locus-tag	class	description
HEP87_RS00195	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP87_RS00195	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP87_RS00195	COG0567	Dehydrogenase, E1 component
HEP87_RS00195	COG0567	Dehydrogenase, E1 component
HEP87_RS00240	COG1090	epimerase
HEP87_RS00295	COG3328	transposase activity
HEP87_RS00300	COG0583	DNA-binding transcription factor activity
HEP87_RS00330	COG3385	transposase activity
HEP87_RS00380	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS00390	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS00480	COG1660	Displays ATPase and GTPase activities
HEP87_RS00505	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HEP87_RS00530	COG0596	Alpha beta hydrolase
HEP87_RS00540	COG1309	transcriptional regulator
HEP87_RS00545	COG1902	pentaerythritol trinitrate reductase activity
HEP87_RS00545	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP87_RS00640	COG0596	Alpha beta hydrolase
HEP87_RS00650	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP87_RS00670	COG4585	Histidine kinase
HEP87_RS00675	COG2197	response regulator
HEP87_RS00775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP87_RS00785	COG1280	lysine exporter protein (LysE YggA)
HEP87_RS00790	COG0596	Alpha beta hydrolase
HEP87_RS00810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP87_RS00820	COG2801	Transposase and inactivated derivatives
HEP87_RS00830	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS00850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP87_RS00850	COG1017	nitric oxide dioxygenase activity
HEP87_RS00860	COG0596	Alpha beta hydrolase
HEP87_RS00885	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HEP87_RS00930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP87_RS01190	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HEP87_RS01195	COG1687	branched-chain amino acid
HEP87_RS01230	COG0477	Major facilitator Superfamily
HEP87_RS01265	COG1793	dna ligase
HEP87_RS01370	COG1802	Transcriptional regulator
HEP87_RS01415	COG2205	protein histidine kinase activity
HEP87_RS01420	COG0745	RESPONSE REGULATOR receiver
HEP87_RS01430	COG2409	Drug exporters of the RND superfamily
HEP87_RS01440	COG1178	ABC-type Fe3 transport system permease component
HEP87_RS01445	COG3842	ATPase activity
HEP87_RS01560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP87_RS01635	COG1733	regulation of RNA biosynthetic process
HEP87_RS01640	COG0604	alcohol dehydrogenase
HEP87_RS01710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP87_RS01790	COG3328	transposase activity
HEP87_RS01915	COG0789	Transcriptional regulator
HEP87_RS01940	COG0842	Transport permease protein
HEP87_RS01940	COG1131	(ABC) transporter
HEP87_RS01940	COG1716	ATPase activity
HEP87_RS02030	COG3629	intracellular signal transduction
HEP87_RS02030	COG3903	Transcriptional regulator
HEP87_RS02105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP87_RS02110	COG2267	carboxylic ester hydrolase activity
HEP87_RS02175	COG0667	Aldo Keto reductase
HEP87_RS02190	COG1120	ATPase activity
HEP87_RS02195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP87_RS02210	COG3433	isochorismatase activity
HEP87_RS02210	COG1535	isochorismatase
HEP87_RS02230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP87_RS02310	COG0384	phenazine biosynthesis protein PhzF
HEP87_RS02335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP87_RS02355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP87_RS02365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HEP87_RS02395	COG0697	spore germination
HEP87_RS02485	COG1175	transmembrane transport
HEP87_RS02490	COG0395	ABC-type sugar transport system, permease component
HEP87_RS02525	COG0655	NAD(P)H dehydrogenase (quinone) activity
HEP87_RS02540	COG1309	transcriptional regulator
HEP87_RS02545	COG1902	pentaerythritol trinitrate reductase activity
HEP87_RS02565	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS02580	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS02585	COG1309	transcriptional regulator
HEP87_RS02590	COG0667	Aldo Keto reductase
HEP87_RS02595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP87_RS02630	COG4948	Mandelate Racemase Muconate Lactonizing
HEP87_RS02655	COG1175	transmembrane transport
HEP87_RS02670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP87_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS02790	COG0583	DNA-binding transcription factor activity
HEP87_RS02800	COG2197	response regulator
HEP87_RS02815	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS02840	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS02860	COG0789	Transcriptional regulator
HEP87_RS02895	COG1073	alpha beta
HEP87_RS02910	COG0667	Aldo Keto reductase
HEP87_RS02925	COG1233	COG1233 Phytoene dehydrogenase and related
HEP87_RS02950	COG1609	Transcriptional regulator
HEP87_RS02965	COG0395	ABC-type sugar transport system, permease component
HEP87_RS03000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP87_RS03010	COG1271	oxidase subunit
HEP87_RS03015	COG0477	Major facilitator Superfamily
HEP87_RS03030	COG0395	ABC-type sugar transport system, permease component
HEP87_RS03045	COG1609	Transcriptional regulator
HEP87_RS03070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEP87_RS03090	COG0667	Aldo Keto reductase
HEP87_RS03095	COG2814	Major facilitator Superfamily
HEP87_RS03155	COG1324	tolerance protein
HEP87_RS03185	COG3387	PFAM Glycoside hydrolase 15-related
HEP87_RS03210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP87_RS03365	COG3344	reverse transcriptase
HEP87_RS03490	COG2197	response regulator
HEP87_RS03495	COG0596	Alpha beta hydrolase
HEP87_RS03495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP87_RS03495	COG2226	methyltransferase
HEP87_RS03500	COG1024	Enoyl-CoA hydratase
HEP87_RS03500	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS03510	COG0604	alcohol dehydrogenase
HEP87_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS03535	COG2318	DinB family
HEP87_RS03550	COG3655	Transcriptional regulator
HEP87_RS03605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP87_RS03605	COG0519	Catalyzes the synthesis of GMP from XMP
HEP87_RS03620	COG0675	Transposase, IS605 OrfB family
HEP87_RS03630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP87_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS03650	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS03655	COG2188	Transcriptional regulator
HEP87_RS03665	COG1175	transmembrane transport
HEP87_RS03670	COG0395	ABC-type sugar transport system, permease component
HEP87_RS03735	COG1609	Transcriptional regulator
HEP87_RS03750	COG0673	inositol 2-dehydrogenase activity
HEP87_RS03755	COG1082	Xylose isomerase domain protein TIM barrel
HEP87_RS03765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP87_RS03775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP87_RS03805	COG3469	chitinase activity
HEP87_RS03845	COG2132	Multicopper oxidase
HEP87_RS03860	COG0473	3-isopropylmalate dehydrogenase activity
HEP87_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS03870	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS03875	COG1764	response to oxidative stress
HEP87_RS03950	COG2770	Histidine kinase
HEP87_RS03950	COG2208	phosphoserine phosphatase activity
HEP87_RS04045	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEP87_RS04075	COG2197	response regulator
HEP87_RS04100	COG1082	Xylose isomerase domain protein TIM barrel
HEP87_RS04105	COG0673	inositol 2-dehydrogenase activity
HEP87_RS04110	COG1082	Xylose isomerase domain protein TIM barrel
HEP87_RS04135	COG2226	methyltransferase
HEP87_RS04140	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP87_RS04170	COG4213	ABC transporter substrate-binding protein
HEP87_RS04180	COG4213	ABC transporter substrate-binding protein
HEP87_RS04200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP87_RS04205	COG1414	Transcriptional regulator
HEP87_RS04230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP87_RS04240	COG0640	Transcriptional regulator
HEP87_RS04260	COG0667	Aldo Keto reductase
HEP87_RS04265	COG0222	ribosome binding
HEP87_RS04290	COG0395	ABC-type sugar transport system, permease component
HEP87_RS04305	COG0477	Major facilitator Superfamily
HEP87_RS04330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP87_RS04335	COG1120	ATPase activity
HEP87_RS04405	COG1191	sigma factor activity
HEP87_RS04410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP87_RS04490	COG1609	Transcriptional regulator
HEP87_RS04495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP87_RS04500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP87_RS04500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP87_RS04505	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HEP87_RS04515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HEP87_RS04525	COG1064	alcohol dehydrogenase
HEP87_RS04530	COG1063	alcohol dehydrogenase
HEP87_RS04545	COG0009	L-threonylcarbamoyladenylate synthase
HEP87_RS04560	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP87_RS04590	COG1414	Transcriptional regulator
HEP87_RS04595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP87_RS04600	COG2610	gluconate transmembrane transporter activity
HEP87_RS04605	COG4948	Mandelate Racemase Muconate Lactonizing
HEP87_RS04620	COG1136	(ABC) transporter
HEP87_RS04625	COG4585	Histidine kinase
HEP87_RS04630	COG2197	response regulator
HEP87_RS04635	COG1309	transcriptional regulator
HEP87_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS04665	COG3962	Belongs to the TPP enzyme family
HEP87_RS04675	COG0579	oxidoreductase
HEP87_RS04680	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS04725	COG0583	DNA-binding transcription factor activity
HEP87_RS04735	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP87_RS04740	COG1129	ABC transporter
HEP87_RS04770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP87_RS04775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP87_RS04780	COG2186	Transcriptional regulator
HEP87_RS04790	COG1609	Transcriptional regulator
HEP87_RS04815	COG0477	Major facilitator Superfamily
HEP87_RS04870	COG0464	growth
HEP87_RS04970	COG1846	Transcriptional regulator
HEP87_RS04970	COG1940	carbohydrate kinase activity
HEP87_RS05020	COG1881	PFAM PEBP family protein
HEP87_RS05035	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS05040	COG2186	Transcriptional regulator
HEP87_RS05045	COG1024	Enoyl-CoA hydratase
HEP87_RS05050	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS05055	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS05060	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS05070	COG1024	Enoyl-CoA hydratase
HEP87_RS05075	COG0183	Belongs to the thiolase family
HEP87_RS05080	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS05085	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS05150	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS05165	COG2272	Belongs to the type-B carboxylesterase lipase family
HEP87_RS05170	COG1024	Enoyl-CoA hydratase
HEP87_RS05190	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS05210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS05215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS05220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS05220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS05225	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS05235	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS05245	COG1024	Enoyl-CoA hydratase
HEP87_RS05255	COG1309	transcriptional regulator
HEP87_RS05295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP87_RS05300	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS05315	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS05325	COG4638	Rieske (2fe-2S)
HEP87_RS05345	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS05355	COG3321	synthase
HEP87_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS05355	COG0604	alcohol dehydrogenase
HEP87_RS05405	COG1309	transcriptional regulator
HEP87_RS05425	COG2814	Major facilitator Superfamily
HEP87_RS05475	COG0277	FAD linked oxidase domain protein
HEP87_RS05490	COG0366	Alpha amylase catalytic
HEP87_RS05500	COG3281	Trehalose synthase
HEP87_RS05545	COG0596	Alpha beta hydrolase
HEP87_RS05585	COG0477	Major facilitator Superfamily
HEP87_RS05610	COG0494	nUDIX hydrolase
HEP87_RS05620	COG2273	Hydrolase Family 16
HEP87_RS05625	COG1609	Transcriptional regulator
HEP87_RS05655	COG3345	alpha-galactosidase
HEP87_RS05660	COG0395	ABC-type sugar transport system, permease component
HEP87_RS05665	COG1175	transmembrane transport
HEP87_RS05675	COG1940	carbohydrate kinase activity
HEP87_RS05675	COG1846	Transcriptional regulator
HEP87_RS05695	COG0438	transferase activity, transferring glycosyl groups
HEP87_RS05700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HEP87_RS05710	COG1760	l-serine dehydratase
HEP87_RS05715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP87_RS05720	COG0509	glycine decarboxylation via glycine cleavage system
HEP87_RS05765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP87_RS05780	COG4176	ABC-type proline glycine betaine transport system permease component
HEP87_RS05785	COG4175	Glycine betaine
HEP87_RS05785	COG0517	IMP dehydrogenase activity
HEP87_RS05790	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS05820	COG4638	Rieske (2fe-2S)
HEP87_RS05835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP87_RS05880	COG1408	metallophosphoesterase
HEP87_RS05920	COG3629	intracellular signal transduction
HEP87_RS05920	COG3903	Transcriptional regulator
HEP87_RS05995	COG0363	glucosamine-6-phosphate deaminase activity
HEP87_RS06000	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP87_RS06045	COG0431	NADPH-dependent FMN reductase
HEP87_RS06100	COG2304	oxidoreductase activity
HEP87_RS06165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS06195	COG0596	Alpha beta hydrolase
HEP87_RS06200	COG0740	serine-type endopeptidase activity
HEP87_RS06205	COG0740	serine-type endopeptidase activity
HEP87_RS06215	COG2318	DinB family
HEP87_RS06230	COG0784	Response regulator, receiver
HEP87_RS06235	COG4251	negative regulation of phosphorylation
HEP87_RS06300	COG0842	Transport permease protein
HEP87_RS06300	COG1716	ATPase activity
HEP87_RS06300	COG1131	(ABC) transporter
HEP87_RS06330	COG0583	DNA-binding transcription factor activity
HEP87_RS06345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP87_RS06350	COG0346	lactoylglutathione lyase activity
HEP87_RS06360	COG0671	phosphoesterase, PA-phosphatase related
HEP87_RS06370	COG0412	Dienelactone hydrolase
HEP87_RS06375	COG0667	Aldo Keto reductase
HEP87_RS06385	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS06440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS06450	COG0431	NADPH-dependent FMN reductase
HEP87_RS06535	COG2318	DinB family
HEP87_RS06625	COG3250	beta-galactosidase activity
HEP87_RS06655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP87_RS06675	COG0667	Aldo Keto reductase
HEP87_RS06705	COG0367	asparagine synthase
HEP87_RS06710	COG0069	glutamate synthase activity
HEP87_RS06715	COG2235	arginine
HEP87_RS06730	COG0673	inositol 2-dehydrogenase activity
HEP87_RS06735	COG3511	phospholipase C
HEP87_RS06845	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS06935	COG1063	alcohol dehydrogenase
HEP87_RS06970	COG0006	proline dipeptidase activity
HEP87_RS06975	COG3291	Pkd domain containing protein
HEP87_RS06995	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS07025	COG1609	Transcriptional regulator
HEP87_RS07040	COG2188	Transcriptional regulator
HEP87_RS07050	COG3962	Belongs to the TPP enzyme family
HEP87_RS07055	COG3718	enzyme involved in inositol metabolism
HEP87_RS07065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP87_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS07105	COG2072	flavoprotein involved in K transport
HEP87_RS07110	COG4638	Rieske (2fe-2S)
HEP87_RS07120	COG3386	PFAM SMP-30 Gluconolaconase
HEP87_RS07125	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS07130	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS07140	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS07155	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS07160	COG0427	acetyl-CoA hydrolase
HEP87_RS07170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP87_RS07180	COG2186	Transcriptional regulator
HEP87_RS07185	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS07200	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS07220	COG1335	isochorismatase
HEP87_RS07325	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEP87_RS07330	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP87_RS07335	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP87_RS07345	COG0531	amino acid
HEP87_RS07405	COG3548	integral membrane protein
HEP87_RS07415	COG0596	Alpha beta hydrolase
HEP87_RS07430	COG4555	ABC transporter
HEP87_RS07435	COG2124	cytochrome p450
HEP87_RS07445	COG2124	cytochrome p450
HEP87_RS07450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP87_RS07455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP87_RS07490	COG0492	ferredoxin-NADP+ reductase activity
HEP87_RS07505	COG2208	phosphoserine phosphatase activity
HEP87_RS07505	COG2770	Histidine kinase
HEP87_RS07565	COG0515	serine threonine protein kinase
HEP87_RS07620	COG0346	lactoylglutathione lyase activity
HEP87_RS07650	COG0650	Formate hydrogenlyase subunit 4
HEP87_RS07695	COG0659	secondary active sulfate transmembrane transporter activity
HEP87_RS07705	COG2824	Alkylphosphonate utilization operon protein PhnA
HEP87_RS07730	COG2267	carboxylic ester hydrolase activity
HEP87_RS07750	COG0656	L-ascorbic acid biosynthetic process
HEP87_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS07800	COG2124	cytochrome p450
HEP87_RS07860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEP87_RS08110	COG0667	Aldo Keto reductase
HEP87_RS08115	COG2072	flavoprotein involved in K transport
HEP87_RS08130	COG3321	synthase
HEP87_RS08130	COG0604	alcohol dehydrogenase
HEP87_RS08200	COG3619	membrane
HEP87_RS08240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP87_RS08260	COG3290	protein histidine kinase activity
HEP87_RS08315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP87_RS08335	COG2376	Dihydroxyacetone kinase
HEP87_RS08340	COG1461	Dihydroxyacetone kinase
HEP87_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS08385	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP87_RS08385	COG1902	pentaerythritol trinitrate reductase activity
HEP87_RS08390	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP87_RS08410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP87_RS08440	COG3458	cephalosporin-C deacetylase activity
HEP87_RS08465	COG2226	methyltransferase
HEP87_RS08470	COG0366	Alpha amylase catalytic
HEP87_RS08475	COG2267	carboxylic ester hydrolase activity
HEP87_RS08485	COG0300	oxidoreductase activity
HEP87_RS08490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP87_RS08530	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP87_RS08545	COG4941	Belongs to the sigma-70 factor family
HEP87_RS08555	COG3795	YCII-related domain
HEP87_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS08580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP87_RS08585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP87_RS08605	COG2066	Belongs to the glutaminase family
HEP87_RS08620	COG1113	amino acid transport
HEP87_RS08635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP87_RS08640	COG1993	acr, cog1993
HEP87_RS08645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP87_RS08670	COG1175	transmembrane transport
HEP87_RS08675	COG0395	ABC-type sugar transport system, permease component
HEP87_RS08695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HEP87_RS08720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP87_RS08725	COG1116	anion transmembrane transporter activity
HEP87_RS08735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS08770	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP87_RS08810	COG1215	transferase activity, transferring glycosyl groups
HEP87_RS08845	COG1349	DNA-binding transcription factor activity
HEP87_RS08870	COG0577	efflux transmembrane transporter activity
HEP87_RS08875	COG1136	(ABC) transporter
HEP87_RS08895	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HEP87_RS08910	COG2813	Specifically methylates the guanine in position
HEP87_RS08935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP87_RS08940	COG1349	DNA-binding transcription factor activity
HEP87_RS08955	COG1174	glycine betaine transport
HEP87_RS08975	COG2018	Roadblock/LC7 domain
HEP87_RS08995	COG2267	carboxylic ester hydrolase activity
HEP87_RS09005	COG3320	Male sterility
HEP87_RS09005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP87_RS09035	COG0596	Alpha beta hydrolase
HEP87_RS09040	COG4565	transcriptional regulatory protein
HEP87_RS09045	COG3290	protein histidine kinase activity
HEP87_RS09055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP87_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS09090	COG1271	oxidase subunit
HEP87_RS09100	COG3265	gluconokinase activity
HEP87_RS09145	COG3387	PFAM Glycoside hydrolase 15-related
HEP87_RS09185	COG2197	response regulator
HEP87_RS09190	COG4585	Histidine kinase
HEP87_RS09205	COG0445	tRNA wobble uridine modification
HEP87_RS09210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP87_RS09215	COG1660	Displays ATPase and GTPase activities
HEP87_RS09300	COG0395	ABC-type sugar transport system, permease component
HEP87_RS09345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEP87_RS09370	COG0204	Acyl-transferase
HEP87_RS09395	COG0584	glycerophosphoryl diester phosphodiesterase
HEP87_RS09455	COG1309	transcriptional regulator
HEP87_RS09480	COG0640	Transcriptional regulator
HEP87_RS09485	COG1902	pentaerythritol trinitrate reductase activity
HEP87_RS09500	COG2197	response regulator
HEP87_RS09505	COG4585	Histidine kinase
HEP87_RS09510	COG3963	phosphatidate phosphatase activity
HEP87_RS09535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP87_RS09535	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP87_RS09560	COG0577	efflux transmembrane transporter activity
HEP87_RS09560	COG1136	(ABC) transporter
HEP87_RS09570	COG2197	response regulator
HEP87_RS09595	COG0714	Associated with various cellular activities
HEP87_RS09630	COG0596	Alpha beta hydrolase
HEP87_RS09635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP87_RS09635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEP87_RS09640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP87_RS09645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEP87_RS09655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP87_RS09675	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HEP87_RS09705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP87_RS09715	COG2080	2 iron, 2 sulfur cluster binding
HEP87_RS09730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP87_RS09740	COG2770	Histidine kinase
HEP87_RS09740	COG2208	phosphoserine phosphatase activity
HEP87_RS09760	COG0745	RESPONSE REGULATOR receiver
HEP87_RS09875	COG4221	oxidoreductase activity
HEP87_RS09900	COG0513	Belongs to the DEAD box helicase family
HEP87_RS09935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP87_RS09945	COG1618	nucleotide phosphatase activity, acting on free nucleotides
HEP87_RS09955	COG0432	Pfam Uncharacterised protein family UPF0047
HEP87_RS09960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP87_RS09965	COG1116	anion transmembrane transporter activity
HEP87_RS09975	COG2072	flavoprotein involved in K transport
HEP87_RS09985	COG1132	(ABC) transporter
HEP87_RS09995	COG1301	dicarboxylic acid transport
HEP87_RS10015	COG1132	(ABC) transporter
HEP87_RS10025	COG0254	rRNA binding
HEP87_RS10040	COG1946	Acyl-CoA thioesterase
HEP87_RS10050	COG2018	Roadblock/LC7 domain
HEP87_RS10115	COG3239	Fatty acid desaturase
HEP87_RS10120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEP87_RS10140	COG2115	Belongs to the xylose isomerase family
HEP87_RS10150	COG1846	Transcriptional regulator
HEP87_RS10150	COG1940	carbohydrate kinase activity
HEP87_RS10155	COG1113	amino acid transport
HEP87_RS10175	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS10220	COG0515	serine threonine protein kinase
HEP87_RS10250	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS10255	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS10270	COG0492	ferredoxin-NADP+ reductase activity
HEP87_RS10275	COG1793	dna ligase
HEP87_RS10285	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS10300	COG3424	synthase
HEP87_RS10305	COG2124	cytochrome p450
HEP87_RS10315	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS10325	COG0242	peptide deformylase activity
HEP87_RS10335	COG3442	glutamine amidotransferase
HEP87_RS10340	COG0205	6-phosphofructokinase activity
HEP87_RS10370	COG3275	phosphorelay sensor kinase activity
HEP87_RS10385	COG3279	Response regulator of the LytR AlgR family
HEP87_RS10400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP87_RS10410	COG1510	regulation of RNA biosynthetic process
HEP87_RS10420	COG1733	regulation of RNA biosynthetic process
HEP87_RS10435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HEP87_RS10465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEP87_RS10475	COG0804	urea catabolic process
HEP87_RS10480	COG0832	Belongs to the urease beta subunit family
HEP87_RS10485	COG0831	urea catabolic process
HEP87_RS10495	COG0740	serine-type endopeptidase activity
HEP87_RS10530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP87_RS10535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP87_RS10585	COG0456	acetyltransferase
HEP87_RS10605	COG0069	glutamate synthase activity
HEP87_RS10660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEP87_RS10665	COG3663	DNA glycosylase
HEP87_RS10685	COG4585	Histidine kinase
HEP87_RS10690	COG2197	response regulator
HEP87_RS10695	COG1940	carbohydrate kinase activity
HEP87_RS10700	COG2188	Transcriptional regulator
HEP87_RS10705	COG1595	DNA-templated transcription, initiation
HEP87_RS10735	COG0626	cystathionine gamma-synthase activity
HEP87_RS10755	COG0583	DNA-binding transcription factor activity
HEP87_RS10765	COG1522	sequence-specific DNA binding
HEP87_RS10775	COG0420	3'-5' exonuclease activity
HEP87_RS10780	COG1739	Uncharacterized protein family UPF0029
HEP87_RS10800	COG2197	response regulator
HEP87_RS10825	COG0667	Aldo Keto reductase
HEP87_RS10830	COG1832	CoA-binding protein
HEP87_RS10865	COG2326	polyphosphate kinase activity
HEP87_RS10870	COG0640	Transcriptional regulator
HEP87_RS10895	COG0110	maltose O-acetyltransferase activity
HEP87_RS10930	COG1609	Transcriptional regulator
HEP87_RS10995	COG3835	regulator
HEP87_RS11000	COG2010	Cytochrome c
HEP87_RS11000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP87_RS11005	COG2080	2 iron, 2 sulfur cluster binding
HEP87_RS11010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HEP87_RS11010	COG3608	succinylglutamate desuccinylase aspartoacylase
HEP87_RS11040	COG4249	Peptidase C14 caspase catalytic subunit p20
HEP87_RS11040	COG2319	Wd-40 repeat
HEP87_RS11085	COG0791	NLP P60 protein
HEP87_RS11150	COG2255	four-way junction helicase activity
HEP87_RS11245	COG2815	serine threonine protein kinase
HEP87_RS11245	COG0515	serine threonine protein kinase
HEP87_RS11310	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HEP87_RS11325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEP87_RS11330	COG0655	NAD(P)H dehydrogenase (quinone) activity
HEP87_RS11340	COG0515	serine threonine protein kinase
HEP87_RS11340	COG2815	serine threonine protein kinase
HEP87_RS11345	COG1111	helicase
HEP87_RS11345	COG1205	dead DEAH box helicase
HEP87_RS11350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEP87_RS11355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HEP87_RS11410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP87_RS11460	COG1674	ftsk spoiiie
HEP87_RS11635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP87_RS11650	COG0183	Belongs to the thiolase family
HEP87_RS11675	COG1968	undecaprenyl-diphosphatase activity
HEP87_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS11710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS11720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HEP87_RS11730	COG2318	DinB family
HEP87_RS11740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP87_RS11745	COG0747	negative chemotaxis
HEP87_RS11790	COG0697	spore germination
HEP87_RS11830	COG1695	Transcriptional regulator
HEP87_RS11865	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP87_RS11865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP87_RS11875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP87_RS11895	COG1716	ATPase activity
HEP87_RS11915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP87_RS11945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP87_RS11960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP87_RS11965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP87_RS11975	COG2816	NAD+ diphosphatase activity
HEP87_RS11980	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEP87_RS11990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP87_RS12000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP87_RS12005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP87_RS12025	COG2018	Roadblock/LC7 domain
HEP87_RS12070	COG2814	Major facilitator Superfamily
HEP87_RS12075	COG4336	lyase activity
HEP87_RS12080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HEP87_RS12090	COG1984	allophanate hydrolase subunit 2
HEP87_RS12095	COG2755	lipolytic protein G-D-S-L family
HEP87_RS12100	COG0438	transferase activity, transferring glycosyl groups
HEP87_RS12105	COG0438	transferase activity, transferring glycosyl groups
HEP87_RS12130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP87_RS12145	COG2270	Major facilitator Superfamily
HEP87_RS12160	COG0463	Glycosyl transferase, family 2
HEP87_RS12165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP87_RS12190	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS12200	COG1309	transcriptional regulator
HEP87_RS12245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP87_RS12250	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP87_RS12255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP87_RS12260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP87_RS12260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP87_RS12265	COG3201	nicotinamide mononucleotide transporter
HEP87_RS12280	COG2223	nitrite transmembrane transporter activity
HEP87_RS12295	COG2233	PERMEase
HEP87_RS12310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS12320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP87_RS12340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP87_RS12345	COG3842	ATPase activity
HEP87_RS12365	COG2188	Transcriptional regulator
HEP87_RS12375	COG0531	amino acid
HEP87_RS12395	COG2390	Transcriptional regulator
HEP87_RS12400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEP87_RS12410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP87_RS12425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEP87_RS12440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP87_RS12455	COG0194	GDP metabolic process
HEP87_RS12465	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP87_RS12470	COG0167	dihydroorotate dehydrogenase activity
HEP87_RS12475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP87_RS12480	COG0505	Belongs to the CarA family
HEP87_RS12490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP87_RS12495	COG0540	Belongs to the ATCase OTCase family
HEP87_RS12500	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HEP87_RS12510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP87_RS12515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP87_RS12535	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP87_RS12540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEP87_RS12550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP87_RS12555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP87_RS12560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP87_RS12580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP87_RS12595	COG1131	(ABC) transporter
HEP87_RS12605	COG4585	Histidine kinase
HEP87_RS12610	COG2197	response regulator
HEP87_RS12615	COG0124	histidyl-tRNA synthetase
HEP87_RS12625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP87_RS12630	COG1196	nuclear chromosome segregation
HEP87_RS12645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HEP87_RS12650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP87_RS12655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP87_RS12665	COG2255	four-way junction helicase activity
HEP87_RS12670	COG0632	four-way junction helicase activity
HEP87_RS12675	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HEP87_RS12680	COG0217	transcriptional regulatory protein
HEP87_RS12685	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HEP87_RS12690	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HEP87_RS12700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP87_RS12705	COG0438	transferase activity, transferring glycosyl groups
HEP87_RS12715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP87_RS12735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP87_RS12740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEP87_RS12755	COG5002	protein histidine kinase activity
HEP87_RS12755	COG2176	DNA-directed DNA polymerase activity
HEP87_RS12785	COG0395	ABC-type sugar transport system, permease component
HEP87_RS12790	COG1175	transmembrane transport
HEP87_RS12845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP87_RS12910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HEP87_RS12925	COG1464	Belongs to the NlpA lipoprotein family
HEP87_RS12930	COG2011	ABC-type metal ion transport system permease component
HEP87_RS12935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP87_RS12975	COG0204	Acyl-transferase
HEP87_RS12975	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS12995	COG0165	Argininosuccinate lyase
HEP87_RS13000	COG0137	argininosuccinate synthase activity
HEP87_RS13025	COG0745	RESPONSE REGULATOR receiver
HEP87_RS13055	COG1438	arginine binding
HEP87_RS13060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP87_RS13065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP87_RS13070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEP87_RS13075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP87_RS13100	COG0789	Transcriptional regulator
HEP87_RS13150	COG0697	spore germination
HEP87_RS13160	COG1649	PFAM Uncharacterised BCR, COG1649
HEP87_RS13185	COG0515	serine threonine protein kinase
HEP87_RS13210	COG0072	phenylalanine-tRNA ligase activity
HEP87_RS13210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP87_RS13215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP87_RS13220	COG5002	protein histidine kinase activity
HEP87_RS13225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP87_RS13230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP87_RS13235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HEP87_RS13240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP87_RS13325	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS13345	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS13350	COG0174	glutamine synthetase
HEP87_RS13380	COG1733	regulation of RNA biosynthetic process
HEP87_RS13385	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS13400	COG0667	Aldo Keto reductase
HEP87_RS13420	COG4176	ABC-type proline glycine betaine transport system permease component
HEP87_RS13425	COG0517	IMP dehydrogenase activity
HEP87_RS13425	COG4175	Glycine betaine
HEP87_RS13430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP87_RS13460	COG0564	pseudouridine synthase activity
HEP87_RS13490	COG1309	transcriptional regulator
HEP87_RS13530	COG0805	protein transport
HEP87_RS13535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP87_RS13565	COG0545	Peptidyl-prolyl cis-trans isomerase
HEP87_RS13570	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP87_RS13580	COG1609	Transcriptional regulator
HEP87_RS13585	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP87_RS13590	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP87_RS13605	COG4122	O-methyltransferase activity
HEP87_RS13610	COG1222	aaa ATPase
HEP87_RS13635	COG1994	Peptidase M50
HEP87_RS13635	COG0517	IMP dehydrogenase activity
HEP87_RS13645	COG2197	response regulator
HEP87_RS13655	COG4166	transmembrane transport
HEP87_RS13665	COG0646	methionine synthase
HEP87_RS13665	COG1410	methionine synthase
HEP87_RS13670	COG1414	Transcriptional regulator
HEP87_RS13675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP87_RS13680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP87_RS13685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEP87_RS13700	COG2186	Transcriptional regulator
HEP87_RS13725	COG0215	cysteine-tRNA ligase activity
HEP87_RS13745	COG0598	Magnesium transport protein CorA
HEP87_RS13755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS13760	COG0667	Aldo Keto reductase
HEP87_RS13790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP87_RS13805	COG0308	aminopeptidase N
HEP87_RS13810	COG3012	SEC-C Motif Domain Protein
HEP87_RS13815	COG2186	Transcriptional regulator
HEP87_RS13820	COG3265	gluconokinase activity
HEP87_RS13830	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS13860	COG3573	Dehydrogenase
HEP87_RS13870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP87_RS13875	COG2149	membrane
HEP87_RS13905	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS13915	COG3876	Protein conserved in bacteria
HEP87_RS13935	COG0072	phenylalanine-tRNA ligase activity
HEP87_RS13935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP87_RS13940	COG0789	Transcriptional regulator
HEP87_RS13960	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS13970	COG0640	Transcriptional regulator
HEP87_RS13975	COG0697	spore germination
HEP87_RS14000	COG2851	Citrate transporter
HEP87_RS14005	COG0243	molybdopterin cofactor binding
HEP87_RS14010	COG1309	transcriptional regulator
HEP87_RS14020	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP87_RS14025	COG2188	Transcriptional regulator
HEP87_RS14065	COG1595	DNA-templated transcription, initiation
HEP87_RS14085	COG2815	serine threonine protein kinase
HEP87_RS14085	COG0515	serine threonine protein kinase
HEP87_RS14090	COG2755	lipolytic protein G-D-S-L family
HEP87_RS14115	COG1649	PFAM Uncharacterised BCR, COG1649
HEP87_RS14115	COG0726	polysaccharide deacetylase
HEP87_RS14140	COG1725	Transcriptional regulator
HEP87_RS14155	COG2226	methyltransferase
HEP87_RS14180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEP87_RS14180	COG0662	Cupin 2, conserved barrel domain protein
HEP87_RS14185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP87_RS14190	COG0587	DNA-directed DNA polymerase activity
HEP87_RS14200	COG0330	HflC and HflK could
HEP87_RS14215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS14220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS14225	COG1126	abc transporter atp-binding protein
HEP87_RS14235	COG0765	amino acid transport
HEP87_RS14250	COG1799	cell septum assembly
HEP87_RS14255	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS14260	COG0477	Major facilitator Superfamily
HEP87_RS14270	COG0671	phosphoesterase, PA-phosphatase related
HEP87_RS14280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP87_RS14320	COG3583	domain protein
HEP87_RS14340	COG1160	GTP binding
HEP87_RS14350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP87_RS14390	COG3541	Predicted nucleotidyltransferase
HEP87_RS14405	COG1187	pseudouridine synthase activity
HEP87_RS14410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP87_RS14430	COG0686	Belongs to the AlaDH PNT family
HEP87_RS14440	COG0494	nUDIX hydrolase
HEP87_RS14445	COG0504	CTP synthase activity
HEP87_RS14450	COG3387	PFAM Glycoside hydrolase 15-related
HEP87_RS14465	COG0438	transferase activity, transferring glycosyl groups
HEP87_RS14470	COG0497	DNA recombination
HEP87_RS14475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEP87_RS14495	COG1120	ATPase activity
HEP87_RS14500	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP87_RS14505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP87_RS14510	COG0647	UMP catabolic process
HEP87_RS14540	COG2094	Belongs to the DNA glycosylase MPG family
HEP87_RS14550	COG1881	PFAM PEBP family protein
HEP87_RS14570	COG1119	ATPase activity
HEP87_RS14585	COG2197	response regulator
HEP87_RS14600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP87_RS14610	COG0842	Transport permease protein
HEP87_RS14610	COG1716	ATPase activity
HEP87_RS14610	COG1131	(ABC) transporter
HEP87_RS14620	COG3830	Belongs to the UPF0237 family
HEP87_RS14620	COG0560	Phosphoserine phosphatase
HEP87_RS14625	COG0588	phosphoglycerate mutase activity
HEP87_RS14640	COG2186	Transcriptional regulator
HEP87_RS14655	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS14670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP87_RS14690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP87_RS14695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP87_RS14765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP87_RS14795	COG0515	serine threonine protein kinase
HEP87_RS14795	COG2815	serine threonine protein kinase
HEP87_RS14820	COG3387	PFAM Glycoside hydrolase 15-related
HEP87_RS14870	COG0488	(ABC) transporter
HEP87_RS14900	COG0235	Class ii aldolase
HEP87_RS14925	COG1492	cobalamin metabolic process
HEP87_RS14940	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HEP87_RS14945	COG1797	cobyrinic acid a,c-diamide synthase activity
HEP87_RS14980	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HEP87_RS15000	COG1126	abc transporter atp-binding protein
HEP87_RS15005	COG0765	amino acid transport
HEP87_RS15015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEP87_RS15025	COG0456	acetyltransferase
HEP87_RS15030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP87_RS15035	COG1917	Cupin 2, conserved barrel domain protein
HEP87_RS15040	COG5285	phytanoyl-CoA dioxygenase
HEP87_RS15070	COG1414	Transcriptional regulator
HEP87_RS15080	COG0768	penicillin binding
HEP87_RS15085	COG2252	PERMEase
HEP87_RS15090	COG1595	DNA-templated transcription, initiation
HEP87_RS15105	COG4733	cellulase activity
HEP87_RS15150	COG4677	pectinesterase activity
HEP87_RS15155	COG3866	Pectate lyase
HEP87_RS15160	COG2755	lipolytic protein G-D-S-L family
HEP87_RS15165	COG1653	transport
HEP87_RS15185	COG0395	ABC-type sugar transport system, permease component
HEP87_RS15200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP87_RS15205	COG1802	Transcriptional regulator
HEP87_RS15225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP87_RS15230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP87_RS15235	COG1349	DNA-binding transcription factor activity
HEP87_RS15250	COG0395	ABC-type sugar transport system, permease component
HEP87_RS15255	COG1063	alcohol dehydrogenase
HEP87_RS15265	COG1309	transcriptional regulator
HEP87_RS15280	COG1802	Transcriptional regulator
HEP87_RS15325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP87_RS15335	COG1595	DNA-templated transcription, initiation
HEP87_RS15345	COG3973	AAA domain
HEP87_RS15350	COG1063	alcohol dehydrogenase
HEP87_RS15355	COG2171	N-acyltransferase activity
HEP87_RS15360	COG3226	Transcriptional regulator
HEP87_RS15365	COG2076	Multidrug Resistance protein
HEP87_RS15385	COG0822	iron-sulfur transferase activity
HEP87_RS15390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP87_RS15395	COG0396	ATPase activity
HEP87_RS15405	COG0719	Fe-S assembly protein
HEP87_RS15420	COG2746	aminoglycoside 3-N-acetyltransferase activity
HEP87_RS15425	COG1131	(ABC) transporter
HEP87_RS15450	COG0109	protoheme IX farnesyltransferase activity
HEP87_RS15460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP87_RS15480	COG0395	ABC-type sugar transport system, permease component
HEP87_RS15500	COG1653	transport
HEP87_RS15505	COG1695	Transcriptional regulator
HEP87_RS15510	COG1136	(ABC) transporter
HEP87_RS15525	COG0166	Belongs to the GPI family
HEP87_RS15530	COG2814	Major facilitator Superfamily
HEP87_RS15540	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEP87_RS15545	COG0149	triose-phosphate isomerase activity
HEP87_RS15550	COG0126	phosphoglycerate kinase activity
HEP87_RS15555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP87_RS15565	COG1481	regulation of sporulation
HEP87_RS15570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEP87_RS15575	COG1660	Displays ATPase and GTPase activities
HEP87_RS15580	COG0322	excinuclease ABC activity
HEP87_RS15595	COG1609	Transcriptional regulator
HEP87_RS15605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP87_RS15620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP87_RS15625	COG0765	amino acid transport
HEP87_RS15635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP87_RS15640	COG0477	Major facilitator Superfamily
HEP87_RS15645	COG0387	Pfam Sodium calcium exchanger
HEP87_RS15665	COG0556	nucleotide-excision repair
HEP87_RS15675	COG0584	glycerophosphoryl diester phosphodiesterase
HEP87_RS15680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP87_RS15700	COG2313	pseudouridylate synthase activity
HEP87_RS15710	COG2226	methyltransferase
HEP87_RS15715	COG0598	Magnesium transport protein CorA
HEP87_RS15745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP87_RS15750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP87_RS15795	COG0402	S-adenosylhomocysteine deaminase activity
HEP87_RS15830	COG1802	Transcriptional regulator
HEP87_RS15835	COG2267	carboxylic ester hydrolase activity
HEP87_RS15845	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HEP87_RS15875	COG0237	dephospho-CoA kinase activity
HEP87_RS15895	COG2226	methyltransferase
HEP87_RS15940	COG2050	protein possibly involved in aromatic compounds catabolism
HEP87_RS16000	COG0737	Belongs to the 5'-nucleotidase family
HEP87_RS16020	COG0745	RESPONSE REGULATOR receiver
HEP87_RS16025	COG1605	Chorismate mutase
HEP87_RS16025	COG0287	Prephenate dehydrogenase
HEP87_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS16065	COG1024	Enoyl-CoA hydratase
HEP87_RS16085	COG0183	Belongs to the thiolase family
HEP87_RS16090	COG1309	transcriptional regulator
HEP87_RS16100	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS16105	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS16110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP87_RS16120	COG2304	oxidoreductase activity
HEP87_RS16135	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEP87_RS16135	COG1136	(ABC) transporter
HEP87_RS16190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP87_RS16195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP87_RS16200	COG2301	Belongs to the HpcH HpaI aldolase family
HEP87_RS16215	COG0159	tryptophan synthase activity
HEP87_RS16220	COG0133	tryptophan synthase activity
HEP87_RS16230	COG0134	indole-3-glycerol-phosphate synthase activity
HEP87_RS16255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP87_RS16275	COG0107	imidazoleglycerol-phosphate synthase activity
HEP87_RS16280	COG0251	oxidation-reduction process
HEP87_RS16285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HEP87_RS16290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP87_RS16300	COG0131	Imidazoleglycerol-phosphate dehydratase
HEP87_RS16305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP87_RS16310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP87_RS16330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEP87_RS16355	COG1432	Conserved Protein
HEP87_RS16365	COG0587	DNA-directed DNA polymerase activity
HEP87_RS16410	COG2153	protein acetylation
HEP87_RS16420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEP87_RS16435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HEP87_RS16440	COG3599	regulation of cell shape
HEP87_RS16450	COG1799	cell septum assembly
HEP87_RS16465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP87_RS16475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP87_RS16485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEP87_RS16490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP87_RS16500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEP87_RS16505	COG0768	penicillin binding
HEP87_RS16515	COG0275	rRNA processing
HEP87_RS16525	COG0714	Associated with various cellular activities
HEP87_RS16545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP87_RS16565	COG1309	transcriptional regulator
HEP87_RS16590	COG0352	thiamine-phosphate diphosphorylase activity
HEP87_RS16605	COG2022	thiamine diphosphate biosynthetic process
HEP87_RS16605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP87_RS16615	COG2022	thiamine diphosphate biosynthetic process
HEP87_RS16620	COG0515	serine threonine protein kinase
HEP87_RS16620	COG2815	serine threonine protein kinase
HEP87_RS16625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HEP87_RS16630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP87_RS16635	COG2193	ferroxidase activity
HEP87_RS16640	COG0243	molybdopterin cofactor binding
HEP87_RS16645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP87_RS16665	COG0205	6-phosphofructokinase activity
HEP87_RS16670	COG2197	response regulator
HEP87_RS16675	COG4585	Histidine kinase
HEP87_RS16745	COG0534	Mate efflux family protein
HEP87_RS16765	COG0791	NLP P60 protein
HEP87_RS16765	COG1388	LysM domain
HEP87_RS16765	COG3103	Sh3 type 3 domain protein
HEP87_RS16790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP87_RS16795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP87_RS16800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP87_RS16805	COG0723	plastoquinol--plastocyanin reductase activity
HEP87_RS16810	COG2010	Cytochrome c
HEP87_RS16815	COG1845	cytochrome c oxidase, subunit III
HEP87_RS16825	COG1376	ErfK ybiS ycfS ynhG family protein
HEP87_RS16835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP87_RS16840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP87_RS16850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP87_RS16870	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HEP87_RS16875	COG2197	response regulator
HEP87_RS16900	COG2226	methyltransferase
HEP87_RS16905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP87_RS16930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP87_RS16930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP87_RS16950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP87_RS16955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP87_RS17025	COG0321	lipoyl(octanoyl) transferase activity
HEP87_RS17030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP87_RS17050	COG0174	glutamine synthetase
HEP87_RS17060	COG0501	Belongs to the peptidase M48B family
HEP87_RS17115	COG0745	RESPONSE REGULATOR receiver
HEP87_RS17130	COG2197	response regulator
HEP87_RS17160	COG1309	transcriptional regulator
HEP87_RS17205	COG1175	transmembrane transport
HEP87_RS17210	COG3833	ABC-type maltose transport systems, permease component
HEP87_RS17215	COG0366	Alpha amylase catalytic
HEP87_RS17220	COG1609	Transcriptional regulator
HEP87_RS17235	COG0531	amino acid
HEP87_RS17245	COG0583	DNA-binding transcription factor activity
HEP87_RS17250	COG0697	spore germination
HEP87_RS17255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP87_RS17260	COG3511	phospholipase C
HEP87_RS17320	COG3903	Transcriptional regulator
HEP87_RS17320	COG3629	intracellular signal transduction
HEP87_RS17345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEP87_RS17350	COG2188	Transcriptional regulator
HEP87_RS17355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HEP87_RS17360	COG0174	glutamine synthetase
HEP87_RS17365	COG1017	nitric oxide dioxygenase activity
HEP87_RS17365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP87_RS17370	COG1959	2 iron, 2 sulfur cluster binding
HEP87_RS17390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP87_RS17390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP87_RS17395	COG2814	Major facilitator Superfamily
HEP87_RS17410	COG0477	Major facilitator Superfamily
HEP87_RS17415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP87_RS17435	COG1994	Peptidase M50
HEP87_RS17485	COG2822	iron ion transport
HEP87_RS17490	COG2837	iron assimilation
HEP87_RS17495	COG0672	)-iron permease
HEP87_RS17505	COG0495	leucyl-tRNA aminoacylation
HEP87_RS17515	COG1834	amidinotransferase
HEP87_RS17525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP87_RS17530	COG2814	Major facilitator Superfamily
HEP87_RS17555	COG1136	(ABC) transporter
HEP87_RS17565	COG2259	Doxx family
HEP87_RS17580	COG0406	alpha-ribazole phosphatase activity
HEP87_RS17585	COG1609	Transcriptional regulator
HEP87_RS17590	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS17595	COG0673	inositol 2-dehydrogenase activity
HEP87_RS17665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP87_RS17675	COG2197	response regulator
HEP87_RS17685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP87_RS17725	COG0583	DNA-binding transcription factor activity
HEP87_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS17770	COG1309	transcriptional regulator
HEP87_RS17805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP87_RS17835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP87_RS17910	COG3022	response to hydroperoxide
HEP87_RS17915	COG0800	Aldolase
HEP87_RS17940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HEP87_RS17965	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS17975	COG2030	dehydratase
HEP87_RS17980	COG1131	(ABC) transporter
HEP87_RS18000	COG2197	response regulator
HEP87_RS18020	COG0183	Belongs to the thiolase family
HEP87_RS18025	COG0477	Major facilitator Superfamily
HEP87_RS18035	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP87_RS18045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS18075	COG1309	transcriptional regulator
HEP87_RS18150	COG3619	membrane
HEP87_RS18185	COG0183	Belongs to the thiolase family
HEP87_RS18190	COG2124	cytochrome p450
HEP87_RS18210	COG4122	O-methyltransferase activity
HEP87_RS18290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEP87_RS18295	COG1335	isochorismatase
HEP87_RS18300	COG0477	Major facilitator Superfamily
HEP87_RS18320	COG1733	regulation of RNA biosynthetic process
HEP87_RS18440	COG0515	serine threonine protein kinase
HEP87_RS18440	COG2815	serine threonine protein kinase
HEP87_RS18500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP87_RS18515	COG1358	cellular component organization or biogenesis
HEP87_RS18560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEP87_RS18565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP87_RS18570	COG0477	Major facilitator Superfamily
HEP87_RS18575	COG1309	transcriptional regulator
HEP87_RS18590	COG0667	Aldo Keto reductase
HEP87_RS18595	COG0789	Transcriptional regulator
HEP87_RS18610	COG1741	Belongs to the pirin family
HEP87_RS18625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP87_RS18630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP87_RS18665	COG1309	transcriptional regulator
HEP87_RS18680	COG2084	Dehydrogenase
HEP87_RS18710	COG1764	response to oxidative stress
HEP87_RS18715	COG2130	NADP-dependent
HEP87_RS18730	COG4948	Mandelate Racemase Muconate Lactonizing
HEP87_RS18755	COG4214	carbohydrate transport
HEP87_RS18765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP87_RS18800	COG1764	response to oxidative stress
HEP87_RS18830	COG0596	Alpha beta hydrolase
HEP87_RS18850	COG2318	DinB family
HEP87_RS18875	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP87_RS18880	COG0395	ABC-type sugar transport system, permease component
HEP87_RS18885	COG1175	transmembrane transport
HEP87_RS18895	COG3386	PFAM SMP-30 Gluconolaconase
HEP87_RS18900	COG1414	Transcriptional regulator
HEP87_RS19030	COG1404	Belongs to the peptidase S8 family
HEP87_RS19035	COG1077	Cell shape determining protein MreB Mrl
HEP87_RS19090	COG1070	Carbohydrate kinase
HEP87_RS19105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP87_RS19110	COG0358	DNA primase activity
HEP87_RS19120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HEP87_RS19130	COG2949	membrane
HEP87_RS19180	COG2146	nitrite reductase [NAD(P)H] activity
HEP87_RS19180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP87_RS19190	COG1309	transcriptional regulator
HEP87_RS19195	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS19200	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS19210	COG1136	(ABC) transporter
HEP87_RS19220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP87_RS19220	COG0574	Belongs to the PEP-utilizing enzyme family
HEP87_RS19225	COG1846	Transcriptional regulator
HEP87_RS19225	COG1940	carbohydrate kinase activity
HEP87_RS19255	COG0477	Major facilitator Superfamily
HEP87_RS19265	COG1595	DNA-templated transcription, initiation
HEP87_RS19300	COG0667	Aldo Keto reductase
HEP87_RS19310	COG1309	transcriptional regulator
HEP87_RS19315	COG0300	oxidoreductase activity
HEP87_RS19320	COG0423	glycine-tRNA ligase activity
HEP87_RS19325	COG0803	Belongs to the bacterial solute-binding protein 9 family
HEP87_RS19330	COG1121	(ABC) transporter
HEP87_RS19335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEP87_RS19350	COG1381	Involved in DNA repair and RecF pathway recombination
HEP87_RS19380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP87_RS19380	COG0515	serine threonine protein kinase
HEP87_RS19385	COG2197	response regulator
HEP87_RS19390	COG4585	Histidine kinase
HEP87_RS19405	COG2186	Transcriptional regulator
HEP87_RS19410	COG0747	negative chemotaxis
HEP87_RS19420	COG0444	Belongs to the ABC transporter superfamily
HEP87_RS19425	COG4608	Belongs to the ABC transporter superfamily
HEP87_RS19430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP87_RS19445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP87_RS19465	COG2723	6-phospho-beta-galactosidase activity
HEP87_RS19505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP87_RS19525	COG2315	Protein conserved in bacteria
HEP87_RS19535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEP87_RS19555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP87_RS19560	COG1234	tRNA 3'-trailer cleavage
HEP87_RS19565	COG0537	adenosine 5'-monophosphoramidase activity
HEP87_RS19595	COG0484	heat shock protein binding
HEP87_RS19600	COG1420	regulation of RNA biosynthetic process
HEP87_RS19640	COG0481	GTPase activity
HEP87_RS19650	COG0268	Binds directly to 16S ribosomal RNA
HEP87_RS19805	COG1061	Type III restriction enzyme res subunit
HEP87_RS19850	COG1307	EDD domain protein, DegV family
HEP87_RS19860	COG0495	leucyl-tRNA aminoacylation
HEP87_RS19895	COG0477	Major facilitator Superfamily
HEP87_RS19910	COG0588	phosphoglycerate mutase activity
HEP87_RS19915	COG0799	negative regulation of ribosome biogenesis
HEP87_RS19925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP87_RS19940	COG0501	Belongs to the peptidase M48B family
HEP87_RS19955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP87_RS19965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HEP87_RS19995	COG3540	Alkaline phosphatase
HEP87_RS20000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP87_RS20005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP87_RS20010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP87_RS20045	COG1309	transcriptional regulator
HEP87_RS20050	COG4221	oxidoreductase activity
HEP87_RS20090	COG0772	Belongs to the SEDS family
HEP87_RS20095	COG0768	penicillin binding
HEP87_RS20110	COG1077	Cell shape determining protein MreB Mrl
HEP87_RS20115	COG0105	UTP biosynthetic process
HEP87_RS20125	COG0285	dihydrofolate synthase activity
HEP87_RS20130	COG0525	valine-tRNA ligase activity
HEP87_RS20140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP87_RS20145	COG0740	serine-type endopeptidase activity
HEP87_RS20150	COG0740	serine-type endopeptidase activity
HEP87_RS20155	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP87_RS20175	COG3594	Acyltransferase
HEP87_RS20190	COG4552	Acetyltransferase involved in intracellular survival and related
HEP87_RS20220	COG1268	BioY protein
HEP87_RS20225	COG1940	carbohydrate kinase activity
HEP87_RS20235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP87_RS20240	COG1116	anion transmembrane transporter activity
HEP87_RS20245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS20255	COG1113	amino acid transport
HEP87_RS20260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEP87_RS20265	COG0588	phosphoglycerate mutase activity
HEP87_RS20275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEP87_RS20355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEP87_RS20375	COG0697	spore germination
HEP87_RS20390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP87_RS20420	COG1136	(ABC) transporter
HEP87_RS20435	COG0668	transmembrane transport
HEP87_RS20490	COG1175	transmembrane transport
HEP87_RS20495	COG0395	ABC-type sugar transport system, permease component
HEP87_RS20500	COG1486	melibiose metabolic process
HEP87_RS20515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP87_RS20545	COG2346	COG2346, Truncated hemoglobins
HEP87_RS20580	COG0577	efflux transmembrane transporter activity
HEP87_RS20595	COG2197	response regulator
HEP87_RS20600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP87_RS20605	COG0489	protein tyrosine kinase activity
HEP87_RS20625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEP87_RS20645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEP87_RS20750	COG0629	single-stranded DNA binding
HEP87_RS20855	COG3962	Belongs to the TPP enzyme family
HEP87_RS20860	COG3718	enzyme involved in inositol metabolism
HEP87_RS20870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP87_RS20925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP87_RS20940	COG1129	ABC transporter
HEP87_RS20950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP87_RS20955	COG1869	D-ribose catabolic process
HEP87_RS20975	COG0673	inositol 2-dehydrogenase activity
HEP87_RS21005	COG0181	hydroxymethylbilane synthase activity
HEP87_RS21010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HEP87_RS21015	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP87_RS21090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP87_RS21095	COG2356	endonuclease I
HEP87_RS21105	COG0028	Belongs to the TPP enzyme family
HEP87_RS21115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP87_RS21140	COG1946	Acyl-CoA thioesterase
HEP87_RS21160	COG1309	transcriptional regulator
HEP87_RS21165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP87_RS21180	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS21215	COG0076	glutamate decarboxylase activity
HEP87_RS21220	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HEP87_RS21255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP87_RS21265	COG0589	response to stress
HEP87_RS21280	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP87_RS21315	COG0395	ABC-type sugar transport system, permease component
HEP87_RS21345	COG3979	chitinase
HEP87_RS21380	COG0406	alpha-ribazole phosphatase activity
HEP87_RS21430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS21445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP87_RS21460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP87_RS21465	COG0765	amino acid transport
HEP87_RS21470	COG0765	amino acid transport
HEP87_RS21475	COG1126	abc transporter atp-binding protein
HEP87_RS21490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP87_RS21505	COG1362	aminopeptidase activity
HEP87_RS21525	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS21535	COG3397	chitin binding
HEP87_RS21585	COG2188	Transcriptional regulator
HEP87_RS21615	COG0673	inositol 2-dehydrogenase activity
HEP87_RS21620	COG4702	Belongs to the UPF0303 family
HEP87_RS21630	COG0706	membrane insertase activity
HEP87_RS21630	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
HEP87_RS21650	COG3764	Sortase (surface protein transpeptidase)
HEP87_RS21660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEP87_RS21725	COG0590	tRNA wobble adenosine to inosine editing
HEP87_RS21735	COG1403	HNH endonuclease
HEP87_RS21745	COG3250	beta-galactosidase activity
HEP87_RS21760	COG1846	Transcriptional regulator
HEP87_RS21790	COG2733	membrane
HEP87_RS21805	COG4555	ABC transporter
HEP87_RS21855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP87_RS21865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP87_RS21870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEP87_RS21875	COG1263	PTS System
HEP87_RS21880	COG1263	PTS System
HEP87_RS21925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HEP87_RS21975	COG0667	Aldo Keto reductase
HEP87_RS21980	COG0277	FAD linked oxidase domain protein
HEP87_RS21990	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HEP87_RS22020	COG3480	Lon protease (S16) C-terminal proteolytic domain
HEP87_RS22025	COG4948	Mandelate Racemase Muconate Lactonizing
HEP87_RS22045	COG0531	amino acid
HEP87_RS22095	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP87_RS22100	COG0395	ABC-type sugar transport system, permease component
HEP87_RS22105	COG1175	transmembrane transport
HEP87_RS22110	COG1653	transport
HEP87_RS22120	COG1678	Uncharacterized ACR, COG1678
HEP87_RS22125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEP87_RS22130	COG0776	regulation of translation
HEP87_RS22140	COG3973	AAA domain
HEP87_RS22170	COG2223	nitrite transmembrane transporter activity
HEP87_RS22200	COG0583	DNA-binding transcription factor activity
HEP87_RS22215	COG1175	transmembrane transport
HEP87_RS22220	COG0395	ABC-type sugar transport system, permease component
HEP87_RS22225	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP87_RS22230	COG1609	Transcriptional regulator
HEP87_RS22280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP87_RS22285	COG0793	Belongs to the peptidase S41A family
HEP87_RS22295	COG2884	Cell division ATP-binding protein ftsE
HEP87_RS22310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP87_RS22345	COG0395	ABC-type sugar transport system, permease component
HEP87_RS22350	COG0463	Glycosyl transferase, family 2
HEP87_RS22350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP87_RS22355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP87_RS22360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP87_RS22375	COG1764	response to oxidative stress
HEP87_RS22380	COG1846	Transcriptional regulator
HEP87_RS22420	COG2197	response regulator
HEP87_RS22445	COG1134	teichoic acid transport
HEP87_RS22450	COG0438	transferase activity, transferring glycosyl groups
HEP87_RS22455	COG0463	Glycosyl transferase, family 2
HEP87_RS22455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP87_RS22465	COG2902	Dehydrogenase
HEP87_RS22490	COG0653	protein targeting
HEP87_RS22500	COG3214	Protein conserved in bacteria
HEP87_RS22505	COG2197	response regulator
HEP87_RS22510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEP87_RS22520	COG0823	Involved in the tonB-independent uptake of proteins
HEP87_RS22525	COG5000	phosphorelay sensor kinase activity
HEP87_RS22525	COG5002	protein histidine kinase activity
HEP87_RS22530	COG0745	RESPONSE REGULATOR receiver
HEP87_RS22535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEP87_RS22555	COG0714	Associated with various cellular activities
HEP87_RS22595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HEP87_RS22605	COG1482	cell wall glycoprotein biosynthetic process
HEP87_RS22615	COG2835	tetraacyldisaccharide 4'-kinase activity
HEP87_RS22620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP87_RS22625	COG1620	l-lactate permease
HEP87_RS22660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEP87_RS22665	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HEP87_RS22665	COG0778	Nitroreductase
HEP87_RS22710	COG1316	TRANSCRIPTIONal
HEP87_RS22715	COG1316	TRANSCRIPTIONal
HEP87_RS22725	COG1011	Hydrolase
HEP87_RS22735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEP87_RS22780	COG2205	protein histidine kinase activity
HEP87_RS22785	COG0745	RESPONSE REGULATOR receiver
HEP87_RS22790	COG3104	oligopeptide transport
HEP87_RS22865	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP87_RS22870	COG1191	sigma factor activity
HEP87_RS22880	COG1228	amidohydrolase
HEP87_RS22890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP87_RS22895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP87_RS22935	COG2986	histidine ammonia-lyase
HEP87_RS22945	COG1174	glycine betaine transport
HEP87_RS22950	COG1174	glycine betaine transport
HEP87_RS22960	COG1609	Transcriptional regulator
HEP87_RS22995	COG0183	Belongs to the thiolase family
HEP87_RS23030	COG1136	(ABC) transporter
HEP87_RS23030	COG0577	efflux transmembrane transporter activity
HEP87_RS23035	COG0577	efflux transmembrane transporter activity
HEP87_RS23040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP87_RS23045	COG1252	NADH dehydrogenase
HEP87_RS23060	COG0148	phosphopyruvate hydratase activity
HEP87_RS23075	COG2124	cytochrome p450
HEP87_RS23165	COG3209	COG3209 Rhs family protein
HEP87_RS23185	COG1309	transcriptional regulator
HEP87_RS23200	COG1136	(ABC) transporter
HEP87_RS23200	COG0577	efflux transmembrane transporter activity
HEP87_RS23205	COG1136	(ABC) transporter
HEP87_RS23210	COG0477	Major facilitator Superfamily
HEP87_RS23220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP87_RS23250	COG4585	Histidine kinase
HEP87_RS23265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP87_RS23270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP87_RS23275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HEP87_RS23280	COG0193	aminoacyl-tRNA hydrolase activity
HEP87_RS23290	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HEP87_RS23300	COG1309	transcriptional regulator
HEP87_RS23310	COG4106	trans-aconitate 2-methyltransferase activity
HEP87_RS23320	COG2197	response regulator
HEP87_RS23330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HEP87_RS23375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP87_RS23395	COG0488	(ABC) transporter
HEP87_RS23405	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEP87_RS23420	COG0084	hydrolase, TatD family'
HEP87_RS23450	COG0768	penicillin binding
HEP87_RS23460	COG0442	prolyl-tRNA aminoacylation
HEP87_RS23505	COG0310	cobalt ion transport
HEP87_RS23515	COG1122	ATPase activity
HEP87_RS23520	COG1846	Transcriptional regulator
HEP87_RS23525	COG1764	response to oxidative stress
HEP87_RS23540	COG2409	Drug exporters of the RND superfamily
HEP87_RS23550	COG4946	Tricorn protease homolog
HEP87_RS23550	COG0793	Belongs to the peptidase S41A family
HEP87_RS23560	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS23565	COG2267	carboxylic ester hydrolase activity
HEP87_RS23570	COG2072	flavoprotein involved in K transport
HEP87_RS23580	COG0708	Exodeoxyribonuclease III
HEP87_RS23600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP87_RS23605	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP87_RS23605	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP87_RS23610	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP87_RS23620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP87_RS23625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP87_RS23650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP87_RS23660	COG1970	mechanosensitive ion channel activity
HEP87_RS23680	COG1376	ErfK ybiS ycfS ynhG family protein
HEP87_RS23695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP87_RS23695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP87_RS23695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP87_RS23705	COG1349	DNA-binding transcription factor activity
HEP87_RS23735	COG0477	Major facilitator Superfamily
HEP87_RS23755	COG1247	-acetyltransferase
HEP87_RS23760	COG3384	dioxygenase
HEP87_RS23765	COG1846	Transcriptional regulator
HEP87_RS23785	COG1414	Transcriptional regulator
HEP87_RS23790	COG0477	Major facilitator Superfamily
HEP87_RS23815	COG4974	Belongs to the 'phage' integrase family
HEP87_RS23875	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HEP87_RS23885	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HEP87_RS24110	COG2197	response regulator
HEP87_RS24115	COG4585	Histidine kinase
HEP87_RS24175	COG2843	Capsule synthesis protein
HEP87_RS24180	COG2197	response regulator
HEP87_RS24235	COG0726	polysaccharide deacetylase
HEP87_RS24245	COG1725	Transcriptional regulator
HEP87_RS24290	COG1309	transcriptional regulator
HEP87_RS24310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP87_RS24325	COG2188	Transcriptional regulator
HEP87_RS24350	COG0386	Belongs to the glutathione peroxidase family
HEP87_RS24365	COG1686	Belongs to the peptidase S11 family
HEP87_RS24420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP87_RS24440	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS24445	COG2267	carboxylic ester hydrolase activity
HEP87_RS24465	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HEP87_RS24490	COG3629	intracellular signal transduction
HEP87_RS24490	COG3903	Transcriptional regulator
HEP87_RS24520	COG1024	Enoyl-CoA hydratase
HEP87_RS24535	COG1309	transcriptional regulator
HEP87_RS24580	COG0259	pyridoxamine-phosphate oxidase activity
HEP87_RS24585	COG0583	DNA-binding transcription factor activity
HEP87_RS24630	COG1024	Enoyl-CoA hydratase
HEP87_RS24640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP87_RS24660	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS24665	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS24680	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS24685	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS24695	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS24710	COG1595	DNA-templated transcription, initiation
HEP87_RS24760	COG2267	carboxylic ester hydrolase activity
HEP87_RS24770	COG4821	SIS domain
HEP87_RS24795	COG0259	pyridoxamine-phosphate oxidase activity
HEP87_RS24805	COG1024	Enoyl-CoA hydratase
HEP87_RS24810	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS24825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP87_RS24890	COG1132	(ABC) transporter
HEP87_RS24895	COG0277	FAD linked oxidase domain protein
HEP87_RS24895	COG0247	lactate metabolic process
HEP87_RS24920	COG2124	cytochrome p450
HEP87_RS24930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP87_RS24935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP87_RS24960	COG0667	Aldo Keto reductase
HEP87_RS24980	COG1846	Transcriptional regulator
HEP87_RS24990	COG2252	PERMEase
HEP87_RS25000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEP87_RS25025	COG2814	Major facilitator Superfamily
HEP87_RS25035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEP87_RS25040	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP87_RS25045	COG1278	Cold shock
HEP87_RS25070	COG1061	Type III restriction enzyme res subunit
HEP87_RS25085	COG3973	AAA domain
HEP87_RS25125	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HEP87_RS25130	COG1263	PTS System
HEP87_RS25130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEP87_RS25205	COG0459	protein refolding
HEP87_RS25225	COG0463	Glycosyl transferase, family 2
HEP87_RS25290	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP87_RS25315	COG0308	aminopeptidase N
HEP87_RS25345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP87_RS25345	COG0723	plastoquinol--plastocyanin reductase activity
HEP87_RS25395	COG3629	intracellular signal transduction
HEP87_RS25395	COG3903	Transcriptional regulator
HEP87_RS25410	COG3842	ATPase activity
HEP87_RS25430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP87_RS25435	COG0215	cysteine-tRNA ligase activity
HEP87_RS25440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP87_RS25445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP87_RS25450	COG1329	Transcriptional regulator
HEP87_RS25470	COG5002	protein histidine kinase activity
HEP87_RS25530	COG0588	phosphoglycerate mutase activity
HEP87_RS25565	COG0438	transferase activity, transferring glycosyl groups
HEP87_RS25600	COG0494	nUDIX hydrolase
HEP87_RS25615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP87_RS25620	COG1090	epimerase
HEP87_RS25625	COG1595	DNA-templated transcription, initiation
HEP87_RS25645	COG1063	alcohol dehydrogenase
HEP87_RS25670	COG2188	Transcriptional regulator
HEP87_RS25680	COG2188	Transcriptional regulator
HEP87_RS25690	COG4552	Acetyltransferase involved in intracellular survival and related
HEP87_RS25705	COG1490	D-aminoacyl-tRNA deacylase activity
HEP87_RS25710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP87_RS25715	COG0735	belongs to the Fur family
HEP87_RS25720	COG3485	protocatechuate 3,4-dioxygenase
HEP87_RS25755	COG2897	thiosulfate sulfurtransferase activity
HEP87_RS25780	COG0745	RESPONSE REGULATOR receiver
HEP87_RS25785	COG1609	Transcriptional regulator
HEP87_RS25850	COG0745	RESPONSE REGULATOR receiver
HEP87_RS25855	COG1132	(ABC) transporter
HEP87_RS25865	COG0737	Belongs to the 5'-nucleotidase family
HEP87_RS25870	COG0456	acetyltransferase
HEP87_RS25885	COG1131	(ABC) transporter
HEP87_RS25910	COG1725	Transcriptional regulator
HEP87_RS25915	COG1131	(ABC) transporter
HEP87_RS25930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEP87_RS25960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEP87_RS25965	COG0306	phosphate transporter
HEP87_RS25975	COG1937	Protein conserved in bacteria
HEP87_RS25995	COG0277	FAD linked oxidase domain protein
HEP87_RS26000	COG0671	phosphoesterase, PA-phosphatase related
HEP87_RS26005	COG1196	nuclear chromosome segregation
HEP87_RS26005	COG0739	heme binding
HEP87_RS26005	COG0741	lytic transglycosylase activity
HEP87_RS26110	COG1252	NADH dehydrogenase
HEP87_RS26120	COG0366	Alpha amylase catalytic
HEP87_RS26120	COG1470	cell adhesion involved in biofilm formation
HEP87_RS26145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HEP87_RS26155	COG0667	Aldo Keto reductase
HEP87_RS26175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP87_RS26175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP87_RS26185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP87_RS26205	COG0513	Belongs to the DEAD box helicase family
HEP87_RS26245	COG1643	Atp-dependent helicase
HEP87_RS26305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP87_RS26310	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP87_RS26315	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP87_RS26345	COG3850	Histidine kinase
HEP87_RS26350	COG2197	response regulator
HEP87_RS26360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HEP87_RS26375	COG0151	Belongs to the GarS family
HEP87_RS26495	COG0433	COG0433 Predicted ATPase
HEP87_RS26510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP87_RS26545	COG1191	sigma factor activity
HEP87_RS26550	COG1191	sigma factor activity
HEP87_RS26570	COG0477	Major facilitator Superfamily
HEP87_RS26580	COG3467	pyridoxamine 5'-phosphate
HEP87_RS26590	COG0477	Major facilitator Superfamily
HEP87_RS26595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP87_RS26605	COG2205	protein histidine kinase activity
HEP87_RS26610	COG0745	RESPONSE REGULATOR receiver
HEP87_RS26635	COG1846	Transcriptional regulator
HEP87_RS26665	COG0494	nUDIX hydrolase
HEP87_RS26690	COG2188	Transcriptional regulator
HEP87_RS26720	COG0582	viral genome integration into host DNA
HEP87_RS26925	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS26930	COG1595	DNA-templated transcription, initiation
HEP87_RS26955	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS27030	COG0653	protein targeting
HEP87_RS27050	COG0006	proline dipeptidase activity
HEP87_RS27065	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HEP87_RS27125	COG2837	iron assimilation
HEP87_RS27135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEP87_RS27140	COG0561	phosphatase activity
HEP87_RS27170	COG1131	(ABC) transporter
HEP87_RS27180	COG0789	Transcriptional regulator
HEP87_RS27185	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP87_RS27195	COG0561	phosphatase activity
HEP87_RS27210	COG1294	oxidase, subunit
HEP87_RS27215	COG1271	oxidase subunit
HEP87_RS27220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP87_RS27225	COG1609	Transcriptional regulator
HEP87_RS27245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HEP87_RS27270	COG0662	Cupin 2, conserved barrel domain protein
HEP87_RS27275	COG1950	PFAM Membrane protein of
HEP87_RS27280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP87_RS27285	COG0626	cystathionine gamma-synthase activity
HEP87_RS27320	COG2814	Major facilitator Superfamily
HEP87_RS27340	COG0305	Participates in initiation and elongation during chromosome replication
HEP87_RS27350	COG0359	binds to the 23S rRNA
HEP87_RS27355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEP87_RS27360	COG0629	single-stranded DNA binding
HEP87_RS27365	COG0360	Binds together with S18 to 16S ribosomal RNA
HEP87_RS27390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEP87_RS27400	COG1260	myo-inositol-1-phosphate synthase
HEP87_RS27415	COG0617	tRNA 3'-terminal CCA addition
HEP87_RS27430	COG0515	serine threonine protein kinase
HEP87_RS27430	COG2815	serine threonine protein kinase
HEP87_RS27435	COG1595	DNA-templated transcription, initiation
HEP87_RS27445	COG0492	ferredoxin-NADP+ reductase activity
HEP87_RS27450	COG3118	belongs to the thioredoxin family
HEP87_RS27465	COG1192	Involved in chromosome partitioning
HEP87_RS27470	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP87_RS27480	COG0706	membrane insertase activity
HEP87_RS27485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HEP87_RS27490	COG0594	ribonuclease P activity
HEP87_RS27495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HEP87_RS27500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HEP87_RS27505	COG0592	DNA-directed DNA polymerase activity
HEP87_RS27510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP87_RS27515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP87_RS27520	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HEP87_RS27525	COG0187	DNA topoisomerase II activity
HEP87_RS27530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEP87_RS27585	COG0705	Rhomboid family
HEP87_RS27600	COG3764	Sortase (surface protein transpeptidase)
HEP87_RS27615	COG3764	Sortase (surface protein transpeptidase)
HEP87_RS27620	COG3764	Sortase (surface protein transpeptidase)
HEP87_RS27630	COG0515	serine threonine protein kinase
HEP87_RS27635	COG0768	penicillin binding
HEP87_RS27650	COG1716	ATPase activity
HEP87_RS27655	COG1716	ATPase activity
HEP87_RS27685	COG0745	RESPONSE REGULATOR receiver
HEP87_RS27695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP87_RS27700	COG4770	biotin carboxylase activity
HEP87_RS27715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP87_RS27760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP87_RS27790	COG0475	glutathione-regulated potassium exporter activity
HEP87_RS27800	COG1733	regulation of RNA biosynthetic process
HEP87_RS27805	COG0477	Major facilitator Superfamily
HEP87_RS27825	COG0277	FAD linked oxidase domain protein
HEP87_RS27845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HEP87_RS27850	COG1733	regulation of RNA biosynthetic process
HEP87_RS27895	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS27900	COG1309	transcriptional regulator
HEP87_RS27905	COG1522	sequence-specific DNA binding
HEP87_RS27925	COG0746	molybdenum cofactor guanylyltransferase activity
HEP87_RS27950	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS27950	COG0604	alcohol dehydrogenase
HEP87_RS27950	COG3321	synthase
HEP87_RS27965	COG0515	serine threonine protein kinase
HEP87_RS27970	COG0515	serine threonine protein kinase
HEP87_RS27995	COG0022	dehydrogenase e1 component
HEP87_RS28000	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP87_RS28065	COG1362	aminopeptidase activity
HEP87_RS28070	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS28080	COG1741	Belongs to the pirin family
HEP87_RS28095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HEP87_RS28125	COG3866	Pectate lyase
HEP87_RS28135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP87_RS28150	COG0583	DNA-binding transcription factor activity
HEP87_RS28170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP87_RS28175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP87_RS28210	COG0745	RESPONSE REGULATOR receiver
HEP87_RS28235	COG1473	amidohydrolase
HEP87_RS28255	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HEP87_RS28265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP87_RS28295	COG0222	ribosome binding
HEP87_RS28305	COG1278	Cold shock
HEP87_RS28345	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEP87_RS28395	COG2815	serine threonine protein kinase
HEP87_RS28395	COG0515	serine threonine protein kinase
HEP87_RS28405	COG1301	dicarboxylic acid transport
HEP87_RS28415	COG1595	DNA-templated transcription, initiation
HEP87_RS28430	COG0561	phosphatase activity
HEP87_RS28475	COG0745	RESPONSE REGULATOR receiver
HEP87_RS28480	COG5002	protein histidine kinase activity
HEP87_RS28490	COG2409	Drug exporters of the RND superfamily
HEP87_RS28495	COG4585	Histidine kinase
HEP87_RS28500	COG2197	response regulator
HEP87_RS28530	COG0640	Transcriptional regulator
HEP87_RS28535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEP87_RS28545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP87_RS28605	COG0702	epimerase
HEP87_RS28630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP87_RS28640	COG2326	polyphosphate kinase activity
HEP87_RS28645	COG3387	PFAM Glycoside hydrolase 15-related
HEP87_RS28655	COG0596	Alpha beta hydrolase
HEP87_RS28655	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP87_RS28715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP87_RS28740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP87_RS28745	COG1993	acr, cog1993
HEP87_RS28750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP87_RS28765	COG2205	protein histidine kinase activity
HEP87_RS28770	COG0745	RESPONSE REGULATOR receiver
HEP87_RS28835	COG0717	Belongs to the dCTP deaminase family
HEP87_RS28880	COG2181	nitrate reductase activity
HEP87_RS28880	COG0247	lactate metabolic process
HEP87_RS28890	COG0443	Heat shock 70 kDa protein
HEP87_RS28895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP87_RS28900	COG0484	heat shock protein binding
HEP87_RS28905	COG0789	Transcriptional regulator
HEP87_RS28910	COG5297	Belongs to the glycosyl hydrolase family 6
HEP87_RS28910	COG4733	cellulase activity
HEP87_RS28930	COG4213	ABC transporter substrate-binding protein
HEP87_RS28970	COG1305	Transglutaminase-like
HEP87_RS29010	COG0542	response to heat
HEP87_RS29030	COG2197	response regulator
HEP87_RS29040	COG3655	Transcriptional regulator
HEP87_RS29060	COG1136	(ABC) transporter
HEP87_RS29075	COG2161	toxin-antitoxin pair type II binding
HEP87_RS29095	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HEP87_RS29110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP87_RS29115	COG0191	fructose-bisphosphate aldolase activity
HEP87_RS29135	COG3844	kynureninase activity
HEP87_RS29160	COG4585	Histidine kinase
HEP87_RS29165	COG2197	response regulator
HEP87_RS29185	COG3559	Exporter of polyketide antibiotics
HEP87_RS29190	COG1131	(ABC) transporter
HEP87_RS29205	COG4303	Ethanolamine ammonia lyase large subunit
HEP87_RS29220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP87_RS29265	COG0737	Belongs to the 5'-nucleotidase family
HEP87_RS29285	COG0693	protein deglycase activity
HEP87_RS29300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP87_RS29310	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEP87_RS29315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HEP87_RS29430	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP87_RS29430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP87_RS29435	COG3903	Transcriptional regulator
HEP87_RS29435	COG3629	intracellular signal transduction
HEP87_RS29440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP87_RS29440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP87_RS29445	COG3251	PFAM MbtH domain protein
HEP87_RS29450	COG2175	clavaminate synthase activity
HEP87_RS29460	COG5285	phytanoyl-CoA dioxygenase
HEP87_RS29510	COG1408	metallophosphoesterase
HEP87_RS29535	COG0003	Pfam Anion-transporting ATPase
HEP87_RS29560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP87_RS29590	COG0596	Alpha beta hydrolase
HEP87_RS29600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEP87_RS29605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP87_RS29610	COG0659	secondary active sulfate transmembrane transporter activity
HEP87_RS29650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HEP87_RS29700	COG1111	helicase
HEP87_RS29700	COG1205	dead DEAH box helicase
HEP87_RS29705	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP87_RS29710	COG2172	sigma factor antagonist activity
HEP87_RS29715	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP87_RS29740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP87_RS29740	COG1754	DNA topoisomerase type I activity
HEP87_RS29745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP87_RS29750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEP87_RS29765	COG3903	Transcriptional regulator
HEP87_RS29765	COG3629	intracellular signal transduction
HEP87_RS29815	COG2197	response regulator
HEP87_RS29820	COG3850	Histidine kinase
HEP87_RS29840	COG2197	response regulator
HEP87_RS29845	COG4585	Histidine kinase
HEP87_RS29860	COG3251	PFAM MbtH domain protein
HEP87_RS29870	COG2175	clavaminate synthase activity
HEP87_RS29965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEP87_RS29970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEP87_RS29975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP87_RS29980	COG0254	rRNA binding
HEP87_RS29995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEP87_RS30015	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS30020	COG2318	DinB family
HEP87_RS30030	COG0076	glutamate decarboxylase activity
HEP87_RS30040	COG0789	Transcriptional regulator
HEP87_RS30045	COG0586	Pfam SNARE associated Golgi protein
HEP87_RS30055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP87_RS30060	COG2027	D-alanyl-D-alanine carboxypeptidase
HEP87_RS30070	COG0037	tRNA processing
HEP87_RS30085	COG0302	gtp cyclohydrolase
HEP87_RS30100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP87_RS30115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP87_RS30115	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP87_RS30140	COG0649	NAD binding
HEP87_RS30155	COG2197	response regulator
HEP87_RS30160	COG1660	Displays ATPase and GTPase activities
HEP87_RS30185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HEP87_RS30190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEP87_RS30200	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HEP87_RS30220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HEP87_RS30255	COG0739	heme binding
HEP87_RS30270	COG2205	protein histidine kinase activity
HEP87_RS30275	COG0745	RESPONSE REGULATOR receiver
HEP87_RS30285	COG1595	DNA-templated transcription, initiation
HEP87_RS30300	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HEP87_RS30325	COG0248	Ppx GppA phosphatase
HEP87_RS30330	COG1082	Xylose isomerase domain protein TIM barrel
HEP87_RS30335	COG1309	transcriptional regulator
HEP87_RS30340	COG0129	dihydroxy-acid dehydratase activity
HEP87_RS30345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP87_RS30345	COG0515	serine threonine protein kinase
HEP87_RS30370	COG1129	ABC transporter
HEP87_RS30370	COG0842	Transport permease protein
HEP87_RS30380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEP87_RS30385	COG0180	Tryptophanyl-tRNA synthetase
HEP87_RS30420	COG0123	including yeast histone deacetylase and acetoin utilization protein
HEP87_RS30470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HEP87_RS30480	COG0181	hydroxymethylbilane synthase activity
HEP87_RS30485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP87_RS30485	COG1648	precorrin-2 dehydrogenase activity
HEP87_RS30490	COG0113	porphobilinogen synthase activity
HEP87_RS30510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP87_RS30525	COG0018	arginyl-trna synthetase
HEP87_RS30550	COG1690	Belongs to the RtcB family
HEP87_RS30575	COG1742	UPF0060 membrane protein
HEP87_RS30585	COG1846	Transcriptional regulator
HEP87_RS30590	COG1733	regulation of RNA biosynthetic process
HEP87_RS30605	COG0583	DNA-binding transcription factor activity
HEP87_RS30615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS30620	COG0431	NADPH-dependent FMN reductase
HEP87_RS30630	COG2205	protein histidine kinase activity
HEP87_RS30645	COG0531	amino acid
HEP87_RS30650	COG2197	response regulator
HEP87_RS30660	COG1136	(ABC) transporter
HEP87_RS30665	COG0577	efflux transmembrane transporter activity
HEP87_RS30665	COG1136	(ABC) transporter
HEP87_RS30695	COG0501	Belongs to the peptidase M48B family
HEP87_RS30705	COG1968	undecaprenyl-diphosphatase activity
HEP87_RS30730	COG0531	amino acid
HEP87_RS30740	COG0598	Magnesium transport protein CorA
HEP87_RS30750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP87_RS30755	COG0406	alpha-ribazole phosphatase activity
HEP87_RS30775	COG1333	cytochrome c biogenesis protein
HEP87_RS30780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEP87_RS30825	COG3321	synthase
HEP87_RS30825	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS30825	COG0604	alcohol dehydrogenase
HEP87_RS30830	COG0640	Transcriptional regulator
HEP87_RS30850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEP87_RS30855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEP87_RS30860	COG0163	prenyltransferase activity
HEP87_RS30870	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP87_RS30920	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP87_RS30935	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP87_RS30965	COG2226	methyltransferase
HEP87_RS30995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP87_RS31000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP87_RS31005	COG0649	NAD binding
HEP87_RS31015	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP87_RS31020	COG1034	ATP synthesis coupled electron transport
HEP87_RS31025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEP87_RS31030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP87_RS31040	COG0713	ATP synthesis coupled electron transport
HEP87_RS31045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP87_RS31055	COG1007	ATP synthesis coupled electron transport
HEP87_RS31065	COG0514	ATP-dependent DNA helicase (RecQ)
HEP87_RS31075	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HEP87_RS31080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP87_RS31095	COG2188	Transcriptional regulator
HEP87_RS31110	COG0492	ferredoxin-NADP+ reductase activity
HEP87_RS31120	COG5280	Phage tail tape measure protein TP901
HEP87_RS31120	COG3953	SLT domain
HEP87_RS31150	COG1131	(ABC) transporter
HEP87_RS31160	COG0655	NAD(P)H dehydrogenase (quinone) activity
HEP87_RS31190	COG0702	epimerase
HEP87_RS31195	COG1733	regulation of RNA biosynthetic process
HEP87_RS31200	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEP87_RS31205	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEP87_RS31205	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEP87_RS31225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP87_RS31230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP87_RS31240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEP87_RS31250	COG0839	Belongs to the complex I subunit 6 family
HEP87_RS31255	COG0713	ATP synthesis coupled electron transport
HEP87_RS31260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP87_RS31270	COG1007	ATP synthesis coupled electron transport
HEP87_RS31275	COG0501	Belongs to the peptidase M48B family
HEP87_RS31280	COG3304	Inner membrane component domain
HEP87_RS31300	COG2261	transglycosylase associated protein
HEP87_RS31305	COG1666	GTP binding
HEP87_RS31345	COG0702	epimerase
HEP87_RS31350	COG0402	S-adenosylhomocysteine deaminase activity
HEP87_RS31365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP87_RS31370	COG2030	dehydratase
HEP87_RS31385	COG0477	Major facilitator Superfamily
HEP87_RS31390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP87_RS31395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP87_RS31410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP87_RS31415	COG0436	Aminotransferase
HEP87_RS31435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP87_RS31440	COG0081	regulation of translation
HEP87_RS31455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HEP87_RS31460	COG0222	ribosome binding
HEP87_RS31470	COG0085	RNA polymerase activity
HEP87_RS31475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP87_RS31505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP87_RS31510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HEP87_RS31515	COG0049	tRNA binding
HEP87_RS31520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP87_RS31525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP87_RS31545	COG2124	cytochrome p450
HEP87_RS31590	COG1404	Belongs to the peptidase S8 family
HEP87_RS31645	COG0051	transcription antitermination factor activity, RNA binding
HEP87_RS31655	COG0088	Forms part of the polypeptide exit tunnel
HEP87_RS31660	COG0089	rRNA binding
HEP87_RS31665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP87_RS31670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEP87_RS31675	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HEP87_RS31680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HEP87_RS31685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEP87_RS31690	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP87_RS31695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP87_RS31700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HEP87_RS31705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP87_RS31710	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP87_RS31715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEP87_RS31725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HEP87_RS31730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HEP87_RS31735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HEP87_RS31740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEP87_RS31745	COG1841	ribosomal large subunit assembly
HEP87_RS31750	COG0200	Binds to the 23S rRNA
HEP87_RS31760	COG0563	adenylate kinase activity
HEP87_RS31780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEP87_RS31785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HEP87_RS31790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEP87_RS31795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEP87_RS31800	COG0202	RNA polymerase activity
HEP87_RS31805	COG0203	ribosomal protein L17
HEP87_RS31810	COG0101	tRNA pseudouridine synthase activity
HEP87_RS31830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEP87_RS31835	COG0463	Glycosyl transferase, family 2
HEP87_RS31845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HEP87_RS31850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HEP87_RS31855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP87_RS31865	COG1072	(Pantothenic acid kinase))
HEP87_RS31870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP87_RS31910	COG0736	holo-[acyl-carrier-protein] synthase activity
HEP87_RS31925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEP87_RS31935	COG0802	atpase or kinase
HEP87_RS31950	COG0456	acetyltransferase
HEP87_RS31950	COG1214	PFAM Peptidase M22, glycoprotease
HEP87_RS31960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEP87_RS31970	COG1609	Transcriptional regulator
HEP87_RS31980	COG1175	transmembrane transport
HEP87_RS31985	COG0395	ABC-type sugar transport system, permease component
HEP87_RS31990	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP87_RS31995	COG1609	Transcriptional regulator
HEP87_RS32030	COG4941	Belongs to the sigma-70 factor family
HEP87_RS32040	COG0726	polysaccharide deacetylase
HEP87_RS32045	COG0726	polysaccharide deacetylase
HEP87_RS32050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HEP87_RS32055	COG0459	protein refolding
HEP87_RS32065	COG4221	oxidoreductase activity
HEP87_RS32075	COG0583	DNA-binding transcription factor activity
HEP87_RS32090	COG1595	DNA-templated transcription, initiation
HEP87_RS32100	COG0516	GMP reductase activity
HEP87_RS32115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEP87_RS32135	COG0515	serine threonine protein kinase
HEP87_RS32145	COG0515	serine threonine protein kinase
HEP87_RS32160	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS32185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP87_RS32185	COG0519	Catalyzes the synthesis of GMP from XMP
HEP87_RS32230	COG2197	response regulator
HEP87_RS32275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS32275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS32295	COG0714	Associated with various cellular activities
HEP87_RS32305	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP87_RS32320	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP87_RS32350	COG0138	bifunctional purine biosynthesis protein purh
HEP87_RS32370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP87_RS32390	COG0039	L-malate dehydrogenase activity
HEP87_RS32415	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS32425	COG4175	Glycine betaine
HEP87_RS32425	COG0517	IMP dehydrogenase activity
HEP87_RS32430	COG4176	ABC-type proline glycine betaine transport system permease component
HEP87_RS32445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP87_RS32450	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP87_RS32460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP87_RS32480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP87_RS32490	COG3224	Antibiotic biosynthesis monooxygenase
HEP87_RS32515	COG0754	glutathionylspermidine amidase activity
HEP87_RS32520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP87_RS32525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP87_RS32535	COG0180	Tryptophanyl-tRNA synthetase
HEP87_RS32570	COG1295	ribonuclease BN
HEP87_RS32585	COG1408	metallophosphoesterase
HEP87_RS32590	COG4166	transmembrane transport
HEP87_RS32605	COG2205	protein histidine kinase activity
HEP87_RS32610	COG0745	RESPONSE REGULATOR receiver
HEP87_RS32615	COG2409	Drug exporters of the RND superfamily
HEP87_RS32625	COG1309	transcriptional regulator
HEP87_RS32670	COG1053	succinate dehydrogenase
HEP87_RS32680	COG2009	succinate dehydrogenase
HEP87_RS32720	COG1595	DNA-templated transcription, initiation
HEP87_RS32725	COG1595	DNA-templated transcription, initiation
HEP87_RS32740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS32740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS32765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP87_RS32775	COG1216	Glycosyl transferase, family 2
HEP87_RS32790	COG2089	acid synthase
HEP87_RS32800	COG0573	inorganic phosphate transmembrane transporter activity
HEP87_RS32825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEP87_RS32830	COG4195	phage-related replication protein
HEP87_RS32895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEP87_RS32895	COG1473	amidohydrolase
HEP87_RS32900	COG1744	ABC transporter substrate-binding protein PnrA-like
HEP87_RS32905	COG1744	ABC transporter substrate-binding protein PnrA-like
HEP87_RS32955	COG0592	DNA-directed DNA polymerase activity
HEP87_RS32960	COG2814	Major facilitator Superfamily
HEP87_RS32965	COG0583	DNA-binding transcription factor activity
HEP87_RS32975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP87_RS33000	COG2205	protein histidine kinase activity
HEP87_RS33005	COG0745	RESPONSE REGULATOR receiver
HEP87_RS33010	COG1595	DNA-templated transcription, initiation
HEP87_RS33025	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS33030	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS33050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP87_RS33090	COG0424	maF-like protein
HEP87_RS33105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP87_RS33115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP87_RS33130	COG1024	Enoyl-CoA hydratase
HEP87_RS33140	COG2986	histidine ammonia-lyase
HEP87_RS33145	COG1278	Cold shock
HEP87_RS33180	COG1136	(ABC) transporter
HEP87_RS33185	COG1404	Belongs to the peptidase S8 family
HEP87_RS33200	COG1064	alcohol dehydrogenase
HEP87_RS33205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP87_RS33210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP87_RS33220	COG2132	Multicopper oxidase
HEP87_RS33300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP87_RS33325	COG2255	four-way junction helicase activity
HEP87_RS33330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP87_RS33355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP87_RS33360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP87_RS33370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP87_RS33395	COG1331	Highly conserved protein containing a thioredoxin domain
HEP87_RS33425	COG1309	transcriptional regulator
HEP87_RS33440	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HEP87_RS33515	COG0436	Aminotransferase
HEP87_RS33530	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HEP87_RS33545	COG1414	Transcriptional regulator
HEP87_RS33550	COG0251	oxidation-reduction process
HEP87_RS33555	COG2610	gluconate transmembrane transporter activity
HEP87_RS33605	COG4257	antibiotic catabolic process
HEP87_RS33645	COG2894	cell division
HEP87_RS33680	COG2197	response regulator
HEP87_RS33700	COG2885	chlorophyll binding
HEP87_RS33705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEP87_RS33740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP87_RS33745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP87_RS33760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP87_RS33765	COG0450	alkyl hydroperoxide reductase
HEP87_RS33780	COG1136	(ABC) transporter
HEP87_RS33820	COG0114	fumarate hydratase activity
HEP87_RS33835	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP87_RS33835	COG3103	Sh3 type 3 domain protein
HEP87_RS33835	COG4991	sh3 domain protein
HEP87_RS33840	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEP87_RS33840	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEP87_RS33865	COG0778	Nitroreductase
HEP87_RS33870	COG1722	exodeoxyribonuclease VII activity
HEP87_RS33875	COG1570	exodeoxyribonuclease VII activity
HEP87_RS33880	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP87_RS33895	COG0012	GTP binding
HEP87_RS34035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEP87_RS34045	COG1053	succinate dehydrogenase
HEP87_RS34080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP87_RS34085	COG0444	Belongs to the ABC transporter superfamily
HEP87_RS34090	COG4608	Belongs to the ABC transporter superfamily
HEP87_RS34095	COG0346	lactoylglutathione lyase activity
HEP87_RS34110	COG0601	transmembrane transport
HEP87_RS34115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP87_RS34120	COG0444	Belongs to the ABC transporter superfamily
HEP87_RS34125	COG4608	Belongs to the ABC transporter superfamily
HEP87_RS34155	COG1131	(ABC) transporter
HEP87_RS34165	COG4585	Histidine kinase
HEP87_RS34170	COG2197	response regulator
HEP87_RS34205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP87_RS34210	COG1611	Belongs to the LOG family
HEP87_RS34215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEP87_RS34225	COG0519	Catalyzes the synthesis of GMP from XMP
HEP87_RS34230	COG1024	Enoyl-CoA hydratase
HEP87_RS34245	COG1595	DNA-templated transcription, initiation
HEP87_RS34260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP87_RS34285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP87_RS34295	COG0598	Magnesium transport protein CorA
HEP87_RS34305	COG2814	Major facilitator Superfamily
HEP87_RS34320	COG2095	MarC family integral membrane protein
HEP87_RS34330	COG1432	Conserved Protein
HEP87_RS34335	COG0596	Alpha beta hydrolase
HEP87_RS34380	COG0747	negative chemotaxis
HEP87_RS34390	COG0601	transmembrane transport
HEP87_RS34430	COG0596	Alpha beta hydrolase
HEP87_RS34455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP87_RS34495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP87_RS34550	COG3480	Lon protease (S16) C-terminal proteolytic domain
HEP87_RS34560	COG1615	UPF0182 protein
HEP87_RS34585	COG0753	catalase activity
HEP87_RS34590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HEP87_RS34590	COG0517	IMP dehydrogenase activity
HEP87_RS34595	COG0483	inositol monophosphate 1-phosphatase activity
HEP87_RS34625	COG2135	peptidase activity
HEP87_RS34635	COG1595	DNA-templated transcription, initiation
HEP87_RS34640	COG5662	AntiSigma factor
HEP87_RS34645	COG2199	diguanylate cyclase activity
HEP87_RS34645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HEP87_RS34660	COG0242	peptide deformylase activity
HEP87_RS34670	COG2124	cytochrome p450
HEP87_RS34690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP87_RS34715	COG2188	Transcriptional regulator
HEP87_RS34720	COG2182	Extracellular solute-binding protein
HEP87_RS34725	COG1175	transmembrane transport
HEP87_RS34730	COG0395	ABC-type sugar transport system, permease component
HEP87_RS34740	COG0363	glucosamine-6-phosphate deaminase activity
HEP87_RS34750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP87_RS34765	COG1597	lipid kinase activity
HEP87_RS34810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP87_RS34875	COG3321	synthase
HEP87_RS34875	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS34875	COG0604	alcohol dehydrogenase
HEP87_RS34895	COG4106	trans-aconitate 2-methyltransferase activity
HEP87_RS34900	COG1126	abc transporter atp-binding protein
HEP87_RS34915	COG0281	malic enzyme
HEP87_RS34920	COG0604	alcohol dehydrogenase
HEP87_RS34955	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP87_RS34955	COG0567	Dehydrogenase, E1 component
HEP87_RS34960	COG2205	protein histidine kinase activity
HEP87_RS34965	COG0745	RESPONSE REGULATOR receiver
HEP87_RS34970	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP87_RS35000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEP87_RS35050	COG3883	PFAM NLP P60 protein
HEP87_RS35050	COG0791	NLP P60 protein
HEP87_RS35090	COG0768	penicillin binding
HEP87_RS35095	COG0772	Belongs to the SEDS family
HEP87_RS35130	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEP87_RS35140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP87_RS35250	COG2188	Transcriptional regulator
HEP87_RS35315	COG0745	RESPONSE REGULATOR receiver
HEP87_RS35320	COG0018	arginyl-trna synthetase
HEP87_RS35325	COG0019	diaminopimelate decarboxylase activity
HEP87_RS35330	COG0460	homoserine dehydrogenase
HEP87_RS35335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP87_RS35340	COG0083	homoserine kinase activity
HEP87_RS35355	COG1316	TRANSCRIPTIONal
HEP87_RS35360	COG0254	rRNA binding
HEP87_RS35365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP87_RS35370	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP87_RS35380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP87_RS35385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP87_RS35390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP87_RS35405	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEP87_RS35410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP87_RS35415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEP87_RS35420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP87_RS35425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HEP87_RS35430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEP87_RS35435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP87_RS35450	COG2197	response regulator
HEP87_RS35455	COG4585	Histidine kinase
HEP87_RS35485	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS35500	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HEP87_RS35545	COG1131	(ABC) transporter
HEP87_RS35565	COG0183	Belongs to the thiolase family
HEP87_RS35600	COG2814	Major facilitator Superfamily
HEP87_RS35645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS35645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS35680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEP87_RS35685	COG0280	phosphate acetyltransferase
HEP87_RS35685	COG0857	belongs to the CobB CobQ family
HEP87_RS35690	COG0205	6-phosphofructokinase activity
HEP87_RS35700	COG0395	ABC-type sugar transport system, permease component
HEP87_RS35705	COG1175	transmembrane transport
HEP87_RS35735	COG3290	protein histidine kinase activity
HEP87_RS35740	COG1301	dicarboxylic acid transport
HEP87_RS35760	COG0667	Aldo Keto reductase
HEP87_RS35770	COG1522	sequence-specific DNA binding
HEP87_RS35795	COG3281	Trehalose synthase
HEP87_RS35805	COG0366	Alpha amylase catalytic
HEP87_RS35815	COG0058	SHG alpha-glucan phosphorylase activity
HEP87_RS35840	COG1132	(ABC) transporter
HEP87_RS35845	COG1132	(ABC) transporter
HEP87_RS35850	COG1132	(ABC) transporter
HEP87_RS35855	COG1131	(ABC) transporter
HEP87_RS35865	COG4585	Histidine kinase
HEP87_RS35870	COG2197	response regulator
HEP87_RS35880	COG1376	ErfK ybiS ycfS ynhG family protein
HEP87_RS35885	COG1376	ErfK ybiS ycfS ynhG family protein
HEP87_RS35930	COG1119	ATPase activity
HEP87_RS35935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP87_RS35975	COG1760	l-serine dehydratase
HEP87_RS35980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP87_RS35985	COG0509	glycine decarboxylation via glycine cleavage system
HEP87_RS35990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP87_RS36025	COG0444	Belongs to the ABC transporter superfamily
HEP87_RS36030	COG4608	Belongs to the ABC transporter superfamily
HEP87_RS36045	COG2860	membrane
HEP87_RS36065	COG2378	regulation of single-species biofilm formation
HEP87_RS36105	COG0482	sulfurtransferase activity
HEP87_RS36115	COG1611	Belongs to the LOG family
HEP87_RS36120	COG4221	oxidoreductase activity
HEP87_RS36130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP87_RS36140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEP87_RS36145	COG0154	amidase activity
HEP87_RS36155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEP87_RS36160	COG2409	Drug exporters of the RND superfamily
HEP87_RS36165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP87_RS36190	COG2133	pyrroloquinoline quinone binding
HEP87_RS36195	COG0667	Aldo Keto reductase
HEP87_RS36205	COG5001	Diguanylate cyclase
HEP87_RS36215	COG0440	acetolactate synthase activity
HEP87_RS36220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP87_RS36230	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP87_RS36230	COG1672	PFAM Archaeal ATPase
HEP87_RS36255	COG3214	Protein conserved in bacteria
HEP87_RS36265	COG0506	proline dehydrogenase activity
HEP87_RS36270	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS36295	COG0477	Major facilitator Superfamily
HEP87_RS36305	COG0473	3-isopropylmalate dehydrogenase activity
HEP87_RS36310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP87_RS36340	COG0804	urea catabolic process
HEP87_RS36345	COG2957	Belongs to the agmatine deiminase family
HEP87_RS36355	COG0477	Major facilitator Superfamily
HEP87_RS36360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP87_RS36390	COG2197	response regulator
HEP87_RS36400	COG1131	(ABC) transporter
HEP87_RS36435	COG4585	Histidine kinase
HEP87_RS36440	COG2197	response regulator
HEP87_RS36445	COG2353	YceI-like domain
HEP87_RS36450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP87_RS36470	COG2018	Roadblock/LC7 domain
HEP87_RS36490	COG2018	Roadblock/LC7 domain
HEP87_RS36505	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP87_RS36510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP87_RS36560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEP87_RS36565	COG0066	3-isopropylmalate dehydratase activity
HEP87_RS36575	COG0776	regulation of translation
HEP87_RS36585	COG1920	GTP binding
HEP87_RS36595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP87_RS36600	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP87_RS36625	COG3903	Transcriptional regulator
HEP87_RS36625	COG3629	intracellular signal transduction
HEP87_RS36630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEP87_RS36635	COG1461	Dihydroxyacetone kinase
HEP87_RS36645	COG0326	Molecular chaperone. Has ATPase activity
HEP87_RS36655	COG0742	ribosomal rna small subunit methyltransferase
HEP87_RS36660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEP87_RS36675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HEP87_RS36680	COG0571	ribonuclease III activity
HEP87_RS36685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP87_RS36690	COG1733	regulation of RNA biosynthetic process
HEP87_RS36735	COG2340	Cysteine-rich secretory protein family
HEP87_RS36740	COG1254	Belongs to the acylphosphatase family
HEP87_RS36755	COG0477	Major facilitator Superfamily
HEP87_RS36795	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HEP87_RS36805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP87_RS36815	COG0442	prolyl-tRNA aminoacylation
HEP87_RS36825	COG0228	four-way junction DNA binding
HEP87_RS36830	COG1837	Belongs to the UPF0109 family
HEP87_RS36835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP87_RS36840	COG0336	Belongs to the RNA methyltransferase TrmD family
HEP87_RS36845	COG0335	large ribosomal subunit rRNA binding
HEP87_RS36865	COG0681	Belongs to the peptidase S26 family
HEP87_RS36875	COG0792	nuclease activity
HEP87_RS36890	COG1191	sigma factor activity
HEP87_RS36905	COG0052	Belongs to the universal ribosomal protein uS2 family
HEP87_RS36910	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP87_RS36915	COG0528	UMP kinase activity
HEP87_RS36920	COG0233	cytoplasmic translational termination
HEP87_RS36925	COG0575	Belongs to the CDS family
HEP87_RS36935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP87_RS36945	COG4208	sulfate ABC transporter
HEP87_RS36950	COG3842	ATPase activity
HEP87_RS36980	COG1136	(ABC) transporter
HEP87_RS36985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP87_RS36995	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS37060	COG1522	sequence-specific DNA binding
HEP87_RS37065	COG0477	Major facilitator Superfamily
HEP87_RS37070	COG2226	methyltransferase
HEP87_RS37090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP87_RS37105	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS37115	COG3842	ATPase activity
HEP87_RS37120	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP87_RS37125	COG1177	transmembrane transport
HEP87_RS37130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP87_RS37160	COG2508	Transcriptional regulator
HEP87_RS37160	COG2508	Transcriptional regulator
HEP87_RS37165	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS37175	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP87_RS37185	COG4209	transmembrane transport
HEP87_RS37190	COG0395	ABC-type sugar transport system, permease component
HEP87_RS37230	COG5297	Belongs to the glycosyl hydrolase family 6
HEP87_RS37245	COG0653	protein targeting
HEP87_RS37260	COG0750	zinc metalloprotease
HEP87_RS37265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEP87_RS37280	COG0442	prolyl-tRNA aminoacylation
HEP87_RS37300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP87_RS37325	COG0779	Required for maturation of 30S ribosomal subunits
HEP87_RS37350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HEP87_RS37355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEP87_RS37380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP87_RS37385	COG0601	transmembrane transport
HEP87_RS37420	COG1404	Belongs to the peptidase S8 family
HEP87_RS37495	COG1674	ftsk spoiiie
HEP87_RS37510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEP87_RS37515	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP87_RS37520	COG0612	Peptidase, M16
HEP87_RS37525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HEP87_RS37545	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HEP87_RS37550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP87_RS37555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEP87_RS37585	COG2208	phosphoserine phosphatase activity
HEP87_RS37585	COG2770	Histidine kinase
HEP87_RS37605	COG1674	ftsk spoiiie
HEP87_RS37615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP87_RS37625	COG1546	Belongs to the CinA family
HEP87_RS37625	COG1058	Belongs to the CinA family
HEP87_RS37630	COG1396	sequence-specific DNA binding
HEP87_RS37635	COG0783	Belongs to the Dps family
HEP87_RS37640	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS37645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP87_RS37680	COG0628	permease
HEP87_RS37690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP87_RS37735	COG0765	amino acid transport
HEP87_RS37740	COG0765	amino acid transport
HEP87_RS37745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP87_RS37750	COG1126	abc transporter atp-binding protein
HEP87_RS37755	COG0745	RESPONSE REGULATOR receiver
HEP87_RS37790	COG2197	response regulator
HEP87_RS37855	COG0789	Transcriptional regulator
HEP87_RS37870	COG4115	mRNA cleavage
HEP87_RS37885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HEP87_RS37910	COG0297	glycogen (starch) synthase activity
HEP87_RS37930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP87_RS37965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP87_RS37985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEP87_RS37995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEP87_RS38000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP87_RS38010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP87_RS38080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP87_RS38085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP87_RS38125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEP87_RS38160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP87_RS38165	COG1802	Transcriptional regulator
HEP87_RS38170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP87_RS38185	COG0187	DNA topoisomerase II activity
HEP87_RS38200	COG2197	response regulator
HEP87_RS38215	COG4565	transcriptional regulatory protein
HEP87_RS38225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP87_RS38235	COG4565	transcriptional regulatory protein
HEP87_RS38240	COG3290	protein histidine kinase activity
HEP87_RS38270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEP87_RS38275	COG0612	Peptidase, M16
HEP87_RS38300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP87_RS38305	COG1042	CoA-binding domain protein
HEP87_RS38305	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP87_RS38305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP87_RS38320	COG1435	thymidine kinase activity
HEP87_RS38370	COG0745	RESPONSE REGULATOR receiver
HEP87_RS38375	COG2205	protein histidine kinase activity
HEP87_RS38400	COG0756	dUTP diphosphatase activity
HEP87_RS38415	COG1136	(ABC) transporter
HEP87_RS38415	COG0577	efflux transmembrane transporter activity
HEP87_RS38445	COG0569	domain protein
HEP87_RS38450	COG0531	amino acid
HEP87_RS38545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP87_RS38550	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HEP87_RS38560	COG1215	transferase activity, transferring glycosyl groups
HEP87_RS38570	COG4310	Domain of unknown function (DUF2172)
HEP87_RS38585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP87_RS38620	COG0367	asparagine synthase
HEP87_RS38640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEP87_RS38690	COG0243	molybdopterin cofactor binding
HEP87_RS38695	COG1799	cell septum assembly
HEP87_RS38715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS38725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP87_RS38740	COG2235	arginine
HEP87_RS38745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP87_RS38750	COG0531	amino acid
HEP87_RS38760	COG1024	Enoyl-CoA hydratase
HEP87_RS38780	COG0529	Catalyzes the synthesis of activated sulfate
HEP87_RS38815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEP87_RS38830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HEP87_RS38840	COG1404	Belongs to the peptidase S8 family
HEP87_RS38845	COG0745	RESPONSE REGULATOR receiver
HEP87_RS38865	COG3537	Alpha-1,2-mannosidase
HEP87_RS38875	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS38885	COG1653	transport
HEP87_RS38890	COG1175	transmembrane transport
HEP87_RS38895	COG0395	ABC-type sugar transport system, permease component
HEP87_RS38900	COG1940	carbohydrate kinase activity
HEP87_RS38905	COG4213	ABC transporter substrate-binding protein
HEP87_RS38915	COG4214	carbohydrate transport
HEP87_RS38920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP87_RS38925	COG0531	amino acid
HEP87_RS38945	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS38945	COG1024	Enoyl-CoA hydratase
HEP87_RS38950	COG0183	Belongs to the thiolase family
HEP87_RS38975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP87_RS38990	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP87_RS39080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEP87_RS39120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP87_RS39125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP87_RS39145	COG2205	protein histidine kinase activity
HEP87_RS39145	COG3437	response regulator, receiver
HEP87_RS39145	COG4999	Histidine kinase
HEP87_RS39145	COG3850	Histidine kinase
HEP87_RS39190	COG0154	amidase activity
HEP87_RS39205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP87_RS39230	COG0642	Histidine kinase
HEP87_RS39315	COG1404	Belongs to the peptidase S8 family
HEP87_RS39345	COG0504	CTP synthase activity
HEP87_RS39355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP87_RS39490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEP87_RS39510	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HEP87_RS39540	COG0175	sulfate reduction
HEP87_RS39570	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS39585	COG1917	Cupin 2, conserved barrel domain protein
HEP87_RS39585	COG4977	sequence-specific DNA binding
HEP87_RS39610	COG1609	Transcriptional regulator
HEP87_RS39620	COG0297	glycogen (starch) synthase activity
HEP87_RS39650	COG2040	homocysteine
HEP87_RS39780	COG2018	Roadblock/LC7 domain
HEP87_RS39815	COG1131	(ABC) transporter
HEP87_RS39830	COG0395	ABC-type sugar transport system, permease component
HEP87_RS39835	COG1175	transmembrane transport
HEP87_RS39850	COG0277	FAD linked oxidase domain protein
HEP87_RS39960	COG3409	Peptidoglycan-binding domain 1 protein
HEP87_RS40010	COG1162	GTPase activity
HEP87_RS40020	COG3340	Belongs to the peptidase S51 family
HEP87_RS40060	COG0028	Belongs to the TPP enzyme family
HEP87_RS40110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP87_RS40115	COG2252	PERMEase
HEP87_RS40155	COG1132	(ABC) transporter
HEP87_RS40165	COG0596	Alpha beta hydrolase
HEP87_RS40170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP87_RS40185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP87_RS40185	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS40185	COG3321	synthase
HEP87_RS40185	COG4221	oxidoreductase activity
HEP87_RS40200	COG1477	protein flavinylation
HEP87_RS40215	COG0745	RESPONSE REGULATOR receiver
HEP87_RS40220	COG2205	protein histidine kinase activity
HEP87_RS40235	COG4977	sequence-specific DNA binding
HEP87_RS40240	COG3629	intracellular signal transduction
HEP87_RS40240	COG3903	Transcriptional regulator
HEP87_RS40280	COG1175	transmembrane transport
HEP87_RS40290	COG1609	Transcriptional regulator
HEP87_RS40295	COG3345	alpha-galactosidase
HEP87_RS40350	COG1609	Transcriptional regulator
HEP87_RS40355	COG1124	(ABC) transporter
HEP87_RS40405	COG0443	Heat shock 70 kDa protein
HEP87_RS40490	COG0598	Magnesium transport protein CorA
HEP87_RS40505	COG0583	DNA-binding transcription factor activity
HEP87_RS40525	COG2197	response regulator
HEP87_RS40535	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS40545	COG3960	tartronate-semialdehyde synthase activity
HEP87_RS40555	COG0753	catalase activity
HEP87_RS40560	COG2084	Dehydrogenase
HEP87_RS40565	COG3622	Belongs to the hyi family
HEP87_RS40585	COG2351	hydroxyisourate hydrolase activity
HEP87_RS40600	COG2233	PERMEase
HEP87_RS40615	COG1733	regulation of RNA biosynthetic process
HEP87_RS40630	COG0406	alpha-ribazole phosphatase activity
HEP87_RS40635	COG0436	Aminotransferase
HEP87_RS40655	COG2304	oxidoreductase activity
HEP87_RS40660	COG4264	IucA IucC family
HEP87_RS40715	COG1414	Transcriptional regulator
HEP87_RS40720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP87_RS40725	COG4266	Belongs to the allantoicase family
HEP87_RS40730	COG0598	Magnesium transport protein CorA
HEP87_RS40745	COG0667	Aldo Keto reductase
HEP87_RS40750	COG2197	response regulator
HEP87_RS40760	COG0673	inositol 2-dehydrogenase activity
HEP87_RS40765	COG2188	Transcriptional regulator
HEP87_RS40790	COG1940	carbohydrate kinase activity
HEP87_RS40825	COG0745	RESPONSE REGULATOR receiver
HEP87_RS40830	COG2205	protein histidine kinase activity
HEP87_RS40835	COG0586	Pfam SNARE associated Golgi protein
HEP87_RS40840	COG1968	undecaprenyl-diphosphatase activity
HEP87_RS40865	COG0671	phosphoesterase, PA-phosphatase related
HEP87_RS40870	COG0586	Pfam SNARE associated Golgi protein
HEP87_RS40895	COG1063	alcohol dehydrogenase
HEP87_RS40900	COG0395	ABC-type sugar transport system, permease component
HEP87_RS40915	COG1349	DNA-binding transcription factor activity
HEP87_RS40940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP87_RS40960	COG3629	intracellular signal transduction
HEP87_RS40960	COG3903	Transcriptional regulator
HEP87_RS40975	COG4977	sequence-specific DNA binding
HEP87_RS41005	COG2267	carboxylic ester hydrolase activity
HEP87_RS41020	COG0745	RESPONSE REGULATOR receiver
HEP87_RS41025	COG2205	protein histidine kinase activity
HEP87_RS41160	COG0202	RNA polymerase activity
HEP87_RS41230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEP87_RS41275	COG0076	glutamate decarboxylase activity
HEP87_RS41320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP87_RS41335	COG2175	clavaminate synthase activity
HEP87_RS41345	COG3246	L-lysine catabolic process to acetate
HEP87_RS41360	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS41395	COG3387	PFAM Glycoside hydrolase 15-related
HEP87_RS41735	COG1595	DNA-templated transcription, initiation
HEP87_RS41760	COG0644	oxidoreductase
HEP87_RS41765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP87_RS41770	COG0475	glutathione-regulated potassium exporter activity
HEP87_RS41790	COG1021	2,3-dihydroxybenzoate-AMP ligase
HEP87_RS41800	COG3433	isochorismatase activity
HEP87_RS41800	COG1535	isochorismatase
HEP87_RS41805	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS41880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP87_RS41885	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP87_RS41900	COG1126	abc transporter atp-binding protein
HEP87_RS41910	COG0765	amino acid transport
HEP87_RS41915	COG0765	amino acid transport
HEP87_RS41930	COG0405	Gamma-glutamyltransferase
HEP87_RS41975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP87_RS41985	COG1953	Uracil, thiamine, allantoin
HEP87_RS41995	COG2226	methyltransferase
HEP87_RS42005	COG3851	Histidine kinase
HEP87_RS42010	COG2197	response regulator
HEP87_RS42040	COG1131	(ABC) transporter
HEP87_RS42065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP87_RS42100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP87_RS42105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEP87_RS42110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP87_RS42160	COG0483	inositol monophosphate 1-phosphatase activity
HEP87_RS42175	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP87_RS42180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP87_RS42190	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS42195	COG0583	DNA-binding transcription factor activity
HEP87_RS42205	COG0477	Major facilitator Superfamily
HEP87_RS42220	COG1309	transcriptional regulator
HEP87_RS42270	COG0671	phosphoesterase, PA-phosphatase related
HEP87_RS42300	COG0640	Transcriptional regulator
HEP87_RS42345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP87_RS42350	COG1192	Involved in chromosome partitioning
HEP87_RS42395	COG0688	phosphatidylethanolamine metabolic process
HEP87_RS42400	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS42410	COG2301	Belongs to the HpcH HpaI aldolase family
HEP87_RS42415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS42415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP87_RS42420	COG0604	alcohol dehydrogenase
HEP87_RS42430	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS42440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP87_RS42440	COG0456	acetyltransferase
HEP87_RS42450	COG0596	Alpha beta hydrolase
HEP87_RS42515	COG2362	D-Aminopeptidase
HEP87_RS42520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP87_RS42530	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEP87_RS42555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEP87_RS42565	COG2226	methyltransferase
HEP87_RS42575	COG0488	(ABC) transporter
HEP87_RS42665	COG0443	Heat shock 70 kDa protein
HEP87_RS42685	COG0583	DNA-binding transcription factor activity
HEP87_RS42690	COG2154	pterin-4-alpha-carbinolamine dehydratase
HEP87_RS42705	COG2226	methyltransferase
HEP87_RS42720	COG2378	regulation of single-species biofilm formation
HEP87_RS42725	COG3401	FG-GAP repeat protein
HEP87_RS42735	COG0778	Nitroreductase
HEP87_RS42745	COG5297	Belongs to the glycosyl hydrolase family 6
HEP87_RS42745	COG4733	cellulase activity
HEP87_RS42755	COG5297	Belongs to the glycosyl hydrolase family 6
HEP87_RS42795	COG0656	L-ascorbic acid biosynthetic process
HEP87_RS42820	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HEP87_RS42830	COG3469	chitinase activity
HEP87_RS42835	COG3250	beta-galactosidase activity
HEP87_RS42850	COG0582	viral genome integration into host DNA
HEP87_RS43015	COG2264	protein methyltransferase activity
HEP87_RS43020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP87_RS43045	COG1404	Belongs to the peptidase S8 family
HEP87_RS43155	COG1846	Transcriptional regulator
HEP87_RS43160	COG1335	isochorismatase
HEP87_RS43170	COG0583	DNA-binding transcription factor activity
HEP87_RS43175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HEP87_RS43190	COG3383	formate dehydrogenase (NAD+) activity
HEP87_RS43195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEP87_RS43205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP87_RS43235	COG1940	carbohydrate kinase activity
HEP87_RS43240	COG1129	ABC transporter
HEP87_RS43245	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP87_RS43250	COG1879	ABC-type sugar transport system periplasmic component
HEP87_RS43255	COG0673	inositol 2-dehydrogenase activity
HEP87_RS43265	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP87_RS43295	COG0084	hydrolase, TatD family'
HEP87_RS43320	COG2223	nitrite transmembrane transporter activity
HEP87_RS43330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP87_RS43340	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP87_RS43385	COG0330	HflC and HflK could
HEP87_RS43465	COG0402	S-adenosylhomocysteine deaminase activity
HEP87_RS43495	COG2226	methyltransferase
HEP87_RS43510	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HEP87_RS43520	COG4221	oxidoreductase activity
HEP87_RS43535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP87_RS43540	COG0254	rRNA binding
HEP87_RS43560	COG2197	response regulator
HEP87_RS43575	COG1309	transcriptional regulator
HEP87_RS43630	COG0542	response to heat
HEP87_RS43645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP87_RS43670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP87_RS43680	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HEP87_RS43695	COG1063	alcohol dehydrogenase
HEP87_RS43705	COG0745	RESPONSE REGULATOR receiver
HEP87_RS43715	COG0477	Major facilitator Superfamily
HEP87_RS43720	COG2124	cytochrome p450
HEP87_RS43770	COG2353	YceI-like domain
HEP87_RS43780	COG0765	amino acid transport
HEP87_RS43800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS43805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS43810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS43815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS43840	COG0395	ABC-type sugar transport system, permease component
HEP87_RS43845	COG1175	transmembrane transport
HEP87_RS43865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP87_RS43870	COG1309	transcriptional regulator
HEP87_RS43915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP87_RS43930	COG2986	histidine ammonia-lyase
HEP87_RS43995	COG3903	Transcriptional regulator
HEP87_RS43995	COG3629	intracellular signal transduction
HEP87_RS44010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP87_RS44050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP87_RS44090	COG3467	pyridoxamine 5'-phosphate
HEP87_RS44105	COG0477	Major facilitator Superfamily
HEP87_RS44135	COG0588	phosphoglycerate mutase activity
HEP87_RS44140	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP87_RS44145	COG0166	Belongs to the GPI family
HEP87_RS44160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP87_RS44195	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS44235	COG1175	transmembrane transport
HEP87_RS44245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP87_RS44250	COG1349	DNA-binding transcription factor activity
HEP87_RS44255	COG1486	melibiose metabolic process
HEP87_RS44265	COG3469	chitinase activity
HEP87_RS44330	COG3842	ATPase activity
HEP87_RS44335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP87_RS44340	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP87_RS44345	COG1177	transmembrane transport
HEP87_RS44355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP87_RS44370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP87_RS44375	COG3938	Belongs to the proline racemase family
HEP87_RS44395	COG1175	transmembrane transport
HEP87_RS44400	COG0395	ABC-type sugar transport system, permease component
HEP87_RS44405	COG0366	Alpha amylase catalytic
HEP87_RS44415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP87_RS44420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP87_RS44505	COG3511	phospholipase C
HEP87_RS44535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HEP87_RS44540	COG0477	Major facilitator Superfamily
HEP87_RS44550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP87_RS44560	COG3485	protocatechuate 3,4-dioxygenase
HEP87_RS44565	COG3485	protocatechuate 3,4-dioxygenase
HEP87_RS44585	COG1846	Transcriptional regulator
HEP87_RS44595	COG0714	Associated with various cellular activities
HEP87_RS44610	COG1793	dna ligase
HEP87_RS44675	COG1834	amidinotransferase
HEP87_RS44680	COG0488	(ABC) transporter
HEP87_RS44720	COG3268	Saccharopine dehydrogenase
HEP87_RS44725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP87_RS44730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS44735	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS44740	COG0183	Belongs to the thiolase family
HEP87_RS44745	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS44745	COG1024	Enoyl-CoA hydratase
HEP87_RS44750	COG0789	Transcriptional regulator
HEP87_RS44755	COG1113	amino acid transport
HEP87_RS44775	COG2936	dipeptidyl-peptidase activity
HEP87_RS44790	COG0488	(ABC) transporter
HEP87_RS44800	COG2183	response to ionizing radiation
HEP87_RS44820	COG1024	Enoyl-CoA hydratase
HEP87_RS44835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP87_RS44885	COG1134	teichoic acid transport
HEP87_RS44890	COG1562	ergosterol biosynthetic process
HEP87_RS44910	COG1657	PFAM Prenyltransferase squalene oxidase
HEP87_RS44925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEP87_RS44930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP87_RS44950	COG2365	Tyrosine phosphatase family
HEP87_RS44990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HEP87_RS45040	COG1063	alcohol dehydrogenase
HEP87_RS45045	COG0156	8-amino-7-oxononanoate synthase activity
HEP87_RS45050	COG0583	DNA-binding transcription factor activity
HEP87_RS45085	COG3958	Transketolase
HEP87_RS45090	COG3959	Transketolase, thiamine diphosphate binding domain
HEP87_RS45140	COG3033	Beta-eliminating lyase
HEP87_RS45160	COG1937	Protein conserved in bacteria
HEP87_RS45175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP87_RS45180	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP87_RS45200	COG3239	Fatty acid desaturase
HEP87_RS45210	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HEP87_RS45290	COG3485	protocatechuate 3,4-dioxygenase
HEP87_RS45295	COG1454	alcohol dehydrogenase
HEP87_RS45300	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEP87_RS45305	COG0351	phosphomethylpyrimidine kinase
HEP87_RS45390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP87_RS45425	COG0668	transmembrane transport
HEP87_RS45430	COG1024	Enoyl-CoA hydratase
HEP87_RS45445	COG2409	Drug exporters of the RND superfamily
HEP87_RS45450	COG1309	transcriptional regulator
HEP87_RS45465	COG0473	3-isopropylmalate dehydrogenase activity
HEP87_RS45475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP87_RS45490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP87_RS45505	COG3483	tryptophan 2,3-dioxygenase activity
HEP87_RS45520	COG0475	glutathione-regulated potassium exporter activity
HEP87_RS45540	COG2264	protein methyltransferase activity
HEP87_RS45580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP87_RS45585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP87_RS45590	COG0697	spore germination
HEP87_RS45595	COG1509	lysine 2,3-aminomutase activity
HEP87_RS45605	COG0579	oxidoreductase
HEP87_RS45655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HEP87_RS45670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HEP87_RS45695	COG0297	glycogen (starch) synthase activity
HEP87_RS45700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEP87_RS45720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP87_RS45725	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS45735	COG0701	Predicted permease
HEP87_RS45770	COG1609	Transcriptional regulator
HEP87_RS45780	COG1175	transmembrane transport
HEP87_RS45785	COG0395	ABC-type sugar transport system, permease component
HEP87_RS45810	COG2186	Transcriptional regulator
HEP87_RS45820	COG1129	ABC transporter
HEP87_RS45825	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP87_RS45830	COG4948	Mandelate Racemase Muconate Lactonizing
HEP87_RS45835	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS45875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP87_RS45910	COG0726	polysaccharide deacetylase
HEP87_RS45965	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS45980	COG1053	succinate dehydrogenase
HEP87_RS45985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEP87_RS46005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS46020	COG0667	Aldo Keto reductase
HEP87_RS46025	COG1376	ErfK ybiS ycfS ynhG family protein
HEP87_RS46080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP87_RS46105	COG1595	DNA-templated transcription, initiation
HEP87_RS46145	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HEP87_RS46150	COG0121	glutamine amidotransferase
HEP87_RS46155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP87_RS46160	COG3572	ergothioneine biosynthetic process
HEP87_RS46185	COG2268	Band 7 protein
HEP87_RS46200	COG1609	Transcriptional regulator
HEP87_RS46215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP87_RS46225	COG0242	peptide deformylase activity
HEP87_RS46295	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP87_RS46465	COG2318	DinB family
HEP87_RS46485	COG0789	Transcriptional regulator
HEP87_RS46490	COG0667	Aldo Keto reductase
HEP87_RS46535	COG0583	DNA-binding transcription factor activity
HEP87_RS46540	COG0477	Major facilitator Superfamily
HEP87_RS46580	COG1609	Transcriptional regulator
HEP87_RS46585	COG3537	Alpha-1,2-mannosidase
HEP87_RS46645	COG0561	phosphatase activity
HEP87_RS46725	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP87_RS46730	COG3396	Phenylacetate-CoA oxygenase
HEP87_RS46735	COG3460	Phenylacetate-CoA oxygenase
HEP87_RS46740	COG3396	Phenylacetate-CoA oxygenase
HEP87_RS46745	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS46765	COG2050	protein possibly involved in aromatic compounds catabolism
HEP87_RS46780	COG0531	amino acid
HEP87_RS46835	COG0477	Major facilitator Superfamily
HEP87_RS46845	COG2226	methyltransferase
HEP87_RS46865	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP87_RS46870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEP87_RS46870	COG1024	Enoyl-CoA hydratase
HEP87_RS46880	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEP87_RS46910	COG0375	protein maturation
HEP87_RS46915	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEP87_RS46925	COG0298	carbon dioxide binding
HEP87_RS46930	COG0409	Hydrogenase expression formation protein
HEP87_RS46935	COG0309	Hydrogenase expression formation protein (HypE)
HEP87_RS46965	COG1141	Ferredoxin
HEP87_RS46995	COG1174	glycine betaine transport
HEP87_RS47000	COG1174	glycine betaine transport
HEP87_RS47030	COG0517	IMP dehydrogenase activity
HEP87_RS47030	COG1125	glycine betaine transport
HEP87_RS47035	COG1556	Lactate utilization protein
HEP87_RS47045	COG0247	lactate metabolic process
HEP87_RS47055	COG3347	Dehydrogenase
HEP87_RS47055	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS47075	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP87_RS47080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP87_RS47100	COG1609	Transcriptional regulator
HEP87_RS47110	COG1595	DNA-templated transcription, initiation
HEP87_RS47115	COG1357	PFAM Pentapeptide repeats (8 copies)
HEP87_RS47125	COG1309	transcriptional regulator
HEP87_RS47135	COG2706	6-phosphogluconolactonase activity
HEP87_RS47185	COG2723	6-phospho-beta-galactosidase activity
HEP87_RS47190	COG0395	ABC-type sugar transport system, permease component
HEP87_RS47195	COG1175	transmembrane transport
HEP87_RS47200	COG2182	Extracellular solute-binding protein
HEP87_RS47225	COG2267	carboxylic ester hydrolase activity
HEP87_RS47235	COG1796	DNA polymerase
HEP87_RS47235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HEP87_RS47275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP87_RS47295	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS47335	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS47350	COG3321	synthase
HEP87_RS47350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP87_RS47380	COG0531	amino acid
HEP87_RS47420	COG2124	cytochrome p450
HEP87_RS47460	COG0596	Alpha beta hydrolase
HEP87_RS47500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP87_RS47540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP87_RS47570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS47585	COG4209	transmembrane transport
HEP87_RS47590	COG0395	ABC-type sugar transport system, permease component
HEP87_RS47600	COG1609	Transcriptional regulator
HEP87_RS47630	COG3832	glyoxalase III activity
HEP87_RS47675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP87_RS47675	COG2755	lipolytic protein G-D-S-L family
HEP87_RS47750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP87_RS47765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP87_RS47895	COG1846	Transcriptional regulator
HEP87_RS47895	COG1940	carbohydrate kinase activity
HEP87_RS47945	COG1595	DNA-templated transcription, initiation
HEP87_RS47995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP87_RS48025	COG0583	DNA-binding transcription factor activity
HEP87_RS48030	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS48035	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS48045	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS48085	COG0003	Pfam Anion-transporting ATPase
HEP87_RS48145	COG1984	allophanate hydrolase subunit 2
HEP87_RS48150	COG0477	Major facilitator Superfamily
HEP87_RS48155	COG4221	oxidoreductase activity
HEP87_RS48165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP87_RS48170	COG1802	Transcriptional regulator
HEP87_RS48250	COG0583	DNA-binding transcription factor activity
HEP87_RS48265	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS48410	COG1278	Cold shock
HEP87_RS48445	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP87_RS48450	COG0714	Associated with various cellular activities
HEP87_RS48475	COG1132	(ABC) transporter
HEP87_RS48485	COG0596	Alpha beta hydrolase
HEP87_RS48500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP87_RS48525	COG1175	transmembrane transport
HEP87_RS48530	COG0395	ABC-type sugar transport system, permease component
HEP87_RS48545	COG1072	(Pantothenic acid kinase))
HEP87_RS48565	COG2340	Cysteine-rich secretory protein family
HEP87_RS48610	COG3469	chitinase activity
HEP87_RS48620	COG3548	integral membrane protein
HEP87_RS48630	COG0667	Aldo Keto reductase
HEP87_RS48640	COG3537	Alpha-1,2-mannosidase
HEP87_RS48700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEP87_RS48705	COG0730	response to heat
HEP87_RS48710	COG1937	Protein conserved in bacteria
HEP87_RS48745	COG2378	regulation of single-species biofilm formation
HEP87_RS48750	COG4552	Acetyltransferase involved in intracellular survival and related
HEP87_RS48780	COG1175	transmembrane transport
HEP87_RS48785	COG0395	ABC-type sugar transport system, permease component
HEP87_RS48805	COG3345	alpha-galactosidase
HEP87_RS48815	COG0667	Aldo Keto reductase
HEP87_RS48840	COG3852	Histidine kinase
HEP87_RS48910	COG1131	(ABC) transporter
HEP87_RS48910	COG1716	ATPase activity
HEP87_RS48910	COG0842	Transport permease protein
HEP87_RS48940	COG0739	heme binding
HEP87_RS48960	COG0583	DNA-binding transcription factor activity
HEP87_RS48965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP87_RS49005	COG0395	ABC-type sugar transport system, permease component
HEP87_RS49015	COG1609	Transcriptional regulator
HEP87_RS49020	COG1335	isochorismatase
HEP87_RS49030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP87_RS49035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP87_RS49050	COG1595	DNA-templated transcription, initiation
HEP87_RS49080	COG5002	protein histidine kinase activity
HEP87_RS49100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP87_RS49110	COG1053	succinate dehydrogenase
HEP87_RS49125	COG2318	DinB family
HEP87_RS49135	COG2318	DinB family
HEP87_RS49175	COG0596	Alpha beta hydrolase
HEP87_RS49180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP87_RS49180	COG1017	nitric oxide dioxygenase activity
HEP87_RS49235	COG2197	response regulator
HEP87_RS49265	COG4191	Histidine kinase
HEP87_RS49275	COG2239	Acts as a magnesium transporter
HEP87_RS49320	COG2326	polyphosphate kinase activity
HEP87_RS49325	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HEP87_RS49330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP87_RS49355	COG0516	GMP reductase activity
HEP87_RS49355	COG0517	IMP dehydrogenase activity
HEP87_RS49375	COG0516	GMP reductase activity
HEP87_RS49375	COG0517	IMP dehydrogenase activity
HEP87_RS49440	COG1063	alcohol dehydrogenase
HEP87_RS49455	COG0531	amino acid
HEP87_RS49460	COG2235	arginine
HEP87_RS49465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP87_RS49480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEP87_RS49510	COG1309	transcriptional regulator
HEP87_RS49515	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS49535	COG1278	Cold shock
HEP87_RS49540	COG0513	Belongs to the DEAD box helicase family
HEP87_RS49715	COG3896	Chloramphenicol phosphotransferase-like protein
HEP87_RS49720	COG0583	DNA-binding transcription factor activity
HEP87_RS49735	COG2130	NADP-dependent
HEP87_RS49740	COG0789	Transcriptional regulator
HEP87_RS49805	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS49825	COG2267	carboxylic ester hydrolase activity
HEP87_RS49850	COG2814	Major facilitator Superfamily
HEP87_RS49880	COG1132	(ABC) transporter
HEP87_RS49895	COG2318	DinB family
HEP87_RS49920	COG2130	NADP-dependent
HEP87_RS49925	COG0789	Transcriptional regulator
HEP87_RS49930	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS49935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP87_RS49955	COG2264	protein methyltransferase activity
HEP87_RS49975	COG0583	DNA-binding transcription factor activity
HEP87_RS49985	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS49995	COG1846	Transcriptional regulator
HEP87_RS49995	COG1940	carbohydrate kinase activity
HEP87_RS50000	COG3345	alpha-galactosidase
HEP87_RS50010	COG3833	ABC-type maltose transport systems, permease component
HEP87_RS50035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS50045	COG1335	isochorismatase
HEP87_RS50055	COG0667	Aldo Keto reductase
HEP87_RS50060	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS50085	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS50160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP87_RS50225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEP87_RS50300	COG1278	Cold shock
HEP87_RS50360	COG3547	Transposase (IS116 IS110 IS902 family)
HEP87_RS50440	COG0454	-acetyltransferase
HEP87_RS50465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP87_RS50475	COG1063	alcohol dehydrogenase
HEP87_RS50505	COG0243	molybdopterin cofactor binding
HEP87_RS50530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP87_RS50540	COG2837	iron assimilation
HEP87_RS50680	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP87_RS50685	COG1129	ABC transporter
HEP87_RS50690	COG2208	phosphoserine phosphatase activity
HEP87_RS50740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP87_RS50790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP87_RS50805	COG1522	sequence-specific DNA binding
HEP87_RS50850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP87_RS50925	COG5640	endopeptidase activity
HEP87_RS51000	COG1082	Xylose isomerase domain protein TIM barrel
HEP87_RS51010	COG2084	Dehydrogenase
HEP87_RS51055	COG1136	(ABC) transporter
HEP87_RS51090	COG3511	phospholipase C
HEP87_RS51115	COG0531	amino acid
HEP87_RS51175	COG0726	polysaccharide deacetylase
HEP87_RS51270	COG2124	cytochrome p450
HEP87_RS51360	COG0165	Argininosuccinate lyase
HEP87_RS51380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP87_RS51385	COG0778	Nitroreductase
HEP87_RS51505	COG2267	carboxylic ester hydrolase activity
HEP87_RS51525	COG0531	amino acid
HEP87_RS51540	COG4221	oxidoreductase activity
HEP87_RS51565	COG3795	YCII-related domain
HEP87_RS51610	COG2124	cytochrome p450
HEP87_RS51620	COG1959	2 iron, 2 sulfur cluster binding
HEP87_RS51625	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS51635	COG4585	Histidine kinase
HEP87_RS51640	COG2197	response regulator
HEP87_RS51675	COG2197	response regulator
HEP87_RS51680	COG4585	Histidine kinase
HEP87_RS51720	COG0277	FAD linked oxidase domain protein
HEP87_RS51725	COG1024	Enoyl-CoA hydratase
HEP87_RS51750	COG2267	carboxylic ester hydrolase activity
HEP87_RS51765	COG0789	Transcriptional regulator
HEP87_RS51785	COG1902	pentaerythritol trinitrate reductase activity
HEP87_RS51785	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP87_RS51795	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS51800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP87_RS51880	COG1309	transcriptional regulator
HEP87_RS51915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP87_RS51925	COG1720	tRNA m6t6A37 methyltransferase activity
HEP87_RS51940	COG1595	DNA-templated transcription, initiation
HEP87_RS52025	COG0604	alcohol dehydrogenase
HEP87_RS52025	COG3321	synthase
HEP87_RS52065	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS52110	COG4977	sequence-specific DNA binding
HEP87_RS52230	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP87_RS52260	COG0436	Aminotransferase
HEP87_RS52275	COG0583	DNA-binding transcription factor activity
HEP87_RS52320	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS52325	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS52330	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS52335	COG1902	pentaerythritol trinitrate reductase activity
HEP87_RS52335	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP87_RS52340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP87_RS52345	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS52360	COG5441	Belongs to the UPF0261 family
HEP87_RS52485	COG1595	DNA-templated transcription, initiation
HEP87_RS52570	COG3547	Transposase (IS116 IS110 IS902 family)
HEP87_RS52610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP87_RS52640	COG0477	Major facilitator Superfamily
HEP87_RS52655	COG1024	Enoyl-CoA hydratase
HEP87_RS52690	COG2409	Drug exporters of the RND superfamily
HEP87_RS52705	COG2072	flavoprotein involved in K transport
HEP87_RS52710	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS52710	COG3347	Dehydrogenase
HEP87_RS52715	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS52725	COG2223	nitrite transmembrane transporter activity
HEP87_RS52750	COG0300	oxidoreductase activity
HEP87_RS52760	COG0778	Nitroreductase
HEP87_RS52765	COG0667	Aldo Keto reductase
HEP87_RS52775	COG3851	Histidine kinase
HEP87_RS52780	COG2197	response regulator
HEP87_RS52840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP87_RS52955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP87_RS52955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP87_RS52955	COG3321	synthase
HEP87_RS52955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP87_RS52955	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS53015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP87_RS53020	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS53025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP87_RS53035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP87_RS53050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP87_RS53060	COG0667	Aldo Keto reductase
HEP87_RS53105	COG0477	Major facilitator Superfamily
HEP87_RS53110	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HEP87_RS53175	COG1335	isochorismatase
HEP87_RS53180	COG3619	membrane
HEP87_RS53190	COG2259	Doxx family
HEP87_RS53255	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS53285	COG2850	peptidyl-arginine hydroxylation
HEP87_RS53310	COG2746	aminoglycoside 3-N-acetyltransferase activity
HEP87_RS53405	COG3387	PFAM Glycoside hydrolase 15-related
HEP87_RS53430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP87_RS53440	COG1595	DNA-templated transcription, initiation
HEP87_RS53500	COG1609	Transcriptional regulator
HEP87_RS53515	COG0395	ABC-type sugar transport system, permease component
HEP87_RS53545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS53575	COG1414	Transcriptional regulator
HEP87_RS53610	COG0655	NAD(P)H dehydrogenase (quinone) activity
HEP87_RS53700	COG1309	transcriptional regulator
HEP87_RS53705	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS53745	COG0163	prenyltransferase activity
HEP87_RS53785	COG1335	isochorismatase
HEP87_RS53845	COG0789	Transcriptional regulator
HEP87_RS53900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP87_RS53915	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS53930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP87_RS53930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP87_RS53970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEP87_RS53975	COG1070	Carbohydrate kinase
HEP87_RS53980	COG0698	ribose 5-phosphate isomerase
HEP87_RS53985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP87_RS53990	COG1129	ABC transporter
HEP87_RS53995	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP87_RS54000	COG1879	ABC-type sugar transport system periplasmic component
HEP87_RS54005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP87_RS54020	COG3629	intracellular signal transduction
HEP87_RS54020	COG3903	Transcriptional regulator
HEP87_RS54025	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS54040	COG1414	Transcriptional regulator
HEP87_RS54080	COG0247	lactate metabolic process
HEP87_RS54125	COG1073	alpha beta
HEP87_RS54160	COG2211	Major facilitator Superfamily
HEP87_RS54270	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS54285	COG1129	ABC transporter
HEP87_RS54310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP87_RS54325	COG4585	Histidine kinase
HEP87_RS54325	COG2203	Gaf domain
HEP87_RS54330	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP87_RS54335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP87_RS54345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HEP87_RS54350	COG0531	amino acid
HEP87_RS54370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP87_RS54390	COG4166	transmembrane transport
HEP87_RS54395	COG0601	transmembrane transport
HEP87_RS54410	COG4608	Belongs to the ABC transporter superfamily
HEP87_RS54440	COG4974	Belongs to the 'phage' integrase family
HEP87_RS54525	COG0477	Major facilitator Superfamily
HEP87_RS54535	COG0745	RESPONSE REGULATOR receiver
HEP87_RS54560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS54565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP87_RS54570	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS54610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP87_RS54615	COG0745	RESPONSE REGULATOR receiver
HEP87_RS54620	COG0747	negative chemotaxis
HEP87_RS54625	COG0601	transmembrane transport
HEP87_RS54630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP87_RS54665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP87_RS54700	COG2814	Major facilitator Superfamily
HEP87_RS54710	COG1053	succinate dehydrogenase
HEP87_RS54710	COG1053	succinate dehydrogenase
HEP87_RS54715	COG1301	dicarboxylic acid transport
HEP87_RS54720	COG2828	Protein conserved in bacteria
HEP87_RS54730	COG0583	DNA-binding transcription factor activity
HEP87_RS54735	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS54745	COG1960	acyl-CoA dehydrogenase activity
HEP87_RS54755	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS54760	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS54800	COG2080	2 iron, 2 sulfur cluster binding
HEP87_RS54805	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP87_RS54815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP87_RS54845	COG1902	pentaerythritol trinitrate reductase activity
HEP87_RS54855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS54915	COG0601	transmembrane transport
HEP87_RS54925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP87_RS54930	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS54935	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS54965	COG1012	belongs to the aldehyde dehydrogenase family
HEP87_RS54985	COG1595	DNA-templated transcription, initiation
HEP87_RS54995	COG1309	transcriptional regulator
HEP87_RS55000	COG1309	transcriptional regulator
HEP87_RS55005	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS55045	COG3284	Transcriptional regulator
HEP87_RS55085	COG1920	GTP binding
HEP87_RS55090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP87_RS55145	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEP87_RS55180	COG0596	Alpha beta hydrolase
HEP87_RS55190	COG0596	Alpha beta hydrolase
HEP87_RS55195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP87_RS55210	COG1024	Enoyl-CoA hydratase
HEP87_RS55220	COG0318	PFAM AMP-dependent synthetase and ligase
HEP87_RS55230	COG2301	Belongs to the HpcH HpaI aldolase family
HEP87_RS55235	COG2030	dehydratase
HEP87_RS55245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP87_RS55265	COG3572	ergothioneine biosynthetic process
HEP87_RS55280	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HEP87_RS55355	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HEP87_RS55360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HEP87_RS55365	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS55395	COG1733	regulation of RNA biosynthetic process
HEP87_RS55410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP87_RS55415	COG1920	GTP binding
HEP87_RS55430	COG1733	regulation of RNA biosynthetic process
HEP87_RS55435	COG0667	Aldo Keto reductase
HEP87_RS55445	COG0673	inositol 2-dehydrogenase activity
HEP87_RS55455	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEP87_RS55460	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HEP87_RS55460	COG0778	Nitroreductase
HEP87_RS55490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP87_RS55505	COG0583	DNA-binding transcription factor activity
HEP87_RS55515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP87_RS55520	COG1024	Enoyl-CoA hydratase
HEP87_RS55530	COG1024	Enoyl-CoA hydratase
HEP87_RS55535	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP87_RS55545	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS55645	COG3903	Transcriptional regulator
HEP87_RS55645	COG3629	intracellular signal transduction
HEP87_RS55680	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEP87_RS55795	COG3547	Transposase (IS116 IS110 IS902 family)
HEP87_RS55895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP87_RS55900	COG1028	Short-chain dehydrogenase reductase Sdr
HEP87_RS55935	COG1024	Enoyl-CoA hydratase
HEP87_RS55980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP87_RS55995	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEP87_RS56005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP87_RS56165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HEP87_RS56260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP87_RS56320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids