locus-tag class description FNV66_RS00080 ENOG4105KVH Transcriptional regulator FNV66_RS00175 ENOG4105CDU Replicative dna helicase FNV66_RS00180 ENOG4105K7N UPF0232 protein FNV66_RS00205 ENOG4107RB3 L-asparaginase FNV66_RS00375 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FNV66_RS00385 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FNV66_RS00490 ENOG4105C0B DNA polymerase III (alpha subunit) FNV66_RS00495 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV66_RS00620 ENOG4105C1B dTDP-glucose 4-6-dehydratase FNV66_RS00890 ENOG4105C1B dTDP-glucose 4-6-dehydratase FNV66_RS00915 ENOG4109066 lysm domain bon superfamily protein FNV66_RS01190 ENOG4107QJE Chromosome Partitioning Protein FNV66_RS01385 ENOG4105VEQ Cold shock protein FNV66_RS01505 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV66_RS01510 ENOG4105IIV Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) FNV66_RS01525 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS01560 ENOG4105CIR epoxide hydrolase FNV66_RS01615 ENOG4108YIQ Alpha beta hydrolase FNV66_RS01675 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV66_RS01805 ENOG41085W3 Transposase FNV66_RS01880 ENOG4108Z40 Transcriptional regulator FNV66_RS02050 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FNV66_RS02060 ENOG4105KVH Transcriptional regulator FNV66_RS02085 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV66_RS02170 ENOG4105CHH sulfate transporter FNV66_RS02180 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FNV66_RS02235 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV66_RS02275 ENOG4105K5X acetyltransferase FNV66_RS02350 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS02385 ENOG4105C9Q fumarate hydratase class II FNV66_RS02390 ENOG4105C6K Malic enzyme FNV66_RS02395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS02400 ENOG4107RCV ABC transporter, permease FNV66_RS02410 ENOG4107R13 MMPL domain protein FNV66_RS02420 ENOG4105ETX regulatoR FNV66_RS02425 ENOG4106F60 Histidine kinase FNV66_RS02480 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV66_RS02495 ENOG4105ENX hydrolase FNV66_RS02505 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FNV66_RS02515 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FNV66_RS02525 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FNV66_RS02540 ENOG4107RDB Major Facilitator FNV66_RS02565 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FNV66_RS02575 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV66_RS02580 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FNV66_RS02645 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FNV66_RS02685 ENOG4105BZU Histidine kinase FNV66_RS02690 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS02705 ENOG4105VEQ Cold shock protein FNV66_RS02720 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FNV66_RS02795 ENOG4105DWV Homoserine O-trans-acetylase FNV66_RS02810 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV66_RS02825 ENOG4107RSM transcriptional regulator FNV66_RS02830 ENOG4105CHR reductase FNV66_RS02840 ENOG4105NAE bifunctional deaminase-reductase domain protein FNV66_RS02855 ENOG4105MHT Transcriptional regulator, ARSR family FNV66_RS02865 ENOG4108YYQ gCN5-related N-acetyltransferase FNV66_RS02885 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS02920 ENOG4105CNT hydrolase family 2 FNV66_RS02925 ENOG4105CNT hydrolase family 2 FNV66_RS02940 ENOG4105DSG hydrolase family 43 FNV66_RS02960 ENOG4105CHR reductase FNV66_RS03065 ENOG4105DA5 (ABC) transporter FNV66_RS03150 ENOG4105RKW reductase (By FNV66_RS03160 ENOG4108IND Tetr family transcriptional regulator FNV66_RS03210 ENOG4105KNA -acetyltransferase FNV66_RS03230 ENOG4105F44 Two component transcriptional regulator, winged helix family FNV66_RS03235 ENOG4106F60 Histidine kinase FNV66_RS03275 ENOG4108XG2 Histidine kinase FNV66_RS03280 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS03285 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FNV66_RS03310 ENOG4105ECP epimerase FNV66_RS03315 ENOG4108KPJ rna polymerase sigma factor FNV66_RS03330 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FNV66_RS03340 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS03345 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FNV66_RS03380 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FNV66_RS03385 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FNV66_RS03420 ENOG4105CPQ Dehydrogenase FNV66_RS03425 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FNV66_RS03495 ENOG4105D7V transposase FNV66_RS03505 ENOG4105EKQ RNA-directed DNA polymerase FNV66_RS03595 ENOG4105VBF alkaline shock protein FNV66_RS03640 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth FNV66_RS03655 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) FNV66_RS03665 ENOG4107ETC gas vesicle protein FNV66_RS03670 ENOG4108XNA Gas vesicle FNV66_RS03680 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FNV66_RS03700 ENOG4105CBC glutamate synthase FNV66_RS03705 ENOG4105C7K acetolactate synthase FNV66_RS03710 ENOG4107R6F Alpha Beta Hydrolase Fold protein FNV66_RS03720 ENOG4105WN5 stage II sporulation protein FNV66_RS03730 ENOG4105CQB FAD linked oxidase domain protein FNV66_RS03735 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS03750 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) FNV66_RS03765 ENOG4105E0A ABC, transporter FNV66_RS03770 ENOG4105EHG Permease protein FNV66_RS03780 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS03785 ENOG4105WQI isochorismatase FNV66_RS03860 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS03875 ENOG4107QPD alcohol dehydrogenase FNV66_RS03895 ENOG4105EW9 transcriptional regulator AsnC family FNV66_RS03910 ENOG4107S5I aldo keto reductase FNV66_RS03940 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV66_RS03955 ENOG4105CWX Alpha-1,2-mannosidase FNV66_RS03970 ENOG4105XPP Protein of unknown function (DUF1275) FNV66_RS03975 ENOG4106NZI LysR family Transcriptional regulator FNV66_RS03980 ENOG4105EHZ conserved protein UCP016719 FNV66_RS03985 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FNV66_RS04000 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FNV66_RS04010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV66_RS04030 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FNV66_RS04040 ENOG4105EW6 flavin reductase domain protein, FMN-binding FNV66_RS04050 ENOG4105NTD Inherit from COG: Hydrolase FNV66_RS04055 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS04065 ENOG4105C5I Dehydrogenase FNV66_RS04090 ENOG4105CHR reductase FNV66_RS04120 ENOG4105CS1 NAD(P)H quinone oxidoreductase FNV66_RS04130 ENOG4105KVH Transcriptional regulator FNV66_RS04145 ENOG41082JN Transcriptional regulator FNV66_RS04165 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS04170 ENOG4105D2B acyl-CoA dehydrogenase FNV66_RS04180 ENOG4105DYW oxidoreductase FNV66_RS04190 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS04200 ENOG4106YT9 Enoyl-CoA hydratase FNV66_RS04205 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS04215 ENOG4107SET aldo keto reductase FNV66_RS04220 ENOG4105CY0 Metallo-Beta-Lactamase FNV66_RS04245 ENOG4108UHU Aldolase FNV66_RS04255 ENOG4105CXK mandelate racemase muconate lactonizing FNV66_RS04280 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FNV66_RS04290 ENOG4105EX0 alpha-galactosidase FNV66_RS04295 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FNV66_RS04315 ENOG4107QWG 2-Nitropropane dioxygenase FNV66_RS04365 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FNV66_RS04380 ENOG4105KF0 sporulation and cell division protein, SsgA FNV66_RS04395 ENOG4106NZI LysR family Transcriptional regulator FNV66_RS04405 ENOG4108Q9V regulatoR FNV66_RS04420 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FNV66_RS04435 ENOG4105R1U AraC Family Transcriptional Regulator FNV66_RS04440 ENOG4105EU0 Major facilitator Superfamily FNV66_RS04470 ENOG4105C26 Dehydrogenase FNV66_RS04485 ENOG4105D7V transposase FNV66_RS04495 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS04505 ENOG4105D7V transposase FNV66_RS04640 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV66_RS04670 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FNV66_RS04695 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV66_RS04745 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FNV66_RS04750 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FNV66_RS04775 ENOG4105CHR reductase FNV66_RS04780 ENOG4105FDP GntR family transcriptional regulator FNV66_RS04800 ENOG4105E2D ec 3.2.1.52 FNV66_RS04805 ENOG4105D7V transposase FNV66_RS04810 ENOG4107QWR cellulase (EC 3.2.1.4) FNV66_RS04865 ENOG4105ESN nucleotide-binding protein FNV66_RS04875 ENOG4108PA7 Methyltransferase FNV66_RS04915 ENOG4106UDK Cellulose-binding, family II FNV66_RS04975 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV66_RS04980 ENOG4105CHR reductase FNV66_RS04990 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV66_RS05030 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS05075 ENOG4107RSM transcriptional regulator FNV66_RS05090 ENOG4105CHR reductase FNV66_RS05115 ENOG4107S9F NmrA family FNV66_RS05125 ENOG4105C54 Major Facilitator superfamily FNV66_RS05130 ENOG4105EXC Acyl-transferase FNV66_RS05175 ENOG4105ETS cytosine purines uracil thiamine allantoin FNV66_RS05200 ENOG4105E2A Dehydrogenase FNV66_RS05210 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS05225 ENOG4105F0H myo-inositol catabolism protein FNV66_RS05235 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FNV66_RS05260 ENOG4105JQZ Methyltransferase FNV66_RS05290 ENOG4105DFW ABC transporter FNV66_RS05300 ENOG4105DFW ABC transporter FNV66_RS05305 ENOG4105C2J ABC transporter FNV66_RS05310 ENOG4108HWW ABC transporter FNV66_RS05320 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV66_RS05325 ENOG4108K8U Glycerol operon regulatory protein FNV66_RS05355 ENOG4107YCR Transcriptional regulator, ARSR family FNV66_RS05360 ENOG4105HS2 Arsenate reductase FNV66_RS05365 ENOG4107R33 ppx gppa phosphatase FNV66_RS05375 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS05420 ENOG4106A3M Cytochrome p-450 FNV66_RS05495 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV66_RS05500 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FNV66_RS05575 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FNV66_RS05585 ENOG4105DQ4 alcohol dehydrogenase FNV66_RS05615 ENOG4107RTD sua5 ycio yrdc ywlc family protein FNV66_RS05625 ENOG4105CFG Acts as a chaperone (By similarity) FNV66_RS05630 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FNV66_RS05645 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FNV66_RS05660 ENOG4107HP6 Transcriptional regulator FNV66_RS05665 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase FNV66_RS05670 ENOG4105C6Z Gluconate FNV66_RS05675 ENOG4105EQX glucarate dehydratase FNV66_RS05690 ENOG4105C19 ABC transporter FNV66_RS05695 ENOG4105BZU Histidine kinase FNV66_RS05700 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS05705 ENOG4105J7D transcriptional regulator FNV66_RS05710 ENOG4105CHR reductase FNV66_RS05720 ENOG4108KPJ rna polymerase sigma factor FNV66_RS05775 ENOG4105D2S major facilitator superfamily FNV66_RS05790 ENOG4105JSC dimethylmenaquinone methyltransferase FNV66_RS05800 ENOG4108QBF Transcriptional regulator FNV66_RS05820 ENOG4107AQZ Membrane FNV66_RS05835 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV66_RS06000 ENOG4105E2R ROK family FNV66_RS06080 ENOG4105NAE bifunctional deaminase-reductase domain protein FNV66_RS06100 ENOG4105BZU Histidine kinase FNV66_RS06105 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS06160 ENOG4108V1U phospholipid-binding protein FNV66_RS06175 ENOG4105CHR reductase FNV66_RS06180 ENOG4107YCY Transcriptional regulator FNV66_RS06185 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS06190 ENOG4105D2B acyl-CoA dehydrogenase FNV66_RS06195 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS06200 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS06205 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FNV66_RS06210 ENOG4105CGU Enoyl-CoA hydratase FNV66_RS06215 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS06220 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS06225 ENOG4105CHR reductase FNV66_RS06240 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS06245 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS06265 ENOG4108IV0 ABC, transporter FNV66_RS06270 ENOG4105C0Z ABC transporter FNV66_RS06295 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS06305 ENOG4105D2B acyl-CoA dehydrogenase FNV66_RS06310 ENOG4105EBR Carboxylesterase FNV66_RS06315 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS06330 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS06335 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS06355 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FNV66_RS06370 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS06380 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS06390 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS06400 ENOG4108RZE Tetr family transcriptional regulator FNV66_RS06405 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV66_RS06440 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FNV66_RS06445 ENOG4105C26 Dehydrogenase FNV66_RS06460 ENOG4105CHR reductase FNV66_RS06470 ENOG4105DVW rieske (2Fe-2S) FNV66_RS06480 ENOG4105CI2 imidazolone-5-propionate hydrolase FNV66_RS06490 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS06510 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS06515 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS06530 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase FNV66_RS06555 ENOG4108RZE Tetr family transcriptional regulator FNV66_RS06560 ENOG4105BZU Histidine kinase FNV66_RS06565 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS06585 ENOG4105EQ0 Major Facilitator superfamily FNV66_RS06635 ENOG4105DNP FAD linked oxidase domain protein FNV66_RS06650 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FNV66_RS06660 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) FNV66_RS06665 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FNV66_RS06695 ENOG4107R39 (ABC) transporter FNV66_RS06730 ENOG4105D7V transposase FNV66_RS06755 ENOG4105E8G Major facilitator Superfamily FNV66_RS06775 ENOG4107VIJ nudix hydrolase FNV66_RS06790 ENOG4105D7V transposase FNV66_RS06900 ENOG4105D9P serine threonine protein kinase FNV66_RS06915 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FNV66_RS06930 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FNV66_RS06945 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV66_RS07185 ENOG4105D5G Transposase FNV66_RS07195 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV66_RS07305 ENOG4105VEQ Cold shock protein FNV66_RS07350 ENOG4105EKQ RNA-directed DNA polymerase FNV66_RS07370 ENOG4105F5W AtP-binding protein FNV66_RS07375 ENOG4106IJN integrase catalytic domain-containing protein FNV66_RS07420 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS07425 ENOG4105EGE secreted protein FNV66_RS07440 ENOG4105EX0 alpha-galactosidase FNV66_RS07450 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FNV66_RS07460 ENOG4105E2R ROK family FNV66_RS07475 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FNV66_RS07530 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV66_RS07545 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FNV66_RS07570 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV66_RS07595 ENOG4107T8T UPF0173 metal-dependent hydrolase FNV66_RS07645 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FNV66_RS07650 ENOG4105CHR reductase FNV66_RS07895 ENOG410836F Transposase FNV66_RS08065 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FNV66_RS08070 ENOG4105DQE DNA ligase FNV66_RS08120 ENOG4105F9F transposase FNV66_RS08160 ENOG4105DQ6 Transposase FNV66_RS08195 ENOG4105CVR type I restriction-modification system FNV66_RS08260 ENOG4105BZP glycoside hydrolase 15-related FNV66_RS08305 ENOG4105EYF MMPL domain protein FNV66_RS08320 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS08330 ENOG4105D7V transposase FNV66_RS08335 ENOG4108RS6 transposase FNV66_RS08360 ENOG4105VMP Transcriptional regulator FNV66_RS08425 ENOG4108RWI nicotinamidase FNV66_RS08435 ENOG4105D5G Transposase FNV66_RS08475 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FNV66_RS08515 ENOG4108YZ9 Urea amidohydrolase subunit gamma FNV66_RS08530 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FNV66_RS08535 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FNV66_RS08545 ENOG4105VU5 Resolvase domain-containing protein FNV66_RS08570 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV66_RS08585 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein FNV66_RS08625 ENOG4107QQG Dehydrogenase FNV66_RS08635 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FNV66_RS08640 ENOG4108Z6Z Transcriptional regulator FNV66_RS08645 ENOG4105EMU Dehydrogenase FNV66_RS08660 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FNV66_RS08710 ENOG4105Q33 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency FNV66_RS08820 ENOG4105EFZ amidohydrolase FNV66_RS08870 ENOG4105C0D helicase FNV66_RS08920 ENOG4108YYH Nadph-dependent fmn reductase FNV66_RS09000 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FNV66_RS09040 ENOG4108RFG Tetr family transcriptional regulator FNV66_RS09055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV66_RS09095 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FNV66_RS09100 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FNV66_RS09105 ENOG4108XHQ (2Fe-2S)-binding domain protein FNV66_RS09125 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FNV66_RS09210 ENOG4107SVN transposase FNV66_RS09230 ENOG4105CIR epoxide hydrolase FNV66_RS09235 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FNV66_RS09240 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FNV66_RS09270 ENOG4105BZU Histidine kinase FNV66_RS09335 ENOG4105IDI abc transporter atp-binding protein FNV66_RS09350 ENOG4105E7U AraC family transcriptional regulator FNV66_RS09360 ENOG4105CPC Aldo Keto reductase FNV66_RS09365 ENOG4108M0I Transcriptional regulator FNV66_RS09380 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FNV66_RS09385 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FNV66_RS09390 ENOG410841Q phosphoesterase PA-phosphatase related protein FNV66_RS09405 ENOG4107S5I aldo keto reductase FNV66_RS09415 ENOG4105C26 Dehydrogenase FNV66_RS09420 ENOG4105CHP RNA polymerase FNV66_RS09435 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FNV66_RS09450 ENOG4105FBW Monooxygenase FNV66_RS09465 ENOG4105CGD Nad-dependent epimerase dehydratase FNV66_RS09470 ENOG4105CVP deoxyribo-dipyrimidine photolyase FNV66_RS09550 ENOG4107QTZ amino acid FNV66_RS09555 ENOG4105DKQ ROK family FNV66_RS09580 ENOG4105EX0 alpha-galactosidase FNV66_RS09585 ENOG4105C5X domain protein FNV66_RS09605 ENOG4105CPC Aldo Keto reductase FNV66_RS09635 ENOG4105CAQ asparagine synthetase FNV66_RS09640 ENOG4105CBC glutamate synthase FNV66_RS09645 ENOG4105CEU Arginine dihydrolase FNV66_RS09660 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FNV66_RS09715 ENOG4107SM8 Adenylate Guanylate cyclase FNV66_RS09755 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS09790 ENOG4105X7H acyl-CoA dehydrogenase FNV66_RS09815 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS09820 ENOG4108EU3 peptide transport system, permease FNV66_RS09830 ENOG4105DEF Extracellular solute-binding protein, family 5 FNV66_RS09855 ENOG4107QI1 Mate efflux family protein FNV66_RS09860 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS09865 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FNV66_RS09880 ENOG4105C26 Dehydrogenase FNV66_RS09885 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FNV66_RS09890 ENOG4105DH8 myo-inositol catabolism FNV66_RS09900 ENOG4105EDK PfkB domain protein FNV66_RS09910 ENOG4105CNN ABC, transporter FNV66_RS09915 ENOG4105C2J ABC transporter FNV66_RS09930 ENOG4105C7K acetolactate synthase FNV66_RS09935 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FNV66_RS09940 ENOG4107R5W Monooxygenase FNV66_RS09945 ENOG4105DVW rieske (2Fe-2S) FNV66_RS09950 ENOG4105CHR reductase FNV66_RS09960 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS09965 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS09975 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS09980 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FNV66_RS09990 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS09995 ENOG4105CYC Transferase FNV66_RS10015 ENOG4107YCY Transcriptional regulator FNV66_RS10020 ENOG4105CHR reductase FNV66_RS10030 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FNV66_RS10035 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS10055 ENOG4105CPQ Dehydrogenase FNV66_RS10065 ENOG4105D3W isochorismatase FNV66_RS10135 ENOG4105CT3 Monooxygenase FNV66_RS10160 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FNV66_RS10165 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FNV66_RS10170 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FNV66_RS10180 ENOG4105C0X amino acid FNV66_RS10230 ENOG4108JA1 polyketide synthase FNV66_RS10240 ENOG4105ENX hydrolase FNV66_RS10285 ENOG4108J5G 6-phosphogluconate dehydrogenase FNV66_RS10300 ENOG4105E66 phosphoriboisomerase A FNV66_RS10305 ENOG4105CMT Dihydroxyacetone kinase FNV66_RS10310 ENOG4108UTZ Dihydroxyacetone kinase FNV66_RS10325 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV66_RS10355 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV66_RS10360 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FNV66_RS10405 ENOG4105I82 acetyl xylan esterase FNV66_RS10420 ENOG4105FDP GntR family transcriptional regulator FNV66_RS10430 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS10435 ENOG4105CG3 alpha amylase, catalytic region FNV66_RS10440 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV66_RS10450 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV66_RS10495 ENOG4105ERH Fumarylacetoacetate hydrolase FNV66_RS10510 ENOG4105CHP RNA polymerase FNV66_RS10520 ENOG4105GRZ Ycii-related protein FNV66_RS10530 ENOG4108UYE Lactoylglutathione lyase FNV66_RS10535 ENOG4105CHR reductase FNV66_RS10545 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FNV66_RS10555 ENOG4105DZ1 carboxypeptidase FNV66_RS10560 ENOG4107JC6 Membrane FNV66_RS10565 ENOG4105CSV Glutaminase FNV66_RS10570 ENOG4108IJ0 Aspartate ammonia-lyase FNV66_RS10590 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FNV66_RS10600 ENOG4105KJJ Uncharacterized ACR, COG1993 FNV66_RS10605 ENOG41083YR Protein CrcB homolog FNV66_RS10630 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FNV66_RS10640 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS10655 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) FNV66_RS10670 ENOG4108KC1 acyl-Coa dehydrogenase FNV66_RS10680 ENOG4105EDW glycosyl transferase, family 39 FNV66_RS10720 ENOG4107R8N Glycosyl transferase, family 2 FNV66_RS10735 ENOG4105QVC MOSC domain-containing protein FNV66_RS10755 ENOG4105MVE transcriptional regulator FNV66_RS10780 ENOG4107R34 abc transporter permease protein FNV66_RS10785 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV66_RS10810 ENOG4105DKQ ROK family FNV66_RS10820 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) FNV66_RS10845 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FNV66_RS10850 ENOG4105E98 transcriptional regulator DeoR family FNV66_RS10855 ENOG4105CWX Alpha-1,2-mannosidase FNV66_RS10860 ENOG4108IJ8 ABC transporter FNV66_RS10865 ENOG4105E90 ABC transporter FNV66_RS10885 ENOG4105GWZ Roadblock lc7 family protein FNV66_RS10905 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FNV66_RS10915 ENOG4107P5I polyketide synthase FNV66_RS10925 ENOG4107RCI amp-dependent synthetase and ligase FNV66_RS10935 ENOG4108YIQ Alpha beta hydrolase FNV66_RS10940 ENOG4108MRH transcriptional regulatory protein FNV66_RS10945 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FNV66_RS10950 ENOG4105D7T ABC transporter FNV66_RS10955 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FNV66_RS10985 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FNV66_RS10990 ENOG4105C4M (Ubiquinol oxidase) subunit I FNV66_RS11045 ENOG4105BZP glycoside hydrolase 15-related FNV66_RS11065 ENOG4106UW1 Major Facilitator superfamily FNV66_RS11090 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS11095 ENOG4105BZU Histidine kinase FNV66_RS11110 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FNV66_RS11115 ENOG4107PP3 Acetylornithine deacetylase FNV66_RS11120 ENOG4105I1F Resistance protein FNV66_RS11165 ENOG4105EX0 alpha-galactosidase FNV66_RS11175 ENOG41060NJ transcriptional regulator FNV66_RS11195 ENOG4105C10 Electron transfer flavoprotein FNV66_RS11220 ENOG4105PSQ Acyl-transferase FNV66_RS11245 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FNV66_RS11330 ENOG4105YVS arsR family transcriptional regulator FNV66_RS11335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV66_RS11350 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS11355 ENOG4105BZU Histidine kinase FNV66_RS11370 ENOG4105DBE peroxidase FNV66_RS11375 ENOG410650H (LipO)protein FNV66_RS11380 ENOG4105CRK lysyL-tRNA synthetase FNV66_RS11390 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FNV66_RS11430 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FNV66_RS11435 ENOG4105DEG Vwa containing coxe family protein FNV66_RS11465 ENOG4105EBM Alpha Beta Hydrolase Fold protein FNV66_RS11470 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FNV66_RS11475 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FNV66_RS11485 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FNV66_RS11540 ENOG4105C7W Xanthine dehydrogenase FNV66_RS11545 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FNV66_RS11550 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FNV66_RS11565 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FNV66_RS11600 ENOG4108RQS Two component transcriptional regulator (Winged helix family FNV66_RS11635 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FNV66_RS11670 ENOG4105V9V Short-chain dehydrogenase reductase Sdr FNV66_RS11690 ENOG4105CHR reductase FNV66_RS11720 ENOG4107S5I aldo keto reductase FNV66_RS11725 ENOG4105EMU Dehydrogenase FNV66_RS11745 ENOG4105C1J atp-dependent rna helicase FNV66_RS11755 ENOG4107ZED Uncharacterised protein family UPF0047 FNV66_RS11760 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FNV66_RS11765 ENOG4105E2Y ABC, transporter FNV66_RS11775 ENOG4105H3G oxidoreductase FNV66_RS11785 ENOG4105BZ1 (ABC) transporter FNV66_RS11795 ENOG4105CK2 sodium dicarboxylate symporter FNV66_RS11815 ENOG4105BZ1 (ABC) transporter FNV66_RS11840 ENOG4105C29 acyl-CoA thioesterase FNV66_RS11850 ENOG4105GWZ Roadblock lc7 family protein FNV66_RS11880 ENOG4105BZU Histidine kinase FNV66_RS11920 ENOG4105C0D helicase FNV66_RS11940 ENOG4105C93 Xylose Isomerase FNV66_RS11950 ENOG4105E2R ROK family FNV66_RS11960 ENOG4107SCA Formamidase (EC 3.5.1.49) FNV66_RS11970 ENOG4107RR1 TRANSCRIPTIONal FNV66_RS11975 ENOG4105C26 Dehydrogenase FNV66_RS12020 ENOG4108UGD Serine Threonine protein kinase FNV66_RS12045 ENOG4105D2B acyl-CoA dehydrogenase FNV66_RS12050 ENOG4105D2B acyl-CoA dehydrogenase FNV66_RS12055 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV66_RS12065 ENOG4105C3M thioredoxin reductase FNV66_RS12070 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) FNV66_RS12080 ENOG4105C26 Dehydrogenase FNV66_RS12095 ENOG41065KQ synthase FNV66_RS12100 ENOG4106A3M Cytochrome p-450 FNV66_RS12120 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FNV66_RS12130 ENOG4105F1K Glutamine amidotransferase FNV66_RS12135 ENOG4105CTQ phosphohexokinase FNV66_RS12160 ENOG4108HRK Histidine kinase FNV66_RS12175 ENOG4108NEV two component transcriptional regulator, LytTR family FNV66_RS12185 ENOG4105CIK Amidinotransferase FNV66_RS12190 ENOG4105C8Y Acetylornithine aminotransferase FNV66_RS12200 ENOG410600Z Regulatory protein MarR FNV66_RS12210 ENOG4105KVH Transcriptional regulator FNV66_RS12225 ENOG4107R9S Malate synthase FNV66_RS12235 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FNV66_RS12265 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FNV66_RS12275 ENOG4105CQM Urea amidohydrolase subunit alpha FNV66_RS12280 ENOG4105KI2 Urea amidohydrolase subunit beta FNV66_RS12285 ENOG4108YZ9 Urea amidohydrolase subunit gamma FNV66_RS12335 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FNV66_RS12340 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FNV66_RS12345 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FNV66_RS12385 ENOG4105FBW Monooxygenase FNV66_RS12390 ENOG4108R6G acetyltransferase FNV66_RS12430 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FNV66_RS12440 ENOG4105C83 adenylosuccinate lyase FNV66_RS12445 ENOG4108VCA G U mismatch-specific DNA glycosylase FNV66_RS12465 ENOG4105BZU Histidine kinase FNV66_RS12470 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS12475 ENOG4105DKQ ROK family FNV66_RS12480 ENOG4105FDP GntR family transcriptional regulator FNV66_RS12485 ENOG4108KPJ rna polymerase sigma factor FNV66_RS12490 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FNV66_RS12500 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV66_RS12535 ENOG4107RSM transcriptional regulator FNV66_RS12550 ENOG4105EYH Exonuclease FNV66_RS12555 ENOG4107RFY SbcCD D subunit FNV66_RS12560 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FNV66_RS12580 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS12590 ENOG4105X7H acyl-CoA dehydrogenase FNV66_RS12605 ENOG4105K4P CoA-binding domain protein FNV66_RS12615 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV66_RS12640 ENOG4105CSR polyphosphate kinase 2 FNV66_RS12670 ENOG4108UW5 maltose o-acetyltransferase FNV66_RS12675 ENOG4108Z0R Transferase FNV66_RS12705 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS12740 ENOG4105CVK Glutamate decarboxylase FNV66_RS12755 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FNV66_RS12770 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS12795 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FNV66_RS12820 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FNV66_RS12835 ENOG4105DEN Luciferase family FNV66_RS12845 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FNV66_RS12850 ENOG4105EP9 oxidoreductase FNV66_RS12870 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FNV66_RS12875 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FNV66_RS12880 ENOG4105CHR reductase FNV66_RS12915 ENOG4105EJQ L-serine dehydratase FNV66_RS12920 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FNV66_RS12925 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FNV66_RS12960 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FNV66_RS12980 ENOG4108IJ7 Glycine betaine FNV66_RS13000 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FNV66_RS13010 ENOG4105DVW rieske (2Fe-2S) FNV66_RS13015 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FNV66_RS13025 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FNV66_RS13065 ENOG4108Q5Y Membrane FNV66_RS13070 ENOG4105CSW GntR family transcriptional regulator FNV66_RS13105 ENOG4105JAB phenazine biosynthesis protein, phzf family FNV66_RS13135 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FNV66_RS13145 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FNV66_RS13165 ENOG4108UW8 fha domain-containing protein FNV66_RS13215 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FNV66_RS13230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV66_RS13235 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FNV66_RS13245 ENOG4105E09 nadh pyrophosphatase FNV66_RS13250 ENOG4108UQS dipeptidase FNV66_RS13260 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV66_RS13265 ENOG4105BZU Histidine kinase FNV66_RS13270 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV66_RS13275 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV66_RS13295 ENOG4105GWZ Roadblock lc7 family protein FNV66_RS13340 ENOG4105CFM UPF0317 protein FNV66_RS13345 ENOG4105E7W lamb ycsf family protein FNV66_RS13350 ENOG4105P4J Allophanate hydrolase, subunit 1 FNV66_RS13355 ENOG4107R7A Allophanate hydrolase subunit 2 FNV66_RS13360 ENOG41090WU lipolytic protein G-D-S-L family FNV66_RS13365 ENOG4108MJN Glycosyl Transferase FNV66_RS13380 ENOG4105JXB ankyrin repeat-containing protein FNV66_RS13395 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV66_RS13410 ENOG4105DEU major facilitator superfamily FNV66_RS13415 ENOG4105Q70 FNV66_RS13425 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FNV66_RS13435 ENOG4105EW9 transcriptional regulator AsnC family FNV66_RS13460 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS13470 ENOG4107Z3H Transcriptional regulator, TetR family FNV66_RS13490 ENOG4107S03 uridine kinase FNV66_RS13515 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FNV66_RS13520 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase FNV66_RS13525 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FNV66_RS13530 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FNV66_RS13545 ENOG4105E2R ROK family FNV66_RS13550 ENOG4106UW1 Major Facilitator superfamily FNV66_RS13565 ENOG4105C2W permease FNV66_RS13610 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 FNV66_RS13615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS13625 ENOG4105F38 ABC transporter, permease FNV66_RS13635 ENOG4108TZY GntR Family Transcriptional Regulator FNV66_RS13645 ENOG4105CUB amino acid FNV66_RS13665 ENOG4105DKT Transcriptional regulator FNV66_RS13670 ENOG4105DJV ribulose-phosphate 3-epimerase FNV66_RS13680 ENOG4107QN2 dihydrolipoyl dehydrogenase FNV66_RS13700 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FNV66_RS13715 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FNV66_RS13730 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FNV66_RS13740 ENOG4105SKN orotidine 5''-phosphate decarboxylase FNV66_RS13745 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FNV66_RS13750 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FNV66_RS13755 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FNV66_RS13765 ENOG4105CD3 dihydroorotase FNV66_RS13770 ENOG4105CXT aspartate transcarbamylase FNV66_RS13775 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FNV66_RS13785 ENOG410803B Involved in the transcription termination process (By similarity) FNV66_RS13790 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FNV66_RS13795 ENOG4105DC7 peptidase M24 FNV66_RS13805 ENOG4105D49 3-dehydroquinate synthase FNV66_RS13810 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FNV66_RS13815 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FNV66_RS13820 ENOG4105E2X shikimate dehydrogenase FNV66_RS13825 ENOG4105HHA aminodeoxychorismate lyase FNV66_RS13830 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FNV66_RS13835 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FNV66_RS13855 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FNV66_RS13870 ENOG4105CJ1 ABC, transporter FNV66_RS13880 ENOG4105BZU Histidine kinase FNV66_RS13885 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS13890 ENOG4105CUT histidyl-tRNA synthetase FNV66_RS13900 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) FNV66_RS13905 ENOG4105C99 atpase involved in dna repair FNV66_RS13910 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FNV66_RS13915 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FNV66_RS13920 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FNV66_RS13925 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FNV66_RS13935 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FNV66_RS13940 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FNV66_RS13945 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FNV66_RS13950 ENOG4105CDY transcriptional regulatory protein FNV66_RS13955 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FNV66_RS13960 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FNV66_RS13975 ENOG4105E2K Glycosyl transferase (Group 1 FNV66_RS14010 ENOG4105C22 threonyL-tRNA synthetase FNV66_RS14025 ENOG4108IRC dna polymerase iii FNV66_RS14045 ENOG4105EKC FNV66_RS14055 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FNV66_RS14060 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FNV66_RS14080 ENOG4105KF0 sporulation and cell division protein, SsgA FNV66_RS14110 ENOG4105F0I Aminotransferase FNV66_RS14175 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FNV66_RS14180 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FNV66_RS14195 ENOG4105D01 (LipO)protein FNV66_RS14200 ENOG4108UMI ABC transporter, permease FNV66_RS14205 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS14240 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS14245 ENOG4105C57 major facilitator superfamily FNV66_RS14250 ENOG4105RJZ Transcriptional regulator FNV66_RS14260 ENOG4105CH7 arginosuccinase FNV66_RS14265 ENOG4105CDH Citrulline--aspartate ligase FNV66_RS14285 ENOG4105BZU Histidine kinase FNV66_RS14290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS14320 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FNV66_RS14325 ENOG4105C8Y Acetylornithine aminotransferase FNV66_RS14330 ENOG4105CAS nag kinase FNV66_RS14335 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FNV66_RS14340 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FNV66_RS14360 ENOG4105VUF Transcriptional regulator FNV66_RS14390 ENOG4105T38 integral membrane protein FNV66_RS14400 ENOG4105F32 YngK protein FNV66_RS14430 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FNV66_RS14435 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FNV66_RS14440 ENOG4105BZU Histidine kinase FNV66_RS14445 ENOG4108RWN rrna methyltransferase FNV66_RS14450 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FNV66_RS14455 ENOG41084BS 50S ribosomal protein L35 FNV66_RS14460 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FNV66_RS14515 ENOG4105C26 Dehydrogenase FNV66_RS14520 ENOG4105C5F glutamine synthetase FNV66_RS14530 ENOG4108Z86 Glutamine amidotransferase FNV66_RS14570 ENOG4108HQS Glycine betaine FNV66_RS14575 ENOG4108IJ7 Glycine betaine FNV66_RS14580 ENOG4105HFS 5'-3' exonuclease FNV66_RS14825 ENOG4105D3G Pseudouridine synthase FNV66_RS14855 ENOG4105MKU Transcriptional regulator FNV66_RS14895 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FNV66_RS14900 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FNV66_RS14930 ENOG4108V1T peptidylprolyl cis-trans isomerase FNV66_RS14935 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) FNV66_RS14945 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS14950 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FNV66_RS14955 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FNV66_RS14965 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) FNV66_RS14970 ENOG4105E5F proteasome FNV66_RS14975 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) FNV66_RS15005 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS15015 ENOG4108J59 Extracellular solute-binding protein, family 5 FNV66_RS15020 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FNV66_RS15025 ENOG4105C3R Methionine synthase FNV66_RS15030 ENOG4108K8U Glycerol operon regulatory protein FNV66_RS15035 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV66_RS15040 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV66_RS15050 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FNV66_RS15060 ENOG4105C2J ABC transporter FNV66_RS15070 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FNV66_RS15075 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FNV66_RS15080 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FNV66_RS15085 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FNV66_RS15090 ENOG4105JXH GntR family transcriptional regulator FNV66_RS15115 ENOG4105C8N cysteinyl-tRNA synthetase FNV66_RS15135 ENOG4105D7N magnesium and cobalt transport protein CorA FNV66_RS15145 ENOG4105DYW oxidoreductase FNV66_RS15150 ENOG4105CPC Aldo Keto reductase FNV66_RS15170 ENOG4105S2J secreted protein FNV66_RS15180 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FNV66_RS15195 ENOG4105CD8 aminopeptidase N FNV66_RS15200 ENOG4105K5B UPF0225 protein FNV66_RS15205 ENOG4105C6F GntR Family Transcriptional Regulator FNV66_RS15210 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FNV66_RS15215 ENOG4105C6Z Gluconate FNV66_RS15220 ENOG4105CHR reductase FNV66_RS15225 ENOG4105CPQ Dehydrogenase FNV66_RS15250 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein FNV66_RS15260 ENOG4105PTV Nudix Hydrolase FNV66_RS15265 ENOG4105VG5 Membrane FNV66_RS15285 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS15290 ENOG4108IG5 Transcriptional regulator FNV66_RS15295 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS15305 ENOG4105EHZ conserved protein UCP016719 FNV66_RS15325 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FNV66_RS15330 ENOG4108Z4X TRANSCRIPTIONal FNV66_RS15350 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS15360 ENOG4108ZHR arsR family transcriptional regulator FNV66_RS15365 ENOG4107Y9U Membrane FNV66_RS15390 ENOG4105D4T Citrate transporter FNV66_RS15395 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FNV66_RS15400 ENOG4108SGK Tetr family transcriptional regulator FNV66_RS15410 ENOG4105F1J Homogentisate 1,2-dioxygenase FNV66_RS15445 ENOG4105RNG membrane FNV66_RS15450 ENOG4105K6V RNA polymerase FNV66_RS15465 ENOG41061MD high-affinity nickel-transporter FNV66_RS15470 ENOG4105D9P serine threonine protein kinase FNV66_RS15475 ENOG4108TCJ secreted hydrolase FNV66_RS15500 ENOG4107BJW polysaccharide deacetylase FNV66_RS15525 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FNV66_RS15565 ENOG4108Z2K Cupin 2, conserved barrel domain protein FNV66_RS15570 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FNV66_RS15575 ENOG4105C0B DNA polymerase III (alpha subunit) FNV66_RS15590 ENOG4106NMR serine protease FNV66_RS15610 ENOG4105CDA abc transporter atp-binding protein FNV66_RS15625 ENOG4105EAB amino acid AbC transporter FNV66_RS15635 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FNV66_RS15640 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS15645 ENOG4105C57 major facilitator superfamily FNV66_RS15655 ENOG410841Q phosphoesterase PA-phosphatase related protein FNV66_RS15665 ENOG4105BZ9 Cytochrome C oxidase, subunit I FNV66_RS15695 ENOG4105C2J ABC transporter FNV66_RS15700 ENOG4108IV0 ABC, transporter FNV66_RS15725 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FNV66_RS15735 ENOG4105CAT Cytidine monophosphate kinase FNV66_RS15775 ENOG410756H nucleotidyltransferase FNV66_RS15780 ENOG41065RQ ADP-ribosylation crystallin J1 FNV66_RS15790 ENOG4105FE9 pseudouridine synthase FNV66_RS15795 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FNV66_RS15800 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FNV66_RS15815 ENOG4105DCF alanine dehydrogenase FNV66_RS15825 ENOG4108YZ4 nudix hydrolase FNV66_RS15830 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FNV66_RS15835 ENOG4105BZP glycoside hydrolase 15-related FNV66_RS15860 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FNV66_RS15865 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FNV66_RS15885 ENOG4105E0A ABC, transporter FNV66_RS15890 ENOG4105TVJ transport system, permease FNV66_RS15895 ENOG4105DQ5 transport system permease protein FNV66_RS15900 ENOG4105DSU hydrolase FNV66_RS15935 ENOG4108VX5 3-methyladenine DNA glycosylase FNV66_RS15945 ENOG4108V1U phospholipid-binding protein FNV66_RS15965 ENOG4105DKW ABC transporter FNV66_RS15980 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS15990 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FNV66_RS15995 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FNV66_RS16005 ENOG4105IDI abc transporter atp-binding protein FNV66_RS16015 ENOG4105EAC phosphoserine phosphatase FNV66_RS16035 ENOG4107YCY Transcriptional regulator FNV66_RS16045 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FNV66_RS16050 ENOG4105CHR reductase FNV66_RS16065 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FNV66_RS16085 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FNV66_RS16090 ENOG4107QN1 sodium solute FNV66_RS16110 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F FNV66_RS16160 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FNV66_RS16175 ENOG4105BZP glycoside hydrolase 15-related FNV66_RS16205 ENOG4105VBF alkaline shock protein FNV66_RS16225 ENOG4105C5H ABC transporter FNV66_RS16255 ENOG4107W7X Aldolase FNV66_RS16275 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FNV66_RS16280 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FNV66_RS16285 ENOG4105CTK cobaltochelatase, cobn subunit FNV66_RS16295 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FNV66_RS16300 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FNV66_RS16315 ENOG4105CIA precorrin-4 C(11)-methyltransferase FNV66_RS16325 ENOG4105E4R Precorrin-3B C17-methyltransferase FNV66_RS16330 ENOG41081F0 Precorrin-8x methylmutase FNV66_RS16335 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FNV66_RS16360 ENOG4105EAD ABC transporter FNV66_RS16365 ENOG4105CT1 (ABC) transporter FNV66_RS16370 ENOG4105C5R Aminotransferase FNV66_RS16375 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase FNV66_RS16380 ENOG4108JPW Aminotransferase FNV66_RS16385 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FNV66_RS16390 ENOG4105EV8 ectoine hydroxylase FNV66_RS16395 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FNV66_RS16420 ENOG4107HP6 Transcriptional regulator FNV66_RS16430 ENOG4105CJN penicillin-binding protein FNV66_RS16435 ENOG4105C7N Xanthine uracil vitamin C permease FNV66_RS16440 ENOG4105NAF rna polymerase sigma factor FNV66_RS16455 ENOG4108J21 pectate lyase FNV66_RS16500 ENOG4108J20 pectate lyase FNV66_RS16505 ENOG4107TDE lipolytic protein G-D-S-L family FNV66_RS16510 ENOG4107T3P ABC, transporter FNV66_RS16515 ENOG4105E4I Glycoside hydrolase family 28 FNV66_RS16545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV66_RS16550 ENOG4105DRR Transcriptional regulator, GntR family FNV66_RS16575 ENOG4105E9Z Nad-dependent epimerase dehydratase FNV66_RS16580 ENOG4105E98 transcriptional regulator DeoR family FNV66_RS16600 ENOG4105CPQ Dehydrogenase FNV66_RS16610 ENOG4105XEA Tetr family transcriptional regulator FNV66_RS16625 ENOG4107XBN GntR Family Transcriptional Regulator FNV66_RS16670 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV66_RS16675 ENOG4105EEM helicase FNV66_RS16690 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FNV66_RS16695 ENOG4108RFG Tetr family transcriptional regulator FNV66_RS16700 ENOG410814C multidrug resistance protein FNV66_RS16715 ENOG4105VG1 fes assembly suf system protein FNV66_RS16720 ENOG4108UNV SUF system FeS assembly protein, NifU family FNV66_RS16725 ENOG4105C9B Cysteine desulfurase FNV66_RS16730 ENOG4105C3K feS assembly ATPase SufC FNV66_RS16740 ENOG4105JRK feS assembly protein SufD FNV66_RS16755 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FNV66_RS16760 ENOG4105CJ1 ABC, transporter FNV66_RS16785 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FNV66_RS16795 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FNV66_RS16810 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) FNV66_RS16815 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FNV66_RS16820 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component FNV66_RS16830 ENOG4105CG3 alpha amylase, catalytic region FNV66_RS16835 ENOG4107T3P ABC, transporter FNV66_RS16840 ENOG4105U3E Transcriptional regulator FNV66_RS16845 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV66_RS16860 ENOG4107QP8 phosphohexose isomerase FNV66_RS16880 ENOG4105CP7 Triose-phosphate isomerase FNV66_RS16885 ENOG4105BZA Phosphoglycerate kinase FNV66_RS16890 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FNV66_RS16900 ENOG4105CIE May be required for sporulation (By similarity) FNV66_RS16905 ENOG4105CHW UPF0052 protein FNV66_RS16910 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FNV66_RS16915 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FNV66_RS16930 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS16940 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FNV66_RS16955 ENOG4107R0W ABC transporter FNV66_RS16960 ENOG4105E5Q amino acid AbC transporter FNV66_RS16970 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FNV66_RS16975 ENOG4105CSH Transporter FNV66_RS17000 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FNV66_RS17005 ENOG4105BZU Histidine kinase FNV66_RS17010 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FNV66_RS17015 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FNV66_RS17035 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FNV66_RS17045 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS17050 ENOG4105D7N magnesium and cobalt transport protein CorA FNV66_RS17080 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV66_RS17090 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV66_RS17135 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FNV66_RS17165 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FNV66_RS17170 ENOG4105DRR Transcriptional regulator, GntR family FNV66_RS17185 ENOG4105D9G High-affinity FNV66_RS17215 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FNV66_RS17235 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS17240 ENOG4105CQ7 ATP-dependent helicase FNV66_RS17280 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) FNV66_RS17290 ENOG4105C32 Amino acid ABC transporter (Permease) FNV66_RS17295 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FNV66_RS17300 ENOG4105C0Z ABC transporter FNV66_RS17305 ENOG4108IV0 ABC, transporter FNV66_RS17340 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FNV66_RS17360 ENOG4108ZXC Two component transcriptional regulator, luxr family FNV66_RS17365 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FNV66_RS17370 ENOG41063TF transcriptional regulator (AraC FNV66_RS17395 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FNV66_RS17400 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FNV66_RS17405 ENOG41060WC Enoyl-CoA hydratase FNV66_RS17420 ENOG4105EA8 2-Nitropropane dioxygenase FNV66_RS17430 ENOG4105F2C Acetyl-CoA acetyltransferase FNV66_RS17435 ENOG4108RZE Tetr family transcriptional regulator FNV66_RS17445 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS17450 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS17455 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FNV66_RS17460 ENOG41090B9 response to stress FNV66_RS17465 ENOG4105MUA Resistance protein FNV66_RS17480 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV66_RS17495 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV66_RS17505 ENOG4105CBC glutamate synthase FNV66_RS17515 ENOG41065RQ ADP-ribosylation crystallin J1 FNV66_RS17535 ENOG4108RVA ribokinase FNV66_RS17540 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FNV66_RS17545 ENOG4105CI0 Citrate lyase FNV66_RS17550 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FNV66_RS17560 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FNV66_RS17565 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FNV66_RS17575 ENOG4105DK0 Indole-3-glycerol phosphate synthase FNV66_RS17600 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FNV66_RS17620 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FNV66_RS17625 ENOG4108176 endoribonuclease L-psp FNV66_RS17630 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FNV66_RS17635 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FNV66_RS17645 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FNV66_RS17650 ENOG4105CIH Imidazole acetol-phosphate transaminase FNV66_RS17655 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FNV66_RS17675 ENOG4108Z66 YbaK ebsC protein FNV66_RS17705 ENOG4105C0B DNA polymerase III (alpha subunit) FNV66_RS17760 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FNV66_RS17770 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FNV66_RS17775 ENOG4107VQS DivIVA family FNV66_RS17785 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FNV66_RS17790 ENOG4105DFA alanine racemase domain protein FNV66_RS17795 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FNV66_RS17800 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FNV66_RS17810 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FNV66_RS17820 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FNV66_RS17825 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FNV66_RS17835 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FNV66_RS17840 ENOG4105CJN penicillin-binding protein FNV66_RS17850 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FNV66_RS17860 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FNV66_RS17880 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FNV66_RS17890 ENOG4105CDA abc transporter atp-binding protein FNV66_RS17900 ENOG4107Z3H Transcriptional regulator, TetR family FNV66_RS17910 ENOG4105EWK phytoene FNV66_RS17925 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FNV66_RS17955 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FNV66_RS17965 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FNV66_RS17975 ENOG4108UQY Iron-storage protein FNV66_RS17985 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FNV66_RS18005 ENOG4105CTQ phosphohexokinase FNV66_RS18010 ENOG4108Q9V regulatoR FNV66_RS18015 ENOG4105ENE Histidine kinase FNV66_RS18040 ENOG4105DKQ ROK family FNV66_RS18050 ENOG4105D0U Arsenite-activated ATPase (ArsA) FNV66_RS18085 ENOG4105UQX Mate efflux family protein FNV66_RS18130 ENOG4105C9B Cysteine desulfurase FNV66_RS18135 ENOG4108I0Q anthranilate phosphoribosyltransferase FNV66_RS18140 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FNV66_RS18145 ENOG4107EUI c reductase, iron-sulfur FNV66_RS18150 ENOG4107UDY cytochrome C FNV66_RS18155 ENOG4105CCU oxidase (Subunit III) FNV66_RS18165 ENOG4107UBC ErfK ybiS ycfS ynhG family protein FNV66_RS18170 ENOG4105MCD Part of cytochrome c oxidase, its function is FNV66_RS18175 ENOG4105BZ9 Cytochrome C oxidase, subunit I FNV66_RS18180 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FNV66_RS18190 ENOG4107T4Z adenosine kinase FNV66_RS18210 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FNV66_RS18215 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS18240 ENOG4105DXX methyltransferase FNV66_RS18245 ENOG4105C0H protease FNV66_RS18255 ENOG4108YZT Adenosylcobinamide kinase FNV66_RS18265 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FNV66_RS18270 ENOG4105CRK lysyL-tRNA synthetase FNV66_RS18285 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FNV66_RS18290 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FNV66_RS18315 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FNV66_RS18345 ENOG4105I4A GCN5-related N-acetyltransferase FNV66_RS18365 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FNV66_RS18370 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FNV66_RS18390 ENOG4105C5F glutamine synthetase FNV66_RS18400 ENOG4105D0M Protease HtpX homolog FNV66_RS18430 ENOG4108222 arsenate reductase FNV66_RS18435 ENOG4106SPC secreted protein FNV66_RS18440 ENOG4107R5B glutamine synthetase FNV66_RS18445 ENOG4107NHD transcriptional regulator FNV66_RS18460 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS18490 ENOG41060BG Tetr family transcriptional regulator FNV66_RS18530 ENOG4105EG2 ABC transporter, permease FNV66_RS18535 ENOG4105CG3 alpha amylase, catalytic region FNV66_RS18540 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS18550 ENOG4107RSM transcriptional regulator FNV66_RS18555 ENOG4105FDR Membrane FNV66_RS18560 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FNV66_RS18565 ENOG4105FBN Acid phosphatase FNV66_RS18605 ENOG4105C5F glutamine synthetase FNV66_RS18610 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FNV66_RS18615 ENOG41081JD Transcriptional regulator FNV66_RS18635 ENOG4105C4K Nad synthetase FNV66_RS18640 ENOG4105F27 Major Facilitator FNV66_RS18655 ENOG4105C57 major facilitator superfamily FNV66_RS18660 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FNV66_RS18680 ENOG4107XZ0 Peptidase M50 FNV66_RS18735 ENOG410650H (LipO)protein FNV66_RS18740 ENOG4105DBE peroxidase FNV66_RS18750 ENOG4106A0S FNV66_RS18755 ENOG4105C8T Leucyl-tRNA synthetase FNV66_RS18765 ENOG4105CIK Amidinotransferase FNV66_RS18775 ENOG4107S1E Beta-lactamase FNV66_RS18780 ENOG4105C2C drug resistance transporter, Bcr CflA FNV66_RS18805 ENOG4105C19 ABC transporter FNV66_RS18810 ENOG4105CPC Aldo Keto reductase FNV66_RS18820 ENOG4108VGI doxx family FNV66_RS18835 ENOG4105GCF PGAM FNV66_RS18845 ENOG4105CHR reductase FNV66_RS18860 ENOG4106NZI LysR family Transcriptional regulator FNV66_RS18885 ENOG4105CY3 ABC transporter, permease FNV66_RS18970 ENOG4105E7U AraC family transcriptional regulator FNV66_RS18990 ENOG4107XFJ UPF0246 protein FNV66_RS18995 ENOG4108UHU Aldolase FNV66_RS19000 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV66_RS19020 ENOG4105EGD dinuclear metal center protein, YbgI family FNV66_RS19040 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FNV66_RS19055 ENOG4108M15 ABC transporter FNV66_RS19065 ENOG4105BZU Histidine kinase FNV66_RS19095 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS19110 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FNV66_RS19120 ENOG4105DYW oxidoreductase FNV66_RS19140 ENOG4107QVI Methyltransferase, type 11 FNV66_RS19145 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FNV66_RS19150 ENOG4108SGK Tetr family transcriptional regulator FNV66_RS19185 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase FNV66_RS19210 ENOG4105BZ1 (ABC) transporter FNV66_RS19230 ENOG4105XPP Protein of unknown function (DUF1275) FNV66_RS19255 ENOG4105F2C Acetyl-CoA acetyltransferase FNV66_RS19260 ENOG4106A3M Cytochrome p-450 FNV66_RS19275 ENOG4105CSH Transporter FNV66_RS19360 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FNV66_RS19365 ENOG4105D3W isochorismatase FNV66_RS19370 ENOG41080V3 Major Facilitator superfamily FNV66_RS19390 ENOG4105KVH Transcriptional regulator FNV66_RS19495 ENOG4105BZ4 penicillin-binding protein FNV66_RS19510 ENOG4105DAX Pfam:DUF2983 FNV66_RS19555 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FNV66_RS19560 ENOG4105EYW Ion transport protein FNV66_RS19585 ENOG4105CPC Aldo Keto reductase FNV66_RS19590 ENOG4105VUF Transcriptional regulator FNV66_RS19620 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV66_RS19625 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FNV66_RS19645 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FNV66_RS19655 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV66_RS19660 ENOG4108R86 Transcriptional regulator FNV66_RS19675 ENOG4106KE4 Dehydrogenase FNV66_RS19680 ENOG4105DUM transcriptional regulator, lysR family FNV66_RS19685 ENOG4105NGS secreted protein FNV66_RS19690 ENOG4105EXN Sulfate transport protein CysZ FNV66_RS19705 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV66_RS19710 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FNV66_RS19740 ENOG4105DFW ABC transporter FNV66_RS19750 ENOG4108HWW ABC transporter FNV66_RS19755 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FNV66_RS19760 ENOG4105CIH Imidazole acetol-phosphate transaminase FNV66_RS19795 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV66_RS19825 ENOG4108YIQ Alpha beta hydrolase FNV66_RS19870 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase FNV66_RS19880 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FNV66_RS19890 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FNV66_RS19895 ENOG41069M3 Transcriptional regulator FNV66_RS19925 ENOG41073B4 coagulation factor 5 8 type domain-containing protein FNV66_RS20000 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS20005 ENOG4105D8K carboxyl transferase FNV66_RS20010 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FNV66_RS20015 ENOG4105DFF Rod shape-determining protein mreb FNV66_RS20060 ENOG4105C32 Amino acid ABC transporter (Permease) FNV66_RS20070 ENOG4108IV0 ABC, transporter FNV66_RS20075 ENOG4105C0Z ABC transporter FNV66_RS20080 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS20130 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV66_RS20135 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FNV66_RS20145 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FNV66_RS20155 ENOG4107GZ4 SanA protein FNV66_RS20215 ENOG4107QZF nitrite reductase NADPH large subunit FNV66_RS20225 ENOG4108XFH Transcriptional regulator FNV66_RS20230 ENOG4105CHR reductase FNV66_RS20235 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV66_RS20245 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV66_RS20270 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FNV66_RS20275 ENOG4105E2R ROK family FNV66_RS20340 ENOG4105CPC Aldo Keto reductase FNV66_RS20350 ENOG4108SGK Tetr family transcriptional regulator FNV66_RS20355 ENOG4105E1F short-chain dehydrogenase reductase FNV66_RS20360 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FNV66_RS20365 ENOG4105DSE periplasmic solute binding protein FNV66_RS20370 ENOG4105FDK ABC transporter FNV66_RS20385 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FNV66_RS20390 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FNV66_RS20410 ENOG4108762 serine threonine protein kinase FNV66_RS20445 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FNV66_RS20450 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS20455 ENOG4105BZU Histidine kinase FNV66_RS20460 ENOG4105CJ1 ABC, transporter FNV66_RS20475 ENOG4105JXH GntR family transcriptional regulator FNV66_RS20480 ENOG4105DEF Extracellular solute-binding protein, family 5 FNV66_RS20490 ENOG4105C3U ABC transporter FNV66_RS20495 ENOG4108JQ7 (ABC) transporter FNV66_RS20500 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV66_RS20515 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FNV66_RS20520 ENOG4105D4Y metalloprotease FNV66_RS20570 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FNV66_RS20590 ENOG4105MSB protein, conserved in bacteria FNV66_RS20600 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FNV66_RS20625 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FNV66_RS20630 ENOG4107YU2 histidine triad (hIT) protein FNV66_RS20635 ENOG4107RE3 peptidase, S41 FNV66_RS20655 ENOG4107QWG 2-Nitropropane dioxygenase FNV66_RS20660 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FNV66_RS20665 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FNV66_RS20690 ENOG4105BZU Histidine kinase FNV66_RS20695 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FNV66_RS20705 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FNV66_RS20710 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FNV66_RS20735 ENOG4105KQC Competence protein FNV66_RS20740 ENOG4105EPR degv family FNV66_RS20750 ENOG4105C8T Leucyl-tRNA synthetase FNV66_RS20760 ENOG4107QIZ NADH dehydrogenase FNV66_RS20800 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV66_RS20815 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FNV66_RS20830 ENOG4105D0M Protease HtpX homolog FNV66_RS20845 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FNV66_RS20855 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FNV66_RS20860 ENOG4105CG5 Glycosyl transferase (Group 1 FNV66_RS20865 ENOG4107SJB teichoic acid biosynthesis FNV66_RS20870 ENOG4107SJB teichoic acid biosynthesis FNV66_RS20880 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FNV66_RS20885 ENOG4105K46 50S ribosomal protein l27 FNV66_RS20890 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FNV66_RS20895 ENOG4105C03 ribonuclease FNV66_RS20950 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV66_RS20955 ENOG41082YX Transcriptional regulator, arsr family FNV66_RS20960 ENOG41089UC methyltransferase, type 11 FNV66_RS20970 ENOG4105C57 major facilitator superfamily FNV66_RS21000 ENOG4105CNI cell division protein FtsW FNV66_RS21005 ENOG4105CJN penicillin-binding protein FNV66_RS21020 ENOG4105DFF Rod shape-determining protein mreb FNV66_RS21025 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FNV66_RS21035 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FNV66_RS21040 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FNV66_RS21050 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FNV66_RS21055 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FNV66_RS21060 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FNV66_RS21065 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FNV66_RS21095 ENOG4108TGC Acyltransferase FNV66_RS21125 ENOG4105C85 amino acid FNV66_RS21145 ENOG4105E2R ROK family FNV66_RS21155 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FNV66_RS21160 ENOG4105E2Y ABC, transporter FNV66_RS21175 ENOG4105C85 amino acid FNV66_RS21180 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FNV66_RS21185 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV66_RS21195 ENOG4105MC2 DSBA oxidoreductase FNV66_RS21230 ENOG4108UYE Lactoylglutathione lyase FNV66_RS21310 ENOG4107SCK Monooxygenase FNV66_RS21335 ENOG4108JJB ABC transporter FNV66_RS21360 ENOG4105D8X mechanosensitive ion channel FNV66_RS21395 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component FNV66_RS21400 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FNV66_RS21405 ENOG4105F8D glycoside hydrolase family 4 FNV66_RS21420 ENOG4105CT1 (ABC) transporter FNV66_RS21450 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FNV66_RS21455 ENOG4108Z18 K06886 hemoglobin FNV66_RS21495 ENOG4107ZF2 Phosphatase FNV66_RS21500 ENOG4108QV3 biosynthesis protein FNV66_RS21520 ENOG4105D3Q Sugar transferase FNV66_RS21580 ENOG4105C30 Nad-dependent epimerase dehydratase FNV66_RS21685 ENOG4105VHU single-stranded DNA-binding protein FNV66_RS21745 ENOG4105S2J secreted protein FNV66_RS21785 ENOG4105C26 Dehydrogenase FNV66_RS21790 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FNV66_RS21795 ENOG4105DH8 myo-inositol catabolism FNV66_RS21805 ENOG4105EDK PfkB domain protein FNV66_RS21810 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FNV66_RS21830 ENOG4107R13 MMPL domain protein FNV66_RS21860 ENOG4105C7H Helicase, RecD TraA family FNV66_RS21875 ENOG4105C2J ABC transporter FNV66_RS21880 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FNV66_RS21885 ENOG4108RVA ribokinase FNV66_RS21890 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FNV66_RS21915 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS21920 ENOG410645S MarR family Transcriptional regulator FNV66_RS21930 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FNV66_RS21935 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FNV66_RS21940 ENOG4105D17 glycoside hydrolase, family 3 domain protein FNV66_RS21980 ENOG4105EDW glycosyl transferase, family 39 FNV66_RS21985 ENOG4108K8S endonuclease I FNV66_RS21990 ENOG4105C7K acetolactate synthase FNV66_RS22000 ENOG4105CK7 Sodium proline symporter FNV66_RS22010 ENOG4108XFF FNV66_RS22020 ENOG4105C29 acyl-CoA thioesterase FNV66_RS22040 ENOG4107QX3 carboxylase FNV66_RS22050 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FNV66_RS22055 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS22090 ENOG4105DY8 decarboxylase FNV66_RS22095 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FNV66_RS22105 ENOG4105DUU IucA IucC family protein FNV66_RS22110 ENOG4105E2D ec 3.2.1.52 FNV66_RS22130 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FNV66_RS22150 ENOG4105ECQ AraC Family Transcriptional Regulator FNV66_RS22155 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FNV66_RS22175 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS22190 ENOG4105DRS transport system, permease FNV66_RS22205 ENOG4108NNZ chitinase FNV66_RS22210 ENOG410804D Sensor Signal Transduction Histidine Kinase FNV66_RS22215 ENOG4108RQS Two component transcriptional regulator (Winged helix family FNV66_RS22240 ENOG4105CVJ phosphoglycerate mutase FNV66_RS22285 ENOG4105BZU Histidine kinase FNV66_RS22290 ENOG4105DEN Luciferase family FNV66_RS22305 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FNV66_RS22310 ENOG4105DV0 amidase (EC 3.5.1.4 FNV66_RS22350 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS22365 ENOG4105DFM M18 family aminopeptidase FNV66_RS22385 ENOG4105J5T Amp-dependent synthetase and ligase FNV66_RS22395 ENOG4108M1A Chitin-binding protein FNV66_RS22425 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) FNV66_RS22450 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FNV66_RS22460 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS22470 ENOG4105MWK D-amino acid dehydrogenase, small subunit FNV66_RS22475 ENOG4105FDP GntR family transcriptional regulator FNV66_RS22490 ENOG4105D9R oxidoreductase FNV66_RS22495 ENOG41090KN UPF0303 protein FNV66_RS22505 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FNV66_RS22525 ENOG4108U4N (sortase) family FNV66_RS22535 ENOG4105CVA phosphate FNV66_RS22555 ENOG4105NI8 Cytosine-specific methyltransferase FNV66_RS22585 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FNV66_RS22625 ENOG4107Y2X deaminase FNV66_RS22660 ENOG41067TZ transcriptional regulator, MarR family FNV66_RS22685 ENOG4107QNK )-transporter FNV66_RS22690 ENOG4106BRA Membrane FNV66_RS22705 ENOG4105CJ1 ABC, transporter FNV66_RS22720 ENOG4105BZ4 penicillin-binding protein FNV66_RS22750 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FNV66_RS22760 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FNV66_RS22790 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein FNV66_RS22825 ENOG4105C85 amino acid FNV66_RS22835 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FNV66_RS22845 ENOG4108RWI nicotinamidase FNV66_RS22875 ENOG4105KF0 sporulation and cell division protein, SsgA FNV66_RS22880 ENOG4105CQB FAD linked oxidase domain protein FNV66_RS22890 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FNV66_RS22900 ENOG4105E90 ABC transporter FNV66_RS22920 ENOG41063PX domain protein FNV66_RS22925 ENOG4105DTQ mandelate racemase muconate lactonizing FNV66_RS22935 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FNV66_RS22955 ENOG4105CUB amino acid FNV66_RS23010 ENOG4105E2D ec 3.2.1.52 FNV66_RS23025 ENOG4107T3P ABC, transporter FNV66_RS23035 ENOG4108UJU UPF0301 protein FNV66_RS23040 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FNV66_RS23045 ENOG4108426 dNA-binding protein FNV66_RS23055 ENOG4105EEM helicase FNV66_RS23085 ENOG4105DQQ Major facilitator superfamily MFS_1 FNV66_RS23105 ENOG4105EMY transcriptional regulator FNV66_RS23130 ENOG4105CJQ hydrolase, family 31 FNV66_RS23140 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV66_RS23160 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FNV66_RS23165 ENOG4105CN1 protease FNV66_RS23175 ENOG4105CAK Cell division ATP-binding protein ftsE FNV66_RS23190 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FNV66_RS23195 ENOG4108QVN serine threonine protein kinase FNV66_RS23200 ENOG4108UGD Serine Threonine protein kinase FNV66_RS23225 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FNV66_RS23230 ENOG4107SJB teichoic acid biosynthesis FNV66_RS23235 ENOG4107SJB teichoic acid biosynthesis FNV66_RS23240 ENOG4105K64 Glycosyl transferase, family 2 FNV66_RS23255 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV66_RS23260 ENOG4105K56 Transcriptional regulator FNV66_RS23275 ENOG4105K64 Glycosyl transferase, family 2 FNV66_RS23300 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS23325 ENOG4105EY8 ABC transporter FNV66_RS23330 ENOG4105CG5 Glycosyl transferase (Group 1 FNV66_RS23335 ENOG4107SJB teichoic acid biosynthesis FNV66_RS23345 ENOG4105C7I Dehydrogenase FNV66_RS23370 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FNV66_RS23380 ENOG4105T0Z Conserved Protein FNV66_RS23385 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS23390 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea FNV66_RS23400 ENOG4105G3P Lipoprotein lpqB FNV66_RS23405 ENOG4105BZU Histidine kinase FNV66_RS23410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS23415 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FNV66_RS23430 ENOG4108WQ6 secreted protein FNV66_RS23435 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FNV66_RS23475 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FNV66_RS23485 ENOG4105EIP mannose-6-phosphate isomerase FNV66_RS23495 ENOG4105W49 UPF0434 protein FNV66_RS23500 ENOG4107QKV phosphomannomutase FNV66_RS23525 ENOG4106BQ7 Glycosyl Transferase FNV66_RS23530 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV66_RS23545 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) FNV66_RS23555 ENOG4108S0S Nucleotidyl transferase FNV66_RS23570 ENOG4108KGH TRANSCRIPTIONal FNV66_RS23575 ENOG4108KGH TRANSCRIPTIONal FNV66_RS23595 ENOG4108KGH TRANSCRIPTIONal FNV66_RS23605 ENOG4105PAD Hydrolase FNV66_RS23615 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS23620 ENOG4105C6Y Udp-glucose 6-dehydrogenase FNV66_RS23660 ENOG41065SU Two-component system sensor kinase FNV66_RS23665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS23670 ENOG4105DUX Transporter FNV66_RS23705 ENOG4108Z4X TRANSCRIPTIONal FNV66_RS23735 ENOG41082AN stage II sporulation protein FNV66_RS23740 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV66_RS23750 ENOG4105CI2 imidazolone-5-propionate hydrolase FNV66_RS23765 ENOG4105CGP Urocanate hydratase FNV66_RS23805 ENOG4105C84 Histidine ammonia-lyase FNV66_RS23810 ENOG4108IJ8 ABC transporter FNV66_RS23815 ENOG4105E90 ABC transporter FNV66_RS23820 ENOG4105E90 ABC transporter FNV66_RS23830 ENOG41060NJ transcriptional regulator FNV66_RS23845 ENOG4108V9Q carbonic anhydrase FNV66_RS23865 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS23905 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV66_RS23910 ENOG4107RBB ABC transporter, permease FNV66_RS23915 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FNV66_RS23920 ENOG4105CEP NADH dehydrogenase FNV66_RS23940 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FNV66_RS23955 ENOG4106A3M Cytochrome p-450 FNV66_RS24020 ENOG4105XYF acetyltransferase FNV66_RS24090 ENOG4105EJ2 Transcriptional regulator FNV66_RS24105 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV66_RS24110 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV66_RS24115 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV66_RS24125 ENOG4107QN1 sodium solute FNV66_RS24155 ENOG4108ZGX Histidine kinase FNV66_RS24170 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FNV66_RS24175 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FNV66_RS24180 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FNV66_RS24185 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FNV66_RS24195 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FNV66_RS24205 ENOG41067SE Tetr family transcriptional regulator FNV66_RS24215 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FNV66_RS24220 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FNV66_RS24225 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS24235 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FNV66_RS24280 ENOG4105C5H ABC transporter FNV66_RS24290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FNV66_RS24295 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FNV66_RS24305 ENOG4105F8V Hydrolase, tatD family FNV66_RS24350 ENOG4108ZFD Antibiotic biosynthesis monooxygenase FNV66_RS24355 ENOG4107Y2X deaminase FNV66_RS24360 ENOG4107RVG penicillin-binding protein FNV66_RS24385 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FNV66_RS24395 ENOG4108JJB ABC transporter FNV66_RS24400 ENOG4105K56 Transcriptional regulator FNV66_RS24405 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV66_RS24425 ENOG4105CPC Aldo Keto reductase FNV66_RS24430 ENOG4108RF4 Tetr family transcriptional regulator FNV66_RS24435 ENOG4105EYF MMPL domain protein FNV66_RS24455 ENOG4108R85 Short chain dehydrogenase FNV66_RS24460 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV66_RS24465 ENOG4105F95 Monooxygenase FNV66_RS24475 ENOG4105CGK Exodeoxyribonuclease III FNV66_RS24495 ENOG4108Z9I -acetyltransferase FNV66_RS24500 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FNV66_RS24505 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FNV66_RS24515 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FNV66_RS24520 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase FNV66_RS24530 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FNV66_RS24545 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) FNV66_RS24555 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FNV66_RS24575 ENOG4105FF0 ErfK YbiS YcfS YnhG FNV66_RS24590 ENOG4105DM4 PTS System FNV66_RS24595 ENOG4105DE4 1-phosphofructokinase FNV66_RS24600 ENOG4105E98 transcriptional regulator DeoR family FNV66_RS24630 ENOG4108Z7F N-acetyltransferase FNV66_RS24635 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FNV66_RS24665 ENOG4107HP6 Transcriptional regulator FNV66_RS24805 ENOG4107QN1 sodium solute FNV66_RS24825 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS24830 ENOG4105BZU Histidine kinase FNV66_RS24890 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS24920 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS24925 ENOG4108ZGX Histidine kinase FNV66_RS24950 ENOG4105DNP FAD linked oxidase domain protein FNV66_RS24995 ENOG4108V06 Glutathione peroxidase FNV66_RS25010 ENOG4105DZ1 carboxypeptidase FNV66_RS25065 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FNV66_RS25085 ENOG4105KVH Transcriptional regulator FNV66_RS25095 ENOG4105EMU Dehydrogenase FNV66_RS25100 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FNV66_RS25105 ENOG41088PD hydrolase FNV66_RS25190 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS25210 ENOG4108762 serine threonine protein kinase FNV66_RS25230 ENOG4105D2B acyl-CoA dehydrogenase FNV66_RS25240 ENOG4108I0C methyltransferase FNV66_RS25245 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FNV66_RS25250 ENOG4107RSM transcriptional regulator FNV66_RS25295 ENOG4105CGU Enoyl-CoA hydratase FNV66_RS25300 ENOG4105MXW flavin reductase domain protein, FMN-binding FNV66_RS25305 ENOG4105D2S major facilitator superfamily FNV66_RS25320 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS25340 ENOG4105D2B acyl-CoA dehydrogenase FNV66_RS25345 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS25355 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS25360 ENOG4107EG8 signal transduction protein with EFhand domain FNV66_RS25365 ENOG41082AN stage II sporulation protein FNV66_RS25370 ENOG4105K6V RNA polymerase FNV66_RS25420 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV66_RS25430 ENOG4108SU4 UPF0309 protein FNV66_RS25450 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FNV66_RS25460 ENOG4105CGU Enoyl-CoA hydratase FNV66_RS25465 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS25480 ENOG4107QX3 carboxylase FNV66_RS25515 ENOG4105BZ1 (ABC) transporter FNV66_RS25520 ENOG4105CQB FAD linked oxidase domain protein FNV66_RS25545 ENOG4106A3M Cytochrome p-450 FNV66_RS25555 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FNV66_RS25575 ENOG4108Z6Z Transcriptional regulator FNV66_RS25585 ENOG4105CPC Aldo Keto reductase FNV66_RS25600 ENOG4105XMC MarR family Transcriptional regulator FNV66_RS25610 ENOG4105C7N Xanthine uracil vitamin C permease FNV66_RS25620 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FNV66_RS25645 ENOG4108N0W Major Facilitator superfamily FNV66_RS25655 ENOG4108UIH futalosine nucleosidase FNV66_RS25660 ENOG4105E63 Pfam:DUF178 FNV66_RS25665 ENOG4105VEQ Cold shock protein FNV66_RS25690 ENOG4105CFI type iii restriction protein res subunit FNV66_RS25705 ENOG4105EEM helicase FNV66_RS25710 ENOG4106N3A copper homeostasis protein cutc FNV66_RS25730 ENOG4105KNA -acetyltransferase FNV66_RS25745 ENOG4105QEK Transcriptional regulator FNV66_RS25750 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FNV66_RS25755 ENOG4105C5Y PTS System FNV66_RS25790 ENOG4108Z6Z Transcriptional regulator FNV66_RS25795 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV66_RS25800 ENOG4105EBR Carboxylesterase FNV66_RS25810 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FNV66_RS25830 ENOG4105C3Q Glycosyl transferase, family 2 FNV66_RS25855 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) FNV66_RS25860 ENOG4105CE4 GlcNAc 6-P deacetylase FNV66_RS25880 ENOG4105BZU Histidine kinase FNV66_RS25885 ENOG4105MXW flavin reductase domain protein, FMN-binding FNV66_RS25900 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FNV66_RS25925 ENOG4105CD8 aminopeptidase N FNV66_RS26035 ENOG4105C2N RNA methyltransferase TrmH family group 3 FNV66_RS26040 ENOG4105C8N cysteinyl-tRNA synthetase FNV66_RS26045 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FNV66_RS26050 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FNV66_RS26055 ENOG4108VJ1 Transcriptional regulator (CarD family FNV66_RS26070 ENOG4105BZU Histidine kinase FNV66_RS26105 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV66_RS26125 ENOG4105QNJ serralysin (EC 3.4.24.40) FNV66_RS26130 ENOG4108YZJ Pfam:DUF2596 FNV66_RS26135 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FNV66_RS26175 ENOG4105ECP epimerase FNV66_RS26180 ENOG4108KPJ rna polymerase sigma factor FNV66_RS26190 ENOG4105CHR reductase FNV66_RS26200 ENOG4108XFH Transcriptional regulator FNV66_RS26205 ENOG4105CPQ Dehydrogenase FNV66_RS26250 ENOG4105HHS UPF0256 protein FNV66_RS26265 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FNV66_RS26270 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FNV66_RS26275 ENOG41090R7 Ferric uptake FNV66_RS26280 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands FNV66_RS26310 ENOG4105PKJ carbohydrate binding FNV66_RS26315 ENOG4105KHC sulfurtransferase FNV66_RS26340 ENOG4107NHD transcriptional regulator FNV66_RS26345 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS26350 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FNV66_RS26355 ENOG4105C0H protease FNV66_RS26375 ENOG4105ETX regulatoR FNV66_RS26380 ENOG4105BZ1 (ABC) transporter FNV66_RS26395 ENOG4105CGH 5'-nucleotidase FNV66_RS26400 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FNV66_RS26415 ENOG4105CJ1 ABC, transporter FNV66_RS26430 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FNV66_RS26435 ENOG4105CZV ABC transporter FNV66_RS26450 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FNV66_RS26480 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS26485 ENOG4105CJ3 phosphate transporter FNV66_RS26495 ENOG4105VPX protein, conserved in bacteria FNV66_RS26515 ENOG4105DNP FAD linked oxidase domain protein FNV66_RS26520 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FNV66_RS26525 ENOG4105E4C Lytic transglycosylase catalytic FNV66_RS26640 ENOG4105ESP cell wall surface anchor family protein FNV66_RS26660 ENOG4105D5U fad dependent oxidoreductase FNV66_RS26665 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FNV66_RS26675 ENOG4105CPC Aldo Keto reductase FNV66_RS26710 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FNV66_RS26730 ENOG4105C1J atp-dependent rna helicase FNV66_RS26770 ENOG4105CQ7 ATP-dependent helicase FNV66_RS26790 ENOG4108TAC FNV66_RS26805 ENOG4105CXB phosphoribosylaminoimidazole synthetase FNV66_RS26825 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FNV66_RS26830 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FNV66_RS26835 ENOG410839H phosphoribosylformylglycinamidine synthase FNV66_RS26865 ENOG4105BZU Histidine kinase FNV66_RS26880 ENOG4105C8V SAICAR synthetase FNV66_RS26895 ENOG4105C12 Phosphoribosylglycinamide synthetase FNV66_RS26935 ENOG4105I6B RNA polymerase FNV66_RS26980 ENOG4105D7A ATP-binding protein FNV66_RS26995 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FNV66_RS27010 ENOG4108Z6B deaminase FNV66_RS27025 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein FNV66_RS27030 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV66_RS27035 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV66_RS27050 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FNV66_RS27065 ENOG410905P Pyridoxamine 5-phosphate FNV66_RS27075 ENOG4105C57 major facilitator superfamily FNV66_RS27080 ENOG4105EDW glycosyl transferase, family 39 FNV66_RS27090 ENOG4105BZU Histidine kinase FNV66_RS27095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS27105 ENOG4105KAC Antibiotic biosynthesis monooxygenase FNV66_RS27165 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS27170 ENOG4105NAF rna polymerase sigma factor FNV66_RS27185 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS27195 ENOG4105X7H acyl-CoA dehydrogenase FNV66_RS27255 ENOG4105C0H protease FNV66_RS27270 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FNV66_RS27290 ENOG4107T6F Xaa-Pro aminopeptidase FNV66_RS27305 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FNV66_RS27325 ENOG4105EYF MMPL domain protein FNV66_RS27330 ENOG4105BZU Histidine kinase FNV66_RS27365 ENOG4105DBE peroxidase FNV66_RS27370 ENOG4105CQC Prephenate dehydratase FNV66_RS27375 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FNV66_RS27380 ENOG410667J hydrolase FNV66_RS27410 ENOG4105DA5 (ABC) transporter FNV66_RS27420 ENOG4107SWG transcriptional regulator MERR family FNV66_RS27425 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) FNV66_RS27435 ENOG410667J hydrolase FNV66_RS27445 ENOG4108JJ9 ABC, transporter FNV66_RS27450 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FNV66_RS27455 ENOG4105C4M (Ubiquinol oxidase) subunit I FNV66_RS27460 ENOG4105CIH Imidazole acetol-phosphate transaminase FNV66_RS27465 ENOG4107P2S Transcriptional regulator FNV66_RS27470 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FNV66_RS27485 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FNV66_RS27510 ENOG4106048 Cupin 2, conserved barrel domain protein FNV66_RS27515 ENOG41082T9 Membrane FNV66_RS27520 ENOG4105KJF protein tyrosine phosphatase FNV66_RS27525 ENOG4105C28 cystathionine FNV66_RS27560 ENOG4105F27 Major Facilitator FNV66_RS27580 ENOG4105CDU Replicative dna helicase FNV66_RS27590 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FNV66_RS27595 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FNV66_RS27600 ENOG4107YH6 single-stranded DNA-binding protein FNV66_RS27605 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) FNV66_RS27630 ENOG4108JQC penicillin-binding protein 1A FNV66_RS27655 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FNV66_RS27685 ENOG4105C3M thioredoxin reductase FNV66_RS27690 ENOG4105K63 Thioredoxin FNV66_RS27705 ENOG4107QJE Chromosome Partitioning Protein FNV66_RS27710 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FNV66_RS27720 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FNV66_RS27725 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FNV66_RS27730 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FNV66_RS27740 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FNV66_RS27745 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FNV66_RS27750 ENOG4108J5G 6-phosphogluconate dehydrogenase FNV66_RS27755 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FNV66_RS27760 ENOG4105K7N UPF0232 protein FNV66_RS27765 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FNV66_RS27770 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FNV66_RS27805 ENOG4108UGD Serine Threonine protein kinase FNV66_RS27835 ENOG4105ZJT Cell division protein CrgA FNV66_RS27845 ENOG4108U4N (sortase) family FNV66_RS27860 ENOG4108U4N (sortase) family FNV66_RS27865 ENOG4108RN7 integral membrane protein FNV66_RS27875 ENOG4105CJN penicillin-binding protein FNV66_RS27890 ENOG4105HZM Fha domain containing protein FNV66_RS27895 ENOG4105TV9 FHA Domain-Containing protein FNV66_RS27920 ENOG41064MX Tetr family transcriptional regulator FNV66_RS27925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS27940 ENOG4108JIK carboxylase FNV66_RS27955 ENOG4105CZS beta-ketoacyl synthase FNV66_RS28000 ENOG4105D8K carboxyl transferase FNV66_RS28040 ENOG4105KVH Transcriptional regulator FNV66_RS28045 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV66_RS28065 ENOG4105DNP FAD linked oxidase domain protein FNV66_RS28085 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FNV66_RS28125 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FNV66_RS28135 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV66_RS28140 ENOG4108IG5 Transcriptional regulator FNV66_RS28160 ENOG4107QSN dihydrolipoamide acetyltransferase FNV66_RS28165 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FNV66_RS28195 ENOG4107QPV Serine Threonine protein kinase FNV66_RS28225 ENOG4105CPP Dehydrogenase, E1 component FNV66_RS28230 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 FNV66_RS28285 ENOG4105DFM M18 family aminopeptidase FNV66_RS28290 ENOG4105CSU acyl-Coa dehydrogenase FNV66_RS28300 ENOG4105EUB pirin domain protein FNV66_RS28315 ENOG4105C9M aspartyl-trna synthetase FNV66_RS28345 ENOG4108J20 pectate lyase FNV66_RS28355 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FNV66_RS28370 ENOG4105EM2 membrane FNV66_RS28380 ENOG4105F2Z 3-oxoadipate enol-lactonase FNV66_RS28385 ENOG4107SQD Transcriptional regulator, GntR family FNV66_RS28415 ENOG4105BZU Histidine kinase FNV66_RS28420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS28435 ENOG4107T3P ABC, transporter FNV66_RS28440 ENOG4105CH2 amidohydrolase FNV66_RS28460 ENOG4105EUZ Beta-lactamase domain protein FNV66_RS28470 ENOG4105BZ4 penicillin-binding protein FNV66_RS28505 ENOG4105VEQ Cold shock protein FNV66_RS28540 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FNV66_RS28590 ENOG4105D9P serine threonine protein kinase FNV66_RS28605 ENOG4105JVQ RNA Polymerase FNV66_RS28615 ENOG4108HCJ Hydrolase FNV66_RS28660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS28665 ENOG4105BZU Histidine kinase FNV66_RS28675 ENOG4105EYF MMPL domain protein FNV66_RS28680 ENOG4105BZU Histidine kinase FNV66_RS28685 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS28705 ENOG41082SX arsR family transcriptional regulator FNV66_RS28710 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FNV66_RS28790 ENOG4105CSR polyphosphate kinase 2 FNV66_RS28795 ENOG4105BZP glycoside hydrolase 15-related FNV66_RS28800 ENOG4105C57 major facilitator superfamily FNV66_RS28830 ENOG4105E2A Dehydrogenase FNV66_RS28875 ENOG4108JQC penicillin-binding protein 1A FNV66_RS28890 ENOG4108762 serine threonine protein kinase FNV66_RS28940 ENOG4106F60 Histidine kinase FNV66_RS28945 ENOG4105ETX regulatoR FNV66_RS29010 ENOG4105DHP deoxycytidine triphosphate deaminase FNV66_RS29035 ENOG4105DF6 Fe-S oxidoreductase FNV66_RS29045 ENOG4105CFG Acts as a chaperone (By similarity) FNV66_RS29050 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FNV66_RS29055 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FNV66_RS29060 ENOG4105KNI merR family transcriptional Regulator FNV66_RS29065 ENOG4105DFW ABC transporter FNV66_RS29125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FNV66_RS29150 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FNV66_RS29165 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FNV66_RS29170 ENOG4107RCW fructose-bisphosphate aldolase FNV66_RS29190 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FNV66_RS29215 ENOG4108ZGX Histidine kinase FNV66_RS29220 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS29230 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS29245 ENOG4105DIM ABC transporter FNV66_RS29250 ENOG4105CIG ABC transporter FNV66_RS29265 ENOG4105CPD ethanolamine ammonia-lyase FNV66_RS29270 ENOG4107FQ9 ethanolamine ammonia-lyase FNV66_RS29280 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FNV66_RS29285 ENOG4105CGH 5'-nucleotidase FNV66_RS29295 ENOG4108WYP Transcriptional regulator FNV66_RS29300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FNV66_RS29305 ENOG4108V4B ThiJ pfpI FNV66_RS29325 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FNV66_RS29330 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FNV66_RS29365 ENOG4105BZU Histidine kinase FNV66_RS29375 ENOG4105CFH Aspartokinase FNV66_RS29415 ENOG4105D17 glycoside hydrolase, family 3 domain protein FNV66_RS29440 ENOG4107TPY serine threonine protein kinase FNV66_RS29480 ENOG4108IUX (ABC) transporter FNV66_RS29540 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FNV66_RS29590 ENOG4105BZ4 penicillin-binding protein FNV66_RS29625 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FNV66_RS29640 ENOG4105P8F nudix hydrolase FNV66_RS29650 ENOG4105D74 hydrolase FNV66_RS29660 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FNV66_RS29665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FNV66_RS29670 ENOG4105CHH sulfate transporter FNV66_RS29730 ENOG4108I5C dEAD DEAH box helicase FNV66_RS29735 ENOG4105WN5 stage II sporulation protein FNV66_RS29740 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FNV66_RS29745 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for FNV66_RS29760 ENOG4108DT4 serine threonine protein kinase FNV66_RS29770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FNV66_RS29775 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FNV66_RS29780 ENOG4105C6E dna polymerase iii FNV66_RS29825 ENOG4105CRK lysyL-tRNA synthetase FNV66_RS29830 ENOG4105F0K SARP family transcriptional regulator FNV66_RS29870 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS29945 ENOG4105C2M dna polymerase I FNV66_RS29970 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FNV66_RS29975 ENOG4105KDC 50s ribosomal protein l28 FNV66_RS29980 ENOG4105W0E 50S ribosomal protein L33 FNV66_RS29985 ENOG4105NRA 50s ribosomal protein l31 type b FNV66_RS29995 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FNV66_RS30015 ENOG4105C26 Dehydrogenase FNV66_RS30035 ENOG4105CVK Glutamate decarboxylase FNV66_RS30045 ENOG4107TXC Transcriptional regulator FNV66_RS30050 ENOG41082VC UPF0145 protein FNV66_RS30065 ENOG4105F0N pyrophosphate phospho-hydrolase FNV66_RS30080 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FNV66_RS30085 ENOG4108UGV hypoxanthine phosphoribosyltransferase FNV66_RS30095 ENOG4105EUJ GTP cyclohydrolase i FNV66_RS30105 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FNV66_RS30125 ENOG4105CRK lysyL-tRNA synthetase FNV66_RS30150 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS30165 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS30170 ENOG4105I1F Resistance protein FNV66_RS30195 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FNV66_RS30200 ENOG4108IYU L-aspartate oxidase FNV66_RS30210 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FNV66_RS30255 ENOG4105DR5 peptidase FNV66_RS30260 ENOG4108IG5 Transcriptional regulator FNV66_RS30270 ENOG4108FKE two-component system sensor kinase FNV66_RS30275 ENOG4108PYU two-component system response regulator FNV66_RS30280 ENOG41075QH Lipoprotein CseA FNV66_RS30285 ENOG4105NAF rna polymerase sigma factor FNV66_RS30300 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FNV66_RS30315 ENOG4108JWX FNV66_RS30320 ENOG4107R33 ppx gppa phosphatase FNV66_RS30325 ENOG4105EY0 Xylose isomerase domain protein TIM barrel FNV66_RS30330 ENOG4105XEA Tetr family transcriptional regulator FNV66_RS30335 ENOG4105C01 Dihydroxy-acid dehydratase FNV66_RS30340 ENOG4108762 serine threonine protein kinase FNV66_RS30350 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein FNV66_RS30360 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS30370 ENOG4105CJ1 ABC, transporter FNV66_RS30380 ENOG4105II7 pyrroline-5-carboxylate reductase FNV66_RS30385 ENOG4105C31 Tryptophanyl-tRNA synthetase FNV66_RS30420 ENOG4105DGU Histone deacetylase FNV66_RS30425 ENOG4108XFF FNV66_RS30470 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FNV66_RS30475 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FNV66_RS30480 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FNV66_RS30485 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FNV66_RS30490 ENOG4105D52 delta-aminolevulinic acid dehydratase FNV66_RS30520 ENOG4105C75 arginyL-tRNA synthetase FNV66_RS30525 ENOG4105DK7 lysyl-tRNA synthetase FNV66_RS30545 ENOG4105E0Y RtcB Protein FNV66_RS30565 ENOG4105KK4 UPF0060 membrane protein FNV66_RS30580 ENOG4105KVH Transcriptional regulator FNV66_RS30605 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FNV66_RS30610 ENOG4108UZX fmn reductase FNV66_RS30635 ENOG4105C0X amino acid FNV66_RS30645 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV66_RS30655 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS30665 ENOG4105D0M Protease HtpX homolog FNV66_RS30675 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FNV66_RS30685 ENOG4108ZJ4 polysaccharide deacetylase FNV66_RS30700 ENOG4105C0X amino acid FNV66_RS30720 ENOG4105D7N magnesium and cobalt transport protein CorA FNV66_RS30725 ENOG4107XWI flavin reductase domain protein, FMN-binding FNV66_RS30735 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FNV66_RS30740 ENOG4108RH7 phosphoglycerate mutase FNV66_RS30760 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) FNV66_RS30765 ENOG4105CRE cytochrome C FNV66_RS30810 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS30820 ENOG4105YVS arsR family transcriptional regulator FNV66_RS30840 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FNV66_RS30845 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FNV66_RS30850 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FNV66_RS30860 ENOG4105DVY radical SAM domain protein FNV66_RS30875 ENOG4108R86 Transcriptional regulator FNV66_RS30885 ENOG4105CHR reductase FNV66_RS30890 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS30900 ENOG4105VEQ Cold shock protein FNV66_RS30905 ENOG4105EV6 Pfam:DUF178 FNV66_RS30920 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FNV66_RS30950 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS30960 ENOG4105KNA -acetyltransferase FNV66_RS30970 ENOG41068JE domain protein FNV66_RS30980 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS30985 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FNV66_RS30990 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS31000 ENOG4107QIZ NADH dehydrogenase FNV66_RS31005 ENOG4108IEH NADH dehydrogenase subunit g FNV66_RS31010 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FNV66_RS31015 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS31020 ENOG4105DF2 NADH dehydrogenase subunit j FNV66_RS31025 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS31030 ENOG4105D65 subunit l FNV66_RS31040 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS31045 ENOG4105C9U ATP-dependent DNA helicase RecQ FNV66_RS31070 ENOG4105CAY ferredoxin--nadp reductase FNV66_RS31080 ENOG4108FKH Transglycosylase SLT domain FNV66_RS31110 ENOG4105CJ1 ABC, transporter FNV66_RS31120 ENOG4108WS4 fmn reductase FNV66_RS31145 ENOG4105ECR NmrA family FNV66_RS31150 ENOG4105KVH Transcriptional regulator FNV66_RS31155 ENOG4105DQU oxidoreductase, subunit beta FNV66_RS31160 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FNV66_RS31180 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FNV66_RS31185 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS31190 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FNV66_RS31195 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FNV66_RS31200 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS31205 ENOG4107YX3 NADH dehydrogenase subunit j FNV66_RS31210 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS31220 ENOG4105C8S subunit m FNV66_RS31225 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FNV66_RS31230 ENOG4105D0M Protease HtpX homolog FNV66_RS31235 ENOG410901E Membrane FNV66_RS31255 ENOG4105Y3U Transglycosylase-associated protein FNV66_RS31260 ENOG4108VPT UPF0234 protein FNV66_RS31360 ENOG4105FDP GntR family transcriptional regulator FNV66_RS31365 ENOG4108UGD Serine Threonine protein kinase FNV66_RS31390 ENOG4105DZC cytosine deaminase FNV66_RS31405 ENOG4105WDJ 50S ribosomal protein L33 FNV66_RS31410 ENOG410900P UPF0336 protein FNV66_RS31430 ENOG4107R4N Cell wall formation (By similarity) FNV66_RS31435 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FNV66_RS31450 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FNV66_RS31470 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FNV66_RS31475 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FNV66_RS31480 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FNV66_RS31490 ENOG4105QCJ Lipoprotein FNV66_RS31495 ENOG4108VZM 50s ribosomal protein L10 FNV66_RS31500 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FNV66_RS31505 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV66_RS31510 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV66_RS31540 ENOG4107V6Q Cyclic nucleotide-binding domain FNV66_RS31545 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FNV66_RS31550 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FNV66_RS31555 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FNV66_RS31560 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FNV66_RS31575 ENOG4106A3M Cytochrome p-450 FNV66_RS31620 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FNV66_RS31625 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FNV66_RS31630 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FNV66_RS31635 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FNV66_RS31640 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FNV66_RS31645 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FNV66_RS31650 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FNV66_RS31655 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FNV66_RS31660 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FNV66_RS31665 ENOG41082SA 50s ribosomal protein l29 FNV66_RS31670 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FNV66_RS31675 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FNV66_RS31680 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FNV66_RS31685 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FNV66_RS31690 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FNV66_RS31695 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FNV66_RS31700 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FNV66_RS31705 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FNV66_RS31710 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FNV66_RS31715 ENOG410849U 50S ribosomal protein L30 FNV66_RS31720 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FNV66_RS31730 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FNV66_RS31740 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FNV66_RS31745 ENOG41067V7 50S ribosomal protein L36 FNV66_RS31750 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FNV66_RS31755 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FNV66_RS31760 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV66_RS31765 ENOG4108ZT0 50S ribosomal protein l17 FNV66_RS31770 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FNV66_RS31780 ENOG4107QZ7 Cellulose synthase catalytic subunit FNV66_RS31800 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FNV66_RS31810 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FNV66_RS31815 ENOG4108UJD 30S ribosomal protein S9 FNV66_RS31820 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FNV66_RS31825 ENOG4105CS9 pantothenic acid kinase FNV66_RS31830 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FNV66_RS31890 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FNV66_RS31895 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FNV66_RS31900 ENOG4108097 ATP-binding protein FNV66_RS31920 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FNV66_RS31930 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS31955 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS31980 ENOG4105CHP RNA polymerase FNV66_RS32000 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FNV66_RS32005 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FNV66_RS32015 ENOG4105EMU Dehydrogenase FNV66_RS32025 ENOG4105DND Transcriptional regulator FNV66_RS32030 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV66_RS32040 ENOG4108MMM RNA Polymerase FNV66_RS32050 ENOG4107QVP Dehydrogenase FNV66_RS32060 ENOG4107QQG Dehydrogenase FNV66_RS32065 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FNV66_RS32085 ENOG4107TPY serine threonine protein kinase FNV66_RS32090 ENOG4105D9P serine threonine protein kinase FNV66_RS32095 ENOG4107TPY serine threonine protein kinase FNV66_RS32100 ENOG4105C26 Dehydrogenase FNV66_RS32125 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FNV66_RS32170 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS32205 ENOG4105DR5 peptidase FNV66_RS32230 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FNV66_RS32235 ENOG4105RD5 FNV66_RS32240 ENOG4105DEG Vwa containing coxe family protein FNV66_RS32250 ENOG4105CMV Succinyl-CoA synthetase subunit beta FNV66_RS32280 ENOG4105DC1 bifunctional purine biosynthesis protein purh FNV66_RS32300 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FNV66_RS32320 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FNV66_RS32340 ENOG410645S MarR family Transcriptional regulator FNV66_RS32355 ENOG4108IJ7 Glycine betaine FNV66_RS32360 ENOG4108HQS Glycine betaine FNV66_RS32375 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV66_RS32380 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV66_RS32390 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV66_RS32400 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FNV66_RS32410 ENOG4108ES0 acetoacetyl-CoA synthetase FNV66_RS32420 ENOG4108ZFD Antibiotic biosynthesis monooxygenase FNV66_RS32440 ENOG4106032 Glutathionylspermidine synthase FNV66_RS32445 ENOG4105C8Y Acetylornithine aminotransferase FNV66_RS32450 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FNV66_RS32460 ENOG4105C31 Tryptophanyl-tRNA synthetase FNV66_RS32495 ENOG4107H3J ribonuclease FNV66_RS32505 ENOG4107RN3 metallophosphoesterase FNV66_RS32525 ENOG4105BZU Histidine kinase FNV66_RS32530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS32535 ENOG4105EYF MMPL domain protein FNV66_RS32575 ENOG4108J01 L-aspartate oxidase FNV66_RS32595 ENOG4105E2D ec 3.2.1.52 FNV66_RS32625 ENOG4108MMM RNA Polymerase FNV66_RS32630 ENOG4108MMM RNA Polymerase FNV66_RS32655 ENOG4108NIW Leucine export protein LeuE FNV66_RS32670 ENOG4105K64 Glycosyl transferase, family 2 FNV66_RS32680 ENOG4105F0R Cytidylyltransferase FNV66_RS32685 ENOG4105D2T synthase FNV66_RS32700 ENOG4105C8U phosphate abc transporter FNV66_RS32730 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS32735 ENOG4105K7W phage-related replication protein FNV66_RS32790 ENOG4107RM1 amidohydrolase FNV66_RS32795 ENOG4105DIH basic membrane FNV66_RS32800 ENOG4105DIH basic membrane FNV66_RS32805 ENOG4108JQ9 ABC transporter FNV66_RS32840 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FNV66_RS32845 ENOG4105D94 Major Facilitator Superfamily FNV66_RS32850 ENOG4107RSM transcriptional regulator FNV66_RS32860 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FNV66_RS32885 ENOG41065SU Two-component system sensor kinase FNV66_RS32890 ENOG4108KXV response regulator FNV66_RS32895 ENOG4105NAF rna polymerase sigma factor FNV66_RS32910 ENOG4105C26 Dehydrogenase FNV66_RS32915 ENOG4105C26 Dehydrogenase FNV66_RS32975 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS32990 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain FNV66_RS33020 ENOG4108JIK carboxylase FNV66_RS33030 ENOG4107WR6 Maf-like protein FNV66_RS33045 ENOG4105D8K carboxyl transferase FNV66_RS33055 ENOG4108QER Adenylate cyclase FNV66_RS33065 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS33070 ENOG4105KDM Diguanylate cyclase with gaf sensor FNV66_RS33075 ENOG4105C84 Histidine ammonia-lyase FNV66_RS33080 ENOG4105VEQ Cold shock protein FNV66_RS33085 ENOG4105C1J atp-dependent rna helicase FNV66_RS33115 ENOG4105C19 ABC transporter FNV66_RS33135 ENOG4105DQ4 alcohol dehydrogenase FNV66_RS33140 ENOG4105TVJ transport system, permease FNV66_RS33145 ENOG4105DQ5 transport system permease protein FNV66_RS33155 ENOG4107R16 Multicopper oxidase FNV66_RS33220 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FNV66_RS33245 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FNV66_RS33250 ENOG4105C7B Threonine dehydratase FNV66_RS33290 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FNV66_RS33300 ENOG4105T1M mycothiol conjugate amidase mca FNV66_RS33325 ENOG4105C7Z Conserved Protein FNV66_RS33360 ENOG4105C57 major facilitator superfamily FNV66_RS33370 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FNV66_RS33405 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FNV66_RS33465 ENOG4105CHM Aminotransferase FNV66_RS33495 ENOG4108FUF Transcriptional regulator, IclR family FNV66_RS33500 ENOG4105KME endoribonuclease L-psp FNV66_RS33505 ENOG4105C6Z Gluconate FNV66_RS33570 ENOG4107QMS site-determining protein FNV66_RS33600 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS33620 ENOG4107QKZ Ompa motb domain protein FNV66_RS33625 ENOG4105NAE bifunctional deaminase-reductase domain protein FNV66_RS33655 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FNV66_RS33660 ENOG4108IAB Phoh family FNV66_RS33675 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV66_RS33680 ENOG4105D3R alkyl hydroperoxide reductase FNV66_RS33695 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV66_RS33715 ENOG4105BZ4 penicillin-binding protein FNV66_RS33730 ENOG4105CH6 catalase FNV66_RS33745 ENOG4105C9Q fumarate hydratase class II FNV66_RS33765 ENOG4107GFK fumarate FNV66_RS33775 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV66_RS33790 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FNV66_RS33795 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FNV66_RS33800 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FNV66_RS33810 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FNV66_RS33825 ENOG4105C3G gtp-binding protein FNV66_RS33840 ENOG4107T94 Endo-14-beta-xylanase FNV66_RS33920 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FNV66_RS33940 ENOG4105CI3 gtp-binding protein typa FNV66_RS33955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV66_RS33965 ENOG4108JQ7 (ABC) transporter FNV66_RS33970 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase FNV66_RS33980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FNV66_RS33985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV66_RS33990 ENOG4105C3U ABC transporter FNV66_RS33995 ENOG4108JQ7 (ABC) transporter FNV66_RS34010 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FNV66_RS34030 ENOG4108M15 ABC transporter FNV66_RS34040 ENOG4105BZU Histidine kinase FNV66_RS34045 ENOG4108S01 response regulator FNV66_RS34060 ENOG4108Z4U Ferredoxin FNV66_RS34080 ENOG4107R4C succinyl-diaminopimelate desuccinylase FNV66_RS34085 ENOG4108URH decarboxylase FNV66_RS34090 ENOG4105EEI dihydropteroate synthase FNV66_RS34100 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FNV66_RS34105 ENOG4105CGU Enoyl-CoA hydratase FNV66_RS34125 ENOG4105DU6 RNA polymerase FNV66_RS34140 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FNV66_RS34165 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FNV66_RS34175 ENOG4105D7N magnesium and cobalt transport protein CorA FNV66_RS34185 ENOG4105DXB Major Facilitator superfamily FNV66_RS34200 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FNV66_RS34215 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FNV66_RS34260 ENOG4105DEF Extracellular solute-binding protein, family 5 FNV66_RS34265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV66_RS34330 ENOG4105C4R Atp-dependent dna helicase FNV66_RS34335 ENOG4107QSE Dipeptidase FNV66_RS34360 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV66_RS34430 ENOG41063PX domain protein FNV66_RS34440 ENOG4105DJZ UPF0182 protein FNV66_RS34470 ENOG4105C2X Arabinose 5-phosphate isomerase FNV66_RS34475 ENOG4107TK4 histidinol-phosphate phosphatase FNV66_RS34495 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FNV66_RS34505 ENOG4108RAV Conserved protein FNV66_RS34515 ENOG4105EMN RNA polymerase sigma factor FNV66_RS34520 ENOG4105WMN AntiSigma factor FNV66_RS34525 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FNV66_RS34540 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FNV66_RS34550 ENOG41068W2 Cytochrome p-450 FNV66_RS34570 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FNV66_RS34575 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FNV66_RS34595 ENOG4105FDP GntR family transcriptional regulator FNV66_RS34615 ENOG4105D17 glycoside hydrolase, family 3 domain protein FNV66_RS34620 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FNV66_RS34625 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FNV66_RS34640 ENOG4105CBD Diacylglycerol kinase FNV66_RS34685 ENOG4105ESN nucleotide-binding protein FNV66_RS34745 ENOG4108VEQ Superoxide dismutase FNV66_RS34765 ENOG4105CDA abc transporter atp-binding protein FNV66_RS34780 ENOG4105C6K Malic enzyme FNV66_RS34785 ENOG4105CB2 alcohol dehydrogenase FNV66_RS34820 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FNV66_RS34825 ENOG4105EB3 Histidine kinase FNV66_RS34830 ENOG4108PYU two-component system response regulator FNV66_RS34855 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FNV66_RS34915 ENOG4108IG5 Transcriptional regulator FNV66_RS34940 ENOG4108PJD permease FNV66_RS34945 ENOG4105CJN penicillin-binding protein FNV66_RS34950 ENOG4107QHZ cell cycle protein FNV66_RS34960 ENOG4108FKE two-component system sensor kinase FNV66_RS34985 ENOG4105FDF Could be involved in DNA repair (By similarity) FNV66_RS34990 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FNV66_RS35060 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FNV66_RS35125 ENOG4105CZE histidine utilization repressor FNV66_RS35190 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FNV66_RS35235 ENOG4105CNU cell division protein FtsK FNV66_RS35305 ENOG4105C75 arginyL-tRNA synthetase FNV66_RS35310 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FNV66_RS35315 ENOG4105D6E homoserine dehydrogenase FNV66_RS35320 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FNV66_RS35325 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FNV66_RS35335 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FNV66_RS35340 ENOG4108KGH TRANSCRIPTIONal FNV66_RS35345 ENOG4105VFB Binds the 23S rRNA (By similarity) FNV66_RS35350 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FNV66_RS35355 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FNV66_RS35365 ENOG4107ZF2 Phosphatase FNV66_RS35375 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FNV66_RS35380 ENOG4105ESV Glycosyl transferase, family 4 FNV66_RS35385 ENOG4105Z3P ATP synthase FNV66_RS35395 ENOG4105ZA1 atp synthase FNV66_RS35400 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FNV66_RS35405 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FNV66_RS35410 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FNV66_RS35415 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FNV66_RS35420 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FNV66_RS35425 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FNV66_RS35440 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS35450 ENOG4105IIP Membrane FNV66_RS35465 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV66_RS35480 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) FNV66_RS35525 ENOG4105CJ1 ABC, transporter FNV66_RS35545 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS35580 ENOG4105VCH membrane FNV66_RS35620 ENOG4105WX6 Membrane FNV66_RS35660 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FNV66_RS35665 ENOG4105C6K Malic enzyme FNV66_RS35670 ENOG4105CTQ phosphohexokinase FNV66_RS35715 ENOG4108MRH transcriptional regulatory protein FNV66_RS35720 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FNV66_RS35725 ENOG4105CK2 sodium dicarboxylate symporter FNV66_RS35735 ENOG4105C57 major facilitator superfamily FNV66_RS35770 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FNV66_RS35775 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) FNV66_RS35785 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FNV66_RS35790 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin FNV66_RS35795 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FNV66_RS35815 ENOG4105BZ1 (ABC) transporter FNV66_RS35820 ENOG4105BZ1 (ABC) transporter FNV66_RS35825 ENOG4105BZ1 (ABC) transporter FNV66_RS35830 ENOG4105BZ1 (ABC) transporter FNV66_RS35835 ENOG4105CJ1 ABC, transporter FNV66_RS35845 ENOG4105BZU Histidine kinase FNV66_RS35850 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS35860 ENOG4105S7A ErfK ybiS ycfS ynhG family protein FNV66_RS35865 ENOG41069FZ L,D-transpeptidase catalytic domain FNV66_RS35910 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) FNV66_RS35935 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS35990 ENOG4105CHR reductase FNV66_RS36015 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FNV66_RS36040 ENOG4105EWK phytoene FNV66_RS36050 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FNV66_RS36070 ENOG4105WQT MbtH domain protein FNV66_RS36075 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS36075 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS36085 ENOG4105DNP FAD linked oxidase domain protein FNV66_RS36100 ENOG4108JQ1 Dehydrogenase FNV66_RS36105 ENOG4105EJQ L-serine dehydratase FNV66_RS36110 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FNV66_RS36115 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FNV66_RS36120 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FNV66_RS36140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV66_RS36160 ENOG4108JQ7 (ABC) transporter FNV66_RS36175 ENOG4105EN6 Membrane FNV66_RS36195 ENOG4105D29 Helix-turn-helix type 11 domain protein FNV66_RS36205 ENOG4105EJ2 Transcriptional regulator FNV66_RS36235 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FNV66_RS36245 ENOG4108URH decarboxylase FNV66_RS36250 ENOG4105EMU Dehydrogenase FNV66_RS36260 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FNV66_RS36265 ENOG4105BZU Histidine kinase FNV66_RS36270 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FNV66_RS36275 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FNV66_RS36285 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FNV66_RS36290 ENOG4105EYF MMPL domain protein FNV66_RS36295 ENOG4105D9U N-acetyltransferase FNV66_RS36310 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS36325 ENOG4105CPC Aldo Keto reductase FNV66_RS36345 ENOG4108ZP8 Acetolactate synthase small subunit FNV66_RS36350 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FNV66_RS36360 ENOG4107SM8 Adenylate Guanylate cyclase FNV66_RS36365 ENOG4105C57 major facilitator superfamily FNV66_RS36385 ENOG4105T0Z Conserved Protein FNV66_RS36400 ENOG4105C26 Dehydrogenase FNV66_RS36415 ENOG4105CGS Alpha-glucosidase FNV66_RS36425 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV66_RS36435 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FNV66_RS36440 ENOG4105CM2 brancheD-chain amino acid aminotransferase FNV66_RS36465 ENOG4105CQM Urea amidohydrolase subunit alpha FNV66_RS36470 ENOG4105DWY Agmatine deiminase FNV66_RS36480 ENOG4105CSH Transporter FNV66_RS36485 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FNV66_RS36495 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV66_RS36510 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS36520 ENOG4105CJ1 ABC, transporter FNV66_RS36555 ENOG4105BZU Histidine kinase FNV66_RS36565 ENOG4108YYC ycei family FNV66_RS36570 ENOG4105D8K carboxyl transferase FNV66_RS36590 ENOG4105GWZ Roadblock lc7 family protein FNV66_RS36610 ENOG4105GWZ Roadblock lc7 family protein FNV66_RS36625 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FNV66_RS36630 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FNV66_RS36680 ENOG41069M3 Transcriptional regulator FNV66_RS36685 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FNV66_RS36690 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FNV66_RS36700 ENOG4105K70 DNA-binding protein FNV66_RS36720 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FNV66_RS36725 ENOG4105CPF Cell wall formation (By similarity) FNV66_RS36750 ENOG4105VB9 50S ribosomal protein l28 FNV66_RS36755 ENOG4105DP4 dak2 domain fusion protein ylov FNV66_RS36775 ENOG4106H78 methyltransferase FNV66_RS36780 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FNV66_RS36795 ENOG41084BZ 50S ribosomal protein L32 FNV66_RS36800 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FNV66_RS36805 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FNV66_RS36810 ENOG4105KVH Transcriptional regulator FNV66_RS36820 ENOG4105D9P serine threonine protein kinase FNV66_RS36835 ENOG4105K4I Scp-like extracellular FNV66_RS36840 ENOG4108375 Acylphosphatase (EC 3.6.1.7) FNV66_RS36895 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FNV66_RS36905 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FNV66_RS36915 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FNV66_RS36925 ENOG4105K5M 30s ribosomal protein S16 FNV66_RS36930 ENOG41082KU UPF0109 protein FNV66_RS36935 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FNV66_RS36940 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FNV66_RS36945 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FNV66_RS36955 ENOG4107QYR Signal peptidase i FNV66_RS36970 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FNV66_RS36980 ENOG41080R2 UPF0102 protein FNV66_RS36995 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV66_RS37010 ENOG4105CE9 30S ribosomal protein S2 FNV66_RS37015 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FNV66_RS37020 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FNV66_RS37025 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FNV66_RS37030 ENOG4105KNE Phosphatidate cytidylyltransferase FNV66_RS37040 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FNV66_RS37050 ENOG4108I5D sulfate abc transporter FNV66_RS37055 ENOG4108UCS ABC, transporter FNV66_RS37085 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV66_RS37090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FNV66_RS37100 ENOG4105C26 Dehydrogenase FNV66_RS37145 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS37165 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FNV66_RS37190 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS37195 ENOG4105F38 ABC transporter, permease FNV66_RS37200 ENOG4105D38 putrescine abc transporter FNV66_RS37205 ENOG4105CJP fad dependent oxidoreductase FNV66_RS37235 ENOG4105G9B Transcriptional regulator FNV66_RS37235 ENOG4105G9B Transcriptional regulator FNV66_RS37250 ENOG4105E0S extracellular solute-binding protein family 1 FNV66_RS37260 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FNV66_RS37295 ENOG4107P2S Transcriptional regulator FNV66_RS37315 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FNV66_RS37325 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FNV66_RS37330 ENOG4105DZP Membrane-associated zinc metalloprotease FNV66_RS37335 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FNV66_RS37350 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FNV66_RS37380 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase FNV66_RS37395 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) FNV66_RS37410 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FNV66_RS37420 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FNV66_RS37425 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FNV66_RS37445 ENOG4105C3U ABC transporter FNV66_RS37450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FNV66_RS37455 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FNV66_RS37485 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin FNV66_RS37560 ENOG4105EC2 ftsk spoIIIe FNV66_RS37575 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FNV66_RS37580 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FNV66_RS37585 ENOG4105C1V Peptidase, M16 FNV66_RS37590 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FNV66_RS37615 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV66_RS37620 ENOG4105CN5 Metallo-Beta-Lactamase FNV66_RS37655 ENOG4105BZU Histidine kinase FNV66_RS37660 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FNV66_RS37665 ENOG4107QZI cell division protein FtsK FNV66_RS37675 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FNV66_RS37685 ENOG4105CEV competence damage-inducible protein FNV66_RS37690 ENOG4105WBV Transcriptional regulator FNV66_RS37695 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FNV66_RS37700 ENOG4105CHR reductase FNV66_RS37705 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FNV66_RS37710 ENOG4107QRT dEAD DEAH box helicase FNV66_RS37740 ENOG4105DSF transport protein FNV66_RS37750 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FNV66_RS37770 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FNV66_RS37780 ENOG4107SCK Monooxygenase FNV66_RS37785 ENOG4105DRP amino acid AbC transporter FNV66_RS37790 ENOG4108Q1T ABC transporter FNV66_RS37795 ENOG4107UBR Extracellular solute-binding protein family 3 FNV66_RS37800 ENOG4105CDA abc transporter atp-binding protein FNV66_RS37805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS37810 ENOG4105EB3 Histidine kinase FNV66_RS37835 ENOG4105BZU Histidine kinase FNV66_RS37840 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS37870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FNV66_RS37890 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FNV66_RS37900 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FNV66_RS37905 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FNV66_RS37915 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FNV66_RS37955 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FNV66_RS37960 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FNV66_RS37965 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FNV66_RS37980 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV66_RS38000 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FNV66_RS38015 ENOG4105C9U ATP-dependent DNA helicase RecQ FNV66_RS38030 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FNV66_RS38040 ENOG4105DRR Transcriptional regulator, GntR family FNV66_RS38045 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV66_RS38050 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FNV66_RS38060 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FNV66_RS38075 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS38085 ENOG4107QN1 sodium solute FNV66_RS38090 ENOG4108V9W transcriptional regulatory protein FNV66_RS38100 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FNV66_RS38110 ENOG4108MRH transcriptional regulatory protein FNV66_RS38130 ENOG4105BZN citrate synthase FNV66_RS38150 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FNV66_RS38170 ENOG4105DRR Transcriptional regulator, GntR family FNV66_RS38175 ENOG410849S phosphocarrier protein (HPr) FNV66_RS38180 ENOG4105CD5 CoA-binding domain protein FNV66_RS38195 ENOG4107W53 thymidine kinase FNV66_RS38230 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FNV66_RS38245 ENOG4105F44 Two component transcriptional regulator, winged helix family FNV66_RS38250 ENOG4106F60 Histidine kinase FNV66_RS38275 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FNV66_RS38290 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FNV66_RS38320 ENOG4107VEG TrkA-N domain protein FNV66_RS38325 ENOG4105C0X amino acid FNV66_RS38330 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FNV66_RS38335 ENOG4105C7K acetolactate synthase FNV66_RS38360 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FNV66_RS38390 ENOG4105BZU Histidine kinase FNV66_RS38395 ENOG4105EYF MMPL domain protein FNV66_RS38410 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FNV66_RS38445 ENOG4107S1Q Phosphatase FNV66_RS38460 ENOG4105CEU Arginine dihydrolase FNV66_RS38465 ENOG4105DBV ornithine carbamoyltransferase FNV66_RS38470 ENOG4105CUB amino acid FNV66_RS38480 ENOG4105CGU Enoyl-CoA hydratase FNV66_RS38520 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FNV66_RS38540 ENOG4107QM5 aconitate hydratase FNV66_RS38550 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FNV66_RS38555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS38560 ENOG4105BZU Histidine kinase FNV66_RS38575 ENOG4105CWX Alpha-1,2-mannosidase FNV66_RS38600 ENOG4105E2R ROK family FNV66_RS38605 ENOG4105DFW ABC transporter FNV66_RS38610 ENOG4105C2J ABC transporter FNV66_RS38615 ENOG4108HWW ABC transporter FNV66_RS38620 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FNV66_RS38625 ENOG4105CUB amino acid FNV66_RS38645 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV66_RS38650 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS38655 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FNV66_RS38670 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FNV66_RS38685 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FNV66_RS38695 ENOG4105C1Q protoporphyrinogen oxidase FNV66_RS38700 ENOG4107JTW chlorite dismutase FNV66_RS38720 ENOG4105E18 UPF0276 protein FNV66_RS38755 ENOG4105CSR polyphosphate kinase 2 FNV66_RS38760 ENOG4105C22 threonyL-tRNA synthetase FNV66_RS38775 ENOG4107B2H carbonic anhydrase FNV66_RS38800 ENOG4105DFU Cell wall formation (By similarity) FNV66_RS38805 ENOG4105E0X reductase FNV66_RS38815 ENOG4107TPY serine threonine protein kinase FNV66_RS38860 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding FNV66_RS38900 ENOG4105BZU Histidine kinase FNV66_RS38925 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FNV66_RS38940 ENOG4105EDW glycosyl transferase, family 39 FNV66_RS38970 ENOG4105DHQ Histidine kinase FNV66_RS39065 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FNV66_RS39070 ENOG4105DUM transcriptional regulator, lysR family FNV66_RS39080 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FNV66_RS39110 ENOG4105ZSU inhibitor FNV66_RS39200 ENOG4107S5I aldo keto reductase FNV66_RS39205 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FNV66_RS39225 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FNV66_RS39230 ENOG4108IY8 ABC, transporter FNV66_RS39260 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FNV66_RS39285 ENOG4107RR1 TRANSCRIPTIONal FNV66_RS39290 ENOG4105CSU acyl-Coa dehydrogenase FNV66_RS39305 ENOG4105E7U AraC family transcriptional regulator FNV66_RS39335 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS39360 ENOG4105EBR Carboxylesterase FNV66_RS39365 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FNV66_RS39375 ENOG4108J5H Homocysteine s-methyltransferase FNV66_RS39435 ENOG4108VQT Alpha beta hydrolase fold protein FNV66_RS39545 ENOG4107S9F NmrA family FNV66_RS39635 ENOG4105CJ1 ABC, transporter FNV66_RS39670 ENOG4105QE3 oxidoreductase FNV66_RS39750 ENOG4105CSA Coproporphyrinogen iii oxidase FNV66_RS39760 ENOG4105E6M Sulphatase-modifying factor protein FNV66_RS39770 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FNV66_RS39815 ENOG4105C7K acetolactate synthase FNV66_RS39835 ENOG4105DRR Transcriptional regulator, GntR family FNV66_RS39865 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FNV66_RS39870 ENOG4105C7N Xanthine uracil vitamin C permease FNV66_RS39900 ENOG4108ZJ4 polysaccharide deacetylase FNV66_RS39905 ENOG4105DDC Oxidoreductase domain protein FNV66_RS39925 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) FNV66_RS39930 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FNV66_RS39950 ENOG4105CJ2 (LipO)protein FNV66_RS39965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS39970 ENOG4105BZU Histidine kinase FNV66_RS40010 ENOG4105ECQ AraC Family Transcriptional Regulator FNV66_RS40045 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FNV66_RS40060 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FNV66_RS40065 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FNV66_RS40070 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FNV66_RS40090 ENOG4107SCA Formamidase (EC 3.5.1.49) FNV66_RS40095 ENOG4105IW1 AmiS UreI transporter FNV66_RS40135 ENOG4105D9R oxidoreductase FNV66_RS40140 ENOG4105CPC Aldo Keto reductase FNV66_RS40180 ENOG4105D74 hydrolase FNV66_RS40190 ENOG4105D7N magnesium and cobalt transport protein CorA FNV66_RS40200 ENOG410829K Lysine exporter protein (Lyse ygga) FNV66_RS40205 ENOG4106NZI LysR family Transcriptional regulator FNV66_RS40215 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FNV66_RS40230 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FNV66_RS40235 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS40245 ENOG41060W2 glyoxylate carboligase FNV66_RS40255 ENOG4105CH6 catalase FNV66_RS40260 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV66_RS40265 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FNV66_RS40285 ENOG4105VT2 5-hydroxyisourate hydrolase FNV66_RS40295 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FNV66_RS40315 ENOG4105KVH Transcriptional regulator FNV66_RS40330 ENOG4108ZM9 phosphoglycerate mutase FNV66_RS40335 ENOG4105CHM Aminotransferase FNV66_RS40360 ENOG4105DUU IucA IucC family protein FNV66_RS40370 ENOG4105D9P serine threonine protein kinase FNV66_RS40390 ENOG4107R9S Malate synthase FNV66_RS40395 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FNV66_RS40405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FNV66_RS40420 ENOG4107HP6 Transcriptional regulator FNV66_RS40435 ENOG4105D7N magnesium and cobalt transport protein CorA FNV66_RS40450 ENOG4105CPC Aldo Keto reductase FNV66_RS40455 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS40465 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FNV66_RS40485 ENOG4105CNN ABC, transporter FNV66_RS40490 ENOG4105C2J ABC transporter FNV66_RS40495 ENOG4105DKQ ROK family FNV66_RS40505 ENOG4105C0D helicase FNV66_RS40515 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FNV66_RS40520 ENOG4105E8R UPF0173 metal-dependent hydrolase FNV66_RS40535 ENOG4105CDA abc transporter atp-binding protein FNV66_RS40545 ENOG4105EAD ABC transporter FNV66_RS40550 ENOG4105DRP amino acid AbC transporter FNV66_RS40565 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FNV66_RS40590 ENOG4105C8Y Acetylornithine aminotransferase FNV66_RS40605 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FNV66_RS40615 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FNV66_RS40625 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS40635 ENOG4105BZU Histidine kinase FNV66_RS40640 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS40655 ENOG4105ECY inositol monophosphatase FNV66_RS40670 ENOG4108UVJ appr-1-p processing domain protein FNV66_RS40680 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FNV66_RS40685 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FNV66_RS40695 ENOG4105K64 Glycosyl transferase, family 2 FNV66_RS40705 ENOG4105EQQ protein containing aminopeptidase domain FNV66_RS40720 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FNV66_RS40730 ENOG4105E2K Glycosyl transferase (Group 1 FNV66_RS40750 ENOG4107RRD Dehydrogenase FNV66_RS40755 ENOG4105CAQ asparagine synthetase FNV66_RS40775 ENOG4105C6Y Udp-glucose 6-dehydrogenase FNV66_RS40780 ENOG4105D3Q Sugar transferase FNV66_RS40795 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FNV66_RS40800 ENOG4106NZI LysR family Transcriptional regulator FNV66_RS40810 ENOG4105CBP Major Facilitator FNV66_RS40825 ENOG41060BG Tetr family transcriptional regulator FNV66_RS40860 ENOG4108RQS Two component transcriptional regulator (Winged helix family FNV66_RS40870 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV66_RS40875 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FNV66_RS40885 ENOG4105EB3 Histidine kinase FNV66_RS40890 ENOG4106F60 Histidine kinase FNV66_RS40900 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FNV66_RS40920 ENOG41066UM arsR family transcriptional regulator FNV66_RS40940 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FNV66_RS40985 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FNV66_RS40990 ENOG4108Z6Z Transcriptional regulator FNV66_RS40995 ENOG4105C2U cobyrinic Acid a,c-diamide synthase FNV66_RS41025 ENOG4105BZW Glycerate kinase FNV66_RS41035 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme FNV66_RS41040 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS41050 ENOG4105CI0 Citrate lyase FNV66_RS41065 ENOG4105MWK D-amino acid dehydrogenase, small subunit FNV66_RS41075 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV66_RS41085 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FNV66_RS41095 ENOG4106JDR secreted FNV66_RS41115 ENOG4108Q50 Histidine kinase FNV66_RS41160 ENOG4108ME1 Peptidase M55 D-aminopeptidase FNV66_RS41165 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FNV66_RS41175 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FNV66_RS41205 ENOG4105CV1 Transketolase (EC 2.2.1.1) FNV66_RS41210 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS41220 ENOG4105C5H ABC transporter FNV66_RS41310 ENOG4105CFG Acts as a chaperone (By similarity) FNV66_RS41325 ENOG410842T Pterin carbinolamine dehydratase FNV66_RS41330 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS41345 ENOG4105D29 Helix-turn-helix type 11 domain protein FNV66_RS41350 ENOG4105CX8 fg-gap repeat protein FNV66_RS41360 ENOG4105CYP glycoside hydrolase, family FNV66_RS41370 ENOG41065HY 1,4-beta-cellobiosidase FNV66_RS41390 ENOG4108HMN Caspase domain FNV66_RS41395 ENOG4105EMU Dehydrogenase FNV66_RS41405 ENOG4105CV8 reductase FNV66_RS41430 ENOG4105F5H Glycosyl Hydrolase Family 88 FNV66_RS41440 ENOG4106UDK Cellulose-binding, family II FNV66_RS41465 ENOG4105DUM transcriptional regulator, lysR family FNV66_RS41470 ENOG4105DHU Bile acid FNV66_RS41480 ENOG4108478 ec 3.2.1.18 FNV66_RS41490 ENOG4108VHT MarR family transcriptional regulator FNV66_RS41495 ENOG4105D3W isochorismatase FNV66_RS41505 ENOG4106NZI LysR family Transcriptional regulator FNV66_RS41510 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FNV66_RS41525 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FNV66_RS41530 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FNV66_RS41545 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV66_RS41555 ENOG4105DKQ ROK family FNV66_RS41560 ENOG4105C2J ABC transporter FNV66_RS41565 ENOG4105CNN ABC, transporter FNV66_RS41570 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FNV66_RS41600 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase FNV66_RS41615 ENOG4105F8V Hydrolase, tatD family FNV66_RS41640 ENOG4105FCD Major Facilitator FNV66_RS41660 ENOG4105CMV Succinyl-CoA synthetase subunit beta FNV66_RS41670 ENOG4105C26 Dehydrogenase FNV66_RS41705 ENOG4105BZU Histidine kinase FNV66_RS41730 ENOG4107TXC Transcriptional regulator FNV66_RS41765 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FNV66_RS41780 ENOG4105HFT AraC family transcriptional regulator FNV66_RS41795 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS41810 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands FNV66_RS41820 ENOG4105EMU Dehydrogenase FNV66_RS41830 ENOG4105D9P serine threonine protein kinase FNV66_RS41845 ENOG4105NRA 50s ribosomal protein l31 type b FNV66_RS41855 ENOG4105BZU Histidine kinase FNV66_RS41860 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS41890 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FNV66_RS41895 ENOG4107S2E monooxygenase FNV66_RS41915 ENOG4105CPP Dehydrogenase, E1 component FNV66_RS41920 ENOG4108RZE Tetr family transcriptional regulator FNV66_RS41925 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS41930 ENOG4105CPQ Dehydrogenase FNV66_RS41940 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS41950 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FNV66_RS41955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS41965 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FNV66_RS41995 ENOG4105C0R drug resistance transporter emrb qaca subfamily FNV66_RS42000 ENOG4105CHR reductase FNV66_RS42010 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FNV66_RS42035 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS42040 ENOG410846T CoA-transferase family III FNV66_RS42050 ENOG4108M9J MaoC like domain protein FNV66_RS42065 ENOG4105CPQ Dehydrogenase FNV66_RS42075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS42090 ENOG4106A3M Cytochrome p-450 FNV66_RS42145 ENOG4108YYC ycei family FNV66_RS42155 ENOG4105DRP amino acid AbC transporter FNV66_RS42160 ENOG4105CDA abc transporter atp-binding protein FNV66_RS42165 ENOG4105EAB amino acid AbC transporter FNV66_RS42185 ENOG4105DEN Luciferase family FNV66_RS42190 ENOG4105DEN Luciferase family FNV66_RS42205 ENOG4107TTQ Alpha beta hydrolase fold FNV66_RS42215 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FNV66_RS42240 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FNV66_RS42255 ENOG4107QJN gtp cyclohydrolase ii FNV66_RS42295 ENOG410905P Pyridoxamine 5-phosphate FNV66_RS42310 ENOG4105CSH Transporter FNV66_RS42320 ENOG4107S9B Shikimate dehydrogenase FNV66_RS42340 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FNV66_RS42345 ENOG4108J5G 6-phosphogluconate dehydrogenase FNV66_RS42350 ENOG4107QP8 phosphohexose isomerase FNV66_RS42365 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FNV66_RS42400 ENOG4105CHR reductase FNV66_RS42425 ENOG41088CQ domain protein FNV66_RS42430 ENOG4105CNT hydrolase family 2 FNV66_RS42435 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FNV66_RS42450 ENOG4108MGF sugar kinase FNV66_RS42455 ENOG4105E98 transcriptional regulator DeoR family FNV66_RS42460 ENOG4105F8D glycoside hydrolase family 4 FNV66_RS42470 ENOG4106UDK Cellulose-binding, family II FNV66_RS42535 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FNV66_RS42540 ENOG4107TYH extracellular solute-binding protein family 1 FNV66_RS42545 ENOG4105D81 ABC transporter, permease FNV66_RS42550 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FNV66_RS42600 ENOG4105DP8 Major facilitator superfamily MFS_1 FNV66_RS42635 ENOG4105CPF Cell wall formation (By similarity) FNV66_RS42640 ENOG4108RPX mosc domain containing protein FNV66_RS42645 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FNV66_RS42665 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FNV66_RS42700 ENOG4105E2B Taurine dioxygenase FNV66_RS42725 ENOG4105C7B Threonine dehydratase FNV66_RS42730 ENOG4105CIH Imidazole acetol-phosphate transaminase FNV66_RS42745 ENOG4105CUG Oligopeptidase b FNV66_RS42750 ENOG4105CIF Ornithine Cyclodeaminase FNV66_RS42755 ENOG4105DBV ornithine carbamoyltransferase FNV66_RS42850 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FNV66_RS42855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FNV66_RS42860 ENOG4105CTU Proline racemase FNV66_RS42880 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FNV66_RS42885 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FNV66_RS42890 ENOG4105CG3 alpha amylase, catalytic region FNV66_RS42900 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FNV66_RS42905 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FNV66_RS43045 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FNV66_RS43050 ENOG4105CSH Transporter FNV66_RS43060 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FNV66_RS43065 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FNV66_RS43080 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS43095 ENOG41067TZ transcriptional regulator, MarR family FNV66_RS43105 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FNV66_RS43125 ENOG4105C7B Threonine dehydratase FNV66_RS43135 ENOG4105DQE DNA ligase FNV66_RS43140 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS43155 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FNV66_RS43195 ENOG4106V2I dimethylaminohydrolase FNV66_RS43200 ENOG4105C5H ABC transporter FNV66_RS43210 ENOG4105CR4 methylisocitrate lyase FNV66_RS43215 ENOG4105KF0 sporulation and cell division protein, SsgA FNV66_RS43230 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FNV66_RS43240 ENOG4105EG6 Saccharopine dehydrogenase FNV66_RS43245 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FNV66_RS43250 ENOG4105DYW oxidoreductase FNV66_RS43255 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS43260 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS43265 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV66_RS43285 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FNV66_RS43310 ENOG4105C5H ABC transporter FNV66_RS43320 ENOG4105BZM domain protein FNV66_RS43340 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS43355 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FNV66_RS43360 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FNV66_RS43385 ENOG4108MDK Dehydrogenase FNV66_RS43405 ENOG4105EY8 ABC transporter FNV66_RS43410 ENOG4105FBD synthase FNV66_RS43420 ENOG4107S11 squalene-associated FAD-dependent desaturase FNV66_RS43430 ENOG4105EWU Squalene--hopene cyclase FNV66_RS43445 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FNV66_RS43470 ENOG4105M2Z protein tyrosine serine phosphatase FNV66_RS43485 ENOG4105CX8 fg-gap repeat protein FNV66_RS43495 ENOG41090WU lipolytic protein G-D-S-L family FNV66_RS43510 ENOG4105D82 Glutamate dehydrogenase FNV66_RS43515 ENOG4105C7K acetolactate synthase FNV66_RS43550 ENOG4105CPQ Dehydrogenase FNV66_RS43555 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FNV66_RS43560 ENOG4106NZI LysR family Transcriptional regulator FNV66_RS43620 ENOG4105BZ1 (ABC) transporter FNV66_RS43650 ENOG4105C0F tryptophanase EC 4.1.99.1 FNV66_RS43670 ENOG4105XTG Pfam:DUF156 FNV66_RS43690 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) FNV66_RS43720 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold FNV66_RS43830 ENOG4105DWF phosphomethylpyrimidine kinase FNV66_RS43835 ENOG4105ECR NmrA family FNV66_RS43885 ENOG4108KPJ rna polymerase sigma factor FNV66_RS43895 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FNV66_RS43910 ENOG4108ZHJ Organic hydroperoxide resistance protein FNV66_RS43915 ENOG4108KPJ rna polymerase sigma factor FNV66_RS43970 ENOG41079R3 acyl carrier protein FNV66_RS43980 ENOG4105KTE polyketide synthesis cyclase FNV66_RS43995 ENOG4105E9K Isocitrate dehydrogenase FNV66_RS44000 ENOG4105D64 Mechanosensitive ion channel FNV66_RS44005 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS44020 ENOG4105EYF MMPL domain protein FNV66_RS44030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FNV66_RS44040 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FNV66_RS44055 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FNV66_RS44070 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FNV66_RS44090 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FNV66_RS44105 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FNV66_RS44130 ENOG4105CM2 brancheD-chain amino acid aminotransferase FNV66_RS44135 ENOG4105C5I Dehydrogenase FNV66_RS44150 ENOG4105CIH Imidazole acetol-phosphate transaminase FNV66_RS44160 ENOG4105T38 integral membrane protein FNV66_RS44165 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FNV66_RS44175 ENOG4105D5U fad dependent oxidoreductase FNV66_RS44185 ENOG4108Z4U Ferredoxin FNV66_RS44190 ENOG4105C5Q Transcriptional regulator FNV66_RS44225 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FNV66_RS44240 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FNV66_RS44260 ENOG4107QPH glycogen) synthase FNV66_RS44265 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FNV66_RS44285 ENOG4105FQP Beta-lactamase FNV66_RS44290 ENOG4108R85 Short chain dehydrogenase FNV66_RS44300 ENOG4108M4U conserved membrane protein FNV66_RS44335 ENOG41060NJ transcriptional regulator FNV66_RS44370 ENOG41073TP transcriptional regulator FNV66_RS44380 ENOG4105C2J ABC transporter FNV66_RS44390 ENOG4105DIA mandelate racemase muconate lactonizing FNV66_RS44395 ENOG4105CHR reductase FNV66_RS44460 ENOG4105CRK lysyL-tRNA synthetase FNV66_RS44465 ENOG4108ZJ4 polysaccharide deacetylase FNV66_RS44505 ENOG4105BZU Histidine kinase FNV66_RS44510 ENOG4108R85 Short chain dehydrogenase FNV66_RS44515 ENOG4105C5Q Transcriptional regulator FNV66_RS44530 ENOG4105E33 succinate dehydrogenase FNV66_RS44550 ENOG4105DEN Luciferase family FNV66_RS44570 ENOG4105CPC Aldo Keto reductase FNV66_RS44605 ENOG4105DU6 RNA polymerase FNV66_RS44645 ENOG4105F27 Major Facilitator FNV66_RS44650 ENOG4108KB2 LysR family Transcriptional regulator FNV66_RS44655 ENOG4107RSM transcriptional regulator FNV66_RS44665 ENOG4105ENX hydrolase FNV66_RS44670 ENOG4105C7W Xanthine dehydrogenase FNV66_RS44675 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FNV66_RS44680 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FNV66_RS44695 ENOG4107SET aldo keto reductase FNV66_RS44725 ENOG41067HS methyltransferase FNV66_RS44730 ENOG4108V75 Glutamine amidotransferase FNV66_RS44735 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process FNV66_RS44740 ENOG4105D1K glutamate--cysteine ligase FNV66_RS44755 ENOG4105DZ6 Band 7 protein FNV66_RS44770 ENOG41060NJ transcriptional regulator FNV66_RS44785 ENOG41080RH Thioredoxin FNV66_RS44795 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FNV66_RS44840 ENOG4105EUB pirin domain protein FNV66_RS44880 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV66_RS44895 ENOG4107RN3 metallophosphoesterase FNV66_RS44900 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS44940 ENOG4105D29 Helix-turn-helix type 11 domain protein FNV66_RS44965 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS44980 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FNV66_RS45025 ENOG4105FP9 thiamine pyrophosphate FNV66_RS45030 ENOG4105CHR reductase FNV66_RS45035 ENOG4108XG4 DNA-binding transcriptional regulator FNV66_RS45040 ENOG4105E1F short-chain dehydrogenase reductase FNV66_RS45050 ENOG4105DMF Dehydrogenase FNV66_RS45065 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FNV66_RS45070 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FNV66_RS45105 ENOG4105CR4 methylisocitrate lyase FNV66_RS45145 ENOG4105KVH Transcriptional regulator FNV66_RS45160 ENOG4105F6J Alpha beta hydrolase fold FNV66_RS45170 ENOG4105CIG ABC transporter FNV66_RS45210 ENOG4108M0I Transcriptional regulator FNV66_RS45215 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FNV66_RS45240 ENOG4105F95 Monooxygenase FNV66_RS45245 ENOG4105CPC Aldo Keto reductase FNV66_RS45250 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV66_RS45285 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS45315 ENOG41061ZR Transcriptional regulator FNV66_RS45340 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FNV66_RS45390 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FNV66_RS45400 ENOG4105CWX Alpha-1,2-mannosidase FNV66_RS45425 ENOG4108M8W Monooxygenase FNV66_RS45445 ENOG4105CSH Transporter FNV66_RS45465 ENOG4107T6F Xaa-Pro aminopeptidase FNV66_RS45470 ENOG4107MM9 BNR Asp-box repeat-containing protein FNV66_RS45480 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FNV66_RS45490 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS45495 ENOG4105T1M mycothiol conjugate amidase mca FNV66_RS45520 ENOG4105J0Q Transcriptional regulator FNV66_RS45525 ENOG4105CIS alcohol dehydrogenase FNV66_RS45530 ENOG4108JJB ABC transporter FNV66_RS45535 ENOG4108JJB ABC transporter FNV66_RS45540 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FNV66_RS45565 ENOG410667J hydrolase FNV66_RS45640 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FNV66_RS45645 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FNV66_RS45650 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FNV66_RS45655 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FNV66_RS45660 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FNV66_RS45665 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FNV66_RS45675 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS45685 ENOG4108ZJI phenylacetic acid degradation protein FNV66_RS45695 ENOG4106T9R serine protease FNV66_RS45700 ENOG4107QTZ amino acid FNV66_RS45770 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FNV66_RS45800 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FNV66_RS45810 ENOG4105DPX Hydrogenase, large subunit FNV66_RS45840 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FNV66_RS45860 ENOG4105CQS hydrogenase expression formation protein HypD FNV66_RS45880 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FNV66_RS45895 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein FNV66_RS45925 ENOG4105C19 ABC transporter FNV66_RS45930 ENOG4105E90 ABC transporter FNV66_RS45935 ENOG4105E90 ABC transporter FNV66_RS45945 ENOG4108TM9 integral membrane protein FNV66_RS45955 ENOG4108IJ8 ABC transporter FNV66_RS45960 ENOG41080R8 Conserved Protein FNV66_RS45965 ENOG4107QR9 Iron-sulfur cluster binding protein FNV66_RS45970 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FNV66_RS45975 ENOG4105DET Rhamnulokinase FNV66_RS45990 ENOG4105C2J ABC transporter FNV66_RS46005 ENOG4105D4B ABC, transporter FNV66_RS46020 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS46030 ENOG4108KPJ rna polymerase sigma factor FNV66_RS46035 ENOG4105DDN Pentapeptide repeat-containing protein FNV66_RS46040 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FNV66_RS46045 ENOG4108R86 Transcriptional regulator FNV66_RS46055 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FNV66_RS46095 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FNV66_RS46110 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FNV66_RS46155 ENOG4105DCG PHP domain protein FNV66_RS46205 ENOG4105NAE bifunctional deaminase-reductase domain protein FNV66_RS46230 ENOG4107TPY serine threonine protein kinase FNV66_RS46275 ENOG41082SX arsR family transcriptional regulator FNV66_RS46280 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FNV66_RS46285 ENOG4105CNI cell division protein FtsW FNV66_RS46310 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FNV66_RS46315 ENOG4107TB5 TRANSCRIPTIONal FNV66_RS46325 ENOG4105VEQ Cold shock protein FNV66_RS46360 ENOG4105CJA serine threonine protein kinase FNV66_RS46390 ENOG4107QTZ amino acid FNV66_RS46480 ENOG4105KF0 sporulation and cell division protein, SsgA FNV66_RS46530 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS46535 ENOG4105C2J ABC transporter FNV66_RS46540 ENOG4105CNN ABC, transporter FNV66_RS46545 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator FNV66_RS46560 ENOG4108HKT sucrose-6-phosphate hydrolase FNV66_RS46610 ENOG4105KNA -acetyltransferase FNV66_RS46665 ENOG4108Q50 Histidine kinase FNV66_RS46685 ENOG4108Z6Z Transcriptional regulator FNV66_RS46705 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FNV66_RS46830 ENOG4105ETX regulatoR FNV66_RS46880 ENOG4107R16 Multicopper oxidase FNV66_RS46900 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FNV66_RS46920 ENOG4105C26 Dehydrogenase FNV66_RS46935 ENOG4105ECQ AraC Family Transcriptional Regulator FNV66_RS46960 ENOG4107RCI amp-dependent synthetase and ligase FNV66_RS46970 ENOG4105CUB amino acid FNV66_RS47010 ENOG4106YKD Cytochrome p-450 FNV66_RS47050 ENOG4105EBM Alpha Beta Hydrolase Fold protein FNV66_RS47055 ENOG4107SM8 Adenylate Guanylate cyclase FNV66_RS47085 ENOG4105CNT hydrolase family 2 FNV66_RS47090 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FNV66_RS47115 ENOG41082BM Transcriptional regulator, arsr family FNV66_RS47150 ENOG4108JQ1 Dehydrogenase FNV66_RS47155 ENOG4105DMF Dehydrogenase FNV66_RS47180 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FNV66_RS47190 ENOG4106C4P Strong inhibitor of bacterial serine proteases such as subtilisin (By similarity) FNV66_RS47200 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FNV66_RS47210 ENOG41060NJ transcriptional regulator FNV66_RS47225 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FNV66_RS47245 ENOG4108JJA ABC, transporter FNV66_RS47250 ENOG4108JJA ABC, transporter FNV66_RS47285 ENOG4105EXC Acyl-transferase FNV66_RS47300 ENOG4105XRQ Xanthine dehydrogenase accessory factor FNV66_RS47350 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FNV66_RS47365 ENOG4105BZ9 Cytochrome C oxidase, subunit I FNV66_RS47380 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FNV66_RS47410 ENOG4105DFW ABC transporter FNV66_RS47455 ENOG4105C5X domain protein FNV66_RS47460 ENOG4105CHR reductase FNV66_RS47490 ENOG4105E2R ROK family FNV66_RS47510 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FNV66_RS47535 ENOG4108KPJ rna polymerase sigma factor FNV66_RS47580 ENOG4105EQX glucarate dehydratase FNV66_RS47590 ENOG4107RSM transcriptional regulator FNV66_RS47610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV66_RS47685 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV66_RS47690 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FNV66_RS47695 ENOG4107R13 MMPL domain protein FNV66_RS47730 ENOG4105CHR reductase FNV66_RS47735 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV66_RS47750 ENOG41068HZ 50S ribosomal protein L32 FNV66_RS47795 ENOG4108PVQ transcriptional regulator FNV66_RS47855 ENOG4105JAB phenazine biosynthesis protein, phzf family FNV66_RS47865 ENOG4107RSM transcriptional regulator FNV66_RS47885 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FNV66_RS47920 ENOG4105VEQ Cold shock protein FNV66_RS47945 ENOG4105DEG Vwa containing coxe family protein FNV66_RS47980 ENOG4108JPW Aminotransferase FNV66_RS47990 ENOG4105FQP Beta-lactamase FNV66_RS48015 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FNV66_RS48030 ENOG41066F8 ROK family FNV66_RS48040 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FNV66_RS48045 ENOG4105DRS transport system, permease FNV66_RS48075 ENOG4105K4I Scp-like extracellular FNV66_RS48115 ENOG4105EGE secreted protein FNV66_RS48120 ENOG4106UDK Cellulose-binding, family II FNV66_RS48140 ENOG4107SET aldo keto reductase FNV66_RS48145 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FNV66_RS48150 ENOG4105CWX Alpha-1,2-mannosidase FNV66_RS48195 ENOG4108R85 Short chain dehydrogenase FNV66_RS48200 ENOG4105D2B acyl-CoA dehydrogenase FNV66_RS48205 ENOG4105E39 Enoyl-CoA hydratase FNV66_RS48220 ENOG4105CC9 acyl-Coa dehydrogenase FNV66_RS48230 ENOG4105C1G acyl-Coa dehydrogenase FNV66_RS48235 ENOG4105CHR reductase FNV66_RS48240 ENOG4105CHR reductase FNV66_RS48245 ENOG4108UKI Enoyl-CoA hydratase FNV66_RS48275 ENOG4105C5X domain protein FNV66_RS48290 ENOG4105CI2 imidazolone-5-propionate hydrolase FNV66_RS48295 ENOG4107TPY serine threonine protein kinase FNV66_RS48330 ENOG41082J7 Rhodanese domain protein FNV66_RS48335 ENOG4108VCT Sulfite exporter TauE/SafE FNV66_RS48340 ENOG4105VPX protein, conserved in bacteria FNV66_RS48380 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FNV66_RS48395 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS48405 ENOG4105EX0 alpha-galactosidase FNV66_RS48415 ENOG4107S5I aldo keto reductase FNV66_RS48420 ENOG4105CHJ isochorismatase hydrolase FNV66_RS48440 ENOG4105CUX Signal transduction histidine kinase FNV66_RS48445 ENOG4105C3M thioredoxin reductase FNV66_RS48475 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FNV66_RS48485 ENOG4105F27 Major Facilitator FNV66_RS48510 ENOG4105IDI abc transporter atp-binding protein FNV66_RS48545 ENOG4105DR5 peptidase FNV66_RS48570 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FNV66_RS48585 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS48595 ENOG4105C4C beta-galactosidase FNV66_RS48620 ENOG4105D3W isochorismatase FNV66_RS48635 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FNV66_RS48650 ENOG4105BZU Histidine kinase FNV66_RS48665 ENOG4108U3T pfkb domain protein FNV66_RS48670 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FNV66_RS48730 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) FNV66_RS48735 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FNV66_RS48765 ENOG4108KPJ rna polymerase sigma factor FNV66_RS48785 ENOG4108KXV response regulator FNV66_RS48805 ENOG4108W9H Tetr family transcriptional regulator FNV66_RS48825 ENOG4105C7W Xanthine dehydrogenase FNV66_RS48850 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS48875 ENOG4105BZU Histidine kinase FNV66_RS48885 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FNV66_RS48930 ENOG4105CSR polyphosphate kinase 2 FNV66_RS48935 ENOG4107QRI Phosphoketolase FNV66_RS48940 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FNV66_RS48960 ENOG4105CD5 CoA-binding domain protein FNV66_RS48965 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FNV66_RS48985 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FNV66_RS49000 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FNV66_RS49025 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FNV66_RS49035 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FNV66_RS49050 ENOG4105CJW magnesium transporter FNV66_RS49090 ENOG41068KF Universal stress protein FNV66_RS49105 ENOG4105E2A Dehydrogenase FNV66_RS49120 ENOG4105D5Q Arginine ornithine antiporter FNV66_RS49125 ENOG4105CEU Arginine dihydrolase FNV66_RS49130 ENOG4105DBV ornithine carbamoyltransferase FNV66_RS49145 ENOG4105F1A Pyruvate formate-lyase FNV66_RS49175 ENOG4105E1F short-chain dehydrogenase reductase FNV66_RS49190 ENOG4105VEQ Cold shock protein FNV66_RS49195 ENOG4105C1J atp-dependent rna helicase FNV66_RS49245 ENOG4105BZ1 (ABC) transporter FNV66_RS49290 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FNV66_RS49300 ENOG4105S7M extracellular small neutral protease FNV66_RS49315 ENOG4105VUF Transcriptional regulator FNV66_RS49345 ENOG4105BZ1 (ABC) transporter FNV66_RS49385 ENOG4107RDT Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FNV66_RS49390 ENOG4107HP6 Transcriptional regulator FNV66_RS49400 ENOG4105CYP glycoside hydrolase, family FNV66_RS49405 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FNV66_RS49410 ENOG4105HSS phospholipase C FNV66_RS49435 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FNV66_RS49440 ENOG4105CHJ isochorismatase hydrolase FNV66_RS49455 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein FNV66_RS49520 ENOG4108MJI response regulator FNV66_RS49530 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV66_RS49535 ENOG41066YJ Beta-lactamase FNV66_RS49565 ENOG4105CHR reductase FNV66_RS49570 ENOG4105SKE transcriptional Regulator LysR family FNV66_RS49575 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FNV66_RS49610 ENOG4105EZR dyp-type peroxidase family protein FNV66_RS49620 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV66_RS49635 ENOG4105CF7 AraC family transcriptional regulator FNV66_RS49645 ENOG4108KXV response regulator FNV66_RS49650 ENOG41065SU Two-component system sensor kinase FNV66_RS49670 ENOG4105MHT Transcriptional regulator, ARSR family FNV66_RS49685 ENOG4108MP6 LysR family Transcriptional regulator FNV66_RS49745 ENOG41061H0 Monooxygenase FNV66_RS49750 ENOG4108IND Tetr family transcriptional regulator FNV66_RS49765 ENOG4105DQ4 alcohol dehydrogenase FNV66_RS49780 ENOG4105CNN ABC, transporter FNV66_RS49785 ENOG4105C2J ABC transporter FNV66_RS49795 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FNV66_RS49805 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS49810 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FNV66_RS49830 ENOG4105DC8 reductase FNV66_RS49850 ENOG4105CHR reductase FNV66_RS49855 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FNV66_RS49880 ENOG4105C5X domain protein FNV66_RS49895 ENOG4105F7P transcriptional regulator AsnC family FNV66_RS49935 ENOG4105EUB pirin domain protein FNV66_RS49940 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV66_RS49965 ENOG4105EMN RNA polymerase sigma factor FNV66_RS49995 ENOG4105D74 hydrolase FNV66_RS50010 ENOG4105E5D amino acid FNV66_RS50025 ENOG4105E1F short-chain dehydrogenase reductase FNV66_RS50030 ENOG4107GJV short-chain dehydrogenase reductase FNV66_RS50055 ENOG4105CHP RNA polymerase FNV66_RS50060 ENOG4105GRZ Ycii-related protein FNV66_RS50110 ENOG4108JGH Tetr family transcriptional regulator FNV66_RS50115 ENOG4107S5I aldo keto reductase FNV66_RS50145 ENOG4106A3M Cytochrome p-450 FNV66_RS50170 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS50200 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS50205 ENOG4105BZU Histidine kinase FNV66_RS50210 ENOG4105HHS UPF0256 protein FNV66_RS50250 ENOG4108YIQ Alpha beta hydrolase FNV66_RS50270 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS50285 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV66_RS50290 ENOG4105C26 Dehydrogenase FNV66_RS50295 ENOG4105C1B dTDP-glucose 4-6-dehydratase FNV66_RS50305 ENOG4105DEN Luciferase family FNV66_RS50310 ENOG4108IG5 Transcriptional regulator FNV66_RS50325 ENOG4107RSM transcriptional regulator FNV66_RS50330 ENOG4105FGE Short-chain dehydrogenase reductase Sdr FNV66_RS50350 ENOG4105ETX regulatoR FNV66_RS50440 ENOG4105XEA Tetr family transcriptional regulator FNV66_RS50450 ENOG4108JGH Tetr family transcriptional regulator FNV66_RS50510 ENOG4105C26 Dehydrogenase FNV66_RS50520 ENOG4108YIQ Alpha beta hydrolase FNV66_RS50590 ENOG4105EYF MMPL domain protein FNV66_RS50600 ENOG4105H3G oxidoreductase FNV66_RS50605 ENOG4105CHR reductase FNV66_RS50610 ENOG4105C26 Dehydrogenase FNV66_RS50615 ENOG4108ZX5 transcriptional regulator FNV66_RS50630 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FNV66_RS50680 ENOG4105ECQ AraC Family Transcriptional Regulator FNV66_RS50690 ENOG4105C26 Dehydrogenase FNV66_RS50725 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS50755 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FNV66_RS50785 ENOG4105EMU Dehydrogenase FNV66_RS50810 ENOG4105C57 major facilitator superfamily FNV66_RS50815 ENOG4105C57 major facilitator superfamily FNV66_RS50835 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS50865 ENOG4105CPC Aldo Keto reductase FNV66_RS50880 ENOG4108W6C Dehydrogenase FNV66_RS50915 ENOG4108WYP Transcriptional regulator FNV66_RS50920 ENOG4105BZU Histidine kinase FNV66_RS50925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FNV66_RS50930 ENOG4105EYF MMPL domain protein FNV66_RS51050 ENOG4105Y3U Transglycosylase-associated protein FNV66_RS51055 ENOG41082SX arsR family transcriptional regulator FNV66_RS51060 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FNV66_RS51120 ENOG4105ERH Fumarylacetoacetate hydrolase FNV66_RS51135 ENOG41061H0 Monooxygenase FNV66_RS51155 ENOG4105D2S major facilitator superfamily FNV66_RS51160 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FNV66_RS51175 ENOG4105HS2 Arsenate reductase FNV66_RS51255 ENOG4105ECQ AraC Family Transcriptional Regulator FNV66_RS51335 ENOG4105KNA -acetyltransferase FNV66_RS51405 ENOG4105EBR Carboxylesterase FNV66_RS51415 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS51485 ENOG4105EDW glycosyl transferase, family 39 FNV66_RS51540 ENOG4105D5G Transposase FNV66_RS51565 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FNV66_RS51625 ENOG4105BZU Histidine kinase FNV66_RS51650 ENOG4108RAV Conserved protein FNV66_RS51660 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FNV66_RS51725 ENOG4108IND Tetr family transcriptional regulator FNV66_RS51805 ENOG4108XXK NUDIX hydrolase FNV66_RS51815 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FNV66_RS51860 ENOG4105C6Y Udp-glucose 6-dehydrogenase FNV66_RS51885 ENOG4105MWK D-amino acid dehydrogenase, small subunit FNV66_RS51890 ENOG4105ECY inositol monophosphatase FNV66_RS51895 ENOG4105G2Y Transcriptional regulator FNV66_RS51905 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FNV66_RS51945 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FNV66_RS51985 ENOG4105KHM amidohydrolase 2 FNV66_RS52000 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FNV66_RS52005 ENOG4105D5G Transposase FNV66_RS52040 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS52080 ENOG4108BUD transposase FNV66_RS52085 ENOG4107QZI cell division protein FtsK FNV66_RS52135 ENOG4106IJN integrase catalytic domain-containing protein FNV66_RS52140 ENOG4105F5W AtP-binding protein FNV66_RS52220 ENOG4108IG5 Transcriptional regulator FNV66_RS52235 ENOG4105VNT transposase (IS4 family) protein FNV66_RS52305 ENOG4105D8K carboxyl transferase FNV66_RS52315 ENOG4105D7V transposase FNV66_RS52325 ENOG4107SQU synthase FNV66_RS52345 ENOG4105CEY Amp-dependent synthetase and ligase FNV66_RS52350 ENOG4105WH1 Two component transcriptional regulator luxr family FNV66_RS52380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FNV66_RS52385 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FNV66_RS52390 ENOG4105CHR reductase FNV66_RS52395 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FNV66_RS52405 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FNV66_RS52410 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FNV66_RS52420 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FNV66_RS52430 ENOG4105CPC Aldo Keto reductase FNV66_RS52445 ENOG4108IQE Amp-dependent synthetase and ligase FNV66_RS52480 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FNV66_RS52540 ENOG4107V9E glucose-1-phosphate thymidylyltransferase FNV66_RS52570 ENOG4105CHJ isochorismatase hydrolase FNV66_RS52575 ENOG4105XPP Protein of unknown function (DUF1275) FNV66_RS52615 ENOG41085W3 Transposase FNV66_RS52665 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FNV66_RS52685 ENOG4105C9B Cysteine desulfurase FNV66_RS52755 ENOG4105ECQ AraC Family Transcriptional Regulator FNV66_RS52760 ENOG4105BZP glycoside hydrolase 15-related FNV66_RS52770 ENOG4105BZU Histidine kinase FNV66_RS52805 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FNV66_RS52875 ENOG4107R33 ppx gppa phosphatase FNV66_RS52985 ENOG4105KNA -acetyltransferase FNV66_RS53055 ENOG4105ECQ AraC Family Transcriptional Regulator FNV66_RS53120 ENOG4105E7U AraC family transcriptional regulator FNV66_RS53185 ENOG4106NZI LysR family Transcriptional regulator FNV66_RS53260 ENOG4108KC1 acyl-Coa dehydrogenase FNV66_RS53265 ENOG4107RQ0 Maleylacetate reductase FNV66_RS53280 ENOG4107RSM transcriptional regulator FNV66_RS53285 ENOG4105CHU acetyl-coa acetyltransferase FNV66_RS53295 ENOG4107QNJ CoA-transferase subunit B FNV66_RS53310 ENOG4105H1N peptidase, M24 FNV66_RS53315 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FNV66_RS53325 ENOG4105D7V transposase FNV66_RS53330 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS53345 ENOG4108JYK Dehydrogenase FNV66_RS53365 ENOG4105KNA -acetyltransferase FNV66_RS53370 ENOG4105ETE Transcriptional regulator (LacI family FNV66_RS53390 ENOG4105C0Z ABC transporter FNV66_RS53395 ENOG4105CJ1 ABC, transporter FNV66_RS53405 ENOG4105C32 Amino acid ABC transporter (Permease) FNV66_RS53420 ENOG4105CHJ isochorismatase hydrolase FNV66_RS53425 ENOG4105XPP Protein of unknown function (DUF1275) FNV66_RS53460 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FNV66_RS53470 ENOG4105D7T ABC transporter FNV66_RS53480 ENOG4108YYC ycei family FNV66_RS53485 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FNV66_RS53525 ENOG4105KF0 sporulation and cell division protein, SsgA FNV66_RS53545 ENOG4108BUD transposase FNV66_RS53560 ENOG4105KF0 sporulation and cell division protein, SsgA FNV66_RS53590 ENOG4105CBC glutamate synthase FNV66_RS53710 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FNV66_RS53720 ENOG4107SID ATP-dependent exodnase (exonuclease v) FNV66_RS53805 ENOG4108JDX DNA polymerase iii, epsilon subunit FNV66_RS53930 ENOG4105D9P serine threonine protein kinase