locus-tag class description HEP87_RS00195 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEP87_RS00195 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEP87_RS00240 ENOG4105ECP epimerase HEP87_RS00295 ENOG4105D5G Transposase HEP87_RS00300 ENOG4108W5M transcriptional regulator HEP87_RS00330 ENOG4105VNT transposase (IS4 family) protein HEP87_RS00380 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HEP87_RS00390 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS00415 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP87_RS00480 ENOG4105I1F Resistance protein HEP87_RS00505 ENOG4105RKW reductase (By HEP87_RS00530 ENOG4105EV9 Alpha Beta Hydrolase HEP87_RS00540 ENOG4105EJ2 Transcriptional regulator HEP87_RS00545 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP87_RS00640 ENOG4107R6F Alpha Beta Hydrolase Fold protein HEP87_RS00650 ENOG4105WN5 stage II sporulation protein HEP87_RS00670 ENOG4105BZU Histidine kinase HEP87_RS00675 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS00755 ENOG4105EW9 transcriptional regulator AsnC family HEP87_RS00775 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HEP87_RS00785 ENOG4105N14 lysine exporter protein LysE YggA HEP87_RS00790 ENOG4105D74 hydrolase HEP87_RS00810 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEP87_RS00830 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP87_RS00850 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP87_RS00860 ENOG4108JSS Haloalkane dehalogenase HEP87_RS00875 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP87_RS00885 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HEP87_RS00930 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEP87_RS01185 ENOG4105EW9 transcriptional regulator AsnC family HEP87_RS01190 ENOG4108UMN azlc family HEP87_RS01195 ENOG4105KMT branched-chain amino acid HEP87_RS01230 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP87_RS01350 ENOG4105MP0 transposase HEP87_RS01365 ENOG4107QRP cobalamin biosynthesis protein CobW HEP87_RS01370 ENOG4108WYP Transcriptional regulator HEP87_RS01415 ENOG4106F60 Histidine kinase HEP87_RS01420 ENOG4105ETX regulatoR HEP87_RS01430 ENOG4107R13 MMPL domain protein HEP87_RS01440 ENOG4107RCV ABC transporter, permease HEP87_RS01445 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP87_RS01515 ENOG4105KF0 sporulation and cell division protein, SsgA HEP87_RS01560 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEP87_RS01635 ENOG4105KVH Transcriptional regulator HEP87_RS01710 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HEP87_RS01725 ENOG4105K59 histidine triad (HIT) protein HEP87_RS01730 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HEP87_RS01745 ENOG4108FPN Integrase HEP87_RS01790 ENOG4105D5G Transposase HEP87_RS01825 ENOG4107SVN transposase HEP87_RS01915 ENOG4107SWG transcriptional regulator MERR family HEP87_RS01940 ENOG4105IDI abc transporter atp-binding protein HEP87_RS02105 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEP87_RS02110 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP87_RS02115 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HEP87_RS02170 ENOG4105D7V transposase HEP87_RS02175 ENOG4107S5I aldo keto reductase HEP87_RS02190 ENOG4105E0A ABC, transporter HEP87_RS02195 ENOG4105EHG Permease protein HEP87_RS02210 ENOG4105WQI isochorismatase HEP87_RS02230 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP87_RS02310 ENOG4105JAB phenazine biosynthesis protein, phzf family HEP87_RS02335 ENOG4105DWV Homoserine O-trans-acetylase HEP87_RS02355 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HEP87_RS02365 ENOG4105CUV Homoserine Kinase HEP87_RS02395 ENOG4107Y9U Membrane HEP87_RS02425 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP87_RS02490 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HEP87_RS02525 ENOG4105CS1 NAD(P)H quinone oxidoreductase HEP87_RS02540 ENOG41082JN Transcriptional regulator HEP87_RS02545 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP87_RS02565 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS02575 ENOG4105E39 Enoyl-CoA hydratase HEP87_RS02580 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS02590 ENOG4107SET aldo keto reductase HEP87_RS02595 ENOG4105CY0 Metallo-Beta-Lactamase HEP87_RS02655 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP87_RS02670 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HEP87_RS02685 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HEP87_RS02710 ENOG4105CHR reductase HEP87_RS02775 ENOG4105KF0 sporulation and cell division protein, SsgA HEP87_RS02790 ENOG4106NZI LysR family Transcriptional regulator HEP87_RS02800 ENOG4108Q9V regulatoR HEP87_RS02815 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HEP87_RS02840 ENOG4105C26 Dehydrogenase HEP87_RS02860 ENOG4108Z6Z Transcriptional regulator HEP87_RS02895 ENOG4105ENX hydrolase HEP87_RS02905 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP87_RS02910 ENOG4107S5I aldo keto reductase HEP87_RS02925 ENOG4107VFM Dehydrogenase HEP87_RS02950 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS03000 ENOG4107QN1 sodium solute HEP87_RS03010 ENOG4105C4M (Ubiquinol oxidase) subunit I HEP87_RS03045 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS03070 ENOG4105E2X shikimate dehydrogenase HEP87_RS03090 ENOG4107S5I aldo keto reductase HEP87_RS03095 ENOG4105C2C drug resistance transporter, Bcr CflA HEP87_RS03155 ENOG4105VF7 tolerance protein HEP87_RS03185 ENOG4105BZP glycoside hydrolase 15-related HEP87_RS03210 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HEP87_RS03355 ENOG4108X7A Terpene synthase metal-binding domain-containing protein HEP87_RS03365 ENOG4105EKQ RNA-directed DNA polymerase HEP87_RS03480 ENOG4107SVN transposase HEP87_RS03490 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS03495 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HEP87_RS03500 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP87_RS03510 ENOG4105CB2 alcohol dehydrogenase HEP87_RS03515 ENOG4105E1F short-chain dehydrogenase reductase HEP87_RS03550 ENOG4105VMP Transcriptional regulator HEP87_RS03605 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HEP87_RS03620 ENOG4105D7V transposase HEP87_RS03630 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HEP87_RS03645 ENOG4105E1F short-chain dehydrogenase reductase HEP87_RS03650 ENOG4108R85 Short chain dehydrogenase HEP87_RS03655 ENOG4105FDP GntR family transcriptional regulator HEP87_RS03680 ENOG4107QWR cellulase (EC 3.2.1.4) HEP87_RS03735 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS03750 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP87_RS03755 ENOG4105F0H myo-inositol catabolism protein HEP87_RS03765 ENOG4105ESN nucleotide-binding protein HEP87_RS03775 ENOG4108PA7 Methyltransferase HEP87_RS03805 ENOG4106UDK Cellulose-binding, family II HEP87_RS03845 ENOG4107STQ Multicopper oxidase HEP87_RS03855 ENOG4105DUM transcriptional regulator, lysR family HEP87_RS03860 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HEP87_RS03865 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP87_RS03870 ENOG4105CHR reductase HEP87_RS03875 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP87_RS03920 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS04045 ENOG4105ETS cytosine purines uracil thiamine allantoin HEP87_RS04065 ENOG4105E2A Dehydrogenase HEP87_RS04075 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS04100 ENOG4105F0H myo-inositol catabolism protein HEP87_RS04110 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HEP87_RS04140 ENOG4105JQZ Methyltransferase HEP87_RS04170 ENOG4105DFW ABC transporter HEP87_RS04180 ENOG4105DFW ABC transporter HEP87_RS04185 ENOG4105C2J ABC transporter HEP87_RS04200 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP87_RS04205 ENOG4108K8U Glycerol operon regulatory protein HEP87_RS04230 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS04240 ENOG4107YCR Transcriptional regulator, ARSR family HEP87_RS04260 ENOG4107SET aldo keto reductase HEP87_RS04265 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEP87_RS04270 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS04330 ENOG4105EHG Permease protein HEP87_RS04335 ENOG4105E0A ABC, transporter HEP87_RS04405 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP87_RS04410 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HEP87_RS04490 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS04495 ENOG410800I Aminomethyltransferase HEP87_RS04500 ENOG4105C4K Nad synthetase HEP87_RS04505 ENOG4105DAE Methylenetetrahydrofolate reductase HEP87_RS04515 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HEP87_RS04525 ENOG4105DQ4 alcohol dehydrogenase HEP87_RS04530 ENOG4105E2A Dehydrogenase HEP87_RS04545 ENOG4107RTD sua5 ycio yrdc ywlc family protein HEP87_RS04560 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HEP87_RS04590 ENOG4107HP6 Transcriptional regulator HEP87_RS04595 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HEP87_RS04600 ENOG4105C6Z Gluconate HEP87_RS04605 ENOG4105EQX glucarate dehydratase HEP87_RS04620 ENOG4105C19 ABC transporter HEP87_RS04625 ENOG4105BZU Histidine kinase HEP87_RS04630 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS04635 ENOG4105J7D transcriptional regulator HEP87_RS04640 ENOG4105CHR reductase HEP87_RS04665 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEP87_RS04675 ENOG4105D5U fad dependent oxidoreductase HEP87_RS04680 ENOG4105C26 Dehydrogenase HEP87_RS04725 ENOG4105CR8 Transcriptional regulator HEP87_RS04730 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEP87_RS04735 ENOG4105CNN ABC, transporter HEP87_RS04740 ENOG4105C2J ABC transporter HEP87_RS04770 ENOG4105JSC dimethylmenaquinone methyltransferase HEP87_RS04780 ENOG4108QBF Transcriptional regulator HEP87_RS04790 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS04795 ENOG4105EQ2 LysR family Transcriptional regulator HEP87_RS04815 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP87_RS04970 ENOG4105E2R ROK family HEP87_RS05020 ENOG4108V1U phospholipid-binding protein HEP87_RS05035 ENOG4105CHR reductase HEP87_RS05040 ENOG4107YCY Transcriptional regulator HEP87_RS05045 ENOG4105E39 Enoyl-CoA hydratase HEP87_RS05050 ENOG4105D2B acyl-CoA dehydrogenase HEP87_RS05055 ENOG4105CC9 acyl-Coa dehydrogenase HEP87_RS05060 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS05070 ENOG4105CGU Enoyl-CoA hydratase HEP87_RS05075 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS05080 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS05085 ENOG4105CHR reductase HEP87_RS05125 ENOG4108IV0 ABC, transporter HEP87_RS05130 ENOG4105C0Z ABC transporter HEP87_RS05150 ENOG4105CC9 acyl-Coa dehydrogenase HEP87_RS05165 ENOG4105EBR Carboxylesterase HEP87_RS05170 ENOG4105E39 Enoyl-CoA hydratase HEP87_RS05190 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS05200 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HEP87_RS05210 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP87_RS05225 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS05235 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS05245 ENOG4105E39 Enoyl-CoA hydratase HEP87_RS05255 ENOG4108RZE Tetr family transcriptional regulator HEP87_RS05295 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP87_RS05300 ENOG4105C26 Dehydrogenase HEP87_RS05315 ENOG4105CHR reductase HEP87_RS05325 ENOG4105DVW rieske (2Fe-2S) HEP87_RS05345 ENOG4105CC9 acyl-Coa dehydrogenase HEP87_RS05370 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS05405 ENOG4108RZE Tetr family transcriptional regulator HEP87_RS05425 ENOG4105EQ0 Major Facilitator superfamily HEP87_RS05475 ENOG4105DNP FAD linked oxidase domain protein HEP87_RS05490 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HEP87_RS05500 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HEP87_RS05545 ENOG4108YIQ Alpha beta hydrolase HEP87_RS05585 ENOG4105E8G Major facilitator Superfamily HEP87_RS05610 ENOG4107VIJ nudix hydrolase HEP87_RS05620 ENOG4108RZ2 Glycoside hydrolase family 16 HEP87_RS05625 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS05635 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS05640 ENOG4105EGE secreted protein HEP87_RS05655 ENOG4105EX0 alpha-galactosidase HEP87_RS05665 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP87_RS05675 ENOG4105E2R ROK family HEP87_RS05695 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HEP87_RS05700 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HEP87_RS05710 ENOG4105EJQ L-serine dehydratase HEP87_RS05715 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP87_RS05720 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HEP87_RS05765 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HEP87_RS05780 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component HEP87_RS05785 ENOG4108IJ7 Glycine betaine HEP87_RS05820 ENOG4105DVW rieske (2Fe-2S) HEP87_RS05835 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HEP87_RS05880 ENOG4107RN3 metallophosphoesterase HEP87_RS06000 ENOG4108J5G 6-phosphogluconate dehydrogenase HEP87_RS06045 ENOG4108YYH Nadph-dependent fmn reductase HEP87_RS06165 ENOG4105DYW oxidoreductase HEP87_RS06195 ENOG4105CIR epoxide hydrolase HEP87_RS06200 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP87_RS06205 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP87_RS06235 ENOG4105BZU Histidine kinase HEP87_RS06300 ENOG4105IDI abc transporter atp-binding protein HEP87_RS06330 ENOG4108M0I Transcriptional regulator HEP87_RS06345 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP87_RS06350 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HEP87_RS06360 ENOG410841Q phosphoesterase PA-phosphatase related protein HEP87_RS06375 ENOG4107S5I aldo keto reductase HEP87_RS06385 ENOG4105C26 Dehydrogenase HEP87_RS06405 ENOG4105C32 Amino acid ABC transporter (Permease) HEP87_RS06420 ENOG4108IV0 ABC, transporter HEP87_RS06440 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HEP87_RS06480 ENOG4105CVP deoxyribo-dipyrimidine photolyase HEP87_RS06655 ENOG4105C5X domain protein HEP87_RS06675 ENOG4105CPC Aldo Keto reductase HEP87_RS06705 ENOG4105CAQ asparagine synthetase HEP87_RS06710 ENOG4105CBC glutamate synthase HEP87_RS06715 ENOG4105CEU Arginine dihydrolase HEP87_RS06720 ENOG4105D5Q Arginine ornithine antiporter HEP87_RS06730 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP87_RS06845 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS06970 ENOG4107T6F Xaa-Pro aminopeptidase HEP87_RS06975 ENOG4107MM9 BNR Asp-box repeat-containing protein HEP87_RS06995 ENOG4105X7H acyl-CoA dehydrogenase HEP87_RS07025 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS07030 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP87_RS07045 ENOG4105C26 Dehydrogenase HEP87_RS07050 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEP87_RS07055 ENOG4105DH8 myo-inositol catabolism HEP87_RS07065 ENOG4105EDK PfkB domain protein HEP87_RS07075 ENOG4105CNN ABC, transporter HEP87_RS07080 ENOG4105C2J ABC transporter HEP87_RS07100 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HEP87_RS07105 ENOG4107R5W Monooxygenase HEP87_RS07110 ENOG4105DVW rieske (2Fe-2S) HEP87_RS07125 ENOG4105D2B acyl-CoA dehydrogenase HEP87_RS07130 ENOG4105CC9 acyl-Coa dehydrogenase HEP87_RS07140 ENOG4105CC9 acyl-Coa dehydrogenase HEP87_RS07155 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS07160 ENOG4105CYC Transferase HEP87_RS07170 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP87_RS07180 ENOG4107YCY Transcriptional regulator HEP87_RS07185 ENOG4108R85 Short chain dehydrogenase HEP87_RS07200 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS07220 ENOG4105D3W isochorismatase HEP87_RS07325 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HEP87_RS07330 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP87_RS07335 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP87_RS07345 ENOG4105C0X amino acid HEP87_RS07415 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HEP87_RS07430 ENOG4108IUW ABC transporter HEP87_RS07435 ENOG41068W2 Cytochrome p-450 HEP87_RS07445 ENOG4105JZI cytochrome P450 HEP87_RS07450 ENOG4108X7A Terpene synthase metal-binding domain-containing protein HEP87_RS07455 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP87_RS07490 ENOG4105C3M thioredoxin reductase HEP87_RS07565 ENOG4107TPY serine threonine protein kinase HEP87_RS07620 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HEP87_RS07650 ENOG4107TDF Formate hydrogenlyase subunit 4 HEP87_RS07695 ENOG4105CHH sulfate transporter HEP87_RS07705 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HEP87_RS07750 ENOG4105CV8 reductase HEP87_RS07775 ENOG4108R85 Short chain dehydrogenase HEP87_RS07800 ENOG4105JZI cytochrome P450 HEP87_RS07860 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HEP87_RS08110 ENOG4105CPC Aldo Keto reductase HEP87_RS08115 ENOG4105F95 Monooxygenase HEP87_RS08130 ENOG4108JA1 polyketide synthase HEP87_RS08200 ENOG4105XPP Protein of unknown function (DUF1275) HEP87_RS08240 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP87_RS08260 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEP87_RS08300 ENOG4107SCA Formamidase (EC 3.5.1.49) HEP87_RS08305 ENOG4105IW1 AmiS UreI transporter HEP87_RS08315 ENOG41083TI Protein CrcB homolog HEP87_RS08335 ENOG4105CMT Dihydroxyacetone kinase HEP87_RS08340 ENOG4108UTZ Dihydroxyacetone kinase HEP87_RS08355 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP87_RS08385 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP87_RS08390 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP87_RS08440 ENOG4105I82 acetyl xylan esterase HEP87_RS08465 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP87_RS08470 ENOG4105CG3 alpha amylase, catalytic region HEP87_RS08475 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP87_RS08530 ENOG4105ERH Fumarylacetoacetate hydrolase HEP87_RS08545 ENOG4105CHP RNA polymerase HEP87_RS08555 ENOG4105GRZ Ycii-related protein HEP87_RS08570 ENOG4105CHR reductase HEP87_RS08580 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HEP87_RS08605 ENOG4105CSV Glutaminase HEP87_RS08610 ENOG4108IJ0 Aspartate ammonia-lyase HEP87_RS08640 ENOG4105KJJ Uncharacterized ACR, COG1993 HEP87_RS08645 ENOG41083YR Protein CrcB homolog HEP87_RS08670 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP87_RS08680 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS08695 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HEP87_RS08705 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HEP87_RS08720 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP87_RS08725 ENOG4105E2Y ABC, transporter HEP87_RS08770 ENOG4105EDW glycosyl transferase, family 39 HEP87_RS08810 ENOG4107RRZ synthase HEP87_RS08845 ENOG4105MVE transcriptional regulator HEP87_RS08870 ENOG4107R34 abc transporter permease protein HEP87_RS08875 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP87_RS08895 ENOG41080QX K07048 phosphotriesterase-related protein HEP87_RS08910 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) HEP87_RS08930 ENOG4105D2N Aldolase HEP87_RS08935 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP87_RS08940 ENOG4105E98 transcriptional regulator DeoR family HEP87_RS08950 ENOG4108IJ8 ABC transporter HEP87_RS08955 ENOG4105E90 ABC transporter HEP87_RS08975 ENOG4105GWZ Roadblock lc7 family protein HEP87_RS08995 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP87_RS09005 ENOG4107P5I polyketide synthase HEP87_RS09035 ENOG4108VQT Alpha beta hydrolase fold protein HEP87_RS09040 ENOG4108MRH transcriptional regulatory protein HEP87_RS09045 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEP87_RS09050 ENOG4105D7T ABC transporter HEP87_RS09055 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HEP87_RS09085 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HEP87_RS09090 ENOG4105C4M (Ubiquinol oxidase) subunit I HEP87_RS09100 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEP87_RS09145 ENOG4105BZP glycoside hydrolase 15-related HEP87_RS09185 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS09190 ENOG4105BZU Histidine kinase HEP87_RS09205 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HEP87_RS09210 ENOG4107PP3 Acetylornithine deacetylase HEP87_RS09215 ENOG4105I1F Resistance protein HEP87_RS09230 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP87_RS09325 ENOG41060NJ transcriptional regulator HEP87_RS09345 ENOG4105C10 Electron transfer flavoprotein HEP87_RS09370 ENOG4105PSQ Acyl-transferase HEP87_RS09395 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HEP87_RS09480 ENOG4105YVS arsR family transcriptional regulator HEP87_RS09485 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP87_RS09500 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS09505 ENOG4105BZU Histidine kinase HEP87_RS09520 ENOG4105DBE peroxidase HEP87_RS09525 ENOG410650H (LipO)protein HEP87_RS09535 ENOG4105CRK lysyL-tRNA synthetase HEP87_RS09550 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEP87_RS09560 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP87_RS09570 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS09595 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HEP87_RS09630 ENOG4105EBM Alpha Beta Hydrolase Fold protein HEP87_RS09635 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HEP87_RS09640 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP87_RS09645 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HEP87_RS09655 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HEP87_RS09705 ENOG4105C7W Xanthine dehydrogenase HEP87_RS09715 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HEP87_RS09730 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEP87_RS09760 ENOG4105ETX regulatoR HEP87_RS09820 ENOG4105V9V Short-chain dehydrogenase reductase Sdr HEP87_RS09875 ENOG4105EMU Dehydrogenase HEP87_RS09900 ENOG4105C1J atp-dependent rna helicase HEP87_RS09935 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HEP87_RS09945 ENOG4105Q33 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency HEP87_RS09955 ENOG4107ZED Uncharacterised protein family UPF0047 HEP87_RS09960 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP87_RS09965 ENOG4105E2Y ABC, transporter HEP87_RS09975 ENOG4105H3G oxidoreductase HEP87_RS09985 ENOG4105BZ1 (ABC) transporter HEP87_RS09995 ENOG4105CK2 sodium dicarboxylate symporter HEP87_RS10015 ENOG4105BZ1 (ABC) transporter HEP87_RS10040 ENOG4105C29 acyl-CoA thioesterase HEP87_RS10050 ENOG4105GWZ Roadblock lc7 family protein HEP87_RS10080 ENOG4105BZU Histidine kinase HEP87_RS10120 ENOG4105C0D helicase HEP87_RS10140 ENOG4105C93 Xylose Isomerase HEP87_RS10150 ENOG4105E2R ROK family HEP87_RS10155 ENOG4105C85 amino acid HEP87_RS10160 ENOG4107SCA Formamidase (EC 3.5.1.49) HEP87_RS10170 ENOG4107RR1 TRANSCRIPTIONal HEP87_RS10175 ENOG4105C26 Dehydrogenase HEP87_RS10220 ENOG4108UGD Serine Threonine protein kinase HEP87_RS10250 ENOG4105D2B acyl-CoA dehydrogenase HEP87_RS10255 ENOG4105D2B acyl-CoA dehydrogenase HEP87_RS10260 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP87_RS10270 ENOG4105C3M thioredoxin reductase HEP87_RS10275 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HEP87_RS10285 ENOG4105C26 Dehydrogenase HEP87_RS10300 ENOG41065KQ synthase HEP87_RS10305 ENOG4106A3M Cytochrome p-450 HEP87_RS10315 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS10325 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HEP87_RS10335 ENOG4105F1K Glutamine amidotransferase HEP87_RS10340 ENOG4105CTQ phosphohexokinase HEP87_RS10370 ENOG4108HRK Histidine kinase HEP87_RS10385 ENOG4108NEV two component transcriptional regulator, LytTR family HEP87_RS10400 ENOG4105C8Y Acetylornithine aminotransferase HEP87_RS10410 ENOG410600Z Regulatory protein MarR HEP87_RS10420 ENOG4105KVH Transcriptional regulator HEP87_RS10435 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HEP87_RS10465 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HEP87_RS10475 ENOG4105CQM Urea amidohydrolase subunit alpha HEP87_RS10480 ENOG4105KI2 Urea amidohydrolase subunit beta HEP87_RS10485 ENOG4108YZ9 Urea amidohydrolase subunit gamma HEP87_RS10530 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HEP87_RS10535 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEP87_RS10580 ENOG4105FBW Monooxygenase HEP87_RS10585 ENOG4108R6G acetyltransferase HEP87_RS10605 ENOG4105CBC glutamate synthase HEP87_RS10660 ENOG4105C83 adenylosuccinate lyase HEP87_RS10665 ENOG4108VCA G U mismatch-specific DNA glycosylase HEP87_RS10685 ENOG4105BZU Histidine kinase HEP87_RS10690 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS10695 ENOG4105DKQ ROK family HEP87_RS10700 ENOG4105FDP GntR family transcriptional regulator HEP87_RS10705 ENOG4108KPJ rna polymerase sigma factor HEP87_RS10755 ENOG4107RSM transcriptional regulator HEP87_RS10775 ENOG4107RFY SbcCD D subunit HEP87_RS10780 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HEP87_RS10800 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS10825 ENOG4105CPC Aldo Keto reductase HEP87_RS10830 ENOG4105K4P CoA-binding domain protein HEP87_RS10865 ENOG4105CSR polyphosphate kinase 2 HEP87_RS10870 ENOG41082SX arsR family transcriptional regulator HEP87_RS10895 ENOG4108UW5 maltose o-acetyltransferase HEP87_RS10900 ENOG4108Z0R Transferase HEP87_RS10930 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS10995 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HEP87_RS11000 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HEP87_RS11005 ENOG4108XHQ (2Fe-2S)-binding domain protein HEP87_RS11010 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HEP87_RS11040 ENOG4108HMN Caspase domain HEP87_RS11085 ENOG4105K4H Nlp p60 protein HEP87_RS11150 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HEP87_RS11310 ENOG4105DZH s-adenosylmethionine synthetase (EC 2.5.1.6) HEP87_RS11325 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HEP87_RS11330 ENOG4105CS1 NAD(P)H quinone oxidoreductase HEP87_RS11340 ENOG4105D9P serine threonine protein kinase HEP87_RS11345 ENOG4108I5C dEAD DEAH box helicase HEP87_RS11350 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HEP87_RS11355 ENOG4105CVR type I restriction-modification system HEP87_RS11410 ENOG4105C7H Helicase, RecD TraA family HEP87_RS11460 ENOG4105EC2 ftsk spoIIIe HEP87_RS11635 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEP87_RS11650 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS11675 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HEP87_RS11695 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEP87_RS11710 ENOG4105DEN Luciferase family HEP87_RS11720 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HEP87_RS11725 ENOG4105EP9 oxidoreductase HEP87_RS11740 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HEP87_RS11745 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HEP87_RS11750 ENOG4105CHR reductase HEP87_RS11790 ENOG4108Q5Y Membrane HEP87_RS11795 ENOG4105CSW GntR family transcriptional regulator HEP87_RS11830 ENOG4105NTW Transcriptional regulator HEP87_RS11865 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HEP87_RS11875 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEP87_RS11895 ENOG4108UW8 fha domain-containing protein HEP87_RS11945 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HEP87_RS11960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP87_RS11965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP87_RS11975 ENOG4105E09 nadh pyrophosphatase HEP87_RS11980 ENOG4108UQS dipeptidase HEP87_RS11990 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP87_RS11995 ENOG4105BZU Histidine kinase HEP87_RS12000 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP87_RS12005 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP87_RS12025 ENOG4105GWZ Roadblock lc7 family protein HEP87_RS12075 ENOG4105CFM UPF0317 protein HEP87_RS12080 ENOG4105E7W lamb ycsf family protein HEP87_RS12090 ENOG4107R7A Allophanate hydrolase subunit 2 HEP87_RS12095 ENOG41090WU lipolytic protein G-D-S-L family HEP87_RS12100 ENOG4108MJN Glycosyl Transferase HEP87_RS12115 ENOG4105JXB ankyrin repeat-containing protein HEP87_RS12130 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP87_RS12145 ENOG4105DEU major facilitator superfamily HEP87_RS12150 ENOG4105Q70 HEP87_RS12160 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HEP87_RS12165 ENOG4105CD3 dihydroorotase HEP87_RS12170 ENOG4105EW9 transcriptional regulator AsnC family HEP87_RS12190 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS12200 ENOG4107Z3H Transcriptional regulator, TetR family HEP87_RS12245 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HEP87_RS12250 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HEP87_RS12255 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HEP87_RS12260 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HEP87_RS12280 ENOG4106UW1 Major Facilitator superfamily HEP87_RS12295 ENOG4105C2W permease HEP87_RS12310 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP87_RS12340 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HEP87_RS12345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP87_RS12365 ENOG4108TZY GntR Family Transcriptional Regulator HEP87_RS12375 ENOG4105CUB amino acid HEP87_RS12395 ENOG4105DKT Transcriptional regulator HEP87_RS12400 ENOG4105DJV ribulose-phosphate 3-epimerase HEP87_RS12410 ENOG4107QN2 dihydrolipoyl dehydrogenase HEP87_RS12425 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HEP87_RS12440 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HEP87_RS12455 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HEP87_RS12465 ENOG4105SKN orotidine 5''-phosphate decarboxylase HEP87_RS12470 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HEP87_RS12475 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HEP87_RS12480 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HEP87_RS12490 ENOG4105CD3 dihydroorotase HEP87_RS12495 ENOG4105CXT aspartate transcarbamylase HEP87_RS12500 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HEP87_RS12510 ENOG410803B Involved in the transcription termination process (By similarity) HEP87_RS12515 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HEP87_RS12535 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HEP87_RS12540 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HEP87_RS12550 ENOG4105HHA aminodeoxychorismate lyase HEP87_RS12555 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HEP87_RS12560 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HEP87_RS12580 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HEP87_RS12595 ENOG4105CJ1 ABC, transporter HEP87_RS12605 ENOG4105BZU Histidine kinase HEP87_RS12610 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS12615 ENOG4105CUT histidyl-tRNA synthetase HEP87_RS12625 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HEP87_RS12630 ENOG4105C99 atpase involved in dna repair HEP87_RS12645 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HEP87_RS12650 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEP87_RS12655 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEP87_RS12665 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HEP87_RS12670 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HEP87_RS12675 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HEP87_RS12680 ENOG4105CDY transcriptional regulatory protein HEP87_RS12685 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HEP87_RS12690 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HEP87_RS12700 ENOG4105E6M Sulphatase-modifying factor protein HEP87_RS12705 ENOG4105E2K Glycosyl transferase (Group 1 HEP87_RS12740 ENOG4105C22 threonyL-tRNA synthetase HEP87_RS12755 ENOG4108IRC dna polymerase iii HEP87_RS12775 ENOG4105EKC HEP87_RS12785 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HEP87_RS12790 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP87_RS12810 ENOG4105KF0 sporulation and cell division protein, SsgA HEP87_RS12840 ENOG4105F0I Aminotransferase HEP87_RS12845 ENOG4105CRQ synthase (Component I) HEP87_RS12910 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HEP87_RS12925 ENOG4105D01 (LipO)protein HEP87_RS12930 ENOG4108UMI ABC transporter, permease HEP87_RS12935 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEP87_RS12975 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS12985 ENOG4105RJZ Transcriptional regulator HEP87_RS12995 ENOG4105CH7 arginosuccinase HEP87_RS13000 ENOG4105CDH Citrulline--aspartate ligase HEP87_RS13025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS13055 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HEP87_RS13060 ENOG4105C8Y Acetylornithine aminotransferase HEP87_RS13065 ENOG4105CAS nag kinase HEP87_RS13070 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HEP87_RS13075 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HEP87_RS13100 ENOG4105VUF Transcriptional regulator HEP87_RS13150 ENOG4105T38 integral membrane protein HEP87_RS13160 ENOG4105F32 YngK protein HEP87_RS13185 ENOG4108UGD Serine Threonine protein kinase HEP87_RS13210 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HEP87_RS13215 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HEP87_RS13220 ENOG4105BZU Histidine kinase HEP87_RS13225 ENOG4108RWN rrna methyltransferase HEP87_RS13230 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HEP87_RS13235 ENOG41084BS 50S ribosomal protein L35 HEP87_RS13240 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HEP87_RS13325 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP87_RS13345 ENOG4105C26 Dehydrogenase HEP87_RS13350 ENOG4105C5F glutamine synthetase HEP87_RS13400 ENOG4105CPC Aldo Keto reductase HEP87_RS13420 ENOG4108HQS Glycine betaine HEP87_RS13425 ENOG4108IJ7 Glycine betaine HEP87_RS13430 ENOG4105HFS 5'-3' exonuclease HEP87_RS13460 ENOG4105D3G Pseudouridine synthase HEP87_RS13490 ENOG4105MKU Transcriptional regulator HEP87_RS13530 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HEP87_RS13535 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEP87_RS13565 ENOG4108V1T peptidylprolyl cis-trans isomerase HEP87_RS13570 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HEP87_RS13580 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS13585 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HEP87_RS13590 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HEP87_RS13600 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HEP87_RS13605 ENOG4105E5F proteasome HEP87_RS13610 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HEP87_RS13645 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS13655 ENOG4108J59 Extracellular solute-binding protein, family 5 HEP87_RS13660 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HEP87_RS13665 ENOG4105C3R Methionine synthase HEP87_RS13670 ENOG4108K8U Glycerol operon regulatory protein HEP87_RS13675 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP87_RS13680 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP87_RS13700 ENOG4105JXH GntR family transcriptional regulator HEP87_RS13725 ENOG4105C8N cysteinyl-tRNA synthetase HEP87_RS13745 ENOG4105D7N magnesium and cobalt transport protein CorA HEP87_RS13755 ENOG4105DYW oxidoreductase HEP87_RS13760 ENOG4105CPC Aldo Keto reductase HEP87_RS13780 ENOG4105S2J secreted protein HEP87_RS13790 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HEP87_RS13805 ENOG4105CD8 aminopeptidase N HEP87_RS13810 ENOG4105K5B UPF0225 protein HEP87_RS13815 ENOG4105C6F GntR Family Transcriptional Regulator HEP87_RS13820 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEP87_RS13825 ENOG4105C6Z Gluconate HEP87_RS13830 ENOG4105CHR reductase HEP87_RS13860 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein HEP87_RS13870 ENOG4105PTV Nudix Hydrolase HEP87_RS13875 ENOG4105VG5 Membrane HEP87_RS13895 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS13900 ENOG4108IG5 Transcriptional regulator HEP87_RS13905 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS13915 ENOG4105EHZ conserved protein UCP016719 HEP87_RS13935 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HEP87_RS13940 ENOG4108Z4X TRANSCRIPTIONal HEP87_RS13960 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS13970 ENOG4108ZHR arsR family transcriptional regulator HEP87_RS13975 ENOG4107Y9U Membrane HEP87_RS14000 ENOG4105D4T Citrate transporter HEP87_RS14005 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEP87_RS14010 ENOG4108SGK Tetr family transcriptional regulator HEP87_RS14020 ENOG4105F1J Homogentisate 1,2-dioxygenase HEP87_RS14055 ENOG4105RNG membrane HEP87_RS14065 ENOG4105K6V RNA polymerase HEP87_RS14080 ENOG41061MD high-affinity nickel-transporter HEP87_RS14085 ENOG4105D9P serine threonine protein kinase HEP87_RS14090 ENOG4108TCJ secreted hydrolase HEP87_RS14095 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP87_RS14115 ENOG4107BJW polysaccharide deacetylase HEP87_RS14140 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HEP87_RS14155 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP87_RS14180 ENOG4108Z2K Cupin 2, conserved barrel domain protein HEP87_RS14185 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEP87_RS14190 ENOG4105C0B DNA polymerase III (alpha subunit) HEP87_RS14205 ENOG4106NMR serine protease HEP87_RS14225 ENOG4105CDA abc transporter atp-binding protein HEP87_RS14235 ENOG4108HW4 amino acid AbC transporter HEP87_RS14240 ENOG4105EAB amino acid AbC transporter HEP87_RS14250 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HEP87_RS14255 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS14260 ENOG4105C57 major facilitator superfamily HEP87_RS14270 ENOG410841Q phosphoesterase PA-phosphatase related protein HEP87_RS14280 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEP87_RS14315 ENOG4108IV0 ABC, transporter HEP87_RS14320 ENOG4106839 domain protein HEP87_RS14340 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HEP87_RS14350 ENOG4105CAT Cytidine monophosphate kinase HEP87_RS14390 ENOG410756H nucleotidyltransferase HEP87_RS14395 ENOG41065RQ ADP-ribosylation crystallin J1 HEP87_RS14405 ENOG4105FE9 pseudouridine synthase HEP87_RS14410 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HEP87_RS14430 ENOG4105DCF alanine dehydrogenase HEP87_RS14440 ENOG4108YZ4 nudix hydrolase HEP87_RS14445 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HEP87_RS14450 ENOG4105BZP glycoside hydrolase 15-related HEP87_RS14465 ENOG4108MJN Glycosyl Transferase HEP87_RS14470 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HEP87_RS14475 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HEP87_RS14495 ENOG4105E0A ABC, transporter HEP87_RS14500 ENOG4105TVJ transport system, permease HEP87_RS14505 ENOG4105DQ5 transport system permease protein HEP87_RS14510 ENOG4105DSU hydrolase HEP87_RS14540 ENOG4108VX5 3-methyladenine DNA glycosylase HEP87_RS14550 ENOG4108V1U phospholipid-binding protein HEP87_RS14570 ENOG4105DKW ABC transporter HEP87_RS14585 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS14590 ENOG4105ENE Histidine kinase HEP87_RS14600 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HEP87_RS14610 ENOG4105IDI abc transporter atp-binding protein HEP87_RS14620 ENOG4105EAC phosphoserine phosphatase HEP87_RS14625 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP87_RS14640 ENOG4107YCY Transcriptional regulator HEP87_RS14655 ENOG4105CHR reductase HEP87_RS14670 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HEP87_RS14690 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP87_RS14695 ENOG4107QN1 sodium solute HEP87_RS14765 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEP87_RS14795 ENOG4108DT4 serine threonine protein kinase HEP87_RS14820 ENOG4105BZP glycoside hydrolase 15-related HEP87_RS14850 ENOG4105VBF alkaline shock protein HEP87_RS14870 ENOG4105C5H ABC transporter HEP87_RS14900 ENOG4107W7X Aldolase HEP87_RS14925 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HEP87_RS14930 ENOG4105CTK cobaltochelatase, cobn subunit HEP87_RS14940 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HEP87_RS14945 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HEP87_RS14960 ENOG4105CIA precorrin-4 C(11)-methyltransferase HEP87_RS14970 ENOG4105E4R Precorrin-3B C17-methyltransferase HEP87_RS14975 ENOG41081F0 Precorrin-8x methylmutase HEP87_RS15000 ENOG4105CDA abc transporter atp-binding protein HEP87_RS15005 ENOG4105DRP amino acid AbC transporter HEP87_RS15010 ENOG4106PMH Extracellular solute-binding protein family 3 HEP87_RS15015 ENOG4105C5R Aminotransferase HEP87_RS15025 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HEP87_RS15030 ENOG4108JPW Aminotransferase HEP87_RS15035 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HEP87_RS15040 ENOG4105EV8 ectoine hydroxylase HEP87_RS15070 ENOG4107HP6 Transcriptional regulator HEP87_RS15080 ENOG4105CJN penicillin-binding protein HEP87_RS15085 ENOG4105C7N Xanthine uracil vitamin C permease HEP87_RS15090 ENOG4105NAF rna polymerase sigma factor HEP87_RS15105 ENOG4108J21 pectate lyase HEP87_RS15155 ENOG4108J20 pectate lyase HEP87_RS15160 ENOG4107TDE lipolytic protein G-D-S-L family HEP87_RS15165 ENOG4107T3P ABC, transporter HEP87_RS15200 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP87_RS15205 ENOG4105DRR Transcriptional regulator, GntR family HEP87_RS15230 ENOG4105E9Z Nad-dependent epimerase dehydratase HEP87_RS15235 ENOG4105E98 transcriptional regulator DeoR family HEP87_RS15255 ENOG4105CPQ Dehydrogenase HEP87_RS15265 ENOG4105XEA Tetr family transcriptional regulator HEP87_RS15280 ENOG4107XBN GntR Family Transcriptional Regulator HEP87_RS15325 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP87_RS15335 ENOG4105NAF rna polymerase sigma factor HEP87_RS15345 ENOG4105EEM helicase HEP87_RS15350 ENOG4105E2A Dehydrogenase HEP87_RS15355 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HEP87_RS15360 ENOG4108RFG Tetr family transcriptional regulator HEP87_RS15365 ENOG410814C multidrug resistance protein HEP87_RS15385 ENOG4108UNV SUF system FeS assembly protein, NifU family HEP87_RS15390 ENOG4105C9B Cysteine desulfurase HEP87_RS15395 ENOG4105C3K feS assembly ATPase SufC HEP87_RS15405 ENOG4105JRK feS assembly protein SufD HEP87_RS15420 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HEP87_RS15425 ENOG4105CJ1 ABC, transporter HEP87_RS15450 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HEP87_RS15460 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEP87_RS15480 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HEP87_RS15500 ENOG4107T3P ABC, transporter HEP87_RS15505 ENOG4105U3E Transcriptional regulator HEP87_RS15510 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP87_RS15525 ENOG4107QP8 phosphohexose isomerase HEP87_RS15530 ENOG4105C6X Major Facilitator HEP87_RS15545 ENOG4105CP7 Triose-phosphate isomerase HEP87_RS15550 ENOG4105BZA Phosphoglycerate kinase HEP87_RS15555 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEP87_RS15565 ENOG4105CIE May be required for sporulation (By similarity) HEP87_RS15570 ENOG4105CHW UPF0052 protein HEP87_RS15575 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HEP87_RS15580 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HEP87_RS15595 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS15605 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEP87_RS15620 ENOG4107R0W ABC transporter HEP87_RS15625 ENOG4105E5Q amino acid AbC transporter HEP87_RS15635 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HEP87_RS15640 ENOG4105CSH Transporter HEP87_RS15665 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HEP87_RS15670 ENOG4105BZU Histidine kinase HEP87_RS15675 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HEP87_RS15680 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEP87_RS15700 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HEP87_RS15710 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP87_RS15715 ENOG4105D7N magnesium and cobalt transport protein CorA HEP87_RS15745 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP87_RS15750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP87_RS15795 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP87_RS15830 ENOG4105DRR Transcriptional regulator, GntR family HEP87_RS15845 ENOG4105D9G High-affinity HEP87_RS15875 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HEP87_RS15895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP87_RS15940 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HEP87_RS15950 ENOG4105C32 Amino acid ABC transporter (Permease) HEP87_RS15955 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HEP87_RS15960 ENOG4105C0Z ABC transporter HEP87_RS15965 ENOG4108IV0 ABC, transporter HEP87_RS16000 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HEP87_RS16020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS16025 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HEP87_RS16030 ENOG41063TF transcriptional regulator (AraC HEP87_RS16055 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HEP87_RS16065 ENOG41060WC Enoyl-CoA hydratase HEP87_RS16080 ENOG4105EA8 2-Nitropropane dioxygenase HEP87_RS16085 ENOG4105F2C Acetyl-CoA acetyltransferase HEP87_RS16090 ENOG4108RZE Tetr family transcriptional regulator HEP87_RS16100 ENOG4105D2B acyl-CoA dehydrogenase HEP87_RS16105 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS16110 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP87_RS16115 ENOG41090B9 response to stress HEP87_RS16120 ENOG4105MUA Resistance protein HEP87_RS16135 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP87_RS16190 ENOG4108RVA ribokinase HEP87_RS16195 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP87_RS16200 ENOG4105CI0 Citrate lyase HEP87_RS16215 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HEP87_RS16220 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HEP87_RS16230 ENOG4105DK0 Indole-3-glycerol phosphate synthase HEP87_RS16255 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HEP87_RS16275 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HEP87_RS16280 ENOG4108176 endoribonuclease L-psp HEP87_RS16285 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HEP87_RS16290 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HEP87_RS16300 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HEP87_RS16305 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP87_RS16310 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HEP87_RS16330 ENOG4108Z66 YbaK ebsC protein HEP87_RS16365 ENOG4105C0B DNA polymerase III (alpha subunit) HEP87_RS16410 ENOG41082BV acetyltransferase HEP87_RS16420 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HEP87_RS16435 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HEP87_RS16440 ENOG4107VQS DivIVA family HEP87_RS16450 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HEP87_RS16455 ENOG4105DFA alanine racemase domain protein HEP87_RS16460 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HEP87_RS16465 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HEP87_RS16475 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HEP87_RS16485 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HEP87_RS16490 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HEP87_RS16500 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HEP87_RS16505 ENOG4105CJN penicillin-binding protein HEP87_RS16515 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HEP87_RS16525 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HEP87_RS16545 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HEP87_RS16555 ENOG4105CDA abc transporter atp-binding protein HEP87_RS16565 ENOG4107Z3H Transcriptional regulator, TetR family HEP87_RS16575 ENOG4105EWK phytoene HEP87_RS16590 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HEP87_RS16615 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HEP87_RS16625 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HEP87_RS16635 ENOG4108UQY Iron-storage protein HEP87_RS16645 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HEP87_RS16665 ENOG4105CTQ phosphohexokinase HEP87_RS16670 ENOG4108Q9V regulatoR HEP87_RS16675 ENOG4105ENE Histidine kinase HEP87_RS16745 ENOG4105UQX Mate efflux family protein HEP87_RS16790 ENOG4105C9B Cysteine desulfurase HEP87_RS16795 ENOG4108I0Q anthranilate phosphoribosyltransferase HEP87_RS16800 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP87_RS16805 ENOG4107EUI c reductase, iron-sulfur HEP87_RS16810 ENOG4107UDY cytochrome C HEP87_RS16815 ENOG4105CCU oxidase (Subunit III) HEP87_RS16825 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HEP87_RS16830 ENOG4105MCD Part of cytochrome c oxidase, its function is HEP87_RS16835 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEP87_RS16840 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HEP87_RS16850 ENOG4107T4Z adenosine kinase HEP87_RS16870 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HEP87_RS16875 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS16900 ENOG4105DXX methyltransferase HEP87_RS16905 ENOG4105C0H protease HEP87_RS16930 ENOG4105CRK lysyL-tRNA synthetase HEP87_RS16950 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HEP87_RS17025 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEP87_RS17030 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HEP87_RS17050 ENOG4105C5F glutamine synthetase HEP87_RS17060 ENOG4105D0M Protease HtpX homolog HEP87_RS17100 ENOG4108222 arsenate reductase HEP87_RS17105 ENOG4106SPC secreted protein HEP87_RS17110 ENOG4107R5B glutamine synthetase HEP87_RS17115 ENOG4107NHD transcriptional regulator HEP87_RS17130 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS17160 ENOG41060BG Tetr family transcriptional regulator HEP87_RS17210 ENOG4105EG2 ABC transporter, permease HEP87_RS17215 ENOG4105CG3 alpha amylase, catalytic region HEP87_RS17220 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS17235 ENOG4105CUB amino acid HEP87_RS17245 ENOG4107RSM transcriptional regulator HEP87_RS17250 ENOG4105FDR Membrane HEP87_RS17255 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HEP87_RS17260 ENOG4105FBN Acid phosphatase HEP87_RS17345 ENOG4105GFG DUF218 domain HEP87_RS17355 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEP87_RS17360 ENOG4105C5F glutamine synthetase HEP87_RS17365 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP87_RS17370 ENOG41081JD Transcriptional regulator HEP87_RS17390 ENOG4105C4K Nad synthetase HEP87_RS17395 ENOG4105F27 Major Facilitator HEP87_RS17410 ENOG4105C57 major facilitator superfamily HEP87_RS17415 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HEP87_RS17435 ENOG4107XZ0 Peptidase M50 HEP87_RS17485 ENOG410650H (LipO)protein HEP87_RS17490 ENOG4105DBE peroxidase HEP87_RS17500 ENOG4106A0S HEP87_RS17505 ENOG4105C8T Leucyl-tRNA synthetase HEP87_RS17515 ENOG4105CIK Amidinotransferase HEP87_RS17525 ENOG4107S1E Beta-lactamase HEP87_RS17530 ENOG4105C2C drug resistance transporter, Bcr CflA HEP87_RS17540 ENOG4105CHR reductase HEP87_RS17555 ENOG4105C19 ABC transporter HEP87_RS17565 ENOG4108VGI doxx family HEP87_RS17580 ENOG4105GCF PGAM HEP87_RS17585 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS17590 ENOG4105CHR reductase HEP87_RS17665 ENOG4105D8K carboxyl transferase HEP87_RS17675 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS17685 ENOG4107SCK Monooxygenase HEP87_RS17725 ENOG4108W5M transcriptional regulator HEP87_RS17730 ENOG4105CHR reductase HEP87_RS17770 ENOG4108IG5 Transcriptional regulator HEP87_RS17775 ENOG41064MX Tetr family transcriptional regulator HEP87_RS17890 ENOG4105E7U AraC family transcriptional regulator HEP87_RS17910 ENOG4107XFJ UPF0246 protein HEP87_RS17915 ENOG4108UHU Aldolase HEP87_RS17920 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP87_RS17940 ENOG4105EGD dinuclear metal center protein, YbgI family HEP87_RS17965 ENOG4105CHR reductase HEP87_RS17980 ENOG4108M15 ABC transporter HEP87_RS18035 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HEP87_RS18045 ENOG4105DYW oxidoreductase HEP87_RS18065 ENOG4107QVI Methyltransferase, type 11 HEP87_RS18075 ENOG4108SGK Tetr family transcriptional regulator HEP87_RS18110 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HEP87_RS18150 ENOG4105XPP Protein of unknown function (DUF1275) HEP87_RS18185 ENOG4105F2C Acetyl-CoA acetyltransferase HEP87_RS18190 ENOG4106A3M Cytochrome p-450 HEP87_RS18205 ENOG4105CSH Transporter HEP87_RS18290 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEP87_RS18295 ENOG4105D3W isochorismatase HEP87_RS18300 ENOG41080V3 Major Facilitator superfamily HEP87_RS18320 ENOG4105KVH Transcriptional regulator HEP87_RS18440 ENOG4105D9P serine threonine protein kinase HEP87_RS18500 ENOG4105BZ4 penicillin-binding protein HEP87_RS18515 ENOG4105DAX Pfam:DUF2983 HEP87_RS18560 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HEP87_RS18565 ENOG4105EYW Ion transport protein HEP87_RS18590 ENOG4105CPC Aldo Keto reductase HEP87_RS18595 ENOG4105VUF Transcriptional regulator HEP87_RS18625 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP87_RS18630 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP87_RS18650 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HEP87_RS18665 ENOG4108R86 Transcriptional regulator HEP87_RS18680 ENOG4106KE4 Dehydrogenase HEP87_RS18685 ENOG4105DUM transcriptional regulator, lysR family HEP87_RS18690 ENOG4105NGS secreted protein HEP87_RS18695 ENOG4105EXN Sulfate transport protein CysZ HEP87_RS18710 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP87_RS18715 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEP87_RS18745 ENOG4105DFW ABC transporter HEP87_RS18755 ENOG4108HWW ABC transporter HEP87_RS18760 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HEP87_RS18765 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP87_RS18800 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP87_RS18830 ENOG4108YIQ Alpha beta hydrolase HEP87_RS18875 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HEP87_RS18885 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP87_RS18895 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HEP87_RS18900 ENOG41069M3 Transcriptional regulator HEP87_RS18990 ENOG4105ENX hydrolase HEP87_RS19030 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP87_RS19035 ENOG4105DFF Rod shape-determining protein mreb HEP87_RS19105 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP87_RS19110 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HEP87_RS19120 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HEP87_RS19130 ENOG4107GZ4 SanA protein HEP87_RS19180 ENOG4107QZF nitrite reductase NADPH large subunit HEP87_RS19190 ENOG4108XFH Transcriptional regulator HEP87_RS19195 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP87_RS19200 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP87_RS19210 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP87_RS19220 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HEP87_RS19225 ENOG4105E2R ROK family HEP87_RS19265 ENOG4105NAF rna polymerase sigma factor HEP87_RS19300 ENOG4105CPC Aldo Keto reductase HEP87_RS19310 ENOG4108SGK Tetr family transcriptional regulator HEP87_RS19315 ENOG4105E1F short-chain dehydrogenase reductase HEP87_RS19320 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HEP87_RS19325 ENOG4105DSE periplasmic solute binding protein HEP87_RS19330 ENOG4105FDK ABC transporter HEP87_RS19350 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HEP87_RS19380 ENOG4108762 serine threonine protein kinase HEP87_RS19385 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS19390 ENOG4105BZU Histidine kinase HEP87_RS19405 ENOG4105JXH GntR family transcriptional regulator HEP87_RS19410 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP87_RS19420 ENOG4105C3U ABC transporter HEP87_RS19425 ENOG4108JQ7 (ABC) transporter HEP87_RS19430 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP87_RS19445 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HEP87_RS19455 ENOG4105D4Y metalloprotease HEP87_RS19505 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HEP87_RS19525 ENOG4105MSB protein, conserved in bacteria HEP87_RS19535 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HEP87_RS19560 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HEP87_RS19565 ENOG4107YU2 histidine triad (hIT) protein HEP87_RS19590 ENOG4107QWG 2-Nitropropane dioxygenase HEP87_RS19595 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HEP87_RS19600 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HEP87_RS19625 ENOG4105BZU Histidine kinase HEP87_RS19640 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HEP87_RS19650 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HEP87_RS19805 ENOG4105CFI type iii restriction protein res subunit HEP87_RS19850 ENOG4105EPR degv family HEP87_RS19860 ENOG4105C8T Leucyl-tRNA synthetase HEP87_RS19870 ENOG4107QIZ NADH dehydrogenase HEP87_RS19910 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP87_RS19925 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HEP87_RS19940 ENOG4105D0M Protease HtpX homolog HEP87_RS19955 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HEP87_RS19965 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HEP87_RS19995 ENOG4105DGI Alkaline phosphatase HEP87_RS20000 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HEP87_RS20005 ENOG4105K46 50S ribosomal protein l27 HEP87_RS20010 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HEP87_RS20050 ENOG4107GJV short-chain dehydrogenase reductase HEP87_RS20090 ENOG4105CNI cell division protein FtsW HEP87_RS20095 ENOG4105CJN penicillin-binding protein HEP87_RS20110 ENOG4105DFF Rod shape-determining protein mreb HEP87_RS20115 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HEP87_RS20125 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HEP87_RS20130 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HEP87_RS20140 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HEP87_RS20145 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP87_RS20150 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP87_RS20155 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HEP87_RS20175 ENOG4108TGC Acyltransferase HEP87_RS20225 ENOG4105E2R ROK family HEP87_RS20235 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP87_RS20240 ENOG4105E2Y ABC, transporter HEP87_RS20255 ENOG4105C85 amino acid HEP87_RS20260 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEP87_RS20265 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP87_RS20275 ENOG4105MC2 DSBA oxidoreductase HEP87_RS20310 ENOG4108UYE Lactoylglutathione lyase HEP87_RS20320 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP87_RS20375 ENOG4108KTG Membrane protein, drug metabolite transporter HEP87_RS20390 ENOG4107SCK Monooxygenase HEP87_RS20420 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP87_RS20435 ENOG4105D8X mechanosensitive ion channel HEP87_RS20490 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HEP87_RS20495 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HEP87_RS20500 ENOG4105F8D glycoside hydrolase family 4 HEP87_RS20515 ENOG4105CT1 (ABC) transporter HEP87_RS20545 ENOG4108Z18 K06886 hemoglobin HEP87_RS20595 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS20600 ENOG4107ZF2 Phosphatase HEP87_RS20605 ENOG4108QV3 biosynthesis protein HEP87_RS20625 ENOG4105D3Q Sugar transferase HEP87_RS20750 ENOG4105VHU single-stranded DNA-binding protein HEP87_RS20810 ENOG4105S2J secreted protein HEP87_RS20850 ENOG4105C26 Dehydrogenase HEP87_RS20855 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEP87_RS20860 ENOG4105DH8 myo-inositol catabolism HEP87_RS20870 ENOG4105EDK PfkB domain protein HEP87_RS20875 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HEP87_RS20925 ENOG4105C7H Helicase, RecD TraA family HEP87_RS20940 ENOG4105C2J ABC transporter HEP87_RS20945 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEP87_RS20950 ENOG4108RVA ribokinase HEP87_RS20955 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HEP87_RS21005 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HEP87_RS21010 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HEP87_RS21015 ENOG4105D17 glycoside hydrolase, family 3 domain protein HEP87_RS21090 ENOG4105EDW glycosyl transferase, family 39 HEP87_RS21095 ENOG4108K8S endonuclease I HEP87_RS21105 ENOG4105C7K acetolactate synthase HEP87_RS21115 ENOG4105CK7 Sodium proline symporter HEP87_RS21125 ENOG4108XFF HEP87_RS21140 ENOG4105C29 acyl-CoA thioesterase HEP87_RS21165 ENOG4107QX3 carboxylase HEP87_RS21175 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HEP87_RS21180 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS21215 ENOG4105DY8 decarboxylase HEP87_RS21220 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HEP87_RS21230 ENOG4105DUU IucA IucC family protein HEP87_RS21235 ENOG4105E2D ec 3.2.1.52 HEP87_RS21255 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP87_RS21280 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HEP87_RS21300 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS21315 ENOG4105DRS transport system, permease HEP87_RS21345 ENOG4108NNZ chitinase HEP87_RS21380 ENOG4105CVJ phosphoglycerate mutase HEP87_RS21425 ENOG4105BZU Histidine kinase HEP87_RS21430 ENOG4105DEN Luciferase family HEP87_RS21445 ENOG4105C5I Dehydrogenase HEP87_RS21450 ENOG4105DV0 amidase (EC 3.5.1.4 HEP87_RS21490 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS21505 ENOG4105DFM M18 family aminopeptidase HEP87_RS21525 ENOG4105J5T Amp-dependent synthetase and ligase HEP87_RS21535 ENOG4108M1A Chitin-binding protein HEP87_RS21565 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HEP87_RS21585 ENOG4105FDP GntR family transcriptional regulator HEP87_RS21615 ENOG4105D9R oxidoreductase HEP87_RS21620 ENOG41090KN UPF0303 protein HEP87_RS21630 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HEP87_RS21650 ENOG4108U4N (sortase) family HEP87_RS21660 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HEP87_RS21725 ENOG4107Y2X deaminase HEP87_RS21760 ENOG41067TZ transcriptional regulator, MarR family HEP87_RS21785 ENOG4107QNK )-transporter HEP87_RS21790 ENOG4106BRA Membrane HEP87_RS21805 ENOG4108IUW ABC transporter HEP87_RS21855 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HEP87_RS21865 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HEP87_RS21925 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HEP87_RS21965 ENOG4105KF0 sporulation and cell division protein, SsgA HEP87_RS21975 ENOG4107S5I aldo keto reductase HEP87_RS21980 ENOG4105CQB FAD linked oxidase domain protein HEP87_RS21990 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HEP87_RS22020 ENOG41063PX domain protein HEP87_RS22025 ENOG4105DTQ mandelate racemase muconate lactonizing HEP87_RS22045 ENOG4105CUB amino acid HEP87_RS22095 ENOG4105E2D ec 3.2.1.52 HEP87_RS22110 ENOG4107T3P ABC, transporter HEP87_RS22120 ENOG4108UJU UPF0301 protein HEP87_RS22125 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HEP87_RS22130 ENOG4108426 dNA-binding protein HEP87_RS22140 ENOG4105EEM helicase HEP87_RS22170 ENOG4105DQQ Major facilitator superfamily MFS_1 HEP87_RS22200 ENOG4105EMY transcriptional regulator HEP87_RS22225 ENOG4105CJQ hydrolase, family 31 HEP87_RS22235 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEP87_RS22280 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HEP87_RS22285 ENOG4105CN1 protease HEP87_RS22295 ENOG4105CAK Cell division ATP-binding protein ftsE HEP87_RS22310 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HEP87_RS22345 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HEP87_RS22350 ENOG4107SJB teichoic acid biosynthesis HEP87_RS22355 ENOG4107SJB teichoic acid biosynthesis HEP87_RS22360 ENOG4107SJB teichoic acid biosynthesis HEP87_RS22375 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP87_RS22380 ENOG4105K56 Transcriptional regulator HEP87_RS22420 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS22445 ENOG4105EY8 ABC transporter HEP87_RS22450 ENOG4105CG5 Glycosyl transferase (Group 1 HEP87_RS22455 ENOG4107SJB teichoic acid biosynthesis HEP87_RS22465 ENOG4105C7I Dehydrogenase HEP87_RS22490 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HEP87_RS22500 ENOG4105T0Z Conserved Protein HEP87_RS22505 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS22510 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HEP87_RS22520 ENOG4105G3P Lipoprotein lpqB HEP87_RS22525 ENOG4105BZU Histidine kinase HEP87_RS22530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS22535 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HEP87_RS22550 ENOG4108WQ6 secreted protein HEP87_RS22555 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HEP87_RS22595 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HEP87_RS22605 ENOG4105EIP mannose-6-phosphate isomerase HEP87_RS22615 ENOG4105W49 UPF0434 protein HEP87_RS22620 ENOG4107QKV phosphomannomutase HEP87_RS22625 ENOG4105DAA L-lactate HEP87_RS22650 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP87_RS22665 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HEP87_RS22675 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HEP87_RS22690 ENOG4108KGH TRANSCRIPTIONal HEP87_RS22710 ENOG4108KGH TRANSCRIPTIONal HEP87_RS22715 ENOG4108KGH TRANSCRIPTIONal HEP87_RS22725 ENOG4105PAD Hydrolase HEP87_RS22735 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEP87_RS22780 ENOG41065SU Two-component system sensor kinase HEP87_RS22785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS22790 ENOG4105DUX Transporter HEP87_RS22835 ENOG4108Z4X TRANSCRIPTIONal HEP87_RS22865 ENOG41082AN stage II sporulation protein HEP87_RS22870 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP87_RS22880 ENOG4105CI2 imidazolone-5-propionate hydrolase HEP87_RS22895 ENOG4105CGP Urocanate hydratase HEP87_RS22935 ENOG4105C84 Histidine ammonia-lyase HEP87_RS22940 ENOG4108IJ8 ABC transporter HEP87_RS22945 ENOG4105E90 ABC transporter HEP87_RS22950 ENOG4105E90 ABC transporter HEP87_RS22960 ENOG41060NJ transcriptional regulator HEP87_RS22995 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS23030 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP87_RS23035 ENOG4107RBB ABC transporter, permease HEP87_RS23040 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HEP87_RS23045 ENOG4105CEP NADH dehydrogenase HEP87_RS23060 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HEP87_RS23075 ENOG4106A3M Cytochrome p-450 HEP87_RS23140 ENOG4105XYF acetyltransferase HEP87_RS23165 ENOG4105WFK nuclease HEP87_RS23185 ENOG4105EJ2 Transcriptional regulator HEP87_RS23200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP87_RS23205 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP87_RS23210 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP87_RS23220 ENOG4107QN1 sodium solute HEP87_RS23250 ENOG4108ZGX Histidine kinase HEP87_RS23265 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HEP87_RS23270 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HEP87_RS23275 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HEP87_RS23280 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HEP87_RS23290 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HEP87_RS23300 ENOG41067SE Tetr family transcriptional regulator HEP87_RS23310 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HEP87_RS23315 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEP87_RS23320 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS23330 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HEP87_RS23375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HEP87_RS23395 ENOG4105C5H ABC transporter HEP87_RS23405 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HEP87_RS23420 ENOG4105F8V Hydrolase, tatD family HEP87_RS23450 ENOG4107RVG penicillin-binding protein HEP87_RS23460 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HEP87_RS23505 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HEP87_RS23515 ENOG4108JJB ABC transporter HEP87_RS23520 ENOG4105K56 Transcriptional regulator HEP87_RS23525 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP87_RS23540 ENOG4105EYF MMPL domain protein HEP87_RS23560 ENOG4108R85 Short chain dehydrogenase HEP87_RS23565 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP87_RS23570 ENOG4105F95 Monooxygenase HEP87_RS23580 ENOG4105CGK Exodeoxyribonuclease III HEP87_RS23600 ENOG4108Z9I -acetyltransferase HEP87_RS23605 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP87_RS23610 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP87_RS23620 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HEP87_RS23625 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HEP87_RS23650 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HEP87_RS23660 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HEP87_RS23680 ENOG4105FF0 ErfK YbiS YcfS YnhG HEP87_RS23695 ENOG4105DM4 PTS System HEP87_RS23700 ENOG4105DE4 1-phosphofructokinase HEP87_RS23705 ENOG4105E98 transcriptional regulator DeoR family HEP87_RS23755 ENOG4108Z7F N-acetyltransferase HEP87_RS23760 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HEP87_RS23785 ENOG4107HP6 Transcriptional regulator HEP87_RS23790 ENOG4105C57 major facilitator superfamily HEP87_RS23815 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEP87_RS23830 ENOG4107ZVI PhiRv2 prophage protein HEP87_RS23885 ENOG4105CVR type I restriction-modification system HEP87_RS24110 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS24115 ENOG4105BZU Histidine kinase HEP87_RS24180 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS24235 ENOG4108ZJ4 polysaccharide deacetylase HEP87_RS24245 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HEP87_RS24290 ENOG4105J7D transcriptional regulator HEP87_RS24350 ENOG4108V06 Glutathione peroxidase HEP87_RS24365 ENOG4105DZ1 carboxypeptidase HEP87_RS24420 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HEP87_RS24440 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEP87_RS24445 ENOG41088PD hydrolase HEP87_RS24505 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS24535 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HEP87_RS24580 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HEP87_RS24585 ENOG4107RSM transcriptional regulator HEP87_RS24630 ENOG4105CGU Enoyl-CoA hydratase HEP87_RS24640 ENOG4105MXW flavin reductase domain protein, FMN-binding HEP87_RS24645 ENOG4105D2S major facilitator superfamily HEP87_RS24660 ENOG4105CC9 acyl-Coa dehydrogenase HEP87_RS24680 ENOG4105D2B acyl-CoA dehydrogenase HEP87_RS24685 ENOG4105CC9 acyl-Coa dehydrogenase HEP87_RS24695 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS24700 ENOG4107EG8 signal transduction protein with EFhand domain HEP87_RS24705 ENOG41082AN stage II sporulation protein HEP87_RS24710 ENOG4105K6V RNA polymerase HEP87_RS24760 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP87_RS24770 ENOG4108SU4 UPF0309 protein HEP87_RS24795 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HEP87_RS24805 ENOG4105CGU Enoyl-CoA hydratase HEP87_RS24810 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS24825 ENOG4107QX3 carboxylase HEP87_RS24890 ENOG4105BZ1 (ABC) transporter HEP87_RS24895 ENOG4105CQB FAD linked oxidase domain protein HEP87_RS24920 ENOG4106A3M Cytochrome p-450 HEP87_RS24930 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HEP87_RS24935 ENOG4106R7G Glycoside hydrolase family 5 HEP87_RS24960 ENOG4105CPC Aldo Keto reductase HEP87_RS24980 ENOG4105XMC MarR family Transcriptional regulator HEP87_RS24990 ENOG4105C7N Xanthine uracil vitamin C permease HEP87_RS25000 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEP87_RS25025 ENOG4108N0W Major Facilitator superfamily HEP87_RS25035 ENOG4108UIH futalosine nucleosidase HEP87_RS25040 ENOG4105E63 Pfam:DUF178 HEP87_RS25045 ENOG4105VEQ Cold shock protein HEP87_RS25070 ENOG4105CFI type iii restriction protein res subunit HEP87_RS25085 ENOG4105EEM helicase HEP87_RS25090 ENOG4106N3A copper homeostasis protein cutc HEP87_RS25125 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HEP87_RS25130 ENOG4105C5Y PTS System HEP87_RS25195 ENOG4105EBR Carboxylesterase HEP87_RS25205 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HEP87_RS25225 ENOG4105C3Q Glycosyl transferase, family 2 HEP87_RS25250 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HEP87_RS25255 ENOG4105CE4 GlcNAc 6-P deacetylase HEP87_RS25270 ENOG4105BZU Histidine kinase HEP87_RS25290 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HEP87_RS25315 ENOG4105CD8 aminopeptidase N HEP87_RS25430 ENOG4105C2N RNA methyltransferase TrmH family group 3 HEP87_RS25435 ENOG4105C8N cysteinyl-tRNA synthetase HEP87_RS25440 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HEP87_RS25445 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HEP87_RS25450 ENOG4108VJ1 Transcriptional regulator (CarD family HEP87_RS25470 ENOG4105BZU Histidine kinase HEP87_RS25500 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEP87_RS25530 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP87_RS25555 ENOG4105QNJ serralysin (EC 3.4.24.40) HEP87_RS25560 ENOG4108YZJ Pfam:DUF2596 HEP87_RS25565 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HEP87_RS25620 ENOG4105ECP epimerase HEP87_RS25625 ENOG4108KPJ rna polymerase sigma factor HEP87_RS25645 ENOG4105CPQ Dehydrogenase HEP87_RS25690 ENOG4105HHS UPF0256 protein HEP87_RS25705 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HEP87_RS25710 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HEP87_RS25715 ENOG41090R7 Ferric uptake HEP87_RS25720 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HEP87_RS25750 ENOG4105PKJ carbohydrate binding HEP87_RS25755 ENOG4105KHC sulfurtransferase HEP87_RS25780 ENOG4107NHD transcriptional regulator HEP87_RS25785 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS25790 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP87_RS25795 ENOG4105C0H protease HEP87_RS25850 ENOG4105ETX regulatoR HEP87_RS25855 ENOG4105BZ1 (ABC) transporter HEP87_RS25865 ENOG4105CGH 5'-nucleotidase HEP87_RS25870 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HEP87_RS25885 ENOG4105CJ1 ABC, transporter HEP87_RS25910 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HEP87_RS25915 ENOG4105CZV ABC transporter HEP87_RS25930 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HEP87_RS25960 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HEP87_RS25965 ENOG4105CJ3 phosphate transporter HEP87_RS25975 ENOG4105VPX protein, conserved in bacteria HEP87_RS25995 ENOG4105DNP FAD linked oxidase domain protein HEP87_RS26000 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEP87_RS26005 ENOG4105E4C Lytic transglycosylase catalytic HEP87_RS26120 ENOG4105ESP cell wall surface anchor family protein HEP87_RS26145 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HEP87_RS26155 ENOG4105CPC Aldo Keto reductase HEP87_RS26185 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HEP87_RS26205 ENOG4105C1J atp-dependent rna helicase HEP87_RS26245 ENOG4105CQ7 ATP-dependent helicase HEP87_RS26265 ENOG4108TAC HEP87_RS26305 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HEP87_RS26310 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HEP87_RS26315 ENOG410839H phosphoribosylformylglycinamidine synthase HEP87_RS26345 ENOG4105BZU Histidine kinase HEP87_RS26360 ENOG4105C8V SAICAR synthetase HEP87_RS26375 ENOG4105C12 Phosphoribosylglycinamide synthetase HEP87_RS26445 ENOG4105I6B RNA polymerase HEP87_RS26495 ENOG4105D7A ATP-binding protein HEP87_RS26510 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HEP87_RS26525 ENOG4108Z6B deaminase HEP87_RS26540 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HEP87_RS26545 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP87_RS26550 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP87_RS26565 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEP87_RS26570 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP87_RS26580 ENOG410905P Pyridoxamine 5-phosphate HEP87_RS26590 ENOG4105C57 major facilitator superfamily HEP87_RS26595 ENOG4105EDW glycosyl transferase, family 39 HEP87_RS26605 ENOG4105BZU Histidine kinase HEP87_RS26610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS26720 ENOG4105VTR Integrase HEP87_RS26925 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS26930 ENOG4105NAF rna polymerase sigma factor HEP87_RS26955 ENOG4105X7H acyl-CoA dehydrogenase HEP87_RS27030 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HEP87_RS27050 ENOG4107T6F Xaa-Pro aminopeptidase HEP87_RS27065 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HEP87_RS27125 ENOG4105DBE peroxidase HEP87_RS27130 ENOG4105CQC Prephenate dehydratase HEP87_RS27135 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HEP87_RS27140 ENOG410667J hydrolase HEP87_RS27170 ENOG4105DA5 (ABC) transporter HEP87_RS27180 ENOG4107SWG transcriptional regulator MERR family HEP87_RS27185 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HEP87_RS27195 ENOG410667J hydrolase HEP87_RS27210 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEP87_RS27215 ENOG4105C4M (Ubiquinol oxidase) subunit I HEP87_RS27220 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP87_RS27225 ENOG4107P2S Transcriptional regulator HEP87_RS27230 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HEP87_RS27245 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HEP87_RS27270 ENOG4106048 Cupin 2, conserved barrel domain protein HEP87_RS27275 ENOG41082T9 Membrane HEP87_RS27280 ENOG4105KJF protein tyrosine phosphatase HEP87_RS27285 ENOG4105C28 cystathionine HEP87_RS27320 ENOG4105F27 Major Facilitator HEP87_RS27325 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HEP87_RS27340 ENOG4105CDU Replicative dna helicase HEP87_RS27350 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HEP87_RS27355 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEP87_RS27360 ENOG4107YH6 single-stranded DNA-binding protein HEP87_RS27365 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HEP87_RS27390 ENOG4108JQC penicillin-binding protein 1A HEP87_RS27400 ENOG4105CZA synthase HEP87_RS27415 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HEP87_RS27430 ENOG4105D9P serine threonine protein kinase HEP87_RS27445 ENOG4105C3M thioredoxin reductase HEP87_RS27450 ENOG4105K63 Thioredoxin HEP87_RS27465 ENOG4107QJE Chromosome Partitioning Protein HEP87_RS27470 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HEP87_RS27480 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HEP87_RS27485 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HEP87_RS27490 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HEP87_RS27500 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HEP87_RS27505 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HEP87_RS27510 ENOG4108J5G 6-phosphogluconate dehydrogenase HEP87_RS27515 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HEP87_RS27520 ENOG4105K7N UPF0232 protein HEP87_RS27525 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP87_RS27530 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP87_RS27590 ENOG4105ZJT Cell division protein CrgA HEP87_RS27600 ENOG4108U4N (sortase) family HEP87_RS27615 ENOG4108U4N (sortase) family HEP87_RS27620 ENOG4108RN7 integral membrane protein HEP87_RS27635 ENOG4105CJN penicillin-binding protein HEP87_RS27650 ENOG4105HZM Fha domain containing protein HEP87_RS27655 ENOG4105TV9 FHA Domain-Containing protein HEP87_RS27680 ENOG41064MX Tetr family transcriptional regulator HEP87_RS27685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS27700 ENOG4108JIK carboxylase HEP87_RS27715 ENOG4105CZS beta-ketoacyl synthase HEP87_RS27760 ENOG4105D8K carboxyl transferase HEP87_RS27800 ENOG4105KVH Transcriptional regulator HEP87_RS27805 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP87_RS27825 ENOG4105DNP FAD linked oxidase domain protein HEP87_RS27845 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HEP87_RS27885 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HEP87_RS27895 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP87_RS27900 ENOG4108IG5 Transcriptional regulator HEP87_RS27920 ENOG4107QSN dihydrolipoamide acetyltransferase HEP87_RS27925 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HEP87_RS27965 ENOG4107QPV Serine Threonine protein kinase HEP87_RS27995 ENOG4105CPP Dehydrogenase, E1 component HEP87_RS28000 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HEP87_RS28065 ENOG4105DFM M18 family aminopeptidase HEP87_RS28070 ENOG4105CSU acyl-Coa dehydrogenase HEP87_RS28080 ENOG4105EUB pirin domain protein HEP87_RS28095 ENOG4105C9M aspartyl-trna synthetase HEP87_RS28125 ENOG4108J20 pectate lyase HEP87_RS28135 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HEP87_RS28150 ENOG4108KXM LysR family Transcriptional regulator HEP87_RS28170 ENOG4105F2Z 3-oxoadipate enol-lactonase HEP87_RS28175 ENOG4107SQD Transcriptional regulator, GntR family HEP87_RS28210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS28235 ENOG4105CH2 amidohydrolase HEP87_RS28255 ENOG4105EUZ Beta-lactamase domain protein HEP87_RS28265 ENOG4105BZ4 penicillin-binding protein HEP87_RS28295 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEP87_RS28305 ENOG4105VEQ Cold shock protein HEP87_RS28345 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HEP87_RS28395 ENOG4105D9P serine threonine protein kinase HEP87_RS28405 ENOG4105CK2 sodium dicarboxylate symporter HEP87_RS28415 ENOG4105JVQ RNA Polymerase HEP87_RS28430 ENOG4108HCJ Hydrolase HEP87_RS28475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS28480 ENOG4105BZU Histidine kinase HEP87_RS28490 ENOG4105EYF MMPL domain protein HEP87_RS28495 ENOG4105BZU Histidine kinase HEP87_RS28500 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS28530 ENOG41082SX arsR family transcriptional regulator HEP87_RS28535 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEP87_RS28545 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEP87_RS28605 ENOG4105ECR NmrA family HEP87_RS28630 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HEP87_RS28640 ENOG4105CSR polyphosphate kinase 2 HEP87_RS28645 ENOG4105BZP glycoside hydrolase 15-related HEP87_RS28655 ENOG4107TTQ Alpha beta hydrolase fold HEP87_RS28715 ENOG4105BZ4 penicillin-binding protein HEP87_RS28720 ENOG4108JQC penicillin-binding protein 1A HEP87_RS28740 ENOG41083YR Protein CrcB homolog HEP87_RS28745 ENOG4105KJJ Uncharacterized ACR, COG1993 HEP87_RS28750 ENOG41083TI Protein CrcB homolog HEP87_RS28765 ENOG4106F60 Histidine kinase HEP87_RS28770 ENOG4105ETX regulatoR HEP87_RS28835 ENOG4105DHP deoxycytidine triphosphate deaminase HEP87_RS28880 ENOG4105DF6 Fe-S oxidoreductase HEP87_RS28890 ENOG4105CFG Acts as a chaperone (By similarity) HEP87_RS28895 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HEP87_RS28900 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HEP87_RS28905 ENOG4105KNI merR family transcriptional Regulator HEP87_RS28910 ENOG4105CYP glycoside hydrolase, family HEP87_RS28930 ENOG4105DFW ABC transporter HEP87_RS29010 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEP87_RS29030 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS29040 ENOG4105VMP Transcriptional regulator HEP87_RS29060 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP87_RS29075 ENOG4105VTW prevent-host-death family HEP87_RS29095 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HEP87_RS29110 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HEP87_RS29115 ENOG4107RCW fructose-bisphosphate aldolase HEP87_RS29135 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HEP87_RS29160 ENOG4108ZGX Histidine kinase HEP87_RS29165 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS29185 ENOG4105DIM ABC transporter HEP87_RS29190 ENOG4105CIG ABC transporter HEP87_RS29205 ENOG4105CPD ethanolamine ammonia-lyase HEP87_RS29210 ENOG4107FQ9 ethanolamine ammonia-lyase HEP87_RS29220 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HEP87_RS29265 ENOG4105CGH 5'-nucleotidase HEP87_RS29280 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEP87_RS29285 ENOG4108V4B ThiJ pfpI HEP87_RS29300 ENOG4105CVA phosphate HEP87_RS29310 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HEP87_RS29315 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HEP87_RS29360 ENOG4105CFH Aspartokinase HEP87_RS29430 ENOG4105CRK lysyL-tRNA synthetase HEP87_RS29440 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS29440 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS29445 ENOG4105WQT MbtH domain protein HEP87_RS29450 ENOG4105E2B Taurine dioxygenase HEP87_RS29455 ENOG4105CHR reductase HEP87_RS29460 ENOG4105EV8 ectoine hydroxylase HEP87_RS29520 ENOG4108JQC penicillin-binding protein 1A HEP87_RS29560 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HEP87_RS29575 ENOG4105P8F nudix hydrolase HEP87_RS29590 ENOG4105D74 hydrolase HEP87_RS29600 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HEP87_RS29605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP87_RS29610 ENOG4105CHH sulfate transporter HEP87_RS29650 ENOG4108C33 Resolvase HEP87_RS29700 ENOG4108I5C dEAD DEAH box helicase HEP87_RS29705 ENOG4105WN5 stage II sporulation protein HEP87_RS29710 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HEP87_RS29715 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HEP87_RS29740 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEP87_RS29745 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HEP87_RS29750 ENOG4105C6E dna polymerase iii HEP87_RS29815 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS29820 ENOG4105BZU Histidine kinase HEP87_RS29840 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS29845 ENOG4105ENE Histidine kinase HEP87_RS29860 ENOG4105WQT MbtH domain protein HEP87_RS29870 ENOG4106IBS oxygenase HEP87_RS29965 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HEP87_RS29970 ENOG4105KDC 50s ribosomal protein l28 HEP87_RS29975 ENOG4105W0E 50S ribosomal protein L33 HEP87_RS29980 ENOG4105NRA 50s ribosomal protein l31 type b HEP87_RS29995 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEP87_RS30015 ENOG4105C26 Dehydrogenase HEP87_RS30030 ENOG4105CVK Glutamate decarboxylase HEP87_RS30040 ENOG4107TXC Transcriptional regulator HEP87_RS30045 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HEP87_RS30055 ENOG4105F0N pyrophosphate phospho-hydrolase HEP87_RS30070 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HEP87_RS30075 ENOG4108UGV hypoxanthine phosphoribosyltransferase HEP87_RS30085 ENOG4105EUJ GTP cyclohydrolase i HEP87_RS30095 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HEP87_RS30115 ENOG4105CRK lysyL-tRNA synthetase HEP87_RS30140 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP87_RS30155 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS30160 ENOG4105I1F Resistance protein HEP87_RS30185 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HEP87_RS30190 ENOG4108IYU L-aspartate oxidase HEP87_RS30200 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HEP87_RS30255 ENOG4105DR5 peptidase HEP87_RS30260 ENOG4108IG5 Transcriptional regulator HEP87_RS30270 ENOG4108FKE two-component system sensor kinase HEP87_RS30275 ENOG4108PYU two-component system response regulator HEP87_RS30280 ENOG41075QH Lipoprotein CseA HEP87_RS30285 ENOG4105NAF rna polymerase sigma factor HEP87_RS30300 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HEP87_RS30320 ENOG4108JWX HEP87_RS30325 ENOG4107R33 ppx gppa phosphatase HEP87_RS30330 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HEP87_RS30335 ENOG4105XEA Tetr family transcriptional regulator HEP87_RS30340 ENOG4105C01 Dihydroxy-acid dehydratase HEP87_RS30345 ENOG4108762 serine threonine protein kinase HEP87_RS30370 ENOG4105CJ1 ABC, transporter HEP87_RS30380 ENOG4105II7 pyrroline-5-carboxylate reductase HEP87_RS30385 ENOG4105C31 Tryptophanyl-tRNA synthetase HEP87_RS30420 ENOG4105DGU Histone deacetylase HEP87_RS30425 ENOG4108XFF HEP87_RS30470 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HEP87_RS30480 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HEP87_RS30485 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HEP87_RS30490 ENOG4105D52 delta-aminolevulinic acid dehydratase HEP87_RS30510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP87_RS30525 ENOG4105C75 arginyL-tRNA synthetase HEP87_RS30550 ENOG4105E0Y RtcB Protein HEP87_RS30575 ENOG4105KK4 UPF0060 membrane protein HEP87_RS30590 ENOG4105KVH Transcriptional regulator HEP87_RS30615 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP87_RS30620 ENOG4108UZX fmn reductase HEP87_RS30630 ENOG41062D9 Histidine kinase HEP87_RS30645 ENOG4105C0X amino acid HEP87_RS30650 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS30660 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP87_RS30665 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP87_RS30695 ENOG4105D0M Protease HtpX homolog HEP87_RS30705 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HEP87_RS30715 ENOG4108ZJ4 polysaccharide deacetylase HEP87_RS30730 ENOG4105C0X amino acid HEP87_RS30740 ENOG4105D7N magnesium and cobalt transport protein CorA HEP87_RS30750 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HEP87_RS30755 ENOG4108RH7 phosphoglycerate mutase HEP87_RS30775 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HEP87_RS30780 ENOG4105CRE cytochrome C HEP87_RS30830 ENOG4105YVS arsR family transcriptional regulator HEP87_RS30850 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEP87_RS30855 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HEP87_RS30860 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEP87_RS30870 ENOG4105DVY radical SAM domain protein HEP87_RS30915 ENOG4105VEQ Cold shock protein HEP87_RS30920 ENOG4105EV6 Pfam:DUF178 HEP87_RS30935 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HEP87_RS30965 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP87_RS30975 ENOG4105KNA -acetyltransferase HEP87_RS30985 ENOG41068JE domain protein HEP87_RS30995 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP87_RS31000 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEP87_RS31005 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP87_RS31015 ENOG4107QIZ NADH dehydrogenase HEP87_RS31020 ENOG4108IEH NADH dehydrogenase subunit g HEP87_RS31025 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HEP87_RS31030 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP87_RS31035 ENOG4105DF2 NADH dehydrogenase subunit j HEP87_RS31040 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP87_RS31045 ENOG4105D65 subunit l HEP87_RS31055 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP87_RS31065 ENOG4105C9U ATP-dependent DNA helicase RecQ HEP87_RS31075 ENOG4108IY8 ABC, transporter HEP87_RS31095 ENOG4105FDP GntR family transcriptional regulator HEP87_RS31110 ENOG4105CAY ferredoxin--nadp reductase HEP87_RS31120 ENOG4108FKH Transglycosylase SLT domain HEP87_RS31150 ENOG4105CJ1 ABC, transporter HEP87_RS31160 ENOG4108WS4 fmn reductase HEP87_RS31190 ENOG4105ECR NmrA family HEP87_RS31195 ENOG4105KVH Transcriptional regulator HEP87_RS31200 ENOG4105DQU oxidoreductase, subunit beta HEP87_RS31205 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HEP87_RS31225 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEP87_RS31230 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP87_RS31240 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HEP87_RS31250 ENOG4107YX3 NADH dehydrogenase subunit j HEP87_RS31255 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP87_RS31260 ENOG4105D65 subunit l HEP87_RS31265 ENOG4105C8S subunit m HEP87_RS31270 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP87_RS31275 ENOG4105D0M Protease HtpX homolog HEP87_RS31280 ENOG410901E Membrane HEP87_RS31300 ENOG4105Y3U Transglycosylase-associated protein HEP87_RS31305 ENOG4108VPT UPF0234 protein HEP87_RS31325 ENOG4105D17 glycoside hydrolase, family 3 domain protein HEP87_RS31350 ENOG4105DZC cytosine deaminase HEP87_RS31365 ENOG4105WDJ 50S ribosomal protein L33 HEP87_RS31370 ENOG410900P UPF0336 protein HEP87_RS31390 ENOG4107R4N Cell wall formation (By similarity) HEP87_RS31395 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HEP87_RS31410 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP87_RS31430 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HEP87_RS31435 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HEP87_RS31440 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HEP87_RS31450 ENOG4105QCJ Lipoprotein HEP87_RS31455 ENOG4108VZM 50s ribosomal protein L10 HEP87_RS31460 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEP87_RS31470 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP87_RS31475 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP87_RS31505 ENOG4107V6Q Cyclic nucleotide-binding domain HEP87_RS31510 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HEP87_RS31515 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HEP87_RS31520 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HEP87_RS31525 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEP87_RS31545 ENOG4106A3M Cytochrome p-450 HEP87_RS31590 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP87_RS31645 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HEP87_RS31655 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HEP87_RS31660 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HEP87_RS31665 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HEP87_RS31670 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HEP87_RS31675 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HEP87_RS31680 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HEP87_RS31685 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HEP87_RS31690 ENOG41082SA 50s ribosomal protein l29 HEP87_RS31695 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HEP87_RS31700 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HEP87_RS31705 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HEP87_RS31710 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HEP87_RS31715 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HEP87_RS31725 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HEP87_RS31730 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HEP87_RS31735 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HEP87_RS31740 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HEP87_RS31745 ENOG410849U 50S ribosomal protein L30 HEP87_RS31750 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HEP87_RS31760 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HEP87_RS31780 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HEP87_RS31785 ENOG41067V7 50S ribosomal protein L36 HEP87_RS31790 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HEP87_RS31795 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HEP87_RS31800 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP87_RS31805 ENOG4108ZT0 50S ribosomal protein l17 HEP87_RS31810 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HEP87_RS31830 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEP87_RS31835 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HEP87_RS31845 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HEP87_RS31850 ENOG4108UJD 30S ribosomal protein S9 HEP87_RS31855 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HEP87_RS31865 ENOG4105CS9 pantothenic acid kinase HEP87_RS31870 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP87_RS31925 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HEP87_RS31930 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HEP87_RS31935 ENOG4108097 ATP-binding protein HEP87_RS31960 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HEP87_RS31970 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS31995 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS32030 ENOG4105CHP RNA polymerase HEP87_RS32050 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HEP87_RS32055 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HEP87_RS32065 ENOG4105EMU Dehydrogenase HEP87_RS32075 ENOG4105DND Transcriptional regulator HEP87_RS32080 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP87_RS32090 ENOG4108MMM RNA Polymerase HEP87_RS32100 ENOG4107QVP Dehydrogenase HEP87_RS32110 ENOG4107QQG Dehydrogenase HEP87_RS32115 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HEP87_RS32135 ENOG4107TPY serine threonine protein kinase HEP87_RS32145 ENOG4107TPY serine threonine protein kinase HEP87_RS32160 ENOG4105C26 Dehydrogenase HEP87_RS32185 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HEP87_RS32230 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS32295 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HEP87_RS32305 ENOG4105DEG Vwa containing coxe family protein HEP87_RS32320 ENOG4105CMV Succinyl-CoA synthetase subunit beta HEP87_RS32350 ENOG4105DC1 bifunctional purine biosynthesis protein purh HEP87_RS32370 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HEP87_RS32390 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HEP87_RS32425 ENOG4108IJ7 Glycine betaine HEP87_RS32430 ENOG4108HQS Glycine betaine HEP87_RS32445 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP87_RS32450 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP87_RS32460 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP87_RS32480 ENOG4108ES0 acetoacetyl-CoA synthetase HEP87_RS32490 ENOG4108ZFD Antibiotic biosynthesis monooxygenase HEP87_RS32515 ENOG4106032 Glutathionylspermidine synthase HEP87_RS32520 ENOG4105C8Y Acetylornithine aminotransferase HEP87_RS32525 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP87_RS32535 ENOG4105C31 Tryptophanyl-tRNA synthetase HEP87_RS32570 ENOG4107H3J ribonuclease HEP87_RS32585 ENOG4107RN3 metallophosphoesterase HEP87_RS32590 ENOG4108EVY peptide transport periplasmic protein HEP87_RS32605 ENOG4105BZU Histidine kinase HEP87_RS32610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS32615 ENOG4105EYF MMPL domain protein HEP87_RS32625 ENOG4105U5Y Transcriptional regulator HEP87_RS32670 ENOG4108J01 L-aspartate oxidase HEP87_RS32720 ENOG4108MMM RNA Polymerase HEP87_RS32725 ENOG4108MMM RNA Polymerase HEP87_RS32750 ENOG4108NIW Leucine export protein LeuE HEP87_RS32775 ENOG4105K64 Glycosyl transferase, family 2 HEP87_RS32785 ENOG4105F0R Cytidylyltransferase HEP87_RS32790 ENOG4105D2T synthase HEP87_RS32800 ENOG4105C8U phosphate abc transporter HEP87_RS32825 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HEP87_RS32830 ENOG4105K7W phage-related replication protein HEP87_RS32895 ENOG4107RM1 amidohydrolase HEP87_RS32900 ENOG4105DIH basic membrane HEP87_RS32905 ENOG4105DIH basic membrane HEP87_RS32910 ENOG4108JQ9 ABC transporter HEP87_RS32955 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HEP87_RS32960 ENOG4105D94 Major Facilitator Superfamily HEP87_RS32965 ENOG4107RSM transcriptional regulator HEP87_RS32975 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP87_RS33000 ENOG41065SU Two-component system sensor kinase HEP87_RS33005 ENOG4108KXV response regulator HEP87_RS33010 ENOG4105NAF rna polymerase sigma factor HEP87_RS33025 ENOG4105C26 Dehydrogenase HEP87_RS33030 ENOG4105C26 Dehydrogenase HEP87_RS33050 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HEP87_RS33090 ENOG4107WR6 Maf-like protein HEP87_RS33105 ENOG4105D8K carboxyl transferase HEP87_RS33115 ENOG4108QER Adenylate cyclase HEP87_RS33130 ENOG4105E39 Enoyl-CoA hydratase HEP87_RS33135 ENOG4105KDM Diguanylate cyclase with gaf sensor HEP87_RS33140 ENOG4105C84 Histidine ammonia-lyase HEP87_RS33145 ENOG4105VEQ Cold shock protein HEP87_RS33180 ENOG4105C19 ABC transporter HEP87_RS33200 ENOG4105DQ4 alcohol dehydrogenase HEP87_RS33205 ENOG4105TVJ transport system, permease HEP87_RS33210 ENOG4105DQ5 transport system permease protein HEP87_RS33220 ENOG4107R16 Multicopper oxidase HEP87_RS33300 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HEP87_RS33325 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HEP87_RS33330 ENOG4105C7B Threonine dehydratase HEP87_RS33355 ENOG4105EW6 flavin reductase domain protein, FMN-binding HEP87_RS33360 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HEP87_RS33370 ENOG4105T1M mycothiol conjugate amidase mca HEP87_RS33395 ENOG4105C7Z Conserved Protein HEP87_RS33440 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HEP87_RS33455 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEP87_RS33470 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HEP87_RS33515 ENOG4105CHM Aminotransferase HEP87_RS33545 ENOG4108FUF Transcriptional regulator, IclR family HEP87_RS33550 ENOG4105KME endoribonuclease L-psp HEP87_RS33555 ENOG4105C6Z Gluconate HEP87_RS33605 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid HEP87_RS33645 ENOG4107QMS site-determining protein HEP87_RS33680 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS33700 ENOG4107QKZ Ompa motb domain protein HEP87_RS33705 ENOG4105NAE bifunctional deaminase-reductase domain protein HEP87_RS33720 ENOG4108Z6B deaminase HEP87_RS33740 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HEP87_RS33745 ENOG4108IAB Phoh family HEP87_RS33760 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP87_RS33765 ENOG4105D3R alkyl hydroperoxide reductase HEP87_RS33780 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP87_RS33805 ENOG4105CH6 catalase HEP87_RS33820 ENOG4105C9Q fumarate hydratase class II HEP87_RS33835 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HEP87_RS33840 ENOG4107GFK fumarate HEP87_RS33850 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP87_RS33865 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HEP87_RS33870 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEP87_RS33875 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEP87_RS33880 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HEP87_RS33895 ENOG4105C3G gtp-binding protein HEP87_RS33965 ENOG4105CHR reductase HEP87_RS34035 ENOG4105E33 succinate dehydrogenase HEP87_RS34045 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HEP87_RS34065 ENOG4105CI3 gtp-binding protein typa HEP87_RS34080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP87_RS34090 ENOG4108JQ7 (ABC) transporter HEP87_RS34095 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HEP87_RS34110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP87_RS34115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP87_RS34120 ENOG4105C3U ABC transporter HEP87_RS34125 ENOG4108JQ7 (ABC) transporter HEP87_RS34155 ENOG4108M15 ABC transporter HEP87_RS34165 ENOG4108ZGX Histidine kinase HEP87_RS34170 ENOG4108S01 response regulator HEP87_RS34185 ENOG4108Z4U Ferredoxin HEP87_RS34205 ENOG4107R4C succinyl-diaminopimelate desuccinylase HEP87_RS34210 ENOG4108URH decarboxylase HEP87_RS34215 ENOG4105EEI dihydropteroate synthase HEP87_RS34225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HEP87_RS34230 ENOG4105CGU Enoyl-CoA hydratase HEP87_RS34245 ENOG4105DU6 RNA polymerase HEP87_RS34260 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HEP87_RS34285 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HEP87_RS34295 ENOG4105D7N magnesium and cobalt transport protein CorA HEP87_RS34305 ENOG4105DXB Major Facilitator superfamily HEP87_RS34320 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HEP87_RS34335 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HEP87_RS34380 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP87_RS34385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP87_RS34430 ENOG4106JDR secreted HEP87_RS34455 ENOG4107QSE Dipeptidase HEP87_RS34550 ENOG41063PX domain protein HEP87_RS34560 ENOG4105DJZ UPF0182 protein HEP87_RS34590 ENOG4105C2X Arabinose 5-phosphate isomerase HEP87_RS34595 ENOG4107TK4 histidinol-phosphate phosphatase HEP87_RS34625 ENOG4108RAV Conserved protein HEP87_RS34635 ENOG4105EMN RNA polymerase sigma factor HEP87_RS34640 ENOG4105WMN AntiSigma factor HEP87_RS34645 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HEP87_RS34660 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HEP87_RS34670 ENOG41068W2 Cytochrome p-450 HEP87_RS34690 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEP87_RS34695 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEP87_RS34715 ENOG4105FDP GntR family transcriptional regulator HEP87_RS34740 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HEP87_RS34750 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP87_RS34765 ENOG4105CBD Diacylglycerol kinase HEP87_RS34810 ENOG4105ESN nucleotide-binding protein HEP87_RS34880 ENOG4108VEQ Superoxide dismutase HEP87_RS34900 ENOG4105CDA abc transporter atp-binding protein HEP87_RS34915 ENOG4105C6K Malic enzyme HEP87_RS34920 ENOG4105CB2 alcohol dehydrogenase HEP87_RS34955 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEP87_RS34960 ENOG4105EB3 Histidine kinase HEP87_RS34965 ENOG4108PYU two-component system response regulator HEP87_RS34970 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP87_RS35000 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HEP87_RS35050 ENOG4105ZXU NLP P60 protein HEP87_RS35060 ENOG4108IG5 Transcriptional regulator HEP87_RS35090 ENOG4105CJN penicillin-binding protein HEP87_RS35095 ENOG4107QHZ cell cycle protein HEP87_RS35130 ENOG4105FDF Could be involved in DNA repair (By similarity) HEP87_RS35135 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEP87_RS35250 ENOG4105CZE histidine utilization repressor HEP87_RS35315 ENOG4105ETX regulatoR HEP87_RS35320 ENOG4105C75 arginyL-tRNA synthetase HEP87_RS35325 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HEP87_RS35330 ENOG4105D6E homoserine dehydrogenase HEP87_RS35335 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HEP87_RS35340 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HEP87_RS35350 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP87_RS35355 ENOG4108KGH TRANSCRIPTIONal HEP87_RS35360 ENOG4105VFB Binds the 23S rRNA (By similarity) HEP87_RS35365 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HEP87_RS35370 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP87_RS35380 ENOG4107ZF2 Phosphatase HEP87_RS35385 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP87_RS35390 ENOG4105ESV Glycosyl transferase, family 4 HEP87_RS35395 ENOG4105Z3P ATP synthase HEP87_RS35405 ENOG4105ZA1 atp synthase HEP87_RS35410 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HEP87_RS35415 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HEP87_RS35420 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HEP87_RS35425 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HEP87_RS35430 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HEP87_RS35435 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HEP87_RS35450 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS35455 ENOG4105BZU Histidine kinase HEP87_RS35460 ENOG4105IIP Membrane HEP87_RS35480 ENOG410630P Transcriptional regulator HEP87_RS35485 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP87_RS35500 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HEP87_RS35545 ENOG4105CJ1 ABC, transporter HEP87_RS35565 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS35600 ENOG4105VCH membrane HEP87_RS35640 ENOG4105WX6 Membrane HEP87_RS35680 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEP87_RS35685 ENOG4105C6K Malic enzyme HEP87_RS35690 ENOG4105CTQ phosphohexokinase HEP87_RS35735 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEP87_RS35740 ENOG4105CK2 sodium dicarboxylate symporter HEP87_RS35760 ENOG4107SET aldo keto reductase HEP87_RS35795 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HEP87_RS35805 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HEP87_RS35810 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP87_RS35815 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HEP87_RS35840 ENOG4105BZ1 (ABC) transporter HEP87_RS35845 ENOG4105BZ1 (ABC) transporter HEP87_RS35850 ENOG4105BZ1 (ABC) transporter HEP87_RS35855 ENOG4105CJ1 ABC, transporter HEP87_RS35865 ENOG4105BZU Histidine kinase HEP87_RS35870 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS35880 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HEP87_RS35885 ENOG41069FZ L,D-transpeptidase catalytic domain HEP87_RS35930 ENOG4105DKW ABC transporter HEP87_RS35935 ENOG4107SNV Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HEP87_RS35975 ENOG4105EJQ L-serine dehydratase HEP87_RS35980 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP87_RS35985 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HEP87_RS35990 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HEP87_RS36010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP87_RS36030 ENOG4108JQ7 (ABC) transporter HEP87_RS36045 ENOG4105EN6 Membrane HEP87_RS36065 ENOG4105D29 Helix-turn-helix type 11 domain protein HEP87_RS36105 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HEP87_RS36115 ENOG4108URH decarboxylase HEP87_RS36120 ENOG4105EMU Dehydrogenase HEP87_RS36130 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEP87_RS36135 ENOG4105BZU Histidine kinase HEP87_RS36140 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HEP87_RS36145 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HEP87_RS36155 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HEP87_RS36160 ENOG4105EYF MMPL domain protein HEP87_RS36165 ENOG4105D9U N-acetyltransferase HEP87_RS36195 ENOG4105CPC Aldo Keto reductase HEP87_RS36215 ENOG4108ZP8 Acetolactate synthase small subunit HEP87_RS36220 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HEP87_RS36230 ENOG4107SM8 Adenylate Guanylate cyclase HEP87_RS36255 ENOG4105T0Z Conserved Protein HEP87_RS36270 ENOG4105C26 Dehydrogenase HEP87_RS36295 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP87_RS36305 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HEP87_RS36310 ENOG4105CM2 brancheD-chain amino acid aminotransferase HEP87_RS36340 ENOG4105CQM Urea amidohydrolase subunit alpha HEP87_RS36345 ENOG4105DWY Agmatine deiminase HEP87_RS36355 ENOG4105CSH Transporter HEP87_RS36360 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HEP87_RS36370 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEP87_RS36390 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS36400 ENOG4105CJ1 ABC, transporter HEP87_RS36435 ENOG4105BZU Histidine kinase HEP87_RS36440 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS36445 ENOG4108YYC ycei family HEP87_RS36450 ENOG4105D8K carboxyl transferase HEP87_RS36470 ENOG4105GWZ Roadblock lc7 family protein HEP87_RS36490 ENOG4105GWZ Roadblock lc7 family protein HEP87_RS36505 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HEP87_RS36510 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HEP87_RS36560 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HEP87_RS36565 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HEP87_RS36575 ENOG4105K70 DNA-binding protein HEP87_RS36595 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEP87_RS36600 ENOG4105CPF Cell wall formation (By similarity) HEP87_RS36630 ENOG4105VB9 50S ribosomal protein l28 HEP87_RS36635 ENOG4105DP4 dak2 domain fusion protein ylov HEP87_RS36645 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HEP87_RS36655 ENOG4106H78 methyltransferase HEP87_RS36660 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HEP87_RS36675 ENOG41084BZ 50S ribosomal protein L32 HEP87_RS36680 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HEP87_RS36685 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HEP87_RS36690 ENOG4105KVH Transcriptional regulator HEP87_RS36735 ENOG4105K4I Scp-like extracellular HEP87_RS36740 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HEP87_RS36795 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HEP87_RS36805 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HEP87_RS36815 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HEP87_RS36825 ENOG4105K5M 30s ribosomal protein S16 HEP87_RS36830 ENOG41082KU UPF0109 protein HEP87_RS36835 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HEP87_RS36840 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HEP87_RS36845 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HEP87_RS36865 ENOG4107QYR Signal peptidase i HEP87_RS36875 ENOG41080R2 UPF0102 protein HEP87_RS36890 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP87_RS36905 ENOG4105CE9 30S ribosomal protein S2 HEP87_RS36910 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HEP87_RS36915 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HEP87_RS36920 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HEP87_RS36925 ENOG4105KNE Phosphatidate cytidylyltransferase HEP87_RS36935 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HEP87_RS36945 ENOG4105ECW sulfate abc transporter HEP87_RS36950 ENOG4108UCS ABC, transporter HEP87_RS36980 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP87_RS36985 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEP87_RS36995 ENOG4105C26 Dehydrogenase HEP87_RS37060 ENOG4105EW9 transcriptional regulator AsnC family HEP87_RS37070 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP87_RS37090 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP87_RS37105 ENOG4105C26 Dehydrogenase HEP87_RS37115 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP87_RS37120 ENOG4105F38 ABC transporter, permease HEP87_RS37125 ENOG4105D38 putrescine abc transporter HEP87_RS37130 ENOG4105CJP fad dependent oxidoreductase HEP87_RS37160 ENOG4105G9B Transcriptional regulator HEP87_RS37160 ENOG4105G9B Transcriptional regulator HEP87_RS37190 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HEP87_RS37225 ENOG4107P2S Transcriptional regulator HEP87_RS37245 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HEP87_RS37260 ENOG4105DZP Membrane-associated zinc metalloprotease HEP87_RS37265 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HEP87_RS37280 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HEP87_RS37310 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HEP87_RS37325 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HEP87_RS37350 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HEP87_RS37355 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HEP87_RS37375 ENOG4105C3U ABC transporter HEP87_RS37380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP87_RS37385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP87_RS37420 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HEP87_RS37495 ENOG4105EC2 ftsk spoIIIe HEP87_RS37510 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HEP87_RS37515 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HEP87_RS37520 ENOG4105C1V Peptidase, M16 HEP87_RS37525 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HEP87_RS37550 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP87_RS37555 ENOG4105CN5 Metallo-Beta-Lactamase HEP87_RS37600 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HEP87_RS37605 ENOG4107QZI cell division protein FtsK HEP87_RS37615 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HEP87_RS37625 ENOG4105CEV competence damage-inducible protein HEP87_RS37630 ENOG4105WBV Transcriptional regulator HEP87_RS37635 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HEP87_RS37640 ENOG4105CHR reductase HEP87_RS37645 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HEP87_RS37680 ENOG4105DSF transport protein HEP87_RS37690 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HEP87_RS37735 ENOG4105DRP amino acid AbC transporter HEP87_RS37740 ENOG4108Q1T ABC transporter HEP87_RS37745 ENOG4107UBR Extracellular solute-binding protein family 3 HEP87_RS37750 ENOG4105CDA abc transporter atp-binding protein HEP87_RS37755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS37785 ENOG4105BZU Histidine kinase HEP87_RS37790 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS37855 ENOG4107TXC Transcriptional regulator HEP87_RS37870 ENOG4105KRQ Addiction module toxin, Txe YoeB family HEP87_RS37885 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HEP87_RS37905 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HEP87_RS37910 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HEP87_RS37930 ENOG41083PU Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP87_RS37965 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HEP87_RS37985 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HEP87_RS37995 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HEP87_RS38000 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEP87_RS38010 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HEP87_RS38080 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEP87_RS38085 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HEP87_RS38125 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HEP87_RS38140 ENOG4105C9U ATP-dependent DNA helicase RecQ HEP87_RS38155 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEP87_RS38160 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEP87_RS38165 ENOG4105DRR Transcriptional regulator, GntR family HEP87_RS38170 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP87_RS38175 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP87_RS38185 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP87_RS38200 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS38215 ENOG4108V9W transcriptional regulatory protein HEP87_RS38225 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HEP87_RS38235 ENOG4108MRH transcriptional regulatory protein HEP87_RS38270 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP87_RS38300 ENOG410849S phosphocarrier protein (HPr) HEP87_RS38305 ENOG4105CD5 CoA-binding domain protein HEP87_RS38320 ENOG4107W53 thymidine kinase HEP87_RS38355 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HEP87_RS38370 ENOG4105F44 Two component transcriptional regulator, winged helix family HEP87_RS38375 ENOG4106F60 Histidine kinase HEP87_RS38400 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HEP87_RS38415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP87_RS38445 ENOG4107VEG TrkA-N domain protein HEP87_RS38450 ENOG4105C0X amino acid HEP87_RS38545 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HEP87_RS38550 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEP87_RS38570 ENOG4105EQQ protein containing aminopeptidase domain HEP87_RS38585 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HEP87_RS38615 ENOG4107RRD Dehydrogenase HEP87_RS38620 ENOG4105CAQ asparagine synthetase HEP87_RS38640 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEP87_RS38645 ENOG4105D3Q Sugar transferase HEP87_RS38650 ENOG4105C7K acetolactate synthase HEP87_RS38685 ENOG4105F4R Transcriptional regulator mode HEP87_RS38690 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEP87_RS38715 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP87_RS38725 ENOG4107S1Q Phosphatase HEP87_RS38740 ENOG4105CEU Arginine dihydrolase HEP87_RS38745 ENOG4105DBV ornithine carbamoyltransferase HEP87_RS38750 ENOG4105CUB amino acid HEP87_RS38760 ENOG4105CGU Enoyl-CoA hydratase HEP87_RS38815 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HEP87_RS38830 ENOG4107QM5 aconitate hydratase HEP87_RS38840 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP87_RS38845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS38865 ENOG4105CWX Alpha-1,2-mannosidase HEP87_RS38875 ENOG4105CHR reductase HEP87_RS38900 ENOG4105E2R ROK family HEP87_RS38905 ENOG4105DFW ABC transporter HEP87_RS38910 ENOG4105C2J ABC transporter HEP87_RS38915 ENOG4108HWW ABC transporter HEP87_RS38920 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HEP87_RS38925 ENOG4105CUB amino acid HEP87_RS38945 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP87_RS38950 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS38975 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HEP87_RS38990 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HEP87_RS39005 ENOG4105C1Q protoporphyrinogen oxidase HEP87_RS39010 ENOG4107JTW chlorite dismutase HEP87_RS39080 ENOG4105C22 threonyL-tRNA synthetase HEP87_RS39095 ENOG4107B2H carbonic anhydrase HEP87_RS39120 ENOG4105DFU Cell wall formation (By similarity) HEP87_RS39125 ENOG4105E0X reductase HEP87_RS39145 ENOG4105BZU Histidine kinase HEP87_RS39190 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HEP87_RS39205 ENOG4105EDW glycosyl transferase, family 39 HEP87_RS39230 ENOG4105DHQ Histidine kinase HEP87_RS39315 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP87_RS39345 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HEP87_RS39350 ENOG4105DUM transcriptional regulator, lysR family HEP87_RS39355 ENOG4105C0H protease HEP87_RS39390 ENOG4105ZSU inhibitor HEP87_RS39490 ENOG4105MC2 DSBA oxidoreductase HEP87_RS39510 ENOG4108IY8 ABC, transporter HEP87_RS39540 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HEP87_RS39565 ENOG4107RR1 TRANSCRIPTIONal HEP87_RS39570 ENOG4105CSU acyl-Coa dehydrogenase HEP87_RS39585 ENOG4105E7U AraC family transcriptional regulator HEP87_RS39610 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS39620 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HEP87_RS39635 ENOG4105EBR Carboxylesterase HEP87_RS39650 ENOG4108J5H Homocysteine s-methyltransferase HEP87_RS39770 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HEP87_RS39780 ENOG4105GWZ Roadblock lc7 family protein HEP87_RS39815 ENOG4105CJ1 ABC, transporter HEP87_RS39830 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HEP87_RS39850 ENOG4105QE3 oxidoreductase HEP87_RS39865 ENOG4105CYP glycoside hydrolase, family HEP87_RS39960 ENOG4105ESF Peptidoglycan binding domain protein HEP87_RS40010 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HEP87_RS40020 ENOG4105EC3 peptidase S51, dipeptidase E HEP87_RS40060 ENOG4105C7K acetolactate synthase HEP87_RS40110 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HEP87_RS40115 ENOG4105C7N Xanthine uracil vitamin C permease HEP87_RS40165 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) HEP87_RS40170 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP87_RS40185 ENOG4105C0W non-ribosomal peptide synthetase HEP87_RS40200 ENOG4105CJ2 (LipO)protein HEP87_RS40215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS40220 ENOG4105BZU Histidine kinase HEP87_RS40265 ENOG4105EF1 ribulokinase HEP87_RS40290 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS40295 ENOG4105DME alpha-galactosidase HEP87_RS40310 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS40315 ENOG4105C2J ABC transporter HEP87_RS40320 ENOG4105CNN ABC, transporter HEP87_RS40325 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator HEP87_RS40350 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS40355 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HEP87_RS40405 ENOG4105CFG Acts as a chaperone (By similarity) HEP87_RS40430 ENOG4105PGM cation diffusion facilitator family transporter HEP87_RS40490 ENOG4105D7N magnesium and cobalt transport protein CorA HEP87_RS40500 ENOG410829K Lysine exporter protein (Lyse ygga) HEP87_RS40505 ENOG4107RSM transcriptional regulator HEP87_RS40515 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP87_RS40535 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS40545 ENOG41060W2 glyoxylate carboligase HEP87_RS40555 ENOG4105CH6 catalase HEP87_RS40560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEP87_RS40565 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HEP87_RS40585 ENOG4105VT2 5-hydroxyisourate hydrolase HEP87_RS40595 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP87_RS40615 ENOG4105KVH Transcriptional regulator HEP87_RS40630 ENOG4108ZM9 phosphoglycerate mutase HEP87_RS40635 ENOG4105CHM Aminotransferase HEP87_RS40660 ENOG4105DUU IucA IucC family protein HEP87_RS40690 ENOG4107R9S Malate synthase HEP87_RS40715 ENOG4107HP6 Transcriptional regulator HEP87_RS40730 ENOG4105D7N magnesium and cobalt transport protein CorA HEP87_RS40745 ENOG4105CPC Aldo Keto reductase HEP87_RS40750 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS40760 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP87_RS40780 ENOG4105CNN ABC, transporter HEP87_RS40790 ENOG4105DKQ ROK family HEP87_RS40825 ENOG4105ETX regulatoR HEP87_RS40830 ENOG4106F60 Histidine kinase HEP87_RS40835 ENOG4105DQR SNARE associated Golgi HEP87_RS40840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HEP87_RS40865 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEP87_RS40870 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HEP87_RS40895 ENOG4105CPQ Dehydrogenase HEP87_RS40915 ENOG4105E98 transcriptional regulator DeoR family HEP87_RS40940 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HEP87_RS40975 ENOG4105ECQ AraC Family Transcriptional Regulator HEP87_RS41005 ENOG4108MUZ hydrolase HEP87_RS41020 ENOG4105ETX regulatoR HEP87_RS41025 ENOG41065SU Two-component system sensor kinase HEP87_RS41160 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP87_RS41230 ENOG41082J7 Rhodanese domain protein HEP87_RS41275 ENOG4105CVK Glutamate decarboxylase HEP87_RS41320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP87_RS41335 ENOG4105E2B Taurine dioxygenase HEP87_RS41340 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP87_RS41360 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS41395 ENOG4105BZP glycoside hydrolase 15-related HEP87_RS41735 ENOG4108KPJ rna polymerase sigma factor HEP87_RS41760 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HEP87_RS41765 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS41790 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HEP87_RS41800 ENOG4105WQI isochorismatase HEP87_RS41805 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HEP87_RS41880 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HEP87_RS41885 ENOG4105E8R UPF0173 metal-dependent hydrolase HEP87_RS41900 ENOG4105CDA abc transporter atp-binding protein HEP87_RS41910 ENOG4105EAD ABC transporter HEP87_RS41915 ENOG4105DRP amino acid AbC transporter HEP87_RS41930 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HEP87_RS41960 ENOG4105C8Y Acetylornithine aminotransferase HEP87_RS41975 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HEP87_RS41985 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HEP87_RS41995 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HEP87_RS42005 ENOG4105BZU Histidine kinase HEP87_RS42010 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS42025 ENOG4108YYQ gCN5-related N-acetyltransferase HEP87_RS42040 ENOG4105DA5 (ABC) transporter HEP87_RS42065 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP87_RS42100 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP87_RS42105 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HEP87_RS42110 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP87_RS42160 ENOG4105ECY inositol monophosphatase HEP87_RS42175 ENOG4108UVJ appr-1-p processing domain protein HEP87_RS42180 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HEP87_RS42190 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HEP87_RS42195 ENOG4106NZI LysR family Transcriptional regulator HEP87_RS42205 ENOG4105CBP Major Facilitator HEP87_RS42220 ENOG41060BG Tetr family transcriptional regulator HEP87_RS42270 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEP87_RS42300 ENOG41066UM arsR family transcriptional regulator HEP87_RS42345 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HEP87_RS42350 ENOG4105C2U cobyrinic Acid a,c-diamide synthase HEP87_RS42395 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HEP87_RS42400 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS42410 ENOG4105CI0 Citrate lyase HEP87_RS42430 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP87_RS42440 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HEP87_RS42450 ENOG4106JDR secreted HEP87_RS42470 ENOG4108Q50 Histidine kinase HEP87_RS42515 ENOG4108ME1 Peptidase M55 D-aminopeptidase HEP87_RS42520 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HEP87_RS42530 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HEP87_RS42555 ENOG4105CV1 Transketolase (EC 2.2.1.1) HEP87_RS42565 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP87_RS42575 ENOG4105C5H ABC transporter HEP87_RS42665 ENOG4105CFG Acts as a chaperone (By similarity) HEP87_RS42685 ENOG4107RSM transcriptional regulator HEP87_RS42690 ENOG410842T Pterin carbinolamine dehydratase HEP87_RS42705 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP87_RS42720 ENOG4105D29 Helix-turn-helix type 11 domain protein HEP87_RS42725 ENOG4105CX8 fg-gap repeat protein HEP87_RS42735 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HEP87_RS42745 ENOG4105CYP glycoside hydrolase, family HEP87_RS42755 ENOG41065HY 1,4-beta-cellobiosidase HEP87_RS42795 ENOG4105CV8 reductase HEP87_RS42820 ENOG4105F5H Glycosyl Hydrolase Family 88 HEP87_RS42830 ENOG4106UDK Cellulose-binding, family II HEP87_RS42850 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HEP87_RS43020 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEP87_RS43130 ENOG4105DHU Bile acid HEP87_RS43145 ENOG4108478 ec 3.2.1.18 HEP87_RS43155 ENOG4108VHT MarR family transcriptional regulator HEP87_RS43160 ENOG4105D3W isochorismatase HEP87_RS43170 ENOG4106NZI LysR family Transcriptional regulator HEP87_RS43175 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HEP87_RS43190 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEP87_RS43195 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEP87_RS43205 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP87_RS43235 ENOG4105DKQ ROK family HEP87_RS43240 ENOG4105C2J ABC transporter HEP87_RS43245 ENOG4105CNN ABC, transporter HEP87_RS43250 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEP87_RS43295 ENOG4105F8V Hydrolase, tatD family HEP87_RS43320 ENOG4105FCD Major Facilitator HEP87_RS43340 ENOG4105CMV Succinyl-CoA synthetase subunit beta HEP87_RS43465 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP87_RS43475 ENOG4108MIC Mg-protoporphyrin IX methyl transferase HEP87_RS43495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP87_RS43510 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HEP87_RS43520 ENOG4105EMU Dehydrogenase HEP87_RS43540 ENOG4105NRA 50s ribosomal protein l31 type b HEP87_RS43560 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS43575 ENOG4108RZE Tetr family transcriptional regulator HEP87_RS43615 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP87_RS43620 ENOG4105CHR reductase HEP87_RS43630 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEP87_RS43645 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP87_RS43665 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS43680 ENOG4108M9J MaoC like domain protein HEP87_RS43695 ENOG4105CPQ Dehydrogenase HEP87_RS43705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS43720 ENOG4106A3M Cytochrome p-450 HEP87_RS43770 ENOG4108YYC ycei family HEP87_RS43780 ENOG4105DRP amino acid AbC transporter HEP87_RS43785 ENOG4105CDA abc transporter atp-binding protein HEP87_RS43810 ENOG4105DEN Luciferase family HEP87_RS43815 ENOG4105DEN Luciferase family HEP87_RS43845 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP87_RS43855 ENOG41060NJ transcriptional regulator HEP87_RS43865 ENOG4108NNI Beta-lactamase domain-containing protein HEP87_RS43870 ENOG4108RZE Tetr family transcriptional regulator HEP87_RS43915 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEP87_RS43930 ENOG4105C84 Histidine ammonia-lyase HEP87_RS44010 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP87_RS44050 ENOG4107QJN gtp cyclohydrolase ii HEP87_RS44090 ENOG410905P Pyridoxamine 5-phosphate HEP87_RS44105 ENOG4105CSH Transporter HEP87_RS44135 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP87_RS44140 ENOG4108J5G 6-phosphogluconate dehydrogenase HEP87_RS44145 ENOG4107QP8 phosphohexose isomerase HEP87_RS44160 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEP87_RS44195 ENOG4105CHR reductase HEP87_RS44245 ENOG4108MGF sugar kinase HEP87_RS44250 ENOG4105E98 transcriptional regulator DeoR family HEP87_RS44255 ENOG4105F8D glycoside hydrolase family 4 HEP87_RS44265 ENOG4106UDK Cellulose-binding, family II HEP87_RS44330 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP87_RS44335 ENOG4107TYH extracellular solute-binding protein family 1 HEP87_RS44340 ENOG4105D81 ABC transporter, permease HEP87_RS44345 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HEP87_RS44370 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP87_RS44375 ENOG4105CTU Proline racemase HEP87_RS44395 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP87_RS44400 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HEP87_RS44405 ENOG4105CG3 alpha amylase, catalytic region HEP87_RS44415 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP87_RS44420 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP87_RS44535 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HEP87_RS44540 ENOG4105CSH Transporter HEP87_RS44550 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HEP87_RS44570 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS44585 ENOG41067TZ transcriptional regulator, MarR family HEP87_RS44595 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HEP87_RS44615 ENOG4105DQE DNA ligase HEP87_RS44620 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS44635 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP87_RS44675 ENOG4106V2I dimethylaminohydrolase HEP87_RS44680 ENOG4105C5H ABC transporter HEP87_RS44695 ENOG4105KF0 sporulation and cell division protein, SsgA HEP87_RS44720 ENOG4105EG6 Saccharopine dehydrogenase HEP87_RS44725 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP87_RS44730 ENOG4105DYW oxidoreductase HEP87_RS44735 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS44740 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS44745 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP87_RS44790 ENOG4105C5H ABC transporter HEP87_RS44800 ENOG4105BZM domain protein HEP87_RS44810 ENOG4105ECQ AraC Family Transcriptional Regulator HEP87_RS44820 ENOG4105E39 Enoyl-CoA hydratase HEP87_RS44835 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HEP87_RS44865 ENOG4108MDK Dehydrogenase HEP87_RS44885 ENOG4105EY8 ABC transporter HEP87_RS44890 ENOG4105FBD synthase HEP87_RS44910 ENOG4105EWU Squalene--hopene cyclase HEP87_RS44925 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HEP87_RS44950 ENOG4105M2Z protein tyrosine serine phosphatase HEP87_RS44990 ENOG4105D82 Glutamate dehydrogenase HEP87_RS44995 ENOG4105C7K acetolactate synthase HEP87_RS45040 ENOG4105CPQ Dehydrogenase HEP87_RS45045 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HEP87_RS45050 ENOG4106NZI LysR family Transcriptional regulator HEP87_RS45140 ENOG4105C0F tryptophanase EC 4.1.99.1 HEP87_RS45160 ENOG4105XTG Pfam:DUF156 HEP87_RS45180 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HEP87_RS45210 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HEP87_RS45295 ENOG4107RQ0 Maleylacetate reductase HEP87_RS45300 ENOG4105ETS cytosine purines uracil thiamine allantoin HEP87_RS45305 ENOG4105DWF phosphomethylpyrimidine kinase HEP87_RS45390 ENOG41079R3 acyl carrier protein HEP87_RS45400 ENOG4105KTE polyketide synthesis cyclase HEP87_RS45415 ENOG4105E9K Isocitrate dehydrogenase HEP87_RS45425 ENOG4105D64 Mechanosensitive ion channel HEP87_RS45430 ENOG4105E39 Enoyl-CoA hydratase HEP87_RS45445 ENOG4105EYF MMPL domain protein HEP87_RS45465 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HEP87_RS45475 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP87_RS45490 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HEP87_RS45505 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HEP87_RS45540 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HEP87_RS45565 ENOG4105CM2 brancheD-chain amino acid aminotransferase HEP87_RS45580 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP87_RS45585 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HEP87_RS45590 ENOG4105T38 integral membrane protein HEP87_RS45595 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HEP87_RS45605 ENOG4105D5U fad dependent oxidoreductase HEP87_RS45615 ENOG4108Z4U Ferredoxin HEP87_RS45620 ENOG4105C5Q Transcriptional regulator HEP87_RS45655 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HEP87_RS45670 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HEP87_RS45695 ENOG4107QPH glycogen) synthase HEP87_RS45700 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HEP87_RS45720 ENOG4105FQP Beta-lactamase HEP87_RS45725 ENOG4108R85 Short chain dehydrogenase HEP87_RS45735 ENOG4108M4U conserved membrane protein HEP87_RS45770 ENOG41060NJ transcriptional regulator HEP87_RS45810 ENOG41073TP transcriptional regulator HEP87_RS45820 ENOG4105C2J ABC transporter HEP87_RS45825 ENOG4105CNN ABC, transporter HEP87_RS45830 ENOG4105DIA mandelate racemase muconate lactonizing HEP87_RS45835 ENOG4105CHR reductase HEP87_RS45905 ENOG4105CRK lysyL-tRNA synthetase HEP87_RS45910 ENOG4108ZJ4 polysaccharide deacetylase HEP87_RS45965 ENOG4105CHR reductase HEP87_RS45970 ENOG4105C5Q Transcriptional regulator HEP87_RS45985 ENOG4105E33 succinate dehydrogenase HEP87_RS46005 ENOG4105DEN Luciferase family HEP87_RS46020 ENOG4105CPC Aldo Keto reductase HEP87_RS46025 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HEP87_RS46105 ENOG4105DU6 RNA polymerase HEP87_RS46145 ENOG41067HS methyltransferase HEP87_RS46150 ENOG4108V75 Glutamine amidotransferase HEP87_RS46155 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HEP87_RS46160 ENOG4105D1K glutamate--cysteine ligase HEP87_RS46185 ENOG4105DZ6 Band 7 protein HEP87_RS46200 ENOG41060NJ transcriptional regulator HEP87_RS46215 ENOG41080RH Thioredoxin HEP87_RS46225 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HEP87_RS46275 ENOG4105EUB pirin domain protein HEP87_RS46295 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP87_RS46305 ENOG4108XNA Gas vesicle HEP87_RS46310 ENOG4107ETC gas vesicle protein HEP87_RS46320 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HEP87_RS46335 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HEP87_RS46380 ENOG4105VBF alkaline shock protein HEP87_RS46485 ENOG4105VUF Transcriptional regulator HEP87_RS46490 ENOG4105CPC Aldo Keto reductase HEP87_RS46500 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS46540 ENOG4105CSH Transporter HEP87_RS46580 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS46585 ENOG4105CWX Alpha-1,2-mannosidase HEP87_RS46630 ENOG4105J0Q Transcriptional regulator HEP87_RS46635 ENOG4105CIS alcohol dehydrogenase HEP87_RS46645 ENOG410667J hydrolase HEP87_RS46725 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HEP87_RS46730 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HEP87_RS46735 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HEP87_RS46740 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HEP87_RS46745 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP87_RS46765 ENOG4108ZJI phenylacetic acid degradation protein HEP87_RS46780 ENOG4107QTZ amino acid HEP87_RS46835 ENOG4105C57 major facilitator superfamily HEP87_RS46845 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HEP87_RS46865 ENOG4105DSG hydrolase family 43 HEP87_RS46870 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HEP87_RS46880 ENOG4105DPX Hydrogenase, large subunit HEP87_RS46910 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HEP87_RS46930 ENOG4105CQS hydrogenase expression formation protein HypD HEP87_RS46965 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein HEP87_RS46995 ENOG4105E90 ABC transporter HEP87_RS47000 ENOG4105E90 ABC transporter HEP87_RS47010 ENOG4108TM9 integral membrane protein HEP87_RS47030 ENOG4108IJ8 ABC transporter HEP87_RS47035 ENOG41080R8 Conserved Protein HEP87_RS47045 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HEP87_RS47075 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HEP87_RS47080 ENOG4105F5R ABC transporter HEP87_RS47085 ENOG4105D4B ABC, transporter HEP87_RS47100 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS47110 ENOG4108KPJ rna polymerase sigma factor HEP87_RS47115 ENOG4105DDN Pentapeptide repeat-containing protein HEP87_RS47120 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HEP87_RS47125 ENOG4108R86 Transcriptional regulator HEP87_RS47135 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HEP87_RS47190 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HEP87_RS47235 ENOG4105DCG PHP domain protein HEP87_RS47275 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HEP87_RS47295 ENOG4105C26 Dehydrogenase HEP87_RS47310 ENOG4105ECQ AraC Family Transcriptional Regulator HEP87_RS47335 ENOG4107RCI amp-dependent synthetase and ligase HEP87_RS47350 ENOG4107EEY synthase HEP87_RS47380 ENOG4105CUB amino acid HEP87_RS47405 ENOG4105PGM cation diffusion facilitator family transporter HEP87_RS47420 ENOG4106YKD Cytochrome p-450 HEP87_RS47460 ENOG4105EBM Alpha Beta Hydrolase Fold protein HEP87_RS47500 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP87_RS47540 ENOG4108JQ1 Dehydrogenase HEP87_RS47545 ENOG4105DMF Dehydrogenase HEP87_RS47570 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HEP87_RS47580 ENOG4106C4P Strong inhibitor of bacterial serine proteases such as subtilisin (By similarity) HEP87_RS47590 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HEP87_RS47600 ENOG41060NJ transcriptional regulator HEP87_RS47635 ENOG4108JJA ABC, transporter HEP87_RS47640 ENOG4108JJA ABC, transporter HEP87_RS47675 ENOG4105EXC Acyl-transferase HEP87_RS47750 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEP87_RS47765 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HEP87_RS47895 ENOG4105E2R ROK family HEP87_RS47945 ENOG4108KPJ rna polymerase sigma factor HEP87_RS47995 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP87_RS48025 ENOG4105C5Q Transcriptional regulator HEP87_RS48030 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP87_RS48035 ENOG4105CHR reductase HEP87_RS48045 ENOG4105CHR reductase HEP87_RS48080 ENOG41068HZ 50S ribosomal protein L32 HEP87_RS48085 ENOG4105D0U Arsenite-activated ATPase (ArsA) HEP87_RS48145 ENOG4107R7A Allophanate hydrolase subunit 2 HEP87_RS48150 ENOG4105CSH Transporter HEP87_RS48165 ENOG4105JSC dimethylmenaquinone methyltransferase HEP87_RS48170 ENOG4108PVQ transcriptional regulator HEP87_RS48245 ENOG4105C26 Dehydrogenase HEP87_RS48250 ENOG4107RSM transcriptional regulator HEP87_RS48265 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HEP87_RS48400 ENOG4105VDT -acetyltransferase HEP87_RS48410 ENOG4105VEQ Cold shock protein HEP87_RS48445 ENOG4105DEG Vwa containing coxe family protein HEP87_RS48450 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HEP87_RS48465 ENOG4108JPW Aminotransferase HEP87_RS48470 ENOG4107B7Y DNA-binding transcriptional regulator FruR HEP87_RS48500 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEP87_RS48525 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HEP87_RS48530 ENOG4105DRS transport system, permease HEP87_RS48545 ENOG4105CS9 pantothenic acid kinase HEP87_RS48565 ENOG4105K4I Scp-like extracellular HEP87_RS48605 ENOG4105EGE secreted protein HEP87_RS48610 ENOG4106UDK Cellulose-binding, family II HEP87_RS48630 ENOG4107SET aldo keto reductase HEP87_RS48635 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP87_RS48640 ENOG4105CWX Alpha-1,2-mannosidase HEP87_RS48700 ENOG41082J7 Rhodanese domain protein HEP87_RS48705 ENOG4108VCT Sulfite exporter TauE/SafE HEP87_RS48710 ENOG4105VPX protein, conserved in bacteria HEP87_RS48745 ENOG4105D29 Helix-turn-helix type 11 domain protein HEP87_RS48750 ENOG4105HHS UPF0256 protein HEP87_RS48780 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP87_RS48795 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS48805 ENOG4105EX0 alpha-galactosidase HEP87_RS48815 ENOG4107S5I aldo keto reductase HEP87_RS48840 ENOG4105CUX Signal transduction histidine kinase HEP87_RS48845 ENOG4105C3M thioredoxin reductase HEP87_RS48910 ENOG4105IDI abc transporter atp-binding protein HEP87_RS48940 ENOG4105DR5 peptidase HEP87_RS48960 ENOG4105DND Transcriptional regulator HEP87_RS48965 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEP87_RS48995 ENOG4105C4C beta-galactosidase HEP87_RS49015 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS49020 ENOG4105D3W isochorismatase HEP87_RS49030 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HEP87_RS49035 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HEP87_RS49050 ENOG4105EMN RNA polymerase sigma factor HEP87_RS49080 ENOG4105BZU Histidine kinase HEP87_RS49100 ENOG4108U3T pfkb domain protein HEP87_RS49110 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HEP87_RS49175 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) HEP87_RS49180 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP87_RS49235 ENOG4108S01 response regulator HEP87_RS49265 ENOG4105BZU Histidine kinase HEP87_RS49275 ENOG4105CJW magnesium transporter HEP87_RS49320 ENOG4105CSR polyphosphate kinase 2 HEP87_RS49325 ENOG4107QRI Phosphoketolase HEP87_RS49330 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEP87_RS49355 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HEP87_RS49375 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HEP87_RS49425 ENOG41068KF Universal stress protein HEP87_RS49440 ENOG4105E2A Dehydrogenase HEP87_RS49455 ENOG4105D5Q Arginine ornithine antiporter HEP87_RS49460 ENOG4105CEU Arginine dihydrolase HEP87_RS49465 ENOG4105DBV ornithine carbamoyltransferase HEP87_RS49480 ENOG4105F1A Pyruvate formate-lyase HEP87_RS49515 ENOG4105E1F short-chain dehydrogenase reductase HEP87_RS49535 ENOG4105VEQ Cold shock protein HEP87_RS49540 ENOG4105C1J atp-dependent rna helicase HEP87_RS49595 ENOG4108JJA ABC, transporter HEP87_RS49680 ENOG4105CIG ABC transporter HEP87_RS49720 ENOG41080UQ Transcriptional regulator HEP87_RS49735 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEP87_RS49740 ENOG4108Z6Z Transcriptional regulator HEP87_RS49805 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP87_RS49825 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP87_RS49850 ENOG4107RTG Major Facilitator superfamily HEP87_RS49875 ENOG4108PBA serine threonine protein kinase HEP87_RS49880 ENOG4105BZ1 (ABC) transporter HEP87_RS49920 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEP87_RS49925 ENOG4108Z6Z Transcriptional regulator HEP87_RS49935 ENOG4107RDT Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP87_RS49950 ENOG4105CYP glycoside hydrolase, family HEP87_RS49955 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HEP87_RS49960 ENOG4105HSS phospholipase C HEP87_RS49975 ENOG4105DUM transcriptional regulator, lysR family HEP87_RS49980 ENOG4105DIA mandelate racemase muconate lactonizing HEP87_RS49985 ENOG4105CHR reductase HEP87_RS49995 ENOG4105E2R ROK family HEP87_RS50000 ENOG4105EX0 alpha-galactosidase HEP87_RS50010 ENOG4105EG2 ABC transporter, permease HEP87_RS50035 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP87_RS50045 ENOG4105CHJ isochorismatase hydrolase HEP87_RS50055 ENOG4107SET aldo keto reductase HEP87_RS50080 ENOG4105CHR reductase HEP87_RS50085 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEP87_RS50160 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP87_RS50225 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HEP87_RS50360 ENOG410836F Transposase HEP87_RS50440 ENOG4108XSB acetyltransferase, (GNAT) family HEP87_RS50465 ENOG41066YJ Beta-lactamase HEP87_RS50475 ENOG4105E2A Dehydrogenase HEP87_RS50495 ENOG4105CHR reductase HEP87_RS50505 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HEP87_RS50530 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HEP87_RS50540 ENOG4105EZR dyp-type peroxidase family protein HEP87_RS50590 ENOG4108MP6 LysR family Transcriptional regulator HEP87_RS50650 ENOG41061H0 Monooxygenase HEP87_RS50680 ENOG4105CNN ABC, transporter HEP87_RS50685 ENOG4105C2J ABC transporter HEP87_RS50690 ENOG4108MJI response regulator HEP87_RS50710 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS50715 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEP87_RS50740 ENOG4107QN2 dihydrolipoyl dehydrogenase HEP87_RS50790 ENOG4105C5X domain protein HEP87_RS50805 ENOG4105F7P transcriptional regulator AsnC family HEP87_RS50825 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP87_RS50845 ENOG4105EUB pirin domain protein HEP87_RS50850 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP87_RS50925 ENOG4105S7M extracellular small neutral protease HEP87_RS51000 ENOG4105CGS Alpha-glucosidase HEP87_RS51010 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEP87_RS51055 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP87_RS51090 ENOG4105FBN Acid phosphatase HEP87_RS51115 ENOG4107QTZ amino acid HEP87_RS51270 ENOG4106A3M Cytochrome p-450 HEP87_RS51360 ENOG4105CH7 arginosuccinase HEP87_RS51380 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP87_RS51385 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HEP87_RS51505 ENOG4105D74 hydrolase HEP87_RS51525 ENOG4105E5D amino acid HEP87_RS51540 ENOG4105EMU Dehydrogenase HEP87_RS51565 ENOG4105GRZ Ycii-related protein HEP87_RS51610 ENOG4106A3M Cytochrome p-450 HEP87_RS51620 ENOG4108Z40 Transcriptional regulator HEP87_RS51625 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP87_RS51635 ENOG4105BZU Histidine kinase HEP87_RS51640 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS51675 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS51680 ENOG4105BZU Histidine kinase HEP87_RS51720 ENOG4105CQB FAD linked oxidase domain protein HEP87_RS51725 ENOG4105E39 Enoyl-CoA hydratase HEP87_RS51750 ENOG4108JNI Alpha beta hydrolase HEP87_RS51765 ENOG4108Z6Z Transcriptional regulator HEP87_RS51785 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP87_RS51795 ENOG4105C26 Dehydrogenase HEP87_RS51800 ENOG4105C1B dTDP-glucose 4-6-dehydratase HEP87_RS51815 ENOG4108IG5 Transcriptional regulator HEP87_RS51880 ENOG4108JGH Tetr family transcriptional regulator HEP87_RS51915 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEP87_RS51925 ENOG4108R96 Methyltransferase, YaeB family HEP87_RS51940 ENOG4108KPJ rna polymerase sigma factor HEP87_RS52025 ENOG4108JA1 polyketide synthase HEP87_RS52065 ENOG4105E1F short-chain dehydrogenase reductase HEP87_RS52110 ENOG4105ECQ AraC Family Transcriptional Regulator HEP87_RS52230 ENOG4105ERH Fumarylacetoacetate hydrolase HEP87_RS52275 ENOG4105DND Transcriptional regulator HEP87_RS52305 ENOG4108Q9V regulatoR HEP87_RS52320 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS52325 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS52330 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HEP87_RS52335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP87_RS52345 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS52360 ENOG4105EQN UPF0261 protein HEP87_RS52420 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HEP87_RS52485 ENOG4105EMN RNA polymerase sigma factor HEP87_RS52570 ENOG41085W3 Transposase HEP87_RS52580 ENOG4105EXG Transcriptional regulator HEP87_RS52610 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP87_RS52640 ENOG4105CSH Transporter HEP87_RS52690 ENOG4105EYF MMPL domain protein HEP87_RS52705 ENOG4105H3G oxidoreductase HEP87_RS52715 ENOG4105C26 Dehydrogenase HEP87_RS52720 ENOG4108ZX5 transcriptional regulator HEP87_RS52725 ENOG4106UW1 Major Facilitator superfamily HEP87_RS52750 ENOG4108W6C Dehydrogenase HEP87_RS52760 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HEP87_RS52765 ENOG4105CPC Aldo Keto reductase HEP87_RS52775 ENOG4105BZU Histidine kinase HEP87_RS52780 ENOG4105WH1 Two component transcriptional regulator luxr family HEP87_RS52840 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HEP87_RS52865 ENOG4108IG5 Transcriptional regulator HEP87_RS52940 ENOG4105D7V transposase HEP87_RS53015 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP87_RS53020 ENOG4105CHR reductase HEP87_RS53025 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HEP87_RS53035 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HEP87_RS53050 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP87_RS53060 ENOG4105CPC Aldo Keto reductase HEP87_RS53070 ENOG4105D7V transposase HEP87_RS53110 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEP87_RS53140 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HEP87_RS53175 ENOG4105CHJ isochorismatase hydrolase HEP87_RS53180 ENOG4105XPP Protein of unknown function (DUF1275) HEP87_RS53190 ENOG4108VGI doxx family HEP87_RS53215 ENOG4105D7V transposase HEP87_RS53285 ENOG4105EZE Cupin 4 family protein HEP87_RS53310 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HEP87_RS53405 ENOG4105BZP glycoside hydrolase 15-related HEP87_RS53430 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP87_RS53440 ENOG4108KPJ rna polymerase sigma factor HEP87_RS53500 ENOG4105ETE Transcriptional regulator (LacI family HEP87_RS53515 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HEP87_RS53575 ENOG4107HP6 Transcriptional regulator HEP87_RS53610 ENOG4105CS1 NAD(P)H quinone oxidoreductase HEP87_RS53690 ENOG4105FP9 thiamine pyrophosphate HEP87_RS53695 ENOG4105CHR reductase HEP87_RS53700 ENOG4108XG4 DNA-binding transcriptional regulator HEP87_RS53705 ENOG4105E1F short-chain dehydrogenase reductase HEP87_RS53715 ENOG4105DMF Dehydrogenase HEP87_RS53720 ENOG4105D7V transposase HEP87_RS53740 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEP87_RS53745 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEP87_RS53785 ENOG4108UAU isochorismatase HEP87_RS53900 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP87_RS53915 ENOG4105CHR reductase HEP87_RS53930 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HEP87_RS53970 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HEP87_RS53975 ENOG4105CMG Carbohydrate kinase HEP87_RS53980 ENOG4108YZG isomerase HEP87_RS53985 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEP87_RS53990 ENOG4105C2J ABC transporter HEP87_RS53995 ENOG4105CNN ABC, transporter HEP87_RS54000 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEP87_RS54005 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEP87_RS54040 ENOG4107258 Transcriptional regulator HEP87_RS54080 ENOG4107R5T Cysteine-rich domain HEP87_RS54125 ENOG4105ENX hydrolase HEP87_RS54160 ENOG4105E5W Transporter HEP87_RS54220 ENOG4105D5G Transposase HEP87_RS54225 ENOG4105KF0 sporulation and cell division protein, SsgA HEP87_RS54265 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HEP87_RS54270 ENOG4108KC1 acyl-Coa dehydrogenase HEP87_RS54285 ENOG4105C2J ABC transporter HEP87_RS54325 ENOG4105BZU Histidine kinase HEP87_RS54330 ENOG4105ERH Fumarylacetoacetate hydrolase HEP87_RS54335 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HEP87_RS54345 ENOG4105C87 Aminotransferase class I and II HEP87_RS54350 ENOG4107QTZ amino acid HEP87_RS54370 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP87_RS54390 ENOG4108J59 Extracellular solute-binding protein, family 5 HEP87_RS54395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP87_RS54400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP87_RS54440 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEP87_RS54525 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP87_RS54535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS54565 ENOG4105D8K carboxyl transferase HEP87_RS54570 ENOG4105CHR reductase HEP87_RS54605 ENOG4105KTE polyketide synthesis cyclase HEP87_RS54615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP87_RS54620 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HEP87_RS54630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP87_RS54665 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEP87_RS54700 ENOG4105F27 Major Facilitator HEP87_RS54710 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HEP87_RS54710 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HEP87_RS54715 ENOG4105CK2 sodium dicarboxylate symporter HEP87_RS54720 ENOG4105C7F AcnD-accessory protein PrpF HEP87_RS54730 ENOG4108W5M transcriptional regulator HEP87_RS54735 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP87_RS54745 ENOG4105D2B acyl-CoA dehydrogenase HEP87_RS54755 ENOG4105CHR reductase HEP87_RS54760 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS54800 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HEP87_RS54805 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HEP87_RS54810 ENOG4107SVN transposase HEP87_RS54815 ENOG4105C7W Xanthine dehydrogenase HEP87_RS54845 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP87_RS54910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP87_RS54930 ENOG4105CHR reductase HEP87_RS54935 ENOG4105CHR reductase HEP87_RS54940 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS54965 ENOG4105C26 Dehydrogenase HEP87_RS54985 ENOG4108KPJ rna polymerase sigma factor HEP87_RS54995 ENOG4108IND Tetr family transcriptional regulator HEP87_RS55000 ENOG4108IG5 Transcriptional regulator HEP87_RS55005 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP87_RS55045 ENOG4107W6X Transcriptional regulator HEP87_RS55090 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HEP87_RS55145 ENOG4105C10 Electron transfer flavoprotein HEP87_RS55190 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) HEP87_RS55195 ENOG4105C5X domain protein HEP87_RS55210 ENOG4105CGU Enoyl-CoA hydratase HEP87_RS55220 ENOG4105CEY Amp-dependent synthetase and ligase HEP87_RS55225 ENOG4105C1G acyl-Coa dehydrogenase HEP87_RS55230 ENOG4105CI0 Citrate lyase HEP87_RS55235 ENOG4105DJG MaoC domain protein dehydratase HEP87_RS55245 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F HEP87_RS55265 ENOG4105D1K glutamate--cysteine ligase HEP87_RS55280 ENOG41067HS methyltransferase HEP87_RS55310 ENOG4108M8W Monooxygenase HEP87_RS55355 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HEP87_RS55360 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HEP87_RS55365 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEP87_RS55370 ENOG4105D7V transposase HEP87_RS55395 ENOG4105KVH Transcriptional regulator HEP87_RS55410 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HEP87_RS55430 ENOG4105KVH Transcriptional regulator HEP87_RS55435 ENOG4107S5I aldo keto reductase HEP87_RS55445 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP87_RS55490 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP87_RS55495 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HEP87_RS55505 ENOG4105C5Q Transcriptional regulator HEP87_RS55515 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP87_RS55520 ENOG4105CGU Enoyl-CoA hydratase HEP87_RS55525 ENOG4105CHU acetyl-coa acetyltransferase HEP87_RS55530 ENOG4105E39 Enoyl-CoA hydratase HEP87_RS55535 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP87_RS55545 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP87_RS55680 ENOG4105FDF Could be involved in DNA repair (By similarity) HEP87_RS55795 ENOG41085W3 Transposase HEP87_RS55845 ENOG4108BUD transposase HEP87_RS55895 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP87_RS55900 ENOG4105CHR reductase HEP87_RS55980 ENOG4105PWE CRISPR-associated protein cas2 HEP87_RS55995 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEP87_RS56005 ENOG4105C8Y Acetylornithine aminotransferase HEP87_RS56165 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HEP87_RS56260 ENOG4105IJJ transcriptional regulator, crp fnr family HEP87_RS56320 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)