locus-tag	class	description
FNV66_RS00020	COG1278	Cold shock
FNV66_RS00080	COG1733	regulation of RNA biosynthetic process
FNV66_RS00175	COG0305	Participates in initiation and elongation during chromosome replication
FNV66_RS00180	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FNV66_RS00205	COG0252	asparaginase activity
FNV66_RS00375	COG1051	belongs to the nudix hydrolase family
FNV66_RS00385	COG4974	Belongs to the 'phage' integrase family
FNV66_RS00490	COG0587	DNA-directed DNA polymerase activity
FNV66_RS00495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV66_RS00620	COG1088	dTDP-glucose 4,6-dehydratase activity
FNV66_RS00890	COG1088	dTDP-glucose 4,6-dehydratase activity
FNV66_RS00915	COG1652	LysM domain
FNV66_RS01190	COG1192	Involved in chromosome partitioning
FNV66_RS01385	COG1278	Cold shock
FNV66_RS01435	COG0494	nUDIX hydrolase
FNV66_RS01505	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV66_RS01510	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FNV66_RS01525	COG2197	response regulator
FNV66_RS01555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FNV66_RS01560	COG0596	Alpha beta hydrolase
FNV66_RS01615	COG0596	Alpha beta hydrolase
FNV66_RS01675	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FNV66_RS01805	COG3547	Transposase (IS116 IS110 IS902 family)
FNV66_RS01880	COG1959	2 iron, 2 sulfur cluster binding
FNV66_RS01930	COG0477	Major facilitator Superfamily
FNV66_RS02050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FNV66_RS02060	COG1733	regulation of RNA biosynthetic process
FNV66_RS02065	COG0604	alcohol dehydrogenase
FNV66_RS02065	COG4221	oxidoreductase activity
FNV66_RS02065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV66_RS02065	COG3321	synthase
FNV66_RS02085	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV66_RS02170	COG0659	secondary active sulfate transmembrane transporter activity
FNV66_RS02180	COG2824	Alkylphosphonate utilization operon protein PhnA
FNV66_RS02235	COG1136	(ABC) transporter
FNV66_RS02275	COG0456	acetyltransferase
FNV66_RS02350	COG2197	response regulator
FNV66_RS02385	COG0114	fumarate hydratase activity
FNV66_RS02390	COG0281	malic enzyme
FNV66_RS02395	COG3842	ATPase activity
FNV66_RS02400	COG1178	ABC-type Fe3 transport system permease component
FNV66_RS02410	COG2409	Drug exporters of the RND superfamily
FNV66_RS02420	COG0745	RESPONSE REGULATOR receiver
FNV66_RS02425	COG2205	protein histidine kinase activity
FNV66_RS02480	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS02495	COG1073	alpha beta
FNV66_RS02505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FNV66_RS02525	COG0671	phosphoesterase, PA-phosphatase related
FNV66_RS02540	COG2814	Major facilitator Superfamily
FNV66_RS02560	COG0726	polysaccharide deacetylase
FNV66_RS02565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FNV66_RS02575	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV66_RS02580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV66_RS02620	COG2267	carboxylic ester hydrolase activity
FNV66_RS02685	COG4585	Histidine kinase
FNV66_RS02690	COG2197	response regulator
FNV66_RS02705	COG1278	Cold shock
FNV66_RS02720	COG0596	Alpha beta hydrolase
FNV66_RS02775	COG3903	Transcriptional regulator
FNV66_RS02775	COG3629	intracellular signal transduction
FNV66_RS02795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FNV66_RS02825	COG0583	DNA-binding transcription factor activity
FNV66_RS02840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FNV66_RS02855	COG0640	Transcriptional regulator
FNV66_RS02885	COG1609	Transcriptional regulator
FNV66_RS02890	COG2723	6-phospho-beta-galactosidase activity
FNV66_RS02920	COG3250	beta-galactosidase activity
FNV66_RS02925	COG3250	beta-galactosidase activity
FNV66_RS02940	COG3507	Belongs to the glycosyl hydrolase 43 family
FNV66_RS02950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV66_RS02960	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS03045	COG3290	protein histidine kinase activity
FNV66_RS03065	COG1131	(ABC) transporter
FNV66_RS03075	COG1595	DNA-templated transcription, initiation
FNV66_RS03150	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FNV66_RS03160	COG1309	transcriptional regulator
FNV66_RS03230	COG0745	RESPONSE REGULATOR receiver
FNV66_RS03235	COG2205	protein histidine kinase activity
FNV66_RS03255	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FNV66_RS03275	COG4585	Histidine kinase
FNV66_RS03280	COG2197	response regulator
FNV66_RS03285	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS03310	COG1090	epimerase
FNV66_RS03315	COG1595	DNA-templated transcription, initiation
FNV66_RS03330	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV66_RS03340	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS03380	COG0778	Nitroreductase
FNV66_RS03385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV66_RS03420	COG1063	alcohol dehydrogenase
FNV66_RS03425	COG2124	cytochrome p450
FNV66_RS03425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FNV66_RS03485	COG0656	L-ascorbic acid biosynthetic process
FNV66_RS03505	COG3344	reverse transcriptase
FNV66_RS03680	COG2890	protein-(glutamine-N5) methyltransferase activity
FNV66_RS03700	COG0069	glutamate synthase activity
FNV66_RS03705	COG0028	Belongs to the TPP enzyme family
FNV66_RS03710	COG0596	Alpha beta hydrolase
FNV66_RS03720	COG1366	Belongs to the anti-sigma-factor antagonist family
FNV66_RS03730	COG0277	FAD linked oxidase domain protein
FNV66_RS03735	COG1024	Enoyl-CoA hydratase
FNV66_RS03750	COG4569	acetaldehyde dehydrogenase (acetylating) activity
FNV66_RS03765	COG1120	ATPase activity
FNV66_RS03770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV66_RS03780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV66_RS03785	COG1535	isochorismatase
FNV66_RS03785	COG3433	isochorismatase activity
FNV66_RS03805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV66_RS03860	COG2226	methyltransferase
FNV66_RS03875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FNV66_RS03895	COG1522	sequence-specific DNA binding
FNV66_RS03910	COG0667	Aldo Keto reductase
FNV66_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS03955	COG3537	Alpha-1,2-mannosidase
FNV66_RS03965	COG1309	transcriptional regulator
FNV66_RS03970	COG3619	membrane
FNV66_RS03975	COG0583	DNA-binding transcription factor activity
FNV66_RS03980	COG3876	Protein conserved in bacteria
FNV66_RS03995	COG1175	transmembrane transport
FNV66_RS04000	COG0395	ABC-type sugar transport system, permease component
FNV66_RS04010	COG1902	pentaerythritol trinitrate reductase activity
FNV66_RS04030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV66_RS04040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV66_RS04050	COG1073	alpha beta
FNV66_RS04055	COG1024	Enoyl-CoA hydratase
FNV66_RS04065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FNV66_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS04115	COG1309	transcriptional regulator
FNV66_RS04120	COG0655	NAD(P)H dehydrogenase (quinone) activity
FNV66_RS04130	COG1733	regulation of RNA biosynthetic process
FNV66_RS04145	COG1309	transcriptional regulator
FNV66_RS04165	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS04170	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS04180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS04190	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS04200	COG1024	Enoyl-CoA hydratase
FNV66_RS04205	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS04210	COG1309	transcriptional regulator
FNV66_RS04215	COG0667	Aldo Keto reductase
FNV66_RS04220	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FNV66_RS04245	COG0800	Aldolase
FNV66_RS04255	COG4948	Mandelate Racemase Muconate Lactonizing
FNV66_RS04275	COG0395	ABC-type sugar transport system, permease component
FNV66_RS04280	COG1175	transmembrane transport
FNV66_RS04290	COG3345	alpha-galactosidase
FNV66_RS04295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FNV66_RS04325	COG1309	transcriptional regulator
FNV66_RS04365	COG0366	Alpha amylase catalytic
FNV66_RS04395	COG0583	DNA-binding transcription factor activity
FNV66_RS04405	COG2197	response regulator
FNV66_RS04420	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV66_RS04435	COG2207	Transcriptional regulator
FNV66_RS04440	COG2223	nitrite transmembrane transporter activity
FNV66_RS04470	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS04495	COG1609	Transcriptional regulator
FNV66_RS04515	COG0395	ABC-type sugar transport system, permease component
FNV66_RS04565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FNV66_RS04580	COG0488	(ABC) transporter
FNV66_RS04585	COG0488	(ABC) transporter
FNV66_RS04640	COG1764	response to oxidative stress
FNV66_RS04670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FNV66_RS04695	COG0477	Major facilitator Superfamily
FNV66_RS04745	COG0519	Catalyzes the synthesis of GMP from XMP
FNV66_RS04745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FNV66_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS04780	COG2188	Transcriptional regulator
FNV66_RS04785	COG2182	Extracellular solute-binding protein
FNV66_RS04790	COG1175	transmembrane transport
FNV66_RS04795	COG0395	ABC-type sugar transport system, permease component
FNV66_RS04865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV66_RS04875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FNV66_RS04915	COG3469	chitinase activity
FNV66_RS04930	COG3629	intracellular signal transduction
FNV66_RS04930	COG3903	Transcriptional regulator
FNV66_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS04990	COG1764	response to oxidative stress
FNV66_RS05055	COG2208	phosphoserine phosphatase activity
FNV66_RS05055	COG2770	Histidine kinase
FNV66_RS05075	COG0583	DNA-binding transcription factor activity
FNV66_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS05115	COG0702	epimerase
FNV66_RS05125	COG2271	Major facilitator Superfamily
FNV66_RS05130	COG2755	lipolytic protein G-D-S-L family
FNV66_RS05130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FNV66_RS05135	COG3250	beta-galactosidase activity
FNV66_RS05175	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FNV66_RS05210	COG2197	response regulator
FNV66_RS05225	COG1082	Xylose isomerase domain protein TIM barrel
FNV66_RS05235	COG1082	Xylose isomerase domain protein TIM barrel
FNV66_RS05255	COG2226	methyltransferase
FNV66_RS05260	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FNV66_RS05275	COG0477	Major facilitator Superfamily
FNV66_RS05290	COG4213	ABC transporter substrate-binding protein
FNV66_RS05300	COG4213	ABC transporter substrate-binding protein
FNV66_RS05310	COG4214	carbohydrate transport
FNV66_RS05320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV66_RS05325	COG1414	Transcriptional regulator
FNV66_RS05350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FNV66_RS05355	COG0640	Transcriptional regulator
FNV66_RS05360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV66_RS05365	COG0248	Ppx GppA phosphatase
FNV66_RS05395	COG0395	ABC-type sugar transport system, permease component
FNV66_RS05410	COG0477	Major facilitator Superfamily
FNV66_RS05420	COG2124	cytochrome p450
FNV66_RS05495	COG1191	sigma factor activity
FNV66_RS05500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FNV66_RS05575	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FNV66_RS05585	COG1064	alcohol dehydrogenase
FNV66_RS05615	COG0009	L-threonylcarbamoyladenylate synthase
FNV66_RS05625	COG0443	Heat shock 70 kDa protein
FNV66_RS05630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FNV66_RS05645	COG0542	response to heat
FNV66_RS05660	COG1414	Transcriptional regulator
FNV66_RS05665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV66_RS05670	COG2610	gluconate transmembrane transporter activity
FNV66_RS05675	COG4948	Mandelate Racemase Muconate Lactonizing
FNV66_RS05690	COG1136	(ABC) transporter
FNV66_RS05695	COG4585	Histidine kinase
FNV66_RS05700	COG2197	response regulator
FNV66_RS05705	COG1309	transcriptional regulator
FNV66_RS05710	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS05720	COG1595	DNA-templated transcription, initiation
FNV66_RS05775	COG2814	Major facilitator Superfamily
FNV66_RS05790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FNV66_RS05795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV66_RS05800	COG2186	Transcriptional regulator
FNV66_RS05820	COG5006	permease, DMT superfamily
FNV66_RS05835	COG0477	Major facilitator Superfamily
FNV66_RS05890	COG0464	growth
FNV66_RS06000	COG1846	Transcriptional regulator
FNV66_RS06000	COG1940	carbohydrate kinase activity
FNV66_RS06080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FNV66_RS06100	COG4585	Histidine kinase
FNV66_RS06105	COG2197	response regulator
FNV66_RS06160	COG1881	PFAM PEBP family protein
FNV66_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS06180	COG2186	Transcriptional regulator
FNV66_RS06185	COG1024	Enoyl-CoA hydratase
FNV66_RS06190	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS06195	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS06200	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS06205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV66_RS06210	COG1024	Enoyl-CoA hydratase
FNV66_RS06215	COG0183	Belongs to the thiolase family
FNV66_RS06220	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS06225	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS06240	COG1024	Enoyl-CoA hydratase
FNV66_RS06245	COG1024	Enoyl-CoA hydratase
FNV66_RS06295	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS06305	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS06310	COG2272	Belongs to the type-B carboxylesterase lipase family
FNV66_RS06315	COG1024	Enoyl-CoA hydratase
FNV66_RS06330	COG0183	Belongs to the thiolase family
FNV66_RS06335	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS06355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS06360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS06365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS06365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS06370	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS06380	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS06390	COG1024	Enoyl-CoA hydratase
FNV66_RS06400	COG1309	transcriptional regulator
FNV66_RS06440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV66_RS06445	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS06470	COG4638	Rieske (2fe-2S)
FNV66_RS06480	COG1228	amidohydrolase
FNV66_RS06490	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS06500	COG0604	alcohol dehydrogenase
FNV66_RS06500	COG3321	synthase
FNV66_RS06510	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS06550	COG1846	Transcriptional regulator
FNV66_RS06555	COG1309	transcriptional regulator
FNV66_RS06560	COG4585	Histidine kinase
FNV66_RS06565	COG2197	response regulator
FNV66_RS06585	COG2814	Major facilitator Superfamily
FNV66_RS06635	COG0277	FAD linked oxidase domain protein
FNV66_RS06650	COG0366	Alpha amylase catalytic
FNV66_RS06660	COG3281	Trehalose synthase
FNV66_RS06665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FNV66_RS06695	COG0577	efflux transmembrane transporter activity
FNV66_RS06695	COG1136	(ABC) transporter
FNV66_RS06755	COG0477	Major facilitator Superfamily
FNV66_RS06775	COG0494	nUDIX hydrolase
FNV66_RS06900	COG2815	serine threonine protein kinase
FNV66_RS06900	COG0515	serine threonine protein kinase
FNV66_RS06915	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FNV66_RS06930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FNV66_RS06945	COG1902	pentaerythritol trinitrate reductase activity
FNV66_RS06955	COG1216	Glycosyl transferase, family 2
FNV66_RS06955	COG1442	glycosyl transferase family 8
FNV66_RS07010	COG0475	glutathione-regulated potassium exporter activity
FNV66_RS07020	COG2124	cytochrome p450
FNV66_RS07195	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV66_RS07200	COG1793	dna ligase
FNV66_RS07240	COG3903	Transcriptional regulator
FNV66_RS07240	COG3629	intracellular signal transduction
FNV66_RS07305	COG1278	Cold shock
FNV66_RS07350	COG3344	reverse transcriptase
FNV66_RS07370	COG1484	DNA-dependent DNA replication
FNV66_RS07375	COG4584	PFAM Integrase catalytic
FNV66_RS07440	COG3345	alpha-galactosidase
FNV66_RS07445	COG0395	ABC-type sugar transport system, permease component
FNV66_RS07450	COG1175	transmembrane transport
FNV66_RS07460	COG1940	carbohydrate kinase activity
FNV66_RS07460	COG1846	Transcriptional regulator
FNV66_RS07475	COG3848	Pyruvate phosphate dikinase
FNV66_RS07475	COG0574	Belongs to the PEP-utilizing enzyme family
FNV66_RS07530	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV66_RS07535	COG1793	dna ligase
FNV66_RS07545	COG0539	negative regulation of cytoplasmic translation
FNV66_RS07570	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS07595	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FNV66_RS07645	COG2267	carboxylic ester hydrolase activity
FNV66_RS07725	COG2226	methyltransferase
FNV66_RS07895	COG3547	Transposase (IS116 IS110 IS902 family)
FNV66_RS08065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FNV66_RS08070	COG1793	dna ligase
FNV66_RS08070	COG3285	dna ligase
FNV66_RS08120	COG2826	transposase and inactivated derivatives, IS30 family
FNV66_RS08160	COG2801	Transposase and inactivated derivatives
FNV66_RS08195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FNV66_RS08260	COG3387	PFAM Glycoside hydrolase 15-related
FNV66_RS08285	COG0492	ferredoxin-NADP+ reductase activity
FNV66_RS08305	COG2409	Drug exporters of the RND superfamily
FNV66_RS08320	COG2197	response regulator
FNV66_RS08360	COG3655	Transcriptional regulator
FNV66_RS08425	COG1335	isochorismatase
FNV66_RS08435	COG3328	transposase activity
FNV66_RS08515	COG0832	Belongs to the urease beta subunit family
FNV66_RS08515	COG0831	urea catabolic process
FNV66_RS08520	COG0804	urea catabolic process
FNV66_RS08525	COG0830	nickel cation binding
FNV66_RS08530	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FNV66_RS08535	COG0829	nickel cation binding
FNV66_RS08545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FNV66_RS08570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV66_RS08620	COG1215	transferase activity, transferring glycosyl groups
FNV66_RS08635	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS08640	COG0789	Transcriptional regulator
FNV66_RS08645	COG4221	oxidoreductase activity
FNV66_RS08660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FNV66_RS08710	COG1618	nucleotide phosphatase activity, acting on free nucleotides
FNV66_RS08785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV66_RS08820	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FNV66_RS08870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FNV66_RS08970	COG2304	oxidoreductase activity
FNV66_RS09000	COG0328	RNA-DNA hybrid ribonuclease activity
FNV66_RS09040	COG3226	Transcriptional regulator
FNV66_RS09065	COG0747	negative chemotaxis
FNV66_RS09095	COG3835	regulator
FNV66_RS09100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV66_RS09100	COG2010	Cytochrome c
FNV66_RS09105	COG2080	2 iron, 2 sulfur cluster binding
FNV66_RS09125	COG0009	L-threonylcarbamoyladenylate synthase
FNV66_RS09230	COG0596	Alpha beta hydrolase
FNV66_RS09235	COG0740	serine-type endopeptidase activity
FNV66_RS09240	COG0740	serine-type endopeptidase activity
FNV66_RS09250	COG2318	DinB family
FNV66_RS09265	COG0784	Response regulator, receiver
FNV66_RS09270	COG4251	negative regulation of phosphorylation
FNV66_RS09335	COG0842	Transport permease protein
FNV66_RS09335	COG1131	(ABC) transporter
FNV66_RS09335	COG1716	ATPase activity
FNV66_RS09350	COG2207	Transcriptional regulator
FNV66_RS09360	COG0667	Aldo Keto reductase
FNV66_RS09365	COG0583	DNA-binding transcription factor activity
FNV66_RS09380	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV66_RS09385	COG0346	lactoylglutathione lyase activity
FNV66_RS09390	COG0671	phosphoesterase, PA-phosphatase related
FNV66_RS09400	COG0412	Dienelactone hydrolase
FNV66_RS09405	COG0667	Aldo Keto reductase
FNV66_RS09415	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS09420	COG4941	Belongs to the sigma-70 factor family
FNV66_RS09435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS09445	COG0431	NADPH-dependent FMN reductase
FNV66_RS09465	COG0702	epimerase
FNV66_RS09550	COG0531	amino acid
FNV66_RS09555	COG1940	carbohydrate kinase activity
FNV66_RS09560	COG3250	beta-galactosidase activity
FNV66_RS09580	COG3345	alpha-galactosidase
FNV66_RS09585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV66_RS09605	COG0667	Aldo Keto reductase
FNV66_RS09635	COG0367	asparagine synthase
FNV66_RS09640	COG0069	glutamate synthase activity
FNV66_RS09645	COG2235	arginine
FNV66_RS09660	COG0673	inositol 2-dehydrogenase activity
FNV66_RS09665	COG3511	phospholipase C
FNV66_RS09715	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FNV66_RS09715	COG1672	PFAM Archaeal ATPase
FNV66_RS09755	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS09760	COG2366	antibiotic biosynthetic process
FNV66_RS09770	COG2070	2-Nitropropane dioxygenase
FNV66_RS09780	COG0515	serine threonine protein kinase
FNV66_RS09790	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS09815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FNV66_RS09820	COG4171	peptide transport system, permease
FNV66_RS09830	COG0747	negative chemotaxis
FNV66_RS09845	COG0019	diaminopimelate decarboxylase activity
FNV66_RS09850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FNV66_RS09855	COG0534	Mate efflux family protein
FNV66_RS09860	COG1609	Transcriptional regulator
FNV66_RS09875	COG2188	Transcriptional regulator
FNV66_RS09885	COG3962	Belongs to the TPP enzyme family
FNV66_RS09890	COG3718	enzyme involved in inositol metabolism
FNV66_RS09900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV66_RS09930	COG0028	Belongs to the TPP enzyme family
FNV66_RS09935	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS09940	COG2072	flavoprotein involved in K transport
FNV66_RS09945	COG4638	Rieske (2fe-2S)
FNV66_RS09950	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS09955	COG3386	PFAM SMP-30 Gluconolaconase
FNV66_RS09960	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS09965	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS09975	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS09980	COG0604	alcohol dehydrogenase
FNV66_RS09990	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS09995	COG0427	acetyl-CoA hydrolase
FNV66_RS10015	COG2186	Transcriptional regulator
FNV66_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS10030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV66_RS10035	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS10055	COG1063	alcohol dehydrogenase
FNV66_RS10065	COG1335	isochorismatase
FNV66_RS10135	COG2072	flavoprotein involved in K transport
FNV66_RS10160	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FNV66_RS10165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FNV66_RS10170	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FNV66_RS10180	COG0531	amino acid
FNV66_RS10230	COG3321	synthase
FNV66_RS10230	COG0604	alcohol dehydrogenase
FNV66_RS10240	COG1073	alpha beta
FNV66_RS10280	COG0363	glucosamine-6-phosphate deaminase activity
FNV66_RS10285	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FNV66_RS10300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FNV66_RS10305	COG2376	Dihydroxyacetone kinase
FNV66_RS10310	COG1461	Dihydroxyacetone kinase
FNV66_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS10355	COG1902	pentaerythritol trinitrate reductase activity
FNV66_RS10355	COG0446	pyridine nucleotide-disulphide oxidoreductase
FNV66_RS10360	COG2890	protein-(glutamine-N5) methyltransferase activity
FNV66_RS10380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FNV66_RS10405	COG3458	cephalosporin-C deacetylase activity
FNV66_RS10420	COG2188	Transcriptional regulator
FNV66_RS10430	COG2226	methyltransferase
FNV66_RS10435	COG0366	Alpha amylase catalytic
FNV66_RS10440	COG2267	carboxylic ester hydrolase activity
FNV66_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS10455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FNV66_RS10495	COG0179	Fumarylacetoacetate (FAA) hydrolase
FNV66_RS10510	COG4941	Belongs to the sigma-70 factor family
FNV66_RS10520	COG3795	YCII-related domain
FNV66_RS10530	COG0346	lactoylglutathione lyase activity
FNV66_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS10545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FNV66_RS10550	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FNV66_RS10555	COG1686	Belongs to the peptidase S11 family
FNV66_RS10565	COG2066	Belongs to the glutaminase family
FNV66_RS10580	COG1113	amino acid transport
FNV66_RS10590	COG1968	undecaprenyl-diphosphatase activity
FNV66_RS10595	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FNV66_RS10600	COG1993	acr, cog1993
FNV66_RS10605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FNV66_RS10630	COG1175	transmembrane transport
FNV66_RS10635	COG0395	ABC-type sugar transport system, permease component
FNV66_RS10655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FNV66_RS10670	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS10680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV66_RS10720	COG1215	transferase activity, transferring glycosyl groups
FNV66_RS10735	COG0633	Ferredoxin
FNV66_RS10735	COG3217	Mosc domain protein beta barrel domain protein
FNV66_RS10755	COG1349	DNA-binding transcription factor activity
FNV66_RS10780	COG0577	efflux transmembrane transporter activity
FNV66_RS10785	COG1136	(ABC) transporter
FNV66_RS10810	COG1940	carbohydrate kinase activity
FNV66_RS10820	COG2813	Specifically methylates the guanine in position
FNV66_RS10845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FNV66_RS10850	COG1349	DNA-binding transcription factor activity
FNV66_RS10855	COG3537	Alpha-1,2-mannosidase
FNV66_RS10865	COG1174	glycine betaine transport
FNV66_RS10885	COG2018	Roadblock/LC7 domain
FNV66_RS10915	COG3320	Male sterility
FNV66_RS10915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV66_RS10925	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS10935	COG0596	Alpha beta hydrolase
FNV66_RS10940	COG4565	transcriptional regulatory protein
FNV66_RS10945	COG3290	protein histidine kinase activity
FNV66_RS10955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV66_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS10990	COG1271	oxidase subunit
FNV66_RS11045	COG3387	PFAM Glycoside hydrolase 15-related
FNV66_RS11065	COG2223	nitrite transmembrane transporter activity
FNV66_RS11090	COG2197	response regulator
FNV66_RS11095	COG4585	Histidine kinase
FNV66_RS11110	COG0445	tRNA wobble uridine modification
FNV66_RS11115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV66_RS11120	COG1660	Displays ATPase and GTPase activities
FNV66_RS11150	COG0395	ABC-type sugar transport system, permease component
FNV66_RS11165	COG3345	alpha-galactosidase
FNV66_RS11195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FNV66_RS11220	COG0204	Acyl-transferase
FNV66_RS11245	COG0584	glycerophosphoryl diester phosphodiesterase
FNV66_RS11305	COG1309	transcriptional regulator
FNV66_RS11330	COG0640	Transcriptional regulator
FNV66_RS11335	COG1902	pentaerythritol trinitrate reductase activity
FNV66_RS11350	COG2197	response regulator
FNV66_RS11355	COG4585	Histidine kinase
FNV66_RS11360	COG3963	phosphatidate phosphatase activity
FNV66_RS11380	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FNV66_RS11380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FNV66_RS11430	COG0714	Associated with various cellular activities
FNV66_RS11435	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FNV66_RS11465	COG0596	Alpha beta hydrolase
FNV66_RS11470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FNV66_RS11470	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FNV66_RS11475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FNV66_RS11485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FNV66_RS11500	COG2706	6-phosphogluconolactonase activity
FNV66_RS11505	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
FNV66_RS11540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV66_RS11545	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FNV66_RS11550	COG2080	2 iron, 2 sulfur cluster binding
FNV66_RS11565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FNV66_RS11580	COG2770	Histidine kinase
FNV66_RS11580	COG2208	phosphoserine phosphatase activity
FNV66_RS11600	COG0745	RESPONSE REGULATOR receiver
FNV66_RS11635	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS11690	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS11720	COG0667	Aldo Keto reductase
FNV66_RS11725	COG4221	oxidoreductase activity
FNV66_RS11745	COG0513	Belongs to the DEAD box helicase family
FNV66_RS11755	COG0432	Pfam Uncharacterised protein family UPF0047
FNV66_RS11760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV66_RS11765	COG1116	anion transmembrane transporter activity
FNV66_RS11775	COG2072	flavoprotein involved in K transport
FNV66_RS11785	COG1132	(ABC) transporter
FNV66_RS11795	COG1301	dicarboxylic acid transport
FNV66_RS11815	COG1132	(ABC) transporter
FNV66_RS11825	COG0254	rRNA binding
FNV66_RS11840	COG1946	Acyl-CoA thioesterase
FNV66_RS11850	COG2018	Roadblock/LC7 domain
FNV66_RS11915	COG3239	Fatty acid desaturase
FNV66_RS11920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FNV66_RS11940	COG2115	Belongs to the xylose isomerase family
FNV66_RS11950	COG1846	Transcriptional regulator
FNV66_RS11950	COG1940	carbohydrate kinase activity
FNV66_RS11975	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS12020	COG0515	serine threonine protein kinase
FNV66_RS12045	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS12050	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS12065	COG0492	ferredoxin-NADP+ reductase activity
FNV66_RS12070	COG1793	dna ligase
FNV66_RS12080	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS12095	COG3424	synthase
FNV66_RS12100	COG2124	cytochrome p450
FNV66_RS12120	COG0242	peptide deformylase activity
FNV66_RS12130	COG3442	glutamine amidotransferase
FNV66_RS12135	COG0205	6-phosphofructokinase activity
FNV66_RS12160	COG3275	phosphorelay sensor kinase activity
FNV66_RS12165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV66_RS12175	COG3279	Response regulator of the LytR AlgR family
FNV66_RS12185	COG1834	amidinotransferase
FNV66_RS12190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FNV66_RS12200	COG1510	regulation of RNA biosynthetic process
FNV66_RS12210	COG1733	regulation of RNA biosynthetic process
FNV66_RS12235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FNV66_RS12260	COG0829	nickel cation binding
FNV66_RS12265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FNV66_RS12275	COG0804	urea catabolic process
FNV66_RS12280	COG0832	Belongs to the urease beta subunit family
FNV66_RS12285	COG0831	urea catabolic process
FNV66_RS12295	COG0740	serine-type endopeptidase activity
FNV66_RS12335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FNV66_RS12340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FNV66_RS12345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FNV66_RS12355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FNV66_RS12360	COG2226	methyltransferase
FNV66_RS12430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FNV66_RS12440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FNV66_RS12445	COG3663	DNA glycosylase
FNV66_RS12465	COG4585	Histidine kinase
FNV66_RS12470	COG2197	response regulator
FNV66_RS12475	COG1940	carbohydrate kinase activity
FNV66_RS12480	COG2188	Transcriptional regulator
FNV66_RS12485	COG1595	DNA-templated transcription, initiation
FNV66_RS12500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV66_RS12515	COG0626	cystathionine gamma-synthase activity
FNV66_RS12535	COG0583	DNA-binding transcription factor activity
FNV66_RS12545	COG1522	sequence-specific DNA binding
FNV66_RS12550	COG0419	ATPase involved in DNA repair
FNV66_RS12555	COG0420	3'-5' exonuclease activity
FNV66_RS12560	COG1739	Uncharacterized protein family UPF0029
FNV66_RS12580	COG2197	response regulator
FNV66_RS12590	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS12605	COG1832	CoA-binding protein
FNV66_RS12615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FNV66_RS12620	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FNV66_RS12640	COG2326	polyphosphate kinase activity
FNV66_RS12670	COG0110	maltose O-acetyltransferase activity
FNV66_RS12690	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV66_RS12705	COG1609	Transcriptional regulator
FNV66_RS12740	COG0076	glutamate decarboxylase activity
FNV66_RS12755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FNV66_RS12770	COG0183	Belongs to the thiolase family
FNV66_RS12795	COG1968	undecaprenyl-diphosphatase activity
FNV66_RS12820	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS12835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS12845	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FNV66_RS12855	COG2318	DinB family
FNV66_RS12870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FNV66_RS12875	COG0747	negative chemotaxis
FNV66_RS12915	COG1760	l-serine dehydratase
FNV66_RS12920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FNV66_RS12925	COG0509	glycine decarboxylation via glycine cleavage system
FNV66_RS12960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FNV66_RS12980	COG4175	Glycine betaine
FNV66_RS12980	COG0517	IMP dehydrogenase activity
FNV66_RS12985	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS13000	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FNV66_RS13010	COG4638	Rieske (2fe-2S)
FNV66_RS13015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FNV66_RS13025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV66_RS13065	COG0697	spore germination
FNV66_RS13135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FNV66_RS13135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FNV66_RS13145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FNV66_RS13165	COG1716	ATPase activity
FNV66_RS13185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FNV66_RS13215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FNV66_RS13230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV66_RS13235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV66_RS13245	COG2816	NAD+ diphosphatase activity
FNV66_RS13250	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FNV66_RS13260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV66_RS13265	COG3706	GGDEF domain
FNV66_RS13270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FNV66_RS13275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV66_RS13295	COG2018	Roadblock/LC7 domain
FNV66_RS13335	COG2814	Major facilitator Superfamily
FNV66_RS13340	COG4336	lyase activity
FNV66_RS13345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FNV66_RS13350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FNV66_RS13355	COG1984	allophanate hydrolase subunit 2
FNV66_RS13360	COG2755	lipolytic protein G-D-S-L family
FNV66_RS13365	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS13370	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS13395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV66_RS13410	COG2270	Major facilitator Superfamily
FNV66_RS13425	COG0463	Glycosyl transferase, family 2
FNV66_RS13460	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS13470	COG1309	transcriptional regulator
FNV66_RS13515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FNV66_RS13520	COG0140	phosphoribosyl-ATP diphosphatase activity
FNV66_RS13525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FNV66_RS13530	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FNV66_RS13530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FNV66_RS13535	COG3201	nicotinamide mononucleotide transporter
FNV66_RS13545	COG1940	carbohydrate kinase activity
FNV66_RS13545	COG1846	Transcriptional regulator
FNV66_RS13550	COG2223	nitrite transmembrane transporter activity
FNV66_RS13565	COG2233	PERMEase
FNV66_RS13590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FNV66_RS13610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FNV66_RS13615	COG3842	ATPase activity
FNV66_RS13625	COG1176	ABC-type spermidine putrescine transport system, permease component I
FNV66_RS13635	COG2188	Transcriptional regulator
FNV66_RS13645	COG0531	amino acid
FNV66_RS13665	COG2390	Transcriptional regulator
FNV66_RS13670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FNV66_RS13680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FNV66_RS13700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FNV66_RS13715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FNV66_RS13730	COG0194	GDP metabolic process
FNV66_RS13740	COG0284	orotidine-5'-phosphate decarboxylase activity
FNV66_RS13745	COG0167	dihydroorotate dehydrogenase activity
FNV66_RS13750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FNV66_RS13755	COG0505	Belongs to the CarA family
FNV66_RS13765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FNV66_RS13770	COG0540	Belongs to the ATCase OTCase family
FNV66_RS13775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FNV66_RS13785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FNV66_RS13790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FNV66_RS13795	COG0006	proline dipeptidase activity
FNV66_RS13805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FNV66_RS13810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FNV66_RS13815	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FNV66_RS13820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FNV66_RS13825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FNV66_RS13830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FNV66_RS13835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FNV66_RS13855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FNV66_RS13870	COG1131	(ABC) transporter
FNV66_RS13880	COG4585	Histidine kinase
FNV66_RS13885	COG2197	response regulator
FNV66_RS13890	COG0124	histidyl-tRNA synthetase
FNV66_RS13900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FNV66_RS13905	COG1196	nuclear chromosome segregation
FNV66_RS13910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FNV66_RS13915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FNV66_RS13920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FNV66_RS13925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FNV66_RS13935	COG2255	four-way junction helicase activity
FNV66_RS13940	COG0632	four-way junction helicase activity
FNV66_RS13945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FNV66_RS13950	COG0217	transcriptional regulatory protein
FNV66_RS13955	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FNV66_RS13960	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FNV66_RS13975	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS13985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FNV66_RS14005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FNV66_RS14010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FNV66_RS14025	COG2176	DNA-directed DNA polymerase activity
FNV66_RS14025	COG5002	protein histidine kinase activity
FNV66_RS14055	COG0395	ABC-type sugar transport system, permease component
FNV66_RS14060	COG1175	transmembrane transport
FNV66_RS14115	COG0512	Glutamine amidotransferase of anthranilate synthase
FNV66_RS14115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FNV66_RS14175	COG1648	precorrin-2 dehydrogenase activity
FNV66_RS14175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FNV66_RS14180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FNV66_RS14195	COG1464	Belongs to the NlpA lipoprotein family
FNV66_RS14200	COG2011	ABC-type metal ion transport system permease component
FNV66_RS14205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FNV66_RS14240	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS14240	COG0204	Acyl-transferase
FNV66_RS14245	COG0477	Major facilitator Superfamily
FNV66_RS14260	COG0165	Argininosuccinate lyase
FNV66_RS14265	COG0137	argininosuccinate synthase activity
FNV66_RS14285	COG2205	protein histidine kinase activity
FNV66_RS14290	COG0745	RESPONSE REGULATOR receiver
FNV66_RS14320	COG1438	arginine binding
FNV66_RS14325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FNV66_RS14330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FNV66_RS14335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FNV66_RS14340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FNV66_RS14360	COG0789	Transcriptional regulator
FNV66_RS14390	COG0697	spore germination
FNV66_RS14400	COG1649	PFAM Uncharacterised BCR, COG1649
FNV66_RS14430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNV66_RS14430	COG0072	phenylalanine-tRNA ligase activity
FNV66_RS14435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FNV66_RS14440	COG5002	protein histidine kinase activity
FNV66_RS14445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FNV66_RS14450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FNV66_RS14455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FNV66_RS14460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FNV66_RS14515	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS14520	COG0174	glutamine synthetase
FNV66_RS14530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FNV66_RS14570	COG4176	ABC-type proline glycine betaine transport system permease component
FNV66_RS14575	COG4175	Glycine betaine
FNV66_RS14575	COG0517	IMP dehydrogenase activity
FNV66_RS14580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNV66_RS14825	COG0564	pseudouridine synthase activity
FNV66_RS14855	COG1309	transcriptional regulator
FNV66_RS14895	COG0805	protein transport
FNV66_RS14900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FNV66_RS14930	COG0545	Peptidyl-prolyl cis-trans isomerase
FNV66_RS14935	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FNV66_RS14945	COG1609	Transcriptional regulator
FNV66_RS14950	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FNV66_RS14955	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FNV66_RS14970	COG4122	O-methyltransferase activity
FNV66_RS14975	COG1222	aaa ATPase
FNV66_RS14995	COG1994	Peptidase M50
FNV66_RS14995	COG0517	IMP dehydrogenase activity
FNV66_RS15005	COG2197	response regulator
FNV66_RS15015	COG4166	transmembrane transport
FNV66_RS15025	COG0646	methionine synthase
FNV66_RS15025	COG1410	methionine synthase
FNV66_RS15030	COG1414	Transcriptional regulator
FNV66_RS15035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FNV66_RS15040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV66_RS15045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FNV66_RS15050	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
FNV66_RS15060	COG1129	ABC transporter
FNV66_RS15070	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FNV66_RS15075	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FNV66_RS15080	COG0235	Class ii aldolase
FNV66_RS15085	COG0235	Class ii aldolase
FNV66_RS15085	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FNV66_RS15090	COG2186	Transcriptional regulator
FNV66_RS15115	COG0215	cysteine-tRNA ligase activity
FNV66_RS15135	COG0598	Magnesium transport protein CorA
FNV66_RS15145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS15150	COG0667	Aldo Keto reductase
FNV66_RS15180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV66_RS15195	COG0308	aminopeptidase N
FNV66_RS15200	COG3012	SEC-C Motif Domain Protein
FNV66_RS15205	COG2186	Transcriptional regulator
FNV66_RS15210	COG3265	gluconokinase activity
FNV66_RS15220	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS15225	COG1063	alcohol dehydrogenase
FNV66_RS15250	COG3573	Dehydrogenase
FNV66_RS15260	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FNV66_RS15265	COG2149	membrane
FNV66_RS15295	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS15305	COG3876	Protein conserved in bacteria
FNV66_RS15325	COG0072	phenylalanine-tRNA ligase activity
FNV66_RS15325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNV66_RS15330	COG0789	Transcriptional regulator
FNV66_RS15350	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS15360	COG0640	Transcriptional regulator
FNV66_RS15365	COG0697	spore germination
FNV66_RS15390	COG2851	Citrate transporter
FNV66_RS15395	COG0243	molybdopterin cofactor binding
FNV66_RS15400	COG1309	transcriptional regulator
FNV66_RS15410	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FNV66_RS15415	COG2188	Transcriptional regulator
FNV66_RS15450	COG1595	DNA-templated transcription, initiation
FNV66_RS15470	COG0515	serine threonine protein kinase
FNV66_RS15470	COG2815	serine threonine protein kinase
FNV66_RS15475	COG2755	lipolytic protein G-D-S-L family
FNV66_RS15500	COG1649	PFAM Uncharacterised BCR, COG1649
FNV66_RS15500	COG0726	polysaccharide deacetylase
FNV66_RS15525	COG1725	Transcriptional regulator
FNV66_RS15565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FNV66_RS15565	COG0662	Cupin 2, conserved barrel domain protein
FNV66_RS15570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FNV66_RS15575	COG0587	DNA-directed DNA polymerase activity
FNV66_RS15585	COG0330	HflC and HflK could
FNV66_RS15600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS15605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS15610	COG1126	abc transporter atp-binding protein
FNV66_RS15620	COG0765	amino acid transport
FNV66_RS15635	COG1799	cell septum assembly
FNV66_RS15640	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS15645	COG0477	Major facilitator Superfamily
FNV66_RS15655	COG0671	phosphoesterase, PA-phosphatase related
FNV66_RS15665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FNV66_RS15695	COG1129	ABC transporter
FNV66_RS15725	COG1160	GTP binding
FNV66_RS15735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FNV66_RS15775	COG3541	Predicted nucleotidyltransferase
FNV66_RS15790	COG1187	pseudouridine synthase activity
FNV66_RS15795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FNV66_RS15800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FNV66_RS15815	COG0686	Belongs to the AlaDH PNT family
FNV66_RS15825	COG0494	nUDIX hydrolase
FNV66_RS15830	COG0504	CTP synthase activity
FNV66_RS15835	COG3387	PFAM Glycoside hydrolase 15-related
FNV66_RS15860	COG0497	DNA recombination
FNV66_RS15865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FNV66_RS15885	COG1120	ATPase activity
FNV66_RS15890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV66_RS15895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV66_RS15900	COG0647	UMP catabolic process
FNV66_RS15935	COG2094	Belongs to the DNA glycosylase MPG family
FNV66_RS15945	COG1881	PFAM PEBP family protein
FNV66_RS15965	COG1119	ATPase activity
FNV66_RS15980	COG2197	response regulator
FNV66_RS15990	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS15995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FNV66_RS16005	COG1716	ATPase activity
FNV66_RS16005	COG0842	Transport permease protein
FNV66_RS16005	COG1131	(ABC) transporter
FNV66_RS16015	COG0560	Phosphoserine phosphatase
FNV66_RS16015	COG3830	Belongs to the UPF0237 family
FNV66_RS16020	COG0588	phosphoglycerate mutase activity
FNV66_RS16035	COG2186	Transcriptional regulator
FNV66_RS16045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FNV66_RS16050	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS16065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FNV66_RS16085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FNV66_RS16090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV66_RS16110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV66_RS16160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FNV66_RS16175	COG3387	PFAM Glycoside hydrolase 15-related
FNV66_RS16225	COG0488	(ABC) transporter
FNV66_RS16255	COG0235	Class ii aldolase
FNV66_RS16275	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FNV66_RS16280	COG1492	cobalamin metabolic process
FNV66_RS16295	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FNV66_RS16300	COG1797	cobyrinic acid a,c-diamide synthase activity
FNV66_RS16360	COG0765	amino acid transport
FNV66_RS16365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV66_RS16370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FNV66_RS16375	COG0456	acetyltransferase
FNV66_RS16380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FNV66_RS16385	COG1917	Cupin 2, conserved barrel domain protein
FNV66_RS16390	COG5285	phytanoyl-CoA dioxygenase
FNV66_RS16395	COG3844	kynureninase activity
FNV66_RS16420	COG1414	Transcriptional regulator
FNV66_RS16430	COG0768	penicillin binding
FNV66_RS16435	COG2252	PERMEase
FNV66_RS16440	COG1595	DNA-templated transcription, initiation
FNV66_RS16455	COG4733	cellulase activity
FNV66_RS16495	COG4677	pectinesterase activity
FNV66_RS16500	COG3866	Pectate lyase
FNV66_RS16505	COG2755	lipolytic protein G-D-S-L family
FNV66_RS16510	COG1653	transport
FNV66_RS16530	COG0395	ABC-type sugar transport system, permease component
FNV66_RS16545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV66_RS16550	COG1802	Transcriptional regulator
FNV66_RS16575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FNV66_RS16580	COG1349	DNA-binding transcription factor activity
FNV66_RS16595	COG0395	ABC-type sugar transport system, permease component
FNV66_RS16600	COG1063	alcohol dehydrogenase
FNV66_RS16610	COG1309	transcriptional regulator
FNV66_RS16625	COG1802	Transcriptional regulator
FNV66_RS16670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV66_RS16675	COG3973	AAA domain
FNV66_RS16690	COG2171	N-acyltransferase activity
FNV66_RS16695	COG3226	Transcriptional regulator
FNV66_RS16700	COG2076	Multidrug Resistance protein
FNV66_RS16715	COG2151	metal-sulfur cluster biosynthetic enzyme
FNV66_RS16720	COG0822	iron-sulfur transferase activity
FNV66_RS16725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FNV66_RS16730	COG0396	ATPase activity
FNV66_RS16740	COG0719	Fe-S assembly protein
FNV66_RS16755	COG2746	aminoglycoside 3-N-acetyltransferase activity
FNV66_RS16760	COG1131	(ABC) transporter
FNV66_RS16785	COG0109	protoheme IX farnesyltransferase activity
FNV66_RS16795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FNV66_RS16810	COG0363	glucosamine-6-phosphate deaminase activity
FNV66_RS16815	COG0395	ABC-type sugar transport system, permease component
FNV66_RS16820	COG1175	transmembrane transport
FNV66_RS16830	COG0366	Alpha amylase catalytic
FNV66_RS16835	COG1653	transport
FNV66_RS16840	COG1695	Transcriptional regulator
FNV66_RS16845	COG1136	(ABC) transporter
FNV66_RS16860	COG0166	Belongs to the GPI family
FNV66_RS16875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FNV66_RS16880	COG0149	triose-phosphate isomerase activity
FNV66_RS16885	COG0126	phosphoglycerate kinase activity
FNV66_RS16890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FNV66_RS16900	COG1481	regulation of sporulation
FNV66_RS16905	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FNV66_RS16910	COG1660	Displays ATPase and GTPase activities
FNV66_RS16915	COG0322	excinuclease ABC activity
FNV66_RS16930	COG1609	Transcriptional regulator
FNV66_RS16940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FNV66_RS16955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV66_RS16960	COG0765	amino acid transport
FNV66_RS16970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FNV66_RS16975	COG0477	Major facilitator Superfamily
FNV66_RS16980	COG0387	Pfam Sodium calcium exchanger
FNV66_RS17000	COG0556	nucleotide-excision repair
FNV66_RS17010	COG0584	glycerophosphoryl diester phosphodiesterase
FNV66_RS17015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FNV66_RS17035	COG2313	pseudouridylate synthase activity
FNV66_RS17045	COG2226	methyltransferase
FNV66_RS17050	COG0598	Magnesium transport protein CorA
FNV66_RS17080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS17090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV66_RS17135	COG0402	S-adenosylhomocysteine deaminase activity
FNV66_RS17165	COG1953	Uracil, thiamine, allantoin
FNV66_RS17170	COG1802	Transcriptional regulator
FNV66_RS17175	COG2267	carboxylic ester hydrolase activity
FNV66_RS17185	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FNV66_RS17215	COG0237	dephospho-CoA kinase activity
FNV66_RS17235	COG2226	methyltransferase
FNV66_RS17240	COG1643	Atp-dependent helicase
FNV66_RS17280	COG2050	protein possibly involved in aromatic compounds catabolism
FNV66_RS17340	COG0737	Belongs to the 5'-nucleotidase family
FNV66_RS17360	COG4566	intracellular signal transduction
FNV66_RS17365	COG0287	Prephenate dehydrogenase
FNV66_RS17365	COG1605	Chorismate mutase
FNV66_RS17395	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS17400	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS17405	COG1024	Enoyl-CoA hydratase
FNV66_RS17430	COG0183	Belongs to the thiolase family
FNV66_RS17435	COG1309	transcriptional regulator
FNV66_RS17445	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS17450	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS17455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FNV66_RS17465	COG2304	oxidoreductase activity
FNV66_RS17480	COG1136	(ABC) transporter
FNV66_RS17480	COG4591	ABC-type transport system involved in lipoprotein release permease component
FNV66_RS17495	COG1136	(ABC) transporter
FNV66_RS17495	COG0577	efflux transmembrane transporter activity
FNV66_RS17505	COG0070	glutamate synthase
FNV66_RS17505	COG0067	glutamate synthase
FNV66_RS17505	COG0069	glutamate synthase activity
FNV66_RS17535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV66_RS17540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV66_RS17545	COG2301	Belongs to the HpcH HpaI aldolase family
FNV66_RS17550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FNV66_RS17560	COG0159	tryptophan synthase activity
FNV66_RS17565	COG0133	tryptophan synthase activity
FNV66_RS17575	COG0134	indole-3-glycerol-phosphate synthase activity
FNV66_RS17600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FNV66_RS17620	COG0107	imidazoleglycerol-phosphate synthase activity
FNV66_RS17625	COG0251	oxidation-reduction process
FNV66_RS17630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FNV66_RS17635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FNV66_RS17645	COG0131	Imidazoleglycerol-phosphate dehydratase
FNV66_RS17650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNV66_RS17655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FNV66_RS17675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FNV66_RS17695	COG1432	Conserved Protein
FNV66_RS17705	COG0587	DNA-directed DNA polymerase activity
FNV66_RS17760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FNV66_RS17770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FNV66_RS17775	COG3599	regulation of cell shape
FNV66_RS17785	COG1799	cell septum assembly
FNV66_RS17800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FNV66_RS17810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FNV66_RS17820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FNV66_RS17825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FNV66_RS17835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FNV66_RS17840	COG0768	penicillin binding
FNV66_RS17850	COG0275	rRNA processing
FNV66_RS17860	COG0714	Associated with various cellular activities
FNV66_RS17880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FNV66_RS17900	COG1309	transcriptional regulator
FNV66_RS17925	COG0352	thiamine-phosphate diphosphorylase activity
FNV66_RS17945	COG2022	thiamine diphosphate biosynthetic process
FNV66_RS17945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV66_RS17955	COG2022	thiamine diphosphate biosynthetic process
FNV66_RS17960	COG2815	serine threonine protein kinase
FNV66_RS17960	COG0515	serine threonine protein kinase
FNV66_RS17965	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FNV66_RS17970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FNV66_RS17975	COG2193	ferroxidase activity
FNV66_RS17980	COG0243	molybdopterin cofactor binding
FNV66_RS17985	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FNV66_RS18005	COG0205	6-phosphofructokinase activity
FNV66_RS18010	COG2197	response regulator
FNV66_RS18015	COG4585	Histidine kinase
FNV66_RS18040	COG1940	carbohydrate kinase activity
FNV66_RS18050	COG0003	Pfam Anion-transporting ATPase
FNV66_RS18085	COG0534	Mate efflux family protein
FNV66_RS18105	COG0791	NLP P60 protein
FNV66_RS18105	COG1388	LysM domain
FNV66_RS18105	COG3103	Sh3 type 3 domain protein
FNV66_RS18130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FNV66_RS18135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FNV66_RS18140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FNV66_RS18145	COG0723	plastoquinol--plastocyanin reductase activity
FNV66_RS18150	COG2010	Cytochrome c
FNV66_RS18155	COG1845	cytochrome c oxidase, subunit III
FNV66_RS18165	COG1376	ErfK ybiS ycfS ynhG family protein
FNV66_RS18175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FNV66_RS18180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FNV66_RS18190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV66_RS18210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FNV66_RS18215	COG2197	response regulator
FNV66_RS18240	COG2226	methyltransferase
FNV66_RS18245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FNV66_RS18265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FNV66_RS18270	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FNV66_RS18270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FNV66_RS18285	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FNV66_RS18290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FNV66_RS18295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FNV66_RS18300	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV66_RS18315	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FNV66_RS18345	COG0454	-acetyltransferase
FNV66_RS18365	COG0321	lipoyl(octanoyl) transferase activity
FNV66_RS18370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FNV66_RS18390	COG0174	glutamine synthetase
FNV66_RS18400	COG0501	Belongs to the peptidase M48B family
FNV66_RS18445	COG0745	RESPONSE REGULATOR receiver
FNV66_RS18460	COG2197	response regulator
FNV66_RS18490	COG1309	transcriptional regulator
FNV66_RS18525	COG1175	transmembrane transport
FNV66_RS18530	COG3833	ABC-type maltose transport systems, permease component
FNV66_RS18535	COG0366	Alpha amylase catalytic
FNV66_RS18540	COG1609	Transcriptional regulator
FNV66_RS18550	COG0583	DNA-binding transcription factor activity
FNV66_RS18555	COG0697	spore germination
FNV66_RS18560	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FNV66_RS18565	COG3511	phospholipase C
FNV66_RS18605	COG0174	glutamine synthetase
FNV66_RS18610	COG1017	nitric oxide dioxygenase activity
FNV66_RS18610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FNV66_RS18615	COG1959	2 iron, 2 sulfur cluster binding
FNV66_RS18635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FNV66_RS18635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FNV66_RS18640	COG2814	Major facilitator Superfamily
FNV66_RS18655	COG0477	Major facilitator Superfamily
FNV66_RS18660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FNV66_RS18680	COG1994	Peptidase M50
FNV66_RS18735	COG2822	iron ion transport
FNV66_RS18740	COG2837	iron assimilation
FNV66_RS18745	COG0672	)-iron permease
FNV66_RS18755	COG0495	leucyl-tRNA aminoacylation
FNV66_RS18765	COG1834	amidinotransferase
FNV66_RS18775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV66_RS18780	COG2814	Major facilitator Superfamily
FNV66_RS18805	COG1136	(ABC) transporter
FNV66_RS18810	COG0667	Aldo Keto reductase
FNV66_RS18820	COG2259	Doxx family
FNV66_RS18835	COG0406	alpha-ribazole phosphatase activity
FNV66_RS18845	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS18850	COG0673	inositol 2-dehydrogenase activity
FNV66_RS18860	COG0583	DNA-binding transcription factor activity
FNV66_RS18885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FNV66_RS18915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FNV66_RS18990	COG3022	response to hydroperoxide
FNV66_RS18995	COG0800	Aldolase
FNV66_RS19020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FNV66_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS19050	COG2030	dehydratase
FNV66_RS19055	COG1131	(ABC) transporter
FNV66_RS19065	COG4585	Histidine kinase
FNV66_RS19075	COG2197	response regulator
FNV66_RS19095	COG0183	Belongs to the thiolase family
FNV66_RS19100	COG0477	Major facilitator Superfamily
FNV66_RS19110	COG0860	N-Acetylmuramoyl-L-alanine amidase
FNV66_RS19120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS19145	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS19150	COG1309	transcriptional regulator
FNV66_RS19210	COG3845	ABC transporter
FNV66_RS19230	COG3619	membrane
FNV66_RS19255	COG0183	Belongs to the thiolase family
FNV66_RS19260	COG2124	cytochrome p450
FNV66_RS19280	COG4122	O-methyltransferase activity
FNV66_RS19360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FNV66_RS19365	COG1335	isochorismatase
FNV66_RS19370	COG0477	Major facilitator Superfamily
FNV66_RS19390	COG1733	regulation of RNA biosynthetic process
FNV66_RS19495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNV66_RS19510	COG1358	cellular component organization or biogenesis
FNV66_RS19555	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FNV66_RS19560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV66_RS19565	COG0477	Major facilitator Superfamily
FNV66_RS19570	COG1309	transcriptional regulator
FNV66_RS19585	COG0667	Aldo Keto reductase
FNV66_RS19590	COG0789	Transcriptional regulator
FNV66_RS19605	COG1741	Belongs to the pirin family
FNV66_RS19620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV66_RS19625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV66_RS19630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV66_RS19660	COG1309	transcriptional regulator
FNV66_RS19675	COG2084	Dehydrogenase
FNV66_RS19705	COG1764	response to oxidative stress
FNV66_RS19710	COG2130	NADP-dependent
FNV66_RS19725	COG4948	Mandelate Racemase Muconate Lactonizing
FNV66_RS19750	COG4214	carbohydrate transport
FNV66_RS19760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNV66_RS19795	COG1764	response to oxidative stress
FNV66_RS19825	COG0596	Alpha beta hydrolase
FNV66_RS19845	COG2318	DinB family
FNV66_RS19870	COG3507	Belongs to the glycosyl hydrolase 43 family
FNV66_RS19875	COG0395	ABC-type sugar transport system, permease component
FNV66_RS19880	COG1175	transmembrane transport
FNV66_RS19890	COG3386	PFAM SMP-30 Gluconolaconase
FNV66_RS19895	COG1414	Transcriptional regulator
FNV66_RS19925	COG4981	capsule polysaccharide biosynthetic process
FNV66_RS20000	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS20005	COG0825	malonyl-CoA metabolic process
FNV66_RS20005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FNV66_RS20010	COG1404	Belongs to the peptidase S8 family
FNV66_RS20015	COG1077	Cell shape determining protein MreB Mrl
FNV66_RS20060	COG0559	Belongs to the binding-protein-dependent transport system permease family
FNV66_RS20080	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS20115	COG1070	Carbohydrate kinase
FNV66_RS20130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FNV66_RS20135	COG0358	DNA primase activity
FNV66_RS20145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FNV66_RS20155	COG2949	membrane
FNV66_RS20215	COG2146	nitrite reductase [NAD(P)H] activity
FNV66_RS20215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FNV66_RS20225	COG1309	transcriptional regulator
FNV66_RS20230	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS20235	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS20245	COG1136	(ABC) transporter
FNV66_RS20270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FNV66_RS20270	COG0574	Belongs to the PEP-utilizing enzyme family
FNV66_RS20275	COG1940	carbohydrate kinase activity
FNV66_RS20275	COG1846	Transcriptional regulator
FNV66_RS20310	COG0477	Major facilitator Superfamily
FNV66_RS20340	COG0667	Aldo Keto reductase
FNV66_RS20350	COG1309	transcriptional regulator
FNV66_RS20355	COG0300	oxidoreductase activity
FNV66_RS20360	COG0423	glycine-tRNA ligase activity
FNV66_RS20365	COG0803	Belongs to the bacterial solute-binding protein 9 family
FNV66_RS20370	COG1121	(ABC) transporter
FNV66_RS20375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FNV66_RS20385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FNV66_RS20390	COG1381	Involved in DNA repair and RecF pathway recombination
FNV66_RS20410	COG0515	serine threonine protein kinase
FNV66_RS20410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FNV66_RS20445	COG0456	acetyltransferase
FNV66_RS20450	COG2197	response regulator
FNV66_RS20455	COG4585	Histidine kinase
FNV66_RS20460	COG1131	(ABC) transporter
FNV66_RS20475	COG2186	Transcriptional regulator
FNV66_RS20480	COG0747	negative chemotaxis
FNV66_RS20490	COG0444	Belongs to the ABC transporter superfamily
FNV66_RS20495	COG4608	Belongs to the ABC transporter superfamily
FNV66_RS20500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV66_RS20515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FNV66_RS20530	COG2723	6-phospho-beta-galactosidase activity
FNV66_RS20570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FNV66_RS20590	COG2315	Protein conserved in bacteria
FNV66_RS20600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FNV66_RS20620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV66_RS20625	COG1234	tRNA 3'-trailer cleavage
FNV66_RS20630	COG0537	adenosine 5'-monophosphoramidase activity
FNV66_RS20635	COG4946	Tricorn protease homolog
FNV66_RS20635	COG0793	Belongs to the peptidase S41A family
FNV66_RS20660	COG0484	heat shock protein binding
FNV66_RS20665	COG1420	regulation of RNA biosynthetic process
FNV66_RS20705	COG0481	GTPase activity
FNV66_RS20710	COG0268	Binds directly to 16S ribosomal RNA
FNV66_RS20735	COG1555	photosystem II stabilization
FNV66_RS20735	COG1596	polysaccharide export
FNV66_RS20740	COG1307	EDD domain protein, DegV family
FNV66_RS20750	COG0495	leucyl-tRNA aminoacylation
FNV66_RS20785	COG0477	Major facilitator Superfamily
FNV66_RS20800	COG0588	phosphoglycerate mutase activity
FNV66_RS20805	COG0799	negative regulation of ribosome biogenesis
FNV66_RS20815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FNV66_RS20830	COG0501	Belongs to the peptidase M48B family
FNV66_RS20845	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FNV66_RS20855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FNV66_RS20860	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS20865	COG0463	Glycosyl transferase, family 2
FNV66_RS20865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV66_RS20870	COG0463	Glycosyl transferase, family 2
FNV66_RS20870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV66_RS20880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FNV66_RS20885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FNV66_RS20890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FNV66_RS20895	COG1530	ribonuclease E activity
FNV66_RS20925	COG1309	transcriptional regulator
FNV66_RS20930	COG0300	oxidoreductase activity
FNV66_RS20945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV66_RS20955	COG0640	Transcriptional regulator
FNV66_RS20960	COG2226	methyltransferase
FNV66_RS20970	COG0477	Major facilitator Superfamily
FNV66_RS21000	COG0772	Belongs to the SEDS family
FNV66_RS21005	COG0768	penicillin binding
FNV66_RS21020	COG1077	Cell shape determining protein MreB Mrl
FNV66_RS21025	COG0105	UTP biosynthetic process
FNV66_RS21035	COG0285	dihydrofolate synthase activity
FNV66_RS21040	COG0525	valine-tRNA ligase activity
FNV66_RS21050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FNV66_RS21055	COG0740	serine-type endopeptidase activity
FNV66_RS21060	COG0740	serine-type endopeptidase activity
FNV66_RS21065	COG0544	peptidyl-prolyl cis-trans isomerase activity
FNV66_RS21095	COG3594	Acyltransferase
FNV66_RS21110	COG4552	Acetyltransferase involved in intracellular survival and related
FNV66_RS21125	COG1113	amino acid transport
FNV66_RS21140	COG1268	BioY protein
FNV66_RS21145	COG1940	carbohydrate kinase activity
FNV66_RS21155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV66_RS21160	COG1116	anion transmembrane transporter activity
FNV66_RS21165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS21175	COG1113	amino acid transport
FNV66_RS21180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FNV66_RS21185	COG0588	phosphoglycerate mutase activity
FNV66_RS21195	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FNV66_RS21275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FNV66_RS21310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV66_RS21335	COG1122	ATPase activity
FNV66_RS21360	COG0668	transmembrane transport
FNV66_RS21395	COG1175	transmembrane transport
FNV66_RS21400	COG0395	ABC-type sugar transport system, permease component
FNV66_RS21405	COG1486	melibiose metabolic process
FNV66_RS21420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV66_RS21450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FNV66_RS21455	COG2346	COG2346, Truncated hemoglobins
FNV66_RS21495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV66_RS21500	COG0489	protein tyrosine kinase activity
FNV66_RS21520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FNV66_RS21545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FNV66_RS21580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FNV66_RS21590	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FNV66_RS21685	COG0629	single-stranded DNA binding
FNV66_RS21790	COG3962	Belongs to the TPP enzyme family
FNV66_RS21795	COG3718	enzyme involved in inositol metabolism
FNV66_RS21805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV66_RS21830	COG2409	Drug exporters of the RND superfamily
FNV66_RS21860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FNV66_RS21875	COG1129	ABC transporter
FNV66_RS21885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV66_RS21890	COG1869	D-ribose catabolic process
FNV66_RS21910	COG0673	inositol 2-dehydrogenase activity
FNV66_RS21915	COG1609	Transcriptional regulator
FNV66_RS21920	COG1846	Transcriptional regulator
FNV66_RS21920	COG0456	acetyltransferase
FNV66_RS21930	COG0181	hydroxymethylbilane synthase activity
FNV66_RS21935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FNV66_RS21940	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV66_RS21980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV66_RS21985	COG2356	endonuclease I
FNV66_RS21990	COG0028	Belongs to the TPP enzyme family
FNV66_RS22000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV66_RS22020	COG1946	Acyl-CoA thioesterase
FNV66_RS22035	COG1309	transcriptional regulator
FNV66_RS22040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV66_RS22055	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS22090	COG0076	glutamate decarboxylase activity
FNV66_RS22095	COG3486	L-lysine 6-monooxygenase (NADPH) activity
FNV66_RS22130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FNV66_RS22140	COG0589	response to stress
FNV66_RS22150	COG4977	sequence-specific DNA binding
FNV66_RS22155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FNV66_RS22190	COG0395	ABC-type sugar transport system, permease component
FNV66_RS22205	COG3979	chitinase
FNV66_RS22215	COG0745	RESPONSE REGULATOR receiver
FNV66_RS22240	COG0406	alpha-ribazole phosphatase activity
FNV66_RS22290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS22320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV66_RS22325	COG0765	amino acid transport
FNV66_RS22330	COG0765	amino acid transport
FNV66_RS22335	COG1126	abc transporter atp-binding protein
FNV66_RS22350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV66_RS22365	COG1362	aminopeptidase activity
FNV66_RS22385	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS22395	COG3397	chitin binding
FNV66_RS22470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV66_RS22475	COG2188	Transcriptional regulator
FNV66_RS22490	COG0673	inositol 2-dehydrogenase activity
FNV66_RS22495	COG4702	Belongs to the UPF0303 family
FNV66_RS22505	COG0706	membrane insertase activity
FNV66_RS22505	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
FNV66_RS22525	COG3764	Sortase (surface protein transpeptidase)
FNV66_RS22535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FNV66_RS22555	COG0270	DNA (cytosine-5-)-methyltransferase activity
FNV66_RS22585	COG1074	ATP-dependent DNA helicase activity
FNV66_RS22625	COG0590	tRNA wobble adenosine to inosine editing
FNV66_RS22635	COG1403	HNH endonuclease
FNV66_RS22645	COG3250	beta-galactosidase activity
FNV66_RS22660	COG1846	Transcriptional regulator
FNV66_RS22690	COG2733	membrane
FNV66_RS22705	COG1131	(ABC) transporter
FNV66_RS22720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNV66_RS22750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FNV66_RS22760	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FNV66_RS22765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FNV66_RS22770	COG1263	PTS System
FNV66_RS22775	COG1263	PTS System
FNV66_RS22790	COG3631	Ketosteroid isomerase-related protein
FNV66_RS22825	COG1113	amino acid transport
FNV66_RS22835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FNV66_RS22845	COG1335	isochorismatase
FNV66_RS22880	COG0277	FAD linked oxidase domain protein
FNV66_RS22890	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FNV66_RS22900	COG1174	glycine betaine transport
FNV66_RS22920	COG3480	Lon protease (S16) C-terminal proteolytic domain
FNV66_RS22925	COG4948	Mandelate Racemase Muconate Lactonizing
FNV66_RS22935	COG0049	tRNA binding
FNV66_RS22955	COG0531	amino acid
FNV66_RS23010	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FNV66_RS23015	COG0395	ABC-type sugar transport system, permease component
FNV66_RS23020	COG1175	transmembrane transport
FNV66_RS23025	COG1653	transport
FNV66_RS23035	COG1678	Uncharacterized ACR, COG1678
FNV66_RS23040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FNV66_RS23045	COG0776	regulation of translation
FNV66_RS23055	COG3973	AAA domain
FNV66_RS23085	COG2223	nitrite transmembrane transporter activity
FNV66_RS23105	COG0583	DNA-binding transcription factor activity
FNV66_RS23120	COG1175	transmembrane transport
FNV66_RS23125	COG0395	ABC-type sugar transport system, permease component
FNV66_RS23130	COG1501	Belongs to the glycosyl hydrolase 31 family
FNV66_RS23135	COG1609	Transcriptional regulator
FNV66_RS23160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FNV66_RS23165	COG0793	Belongs to the peptidase S41A family
FNV66_RS23175	COG2884	Cell division ATP-binding protein ftsE
FNV66_RS23190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FNV66_RS23195	COG0515	serine threonine protein kinase
FNV66_RS23200	COG0515	serine threonine protein kinase
FNV66_RS23225	COG0395	ABC-type sugar transport system, permease component
FNV66_RS23230	COG0463	Glycosyl transferase, family 2
FNV66_RS23230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV66_RS23235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV66_RS23240	COG1216	Glycosyl transferase, family 2
FNV66_RS23255	COG1764	response to oxidative stress
FNV66_RS23260	COG1846	Transcriptional regulator
FNV66_RS23275	COG1216	Glycosyl transferase, family 2
FNV66_RS23300	COG2197	response regulator
FNV66_RS23325	COG1134	teichoic acid transport
FNV66_RS23330	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS23335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV66_RS23335	COG0463	Glycosyl transferase, family 2
FNV66_RS23345	COG2902	Dehydrogenase
FNV66_RS23370	COG0653	protein targeting
FNV66_RS23380	COG3214	Protein conserved in bacteria
FNV66_RS23385	COG2197	response regulator
FNV66_RS23390	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FNV66_RS23400	COG0823	Involved in the tonB-independent uptake of proteins
FNV66_RS23405	COG5002	protein histidine kinase activity
FNV66_RS23405	COG5000	phosphorelay sensor kinase activity
FNV66_RS23410	COG0745	RESPONSE REGULATOR receiver
FNV66_RS23415	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FNV66_RS23435	COG0714	Associated with various cellular activities
FNV66_RS23475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FNV66_RS23485	COG1482	cell wall glycoprotein biosynthetic process
FNV66_RS23495	COG2835	tetraacyldisaccharide 4'-kinase activity
FNV66_RS23500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FNV66_RS23540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FNV66_RS23545	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FNV66_RS23545	COG0778	Nitroreductase
FNV66_RS23555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FNV66_RS23575	COG1316	TRANSCRIPTIONal
FNV66_RS23595	COG1316	TRANSCRIPTIONal
FNV66_RS23605	COG1011	Hydrolase
FNV66_RS23615	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS23620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FNV66_RS23660	COG2205	protein histidine kinase activity
FNV66_RS23665	COG0745	RESPONSE REGULATOR receiver
FNV66_RS23670	COG3104	oligopeptide transport
FNV66_RS23735	COG1366	Belongs to the anti-sigma-factor antagonist family
FNV66_RS23740	COG1191	sigma factor activity
FNV66_RS23750	COG1228	amidohydrolase
FNV66_RS23760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV66_RS23765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FNV66_RS23805	COG2986	histidine ammonia-lyase
FNV66_RS23815	COG1174	glycine betaine transport
FNV66_RS23820	COG1174	glycine betaine transport
FNV66_RS23830	COG1609	Transcriptional regulator
FNV66_RS23845	COG0288	reversible hydration of carbon dioxide
FNV66_RS23860	COG2755	lipolytic protein G-D-S-L family
FNV66_RS23865	COG0183	Belongs to the thiolase family
FNV66_RS23905	COG0577	efflux transmembrane transporter activity
FNV66_RS23905	COG1136	(ABC) transporter
FNV66_RS23910	COG0577	efflux transmembrane transporter activity
FNV66_RS23915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FNV66_RS23920	COG1252	NADH dehydrogenase
FNV66_RS23940	COG0148	phosphopyruvate hydratase activity
FNV66_RS23955	COG2124	cytochrome p450
FNV66_RS24090	COG1309	transcriptional regulator
FNV66_RS24105	COG1136	(ABC) transporter
FNV66_RS24105	COG0577	efflux transmembrane transporter activity
FNV66_RS24110	COG1136	(ABC) transporter
FNV66_RS24115	COG0477	Major facilitator Superfamily
FNV66_RS24125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV66_RS24155	COG4585	Histidine kinase
FNV66_RS24170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FNV66_RS24175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FNV66_RS24180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FNV66_RS24185	COG0193	aminoacyl-tRNA hydrolase activity
FNV66_RS24195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FNV66_RS24205	COG1309	transcriptional regulator
FNV66_RS24215	COG4106	trans-aconitate 2-methyltransferase activity
FNV66_RS24225	COG2197	response regulator
FNV66_RS24235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FNV66_RS24280	COG0488	(ABC) transporter
FNV66_RS24290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FNV66_RS24295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FNV66_RS24305	COG0084	hydrolase, TatD family'
FNV66_RS24350	COG3224	Antibiotic biosynthesis monooxygenase
FNV66_RS24355	COG0590	tRNA wobble adenosine to inosine editing
FNV66_RS24360	COG0768	penicillin binding
FNV66_RS24385	COG0310	cobalt ion transport
FNV66_RS24395	COG1122	ATPase activity
FNV66_RS24400	COG1846	Transcriptional regulator
FNV66_RS24405	COG1764	response to oxidative stress
FNV66_RS24425	COG0667	Aldo Keto reductase
FNV66_RS24435	COG2409	Drug exporters of the RND superfamily
FNV66_RS24445	COG0793	Belongs to the peptidase S41A family
FNV66_RS24445	COG4946	Tricorn protease homolog
FNV66_RS24455	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS24460	COG2267	carboxylic ester hydrolase activity
FNV66_RS24465	COG2072	flavoprotein involved in K transport
FNV66_RS24475	COG0708	Exodeoxyribonuclease III
FNV66_RS24495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV66_RS24500	COG0315	cyclic pyranopterin monophosphate synthase activity
FNV66_RS24500	COG0521	Mo-molybdopterin cofactor biosynthetic process
FNV66_RS24505	COG0315	cyclic pyranopterin monophosphate synthase activity
FNV66_RS24515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FNV66_RS24520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FNV66_RS24530	COG3263	regulation of cellular component size
FNV66_RS24545	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FNV66_RS24555	COG1970	mechanosensitive ion channel activity
FNV66_RS24575	COG1376	ErfK ybiS ycfS ynhG family protein
FNV66_RS24590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNV66_RS24590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNV66_RS24590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNV66_RS24600	COG1349	DNA-binding transcription factor activity
FNV66_RS24610	COG0477	Major facilitator Superfamily
FNV66_RS24630	COG1247	-acetyltransferase
FNV66_RS24635	COG3384	dioxygenase
FNV66_RS24640	COG1846	Transcriptional regulator
FNV66_RS24665	COG1414	Transcriptional regulator
FNV66_RS24765	COG3629	intracellular signal transduction
FNV66_RS24765	COG3903	Transcriptional regulator
FNV66_RS24805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV66_RS24825	COG2197	response regulator
FNV66_RS24830	COG4585	Histidine kinase
FNV66_RS24885	COG2843	Capsule synthesis protein
FNV66_RS24890	COG2197	response regulator
FNV66_RS24920	COG2197	response regulator
FNV66_RS24925	COG4585	Histidine kinase
FNV66_RS24950	COG0277	FAD linked oxidase domain protein
FNV66_RS24960	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FNV66_RS24970	COG2188	Transcriptional regulator
FNV66_RS24995	COG0386	Belongs to the glutathione peroxidase family
FNV66_RS25010	COG1686	Belongs to the peptidase S11 family
FNV66_RS25065	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FNV66_RS25085	COG1733	regulation of RNA biosynthetic process
FNV66_RS25095	COG4221	oxidoreductase activity
FNV66_RS25100	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS25105	COG2267	carboxylic ester hydrolase activity
FNV66_RS25135	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FNV66_RS25175	COG3629	intracellular signal transduction
FNV66_RS25175	COG3903	Transcriptional regulator
FNV66_RS25190	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS25205	COG1024	Enoyl-CoA hydratase
FNV66_RS25210	COG0515	serine threonine protein kinase
FNV66_RS25210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FNV66_RS25230	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS25240	COG2226	methyltransferase
FNV66_RS25245	COG0259	pyridoxamine-phosphate oxidase activity
FNV66_RS25250	COG0583	DNA-binding transcription factor activity
FNV66_RS25295	COG1024	Enoyl-CoA hydratase
FNV66_RS25300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV66_RS25320	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS25325	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS25340	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS25345	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS25355	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS25370	COG1595	DNA-templated transcription, initiation
FNV66_RS25420	COG2267	carboxylic ester hydrolase activity
FNV66_RS25430	COG4821	SIS domain
FNV66_RS25450	COG0259	pyridoxamine-phosphate oxidase activity
FNV66_RS25460	COG1024	Enoyl-CoA hydratase
FNV66_RS25465	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS25480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV66_RS25515	COG1132	(ABC) transporter
FNV66_RS25520	COG0277	FAD linked oxidase domain protein
FNV66_RS25520	COG0247	lactate metabolic process
FNV66_RS25545	COG2124	cytochrome p450
FNV66_RS25555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FNV66_RS25575	COG0789	Transcriptional regulator
FNV66_RS25585	COG0667	Aldo Keto reductase
FNV66_RS25600	COG1846	Transcriptional regulator
FNV66_RS25610	COG2252	PERMEase
FNV66_RS25620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FNV66_RS25645	COG2814	Major facilitator Superfamily
FNV66_RS25655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FNV66_RS25660	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FNV66_RS25665	COG1278	Cold shock
FNV66_RS25690	COG1061	Type III restriction enzyme res subunit
FNV66_RS25705	COG3973	AAA domain
FNV66_RS25710	COG3142	Participates in the control of copper homeostasis
FNV66_RS25745	COG1737	Transcriptional regulator
FNV66_RS25750	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FNV66_RS25755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FNV66_RS25755	COG1263	PTS System
FNV66_RS25795	COG2084	Dehydrogenase
FNV66_RS25810	COG0459	protein refolding
FNV66_RS25830	COG0463	Glycosyl transferase, family 2
FNV66_RS25885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV66_RS25900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FNV66_RS25925	COG0308	aminopeptidase N
FNV66_RS25955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV66_RS25955	COG0723	plastoquinol--plastocyanin reductase activity
FNV66_RS26015	COG3842	ATPase activity
FNV66_RS26035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FNV66_RS26040	COG0215	cysteine-tRNA ligase activity
FNV66_RS26045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FNV66_RS26050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FNV66_RS26055	COG1329	Transcriptional regulator
FNV66_RS26070	COG5002	protein histidine kinase activity
FNV66_RS26105	COG0588	phosphoglycerate mutase activity
FNV66_RS26135	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS26170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV66_RS26175	COG1090	epimerase
FNV66_RS26180	COG1595	DNA-templated transcription, initiation
FNV66_RS26190	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS26200	COG1309	transcriptional regulator
FNV66_RS26205	COG1063	alcohol dehydrogenase
FNV66_RS26230	COG2188	Transcriptional regulator
FNV66_RS26240	COG2188	Transcriptional regulator
FNV66_RS26250	COG4552	Acetyltransferase involved in intracellular survival and related
FNV66_RS26265	COG1490	D-aminoacyl-tRNA deacylase activity
FNV66_RS26270	COG0354	folic acid binding
FNV66_RS26280	COG3485	protocatechuate 3,4-dioxygenase
FNV66_RS26315	COG2897	thiosulfate sulfurtransferase activity
FNV66_RS26340	COG0745	RESPONSE REGULATOR receiver
FNV66_RS26345	COG1609	Transcriptional regulator
FNV66_RS26375	COG0745	RESPONSE REGULATOR receiver
FNV66_RS26380	COG1132	(ABC) transporter
FNV66_RS26395	COG0737	Belongs to the 5'-nucleotidase family
FNV66_RS26400	COG0456	acetyltransferase
FNV66_RS26415	COG1131	(ABC) transporter
FNV66_RS26430	COG1725	Transcriptional regulator
FNV66_RS26435	COG1131	(ABC) transporter
FNV66_RS26450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FNV66_RS26480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FNV66_RS26485	COG0306	phosphate transporter
FNV66_RS26495	COG1937	Protein conserved in bacteria
FNV66_RS26515	COG0277	FAD linked oxidase domain protein
FNV66_RS26520	COG0671	phosphoesterase, PA-phosphatase related
FNV66_RS26525	COG0741	lytic transglycosylase activity
FNV66_RS26525	COG0739	heme binding
FNV66_RS26525	COG1196	nuclear chromosome segregation
FNV66_RS26630	COG1252	NADH dehydrogenase
FNV66_RS26640	COG1470	cell adhesion involved in biofilm formation
FNV66_RS26640	COG0366	Alpha amylase catalytic
FNV66_RS26660	COG0579	oxidoreductase
FNV66_RS26665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FNV66_RS26675	COG0667	Aldo Keto reductase
FNV66_RS26700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FNV66_RS26700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FNV66_RS26710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FNV66_RS26730	COG0513	Belongs to the DEAD box helicase family
FNV66_RS26770	COG1643	Atp-dependent helicase
FNV66_RS26805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FNV66_RS26825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FNV66_RS26830	COG0047	phosphoribosylformylglycinamidine synthase activity
FNV66_RS26835	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FNV66_RS26865	COG3850	Histidine kinase
FNV66_RS26870	COG2197	response regulator
FNV66_RS26880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FNV66_RS26895	COG0151	Belongs to the GarS family
FNV66_RS26980	COG0433	COG0433 Predicted ATPase
FNV66_RS26995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FNV66_RS27030	COG1191	sigma factor activity
FNV66_RS27035	COG1191	sigma factor activity
FNV66_RS27065	COG3467	pyridoxamine 5'-phosphate
FNV66_RS27075	COG0477	Major facilitator Superfamily
FNV66_RS27080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV66_RS27090	COG2205	protein histidine kinase activity
FNV66_RS27095	COG0745	RESPONSE REGULATOR receiver
FNV66_RS27105	COG2329	Antibiotic biosynthesis monooxygenase
FNV66_RS27120	COG1846	Transcriptional regulator
FNV66_RS27165	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS27170	COG1595	DNA-templated transcription, initiation
FNV66_RS27185	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS27195	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS27225	COG2318	DinB family
FNV66_RS27255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FNV66_RS27270	COG0653	protein targeting
FNV66_RS27290	COG0006	proline dipeptidase activity
FNV66_RS27305	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FNV66_RS27325	COG2409	Drug exporters of the RND superfamily
FNV66_RS27330	COG4585	Histidine kinase
FNV66_RS27365	COG2837	iron assimilation
FNV66_RS27375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FNV66_RS27380	COG0561	phosphatase activity
FNV66_RS27410	COG1131	(ABC) transporter
FNV66_RS27420	COG0789	Transcriptional regulator
FNV66_RS27425	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FNV66_RS27435	COG0561	phosphatase activity
FNV66_RS27445	COG4988	ABC transporter
FNV66_RS27450	COG1294	oxidase, subunit
FNV66_RS27455	COG1271	oxidase subunit
FNV66_RS27460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNV66_RS27465	COG1609	Transcriptional regulator
FNV66_RS27485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FNV66_RS27510	COG0662	Cupin 2, conserved barrel domain protein
FNV66_RS27515	COG1950	PFAM Membrane protein of
FNV66_RS27520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV66_RS27525	COG0626	cystathionine gamma-synthase activity
FNV66_RS27560	COG2814	Major facilitator Superfamily
FNV66_RS27580	COG0305	Participates in initiation and elongation during chromosome replication
FNV66_RS27590	COG0359	binds to the 23S rRNA
FNV66_RS27595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FNV66_RS27600	COG0629	single-stranded DNA binding
FNV66_RS27605	COG0360	Binds together with S18 to 16S ribosomal RNA
FNV66_RS27630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FNV66_RS27655	COG0617	tRNA 3'-terminal CCA addition
FNV66_RS27675	COG1595	DNA-templated transcription, initiation
FNV66_RS27685	COG0492	ferredoxin-NADP+ reductase activity
FNV66_RS27690	COG3118	belongs to the thioredoxin family
FNV66_RS27705	COG1192	Involved in chromosome partitioning
FNV66_RS27710	COG0357	Ribosomal RNA small subunit methyltransferase G
FNV66_RS27720	COG0706	membrane insertase activity
FNV66_RS27725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FNV66_RS27730	COG0594	ribonuclease P activity
FNV66_RS27735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FNV66_RS27740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FNV66_RS27745	COG0592	DNA-directed DNA polymerase activity
FNV66_RS27750	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FNV66_RS27755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FNV66_RS27760	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FNV66_RS27765	COG0187	DNA topoisomerase II activity
FNV66_RS27770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FNV66_RS27805	COG0515	serine threonine protein kinase
FNV66_RS27830	COG0705	Rhomboid family
FNV66_RS27845	COG3764	Sortase (surface protein transpeptidase)
FNV66_RS27860	COG3764	Sortase (surface protein transpeptidase)
FNV66_RS27865	COG3764	Sortase (surface protein transpeptidase)
FNV66_RS27870	COG0515	serine threonine protein kinase
FNV66_RS27875	COG0768	penicillin binding
FNV66_RS27890	COG1716	ATPase activity
FNV66_RS27895	COG1716	ATPase activity
FNV66_RS27925	COG0745	RESPONSE REGULATOR receiver
FNV66_RS27940	COG4770	biotin carboxylase activity
FNV66_RS27955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV66_RS28000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV66_RS28030	COG0475	glutathione-regulated potassium exporter activity
FNV66_RS28040	COG1733	regulation of RNA biosynthetic process
FNV66_RS28045	COG0477	Major facilitator Superfamily
FNV66_RS28065	COG0277	FAD linked oxidase domain protein
FNV66_RS28085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FNV66_RS28090	COG1733	regulation of RNA biosynthetic process
FNV66_RS28135	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV66_RS28140	COG1309	transcriptional regulator
FNV66_RS28145	COG1522	sequence-specific DNA binding
FNV66_RS28165	COG0746	molybdenum cofactor guanylyltransferase activity
FNV66_RS28180	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS28180	COG0604	alcohol dehydrogenase
FNV66_RS28180	COG3321	synthase
FNV66_RS28195	COG0515	serine threonine protein kinase
FNV66_RS28200	COG0515	serine threonine protein kinase
FNV66_RS28225	COG0022	dehydrogenase e1 component
FNV66_RS28230	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV66_RS28285	COG1362	aminopeptidase activity
FNV66_RS28290	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS28300	COG1741	Belongs to the pirin family
FNV66_RS28315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FNV66_RS28345	COG3866	Pectate lyase
FNV66_RS28355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNV66_RS28370	COG1289	transmembrane transporter activity
FNV66_RS28380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FNV66_RS28385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV66_RS28415	COG2205	protein histidine kinase activity
FNV66_RS28420	COG0745	RESPONSE REGULATOR receiver
FNV66_RS28435	COG1653	transport
FNV66_RS28440	COG1473	amidohydrolase
FNV66_RS28460	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FNV66_RS28470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNV66_RS28505	COG1278	Cold shock
FNV66_RS28540	COG0725	ABC transporter, periplasmic molybdate-binding protein
FNV66_RS28590	COG0515	serine threonine protein kinase
FNV66_RS28590	COG2815	serine threonine protein kinase
FNV66_RS28605	COG1595	DNA-templated transcription, initiation
FNV66_RS28615	COG0561	phosphatase activity
FNV66_RS28660	COG0745	RESPONSE REGULATOR receiver
FNV66_RS28665	COG5002	protein histidine kinase activity
FNV66_RS28675	COG2409	Drug exporters of the RND superfamily
FNV66_RS28680	COG4585	Histidine kinase
FNV66_RS28685	COG2197	response regulator
FNV66_RS28705	COG0640	Transcriptional regulator
FNV66_RS28710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FNV66_RS28720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FNV66_RS28790	COG2326	polyphosphate kinase activity
FNV66_RS28795	COG3387	PFAM Glycoside hydrolase 15-related
FNV66_RS28800	COG0477	Major facilitator Superfamily
FNV66_RS28830	COG1063	alcohol dehydrogenase
FNV66_RS28875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FNV66_RS28890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FNV66_RS28890	COG0515	serine threonine protein kinase
FNV66_RS28915	COG1733	regulation of RNA biosynthetic process
FNV66_RS28940	COG2205	protein histidine kinase activity
FNV66_RS28945	COG0745	RESPONSE REGULATOR receiver
FNV66_RS29010	COG0717	Belongs to the dCTP deaminase family
FNV66_RS29035	COG2181	nitrate reductase activity
FNV66_RS29035	COG0247	lactate metabolic process
FNV66_RS29040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FNV66_RS29045	COG0443	Heat shock 70 kDa protein
FNV66_RS29050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FNV66_RS29055	COG0484	heat shock protein binding
FNV66_RS29060	COG0789	Transcriptional regulator
FNV66_RS29065	COG4213	ABC transporter substrate-binding protein
FNV66_RS29085	COG1305	Transglutaminase-like
FNV66_RS29125	COG0542	response to heat
FNV66_RS29150	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FNV66_RS29165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FNV66_RS29170	COG0191	fructose-bisphosphate aldolase activity
FNV66_RS29190	COG3844	kynureninase activity
FNV66_RS29215	COG4585	Histidine kinase
FNV66_RS29220	COG2197	response regulator
FNV66_RS29230	COG2197	response regulator
FNV66_RS29245	COG3559	Exporter of polyketide antibiotics
FNV66_RS29250	COG1131	(ABC) transporter
FNV66_RS29265	COG4303	Ethanolamine ammonia lyase large subunit
FNV66_RS29280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FNV66_RS29285	COG0737	Belongs to the 5'-nucleotidase family
FNV66_RS29295	COG1802	Transcriptional regulator
FNV66_RS29305	COG0693	protein deglycase activity
FNV66_RS29325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FNV66_RS29330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FNV66_RS29365	COG5002	protein histidine kinase activity
FNV66_RS29365	COG5000	phosphorelay sensor kinase activity
FNV66_RS29440	COG0515	serine threonine protein kinase
FNV66_RS29480	COG4152	abc transporter atp-binding protein
FNV66_RS29540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FNV66_RS29555	COG1132	(ABC) transporter
FNV66_RS29580	COG1408	metallophosphoesterase
FNV66_RS29600	COG0003	Pfam Anion-transporting ATPase
FNV66_RS29625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV66_RS29650	COG0596	Alpha beta hydrolase
FNV66_RS29660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FNV66_RS29665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV66_RS29670	COG0659	secondary active sulfate transmembrane transporter activity
FNV66_RS29730	COG1205	dead DEAH box helicase
FNV66_RS29730	COG1111	helicase
FNV66_RS29735	COG1366	Belongs to the anti-sigma-factor antagonist family
FNV66_RS29740	COG2172	sigma factor antagonist activity
FNV66_RS29745	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FNV66_RS29760	COG2815	serine threonine protein kinase
FNV66_RS29760	COG0515	serine threonine protein kinase
FNV66_RS29770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FNV66_RS29770	COG1754	DNA topoisomerase type I activity
FNV66_RS29775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FNV66_RS29780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FNV66_RS29825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FNV66_RS29825	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FNV66_RS29860	COG1136	(ABC) transporter
FNV66_RS29870	COG2197	response regulator
FNV66_RS29940	COG3903	Transcriptional regulator
FNV66_RS29940	COG3629	intracellular signal transduction
FNV66_RS29945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNV66_RS29945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNV66_RS29970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FNV66_RS29975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FNV66_RS29980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FNV66_RS29985	COG0254	rRNA binding
FNV66_RS29995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FNV66_RS30015	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS30035	COG0076	glutamate decarboxylase activity
FNV66_RS30045	COG0789	Transcriptional regulator
FNV66_RS30050	COG0393	Putative heavy-metal-binding
FNV66_RS30065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FNV66_RS30070	COG2027	D-alanyl-D-alanine carboxypeptidase
FNV66_RS30080	COG0037	tRNA processing
FNV66_RS30095	COG0302	gtp cyclohydrolase
FNV66_RS30110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FNV66_RS30125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FNV66_RS30125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FNV66_RS30150	COG0649	NAD binding
FNV66_RS30165	COG2197	response regulator
FNV66_RS30170	COG1660	Displays ATPase and GTPase activities
FNV66_RS30195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FNV66_RS30200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FNV66_RS30210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FNV66_RS30230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FNV66_RS30255	COG0739	heme binding
FNV66_RS30270	COG2205	protein histidine kinase activity
FNV66_RS30275	COG0745	RESPONSE REGULATOR receiver
FNV66_RS30285	COG1595	DNA-templated transcription, initiation
FNV66_RS30300	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FNV66_RS30320	COG0248	Ppx GppA phosphatase
FNV66_RS30325	COG1082	Xylose isomerase domain protein TIM barrel
FNV66_RS30330	COG1309	transcriptional regulator
FNV66_RS30335	COG0129	dihydroxy-acid dehydratase activity
FNV66_RS30340	COG0515	serine threonine protein kinase
FNV66_RS30340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FNV66_RS30350	COG4991	sh3 domain protein
FNV66_RS30360	COG2226	methyltransferase
FNV66_RS30370	COG0842	Transport permease protein
FNV66_RS30370	COG1129	ABC transporter
FNV66_RS30380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FNV66_RS30385	COG0180	Tryptophanyl-tRNA synthetase
FNV66_RS30420	COG0123	including yeast histone deacetylase and acetoin utilization protein
FNV66_RS30470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FNV66_RS30475	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FNV66_RS30480	COG0181	hydroxymethylbilane synthase activity
FNV66_RS30485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FNV66_RS30485	COG1648	precorrin-2 dehydrogenase activity
FNV66_RS30490	COG0113	porphobilinogen synthase activity
FNV66_RS30520	COG0018	arginyl-trna synthetase
FNV66_RS30525	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FNV66_RS30545	COG1690	Belongs to the RtcB family
FNV66_RS30565	COG1742	UPF0060 membrane protein
FNV66_RS30575	COG1846	Transcriptional regulator
FNV66_RS30580	COG1733	regulation of RNA biosynthetic process
FNV66_RS30595	COG0583	DNA-binding transcription factor activity
FNV66_RS30605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS30635	COG0531	amino acid
FNV66_RS30645	COG1136	(ABC) transporter
FNV66_RS30655	COG2197	response regulator
FNV66_RS30665	COG0501	Belongs to the peptidase M48B family
FNV66_RS30675	COG1968	undecaprenyl-diphosphatase activity
FNV66_RS30700	COG0531	amino acid
FNV66_RS30720	COG0598	Magnesium transport protein CorA
FNV66_RS30725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV66_RS30735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FNV66_RS30740	COG0406	alpha-ribazole phosphatase activity
FNV66_RS30760	COG1333	cytochrome c biogenesis protein
FNV66_RS30765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FNV66_RS30810	COG2226	methyltransferase
FNV66_RS30815	COG0604	alcohol dehydrogenase
FNV66_RS30815	COG3321	synthase
FNV66_RS30815	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS30820	COG0640	Transcriptional regulator
FNV66_RS30840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FNV66_RS30845	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FNV66_RS30850	COG0163	prenyltransferase activity
FNV66_RS30860	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FNV66_RS30875	COG1309	transcriptional regulator
FNV66_RS30890	COG0183	Belongs to the thiolase family
FNV66_RS30905	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FNV66_RS30920	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FNV66_RS30950	COG2226	methyltransferase
FNV66_RS30980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV66_RS30985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV66_RS30990	COG0649	NAD binding
FNV66_RS31000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FNV66_RS31005	COG1034	ATP synthesis coupled electron transport
FNV66_RS31010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FNV66_RS31015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV66_RS31025	COG0713	ATP synthesis coupled electron transport
FNV66_RS31030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FNV66_RS31040	COG1007	ATP synthesis coupled electron transport
FNV66_RS31045	COG0514	ATP-dependent DNA helicase (RecQ)
FNV66_RS31070	COG0492	ferredoxin-NADP+ reductase activity
FNV66_RS31080	COG5280	Phage tail tape measure protein TP901
FNV66_RS31080	COG3953	SLT domain
FNV66_RS31110	COG1131	(ABC) transporter
FNV66_RS31120	COG0655	NAD(P)H dehydrogenase (quinone) activity
FNV66_RS31145	COG0702	epimerase
FNV66_RS31150	COG1733	regulation of RNA biosynthetic process
FNV66_RS31155	COG1013	pyruvate-flavodoxin oxidoreductase activity
FNV66_RS31160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FNV66_RS31160	COG0674	pyruvate-flavodoxin oxidoreductase activity
FNV66_RS31180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV66_RS31185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV66_RS31190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV66_RS31195	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FNV66_RS31200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV66_RS31205	COG0839	Belongs to the complex I subunit 6 family
FNV66_RS31210	COG0713	ATP synthesis coupled electron transport
FNV66_RS31225	COG1007	ATP synthesis coupled electron transport
FNV66_RS31230	COG0501	Belongs to the peptidase M48B family
FNV66_RS31235	COG3304	Inner membrane component domain
FNV66_RS31255	COG2261	transglycosylase associated protein
FNV66_RS31260	COG1666	GTP binding
FNV66_RS31360	COG2188	Transcriptional regulator
FNV66_RS31365	COG0515	serine threonine protein kinase
FNV66_RS31385	COG0702	epimerase
FNV66_RS31390	COG0402	S-adenosylhomocysteine deaminase activity
FNV66_RS31405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FNV66_RS31410	COG2030	dehydratase
FNV66_RS31425	COG0477	Major facilitator Superfamily
FNV66_RS31430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FNV66_RS31435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FNV66_RS31450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV66_RS31455	COG0436	Aminotransferase
FNV66_RS31475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FNV66_RS31480	COG0081	regulation of translation
FNV66_RS31495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FNV66_RS31500	COG0222	ribosome binding
FNV66_RS31505	COG0085	RNA polymerase activity
FNV66_RS31510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FNV66_RS31540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV66_RS31545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FNV66_RS31550	COG0049	tRNA binding
FNV66_RS31555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FNV66_RS31560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FNV66_RS31575	COG2124	cytochrome p450
FNV66_RS31595	COG1404	Belongs to the peptidase S8 family
FNV66_RS31620	COG0051	transcription antitermination factor activity, RNA binding
FNV66_RS31625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FNV66_RS31630	COG0088	Forms part of the polypeptide exit tunnel
FNV66_RS31635	COG0089	rRNA binding
FNV66_RS31640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FNV66_RS31645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FNV66_RS31650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FNV66_RS31655	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FNV66_RS31660	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FNV66_RS31665	COG0255	Belongs to the universal ribosomal protein uL29 family
FNV66_RS31670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FNV66_RS31675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FNV66_RS31680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FNV66_RS31685	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FNV66_RS31690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FNV66_RS31695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FNV66_RS31700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FNV66_RS31705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FNV66_RS31710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FNV66_RS31715	COG1841	ribosomal large subunit assembly
FNV66_RS31720	COG0200	Binds to the 23S rRNA
FNV66_RS31730	COG0563	adenylate kinase activity
FNV66_RS31740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FNV66_RS31745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FNV66_RS31750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FNV66_RS31755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FNV66_RS31760	COG0202	RNA polymerase activity
FNV66_RS31765	COG0203	ribosomal protein L17
FNV66_RS31770	COG0101	tRNA pseudouridine synthase activity
FNV66_RS31780	COG1215	transferase activity, transferring glycosyl groups
FNV66_RS31785	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FNV66_RS31785	COG4124	Belongs to the glycosyl hydrolase 26 family
FNV66_RS31800	COG0463	Glycosyl transferase, family 2
FNV66_RS31810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FNV66_RS31815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FNV66_RS31820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FNV66_RS31825	COG1072	(Pantothenic acid kinase))
FNV66_RS31830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FNV66_RS31875	COG0736	holo-[acyl-carrier-protein] synthase activity
FNV66_RS31890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FNV66_RS31900	COG0802	atpase or kinase
FNV66_RS31920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FNV66_RS31930	COG1609	Transcriptional regulator
FNV66_RS31940	COG1175	transmembrane transport
FNV66_RS31945	COG0395	ABC-type sugar transport system, permease component
FNV66_RS31950	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV66_RS31955	COG1609	Transcriptional regulator
FNV66_RS31980	COG4941	Belongs to the sigma-70 factor family
FNV66_RS31990	COG0726	polysaccharide deacetylase
FNV66_RS31995	COG0726	polysaccharide deacetylase
FNV66_RS32000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FNV66_RS32005	COG0459	protein refolding
FNV66_RS32015	COG4221	oxidoreductase activity
FNV66_RS32025	COG0583	DNA-binding transcription factor activity
FNV66_RS32040	COG1595	DNA-templated transcription, initiation
FNV66_RS32050	COG0516	GMP reductase activity
FNV66_RS32065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FNV66_RS32085	COG0515	serine threonine protein kinase
FNV66_RS32090	COG0515	serine threonine protein kinase
FNV66_RS32090	COG2815	serine threonine protein kinase
FNV66_RS32095	COG0515	serine threonine protein kinase
FNV66_RS32100	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS32125	COG0519	Catalyzes the synthesis of GMP from XMP
FNV66_RS32125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FNV66_RS32170	COG2197	response regulator
FNV66_RS32205	COG0739	heme binding
FNV66_RS32215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS32215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS32230	COG0714	Associated with various cellular activities
FNV66_RS32235	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FNV66_RS32240	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FNV66_RS32250	COG0045	succinate-CoA ligase (ADP-forming) activity
FNV66_RS32280	COG0138	bifunctional purine biosynthesis protein purh
FNV66_RS32300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FNV66_RS32320	COG0039	L-malate dehydrogenase activity
FNV66_RS32340	COG0456	acetyltransferase
FNV66_RS32340	COG1846	Transcriptional regulator
FNV66_RS32345	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS32355	COG4175	Glycine betaine
FNV66_RS32355	COG0517	IMP dehydrogenase activity
FNV66_RS32360	COG4176	ABC-type proline glycine betaine transport system permease component
FNV66_RS32375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS32380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS32390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS32400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV66_RS32410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV66_RS32415	COG0512	Glutamine amidotransferase of anthranilate synthase
FNV66_RS32415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FNV66_RS32420	COG3224	Antibiotic biosynthesis monooxygenase
FNV66_RS32440	COG0754	glutathionylspermidine amidase activity
FNV66_RS32445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FNV66_RS32450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FNV66_RS32460	COG0180	Tryptophanyl-tRNA synthetase
FNV66_RS32495	COG1295	ribonuclease BN
FNV66_RS32505	COG1408	metallophosphoesterase
FNV66_RS32525	COG2205	protein histidine kinase activity
FNV66_RS32530	COG0745	RESPONSE REGULATOR receiver
FNV66_RS32535	COG2409	Drug exporters of the RND superfamily
FNV66_RS32575	COG1053	succinate dehydrogenase
FNV66_RS32585	COG2009	succinate dehydrogenase
FNV66_RS32595	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FNV66_RS32625	COG1595	DNA-templated transcription, initiation
FNV66_RS32630	COG1595	DNA-templated transcription, initiation
FNV66_RS32645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS32645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS32660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FNV66_RS32670	COG1216	Glycosyl transferase, family 2
FNV66_RS32685	COG2089	acid synthase
FNV66_RS32700	COG0573	inorganic phosphate transmembrane transporter activity
FNV66_RS32730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FNV66_RS32735	COG4195	phage-related replication protein
FNV66_RS32790	COG1473	amidohydrolase
FNV66_RS32790	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FNV66_RS32795	COG1744	ABC transporter substrate-binding protein PnrA-like
FNV66_RS32800	COG1744	ABC transporter substrate-binding protein PnrA-like
FNV66_RS32840	COG0592	DNA-directed DNA polymerase activity
FNV66_RS32845	COG2814	Major facilitator Superfamily
FNV66_RS32850	COG0583	DNA-binding transcription factor activity
FNV66_RS32860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV66_RS32885	COG2205	protein histidine kinase activity
FNV66_RS32890	COG0745	RESPONSE REGULATOR receiver
FNV66_RS32895	COG1595	DNA-templated transcription, initiation
FNV66_RS32910	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS32915	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS32975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FNV66_RS32990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FNV66_RS33020	COG4770	biotin carboxylase activity
FNV66_RS33030	COG0424	maF-like protein
FNV66_RS33045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV66_RS33055	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FNV66_RS33065	COG1024	Enoyl-CoA hydratase
FNV66_RS33075	COG2986	histidine ammonia-lyase
FNV66_RS33080	COG1278	Cold shock
FNV66_RS33115	COG1136	(ABC) transporter
FNV66_RS33120	COG1404	Belongs to the peptidase S8 family
FNV66_RS33135	COG1064	alcohol dehydrogenase
FNV66_RS33140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV66_RS33145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV66_RS33155	COG2132	Multicopper oxidase
FNV66_RS33195	COG3173	Aminoglycoside phosphotransferase
FNV66_RS33220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FNV66_RS33245	COG2255	four-way junction helicase activity
FNV66_RS33250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FNV66_RS33290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FNV66_RS33300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV66_RS33325	COG1331	Highly conserved protein containing a thioredoxin domain
FNV66_RS33355	COG1309	transcriptional regulator
FNV66_RS33360	COG0477	Major facilitator Superfamily
FNV66_RS33370	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FNV66_RS33465	COG0436	Aminotransferase
FNV66_RS33480	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FNV66_RS33495	COG1414	Transcriptional regulator
FNV66_RS33500	COG0251	oxidation-reduction process
FNV66_RS33505	COG2610	gluconate transmembrane transporter activity
FNV66_RS33570	COG2894	cell division
FNV66_RS33600	COG2197	response regulator
FNV66_RS33620	COG2885	chlorophyll binding
FNV66_RS33625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FNV66_RS33655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FNV66_RS33660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FNV66_RS33675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS33680	COG0450	alkyl hydroperoxide reductase
FNV66_RS33695	COG1136	(ABC) transporter
FNV66_RS33715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNV66_RS33745	COG0114	fumarate hydratase activity
FNV66_RS33765	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FNV66_RS33765	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FNV66_RS33790	COG0778	Nitroreductase
FNV66_RS33795	COG1722	exodeoxyribonuclease VII activity
FNV66_RS33800	COG1570	exodeoxyribonuclease VII activity
FNV66_RS33810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FNV66_RS33825	COG0012	GTP binding
FNV66_RS33920	COG1053	succinate dehydrogenase
FNV66_RS33955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNV66_RS33960	COG0444	Belongs to the ABC transporter superfamily
FNV66_RS33965	COG4608	Belongs to the ABC transporter superfamily
FNV66_RS33970	COG0346	lactoylglutathione lyase activity
FNV66_RS33980	COG0601	transmembrane transport
FNV66_RS33985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNV66_RS33990	COG0444	Belongs to the ABC transporter superfamily
FNV66_RS33995	COG4608	Belongs to the ABC transporter superfamily
FNV66_RS34010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV66_RS34030	COG1131	(ABC) transporter
FNV66_RS34040	COG4585	Histidine kinase
FNV66_RS34045	COG2197	response regulator
FNV66_RS34080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV66_RS34090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FNV66_RS34100	COG0519	Catalyzes the synthesis of GMP from XMP
FNV66_RS34105	COG1024	Enoyl-CoA hydratase
FNV66_RS34125	COG1595	DNA-templated transcription, initiation
FNV66_RS34140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FNV66_RS34165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FNV66_RS34175	COG0598	Magnesium transport protein CorA
FNV66_RS34185	COG2814	Major facilitator Superfamily
FNV66_RS34200	COG2095	MarC family integral membrane protein
FNV66_RS34210	COG1432	Conserved Protein
FNV66_RS34215	COG0596	Alpha beta hydrolase
FNV66_RS34260	COG0747	negative chemotaxis
FNV66_RS34270	COG0601	transmembrane transport
FNV66_RS34330	COG0210	DNA helicase
FNV66_RS34335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV66_RS34375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FNV66_RS34430	COG3480	Lon protease (S16) C-terminal proteolytic domain
FNV66_RS34440	COG1615	UPF0182 protein
FNV66_RS34465	COG0753	catalase activity
FNV66_RS34470	COG0517	IMP dehydrogenase activity
FNV66_RS34470	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FNV66_RS34475	COG0483	inositol monophosphate 1-phosphatase activity
FNV66_RS34495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FNV66_RS34505	COG2135	peptidase activity
FNV66_RS34515	COG1595	DNA-templated transcription, initiation
FNV66_RS34520	COG5662	AntiSigma factor
FNV66_RS34525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FNV66_RS34525	COG2199	diguanylate cyclase activity
FNV66_RS34540	COG0242	peptide deformylase activity
FNV66_RS34550	COG2124	cytochrome p450
FNV66_RS34570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FNV66_RS34595	COG2188	Transcriptional regulator
FNV66_RS34600	COG2182	Extracellular solute-binding protein
FNV66_RS34605	COG1175	transmembrane transport
FNV66_RS34610	COG0395	ABC-type sugar transport system, permease component
FNV66_RS34615	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV66_RS34620	COG0363	glucosamine-6-phosphate deaminase activity
FNV66_RS34625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FNV66_RS34640	COG1597	lipid kinase activity
FNV66_RS34685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV66_RS34760	COG4106	trans-aconitate 2-methyltransferase activity
FNV66_RS34765	COG1126	abc transporter atp-binding protein
FNV66_RS34780	COG0281	malic enzyme
FNV66_RS34785	COG0604	alcohol dehydrogenase
FNV66_RS34820	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV66_RS34820	COG0567	Dehydrogenase, E1 component
FNV66_RS34825	COG2205	protein histidine kinase activity
FNV66_RS34830	COG0745	RESPONSE REGULATOR receiver
FNV66_RS34855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FNV66_RS34940	COG0701	Predicted permease
FNV66_RS34945	COG0768	penicillin binding
FNV66_RS34950	COG0772	Belongs to the SEDS family
FNV66_RS34960	COG2205	protein histidine kinase activity
FNV66_RS34985	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV66_RS34995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FNV66_RS35060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FNV66_RS35125	COG2188	Transcriptional regulator
FNV66_RS35190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FNV66_RS35235	COG1674	ftsk spoiiie
FNV66_RS35305	COG0018	arginyl-trna synthetase
FNV66_RS35310	COG0019	diaminopimelate decarboxylase activity
FNV66_RS35315	COG0460	homoserine dehydrogenase
FNV66_RS35320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FNV66_RS35325	COG0083	homoserine kinase activity
FNV66_RS35340	COG1316	TRANSCRIPTIONal
FNV66_RS35345	COG0254	rRNA binding
FNV66_RS35350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FNV66_RS35355	COG2890	protein-(glutamine-N5) methyltransferase activity
FNV66_RS35365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV66_RS35375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FNV66_RS35380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FNV66_RS35395	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FNV66_RS35400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FNV66_RS35405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FNV66_RS35410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FNV66_RS35415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FNV66_RS35420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FNV66_RS35425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FNV66_RS35440	COG2197	response regulator
FNV66_RS35465	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV66_RS35480	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FNV66_RS35525	COG1131	(ABC) transporter
FNV66_RS35545	COG0183	Belongs to the thiolase family
FNV66_RS35580	COG2814	Major facilitator Superfamily
FNV66_RS35625	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS35625	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS35660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FNV66_RS35665	COG0857	belongs to the CobB CobQ family
FNV66_RS35665	COG0280	phosphate acetyltransferase
FNV66_RS35670	COG0205	6-phosphofructokinase activity
FNV66_RS35685	COG0395	ABC-type sugar transport system, permease component
FNV66_RS35690	COG1175	transmembrane transport
FNV66_RS35715	COG4565	transcriptional regulatory protein
FNV66_RS35720	COG3290	protein histidine kinase activity
FNV66_RS35725	COG1301	dicarboxylic acid transport
FNV66_RS35735	COG0477	Major facilitator Superfamily
FNV66_RS35750	COG1522	sequence-specific DNA binding
FNV66_RS35770	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FNV66_RS35775	COG3281	Trehalose synthase
FNV66_RS35785	COG0366	Alpha amylase catalytic
FNV66_RS35795	COG0058	SHG alpha-glucan phosphorylase activity
FNV66_RS35815	COG1132	(ABC) transporter
FNV66_RS35820	COG1132	(ABC) transporter
FNV66_RS35825	COG1132	(ABC) transporter
FNV66_RS35830	COG1132	(ABC) transporter
FNV66_RS35835	COG1131	(ABC) transporter
FNV66_RS35845	COG4585	Histidine kinase
FNV66_RS35850	COG2197	response regulator
FNV66_RS35860	COG1376	ErfK ybiS ycfS ynhG family protein
FNV66_RS35865	COG1376	ErfK ybiS ycfS ynhG family protein
FNV66_RS35910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FNV66_RS35930	COG0475	glutathione-regulated potassium exporter activity
FNV66_RS35935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV66_RS35950	COG3903	Transcriptional regulator
FNV66_RS35950	COG3629	intracellular signal transduction
FNV66_RS35980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV66_RS36010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV66_RS36015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV66_RS36020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV66_RS36025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV66_RS36035	COG4122	O-methyltransferase activity
FNV66_RS36040	COG1233	COG1233 Phytoene dehydrogenase and related
FNV66_RS36070	COG3251	PFAM MbtH domain protein
FNV66_RS36075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV66_RS36075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV66_RS36085	COG0277	FAD linked oxidase domain protein
FNV66_RS36100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FNV66_RS36105	COG1760	l-serine dehydratase
FNV66_RS36110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FNV66_RS36115	COG0509	glycine decarboxylation via glycine cleavage system
FNV66_RS36120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FNV66_RS36155	COG0444	Belongs to the ABC transporter superfamily
FNV66_RS36160	COG4608	Belongs to the ABC transporter superfamily
FNV66_RS36175	COG2860	membrane
FNV66_RS36195	COG2378	regulation of single-species biofilm formation
FNV66_RS36205	COG1309	transcriptional regulator
FNV66_RS36235	COG0482	sulfurtransferase activity
FNV66_RS36245	COG1611	Belongs to the LOG family
FNV66_RS36250	COG4221	oxidoreductase activity
FNV66_RS36260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FNV66_RS36270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FNV66_RS36275	COG0154	amidase activity
FNV66_RS36285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FNV66_RS36290	COG2409	Drug exporters of the RND superfamily
FNV66_RS36295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV66_RS36310	COG2197	response regulator
FNV66_RS36320	COG2133	pyrroloquinoline quinone binding
FNV66_RS36325	COG0667	Aldo Keto reductase
FNV66_RS36335	COG5001	Diguanylate cyclase
FNV66_RS36345	COG0440	acetolactate synthase activity
FNV66_RS36350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FNV66_RS36360	COG1672	PFAM Archaeal ATPase
FNV66_RS36360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FNV66_RS36365	COG0477	Major facilitator Superfamily
FNV66_RS36385	COG3214	Protein conserved in bacteria
FNV66_RS36395	COG0506	proline dehydrogenase activity
FNV66_RS36400	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS36415	COG1082	Xylose isomerase domain protein TIM barrel
FNV66_RS36425	COG0477	Major facilitator Superfamily
FNV66_RS36435	COG0473	3-isopropylmalate dehydrogenase activity
FNV66_RS36440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FNV66_RS36460	COG0831	urea catabolic process
FNV66_RS36460	COG0832	Belongs to the urease beta subunit family
FNV66_RS36465	COG0804	urea catabolic process
FNV66_RS36470	COG2957	Belongs to the agmatine deiminase family
FNV66_RS36480	COG0477	Major facilitator Superfamily
FNV66_RS36485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FNV66_RS36510	COG2197	response regulator
FNV66_RS36520	COG1131	(ABC) transporter
FNV66_RS36555	COG4585	Histidine kinase
FNV66_RS36565	COG2353	YceI-like domain
FNV66_RS36570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV66_RS36590	COG2018	Roadblock/LC7 domain
FNV66_RS36610	COG2018	Roadblock/LC7 domain
FNV66_RS36615	COG5002	protein histidine kinase activity
FNV66_RS36625	COG0179	Fumarylacetoacetate (FAA) hydrolase
FNV66_RS36630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FNV66_RS36680	COG1414	Transcriptional regulator
FNV66_RS36685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FNV66_RS36690	COG0066	3-isopropylmalate dehydratase activity
FNV66_RS36700	COG0776	regulation of translation
FNV66_RS36710	COG1920	GTP binding
FNV66_RS36720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FNV66_RS36725	COG1181	Belongs to the D-alanine--D-alanine ligase family
FNV66_RS36750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FNV66_RS36755	COG1461	Dihydroxyacetone kinase
FNV66_RS36765	COG0326	Molecular chaperone. Has ATPase activity
FNV66_RS36775	COG0742	ribosomal rna small subunit methyltransferase
FNV66_RS36780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FNV66_RS36795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FNV66_RS36800	COG0571	ribonuclease III activity
FNV66_RS36805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FNV66_RS36810	COG1733	regulation of RNA biosynthetic process
FNV66_RS36820	COG0515	serine threonine protein kinase
FNV66_RS36820	COG2815	serine threonine protein kinase
FNV66_RS36835	COG2340	Cysteine-rich secretory protein family
FNV66_RS36840	COG1254	Belongs to the acylphosphatase family
FNV66_RS36855	COG0477	Major facilitator Superfamily
FNV66_RS36895	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FNV66_RS36905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FNV66_RS36915	COG0442	prolyl-tRNA aminoacylation
FNV66_RS36925	COG0228	four-way junction DNA binding
FNV66_RS36930	COG1837	Belongs to the UPF0109 family
FNV66_RS36935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FNV66_RS36940	COG0336	Belongs to the RNA methyltransferase TrmD family
FNV66_RS36945	COG0335	large ribosomal subunit rRNA binding
FNV66_RS36955	COG0681	Belongs to the peptidase S26 family
FNV66_RS36970	COG0494	nUDIX hydrolase
FNV66_RS36980	COG0792	nuclease activity
FNV66_RS36995	COG1191	sigma factor activity
FNV66_RS37010	COG0052	Belongs to the universal ribosomal protein uS2 family
FNV66_RS37015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FNV66_RS37020	COG0528	UMP kinase activity
FNV66_RS37025	COG0233	cytoplasmic translational termination
FNV66_RS37030	COG0575	Belongs to the CDS family
FNV66_RS37040	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FNV66_RS37050	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FNV66_RS37055	COG3842	ATPase activity
FNV66_RS37085	COG1136	(ABC) transporter
FNV66_RS37090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FNV66_RS37100	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS37140	COG0477	Major facilitator Superfamily
FNV66_RS37145	COG2226	methyltransferase
FNV66_RS37165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV66_RS37190	COG3842	ATPase activity
FNV66_RS37195	COG1176	ABC-type spermidine putrescine transport system, permease component I
FNV66_RS37200	COG1177	transmembrane transport
FNV66_RS37205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV66_RS37235	COG2508	Transcriptional regulator
FNV66_RS37235	COG2508	Transcriptional regulator
FNV66_RS37240	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS37245	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV66_RS37250	COG1653	transport
FNV66_RS37255	COG4209	transmembrane transport
FNV66_RS37260	COG0395	ABC-type sugar transport system, permease component
FNV66_RS37300	COG5297	Belongs to the glycosyl hydrolase family 6
FNV66_RS37315	COG0653	protein targeting
FNV66_RS37325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FNV66_RS37330	COG0750	zinc metalloprotease
FNV66_RS37335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FNV66_RS37350	COG0442	prolyl-tRNA aminoacylation
FNV66_RS37370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FNV66_RS37395	COG0779	Required for maturation of 30S ribosomal subunits
FNV66_RS37410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FNV66_RS37420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FNV66_RS37425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FNV66_RS37450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNV66_RS37455	COG0601	transmembrane transport
FNV66_RS37465	COG0455	bacterial-type flagellum organization
FNV66_RS37485	COG1404	Belongs to the peptidase S8 family
FNV66_RS37560	COG1674	ftsk spoiiie
FNV66_RS37575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FNV66_RS37580	COG1185	polyribonucleotide nucleotidyltransferase activity
FNV66_RS37585	COG0612	Peptidase, M16
FNV66_RS37590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FNV66_RS37610	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FNV66_RS37615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV66_RS37620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FNV66_RS37650	COG2208	phosphoserine phosphatase activity
FNV66_RS37650	COG2770	Histidine kinase
FNV66_RS37665	COG1674	ftsk spoiiie
FNV66_RS37675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FNV66_RS37685	COG1058	Belongs to the CinA family
FNV66_RS37685	COG1546	Belongs to the CinA family
FNV66_RS37690	COG1396	sequence-specific DNA binding
FNV66_RS37695	COG0783	Belongs to the Dps family
FNV66_RS37700	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS37705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FNV66_RS37710	COG1201	RNA secondary structure unwinding
FNV66_RS37740	COG0628	permease
FNV66_RS37750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FNV66_RS37770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FNV66_RS37780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV66_RS37785	COG0765	amino acid transport
FNV66_RS37790	COG0765	amino acid transport
FNV66_RS37795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV66_RS37800	COG1126	abc transporter atp-binding protein
FNV66_RS37805	COG0745	RESPONSE REGULATOR receiver
FNV66_RS37810	COG2205	protein histidine kinase activity
FNV66_RS37840	COG2197	response regulator
FNV66_RS37870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FNV66_RS37890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FNV66_RS37900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FNV66_RS37905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FNV66_RS37915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FNV66_RS37955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FNV66_RS37960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FNV66_RS37965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FNV66_RS37980	COG0588	phosphoglycerate mutase activity
FNV66_RS38000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FNV66_RS38040	COG1802	Transcriptional regulator
FNV66_RS38045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FNV66_RS38060	COG0187	DNA topoisomerase II activity
FNV66_RS38075	COG2197	response regulator
FNV66_RS38085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV66_RS38090	COG4565	transcriptional regulatory protein
FNV66_RS38100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV66_RS38110	COG4565	transcriptional regulatory protein
FNV66_RS38115	COG3290	protein histidine kinase activity
FNV66_RS38130	COG0372	Belongs to the citrate synthase family
FNV66_RS38150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FNV66_RS38155	COG0612	Peptidase, M16
FNV66_RS38170	COG1802	Transcriptional regulator
FNV66_RS38175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNV66_RS38180	COG0045	succinate-CoA ligase (ADP-forming) activity
FNV66_RS38180	COG1042	CoA-binding domain protein
FNV66_RS38180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV66_RS38195	COG1435	thymidine kinase activity
FNV66_RS38245	COG0745	RESPONSE REGULATOR receiver
FNV66_RS38250	COG2205	protein histidine kinase activity
FNV66_RS38275	COG0756	dUTP diphosphatase activity
FNV66_RS38290	COG1136	(ABC) transporter
FNV66_RS38320	COG0569	domain protein
FNV66_RS38325	COG0531	amino acid
FNV66_RS38330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FNV66_RS38360	COG2255	four-way junction helicase activity
FNV66_RS38390	COG4585	Histidine kinase
FNV66_RS38395	COG2409	Drug exporters of the RND superfamily
FNV66_RS38410	COG0243	molybdopterin cofactor binding
FNV66_RS38415	COG1799	cell septum assembly
FNV66_RS38445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FNV66_RS38460	COG2235	arginine
FNV66_RS38465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FNV66_RS38470	COG0531	amino acid
FNV66_RS38480	COG1024	Enoyl-CoA hydratase
FNV66_RS38520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FNV66_RS38540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FNV66_RS38550	COG1404	Belongs to the peptidase S8 family
FNV66_RS38555	COG0745	RESPONSE REGULATOR receiver
FNV66_RS38560	COG2205	protein histidine kinase activity
FNV66_RS38575	COG3537	Alpha-1,2-mannosidase
FNV66_RS38585	COG1653	transport
FNV66_RS38590	COG1175	transmembrane transport
FNV66_RS38595	COG0395	ABC-type sugar transport system, permease component
FNV66_RS38600	COG1940	carbohydrate kinase activity
FNV66_RS38605	COG4213	ABC transporter substrate-binding protein
FNV66_RS38615	COG4214	carbohydrate transport
FNV66_RS38620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FNV66_RS38625	COG0531	amino acid
FNV66_RS38645	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV66_RS38645	COG1024	Enoyl-CoA hydratase
FNV66_RS38650	COG0183	Belongs to the thiolase family
FNV66_RS38655	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FNV66_RS38670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FNV66_RS38685	COG0446	pyridine nucleotide-disulphide oxidoreductase
FNV66_RS38720	COG3220	belongs to the UPF0276 family
FNV66_RS38755	COG2326	polyphosphate kinase activity
FNV66_RS38760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FNV66_RS38800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FNV66_RS38805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FNV66_RS38815	COG0515	serine threonine protein kinase
FNV66_RS38860	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
FNV66_RS38900	COG2205	protein histidine kinase activity
FNV66_RS38900	COG4999	Histidine kinase
FNV66_RS38900	COG3850	Histidine kinase
FNV66_RS38900	COG3437	response regulator, receiver
FNV66_RS38925	COG0154	amidase activity
FNV66_RS38940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV66_RS38970	COG0642	Histidine kinase
FNV66_RS39065	COG0504	CTP synthase activity
FNV66_RS39080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FNV66_RS39200	COG0667	Aldo Keto reductase
FNV66_RS39205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FNV66_RS39225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV66_RS39230	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FNV66_RS39255	COG0529	Catalyzes the synthesis of activated sulfate
FNV66_RS39260	COG0175	sulfate reduction
FNV66_RS39290	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS39305	COG4977	sequence-specific DNA binding
FNV66_RS39305	COG1917	Cupin 2, conserved barrel domain protein
FNV66_RS39335	COG1609	Transcriptional regulator
FNV66_RS39365	COG0154	amidase activity
FNV66_RS39375	COG2040	homocysteine
FNV66_RS39435	COG0596	Alpha beta hydrolase
FNV66_RS39530	COG3903	Transcriptional regulator
FNV66_RS39530	COG3629	intracellular signal transduction
FNV66_RS39545	COG0702	epimerase
FNV66_RS39635	COG1131	(ABC) transporter
FNV66_RS39655	COG1175	transmembrane transport
FNV66_RS39670	COG0277	FAD linked oxidase domain protein
FNV66_RS39750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FNV66_RS39760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FNV66_RS39770	COG1162	GTPase activity
FNV66_RS39815	COG0028	Belongs to the TPP enzyme family
FNV66_RS39835	COG1802	Transcriptional regulator
FNV66_RS39865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV66_RS39870	COG2252	PERMEase
FNV66_RS39900	COG0726	polysaccharide deacetylase
FNV66_RS39905	COG0673	inositol 2-dehydrogenase activity
FNV66_RS39915	COG1132	(ABC) transporter
FNV66_RS39925	COG0596	Alpha beta hydrolase
FNV66_RS39930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV66_RS39950	COG1477	protein flavinylation
FNV66_RS39965	COG0745	RESPONSE REGULATOR receiver
FNV66_RS39970	COG2205	protein histidine kinase activity
FNV66_RS40000	COG3629	intracellular signal transduction
FNV66_RS40000	COG3903	Transcriptional regulator
FNV66_RS40010	COG4977	sequence-specific DNA binding
FNV66_RS40045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FNV66_RS40060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FNV66_RS40065	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FNV66_RS40070	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FNV66_RS40135	COG0673	inositol 2-dehydrogenase activity
FNV66_RS40140	COG0667	Aldo Keto reductase
FNV66_RS40180	COG2267	carboxylic ester hydrolase activity
FNV66_RS40190	COG0598	Magnesium transport protein CorA
FNV66_RS40205	COG0583	DNA-binding transcription factor activity
FNV66_RS40225	COG2197	response regulator
FNV66_RS40230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV66_RS40235	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS40245	COG3960	tartronate-semialdehyde synthase activity
FNV66_RS40255	COG0753	catalase activity
FNV66_RS40260	COG2084	Dehydrogenase
FNV66_RS40265	COG3622	Belongs to the hyi family
FNV66_RS40285	COG2351	hydroxyisourate hydrolase activity
FNV66_RS40300	COG2233	PERMEase
FNV66_RS40315	COG1733	regulation of RNA biosynthetic process
FNV66_RS40330	COG0406	alpha-ribazole phosphatase activity
FNV66_RS40335	COG0436	Aminotransferase
FNV66_RS40355	COG2304	oxidoreductase activity
FNV66_RS40360	COG4264	IucA IucC family
FNV66_RS40370	COG2815	serine threonine protein kinase
FNV66_RS40370	COG0515	serine threonine protein kinase
FNV66_RS40395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FNV66_RS40405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV66_RS40420	COG1414	Transcriptional regulator
FNV66_RS40425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FNV66_RS40430	COG4266	Belongs to the allantoicase family
FNV66_RS40435	COG0598	Magnesium transport protein CorA
FNV66_RS40450	COG0667	Aldo Keto reductase
FNV66_RS40455	COG2197	response regulator
FNV66_RS40465	COG0673	inositol 2-dehydrogenase activity
FNV66_RS40470	COG2188	Transcriptional regulator
FNV66_RS40495	COG1940	carbohydrate kinase activity
FNV66_RS40505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FNV66_RS40515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS40520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FNV66_RS40535	COG1126	abc transporter atp-binding protein
FNV66_RS40545	COG0765	amino acid transport
FNV66_RS40550	COG0765	amino acid transport
FNV66_RS40565	COG0405	Gamma-glutamyltransferase
FNV66_RS40605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FNV66_RS40615	COG1953	Uracil, thiamine, allantoin
FNV66_RS40625	COG2226	methyltransferase
FNV66_RS40635	COG3851	Histidine kinase
FNV66_RS40640	COG2197	response regulator
FNV66_RS40655	COG0483	inositol monophosphate 1-phosphatase activity
FNV66_RS40670	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FNV66_RS40680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FNV66_RS40685	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FNV66_RS40695	COG1215	transferase activity, transferring glycosyl groups
FNV66_RS40705	COG4310	Domain of unknown function (DUF2172)
FNV66_RS40720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FNV66_RS40730	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS40755	COG0367	asparagine synthase
FNV66_RS40775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FNV66_RS40795	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS40800	COG0583	DNA-binding transcription factor activity
FNV66_RS40810	COG0477	Major facilitator Superfamily
FNV66_RS40825	COG1309	transcriptional regulator
FNV66_RS40860	COG0745	RESPONSE REGULATOR receiver
FNV66_RS40875	COG1136	(ABC) transporter
FNV66_RS40885	COG2205	protein histidine kinase activity
FNV66_RS40890	COG2205	protein histidine kinase activity
FNV66_RS40900	COG0671	phosphoesterase, PA-phosphatase related
FNV66_RS40920	COG0640	Transcriptional regulator
FNV66_RS40940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FNV66_RS40985	COG2130	NADP-dependent
FNV66_RS40990	COG0789	Transcriptional regulator
FNV66_RS40995	COG1192	Involved in chromosome partitioning
FNV66_RS41025	COG1929	Belongs to the glycerate kinase type-1 family
FNV66_RS41035	COG0688	phosphatidylethanolamine metabolic process
FNV66_RS41040	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS41050	COG2301	Belongs to the HpcH HpaI aldolase family
FNV66_RS41055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS41055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV66_RS41060	COG0604	alcohol dehydrogenase
FNV66_RS41075	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV66_RS41085	COG0456	acetyltransferase
FNV66_RS41085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV66_RS41095	COG0596	Alpha beta hydrolase
FNV66_RS41120	COG2226	methyltransferase
FNV66_RS41160	COG2362	D-Aminopeptidase
FNV66_RS41165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV66_RS41175	COG1619	proteins homologs of microcin C7 resistance protein MccF
FNV66_RS41205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FNV66_RS41210	COG2226	methyltransferase
FNV66_RS41220	COG0488	(ABC) transporter
FNV66_RS41310	COG0443	Heat shock 70 kDa protein
FNV66_RS41325	COG2154	pterin-4-alpha-carbinolamine dehydratase
FNV66_RS41330	COG2226	methyltransferase
FNV66_RS41345	COG2378	regulation of single-species biofilm formation
FNV66_RS41350	COG3401	FG-GAP repeat protein
FNV66_RS41360	COG5297	Belongs to the glycosyl hydrolase family 6
FNV66_RS41360	COG4733	cellulase activity
FNV66_RS41370	COG5297	Belongs to the glycosyl hydrolase family 6
FNV66_RS41390	COG2319	Wd-40 repeat
FNV66_RS41390	COG4249	Peptidase C14 caspase catalytic subunit p20
FNV66_RS41395	COG4221	oxidoreductase activity
FNV66_RS41405	COG0656	L-ascorbic acid biosynthetic process
FNV66_RS41430	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FNV66_RS41440	COG3469	chitinase activity
FNV66_RS41445	COG3250	beta-galactosidase activity
FNV66_RS41455	COG0477	Major facilitator Superfamily
FNV66_RS41490	COG1846	Transcriptional regulator
FNV66_RS41495	COG1335	isochorismatase
FNV66_RS41505	COG0583	DNA-binding transcription factor activity
FNV66_RS41510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FNV66_RS41525	COG3383	formate dehydrogenase (NAD+) activity
FNV66_RS41530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FNV66_RS41545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV66_RS41555	COG1940	carbohydrate kinase activity
FNV66_RS41560	COG1129	ABC transporter
FNV66_RS41565	COG1172	Belongs to the binding-protein-dependent transport system permease family
FNV66_RS41570	COG1879	ABC-type sugar transport system periplasmic component
FNV66_RS41575	COG0673	inositol 2-dehydrogenase activity
FNV66_RS41585	COG3507	Belongs to the glycosyl hydrolase 43 family
FNV66_RS41600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FNV66_RS41615	COG0084	hydrolase, TatD family'
FNV66_RS41640	COG2223	nitrite transmembrane transporter activity
FNV66_RS41650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV66_RS41660	COG0045	succinate-CoA ligase (ADP-forming) activity
FNV66_RS41670	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS41705	COG5002	protein histidine kinase activity
FNV66_RS41705	COG0784	Response regulator, receiver
FNV66_RS41730	COG0789	Transcriptional regulator
FNV66_RS41765	COG0402	S-adenosylhomocysteine deaminase activity
FNV66_RS41795	COG2226	methyltransferase
FNV66_RS41810	COG4044	May play a role in the intracellular transport of hydrophobic ligands
FNV66_RS41820	COG4221	oxidoreductase activity
FNV66_RS41840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FNV66_RS41845	COG0254	rRNA binding
FNV66_RS41855	COG4585	Histidine kinase
FNV66_RS41860	COG2197	response regulator
FNV66_RS41890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS41895	COG2072	flavoprotein involved in K transport
FNV66_RS41915	COG0022	dehydrogenase e1 component
FNV66_RS41920	COG1309	transcriptional regulator
FNV66_RS41925	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS41930	COG1063	alcohol dehydrogenase
FNV66_RS41945	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS41950	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS41955	COG0745	RESPONSE REGULATOR receiver
FNV66_RS42010	COG0542	response to heat
FNV66_RS42040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV66_RS42050	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
FNV66_RS42065	COG1063	alcohol dehydrogenase
FNV66_RS42075	COG0745	RESPONSE REGULATOR receiver
FNV66_RS42085	COG0477	Major facilitator Superfamily
FNV66_RS42090	COG2124	cytochrome p450
FNV66_RS42110	COG0477	Major facilitator Superfamily
FNV66_RS42145	COG2353	YceI-like domain
FNV66_RS42155	COG0765	amino acid transport
FNV66_RS42175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS42180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS42185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS42190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS42205	COG0596	Alpha beta hydrolase
FNV66_RS42205	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV66_RS42215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FNV66_RS42240	COG0438	transferase activity, transferring glycosyl groups
FNV66_RS42255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FNV66_RS42285	COG0477	Major facilitator Superfamily
FNV66_RS42295	COG3467	pyridoxamine 5'-phosphate
FNV66_RS42310	COG0477	Major facilitator Superfamily
FNV66_RS42320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FNV66_RS42340	COG0588	phosphoglycerate mutase activity
FNV66_RS42345	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FNV66_RS42350	COG0166	Belongs to the GPI family
FNV66_RS42365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FNV66_RS42400	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS42425	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FNV66_RS42430	COG3250	beta-galactosidase activity
FNV66_RS42435	COG0395	ABC-type sugar transport system, permease component
FNV66_RS42440	COG1175	transmembrane transport
FNV66_RS42450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV66_RS42455	COG1349	DNA-binding transcription factor activity
FNV66_RS42460	COG1486	melibiose metabolic process
FNV66_RS42470	COG3469	chitinase activity
FNV66_RS42535	COG3842	ATPase activity
FNV66_RS42540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FNV66_RS42545	COG1176	ABC-type spermidine putrescine transport system, permease component I
FNV66_RS42550	COG1177	transmembrane transport
FNV66_RS42635	COG1181	Belongs to the D-alanine--D-alanine ligase family
FNV66_RS42640	COG2258	MOSC domain
FNV66_RS42645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV66_RS42645	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FNV66_RS42665	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FNV66_RS42675	COG1181	Belongs to the D-alanine--D-alanine ligase family
FNV66_RS42700	COG2175	clavaminate synthase activity
FNV66_RS42730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNV66_RS42745	COG1770	oligopeptidase
FNV66_RS42750	COG2423	ornithine cyclodeaminase activity
FNV66_RS42755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FNV66_RS42855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV66_RS42860	COG3938	Belongs to the proline racemase family
FNV66_RS42880	COG1175	transmembrane transport
FNV66_RS42885	COG0395	ABC-type sugar transport system, permease component
FNV66_RS42890	COG0366	Alpha amylase catalytic
FNV66_RS42900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV66_RS42905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV66_RS43015	COG3511	phospholipase C
FNV66_RS43045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FNV66_RS43050	COG0477	Major facilitator Superfamily
FNV66_RS43060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS43070	COG3485	protocatechuate 3,4-dioxygenase
FNV66_RS43075	COG3485	protocatechuate 3,4-dioxygenase
FNV66_RS43080	COG0183	Belongs to the thiolase family
FNV66_RS43095	COG1846	Transcriptional regulator
FNV66_RS43105	COG0714	Associated with various cellular activities
FNV66_RS43120	COG1793	dna ligase
FNV66_RS43125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FNV66_RS43195	COG1834	amidinotransferase
FNV66_RS43200	COG0488	(ABC) transporter
FNV66_RS43210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FNV66_RS43230	COG1515	deoxyribonuclease V activity
FNV66_RS43240	COG3268	Saccharopine dehydrogenase
FNV66_RS43245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV66_RS43250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS43255	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS43260	COG0183	Belongs to the thiolase family
FNV66_RS43265	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV66_RS43265	COG1024	Enoyl-CoA hydratase
FNV66_RS43270	COG0789	Transcriptional regulator
FNV66_RS43275	COG1113	amino acid transport
FNV66_RS43285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FNV66_RS43295	COG2936	dipeptidyl-peptidase activity
FNV66_RS43310	COG0488	(ABC) transporter
FNV66_RS43320	COG2183	response to ionizing radiation
FNV66_RS43330	COG4977	sequence-specific DNA binding
FNV66_RS43340	COG1024	Enoyl-CoA hydratase
FNV66_RS43355	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FNV66_RS43360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FNV66_RS43360	COG4106	trans-aconitate 2-methyltransferase activity
FNV66_RS43405	COG1134	teichoic acid transport
FNV66_RS43410	COG1562	ergosterol biosynthetic process
FNV66_RS43420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FNV66_RS43430	COG1657	PFAM Prenyltransferase squalene oxidase
FNV66_RS43445	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FNV66_RS43450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FNV66_RS43470	COG2365	Tyrosine phosphatase family
FNV66_RS43485	COG3401	FG-GAP repeat protein
FNV66_RS43495	COG2755	lipolytic protein G-D-S-L family
FNV66_RS43510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FNV66_RS43550	COG1063	alcohol dehydrogenase
FNV66_RS43555	COG0156	8-amino-7-oxononanoate synthase activity
FNV66_RS43560	COG0583	DNA-binding transcription factor activity
FNV66_RS43595	COG3958	Transketolase
FNV66_RS43600	COG3959	Transketolase, thiamine diphosphate binding domain
FNV66_RS43620	COG1132	(ABC) transporter
FNV66_RS43650	COG3033	Beta-eliminating lyase
FNV66_RS43670	COG1937	Protein conserved in bacteria
FNV66_RS43690	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FNV66_RS43710	COG3239	Fatty acid desaturase
FNV66_RS43720	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FNV66_RS43815	COG3485	protocatechuate 3,4-dioxygenase
FNV66_RS43820	COG1454	alcohol dehydrogenase
FNV66_RS43830	COG0351	phosphomethylpyrimidine kinase
FNV66_RS43835	COG0702	epimerase
FNV66_RS43885	COG1595	DNA-templated transcription, initiation
FNV66_RS43895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FNV66_RS43905	COG1053	succinate dehydrogenase
FNV66_RS43910	COG1764	response to oxidative stress
FNV66_RS43915	COG1595	DNA-templated transcription, initiation
FNV66_RS43970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV66_RS43995	COG2838	Isocitrate dehydrogenase
FNV66_RS44000	COG0668	transmembrane transport
FNV66_RS44005	COG1024	Enoyl-CoA hydratase
FNV66_RS44020	COG2409	Drug exporters of the RND superfamily
FNV66_RS44025	COG1309	transcriptional regulator
FNV66_RS44030	COG0473	3-isopropylmalate dehydrogenase activity
FNV66_RS44040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV66_RS44055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV66_RS44070	COG3483	tryptophan 2,3-dioxygenase activity
FNV66_RS44085	COG0475	glutathione-regulated potassium exporter activity
FNV66_RS44090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FNV66_RS44105	COG2264	protein methyltransferase activity
FNV66_RS44135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FNV66_RS44150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNV66_RS44155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FNV66_RS44160	COG0697	spore germination
FNV66_RS44165	COG1509	lysine 2,3-aminomutase activity
FNV66_RS44175	COG0579	oxidoreductase
FNV66_RS44225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FNV66_RS44240	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FNV66_RS44260	COG0297	glycogen (starch) synthase activity
FNV66_RS44265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FNV66_RS44285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV66_RS44290	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS44300	COG0701	Predicted permease
FNV66_RS44335	COG1609	Transcriptional regulator
FNV66_RS44345	COG1175	transmembrane transport
FNV66_RS44350	COG0395	ABC-type sugar transport system, permease component
FNV66_RS44370	COG2186	Transcriptional regulator
FNV66_RS44380	COG1129	ABC transporter
FNV66_RS44390	COG4948	Mandelate Racemase Muconate Lactonizing
FNV66_RS44395	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS44430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FNV66_RS44465	COG0726	polysaccharide deacetylase
FNV66_RS44510	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS44515	COG0583	DNA-binding transcription factor activity
FNV66_RS44525	COG1053	succinate dehydrogenase
FNV66_RS44530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FNV66_RS44550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS44570	COG0667	Aldo Keto reductase
FNV66_RS44605	COG1595	DNA-templated transcription, initiation
FNV66_RS44645	COG2814	Major facilitator Superfamily
FNV66_RS44650	COG0583	DNA-binding transcription factor activity
FNV66_RS44655	COG0583	DNA-binding transcription factor activity
FNV66_RS44670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV66_RS44675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FNV66_RS44680	COG2080	2 iron, 2 sulfur cluster binding
FNV66_RS44695	COG0667	Aldo Keto reductase
FNV66_RS44725	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FNV66_RS44730	COG0121	glutamine amidotransferase
FNV66_RS44735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FNV66_RS44740	COG3572	ergothioneine biosynthetic process
FNV66_RS44755	COG2268	Band 7 protein
FNV66_RS44770	COG1609	Transcriptional regulator
FNV66_RS44785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FNV66_RS44795	COG0242	peptide deformylase activity
FNV66_RS44880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV66_RS44895	COG1408	metallophosphoesterase
FNV66_RS44900	COG2226	methyltransferase
FNV66_RS44940	COG2378	regulation of single-species biofilm formation
FNV66_RS44965	COG1609	Transcriptional regulator
FNV66_RS44980	COG0395	ABC-type sugar transport system, permease component
FNV66_RS45035	COG1309	transcriptional regulator
FNV66_RS45040	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS45070	COG0163	prenyltransferase activity
FNV66_RS45105	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FNV66_RS45125	COG2318	DinB family
FNV66_RS45145	COG1733	regulation of RNA biosynthetic process
FNV66_RS45155	COG2366	antibiotic biosynthetic process
FNV66_RS45160	COG1073	alpha beta
FNV66_RS45210	COG0583	DNA-binding transcription factor activity
FNV66_RS45215	COG2130	NADP-dependent
FNV66_RS45240	COG2072	flavoprotein involved in K transport
FNV66_RS45245	COG0667	Aldo Keto reductase
FNV66_RS45250	COG1902	pentaerythritol trinitrate reductase activity
FNV66_RS45270	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS45285	COG0183	Belongs to the thiolase family
FNV66_RS45305	COG3485	protocatechuate 3,4-dioxygenase
FNV66_RS45315	COG2909	trisaccharide binding
FNV66_RS45340	COG0778	Nitroreductase
FNV66_RS45390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FNV66_RS45400	COG3537	Alpha-1,2-mannosidase
FNV66_RS45425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS45445	COG0477	Major facilitator Superfamily
FNV66_RS45465	COG0006	proline dipeptidase activity
FNV66_RS45470	COG3291	Pkd domain containing protein
FNV66_RS45480	COG0673	inositol 2-dehydrogenase activity
FNV66_RS45490	COG1609	Transcriptional regulator
FNV66_RS45495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV66_RS45530	COG1122	ATPase activity
FNV66_RS45535	COG1122	ATPase activity
FNV66_RS45540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FNV66_RS45565	COG0561	phosphatase activity
FNV66_RS45640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FNV66_RS45645	COG2151	metal-sulfur cluster biosynthetic enzyme
FNV66_RS45650	COG3396	Phenylacetate-CoA oxygenase
FNV66_RS45655	COG3460	Phenylacetate-CoA oxygenase
FNV66_RS45660	COG3396	Phenylacetate-CoA oxygenase
FNV66_RS45665	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV66_RS45685	COG2050	protein possibly involved in aromatic compounds catabolism
FNV66_RS45700	COG0531	amino acid
FNV66_RS45770	COG2226	methyltransferase
FNV66_RS45800	COG1024	Enoyl-CoA hydratase
FNV66_RS45800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FNV66_RS45810	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FNV66_RS45840	COG0375	protein maturation
FNV66_RS45845	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FNV66_RS45850	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FNV66_RS45855	COG0298	carbon dioxide binding
FNV66_RS45860	COG0409	Hydrogenase expression formation protein
FNV66_RS45865	COG0309	Hydrogenase expression formation protein (HypE)
FNV66_RS45895	COG1141	Ferredoxin
FNV66_RS45925	COG1136	(ABC) transporter
FNV66_RS45930	COG1174	glycine betaine transport
FNV66_RS45935	COG1174	glycine betaine transport
FNV66_RS45960	COG1556	Lactate utilization protein
FNV66_RS45965	COG1139	Iron-sulfur cluster binding protein
FNV66_RS45970	COG0247	lactate metabolic process
FNV66_RS45975	COG1070	Carbohydrate kinase
FNV66_RS45980	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS45980	COG3347	Dehydrogenase
FNV66_RS45990	COG1129	ABC transporter
FNV66_RS46020	COG1609	Transcriptional regulator
FNV66_RS46030	COG1595	DNA-templated transcription, initiation
FNV66_RS46035	COG1357	PFAM Pentapeptide repeats (8 copies)
FNV66_RS46045	COG1309	transcriptional regulator
FNV66_RS46055	COG2706	6-phosphogluconolactonase activity
FNV66_RS46080	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS46080	COG3321	synthase
FNV66_RS46080	COG0604	alcohol dehydrogenase
FNV66_RS46105	COG2723	6-phospho-beta-galactosidase activity
FNV66_RS46110	COG0395	ABC-type sugar transport system, permease component
FNV66_RS46115	COG1175	transmembrane transport
FNV66_RS46120	COG2182	Extracellular solute-binding protein
FNV66_RS46145	COG2267	carboxylic ester hydrolase activity
FNV66_RS46155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FNV66_RS46155	COG1796	DNA polymerase
FNV66_RS46205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FNV66_RS46230	COG0515	serine threonine protein kinase
FNV66_RS46275	COG0640	Transcriptional regulator
FNV66_RS46280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FNV66_RS46285	COG0772	Belongs to the SEDS family
FNV66_RS46315	COG1316	TRANSCRIPTIONal
FNV66_RS46325	COG1278	Cold shock
FNV66_RS46360	COG0515	serine threonine protein kinase
FNV66_RS46370	COG1132	(ABC) transporter
FNV66_RS46380	COG2197	response regulator
FNV66_RS46390	COG0531	amino acid
FNV66_RS46510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV66_RS46510	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FNV66_RS46530	COG1609	Transcriptional regulator
FNV66_RS46560	COG1621	beta-fructofuranosidase activity
FNV66_RS46685	COG0789	Transcriptional regulator
FNV66_RS46705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FNV66_RS46830	COG0745	RESPONSE REGULATOR receiver
FNV66_RS46880	COG2132	Multicopper oxidase
FNV66_RS46900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FNV66_RS46920	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS46960	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS46970	COG0531	amino acid
FNV66_RS47010	COG2124	cytochrome p450
FNV66_RS47050	COG0596	Alpha beta hydrolase
FNV66_RS47055	COG1672	PFAM Archaeal ATPase
FNV66_RS47055	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FNV66_RS47085	COG3250	beta-galactosidase activity
FNV66_RS47090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FNV66_RS47115	COG0640	Transcriptional regulator
FNV66_RS47150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FNV66_RS47180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS47195	COG4209	transmembrane transport
FNV66_RS47200	COG0395	ABC-type sugar transport system, permease component
FNV66_RS47210	COG1609	Transcriptional regulator
FNV66_RS47225	COG0671	phosphoesterase, PA-phosphatase related
FNV66_RS47240	COG3832	glyoxalase III activity
FNV66_RS47285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FNV66_RS47285	COG2755	lipolytic protein G-D-S-L family
FNV66_RS47300	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FNV66_RS47350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FNV66_RS47365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FNV66_RS47380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FNV66_RS47405	COG1132	(ABC) transporter
FNV66_RS47455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV66_RS47460	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS47490	COG1846	Transcriptional regulator
FNV66_RS47490	COG1940	carbohydrate kinase activity
FNV66_RS47510	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FNV66_RS47535	COG1595	DNA-templated transcription, initiation
FNV66_RS47580	COG4948	Mandelate Racemase Muconate Lactonizing
FNV66_RS47590	COG0583	DNA-binding transcription factor activity
FNV66_RS47635	COG1404	Belongs to the peptidase S8 family
FNV66_RS47655	COG2318	DinB family
FNV66_RS47685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FNV66_RS47690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV66_RS47695	COG2409	Drug exporters of the RND superfamily
FNV66_RS47730	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS47735	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS47795	COG1802	Transcriptional regulator
FNV66_RS47855	COG0384	phenazine biosynthesis protein PhzF
FNV66_RS47865	COG0583	DNA-binding transcription factor activity
FNV66_RS47885	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS47920	COG1278	Cold shock
FNV66_RS47945	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FNV66_RS47990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV66_RS48000	COG0596	Alpha beta hydrolase
FNV66_RS48015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FNV66_RS48030	COG1940	carbohydrate kinase activity
FNV66_RS48040	COG1175	transmembrane transport
FNV66_RS48045	COG0395	ABC-type sugar transport system, permease component
FNV66_RS48075	COG2340	Cysteine-rich secretory protein family
FNV66_RS48120	COG3469	chitinase activity
FNV66_RS48130	COG3548	integral membrane protein
FNV66_RS48140	COG0667	Aldo Keto reductase
FNV66_RS48150	COG3537	Alpha-1,2-mannosidase
FNV66_RS48175	COG1129	ABC transporter
FNV66_RS48195	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS48200	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS48205	COG1024	Enoyl-CoA hydratase
FNV66_RS48215	COG0183	Belongs to the thiolase family
FNV66_RS48220	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS48230	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS48235	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS48240	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS48245	COG1024	Enoyl-CoA hydratase
FNV66_RS48275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV66_RS48290	COG1228	amidohydrolase
FNV66_RS48295	COG0515	serine threonine protein kinase
FNV66_RS48305	COG3250	beta-galactosidase activity
FNV66_RS48330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FNV66_RS48335	COG0730	response to heat
FNV66_RS48340	COG1937	Protein conserved in bacteria
FNV66_RS48380	COG1175	transmembrane transport
FNV66_RS48405	COG3345	alpha-galactosidase
FNV66_RS48415	COG0667	Aldo Keto reductase
FNV66_RS48420	COG1335	isochorismatase
FNV66_RS48440	COG3852	Histidine kinase
FNV66_RS48475	COG3290	protein histidine kinase activity
FNV66_RS48485	COG2814	Major facilitator Superfamily
FNV66_RS48510	COG0842	Transport permease protein
FNV66_RS48510	COG1716	ATPase activity
FNV66_RS48510	COG1131	(ABC) transporter
FNV66_RS48545	COG0739	heme binding
FNV66_RS48565	COG0583	DNA-binding transcription factor activity
FNV66_RS48570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FNV66_RS48585	COG2197	response regulator
FNV66_RS48605	COG0395	ABC-type sugar transport system, permease component
FNV66_RS48620	COG1335	isochorismatase
FNV66_RS48635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FNV66_RS48650	COG5002	protein histidine kinase activity
FNV66_RS48665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV66_RS48670	COG1053	succinate dehydrogenase
FNV66_RS48680	COG2318	DinB family
FNV66_RS48690	COG2318	DinB family
FNV66_RS48730	COG0596	Alpha beta hydrolase
FNV66_RS48735	COG1017	nitric oxide dioxygenase activity
FNV66_RS48735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FNV66_RS48765	COG1595	DNA-templated transcription, initiation
FNV66_RS48785	COG0745	RESPONSE REGULATOR receiver
FNV66_RS48805	COG1309	transcriptional regulator
FNV66_RS48815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FNV66_RS48825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV66_RS48825	COG2080	2 iron, 2 sulfur cluster binding
FNV66_RS48850	COG2197	response regulator
FNV66_RS48875	COG4191	Histidine kinase
FNV66_RS48885	COG0516	GMP reductase activity
FNV66_RS48885	COG0517	IMP dehydrogenase activity
FNV66_RS48930	COG2326	polyphosphate kinase activity
FNV66_RS48935	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FNV66_RS48940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FNV66_RS48960	COG1042	CoA-binding domain protein
FNV66_RS48960	COG0045	succinate-CoA ligase (ADP-forming) activity
FNV66_RS48960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV66_RS48965	COG0516	GMP reductase activity
FNV66_RS48965	COG0517	IMP dehydrogenase activity
FNV66_RS48985	COG0516	GMP reductase activity
FNV66_RS48985	COG0517	IMP dehydrogenase activity
FNV66_RS49000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FNV66_RS49000	COG0574	Belongs to the PEP-utilizing enzyme family
FNV66_RS49025	COG0517	IMP dehydrogenase activity
FNV66_RS49025	COG0516	GMP reductase activity
FNV66_RS49035	COG0516	GMP reductase activity
FNV66_RS49035	COG0517	IMP dehydrogenase activity
FNV66_RS49050	COG2239	Acts as a magnesium transporter
FNV66_RS49105	COG1063	alcohol dehydrogenase
FNV66_RS49120	COG0531	amino acid
FNV66_RS49125	COG2235	arginine
FNV66_RS49130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FNV66_RS49135	COG0549	Belongs to the carbamate kinase family
FNV66_RS49145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FNV66_RS49170	COG1309	transcriptional regulator
FNV66_RS49175	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS49190	COG1278	Cold shock
FNV66_RS49195	COG0513	Belongs to the DEAD box helicase family
FNV66_RS49245	COG1132	(ABC) transporter
FNV66_RS49290	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FNV66_RS49295	COG2226	methyltransferase
FNV66_RS49300	COG5640	endopeptidase activity
FNV66_RS49315	COG0789	Transcriptional regulator
FNV66_RS49345	COG1132	(ABC) transporter
FNV66_RS49360	COG2318	DinB family
FNV66_RS49380	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS49385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FNV66_RS49390	COG1414	Transcriptional regulator
FNV66_RS49405	COG4106	trans-aconitate 2-methyltransferase activity
FNV66_RS49435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS49440	COG1335	isochorismatase
FNV66_RS49455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV66_RS49520	COG2208	phosphoserine phosphatase activity
FNV66_RS49535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV66_RS49570	COG0583	DNA-binding transcription factor activity
FNV66_RS49575	COG0243	molybdopterin cofactor binding
FNV66_RS49610	COG2837	iron assimilation
FNV66_RS49620	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS49635	COG2207	Transcriptional regulator
FNV66_RS49645	COG0745	RESPONSE REGULATOR receiver
FNV66_RS49650	COG2205	protein histidine kinase activity
FNV66_RS49670	COG0640	Transcriptional regulator
FNV66_RS49750	COG1309	transcriptional regulator
FNV66_RS49760	COG1309	transcriptional regulator
FNV66_RS49765	COG1064	alcohol dehydrogenase
FNV66_RS49780	COG1172	Belongs to the binding-protein-dependent transport system permease family
FNV66_RS49785	COG1129	ABC transporter
FNV66_RS49795	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS49850	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS49855	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS49880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV66_RS49895	COG1522	sequence-specific DNA binding
FNV66_RS49940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS49965	COG1595	DNA-templated transcription, initiation
FNV66_RS49995	COG2267	carboxylic ester hydrolase activity
FNV66_RS50010	COG0531	amino acid
FNV66_RS50025	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS50030	COG4221	oxidoreductase activity
FNV66_RS50055	COG4941	Belongs to the sigma-70 factor family
FNV66_RS50060	COG3795	YCII-related domain
FNV66_RS50110	COG1309	transcriptional regulator
FNV66_RS50115	COG0667	Aldo Keto reductase
FNV66_RS50145	COG2124	cytochrome p450
FNV66_RS50170	COG2197	response regulator
FNV66_RS50200	COG2197	response regulator
FNV66_RS50205	COG4585	Histidine kinase
FNV66_RS50210	COG4552	Acetyltransferase involved in intracellular survival and related
FNV66_RS50250	COG0596	Alpha beta hydrolase
FNV66_RS50270	COG2197	response regulator
FNV66_RS50285	COG0446	pyridine nucleotide-disulphide oxidoreductase
FNV66_RS50285	COG1902	pentaerythritol trinitrate reductase activity
FNV66_RS50290	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS50295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FNV66_RS50305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV66_RS50325	COG0583	DNA-binding transcription factor activity
FNV66_RS50330	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS50350	COG0745	RESPONSE REGULATOR receiver
FNV66_RS50440	COG1309	transcriptional regulator
FNV66_RS50450	COG1309	transcriptional regulator
FNV66_RS50510	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS50520	COG0596	Alpha beta hydrolase
FNV66_RS50530	COG0604	alcohol dehydrogenase
FNV66_RS50580	COG0326	Molecular chaperone. Has ATPase activity
FNV66_RS50590	COG2409	Drug exporters of the RND superfamily
FNV66_RS50600	COG2072	flavoprotein involved in K transport
FNV66_RS50605	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS50610	COG1012	belongs to the aldehyde dehydrogenase family
FNV66_RS50630	COG4974	Belongs to the 'phage' integrase family
FNV66_RS50680	COG4977	sequence-specific DNA binding
FNV66_RS50700	COG1024	Enoyl-CoA hydratase
FNV66_RS50755	COG0446	pyridine nucleotide-disulphide oxidoreductase
FNV66_RS50755	COG1902	pentaerythritol trinitrate reductase activity
FNV66_RS50785	COG4221	oxidoreductase activity
FNV66_RS50795	COG0477	Major facilitator Superfamily
FNV66_RS50810	COG0477	Major facilitator Superfamily
FNV66_RS50815	COG0477	Major facilitator Superfamily
FNV66_RS50835	COG1609	Transcriptional regulator
FNV66_RS50865	COG0667	Aldo Keto reductase
FNV66_RS50880	COG0300	oxidoreductase activity
FNV66_RS50915	COG1802	Transcriptional regulator
FNV66_RS50920	COG2205	protein histidine kinase activity
FNV66_RS50925	COG0745	RESPONSE REGULATOR receiver
FNV66_RS50930	COG2409	Drug exporters of the RND superfamily
FNV66_RS51050	COG2261	transglycosylase associated protein
FNV66_RS51055	COG0640	Transcriptional regulator
FNV66_RS51060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FNV66_RS51075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FNV66_RS51120	COG0179	Fumarylacetoacetate (FAA) hydrolase
FNV66_RS51135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV66_RS51160	COG0202	RNA polymerase activity
FNV66_RS51175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV66_RS51255	COG4977	sequence-specific DNA binding
FNV66_RS51270	COG0477	Major facilitator Superfamily
FNV66_RS51365	COG2770	Histidine kinase
FNV66_RS51365	COG2208	phosphoserine phosphatase activity
FNV66_RS51405	COG2272	Belongs to the type-B carboxylesterase lipase family
FNV66_RS51415	COG2197	response regulator
FNV66_RS51485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV66_RS51530	COG4221	oxidoreductase activity
FNV66_RS51530	COG3321	synthase
FNV66_RS51530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV66_RS51530	COG0604	alcohol dehydrogenase
FNV66_RS51540	COG3328	transposase activity
FNV66_RS51565	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS51625	COG4585	Histidine kinase
FNV66_RS51650	COG2135	peptidase activity
FNV66_RS51725	COG1309	transcriptional regulator
FNV66_RS51805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FNV66_RS51815	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FNV66_RS51865	COG2192	nodulation
FNV66_RS51885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV66_RS51890	COG0483	inositol monophosphate 1-phosphatase activity
FNV66_RS51895	COG0583	DNA-binding transcription factor activity
FNV66_RS51945	COG0563	adenylate kinase activity
FNV66_RS51985	COG2159	amidohydrolase
FNV66_RS52000	COG2226	methyltransferase
FNV66_RS52005	COG3328	transposase activity
FNV66_RS52040	COG2197	response regulator
FNV66_RS52085	COG1674	ftsk spoiiie
FNV66_RS52135	COG4584	PFAM Integrase catalytic
FNV66_RS52140	COG1484	DNA-dependent DNA replication
FNV66_RS52235	COG3385	transposase activity
FNV66_RS52305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV66_RS52325	COG3321	synthase
FNV66_RS52325	COG0300	oxidoreductase activity
FNV66_RS52325	COG4221	oxidoreductase activity
FNV66_RS52325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV66_RS52345	COG0318	PFAM AMP-dependent synthetase and ligase
FNV66_RS52350	COG2197	response regulator
FNV66_RS52380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FNV66_RS52385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV66_RS52390	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS52395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FNV66_RS52400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV66_RS52405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FNV66_RS52410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV66_RS52415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV66_RS52420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV66_RS52430	COG0667	Aldo Keto reductase
FNV66_RS52445	COG1022	Amp-dependent synthetase and ligase
FNV66_RS52470	COG0477	Major facilitator Superfamily
FNV66_RS52480	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FNV66_RS52570	COG1335	isochorismatase
FNV66_RS52575	COG3619	membrane
FNV66_RS52615	COG3547	Transposase (IS116 IS110 IS902 family)
FNV66_RS52665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FNV66_RS52760	COG3387	PFAM Glycoside hydrolase 15-related
FNV66_RS52770	COG4585	Histidine kinase
FNV66_RS52805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV66_RS52875	COG0248	Ppx GppA phosphatase
FNV66_RS52975	COG0604	alcohol dehydrogenase
FNV66_RS53055	COG4977	sequence-specific DNA binding
FNV66_RS53120	COG2207	Transcriptional regulator
FNV66_RS53135	COG2801	Transposase and inactivated derivatives
FNV66_RS53185	COG0583	DNA-binding transcription factor activity
FNV66_RS53220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FNV66_RS53260	COG1960	acyl-CoA dehydrogenase activity
FNV66_RS53265	COG1454	alcohol dehydrogenase
FNV66_RS53280	COG0583	DNA-binding transcription factor activity
FNV66_RS53285	COG0183	Belongs to the thiolase family
FNV66_RS53295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FNV66_RS53310	COG0006	proline dipeptidase activity
FNV66_RS53315	COG2084	Dehydrogenase
FNV66_RS53335	COG2188	Transcriptional regulator
FNV66_RS53345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FNV66_RS53350	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV66_RS53370	COG1609	Transcriptional regulator
FNV66_RS53395	COG1131	(ABC) transporter
FNV66_RS53420	COG1335	isochorismatase
FNV66_RS53425	COG3619	membrane
FNV66_RS53460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV66_RS53470	COG1116	anion transmembrane transporter activity
FNV66_RS53480	COG2353	YceI-like domain
FNV66_RS53485	COG1028	Short-chain dehydrogenase reductase Sdr
FNV66_RS53580	COG3328	transposase activity
FNV66_RS53585	COG3328	transposase activity
FNV66_RS53590	COG0069	glutamate synthase activity
FNV66_RS53710	COG1309	transcriptional regulator
FNV66_RS53720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FNV66_RS53805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FNV66_RS53930	COG0515	serine threonine protein kinase
FNV66_RS53930	COG2815	serine threonine protein kinase