COG3764	Sortase (surface protein transpeptidase)
HYQ63_RS22000	COG0515	serine threonine protein kinase
HYQ63_RS22005	COG0768	penicillin binding
HYQ63_RS22020	COG1716	ATPase activity
HYQ63_RS22025	COG1716	ATPase activity
HYQ63_RS22035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HYQ63_RS22040	COG1733	regulation of RNA biosynthetic process
HYQ63_RS22065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYQ63_RS22070	COG2151	metal-sulfur cluster biosynthetic enzyme
HYQ63_RS22075	COG3396	Phenylacetate-CoA oxygenase
HYQ63_RS22080	COG3460	Phenylacetate-CoA oxygenase
HYQ63_RS22085	COG3396	Phenylacetate-CoA oxygenase
HYQ63_RS22100	COG1595	DNA-templated transcription, initiation
HYQ63_RS22105	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYQ63_RS22105	COG1902	pentaerythritol trinitrate reductase activity
HYQ63_RS22120	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYQ63_RS22125	COG1309	transcriptional regulator
HYQ63_RS22130	COG1522	sequence-specific DNA binding
HYQ63_RS22160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYQ63_RS22165	COG0604	alcohol dehydrogenase
HYQ63_RS22165	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS22165	COG3321	synthase
HYQ63_RS22180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYQ63_RS22185	COG0515	serine threonine protein kinase
HYQ63_RS22190	COG0515	serine threonine protein kinase
HYQ63_RS22210	COG0022	dehydrogenase e1 component
HYQ63_RS22215	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYQ63_RS22260	COG1362	aminopeptidase activity
HYQ63_RS22275	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS22285	COG1741	Belongs to the pirin family
HYQ63_RS22295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYQ63_RS22315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYQ63_RS22345	COG1793	dna ligase
HYQ63_RS22355	COG3290	protein histidine kinase activity
HYQ63_RS22415	COG0640	Transcriptional regulator
HYQ63_RS22440	COG0367	asparagine synthase
HYQ63_RS22445	COG0243	molybdopterin cofactor binding
HYQ63_RS22455	COG0725	ABC transporter, periplasmic molybdate-binding protein
HYQ63_RS22475	COG0604	alcohol dehydrogenase
HYQ63_RS22485	COG0583	DNA-binding transcription factor activity
HYQ63_RS22525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYQ63_RS22530	COG0254	rRNA binding
HYQ63_RS22540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYQ63_RS22545	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYQ63_RS22545	COG0515	serine threonine protein kinase
HYQ63_RS22575	COG4326	sporulation control protein
HYQ63_RS22590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYQ63_RS22595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYQ63_RS22600	COG0076	glutamate decarboxylase activity
HYQ63_RS22640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYQ63_RS22680	COG0513	Belongs to the DEAD box helicase family
HYQ63_RS22685	COG1278	Cold shock
HYQ63_RS22695	COG1278	Cold shock
HYQ63_RS22775	COG2188	Transcriptional regulator
HYQ63_RS22845	COG0717	Belongs to the dCTP deaminase family
HYQ63_RS22850	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HYQ63_RS22865	COG3290	protein histidine kinase activity
HYQ63_RS22870	COG2181	nitrate reductase activity
HYQ63_RS22870	COG0247	lactate metabolic process
HYQ63_RS22875	COG0443	Heat shock 70 kDa protein
HYQ63_RS22880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYQ63_RS22885	COG0484	heat shock protein binding
HYQ63_RS22890	COG0789	Transcriptional regulator
HYQ63_RS22910	COG0542	response to heat
HYQ63_RS22935	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYQ63_RS22950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYQ63_RS22955	COG0191	fructose-bisphosphate aldolase activity
HYQ63_RS22960	COG0477	Major facilitator Superfamily
HYQ63_RS22970	COG3483	tryptophan 2,3-dioxygenase activity
HYQ63_RS22975	COG3844	kynureninase activity
HYQ63_RS22990	COG2197	response regulator
HYQ63_RS22995	COG2124	cytochrome p450
HYQ63_RS23005	COG1131	(ABC) transporter
HYQ63_RS23020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYQ63_RS23025	COG0515	serine threonine protein kinase
HYQ63_RS23025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYQ63_RS23050	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS23065	COG1802	Transcriptional regulator
HYQ63_RS23080	COG0151	Belongs to the GarS family
HYQ63_RS23100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYQ63_RS23110	COG2197	response regulator
HYQ63_RS23125	COG1131	(ABC) transporter
HYQ63_RS23145	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYQ63_RS23150	COG0047	phosphoribosylformylglycinamidine synthase activity
HYQ63_RS23155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYQ63_RS23170	COG3119	arylsulfatase activity
HYQ63_RS23180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYQ63_RS23190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYQ63_RS23215	COG1643	Atp-dependent helicase
HYQ63_RS23255	COG1280	lysine exporter protein (LysE YggA)
HYQ63_RS23260	COG3739	integral membrane protein
HYQ63_RS23290	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS23315	COG0513	Belongs to the DEAD box helicase family
HYQ63_RS23360	COG0739	heme binding
HYQ63_RS23360	COG0741	lytic transglycosylase activity
HYQ63_RS23360	COG1196	nuclear chromosome segregation
HYQ63_RS23365	COG0667	Aldo Keto reductase
HYQ63_RS23425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYQ63_RS23430	COG0579	oxidoreductase
HYQ63_RS23455	COG1252	NADH dehydrogenase
HYQ63_RS23470	COG1846	Transcriptional regulator
HYQ63_RS23525	COG0739	heme binding
HYQ63_RS23525	COG1196	nuclear chromosome segregation
HYQ63_RS23525	COG0741	lytic transglycosylase activity
HYQ63_RS23530	COG0671	phosphoesterase, PA-phosphatase related
HYQ63_RS23535	COG0277	FAD linked oxidase domain protein
HYQ63_RS23550	COG1937	Protein conserved in bacteria
HYQ63_RS23560	COG0306	phosphate transporter
HYQ63_RS23565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYQ63_RS23610	COG1309	transcriptional regulator
HYQ63_RS23615	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS23620	COG0667	Aldo Keto reductase
HYQ63_RS23625	COG0604	alcohol dehydrogenase
HYQ63_RS23625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYQ63_RS23625	COG3321	synthase
HYQ63_RS23625	COG4221	oxidoreductase activity
HYQ63_RS23630	COG2267	carboxylic ester hydrolase activity
HYQ63_RS23650	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYQ63_RS23665	COG4552	Acetyltransferase involved in intracellular survival and related
HYQ63_RS23675	COG1490	D-aminoacyl-tRNA deacylase activity
HYQ63_RS23680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYQ63_RS23685	COG0735	belongs to the Fur family
HYQ63_RS23690	COG3485	protocatechuate 3,4-dioxygenase
HYQ63_RS23710	COG2897	thiosulfate sulfurtransferase activity
HYQ63_RS23745	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS23750	COG1609	Transcriptional regulator
HYQ63_RS23755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYQ63_RS23760	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS23785	COG1132	(ABC) transporter
HYQ63_RS23790	COG1132	(ABC) transporter
HYQ63_RS23825	COG3629	intracellular signal transduction
HYQ63_RS23825	COG3903	Transcriptional regulator
HYQ63_RS23830	COG1132	(ABC) transporter
HYQ63_RS23840	COG0724	RNA recognition motif
HYQ63_RS23850	COG0789	Transcriptional regulator
HYQ63_RS23880	COG1196	nuclear chromosome segregation
HYQ63_RS23880	COG0741	lytic transglycosylase activity
HYQ63_RS23880	COG0739	heme binding
HYQ63_RS23895	COG2205	protein histidine kinase activity
HYQ63_RS23900	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS23910	COG1595	DNA-templated transcription, initiation
HYQ63_RS23915	COG1194	a g-specific adenine glycosylase
HYQ63_RS23925	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HYQ63_RS23945	COG0248	Ppx GppA phosphatase
HYQ63_RS23950	COG1082	Xylose isomerase domain protein TIM barrel
HYQ63_RS23960	COG0129	dihydroxy-acid dehydratase activity
HYQ63_RS23965	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYQ63_RS23965	COG0515	serine threonine protein kinase
HYQ63_RS23985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYQ63_RS23990	COG0180	Tryptophanyl-tRNA synthetase
HYQ63_RS24010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYQ63_RS24020	COG0123	including yeast histone deacetylase and acetoin utilization protein
HYQ63_RS24070	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYQ63_RS24075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HYQ63_RS24080	COG0181	hydroxymethylbilane synthase activity
HYQ63_RS24085	COG1648	precorrin-2 dehydrogenase activity
HYQ63_RS24085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HYQ63_RS24090	COG0113	porphobilinogen synthase activity
HYQ63_RS24105	COG1072	(Pantothenic acid kinase))
HYQ63_RS24140	COG0018	arginyl-trna synthetase
HYQ63_RS24145	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HYQ63_RS24165	COG1690	Belongs to the RtcB family
HYQ63_RS24180	COG1742	UPF0060 membrane protein
HYQ63_RS24190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYQ63_RS24195	COG0406	alpha-ribazole phosphatase activity
HYQ63_RS24215	COG1333	cytochrome c biogenesis protein
HYQ63_RS24220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYQ63_RS24230	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HYQ63_RS24235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HYQ63_RS24240	COG0163	prenyltransferase activity
HYQ63_RS24255	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HYQ63_RS24260	COG1573	uracil-dna glycosylase
HYQ63_RS24275	COG1301	dicarboxylic acid transport
HYQ63_RS24335	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HYQ63_RS24345	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HYQ63_RS24355	COG2226	methyltransferase
HYQ63_RS24380	COG3103	Sh3 type 3 domain protein
HYQ63_RS24380	COG1388	LysM domain
HYQ63_RS24380	COG0791	NLP P60 protein
HYQ63_RS24390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYQ63_RS24395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYQ63_RS24400	COG0649	NAD binding
HYQ63_RS24410	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HYQ63_RS24415	COG1034	ATP synthesis coupled electron transport
HYQ63_RS24420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYQ63_RS24425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYQ63_RS24430	COG0839	Belongs to the complex I subunit 6 family
HYQ63_RS24435	COG0713	ATP synthesis coupled electron transport
HYQ63_RS24440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYQ63_RS24450	COG1007	ATP synthesis coupled electron transport
HYQ63_RS24470	COG0492	ferredoxin-NADP+ reductase activity
HYQ63_RS24505	COG0702	epimerase
HYQ63_RS24510	COG1733	regulation of RNA biosynthetic process
HYQ63_RS24515	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYQ63_RS24520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYQ63_RS24520	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYQ63_RS24525	COG2197	response regulator
HYQ63_RS24530	COG4585	Histidine kinase
HYQ63_RS24535	COG4585	Histidine kinase
HYQ63_RS24540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYQ63_RS24545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYQ63_RS24550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYQ63_RS24555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYQ63_RS24560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYQ63_RS24565	COG0839	Belongs to the complex I subunit 6 family
HYQ63_RS24570	COG0713	ATP synthesis coupled electron transport
HYQ63_RS24575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYQ63_RS24585	COG1007	ATP synthesis coupled electron transport
HYQ63_RS24590	COG0501	Belongs to the peptidase M48B family
HYQ63_RS24595	COG3304	Inner membrane component domain
HYQ63_RS24610	COG1666	GTP binding
HYQ63_RS24620	COG2188	Transcriptional regulator
HYQ63_RS24635	COG2319	Wd-40 repeat
HYQ63_RS24635	COG4249	Peptidase C14 caspase catalytic subunit p20
HYQ63_RS24645	COG0702	epimerase
HYQ63_RS24650	COG0402	S-adenosylhomocysteine deaminase activity
HYQ63_RS24665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYQ63_RS24670	COG2030	dehydratase
HYQ63_RS24680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYQ63_RS24685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYQ63_RS24690	COG0436	Aminotransferase
HYQ63_RS24710	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYQ63_RS24715	COG0081	regulation of translation
HYQ63_RS24725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYQ63_RS24730	COG0222	ribosome binding
HYQ63_RS24735	COG0085	RNA polymerase activity
HYQ63_RS24740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYQ63_RS24745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYQ63_RS24750	COG0049	tRNA binding
HYQ63_RS24755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYQ63_RS24760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYQ63_RS24790	COG1595	DNA-templated transcription, initiation
HYQ63_RS24800	COG0051	transcription antitermination factor activity, RNA binding
HYQ63_RS24805	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYQ63_RS24810	COG0088	Forms part of the polypeptide exit tunnel
HYQ63_RS24815	COG0089	rRNA binding
HYQ63_RS24820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYQ63_RS24825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYQ63_RS24830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYQ63_RS24835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYQ63_RS24840	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYQ63_RS24845	COG0255	Belongs to the universal ribosomal protein uL29 family
HYQ63_RS24850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYQ63_RS24855	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYQ63_RS24860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYQ63_RS24865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYQ63_RS24870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYQ63_RS24875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYQ63_RS24880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYQ63_RS24885	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYQ63_RS24890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYQ63_RS24900	COG0200	Binds to the 23S rRNA
HYQ63_RS24910	COG0563	adenylate kinase activity
HYQ63_RS24920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYQ63_RS24925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYQ63_RS24930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYQ63_RS24935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYQ63_RS24940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYQ63_RS24945	COG0202	RNA polymerase activity
HYQ63_RS24950	COG0203	ribosomal protein L17
HYQ63_RS24955	COG0101	tRNA pseudouridine synthase activity
HYQ63_RS24960	COG1366	Belongs to the anti-sigma-factor antagonist family
HYQ63_RS24965	COG1366	Belongs to the anti-sigma-factor antagonist family
HYQ63_RS24970	COG2172	sigma factor antagonist activity
HYQ63_RS24980	COG2770	Histidine kinase
HYQ63_RS24980	COG2208	phosphoserine phosphatase activity
HYQ63_RS24990	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS25040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYQ63_RS25045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYQ63_RS25050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYQ63_RS25060	COG1072	(Pantothenic acid kinase))
HYQ63_RS25065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYQ63_RS25070	COG0736	holo-[acyl-carrier-protein] synthase activity
HYQ63_RS25105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYQ63_RS25115	COG0802	atpase or kinase
HYQ63_RS25140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYQ63_RS25180	COG0726	polysaccharide deacetylase
HYQ63_RS25185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYQ63_RS25190	COG0459	protein refolding
HYQ63_RS25200	COG0583	DNA-binding transcription factor activity
HYQ63_RS25210	COG2197	response regulator
HYQ63_RS25215	COG1595	DNA-templated transcription, initiation
HYQ63_RS25225	COG0516	GMP reductase activity
HYQ63_RS25240	COG1077	Cell shape determining protein MreB Mrl
HYQ63_RS25255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HYQ63_RS25275	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS25280	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS25285	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS25300	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS25305	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS25310	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS25330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYQ63_RS25335	COG1024	Enoyl-CoA hydratase
HYQ63_RS25345	COG2072	flavoprotein involved in K transport
HYQ63_RS25360	COG2018	Roadblock/LC7 domain
HYQ63_RS25385	COG0259	pyridoxamine-phosphate oxidase activity
HYQ63_RS25395	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS25405	COG1309	transcriptional regulator
HYQ63_RS25415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYQ63_RS25415	COG0515	serine threonine protein kinase
HYQ63_RS25425	COG1024	Enoyl-CoA hydratase
HYQ63_RS25470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS25490	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS25510	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYQ63_RS25515	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS25565	COG1301	dicarboxylic acid transport
HYQ63_RS25590	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HYQ63_RS25600	COG0640	Transcriptional regulator
HYQ63_RS25675	COG1686	Belongs to the peptidase S11 family
HYQ63_RS25685	COG1653	transport
HYQ63_RS25695	COG0515	serine threonine protein kinase
HYQ63_RS25790	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYQ63_RS25795	COG1793	dna ligase
HYQ63_RS25795	COG3285	dna ligase
HYQ63_RS25805	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYQ63_RS25815	COG1316	TRANSCRIPTIONal
HYQ63_RS25820	COG0824	Thioesterase
HYQ63_RS25820	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYQ63_RS25825	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYQ63_RS25830	COG3246	L-lysine catabolic process to acetate
HYQ63_RS25850	COG0515	serine threonine protein kinase
HYQ63_RS25860	COG2197	response regulator
HYQ63_RS25870	COG0464	growth
HYQ63_RS26030	COG1309	transcriptional regulator
HYQ63_RS26050	COG1301	dicarboxylic acid transport
HYQ63_RS26065	COG0583	DNA-binding transcription factor activity
HYQ63_RS26095	COG0640	Transcriptional regulator
HYQ63_RS26100	COG0346	lactoylglutathione lyase activity
HYQ63_RS26120	COG0789	Transcriptional regulator
HYQ63_RS26180	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HYQ63_RS26185	COG0076	glutamate decarboxylase activity
HYQ63_RS26225	COG1309	transcriptional regulator
HYQ63_RS26245	COG1846	Transcriptional regulator
HYQ63_RS26250	COG3384	dioxygenase
HYQ63_RS26265	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS26270	COG1349	DNA-binding transcription factor activity
HYQ63_RS26275	COG1105	Belongs to the carbohydrate kinase PfkB family
HYQ63_RS26295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYQ63_RS26305	COG1970	mechanosensitive ion channel activity
HYQ63_RS26315	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HYQ63_RS26325	COG3263	regulation of cellular component size
HYQ63_RS26335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYQ63_RS26340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYQ63_RS26350	COG0315	cyclic pyranopterin monophosphate synthase activity
HYQ63_RS26355	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYQ63_RS26355	COG0315	cyclic pyranopterin monophosphate synthase activity
HYQ63_RS26360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYQ63_RS26400	COG0708	Exodeoxyribonuclease III
HYQ63_RS26405	COG0789	Transcriptional regulator
HYQ63_RS26410	COG2072	flavoprotein involved in K transport
HYQ63_RS26430	COG4946	Tricorn protease homolog
HYQ63_RS26430	COG0793	Belongs to the peptidase S41A family
HYQ63_RS26440	COG2409	Drug exporters of the RND superfamily
HYQ63_RS26445	COG0310	cobalt ion transport
HYQ63_RS26455	COG1122	ATPase activity
HYQ63_RS26480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYQ63_RS26495	COG3629	intracellular signal transduction
HYQ63_RS26495	COG3903	Transcriptional regulator
HYQ63_RS26505	COG0768	penicillin binding
HYQ63_RS26525	COG0084	hydrolase, TatD family'
HYQ63_RS26535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYQ63_RS26540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYQ63_RS26545	COG0488	(ABC) transporter
HYQ63_RS26580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYQ63_RS26585	COG2197	response regulator
HYQ63_RS26595	COG4106	trans-aconitate 2-methyltransferase activity
HYQ63_RS26600	COG1309	transcriptional regulator
HYQ63_RS26610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HYQ63_RS26620	COG0193	aminoacyl-tRNA hydrolase activity
HYQ63_RS26625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYQ63_RS26630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYQ63_RS26635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYQ63_RS26645	COG4585	Histidine kinase
HYQ63_RS26675	COG2814	Major facilitator Superfamily
HYQ63_RS26680	COG1136	(ABC) transporter
HYQ63_RS26685	COG1136	(ABC) transporter
HYQ63_RS26685	COG0577	efflux transmembrane transporter activity
HYQ63_RS26695	COG0667	Aldo Keto reductase
HYQ63_RS26710	COG0346	lactoylglutathione lyase activity
HYQ63_RS26830	COG1396	sequence-specific DNA binding
HYQ63_RS26835	COG0740	serine-type endopeptidase activity
HYQ63_RS26840	COG0740	serine-type endopeptidase activity
HYQ63_RS26865	COG5002	protein histidine kinase activity
HYQ63_RS26870	COG2018	Roadblock/LC7 domain
HYQ63_RS26890	COG0640	Transcriptional regulator
HYQ63_RS26895	COG1234	tRNA 3'-trailer cleavage
HYQ63_RS26930	COG0667	Aldo Keto reductase
HYQ63_RS26980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYQ63_RS27000	COG1595	DNA-templated transcription, initiation
HYQ63_RS27010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYQ63_RS27025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYQ63_RS27035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYQ63_RS27055	COG2814	Major facilitator Superfamily
HYQ63_RS27065	COG0154	amidase activity
HYQ63_RS27075	COG1331	Highly conserved protein containing a thioredoxin domain
HYQ63_RS27085	COG1272	protein, Hemolysin III
HYQ63_RS27090	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HYQ63_RS27100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HYQ63_RS27120	COG0601	transmembrane transport
HYQ63_RS27155	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HYQ63_RS27170	COG1414	Transcriptional regulator
HYQ63_RS27180	COG2610	gluconate transmembrane transporter activity
HYQ63_RS27205	COG2894	cell division
HYQ63_RS27245	COG2885	chlorophyll binding
HYQ63_RS27250	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HYQ63_RS27260	COG1278	Cold shock
HYQ63_RS27275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYQ63_RS27280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYQ63_RS27295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYQ63_RS27300	COG0450	alkyl hydroperoxide reductase
HYQ63_RS27315	COG1136	(ABC) transporter
HYQ63_RS27335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYQ63_RS27345	COG2226	methyltransferase
HYQ63_RS27355	COG0114	fumarate hydratase activity
HYQ63_RS27370	COG3979	chitinase
HYQ63_RS27375	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HYQ63_RS27375	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HYQ63_RS27400	COG0778	Nitroreductase
HYQ63_RS27405	COG1722	exodeoxyribonuclease VII activity
HYQ63_RS27410	COG1570	exodeoxyribonuclease VII activity
HYQ63_RS27415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYQ63_RS27430	COG0012	GTP binding
HYQ63_RS27445	COG0515	serine threonine protein kinase
HYQ63_RS27450	COG1132	(ABC) transporter
HYQ63_RS27455	COG1132	(ABC) transporter
HYQ63_RS27460	COG2197	response regulator
HYQ63_RS27485	COG0531	amino acid
HYQ63_RS27515	COG1053	succinate dehydrogenase
HYQ63_RS27545	COG0601	transmembrane transport
HYQ63_RS27550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYQ63_RS27555	COG0444	Belongs to the ABC transporter superfamily
HYQ63_RS27560	COG4608	Belongs to the ABC transporter superfamily
HYQ63_RS27565	COG1653	transport
HYQ63_RS27570	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS27575	COG4209	transmembrane transport
HYQ63_RS27580	COG4166	transmembrane transport
HYQ63_RS27585	COG0601	transmembrane transport
HYQ63_RS27600	COG4608	Belongs to the ABC transporter superfamily
HYQ63_RS27615	COG4977	sequence-specific DNA binding
HYQ63_RS27655	COG0640	Transcriptional regulator
HYQ63_RS27665	COG4608	Belongs to the ABC transporter superfamily
HYQ63_RS27670	COG0444	Belongs to the ABC transporter superfamily
HYQ63_RS27680	COG0747	negative chemotaxis
HYQ63_RS27685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYQ63_RS27705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYQ63_RS27720	COG1131	(ABC) transporter
HYQ63_RS27730	COG4585	Histidine kinase
HYQ63_RS27735	COG2197	response regulator
HYQ63_RS27770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYQ63_RS27775	COG1611	Belongs to the LOG family
HYQ63_RS27780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYQ63_RS27790	COG0519	Catalyzes the synthesis of GMP from XMP
HYQ63_RS27795	COG1024	Enoyl-CoA hydratase
HYQ63_RS27810	COG1595	DNA-templated transcription, initiation
HYQ63_RS27820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYQ63_RS27825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYQ63_RS27865	COG0598	Magnesium transport protein CorA
HYQ63_RS27880	COG0613	PHP domain protein
HYQ63_RS27890	COG1432	Conserved Protein
HYQ63_RS27895	COG0596	Alpha beta hydrolase
HYQ63_RS27900	COG0513	Belongs to the DEAD box helicase family
HYQ63_RS27990	COG0210	DNA helicase
HYQ63_RS27995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYQ63_RS28030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYQ63_RS28085	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYQ63_RS28095	COG1615	UPF0182 protein
HYQ63_RS28120	COG0753	catalase activity
HYQ63_RS28130	COG0483	inositol monophosphate 1-phosphatase activity
HYQ63_RS28140	COG2076	Multidrug Resistance protein
HYQ63_RS28150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYQ63_RS28160	COG2135	peptidase activity
HYQ63_RS28170	COG1595	DNA-templated transcription, initiation
HYQ63_RS28175	COG5662	AntiSigma factor
HYQ63_RS28180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HYQ63_RS28180	COG2199	diguanylate cyclase activity
HYQ63_RS28195	COG0242	peptide deformylase activity
HYQ63_RS28200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYQ63_RS28215	COG0588	phosphoglycerate mutase activity
HYQ63_RS28220	COG1349	DNA-binding transcription factor activity
HYQ63_RS28260	COG2188	Transcriptional regulator
HYQ63_RS28265	COG1472	Belongs to the glycosyl hydrolase 3 family
HYQ63_RS28270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYQ63_RS28285	COG1597	lipid kinase activity
HYQ63_RS28325	COG2066	Belongs to the glutaminase family
HYQ63_RS28345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYQ63_RS28370	COG5640	endopeptidase activity
HYQ63_RS28375	COG0583	DNA-binding transcription factor activity
HYQ63_RS28410	COG1126	abc transporter atp-binding protein
HYQ63_RS28415	COG0765	amino acid transport
HYQ63_RS28425	COG0281	malic enzyme
HYQ63_RS28430	COG0604	alcohol dehydrogenase
HYQ63_RS28455	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS28455	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS28455	COG3321	synthase
HYQ63_RS28455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYQ63_RS28455	COG0300	oxidoreductase activity
HYQ63_RS28470	COG0778	Nitroreductase
HYQ63_RS28490	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS28500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYQ63_RS28510	COG0567	Dehydrogenase, E1 component
HYQ63_RS28510	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYQ63_RS28515	COG2205	protein histidine kinase activity
HYQ63_RS28520	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS28535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYQ63_RS28540	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYQ63_RS28590	COG0791	NLP P60 protein
HYQ63_RS28640	COG0583	DNA-binding transcription factor activity
HYQ63_RS28645	COG2814	Major facilitator Superfamily
HYQ63_RS28655	COG0477	Major facilitator Superfamily
HYQ63_RS28715	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS28720	COG0018	arginyl-trna synthetase
HYQ63_RS28725	COG0019	diaminopimelate decarboxylase activity
HYQ63_RS28730	COG0460	homoserine dehydrogenase
HYQ63_RS28735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYQ63_RS28740	COG0083	homoserine kinase activity
HYQ63_RS28750	COG1316	TRANSCRIPTIONal
HYQ63_RS28755	COG0254	rRNA binding
HYQ63_RS28760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYQ63_RS28765	COG2890	protein-(glutamine-N5) methyltransferase activity
HYQ63_RS28775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYQ63_RS28780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYQ63_RS28800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS28805	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYQ63_RS28840	COG1819	glycosyl
HYQ63_RS28850	COG1819	glycosyl
HYQ63_RS28895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS28925	COG0019	diaminopimelate decarboxylase activity
HYQ63_RS28940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYQ63_RS28955	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYQ63_RS28960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HYQ63_RS28965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYQ63_RS28970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYQ63_RS28975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYQ63_RS28980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYQ63_RS28985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HYQ63_RS28995	COG2197	response regulator
HYQ63_RS29000	COG4585	Histidine kinase
HYQ63_RS29030	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYQ63_RS29045	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HYQ63_RS29095	COG0183	Belongs to the thiolase family
HYQ63_RS29105	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS29160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYQ63_RS29160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYQ63_RS29200	COG0542	response to heat
HYQ63_RS29210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYQ63_RS29215	COG0857	belongs to the CobB CobQ family
HYQ63_RS29215	COG0280	phosphate acetyltransferase
HYQ63_RS29220	COG0205	6-phosphofructokinase activity
HYQ63_RS29235	COG3833	ABC-type maltose transport systems, permease component
HYQ63_RS29240	COG1316	TRANSCRIPTIONal
HYQ63_RS29255	COG1595	DNA-templated transcription, initiation
HYQ63_RS29260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYQ63_RS29280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYQ63_RS29385	COG1175	transmembrane transport
HYQ63_RS29395	COG3469	chitinase activity
HYQ63_RS29400	COG4565	transcriptional regulatory protein
HYQ63_RS29405	COG5000	phosphorelay sensor kinase activity
HYQ63_RS29410	COG1301	dicarboxylic acid transport
HYQ63_RS29420	COG3903	Transcriptional regulator
HYQ63_RS29420	COG3629	intracellular signal transduction
HYQ63_RS29430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYQ63_RS29435	COG3281	Trehalose synthase
HYQ63_RS29445	COG0366	Alpha amylase catalytic
HYQ63_RS29455	COG5297	Belongs to the glycosyl hydrolase family 6
HYQ63_RS29465	COG3401	FG-GAP repeat protein
HYQ63_RS29470	COG0058	SHG alpha-glucan phosphorylase activity
HYQ63_RS29475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYQ63_RS29500	COG1132	(ABC) transporter
HYQ63_RS29505	COG1132	(ABC) transporter
HYQ63_RS29515	COG1376	ErfK ybiS ycfS ynhG family protein
HYQ63_RS29560	COG2255	four-way junction helicase activity
HYQ63_RS29570	COG1760	l-serine dehydratase
HYQ63_RS29575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYQ63_RS29580	COG0509	glycine decarboxylation via glycine cleavage system
HYQ63_RS29585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYQ63_RS29610	COG4166	transmembrane transport
HYQ63_RS29620	COG0444	Belongs to the ABC transporter superfamily
HYQ63_RS29625	COG4608	Belongs to the ABC transporter superfamily
HYQ63_RS29630	COG2860	membrane
HYQ63_RS29665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS29670	COG0482	sulfurtransferase activity
HYQ63_RS29730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYQ63_RS29740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYQ63_RS29745	COG0154	amidase activity
HYQ63_RS29755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYQ63_RS29765	COG0747	negative chemotaxis
HYQ63_RS29775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYQ63_RS29785	COG3511	phospholipase C
HYQ63_RS29790	COG2409	Drug exporters of the RND superfamily
HYQ63_RS29800	COG2133	pyrroloquinoline quinone binding
HYQ63_RS29805	COG0667	Aldo Keto reductase
HYQ63_RS29825	COG0440	acetolactate synthase activity
HYQ63_RS29830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYQ63_RS29875	COG0506	proline dehydrogenase activity
HYQ63_RS29880	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS29890	COG0473	3-isopropylmalate dehydrogenase activity
HYQ63_RS29895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYQ63_RS29900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYQ63_RS29905	COG2353	YceI-like domain
HYQ63_RS29915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYQ63_RS29935	COG2018	Roadblock/LC7 domain
HYQ63_RS29955	COG2018	Roadblock/LC7 domain
HYQ63_RS29960	COG5002	protein histidine kinase activity
HYQ63_RS29970	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYQ63_RS29975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYQ63_RS30015	COG1414	Transcriptional regulator
HYQ63_RS30020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYQ63_RS30025	COG0066	3-isopropylmalate dehydratase activity
HYQ63_RS30035	COG0776	regulation of translation
HYQ63_RS30045	COG1920	GTP binding
HYQ63_RS30055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYQ63_RS30060	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYQ63_RS30080	COG0351	phosphomethylpyrimidine kinase
HYQ63_RS30085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYQ63_RS30090	COG1461	Dihydroxyacetone kinase
HYQ63_RS30100	COG0742	ribosomal rna small subunit methyltransferase
HYQ63_RS30105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYQ63_RS30120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYQ63_RS30125	COG0571	ribonuclease III activity
HYQ63_RS30130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYQ63_RS30135	COG1733	regulation of RNA biosynthetic process
HYQ63_RS30145	COG1254	Belongs to the acylphosphatase family
HYQ63_RS30155	COG1196	nuclear chromosome segregation
HYQ63_RS30160	COG0477	Major facilitator Superfamily
HYQ63_RS30180	COG4585	Histidine kinase
HYQ63_RS30185	COG2197	response regulator
HYQ63_RS30215	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HYQ63_RS30230	COG0442	prolyl-tRNA aminoacylation
HYQ63_RS30240	COG0228	four-way junction DNA binding
HYQ63_RS30245	COG1837	Belongs to the UPF0109 family
HYQ63_RS30250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYQ63_RS30255	COG0336	Belongs to the RNA methyltransferase TrmD family
HYQ63_RS30260	COG0335	large ribosomal subunit rRNA binding
HYQ63_RS30275	COG0681	Belongs to the peptidase S26 family
HYQ63_RS30280	COG0681	Belongs to the peptidase S26 family
HYQ63_RS30285	COG1051	belongs to the nudix hydrolase family
HYQ63_RS30295	COG0792	nuclease activity
HYQ63_RS30330	COG1191	sigma factor activity
HYQ63_RS30345	COG0052	Belongs to the universal ribosomal protein uS2 family
HYQ63_RS30350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYQ63_RS30355	COG0528	UMP kinase activity
HYQ63_RS30360	COG0233	cytoplasmic translational termination
HYQ63_RS30365	COG0575	Belongs to the CDS family
HYQ63_RS30370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYQ63_RS30385	COG3842	ATPase activity
HYQ63_RS30400	COG1136	(ABC) transporter
HYQ63_RS30405	COG0028	Belongs to the TPP enzyme family
HYQ63_RS30420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYQ63_RS30430	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS30440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYQ63_RS30455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HYQ63_RS30460	COG3842	ATPase activity
HYQ63_RS30465	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYQ63_RS30470	COG1177	transmembrane transport
HYQ63_RS30475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYQ63_RS30495	COG2508	Transcriptional regulator
HYQ63_RS30500	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS30505	COG1472	Belongs to the glycosyl hydrolase 3 family
HYQ63_RS30520	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS30540	COG1609	Transcriptional regulator
HYQ63_RS30550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYQ63_RS30555	COG0750	zinc metalloprotease
HYQ63_RS30560	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYQ63_RS30575	COG0442	prolyl-tRNA aminoacylation
HYQ63_RS30595	COG0779	Required for maturation of 30S ribosomal subunits
HYQ63_RS30610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYQ63_RS30620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYQ63_RS30625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYQ63_RS30635	COG0455	bacterial-type flagellum organization
HYQ63_RS30650	COG3266	domain, Protein
HYQ63_RS30655	COG1404	Belongs to the peptidase S8 family
HYQ63_RS30705	COG1674	ftsk spoiiie
HYQ63_RS30735	COG1404	Belongs to the peptidase S8 family
HYQ63_RS30795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYQ63_RS30795	COG0515	serine threonine protein kinase
HYQ63_RS30810	COG0154	amidase activity
HYQ63_RS30815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYQ63_RS30820	COG1185	polyribonucleotide nucleotidyltransferase activity
HYQ63_RS30825	COG0612	Peptidase, M16
HYQ63_RS30830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYQ63_RS30850	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HYQ63_RS30855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYQ63_RS30860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYQ63_RS30890	COG2770	Histidine kinase
HYQ63_RS30890	COG2208	phosphoserine phosphatase activity
HYQ63_RS30895	COG4999	Histidine kinase
HYQ63_RS30895	COG2205	protein histidine kinase activity
HYQ63_RS30895	COG3437	response regulator, receiver
HYQ63_RS30895	COG3850	Histidine kinase
HYQ63_RS30905	COG1674	ftsk spoiiie
HYQ63_RS30915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYQ63_RS30925	COG1058	Belongs to the CinA family
HYQ63_RS30925	COG1546	Belongs to the CinA family
HYQ63_RS30930	COG1396	sequence-specific DNA binding
HYQ63_RS30940	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS30945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYQ63_RS30950	COG1201	RNA secondary structure unwinding
HYQ63_RS30970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYQ63_RS30995	COG0765	amino acid transport
HYQ63_RS31000	COG0765	amino acid transport
HYQ63_RS31005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYQ63_RS31010	COG1126	abc transporter atp-binding protein
HYQ63_RS31020	COG2205	protein histidine kinase activity
HYQ63_RS31030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYQ63_RS31050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYQ63_RS31060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYQ63_RS31065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYQ63_RS31075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYQ63_RS31110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYQ63_RS31115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYQ63_RS31120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYQ63_RS31135	COG0488	(ABC) transporter
HYQ63_RS31150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYQ63_RS31200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYQ63_RS31205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYQ63_RS31255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYQ63_RS31260	COG2186	Transcriptional regulator
HYQ63_RS31265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYQ63_RS31280	COG0187	DNA topoisomerase II activity
HYQ63_RS31290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYQ63_RS31295	COG4565	transcriptional regulatory protein
HYQ63_RS31300	COG3290	protein histidine kinase activity
HYQ63_RS31315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYQ63_RS31320	COG0612	Peptidase, M16
HYQ63_RS31335	COG1802	Transcriptional regulator
HYQ63_RS31340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYQ63_RS31360	COG1435	thymidine kinase activity
HYQ63_RS31395	COG0483	inositol monophosphate 1-phosphatase activity
HYQ63_RS31405	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS31410	COG2205	protein histidine kinase activity
HYQ63_RS31435	COG0756	dUTP diphosphatase activity
HYQ63_RS31455	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HYQ63_RS31460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HYQ63_RS31465	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HYQ63_RS31495	COG0569	domain protein
HYQ63_RS31525	COG0531	amino acid
HYQ63_RS31530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYQ63_RS31565	COG2040	homocysteine
HYQ63_RS31575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYQ63_RS31605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYQ63_RS31615	COG1024	Enoyl-CoA hydratase
HYQ63_RS31620	COG1902	pentaerythritol trinitrate reductase activity
HYQ63_RS31645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYQ63_RS31680	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS31695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYQ63_RS31700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYQ63_RS31730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYQ63_RS31755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYQ63_RS31770	COG1653	transport
HYQ63_RS31775	COG1175	transmembrane transport
HYQ63_RS31780	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS31790	COG4213	ABC transporter substrate-binding protein
HYQ63_RS31800	COG4214	carbohydrate transport
HYQ63_RS31805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYQ63_RS31810	COG0531	amino acid
HYQ63_RS31825	COG1024	Enoyl-CoA hydratase
HYQ63_RS31825	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYQ63_RS31830	COG0183	Belongs to the thiolase family
HYQ63_RS31850	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYQ63_RS31855	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYQ63_RS31860	COG2271	Major facilitator Superfamily
HYQ63_RS31875	COG1414	Transcriptional regulator
HYQ63_RS31900	COG3220	belongs to the UPF0276 family
HYQ63_RS31905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYQ63_RS31945	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS31950	COG5002	protein histidine kinase activity
HYQ63_RS32000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYQ63_RS32005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYQ63_RS32020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYQ63_RS32025	COG0583	DNA-binding transcription factor activity
HYQ63_RS32080	COG1119	ATPase activity
HYQ63_RS32085	COG2188	Transcriptional regulator
HYQ63_RS32150	COG0577	efflux transmembrane transporter activity
HYQ63_RS32150	COG1136	(ABC) transporter
HYQ63_RS32195	COG0243	molybdopterin cofactor binding
HYQ63_RS32200	COG2223	nitrite transmembrane transporter activity
HYQ63_RS32215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYQ63_RS32220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYQ63_RS32220	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS32220	COG3321	synthase
HYQ63_RS32220	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS32220	COG0300	oxidoreductase activity
HYQ63_RS32235	COG1175	transmembrane transport
HYQ63_RS32280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYQ63_RS32285	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HYQ63_RS32305	COG0529	Catalyzes the synthesis of activated sulfate
HYQ63_RS32310	COG0175	sulfate reduction
HYQ63_RS32345	COG3629	intracellular signal transduction
HYQ63_RS32345	COG3903	Transcriptional regulator
HYQ63_RS32355	COG3903	Transcriptional regulator
HYQ63_RS32355	COG3629	intracellular signal transduction
HYQ63_RS32360	COG1162	GTPase activity
HYQ63_RS32365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYQ63_RS32415	COG1802	Transcriptional regulator
HYQ63_RS32440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYQ63_RS32485	COG0598	Magnesium transport protein CorA
HYQ63_RS32495	COG2197	response regulator
HYQ63_RS32500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYQ63_RS32505	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS32560	COG2133	pyrroloquinoline quinone binding
HYQ63_RS32560	COG5183	chlorophyll binding
HYQ63_RS32570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYQ63_RS32580	COG1414	Transcriptional regulator
HYQ63_RS32585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYQ63_RS32590	COG4266	Belongs to the allantoicase family
HYQ63_RS32645	COG0800	Aldolase
HYQ63_RS32685	COG0789	Transcriptional regulator
HYQ63_RS32695	COG1874	Beta-galactosidase
HYQ63_RS32705	COG0601	transmembrane transport
HYQ63_RS32710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYQ63_RS32715	COG0444	Belongs to the ABC transporter superfamily
HYQ63_RS32720	COG4608	Belongs to the ABC transporter superfamily
HYQ63_RS32725	COG2188	Transcriptional regulator
HYQ63_RS32745	COG1940	carbohydrate kinase activity
HYQ63_RS32755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYQ63_RS32785	COG1126	abc transporter atp-binding protein
HYQ63_RS32790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYQ63_RS32795	COG0765	amino acid transport
HYQ63_RS32800	COG0765	amino acid transport
HYQ63_RS32815	COG0405	Gamma-glutamyltransferase
HYQ63_RS32830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYQ63_RS32835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYQ63_RS32850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYQ63_RS32865	COG1846	Transcriptional regulator
HYQ63_RS32865	COG1940	carbohydrate kinase activity
HYQ63_RS32870	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS32875	COG1082	Xylose isomerase domain protein TIM barrel
HYQ63_RS32885	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS32895	COG1129	ABC transporter
HYQ63_RS32900	COG1879	ABC-type sugar transport system periplasmic component
HYQ63_RS32905	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYQ63_RS32915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYQ63_RS32920	COG3958	Transketolase
HYQ63_RS32925	COG3959	Transketolase, thiamine diphosphate binding domain
HYQ63_RS32930	COG0483	inositol monophosphate 1-phosphatase activity
HYQ63_RS32950	COG0181	hydroxymethylbilane synthase activity
HYQ63_RS32985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYQ63_RS33005	COG1929	Belongs to the glycerate kinase type-1 family
HYQ63_RS33015	COG0688	phosphatidylethanolamine metabolic process
HYQ63_RS33020	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS33030	COG2301	Belongs to the HpcH HpaI aldolase family
HYQ63_RS33035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYQ63_RS33035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYQ63_RS33050	COG1082	Xylose isomerase domain protein TIM barrel
HYQ63_RS33055	COG1309	transcriptional regulator
HYQ63_RS33100	COG2362	D-Aminopeptidase
HYQ63_RS33105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYQ63_RS33135	COG2226	methyltransferase
HYQ63_RS33165	COG0693	protein deglycase activity
HYQ63_RS33175	COG0028	Belongs to the TPP enzyme family
HYQ63_RS33180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS33240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS33255	COG0662	Cupin 2, conserved barrel domain protein
HYQ63_RS33275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HYQ63_RS33330	COG2226	methyltransferase
HYQ63_RS33335	COG0596	Alpha beta hydrolase
HYQ63_RS33380	COG1733	regulation of RNA biosynthetic process
HYQ63_RS33410	COG0531	amino acid
HYQ63_RS33435	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS33505	COG2072	flavoprotein involved in K transport
HYQ63_RS33525	COG2130	NADP-dependent
HYQ63_RS33535	COG2409	Drug exporters of the RND superfamily
HYQ63_RS33555	COG2154	pterin-4-alpha-carbinolamine dehydratase
HYQ63_RS33570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYQ63_RS33575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYQ63_RS33595	COG1595	DNA-templated transcription, initiation
HYQ63_RS33600	COG4106	trans-aconitate 2-methyltransferase activity
HYQ63_RS33610	COG0656	L-ascorbic acid biosynthetic process
HYQ63_RS33620	COG1022	Amp-dependent synthetase and ligase
HYQ63_RS33625	COG0583	DNA-binding transcription factor activity
HYQ63_RS33650	COG1846	Transcriptional regulator
HYQ63_RS33655	COG0789	Transcriptional regulator
HYQ63_RS33665	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS33675	COG1309	transcriptional regulator
HYQ63_RS33680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYQ63_RS33695	COG1940	carbohydrate kinase activity
HYQ63_RS33700	COG1129	ABC transporter
HYQ63_RS33705	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYQ63_RS33710	COG4213	ABC transporter substrate-binding protein
HYQ63_RS33715	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS33780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYQ63_RS33790	COG0697	spore germination
HYQ63_RS33820	COG1982	Orn Lys Arg decarboxylase major
HYQ63_RS33830	COG1846	Transcriptional regulator
HYQ63_RS33830	COG1940	carbohydrate kinase activity
HYQ63_RS33840	COG1021	2,3-dihydroxybenzoate-AMP ligase
HYQ63_RS33860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS33865	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS33885	COG0477	Major facilitator Superfamily
HYQ63_RS33900	COG0745	RESPONSE REGULATOR receiver
HYQ63_RS33920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS33920	COG0300	oxidoreductase activity
HYQ63_RS33920	COG3321	synthase
HYQ63_RS33920	COG4221	oxidoreductase activity
HYQ63_RS33935	COG2197	response regulator
HYQ63_RS33960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS33970	COG0431	NADPH-dependent FMN reductase
HYQ63_RS34005	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS34010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYQ63_RS34015	COG1414	Transcriptional regulator
HYQ63_RS34020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYQ63_RS34025	COG1959	2 iron, 2 sulfur cluster binding
HYQ63_RS34045	COG1404	Belongs to the peptidase S8 family
HYQ63_RS34055	COG0531	amino acid
HYQ63_RS34060	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS34105	COG1515	deoxyribonuclease V activity
HYQ63_RS34115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYQ63_RS34125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYQ63_RS34130	COG0183	Belongs to the thiolase family
HYQ63_RS34135	COG1024	Enoyl-CoA hydratase
HYQ63_RS34135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYQ63_RS34150	COG3250	beta-galactosidase activity
HYQ63_RS34165	COG2936	dipeptidyl-peptidase activity
HYQ63_RS34175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYQ63_RS34185	COG0488	(ABC) transporter
HYQ63_RS34190	COG2183	response to ionizing radiation
HYQ63_RS34205	COG1024	Enoyl-CoA hydratase
HYQ63_RS34215	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HYQ63_RS34260	COG1134	teichoic acid transport
HYQ63_RS34270	COG1562	ergosterol biosynthetic process
HYQ63_RS34280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HYQ63_RS34290	COG1657	PFAM Prenyltransferase squalene oxidase
HYQ63_RS34305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYQ63_RS34330	COG2755	lipolytic protein G-D-S-L family
HYQ63_RS34415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HYQ63_RS34420	COG0531	amino acid
HYQ63_RS34435	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS34460	COG1404	Belongs to the peptidase S8 family
HYQ63_RS34475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HYQ63_RS34485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HYQ63_RS34490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYQ63_RS34495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYQ63_RS34500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYQ63_RS34505	COG5002	protein histidine kinase activity
HYQ63_RS34510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYQ63_RS34515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYQ63_RS34515	COG0072	phenylalanine-tRNA ligase activity
HYQ63_RS34530	COG1051	belongs to the nudix hydrolase family
HYQ63_RS34540	COG1285	pathogenesis
HYQ63_RS34555	COG1649	PFAM Uncharacterised BCR, COG1649
HYQ63_RS34565	COG0697	spore germination
HYQ63_RS34570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYQ63_RS34585	COG4941	Belongs to the sigma-70 factor family
HYQ63_RS34600	COG2378	regulation of single-species biofilm formation
HYQ63_RS34605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HYQ63_RS34610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HYQ63_RS34615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HYQ63_RS34620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYQ63_RS34625	COG1438	arginine binding
HYQ63_RS34630	COG0385	Bile acid
HYQ63_RS34730	COG0137	argininosuccinate synthase activity
HYQ63_RS34735	COG0165	Argininosuccinate lyase
HYQ63_RS34750	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS34750	COG0204	Acyl-transferase
HYQ63_RS34785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYQ63_RS34790	COG2011	ABC-type metal ion transport system permease component
HYQ63_RS34795	COG1464	Belongs to the NlpA lipoprotein family
HYQ63_RS34810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HYQ63_RS34815	COG1648	precorrin-2 dehydrogenase activity
HYQ63_RS34815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HYQ63_RS34865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYQ63_RS34915	COG1653	transport
HYQ63_RS34920	COG1175	transmembrane transport
HYQ63_RS34925	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS34955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYQ63_RS34970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYQ63_RS34985	COG3415	Transposase
HYQ63_RS34985	COG2801	Transposase and inactivated derivatives
HYQ63_RS35000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYQ63_RS35005	COG1560	Kdo2-lipid A biosynthetic process
HYQ63_RS35010	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS35020	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HYQ63_RS35025	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HYQ63_RS35030	COG0217	transcriptional regulatory protein
HYQ63_RS35035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYQ63_RS35040	COG0632	four-way junction helicase activity
HYQ63_RS35045	COG2255	four-way junction helicase activity
HYQ63_RS35055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYQ63_RS35060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYQ63_RS35065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYQ63_RS35070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYQ63_RS35075	COG1196	nuclear chromosome segregation
HYQ63_RS35080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYQ63_RS35090	COG0124	histidyl-tRNA synthetase
HYQ63_RS35110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYQ63_RS35125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYQ63_RS35130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYQ63_RS35140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYQ63_RS35145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYQ63_RS35150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYQ63_RS35155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYQ63_RS35165	COG0006	proline dipeptidase activity
HYQ63_RS35170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYQ63_RS35175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYQ63_RS35185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HYQ63_RS35190	COG0540	Belongs to the ATCase OTCase family
HYQ63_RS35195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYQ63_RS35205	COG0505	Belongs to the CarA family
HYQ63_RS35210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYQ63_RS35215	COG0167	dihydroorotate dehydrogenase activity
HYQ63_RS35220	COG0284	orotidine-5'-phosphate decarboxylase activity
HYQ63_RS35245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYQ63_RS35260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYQ63_RS35275	COG2838	Isocitrate dehydrogenase
HYQ63_RS35285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYQ63_RS35290	COG2390	Transcriptional regulator
HYQ63_RS35310	COG0531	amino acid
HYQ63_RS35320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYQ63_RS35345	COG2233	PERMEase
HYQ63_RS35355	COG0738	Major facilitator superfamily
HYQ63_RS35375	COG3201	nicotinamide mononucleotide transporter
HYQ63_RS35380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYQ63_RS35380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYQ63_RS35385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HYQ63_RS35390	COG0140	phosphoribosyl-ATP diphosphatase activity
HYQ63_RS35395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HYQ63_RS35475	COG0589	response to stress
HYQ63_RS35480	COG0517	IMP dehydrogenase activity
HYQ63_RS35480	COG0516	GMP reductase activity
HYQ63_RS35495	COG0517	IMP dehydrogenase activity
HYQ63_RS35505	COG1937	Protein conserved in bacteria
HYQ63_RS35510	COG2217	Heavy metal translocating P-type atpase
HYQ63_RS35540	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HYQ63_RS35545	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HYQ63_RS35585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYQ63_RS35585	COG0045	succinate-CoA ligase (ADP-forming) activity
HYQ63_RS35585	COG1042	CoA-binding domain protein
HYQ63_RS35600	COG3383	formate dehydrogenase (NAD+) activity
HYQ63_RS35605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYQ63_RS35660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYQ63_RS35675	COG0798	PFAM Bile acid sodium symporter
HYQ63_RS35680	COG2072	flavoprotein involved in K transport
HYQ63_RS35710	COG0640	Transcriptional regulator
HYQ63_RS35715	COG2072	flavoprotein involved in K transport
HYQ63_RS35740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYQ63_RS35745	COG0569	domain protein
HYQ63_RS35750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYQ63_RS35770	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HYQ63_RS35785	COG1131	(ABC) transporter
HYQ63_RS36010	COG3693	PFAM glycoside hydrolase, family 10
HYQ63_RS36055	COG1131	(ABC) transporter
HYQ63_RS36070	COG2860	membrane
HYQ63_RS36090	COG2340	Cysteine-rich secretory protein family
HYQ63_RS36095	COG1113	amino acid transport
HYQ63_RS36110	COG1021	2,3-dihydroxybenzoate-AMP ligase
HYQ63_RS36150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYQ63_RS36165	COG1215	transferase activity, transferring glycosyl groups
HYQ63_RS36175	COG4310	Domain of unknown function (DUF2172)
HYQ63_RS36190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYQ63_RS36200	COG0438	transferase activity, transferring glycosyl groups
HYQ63_RS36225	COG0367	asparagine synthase
HYQ63_RS36245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HYQ63_RS36270	COG1755	Isoprenylcysteine carboxyl methyltransferase
HYQ63_RS36275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYQ63_RS36290	COG1309	transcriptional regulator
HYQ63_RS36340	COG4221	oxidoreductase activity
HYQ63_RS36340	COG0300	oxidoreductase activity
HYQ63_RS36340	COG3321	synthase
HYQ63_RS36340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS36355	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS36355	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS36355	COG3321	synthase
HYQ63_RS36355	COG0300	oxidoreductase activity
HYQ63_RS36355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYQ63_RS36360	COG2070	2-Nitropropane dioxygenase
HYQ63_RS36360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYQ63_RS36365	COG2124	cytochrome p450
HYQ63_RS36390	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS36395	COG0778	Nitroreductase
HYQ63_RS36400	COG2085	NADP oxidoreductase coenzyme F420-dependent
HYQ63_RS36410	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS36430	COG2409	Drug exporters of the RND superfamily
HYQ63_RS36470	COG2070	2-Nitropropane dioxygenase
HYQ63_RS36485	COG0583	DNA-binding transcription factor activity
HYQ63_RS36500	COG0583	DNA-binding transcription factor activity
HYQ63_RS36535	COG1309	transcriptional regulator
HYQ63_RS36540	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS36545	COG2801	Transposase and inactivated derivatives
HYQ63_RS36545	COG3415	Transposase
HYQ63_RS36565	COG0604	alcohol dehydrogenase
HYQ63_RS36570	COG1902	pentaerythritol trinitrate reductase activity
HYQ63_RS36600	COG2315	Protein conserved in bacteria
HYQ63_RS36605	COG2315	Protein conserved in bacteria
HYQ63_RS36630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYQ63_RS36635	COG0483	inositol monophosphate 1-phosphatase activity
HYQ63_RS36645	COG2197	response regulator
HYQ63_RS36660	COG2319	Wd-40 repeat
HYQ63_RS36660	COG4249	Peptidase C14 caspase catalytic subunit p20
HYQ63_RS36690	COG4977	sequence-specific DNA binding
HYQ63_RS36750	COG0667	Aldo Keto reductase
HYQ63_RS36795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYQ63_RS36815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYQ63_RS36820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYQ63_RS36830	COG1414	Transcriptional regulator
HYQ63_RS36845	COG1864	DNA RNA non-specific endonuclease
HYQ63_RS36845	COG3591	Belongs to the peptidase S1B family
HYQ63_RS36855	COG3250	beta-galactosidase activity
HYQ63_RS36860	COG1953	Uracil, thiamine, allantoin
HYQ63_RS36870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYQ63_RS36885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYQ63_RS36890	COG1914	H( )-stimulated, divalent metal cation uptake system
HYQ63_RS36910	COG1609	Transcriptional regulator
HYQ63_RS36920	COG1175	transmembrane transport
HYQ63_RS36925	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS36975	COG1309	transcriptional regulator
HYQ63_RS36980	COG4221	oxidoreductase activity
HYQ63_RS36995	COG2197	response regulator
HYQ63_RS37025	COG3320	Male sterility
HYQ63_RS37025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS37055	COG2828	Protein conserved in bacteria
HYQ63_RS37060	COG1301	dicarboxylic acid transport
HYQ63_RS37065	COG0640	Transcriptional regulator
HYQ63_RS37080	COG1280	lysine exporter protein (LysE YggA)
HYQ63_RS37090	COG2814	Major facilitator Superfamily
HYQ63_RS37095	COG2814	Major facilitator Superfamily
HYQ63_RS37120	COG0702	epimerase
HYQ63_RS37125	COG1957	nucleoside hydrolase
HYQ63_RS37150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYQ63_RS37200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYQ63_RS37205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYQ63_RS37250	COG2169	Transcriptional regulator
HYQ63_RS37285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYQ63_RS37290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYQ63_RS37330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYQ63_RS37335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYQ63_RS37345	COG2084	Dehydrogenase
HYQ63_RS37350	COG1733	regulation of RNA biosynthetic process
HYQ63_RS37355	COG0667	Aldo Keto reductase
HYQ63_RS37385	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HYQ63_RS37385	COG3291	Pkd domain containing protein
HYQ63_RS37395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS37400	COG0488	(ABC) transporter
HYQ63_RS37405	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS37410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYQ63_RS37415	COG0583	DNA-binding transcription factor activity
HYQ63_RS37425	COG1064	alcohol dehydrogenase
HYQ63_RS37430	COG2272	Belongs to the type-B carboxylesterase lipase family
HYQ63_RS37450	COG2226	methyltransferase
HYQ63_RS37470	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS37500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYQ63_RS37520	COG0006	proline dipeptidase activity
HYQ63_RS37525	COG2188	Transcriptional regulator
HYQ63_RS37530	COG1397	ADP-ribosylglycohydrolase
HYQ63_RS37540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYQ63_RS37570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYQ63_RS37570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYQ63_RS37580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYQ63_RS37600	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HYQ63_RS37605	COG3251	PFAM MbtH domain protein
HYQ63_RS37610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYQ63_RS37645	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYQ63_RS37655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYQ63_RS37680	COG0477	Major facilitator Superfamily
HYQ63_RS37690	COG2197	response regulator
HYQ63_RS37695	COG4585	Histidine kinase
HYQ63_RS37730	COG3284	Transcriptional regulator
HYQ63_RS37735	COG1129	ABC transporter
HYQ63_RS37740	COG4214	carbohydrate transport
HYQ63_RS37750	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS37760	COG0477	Major facilitator Superfamily
HYQ63_RS37770	COG3959	Transketolase, thiamine diphosphate binding domain
HYQ63_RS37775	COG3958	Transketolase
HYQ63_RS37800	COG0601	transmembrane transport
HYQ63_RS37835	COG0477	Major facilitator Superfamily
HYQ63_RS37850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HYQ63_RS37870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS37875	COG4166	transmembrane transport
HYQ63_RS37885	COG3973	AAA domain
HYQ63_RS37890	COG2207	Transcriptional regulator
HYQ63_RS37895	COG2223	nitrite transmembrane transporter activity
HYQ63_RS37900	COG3655	Transcriptional regulator
HYQ63_RS37920	COG2072	flavoprotein involved in K transport
HYQ63_RS37930	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS37960	COG4249	Peptidase C14 caspase catalytic subunit p20
HYQ63_RS37960	COG2319	Wd-40 repeat
HYQ63_RS37985	COG3509	depolymerase
HYQ63_RS38000	COG0456	acetyltransferase
HYQ63_RS38000	COG0454	-acetyltransferase
HYQ63_RS38005	COG3321	synthase
HYQ63_RS38005	COG0604	alcohol dehydrogenase
HYQ63_RS38020	COG2267	carboxylic ester hydrolase activity
HYQ63_RS38035	COG0477	Major facilitator Superfamily
HYQ63_RS38045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYQ63_RS38060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYQ63_RS38115	COG2022	thiamine diphosphate biosynthetic process
HYQ63_RS38115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYQ63_RS38120	COG0604	alcohol dehydrogenase
HYQ63_RS38120	COG3321	synthase
HYQ63_RS38140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYQ63_RS38145	COG2814	Major facilitator Superfamily
HYQ63_RS38150	COG1609	Transcriptional regulator
HYQ63_RS38165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYQ63_RS38195	COG2814	Major facilitator Superfamily
HYQ63_RS38215	COG1070	Carbohydrate kinase
HYQ63_RS38220	COG2376	Dihydroxyacetone kinase
HYQ63_RS38225	COG0698	ribose 5-phosphate isomerase
HYQ63_RS38230	COG0154	amidase activity
HYQ63_RS38235	COG2391	methyltransferase activity
HYQ63_RS38290	COG2207	Transcriptional regulator
HYQ63_RS38290	COG3708	Transcriptional regulator
HYQ63_RS38295	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYQ63_RS38315	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS38330	COG3507	Belongs to the glycosyl hydrolase 43 family
HYQ63_RS38340	COG0667	Aldo Keto reductase
HYQ63_RS38370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYQ63_RS38375	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS38395	COG1309	transcriptional regulator
HYQ63_RS38400	COG0667	Aldo Keto reductase
HYQ63_RS38410	COG3321	synthase
HYQ63_RS38410	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS38410	COG0604	alcohol dehydrogenase
HYQ63_RS38430	COG0477	Major facilitator Superfamily
HYQ63_RS38445	COG2018	Roadblock/LC7 domain
HYQ63_RS38470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYQ63_RS38475	COG1609	Transcriptional regulator
HYQ63_RS38485	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS38490	COG1653	transport
HYQ63_RS38505	COG5297	Belongs to the glycosyl hydrolase family 6
HYQ63_RS38505	COG3250	beta-galactosidase activity
HYQ63_RS38520	COG2353	YceI-like domain
HYQ63_RS38525	COG3835	regulator
HYQ63_RS38560	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS38600	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HYQ63_RS38605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYQ63_RS38630	COG4221	oxidoreductase activity
HYQ63_RS38635	COG0583	DNA-binding transcription factor activity
HYQ63_RS38645	COG3485	protocatechuate 3,4-dioxygenase
HYQ63_RS38650	COG4829	muconolactone delta-isomerase
HYQ63_RS38680	COG1414	Transcriptional regulator
HYQ63_RS38685	COG0477	Major facilitator Superfamily
HYQ63_RS38700	COG4638	Rieske (2fe-2S)
HYQ63_RS38710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYQ63_RS38715	COG0154	amidase activity
HYQ63_RS38725	COG4977	sequence-specific DNA binding
HYQ63_RS38725	COG1917	Cupin 2, conserved barrel domain protein
HYQ63_RS38730	COG3903	Transcriptional regulator
HYQ63_RS38730	COG3629	intracellular signal transduction
HYQ63_RS38735	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYQ63_RS38740	COG1335	isochorismatase
HYQ63_RS38745	COG3619	membrane
HYQ63_RS38760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYQ63_RS38770	COG1819	glycosyl
HYQ63_RS38790	COG0277	FAD linked oxidase domain protein
HYQ63_RS38815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYQ63_RS38855	COG0701	Predicted permease
HYQ63_RS38860	COG3290	protein histidine kinase activity
HYQ63_RS38875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYQ63_RS38885	COG4221	oxidoreductase activity
HYQ63_RS38895	COG3046	protein related to deoxyribodipyrimidine photolyase
HYQ63_RS38905	COG0028	Belongs to the TPP enzyme family
HYQ63_RS38910	COG0477	Major facilitator Superfamily
HYQ63_RS38950	COG1609	Transcriptional regulator
HYQ63_RS38960	COG1175	transmembrane transport
HYQ63_RS38970	COG1609	Transcriptional regulator
HYQ63_RS38975	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS38980	COG1175	transmembrane transport
HYQ63_RS39030	COG2801	Transposase and inactivated derivatives
HYQ63_RS39030	COG3415	Transposase
HYQ63_RS39045	COG0444	Belongs to the ABC transporter superfamily
HYQ63_RS39055	COG0747	negative chemotaxis
HYQ63_RS39065	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS39085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYQ63_RS39090	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HYQ63_RS39095	COG3971	2-oxopent-4-enoate hydratase activity
HYQ63_RS39105	COG0492	ferredoxin-NADP+ reductase activity
HYQ63_RS39115	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HYQ63_RS39160	COG1063	alcohol dehydrogenase
HYQ63_RS39195	COG3387	PFAM Glycoside hydrolase 15-related
HYQ63_RS39200	COG0577	efflux transmembrane transporter activity
HYQ63_RS39205	COG4585	Histidine kinase
HYQ63_RS39210	COG2197	response regulator
HYQ63_RS39220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HYQ63_RS39225	COG4988	ABC transporter
HYQ63_RS39240	COG1271	oxidase subunit
HYQ63_RS39245	COG0477	Major facilitator Superfamily
HYQ63_RS39255	COG0129	dihydroxy-acid dehydratase activity
HYQ63_RS39260	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HYQ63_RS39270	COG0531	amino acid
HYQ63_RS39285	COG1609	Transcriptional regulator
HYQ63_RS39300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYQ63_RS39330	COG4585	Histidine kinase
HYQ63_RS39335	COG2197	response regulator
HYQ63_RS39360	COG4214	carbohydrate transport
HYQ63_RS39370	COG4213	ABC transporter substrate-binding protein
HYQ63_RS39420	COG3209	COG3209 Rhs family protein
HYQ63_RS39460	COG2340	Cysteine-rich secretory protein family
HYQ63_RS39510	COG4585	Histidine kinase
HYQ63_RS39515	COG2197	response regulator
HYQ63_RS39525	COG1175	transmembrane transport
HYQ63_RS39535	COG0326	Molecular chaperone. Has ATPase activity
HYQ63_RS39555	COG0531	amino acid
HYQ63_RS39575	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS39585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYQ63_RS39590	COG1414	Transcriptional regulator
HYQ63_RS39615	COG2610	gluconate transmembrane transporter activity
HYQ63_RS39650	COG1228	amidohydrolase
HYQ63_RS39655	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HYQ63_RS39660	COG1968	undecaprenyl-diphosphatase activity
HYQ63_RS39670	COG0679	Auxin Efflux Carrier
HYQ63_RS39675	COG0281	malic enzyme
HYQ63_RS39685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HYQ63_RS39730	COG1309	transcriptional regulator
HYQ63_RS39770	COG1064	alcohol dehydrogenase
HYQ63_RS39775	COG0477	Major facilitator Superfamily
HYQ63_RS39780	COG0246	Mannitol dehydrogenase
HYQ63_RS39785	COG4948	Mandelate Racemase Muconate Lactonizing
HYQ63_RS39790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYQ63_RS39795	COG1609	Transcriptional regulator
HYQ63_RS39800	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HYQ63_RS39830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYQ63_RS39840	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYQ63_RS39850	COG3938	Belongs to the proline racemase family
HYQ63_RS39855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HYQ63_RS39865	COG1070	Carbohydrate kinase
HYQ63_RS39875	COG1609	Transcriptional regulator
HYQ63_RS39890	COG0668	transmembrane transport
HYQ63_RS39900	COG0366	Alpha amylase catalytic
HYQ63_RS39910	COG1609	Transcriptional regulator
HYQ63_RS39935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYQ63_RS39940	COG0739	heme binding
HYQ63_RS39955	COG2508	Transcriptional regulator
HYQ63_RS39965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYQ63_RS39980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYQ63_RS40005	COG0596	Alpha beta hydrolase
HYQ63_RS40010	COG0326	Molecular chaperone. Has ATPase activity
HYQ63_RS40025	COG0248	Ppx GppA phosphatase
HYQ63_RS40035	COG0697	spore germination
HYQ63_RS40060	COG1120	ATPase activity
HYQ63_RS40065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYQ63_RS40095	COG3250	beta-galactosidase activity
HYQ63_RS40135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYQ63_RS40140	COG2080	2 iron, 2 sulfur cluster binding
HYQ63_RS40145	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYQ63_RS40150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYQ63_RS40170	COG3594	Acyltransferase
HYQ63_RS40175	COG2376	Dihydroxyacetone kinase
HYQ63_RS40180	COG2376	Dihydroxyacetone kinase
HYQ63_RS40185	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYQ63_RS40195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYQ63_RS40205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYQ63_RS40210	COG2271	Major facilitator Superfamily
HYQ63_RS40235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HYQ63_RS40240	COG0596	Alpha beta hydrolase
HYQ63_RS40250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYQ63_RS40255	COG0300	oxidoreductase activity
HYQ63_RS40265	COG0726	polysaccharide deacetylase
HYQ63_RS40275	COG2267	carboxylic ester hydrolase activity
HYQ63_RS40290	COG3903	Transcriptional regulator
HYQ63_RS40290	COG3629	intracellular signal transduction
HYQ63_RS40295	COG2175	clavaminate synthase activity
HYQ63_RS40305	COG0583	DNA-binding transcription factor activity
HYQ63_RS40320	COG2197	response regulator
HYQ63_RS40330	COG0577	efflux transmembrane transporter activity
HYQ63_RS40330	COG1136	(ABC) transporter
HYQ63_RS40340	COG0306	phosphate transporter
HYQ63_RS40350	COG1357	PFAM Pentapeptide repeats (8 copies)
HYQ63_RS40370	COG1486	melibiose metabolic process
HYQ63_RS40385	COG1175	transmembrane transport
HYQ63_RS40390	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS40395	COG3250	beta-galactosidase activity
HYQ63_RS40400	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS40415	COG1609	Transcriptional regulator
HYQ63_RS40425	COG2211	Major facilitator Superfamily
HYQ63_RS40455	COG0583	DNA-binding transcription factor activity
HYQ63_RS40465	COG1414	Transcriptional regulator
HYQ63_RS40470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYQ63_RS40475	COG3608	succinylglutamate desuccinylase aspartoacylase
HYQ63_RS40485	COG3842	ATPase activity
HYQ63_RS40500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYQ63_RS40510	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS40515	COG0667	Aldo Keto reductase
HYQ63_RS40525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYQ63_RS40535	COG1653	transport
HYQ63_RS40580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYQ63_RS40610	COG3511	phospholipase C
HYQ63_RS40690	COG1522	sequence-specific DNA binding
HYQ63_RS40690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYQ63_RS40695	COG2313	pseudouridylate synthase activity
HYQ63_RS40765	COG1252	NADH dehydrogenase
HYQ63_RS40770	COG1595	DNA-templated transcription, initiation
HYQ63_RS40795	COG0542	response to heat
HYQ63_RS40805	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYQ63_RS40810	COG2936	dipeptidyl-peptidase activity
HYQ63_RS40920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYQ63_RS40935	COG2271	Major facilitator Superfamily
HYQ63_RS40945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYQ63_RS41005	COG1215	transferase activity, transferring glycosyl groups
HYQ63_RS41030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYQ63_RS41035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYQ63_RS41040	COG2080	2 iron, 2 sulfur cluster binding
HYQ63_RS41055	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HYQ63_RS41110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYQ63_RS41115	COG0477	Major facilitator Superfamily
HYQ63_RS41120	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HYQ63_RS41135	COG0300	oxidoreductase activity
HYQ63_RS41140	COG0436	Aminotransferase
HYQ63_RS41150	COG0069	glutamate synthase activity
HYQ63_RS41160	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS41210	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS41215	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS41220	COG0673	inositol 2-dehydrogenase activity
HYQ63_RS41230	COG2319	Wd-40 repeat
HYQ63_RS41230	COG4249	Peptidase C14 caspase catalytic subunit p20
HYQ63_RS41255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYQ63_RS41265	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS41270	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS41295	COG0747	negative chemotaxis
HYQ63_RS41305	COG0154	amidase activity
HYQ63_RS41315	COG1522	sequence-specific DNA binding
HYQ63_RS41330	COG2259	Doxx family
HYQ63_RS41335	COG0477	Major facilitator Superfamily
HYQ63_RS41360	COG3012	SEC-C Motif Domain Protein
HYQ63_RS41365	COG1063	alcohol dehydrogenase
HYQ63_RS41370	COG2271	Major facilitator Superfamily
HYQ63_RS41375	COG0246	Mannitol dehydrogenase
HYQ63_RS41400	COG0437	4 iron, 4 sulfur cluster binding
HYQ63_RS41405	COG3383	formate dehydrogenase (NAD+) activity
HYQ63_RS41405	COG0243	molybdopterin cofactor binding
HYQ63_RS41420	COG0596	Alpha beta hydrolase
HYQ63_RS41440	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HYQ63_RS41515	COG2340	Cysteine-rich secretory protein family
HYQ63_RS41530	COG0531	amino acid
HYQ63_RS41550	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYQ63_RS41550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYQ63_RS41570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYQ63_RS41590	COG0656	L-ascorbic acid biosynthetic process
HYQ63_RS41605	COG1129	ABC transporter
HYQ63_RS41645	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS41715	COG0318	PFAM AMP-dependent synthetase and ligase
HYQ63_RS41720	COG1937	Protein conserved in bacteria
HYQ63_RS41740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYQ63_RS41755	COG2124	cytochrome p450
HYQ63_RS41790	COG4608	Belongs to the ABC transporter superfamily
HYQ63_RS41800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYQ63_RS41805	COG0747	negative chemotaxis
HYQ63_RS41810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYQ63_RS41815	COG0254	rRNA binding
HYQ63_RS41825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYQ63_RS41830	COG0701	Predicted permease
HYQ63_RS41860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYQ63_RS41870	COG0019	diaminopimelate decarboxylase activity
HYQ63_RS41935	COG1609	Transcriptional regulator
HYQ63_RS41940	COG2271	Major facilitator Superfamily
HYQ63_RS41945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYQ63_RS41980	COG3629	intracellular signal transduction
HYQ63_RS41980	COG3903	Transcriptional regulator
HYQ63_RS42005	COG1012	belongs to the aldehyde dehydrogenase family
HYQ63_RS42020	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HYQ63_RS42035	COG1902	pentaerythritol trinitrate reductase activity
HYQ63_RS42035	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYQ63_RS42040	COG2130	NADP-dependent
HYQ63_RS42100	COG1024	Enoyl-CoA hydratase
HYQ63_RS42125	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HYQ63_RS42130	COG0121	glutamine amidotransferase
HYQ63_RS42135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYQ63_RS42150	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS42155	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS42165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYQ63_RS42170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYQ63_RS42190	COG1940	carbohydrate kinase activity
HYQ63_RS42210	COG4279	zinc finger
HYQ63_RS42215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYQ63_RS42260	COG2018	Roadblock/LC7 domain
HYQ63_RS42270	COG1946	Acyl-CoA thioesterase
HYQ63_RS42285	COG1132	(ABC) transporter
HYQ63_RS42290	COG1132	(ABC) transporter
HYQ63_RS42310	COG1132	(ABC) transporter
HYQ63_RS42320	COG3458	cephalosporin-C deacetylase activity
HYQ63_RS42335	COG1126	abc transporter atp-binding protein
HYQ63_RS42340	COG0765	amino acid transport
HYQ63_RS42370	COG3940	Belongs to the glycosyl hydrolase 43 family
HYQ63_RS42385	COG0667	Aldo Keto reductase
HYQ63_RS42450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYQ63_RS42455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYQ63_RS42460	COG2080	2 iron, 2 sulfur cluster binding
HYQ63_RS42470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYQ63_RS42485	COG1063	alcohol dehydrogenase
HYQ63_RS42490	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYQ63_RS42495	COG1129	ABC transporter
HYQ63_RS42500	COG1879	ABC-type sugar transport system periplasmic component
HYQ63_RS42510	COG3250	beta-galactosidase activity
HYQ63_RS42520	COG3250	beta-galactosidase activity
HYQ63_RS42525	COG0395	ABC-type sugar transport system, permease component
HYQ63_RS42530	COG1653	transport
HYQ63_RS42540	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS42545	COG1802	Transcriptional regulator
HYQ63_RS42560	COG3386	PFAM SMP-30 Gluconolaconase
HYQ63_RS42570	COG3485	protocatechuate 3,4-dioxygenase
HYQ63_RS42580	COG2409	Drug exporters of the RND superfamily
HYQ63_RS42585	COG4585	Histidine kinase
HYQ63_RS42590	COG2197	response regulator
HYQ63_RS42610	COG0640	Transcriptional regulator
HYQ63_RS42615	COG0523	cobalamin synthesis protein
HYQ63_RS42625	COG2124	cytochrome p450
HYQ63_RS42635	COG0148	phosphopyruvate hydratase activity
HYQ63_RS42645	COG3940	Belongs to the glycosyl hydrolase 43 family
HYQ63_RS42650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYQ63_RS42655	COG0583	DNA-binding transcription factor activity
HYQ63_RS42670	COG0604	alcohol dehydrogenase
HYQ63_RS42705	COG1309	transcriptional regulator
HYQ63_RS42715	COG1063	alcohol dehydrogenase
HYQ63_RS42745	COG0667	Aldo Keto reductase
HYQ63_RS42750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYQ63_RS42790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYQ63_RS42790	COG1796	DNA polymerase
HYQ63_RS42795	COG2353	YceI-like domain
HYQ63_RS42800	COG1082	Xylose isomerase domain protein TIM barrel
HYQ63_RS42820	COG2197	response regulator
HYQ63_RS42825	COG4585	Histidine kinase
HYQ63_RS42835	COG2345	Transcriptional regulator
HYQ63_RS42840	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYQ63_RS42845	COG1017	nitric oxide dioxygenase activity
HYQ63_RS42845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYQ63_RS42850	COG1959	2 iron, 2 sulfur cluster binding
HYQ63_RS42885	COG0435	Glutathione S-transferase
HYQ63_RS42890	COG3976	FMN-binding domain protein
HYQ63_RS42890	COG1053	succinate dehydrogenase
HYQ63_RS42895	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS42915	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS42920	COG1024	Enoyl-CoA hydratase
HYQ63_RS42930	COG0183	Belongs to the thiolase family
HYQ63_RS42935	COG1960	acyl-CoA dehydrogenase activity
HYQ63_RS42950	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS42955	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS42960	COG1024	Enoyl-CoA hydratase
HYQ63_RS42990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYQ63_RS42995	COG2815	serine threonine protein kinase
HYQ63_RS42995	COG0515	serine threonine protein kinase
HYQ63_RS43000	COG3693	PFAM glycoside hydrolase, family 10
HYQ63_RS43010	COG3629	intracellular signal transduction
HYQ63_RS43010	COG3903	Transcriptional regulator
HYQ63_RS43115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYQ63_RS43185	COG0583	DNA-binding transcription factor activity
HYQ63_RS43200	COG1132	(ABC) transporter
HYQ63_RS43205	COG1132	(ABC) transporter
HYQ63_RS43210	COG0302	gtp cyclohydrolase
HYQ63_RS43220	COG0720	synthase
HYQ63_RS43245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYQ63_RS43275	COG0601	transmembrane transport
HYQ63_RS43330	COG2197	response regulator
HYQ63_RS43355	COG0328	RNA-DNA hybrid ribonuclease activity
HYQ63_RS43400	COG1404	Belongs to the peptidase S8 family
HYQ63_RS43405	COG1674	ftsk spoiiie
HYQ63_RS43490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HYQ63_RS43500	COG1073	alpha beta
HYQ63_RS43510	COG1028	Short-chain dehydrogenase reductase Sdr
HYQ63_RS43550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYQ63_RS43605	COG1819	glycosyl
HYQ63_RS43720	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HYQ63_RS43725	COG3293	Transposase
HYQ63_RS43780	COG1522	sequence-specific DNA binding
HYQ63_RS43795	COG2801	Transposase and inactivated derivatives
HYQ63_RS43795	COG3415	Transposase
HYQ63_RS43820	COG2801	Transposase and inactivated derivatives
HYQ63_RS43825	COG2801	Transposase and inactivated derivatives