locus-tag	class	description
N6H00_RS00140	COG1024	Enoyl-CoA hydratase
N6H00_RS00140	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS00230	COG1733	regulation of RNA biosynthetic process
N6H00_RS00235	COG0604	alcohol dehydrogenase
N6H00_RS00245	COG0640	Transcriptional regulator
N6H00_RS00280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N6H00_RS00285	COG1414	Transcriptional regulator
N6H00_RS00290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N6H00_RS00305	COG3842	ATPase activity
N6H00_RS00320	COG3328	transposase activity
N6H00_RS00325	COG2226	methyltransferase
N6H00_RS00345	COG0114	fumarate hydratase activity
N6H00_RS00365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N6H00_RS00370	COG1917	Cupin 2, conserved barrel domain protein
N6H00_RS00370	COG4977	sequence-specific DNA binding
N6H00_RS00385	COG0583	DNA-binding transcription factor activity
N6H00_RS00400	COG1414	Transcriptional regulator
N6H00_RS00425	COG2318	DinB family
N6H00_RS00440	COG0745	RESPONSE REGULATOR receiver
N6H00_RS00460	COG1309	transcriptional regulator
N6H00_RS00475	COG0477	Major facilitator Superfamily
N6H00_RS00485	COG4948	Mandelate Racemase Muconate Lactonizing
N6H00_RS00540	COG3509	depolymerase
N6H00_RS00560	COG3345	alpha-galactosidase
N6H00_RS00585	COG2843	Capsule synthesis protein
N6H00_RS00600	COG4608	Belongs to the ABC transporter superfamily
N6H00_RS00605	COG0444	Belongs to the ABC transporter superfamily
N6H00_RS00610	COG0601	transmembrane transport
N6H00_RS00650	COG1733	regulation of RNA biosynthetic process
N6H00_RS00660	COG1802	Transcriptional regulator
N6H00_RS00665	COG0179	Fumarylacetoacetate (FAA) hydrolase
N6H00_RS00670	COG0346	lactoylglutathione lyase activity
N6H00_RS00675	COG2814	Major facilitator Superfamily
N6H00_RS00680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS00690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N6H00_RS00700	COG1309	transcriptional regulator
N6H00_RS00710	COG2226	methyltransferase
N6H00_RS00730	COG0009	L-threonylcarbamoyladenylate synthase
N6H00_RS00740	COG0300	oxidoreductase activity
N6H00_RS00750	COG1309	transcriptional regulator
N6H00_RS00765	COG2130	NADP-dependent
N6H00_RS00770	COG1733	regulation of RNA biosynthetic process
N6H00_RS00775	COG0702	epimerase
N6H00_RS00800	COG0625	glutathione transferase activity
N6H00_RS00815	COG0604	alcohol dehydrogenase
N6H00_RS00835	COG1414	Transcriptional regulator
N6H00_RS00840	COG2814	Major facilitator Superfamily
N6H00_RS00845	COG0596	Alpha beta hydrolase
N6H00_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS00865	COG3485	protocatechuate 3,4-dioxygenase
N6H00_RS00870	COG1454	alcohol dehydrogenase
N6H00_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS00900	COG0730	response to heat
N6H00_RS00915	COG1937	Protein conserved in bacteria
N6H00_RS00925	COG1733	regulation of RNA biosynthetic process
N6H00_RS00930	COG0583	DNA-binding transcription factor activity
N6H00_RS00960	COG2072	flavoprotein involved in K transport
N6H00_RS00980	COG1609	Transcriptional regulator
N6H00_RS00985	COG0434	BtpA family
N6H00_RS01000	COG1129	ABC transporter
N6H00_RS01005	COG1172	Belongs to the binding-protein-dependent transport system permease family
N6H00_RS01030	COG1309	transcriptional regulator
N6H00_RS01035	COG0738	Major facilitator superfamily
N6H00_RS01040	COG3226	Transcriptional regulator
N6H00_RS01045	COG0583	DNA-binding transcription factor activity
N6H00_RS01050	COG0477	Major facilitator Superfamily
N6H00_RS01120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N6H00_RS01130	COG1902	pentaerythritol trinitrate reductase activity
N6H00_RS01155	COG1132	(ABC) transporter
N6H00_RS01160	COG0657	acetylesterase activity
N6H00_RS01195	COG0800	Aldolase
N6H00_RS01200	COG1414	Transcriptional regulator
N6H00_RS01210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N6H00_RS01215	COG4221	oxidoreductase activity
N6H00_RS01250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS01265	COG3409	Peptidoglycan-binding domain 1 protein
N6H00_RS01275	COG3903	Transcriptional regulator
N6H00_RS01275	COG3629	intracellular signal transduction
N6H00_RS01285	COG2814	Major facilitator Superfamily
N6H00_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS01305	COG0583	DNA-binding transcription factor activity
N6H00_RS01310	COG2860	membrane
N6H00_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS01330	COG0596	Alpha beta hydrolase
N6H00_RS01335	COG2207	Transcriptional regulator
N6H00_RS01350	COG4585	Histidine kinase
N6H00_RS01400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N6H00_RS01415	COG1940	carbohydrate kinase activity
N6H00_RS01420	COG3345	alpha-galactosidase
N6H00_RS01430	COG0395	ABC-type sugar transport system, permease component
N6H00_RS01435	COG1175	transmembrane transport
N6H00_RS01465	COG0667	Aldo Keto reductase
N6H00_RS01475	COG0697	spore germination
N6H00_RS01495	COG3387	PFAM Glycoside hydrolase 15-related
N6H00_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS01510	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS01530	COG0477	Major facilitator Superfamily
N6H00_RS01540	COG2197	response regulator
N6H00_RS01545	COG4585	Histidine kinase
N6H00_RS01550	COG2409	Drug exporters of the RND superfamily
N6H00_RS01565	COG1472	Belongs to the glycosyl hydrolase 3 family
N6H00_RS01600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS01620	COG3321	synthase
N6H00_RS01620	COG0604	alcohol dehydrogenase
N6H00_RS01635	COG1024	Enoyl-CoA hydratase
N6H00_RS01660	COG2186	Transcriptional regulator
N6H00_RS01665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N6H00_RS01710	COG0028	Belongs to the TPP enzyme family
N6H00_RS01715	COG2159	amidohydrolase
N6H00_RS01730	COG1116	anion transmembrane transporter activity
N6H00_RS01755	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N6H00_RS01765	COG0154	amidase activity
N6H00_RS01770	COG1309	transcriptional regulator
N6H00_RS01805	COG0596	Alpha beta hydrolase
N6H00_RS01830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N6H00_RS01865	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
N6H00_RS01905	COG4977	sequence-specific DNA binding
N6H00_RS01925	COG1846	Transcriptional regulator
N6H00_RS01935	COG2226	methyltransferase
N6H00_RS01970	COG1914	H( )-stimulated, divalent metal cation uptake system
N6H00_RS01980	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS02045	COG0583	DNA-binding transcription factor activity
N6H00_RS02055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N6H00_RS02085	COG1136	(ABC) transporter
N6H00_RS02095	COG3250	beta-galactosidase activity
N6H00_RS02145	COG1959	2 iron, 2 sulfur cluster binding
N6H00_RS02150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N6H00_RS02150	COG1017	nitric oxide dioxygenase activity
N6H00_RS02155	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N6H00_RS02160	COG2345	Transcriptional regulator
N6H00_RS02205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N6H00_RS02205	COG1796	DNA polymerase
N6H00_RS02220	COG0673	inositol 2-dehydrogenase activity
N6H00_RS02235	COG2814	Major facilitator Superfamily
N6H00_RS02250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N6H00_RS02270	COG0667	Aldo Keto reductase
N6H00_RS02285	COG3940	Belongs to the glycosyl hydrolase 43 family
N6H00_RS02305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6H00_RS02310	COG0765	amino acid transport
N6H00_RS02325	COG3458	cephalosporin-C deacetylase activity
N6H00_RS02330	COG3507	Belongs to the glycosyl hydrolase 43 family
N6H00_RS02355	COG3852	Histidine kinase
N6H00_RS02370	COG2267	carboxylic ester hydrolase activity
N6H00_RS02375	COG4829	muconolactone delta-isomerase
N6H00_RS02380	COG3485	protocatechuate 3,4-dioxygenase
N6H00_RS02390	COG0154	amidase activity
N6H00_RS02405	COG4638	Rieske (2fe-2S)
N6H00_RS02420	COG0477	Major facilitator Superfamily
N6H00_RS02425	COG1414	Transcriptional regulator
N6H00_RS02440	COG0367	asparagine synthase
N6H00_RS02445	COG1309	transcriptional regulator
N6H00_RS02480	COG1397	ADP-ribosylglycohydrolase
N6H00_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS02535	COG0673	inositol 2-dehydrogenase activity
N6H00_RS02545	COG2080	2 iron, 2 sulfur cluster binding
N6H00_RS02550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N6H00_RS02555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N6H00_RS02575	COG2391	methyltransferase activity
N6H00_RS02595	COG0477	Major facilitator Superfamily
N6H00_RS02600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS02615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6H00_RS02625	COG4172	Belongs to the ABC transporter superfamily
N6H00_RS02630	COG0596	Alpha beta hydrolase
N6H00_RS02670	COG1021	2,3-dihydroxybenzoate-AMP ligase
N6H00_RS02680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6H00_RS02695	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS02715	COG0477	Major facilitator Superfamily
N6H00_RS02730	COG0745	RESPONSE REGULATOR receiver
N6H00_RS02735	COG1132	(ABC) transporter
N6H00_RS02750	COG1132	(ABC) transporter
N6H00_RS02755	COG1132	(ABC) transporter
N6H00_RS02770	COG1946	Acyl-CoA thioesterase
N6H00_RS02780	COG2018	Roadblock/LC7 domain
N6H00_RS02825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N6H00_RS02830	COG4279	zinc finger
N6H00_RS02835	COG4677	pectinesterase activity
N6H00_RS02850	COG1940	carbohydrate kinase activity
N6H00_RS02860	COG0483	inositol monophosphate 1-phosphatase activity
N6H00_RS02865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N6H00_RS02875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N6H00_RS02880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N6H00_RS02890	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS02895	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS02905	COG3572	ergothioneine biosynthetic process
N6H00_RS02910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N6H00_RS02920	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
N6H00_RS02940	COG2814	Major facilitator Superfamily
N6H00_RS02945	COG1349	DNA-binding transcription factor activity
N6H00_RS02955	COG1940	carbohydrate kinase activity
N6H00_RS02960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N6H00_RS02995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N6H00_RS03005	COG0531	amino acid
N6H00_RS03015	COG2340	Cysteine-rich secretory protein family
N6H00_RS03025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N6H00_RS03110	COG0243	molybdopterin cofactor binding
N6H00_RS03110	COG3383	formate dehydrogenase (NAD+) activity
N6H00_RS03115	COG0437	4 iron, 4 sulfur cluster binding
N6H00_RS03140	COG3012	SEC-C Motif Domain Protein
N6H00_RS03160	COG0477	Major facilitator Superfamily
N6H00_RS03185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N6H00_RS03200	COG2080	2 iron, 2 sulfur cluster binding
N6H00_RS03205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N6H00_RS03210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N6H00_RS03215	COG1309	transcriptional regulator
N6H00_RS03225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N6H00_RS03225	COG2755	lipolytic protein G-D-S-L family
N6H00_RS03230	COG1215	transferase activity, transferring glycosyl groups
N6H00_RS03285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N6H00_RS03310	COG0604	alcohol dehydrogenase
N6H00_RS03310	COG3321	synthase
N6H00_RS03350	COG0596	Alpha beta hydrolase
N6H00_RS03350	COG2945	thiolester hydrolase activity
N6H00_RS03370	COG0604	alcohol dehydrogenase
N6H00_RS03370	COG3321	synthase
N6H00_RS03375	COG0604	alcohol dehydrogenase
N6H00_RS03375	COG3321	synthase
N6H00_RS03380	COG3321	synthase
N6H00_RS03380	COG0604	alcohol dehydrogenase
N6H00_RS03400	COG3629	intracellular signal transduction
N6H00_RS03410	COG2936	dipeptidyl-peptidase activity
N6H00_RS03415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N6H00_RS03425	COG0542	response to heat
N6H00_RS03435	COG1595	DNA-templated transcription, initiation
N6H00_RS03450	COG4171	peptide transport system, permease
N6H00_RS03455	COG0747	negative chemotaxis
N6H00_RS03485	COG2313	pseudouridylate synthase activity
N6H00_RS03490	COG1522	sequence-specific DNA binding
N6H00_RS03490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6H00_RS03525	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS03540	COG3290	protein histidine kinase activity
N6H00_RS03550	COG0673	inositol 2-dehydrogenase activity
N6H00_RS03560	COG0604	alcohol dehydrogenase
N6H00_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS03560	COG3321	synthase
N6H00_RS03575	COG1834	amidinotransferase
N6H00_RS03580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N6H00_RS03590	COG2186	Transcriptional regulator
N6H00_RS03600	COG0477	Major facilitator Superfamily
N6H00_RS03605	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N6H00_RS03620	COG0443	Heat shock 70 kDa protein
N6H00_RS03640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N6H00_RS03650	COG1522	sequence-specific DNA binding
N6H00_RS03665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS03680	COG0596	Alpha beta hydrolase
N6H00_RS03685	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS03690	COG1802	Transcriptional regulator
N6H00_RS03695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N6H00_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS03750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N6H00_RS03750	COG1796	DNA polymerase
N6H00_RS03770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N6H00_RS03775	COG1349	DNA-binding transcription factor activity
N6H00_RS03780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N6H00_RS03785	COG0191	fructose-bisphosphate aldolase activity
N6H00_RS03830	COG0745	RESPONSE REGULATOR receiver
N6H00_RS03835	COG2205	protein histidine kinase activity
N6H00_RS03840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N6H00_RS03850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N6H00_RS03865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N6H00_RS03890	COG0590	tRNA wobble adenosine to inosine editing
N6H00_RS03910	COG0183	Belongs to the thiolase family
N6H00_RS03935	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS03955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N6H00_RS03965	COG3360	Dodecin
N6H00_RS03980	COG3959	Transketolase, thiamine diphosphate binding domain
N6H00_RS03985	COG1252	NADH dehydrogenase
N6H00_RS03995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N6H00_RS04005	COG1609	Transcriptional regulator
N6H00_RS04035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N6H00_RS04055	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
N6H00_RS04070	COG0110	maltose O-acetyltransferase activity
N6H00_RS04120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS04130	COG0671	phosphoesterase, PA-phosphatase related
N6H00_RS04145	COG0477	Major facilitator Superfamily
N6H00_RS04175	COG0745	RESPONSE REGULATOR receiver
N6H00_RS04180	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS04190	COG0174	glutamine synthetase
N6H00_RS04200	COG0300	oxidoreductase activity
N6H00_RS04205	COG3537	Alpha-1,2-mannosidase
N6H00_RS04215	COG1595	DNA-templated transcription, initiation
N6H00_RS04220	COG0386	Belongs to the glutathione peroxidase family
N6H00_RS04225	COG2353	YceI-like domain
N6H00_RS04290	COG0395	ABC-type sugar transport system, permease component
N6H00_RS04295	COG1175	transmembrane transport
N6H00_RS04300	COG1653	transport
N6H00_RS04305	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N6H00_RS04305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N6H00_RS04315	COG1486	melibiose metabolic process
N6H00_RS04335	COG0395	ABC-type sugar transport system, permease component
N6H00_RS04340	COG1063	alcohol dehydrogenase
N6H00_RS04355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N6H00_RS04360	COG1914	H( )-stimulated, divalent metal cation uptake system
N6H00_RS04365	COG1349	DNA-binding transcription factor activity
N6H00_RS04375	COG0514	ATP-dependent DNA helicase (RecQ)
N6H00_RS04400	COG2186	Transcriptional regulator
N6H00_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS04445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS04455	COG0765	amino acid transport
N6H00_RS04460	COG1126	abc transporter atp-binding protein
N6H00_RS04480	COG0640	Transcriptional regulator
N6H00_RS04540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N6H00_RS04550	COG0277	FAD linked oxidase domain protein
N6H00_RS04555	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
N6H00_RS04570	COG0589	response to stress
N6H00_RS04580	COG1063	alcohol dehydrogenase
N6H00_RS04625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N6H00_RS04645	COG0242	peptide deformylase activity
N6H00_RS04670	COG3903	Transcriptional regulator
N6H00_RS04670	COG3629	intracellular signal transduction
N6H00_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS04735	COG0667	Aldo Keto reductase
N6H00_RS04740	COG4608	Belongs to the ABC transporter superfamily
N6H00_RS04750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6H00_RS04755	COG0601	transmembrane transport
N6H00_RS04760	COG0747	negative chemotaxis
N6H00_RS04765	COG3395	kinase activity
N6H00_RS04770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N6H00_RS04775	COG1349	DNA-binding transcription factor activity
N6H00_RS04790	COG1191	sigma factor activity
N6H00_RS04800	COG1793	dna ligase
N6H00_RS04830	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS04860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N6H00_RS04865	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS04875	COG0242	peptide deformylase activity
N6H00_RS04885	COG3442	glutamine amidotransferase
N6H00_RS04890	COG0205	6-phosphofructokinase activity
N6H00_RS04915	COG0829	nickel cation binding
N6H00_RS04920	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N6H00_RS04930	COG0804	urea catabolic process
N6H00_RS04935	COG0832	Belongs to the urease beta subunit family
N6H00_RS04940	COG0831	urea catabolic process
N6H00_RS04955	COG0740	serine-type endopeptidase activity
N6H00_RS04965	COG0791	NLP P60 protein
N6H00_RS04965	COG0741	lytic transglycosylase activity
N6H00_RS05000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N6H00_RS05005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N6H00_RS05010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N6H00_RS05015	COG2226	methyltransferase
N6H00_RS05020	COG1136	(ABC) transporter
N6H00_RS05020	COG0577	efflux transmembrane transporter activity
N6H00_RS05060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N6H00_RS05075	COG1940	carbohydrate kinase activity
N6H00_RS05080	COG2188	Transcriptional regulator
N6H00_RS05085	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS05110	COG0419	ATPase involved in DNA repair
N6H00_RS05110	COG0419	ATPase involved in DNA repair
N6H00_RS05110	COG0419	ATPase involved in DNA repair
N6H00_RS05115	COG0420	3'-5' exonuclease activity
N6H00_RS05130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N6H00_RS05135	COG1116	anion transmembrane transporter activity
N6H00_RS05140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N6H00_RS05145	COG1802	Transcriptional regulator
N6H00_RS05150	COG1739	Uncharacterized protein family UPF0029
N6H00_RS05195	COG0179	Fumarylacetoacetate (FAA) hydrolase
N6H00_RS05205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS05220	COG0412	Dienelactone hydrolase
N6H00_RS05245	COG1832	CoA-binding protein
N6H00_RS05320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N6H00_RS05335	COG2271	Major facilitator Superfamily
N6H00_RS05340	COG1968	undecaprenyl-diphosphatase activity
N6H00_RS05350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N6H00_RS05355	COG0531	amino acid
N6H00_RS05385	COG0542	response to heat
N6H00_RS05400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N6H00_RS05405	COG0443	Heat shock 70 kDa protein
N6H00_RS05440	COG1309	transcriptional regulator
N6H00_RS05445	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS05450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N6H00_RS05470	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS05475	COG0477	Major facilitator Superfamily
N6H00_RS05485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N6H00_RS05490	COG1309	transcriptional regulator
N6H00_RS05565	COG1222	aaa ATPase
N6H00_RS05605	COG0583	DNA-binding transcription factor activity
N6H00_RS05615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N6H00_RS05635	COG0859	PFAM glycosyl transferase family 9
N6H00_RS05640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N6H00_RS05640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N6H00_RS05645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N6H00_RS05650	COG0297	glycogen (starch) synthase activity
N6H00_RS05675	COG2192	nodulation
N6H00_RS05680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N6H00_RS05690	COG0640	Transcriptional regulator
N6H00_RS05720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N6H00_RS05730	COG0254	rRNA binding
N6H00_RS05740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N6H00_RS05745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N6H00_RS05750	COG1024	Enoyl-CoA hydratase
N6H00_RS05765	COG0723	plastoquinol--plastocyanin reductase activity
N6H00_RS05765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N6H00_RS05780	COG1366	Belongs to the anti-sigma-factor antagonist family
N6H00_RS05780	COG2208	phosphoserine phosphatase activity
N6H00_RS05780	COG2172	sigma factor antagonist activity
N6H00_RS05795	COG2186	Transcriptional regulator
N6H00_RS05805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N6H00_RS05810	COG0673	inositol 2-dehydrogenase activity
N6H00_RS05820	COG2318	DinB family
N6H00_RS05830	COG2378	regulation of single-species biofilm formation
N6H00_RS05840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N6H00_RS05870	COG0583	DNA-binding transcription factor activity
N6H00_RS05880	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
N6H00_RS05905	COG2814	Major facilitator Superfamily
N6H00_RS05940	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N6H00_RS05945	COG0583	DNA-binding transcription factor activity
N6H00_RS05965	COG2814	Major facilitator Superfamily
N6H00_RS05965	COG0477	Major facilitator Superfamily
N6H00_RS05970	COG2186	Transcriptional regulator
N6H00_RS05980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N6H00_RS05985	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS05990	COG2079	MmgE PrpD family protein
N6H00_RS06005	COG0604	alcohol dehydrogenase
N6H00_RS06005	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS06005	COG3321	synthase
N6H00_RS06035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N6H00_RS06040	COG0477	Major facilitator Superfamily
N6H00_RS06045	COG2376	Dihydroxyacetone kinase
N6H00_RS06050	COG2376	Dihydroxyacetone kinase
N6H00_RS06075	COG1695	Transcriptional regulator
N6H00_RS06080	COG0384	phenazine biosynthesis protein PhzF
N6H00_RS06105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N6H00_RS06105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N6H00_RS06115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N6H00_RS06135	COG1716	ATPase activity
N6H00_RS06155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N6H00_RS06180	COG2190	(PTS) system
N6H00_RS06185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N6H00_RS06200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N6H00_RS06205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N6H00_RS06215	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
N6H00_RS06220	COG1177	transmembrane transport
N6H00_RS06225	COG1176	ABC-type spermidine putrescine transport system, permease component I
N6H00_RS06230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N6H00_RS06235	COG3842	ATPase activity
N6H00_RS06240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N6H00_RS06245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N6H00_RS06260	COG2018	Roadblock/LC7 domain
N6H00_RS06280	COG2146	nitrite reductase [NAD(P)H] activity
N6H00_RS06300	COG4638	Rieske (2fe-2S)
N6H00_RS06335	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
N6H00_RS06355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N6H00_RS06360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N6H00_RS06365	COG1984	allophanate hydrolase subunit 2
N6H00_RS06385	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS06390	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS06455	COG1024	Enoyl-CoA hydratase
N6H00_RS06465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N6H00_RS06490	COG2070	2-Nitropropane dioxygenase
N6H00_RS06515	COG0515	serine threonine protein kinase
N6H00_RS06530	COG0659	secondary active sulfate transmembrane transporter activity
N6H00_RS06535	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS06545	COG2376	Dihydroxyacetone kinase
N6H00_RS06550	COG1461	Dihydroxyacetone kinase
N6H00_RS06555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N6H00_RS06555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N6H00_RS06555	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
N6H00_RS06560	COG0142	geranyltranstransferase activity
N6H00_RS06570	COG2124	cytochrome p450
N6H00_RS06575	COG2124	cytochrome p450
N6H00_RS06605	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
N6H00_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS06625	COG1051	belongs to the nudix hydrolase family
N6H00_RS06645	COG0463	Glycosyl transferase, family 2
N6H00_RS06690	COG0464	growth
N6H00_RS06700	COG1349	DNA-binding transcription factor activity
N6H00_RS06730	COG1940	carbohydrate kinase activity
N6H00_RS06775	COG0445	tRNA wobble uridine modification
N6H00_RS06785	COG1660	Displays ATPase and GTPase activities
N6H00_RS06825	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N6H00_RS06865	COG0584	glycerophosphoryl diester phosphodiesterase
N6H00_RS06895	COG0671	phosphoesterase, PA-phosphatase related
N6H00_RS06905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N6H00_RS06910	COG4569	acetaldehyde dehydrogenase (acetylating) activity
N6H00_RS06915	COG3971	2-oxopent-4-enoate hydratase activity
N6H00_RS06920	COG1414	Transcriptional regulator
N6H00_RS06925	COG1414	Transcriptional regulator
N6H00_RS06960	COG1234	tRNA 3'-trailer cleavage
N6H00_RS06980	COG3384	dioxygenase
N6H00_RS07015	COG0477	Major facilitator Superfamily
N6H00_RS07055	COG3384	dioxygenase
N6H00_RS07060	COG2309	aminopeptidase activity
N6H00_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS07080	COG1335	isochorismatase
N6H00_RS07085	COG4638	Rieske (2fe-2S)
N6H00_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS07105	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS07110	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS07140	COG0640	Transcriptional regulator
N6H00_RS07150	COG2814	Major facilitator Superfamily
N6H00_RS07155	COG2271	Major facilitator Superfamily
N6H00_RS07160	COG1846	Transcriptional regulator
N6H00_RS07165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N6H00_RS07170	COG1024	Enoyl-CoA hydratase
N6H00_RS07180	COG1024	Enoyl-CoA hydratase
N6H00_RS07185	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS07200	COG1309	transcriptional regulator
N6H00_RS07220	COG2233	PERMEase
N6H00_RS07225	COG0640	Transcriptional regulator
N6H00_RS07230	COG1902	pentaerythritol trinitrate reductase activity
N6H00_RS07240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N6H00_RS07260	COG2706	6-phosphogluconolactonase activity
N6H00_RS07265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N6H00_RS07270	COG2027	D-alanyl-D-alanine carboxypeptidase
N6H00_RS07275	COG1940	carbohydrate kinase activity
N6H00_RS07285	COG1175	transmembrane transport
N6H00_RS07290	COG0395	ABC-type sugar transport system, permease component
N6H00_RS07295	COG3119	arylsulfatase activity
N6H00_RS07315	COG2124	cytochrome p450
N6H00_RS07350	COG1131	(ABC) transporter
N6H00_RS07365	COG1032	radical SAM domain protein
N6H00_RS07375	COG0455	bacterial-type flagellum organization
N6H00_RS07385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N6H00_RS07390	COG1116	anion transmembrane transporter activity
N6H00_RS07400	COG0667	Aldo Keto reductase
N6H00_RS07420	COG1802	Transcriptional regulator
N6H00_RS07425	COG0583	DNA-binding transcription factor activity
N6H00_RS07430	COG4638	Rieske (2fe-2S)
N6H00_RS07445	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS07460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS07480	COG1414	Transcriptional regulator
N6H00_RS07490	COG0477	Major facilitator Superfamily
N6H00_RS07500	COG1414	Transcriptional regulator
N6H00_RS07505	COG1473	amidohydrolase
N6H00_RS07545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N6H00_RS07550	COG1120	ATPase activity
N6H00_RS07575	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS07620	COG0477	Major facilitator Superfamily
N6H00_RS07625	COG1309	transcriptional regulator
N6H00_RS07635	COG1024	Enoyl-CoA hydratase
N6H00_RS07640	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS07645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N6H00_RS07650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6H00_RS07665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N6H00_RS07670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N6H00_RS07675	COG2267	carboxylic ester hydrolase activity
N6H00_RS07680	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
N6H00_RS07690	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N6H00_RS07700	COG0667	Aldo Keto reductase
N6H00_RS07715	COG0702	epimerase
N6H00_RS07730	COG1017	nitric oxide dioxygenase activity
N6H00_RS07730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N6H00_RS07755	COG2205	protein histidine kinase activity
N6H00_RS07760	COG0745	RESPONSE REGULATOR receiver
N6H00_RS07785	COG0395	ABC-type sugar transport system, permease component
N6H00_RS07795	COG1414	Transcriptional regulator
N6H00_RS07840	COG2226	methyltransferase
N6H00_RS07860	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS07865	COG1024	Enoyl-CoA hydratase
N6H00_RS07885	COG0183	Belongs to the thiolase family
N6H00_RS07890	COG1309	transcriptional regulator
N6H00_RS07900	COG1024	Enoyl-CoA hydratase
N6H00_RS07905	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS07920	COG4221	oxidoreductase activity
N6H00_RS07935	COG1999	signal sequence binding
N6H00_RS07940	COG2197	response regulator
N6H00_RS07965	COG3629	intracellular signal transduction
N6H00_RS07970	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS07990	COG0778	Nitroreductase
N6H00_RS07995	COG0367	asparagine synthase
N6H00_RS08005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N6H00_RS08020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N6H00_RS08035	COG0446	pyridine nucleotide-disulphide oxidoreductase
N6H00_RS08035	COG1902	pentaerythritol trinitrate reductase activity
N6H00_RS08045	COG1408	metallophosphoesterase
N6H00_RS08070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N6H00_RS08095	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS08100	COG0583	DNA-binding transcription factor activity
N6H00_RS08110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS08115	COG0604	alcohol dehydrogenase
N6H00_RS08160	COG2222	sugar isomerase
N6H00_RS08165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6H00_RS08180	COG0477	Major facilitator Superfamily
N6H00_RS08230	COG1609	Transcriptional regulator
N6H00_RS08235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N6H00_RS08260	COG0366	Alpha amylase catalytic
N6H00_RS08270	COG0583	DNA-binding transcription factor activity
N6H00_RS08275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N6H00_RS08280	COG1609	Transcriptional regulator
N6H00_RS08300	COG0300	oxidoreductase activity
N6H00_RS08310	COG0477	Major facilitator Superfamily
N6H00_RS08325	COG4221	oxidoreductase activity
N6H00_RS08335	COG1959	2 iron, 2 sulfur cluster binding
N6H00_RS08355	COG1902	pentaerythritol trinitrate reductase activity
N6H00_RS08365	COG1802	Transcriptional regulator
N6H00_RS08370	COG3284	Transcriptional regulator
N6H00_RS08380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS08390	COG2814	Major facilitator Superfamily
N6H00_RS08395	COG1063	alcohol dehydrogenase
N6H00_RS08405	COG0179	Fumarylacetoacetate (FAA) hydrolase
N6H00_RS08420	COG0179	Fumarylacetoacetate (FAA) hydrolase
N6H00_RS08435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS08445	COG0183	Belongs to the thiolase family
N6H00_RS08460	COG4221	oxidoreductase activity
N6H00_RS08500	COG0596	Alpha beta hydrolase
N6H00_RS08505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N6H00_RS08535	COG3693	PFAM glycoside hydrolase, family 10
N6H00_RS08665	COG1595	DNA-templated transcription, initiation
N6H00_RS08740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N6H00_RS08740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N6H00_RS08775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N6H00_RS08785	COG2267	carboxylic ester hydrolase activity
N6H00_RS08790	COG1228	amidohydrolase
N6H00_RS08805	COG4175	Glycine betaine
N6H00_RS08805	COG0517	IMP dehydrogenase activity
N6H00_RS08810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N6H00_RS08835	COG0805	protein transport
N6H00_RS08840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N6H00_RS08860	COG2378	regulation of single-species biofilm formation
N6H00_RS08870	COG0545	Peptidyl-prolyl cis-trans isomerase
N6H00_RS08875	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N6H00_RS08890	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N6H00_RS08895	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N6H00_RS08910	COG4122	O-methyltransferase activity
N6H00_RS08915	COG1222	aaa ATPase
N6H00_RS08935	COG0517	IMP dehydrogenase activity
N6H00_RS08935	COG1994	Peptidase M50
N6H00_RS08945	COG2197	response regulator
N6H00_RS08960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N6H00_RS08965	COG1410	methionine synthase
N6H00_RS08965	COG0646	methionine synthase
N6H00_RS08970	COG1414	Transcriptional regulator
N6H00_RS08975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N6H00_RS08980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N6H00_RS08985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N6H00_RS09000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6H00_RS09010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS09015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS09025	COG2186	Transcriptional regulator
N6H00_RS09040	COG4211	Belongs to the binding-protein-dependent transport system permease family
N6H00_RS09045	COG1129	ABC transporter
N6H00_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS09060	COG4948	Mandelate Racemase Muconate Lactonizing
N6H00_RS09070	COG0215	cysteine-tRNA ligase activity
N6H00_RS09085	COG0406	alpha-ribazole phosphatase activity
N6H00_RS09090	COG0598	Magnesium transport protein CorA
N6H00_RS09100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS09105	COG0667	Aldo Keto reductase
N6H00_RS09155	COG0189	ligase activity
N6H00_RS09170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N6H00_RS09175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N6H00_RS09180	COG3959	Transketolase, thiamine diphosphate binding domain
N6H00_RS09185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N6H00_RS09205	COG3903	Transcriptional regulator
N6H00_RS09205	COG3629	intracellular signal transduction
N6H00_RS09225	COG2080	2 iron, 2 sulfur cluster binding
N6H00_RS09230	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N6H00_RS09235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N6H00_RS09245	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS09275	COG0300	oxidoreductase activity
N6H00_RS09280	COG3573	Dehydrogenase
N6H00_RS09290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N6H00_RS09295	COG2149	membrane
N6H00_RS09325	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS09375	COG2851	Citrate transporter
N6H00_RS09380	COG0243	molybdopterin cofactor binding
N6H00_RS09385	COG1309	transcriptional regulator
N6H00_RS09390	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N6H00_RS09395	COG2188	Transcriptional regulator
N6H00_RS09420	COG1834	amidinotransferase
N6H00_RS09425	COG1725	Transcriptional regulator
N6H00_RS09440	COG2226	methyltransferase
N6H00_RS09480	COG0019	diaminopimelate decarboxylase activity
N6H00_RS09510	COG1846	Transcriptional regulator
N6H00_RS09515	COG1764	response to oxidative stress
N6H00_RS09520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N6H00_RS09525	COG0587	DNA-directed DNA polymerase activity
N6H00_RS09540	COG0330	HflC and HflK could
N6H00_RS09555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS09560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6H00_RS09565	COG1126	abc transporter atp-binding protein
N6H00_RS09585	COG1799	cell septum assembly
N6H00_RS09590	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS09595	COG0477	Major facilitator Superfamily
N6H00_RS09605	COG0671	phosphoesterase, PA-phosphatase related
N6H00_RS09655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N6H00_RS09665	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS09680	COG1160	GTP binding
N6H00_RS09690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N6H00_RS09705	COG1187	pseudouridine synthase activity
N6H00_RS09710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N6H00_RS09715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N6H00_RS09730	COG0686	Belongs to the AlaDH PNT family
N6H00_RS09740	COG0494	nUDIX hydrolase
N6H00_RS09745	COG0504	CTP synthase activity
N6H00_RS09750	COG3387	PFAM Glycoside hydrolase 15-related
N6H00_RS09760	COG0297	glycogen (starch) synthase activity
N6H00_RS09765	COG0497	DNA recombination
N6H00_RS09770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N6H00_RS09790	COG1120	ATPase activity
N6H00_RS09795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N6H00_RS09800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N6H00_RS09805	COG0647	UMP catabolic process
N6H00_RS09840	COG2094	Belongs to the DNA glycosylase MPG family
N6H00_RS09855	COG1881	PFAM PEBP family protein
N6H00_RS09875	COG1119	ATPase activity
N6H00_RS09890	COG2197	response regulator
N6H00_RS09900	COG3953	SLT domain
N6H00_RS09900	COG5280	Phage tail tape measure protein TP901
N6H00_RS09905	COG0842	Transport permease protein
N6H00_RS09905	COG1131	(ABC) transporter
N6H00_RS09905	COG1716	ATPase activity
N6H00_RS09910	COG3830	Belongs to the UPF0237 family
N6H00_RS09910	COG0560	Phosphoserine phosphatase
N6H00_RS09930	COG2807	transmembrane transport
N6H00_RS09935	COG2186	Transcriptional regulator
N6H00_RS09945	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N6H00_RS09950	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS10050	COG3479	Phenolic acid decarboxylase
N6H00_RS10070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N6H00_RS10090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N6H00_RS10095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N6H00_RS10125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N6H00_RS10140	COG3387	PFAM Glycoside hydrolase 15-related
N6H00_RS10185	COG2205	protein histidine kinase activity
N6H00_RS10185	COG3850	Histidine kinase
N6H00_RS10185	COG4999	Histidine kinase
N6H00_RS10185	COG3437	response regulator, receiver
N6H00_RS10195	COG1024	Enoyl-CoA hydratase
N6H00_RS10205	COG0488	(ABC) transporter
N6H00_RS10220	COG0235	Class ii aldolase
N6H00_RS10235	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
N6H00_RS10240	COG1492	cobalamin metabolic process
N6H00_RS10255	COG1797	cobyrinic acid a,c-diamide synthase activity
N6H00_RS10295	COG0456	acetyltransferase
N6H00_RS10305	COG1917	Cupin 2, conserved barrel domain protein
N6H00_RS10310	COG5285	phytanoyl-CoA dioxygenase
N6H00_RS10325	COG1414	Transcriptional regulator
N6H00_RS10330	COG0667	Aldo Keto reductase
N6H00_RS10345	COG3866	Pectate lyase
N6H00_RS10350	COG2755	lipolytic protein G-D-S-L family
N6H00_RS10370	COG0395	ABC-type sugar transport system, permease component
N6H00_RS10385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N6H00_RS10390	COG1802	Transcriptional regulator
N6H00_RS10400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N6H00_RS10405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N6H00_RS10410	COG1335	isochorismatase
N6H00_RS10415	COG0477	Major facilitator Superfamily
N6H00_RS10420	COG1846	Transcriptional regulator
N6H00_RS10465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS10485	COG2171	N-acyltransferase activity
N6H00_RS10500	COG3226	Transcriptional regulator
N6H00_RS10505	COG2076	Multidrug Resistance protein
N6H00_RS10515	COG0822	iron-sulfur transferase activity
N6H00_RS10520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N6H00_RS10525	COG0396	ATPase activity
N6H00_RS10535	COG0719	Fe-S assembly protein
N6H00_RS10560	COG1612	heme a metabolic process
N6H00_RS10575	COG0109	protoheme IX farnesyltransferase activity
N6H00_RS10585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N6H00_RS10600	COG0363	glucosamine-6-phosphate deaminase activity
N6H00_RS10605	COG0166	Belongs to the GPI family
N6H00_RS10620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N6H00_RS10625	COG0149	triose-phosphate isomerase activity
N6H00_RS10630	COG0126	phosphoglycerate kinase activity
N6H00_RS10635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N6H00_RS10640	COG1481	regulation of sporulation
N6H00_RS10650	COG1660	Displays ATPase and GTPase activities
N6H00_RS10655	COG0322	excinuclease ABC activity
N6H00_RS10665	COG1609	Transcriptional regulator
N6H00_RS10675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N6H00_RS10685	COG0477	Major facilitator Superfamily
N6H00_RS10705	COG0556	nucleotide-excision repair
N6H00_RS10710	COG0584	glycerophosphoryl diester phosphodiesterase
N6H00_RS10715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N6H00_RS10770	COG0237	dephospho-CoA kinase activity
N6H00_RS10785	COG0539	negative regulation of cytoplasmic translation
N6H00_RS10795	COG1643	Atp-dependent helicase
N6H00_RS10825	COG2050	protein possibly involved in aromatic compounds catabolism
N6H00_RS10845	COG0411	ABC transporter
N6H00_RS10880	COG0737	Belongs to the 5'-nucleotidase family
N6H00_RS10885	COG2814	Major facilitator Superfamily
N6H00_RS10890	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS10900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N6H00_RS10905	COG0066	3-isopropylmalate dehydratase activity
N6H00_RS10940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
N6H00_RS10945	COG1140	nitrate reductase beta subunit
N6H00_RS10965	COG0287	Prephenate dehydrogenase
N6H00_RS10965	COG1605	Chorismate mutase
N6H00_RS10985	COG3467	pyridoxamine 5'-phosphate
N6H00_RS10995	COG0070	glutamate synthase
N6H00_RS10995	COG0069	glutamate synthase activity
N6H00_RS10995	COG0067	glutamate synthase
N6H00_RS11005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N6H00_RS11015	COG0159	tryptophan synthase activity
N6H00_RS11020	COG0133	tryptophan synthase activity
N6H00_RS11025	COG0134	indole-3-glycerol-phosphate synthase activity
N6H00_RS11050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N6H00_RS11070	COG4221	oxidoreductase activity
N6H00_RS11090	COG0107	imidazoleglycerol-phosphate synthase activity
N6H00_RS11095	COG0251	oxidation-reduction process
N6H00_RS11100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N6H00_RS11105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N6H00_RS11115	COG0131	Imidazoleglycerol-phosphate dehydratase
N6H00_RS11120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N6H00_RS11125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N6H00_RS11135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N6H00_RS11140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N6H00_RS11160	COG1432	Conserved Protein
N6H00_RS11170	COG0587	DNA-directed DNA polymerase activity
N6H00_RS11215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N6H00_RS11225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N6H00_RS11240	COG1799	cell septum assembly
N6H00_RS11250	COG1496	oxidoreductase activity
N6H00_RS11255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N6H00_RS11260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N6H00_RS11265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N6H00_RS11275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N6H00_RS11280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N6H00_RS11290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N6H00_RS11305	COG0275	rRNA processing
N6H00_RS11315	COG0714	Associated with various cellular activities
N6H00_RS11345	COG1309	transcriptional regulator
N6H00_RS11350	COG1233	COG1233 Phytoene dehydrogenase and related
N6H00_RS11365	COG0352	thiamine-phosphate diphosphorylase activity
N6H00_RS11375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N6H00_RS11380	COG2022	thiamine diphosphate biosynthetic process
N6H00_RS11380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N6H00_RS11390	COG2022	thiamine diphosphate biosynthetic process
N6H00_RS11400	COG0515	serine threonine protein kinase
N6H00_RS11400	COG2815	serine threonine protein kinase
N6H00_RS11405	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N6H00_RS11410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N6H00_RS11415	COG2193	ferroxidase activity
N6H00_RS11420	COG0243	molybdopterin cofactor binding
N6H00_RS11425	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N6H00_RS11440	COG0205	6-phosphofructokinase activity
N6H00_RS11475	COG1940	carbohydrate kinase activity
N6H00_RS11485	COG0003	Pfam Anion-transporting ATPase
N6H00_RS11545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N6H00_RS11550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N6H00_RS11555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N6H00_RS11560	COG0723	plastoquinol--plastocyanin reductase activity
N6H00_RS11565	COG2010	Cytochrome c
N6H00_RS11570	COG1845	cytochrome c oxidase, subunit III
N6H00_RS11580	COG1376	ErfK ybiS ycfS ynhG family protein
N6H00_RS11590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N6H00_RS11595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N6H00_RS11605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6H00_RS11625	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N6H00_RS11630	COG2197	response regulator
N6H00_RS11635	COG4585	Histidine kinase
N6H00_RS11670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N6H00_RS11675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N6H00_RS11680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N6H00_RS11685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N6H00_RS11690	COG0508	dehydrogenase complex catalyzes the overall conversion of
N6H00_RS11700	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N6H00_RS11710	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS11735	COG0321	lipoyl(octanoyl) transferase activity
N6H00_RS11740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N6H00_RS11760	COG0174	glutamine synthetase
N6H00_RS11780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N6H00_RS11790	COG0604	alcohol dehydrogenase
N6H00_RS11815	COG0477	Major facilitator Superfamily
N6H00_RS11830	COG4566	intracellular signal transduction
N6H00_RS11845	COG0745	RESPONSE REGULATOR receiver
N6H00_RS11870	COG2197	response regulator
N6H00_RS11900	COG3833	ABC-type maltose transport systems, permease component
N6H00_RS11910	COG2182	Extracellular solute-binding protein
N6H00_RS11915	COG0366	Alpha amylase catalytic
N6H00_RS11920	COG1609	Transcriptional regulator
N6H00_RS11930	COG0561	phosphatase activity
N6H00_RS11970	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N6H00_RS11975	COG0174	glutamine synthetase
N6H00_RS11980	COG2132	Multicopper oxidase
N6H00_RS11985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N6H00_RS11985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N6H00_RS11990	COG2814	Major facilitator Superfamily
N6H00_RS12000	COG1309	transcriptional regulator
N6H00_RS12005	COG0477	Major facilitator Superfamily
N6H00_RS12010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N6H00_RS12030	COG1994	Peptidase M50
N6H00_RS12050	COG1175	transmembrane transport
N6H00_RS12105	COG2837	iron assimilation
N6H00_RS12110	COG0672	)-iron permease
N6H00_RS12140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N6H00_RS12145	COG2814	Major facilitator Superfamily
N6H00_RS12155	COG3540	Alkaline phosphatase
N6H00_RS12185	COG0071	Belongs to the small heat shock protein (HSP20) family
N6H00_RS12200	COG0583	DNA-binding transcription factor activity
N6H00_RS12205	COG0473	3-isopropylmalate dehydrogenase activity
N6H00_RS12235	COG3022	response to hydroperoxide
N6H00_RS12240	COG0800	Aldolase
N6H00_RS12255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N6H00_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS12275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N6H00_RS12280	COG2030	dehydratase
N6H00_RS12285	COG4585	Histidine kinase
N6H00_RS12290	COG2197	response regulator
N6H00_RS12305	COG3510	cephalosporin hydroxylase
N6H00_RS12310	COG0860	N-Acetylmuramoyl-L-alanine amidase
N6H00_RS12320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS12340	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS12345	COG1309	transcriptional regulator
N6H00_RS12350	COG2197	response regulator
N6H00_RS12400	COG3845	ABC transporter
N6H00_RS12415	COG0183	Belongs to the thiolase family
N6H00_RS12420	COG2124	cytochrome p450
N6H00_RS12435	COG2207	Transcriptional regulator
N6H00_RS12470	COG1024	Enoyl-CoA hydratase
N6H00_RS12500	COG0745	RESPONSE REGULATOR receiver
N6H00_RS12505	COG5002	protein histidine kinase activity
N6H00_RS12535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N6H00_RS12545	COG1396	sequence-specific DNA binding
N6H00_RS12620	COG1396	sequence-specific DNA binding
N6H00_RS12625	COG0740	serine-type endopeptidase activity
N6H00_RS12630	COG0740	serine-type endopeptidase activity
N6H00_RS12640	COG1309	transcriptional regulator
N6H00_RS12645	COG1309	transcriptional regulator
N6H00_RS12655	COG0154	amidase activity
N6H00_RS12670	COG1309	transcriptional regulator
N6H00_RS12685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N6H00_RS12810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N6H00_RS12820	COG0477	Major facilitator Superfamily
N6H00_RS12825	COG1309	transcriptional regulator
N6H00_RS12840	COG4585	Histidine kinase
N6H00_RS12845	COG2197	response regulator
N6H00_RS12850	COG0667	Aldo Keto reductase
N6H00_RS12855	COG0789	Transcriptional regulator
N6H00_RS12880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N6H00_RS12885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N6H00_RS12890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6H00_RS12935	COG4948	Mandelate Racemase Muconate Lactonizing
N6H00_RS12955	COG1129	ABC transporter
N6H00_RS12960	COG4214	carbohydrate transport
N6H00_RS13015	COG2130	NADP-dependent
N6H00_RS13035	COG1414	Transcriptional regulator
N6H00_RS13050	COG0406	alpha-ribazole phosphatase activity
N6H00_RS13055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N6H00_RS13065	COG0110	maltose O-acetyltransferase activity
N6H00_RS13080	COG2318	DinB family
N6H00_RS13085	COG0667	Aldo Keto reductase
N6H00_RS13100	COG0477	Major facilitator Superfamily
N6H00_RS13105	COG0129	dihydroxy-acid dehydratase activity
N6H00_RS13110	COG1053	succinate dehydrogenase
N6H00_RS13110	COG3976	FMN-binding domain protein
N6H00_RS13125	COG0251	oxidation-reduction process
N6H00_RS13160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N6H00_RS13165	COG1024	Enoyl-CoA hydratase
N6H00_RS13170	COG0583	DNA-binding transcription factor activity
N6H00_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS13190	COG0583	DNA-binding transcription factor activity
N6H00_RS13235	COG1070	Carbohydrate kinase
N6H00_RS13240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N6H00_RS13245	COG0358	DNA primase activity
N6H00_RS13255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N6H00_RS13265	COG0243	molybdopterin cofactor binding
N6H00_RS13270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N6H00_RS13280	COG2949	membrane
N6H00_RS13325	COG2124	cytochrome p450
N6H00_RS13330	COG2124	cytochrome p450
N6H00_RS13335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N6H00_RS13340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N6H00_RS13340	COG2146	nitrite reductase [NAD(P)H] activity
N6H00_RS13345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N6H00_RS13345	COG2146	nitrite reductase [NAD(P)H] activity
N6H00_RS13355	COG1609	Transcriptional regulator
N6H00_RS13360	COG1653	transport
N6H00_RS13365	COG1175	transmembrane transport
N6H00_RS13375	COG1472	Belongs to the glycosyl hydrolase 3 family
N6H00_RS13390	COG0300	oxidoreductase activity
N6H00_RS13405	COG2890	protein-(glutamine-N5) methyltransferase activity
N6H00_RS13410	COG1846	Transcriptional regulator
N6H00_RS13415	COG3485	protocatechuate 3,4-dioxygenase
N6H00_RS13420	COG3485	protocatechuate 3,4-dioxygenase
N6H00_RS13425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N6H00_RS13430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N6H00_RS13435	COG2182	Extracellular solute-binding protein
N6H00_RS13440	COG1175	transmembrane transport
N6H00_RS13445	COG0395	ABC-type sugar transport system, permease component
N6H00_RS13450	COG2188	Transcriptional regulator
N6H00_RS13455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N6H00_RS13460	COG0531	amino acid
N6H00_RS13470	COG0574	Belongs to the PEP-utilizing enzyme family
N6H00_RS13470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N6H00_RS13475	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
N6H00_RS13520	COG0477	Major facilitator Superfamily
N6H00_RS13535	COG0423	glycine-tRNA ligase activity
N6H00_RS13545	COG1121	(ABC) transporter
N6H00_RS13550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N6H00_RS13625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N6H00_RS13630	COG1381	Involved in DNA repair and RecF pathway recombination
N6H00_RS13695	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS13735	COG1404	Belongs to the peptidase S8 family
N6H00_RS13770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N6H00_RS13795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N6H00_RS13815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N6H00_RS13825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6H00_RS13830	COG1234	tRNA 3'-trailer cleavage
N6H00_RS13835	COG0537	adenosine 5'-monophosphoramidase activity
N6H00_RS13845	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS13870	COG0484	heat shock protein binding
N6H00_RS13875	COG1420	regulation of RNA biosynthetic process
N6H00_RS13900	COG1022	Amp-dependent synthetase and ligase
N6H00_RS13905	COG0481	GTPase activity
N6H00_RS13910	COG0268	Binds directly to 16S ribosomal RNA
N6H00_RS13930	COG4122	O-methyltransferase activity
N6H00_RS13945	COG1307	EDD domain protein, DegV family
N6H00_RS13955	COG0495	leucyl-tRNA aminoacylation
N6H00_RS13980	COG0588	phosphoglycerate mutase activity
N6H00_RS13985	COG0799	negative regulation of ribosome biogenesis
N6H00_RS13995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N6H00_RS14010	COG0501	Belongs to the peptidase M48B family
N6H00_RS14025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N6H00_RS14035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N6H00_RS14045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N6H00_RS14050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N6H00_RS14055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N6H00_RS14060	COG1530	ribonuclease E activity
N6H00_RS14080	COG0772	Belongs to the SEDS family
N6H00_RS14085	COG0768	penicillin binding
N6H00_RS14100	COG1077	Cell shape determining protein MreB Mrl
N6H00_RS14105	COG0105	UTP biosynthetic process
N6H00_RS14115	COG0285	dihydrofolate synthase activity
N6H00_RS14120	COG0768	penicillin binding
N6H00_RS14125	COG0525	valine-tRNA ligase activity
N6H00_RS14145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N6H00_RS14150	COG0740	serine-type endopeptidase activity
N6H00_RS14155	COG0740	serine-type endopeptidase activity
N6H00_RS14160	COG0544	peptidyl-prolyl cis-trans isomerase activity
N6H00_RS14180	COG3594	Acyltransferase
N6H00_RS14190	COG4552	Acetyltransferase involved in intracellular survival and related
N6H00_RS14205	COG1113	amino acid transport
N6H00_RS14210	COG1268	BioY protein
N6H00_RS14215	COG1113	amino acid transport
N6H00_RS14220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N6H00_RS14225	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N6H00_RS14285	COG0668	transmembrane transport
N6H00_RS14295	COG1846	Transcriptional regulator
N6H00_RS14295	COG1940	carbohydrate kinase activity
N6H00_RS14300	COG1653	transport
N6H00_RS14305	COG1175	transmembrane transport
N6H00_RS14310	COG0395	ABC-type sugar transport system, permease component
N6H00_RS14315	COG1486	melibiose metabolic process
N6H00_RS14330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6H00_RS14360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N6H00_RS14390	COG0629	single-stranded DNA binding
N6H00_RS14395	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N6H00_RS14410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N6H00_RS14445	COG0142	geranyltranstransferase activity
N6H00_RS14455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N6H00_RS14460	COG1993	acr, cog1993
N6H00_RS14465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N6H00_RS14470	COG0583	DNA-binding transcription factor activity
N6H00_RS14490	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS14515	COG3321	synthase
N6H00_RS14515	COG0604	alcohol dehydrogenase
N6H00_RS14520	COG3321	synthase
N6H00_RS14520	COG0604	alcohol dehydrogenase
N6H00_RS14530	COG3321	synthase
N6H00_RS14530	COG0604	alcohol dehydrogenase
N6H00_RS14550	COG3321	synthase
N6H00_RS14550	COG0604	alcohol dehydrogenase
N6H00_RS14565	COG3402	PFAM membrane-flanked domain
N6H00_RS14575	COG4585	Histidine kinase
N6H00_RS14580	COG2197	response regulator
N6H00_RS14610	COG3962	Belongs to the TPP enzyme family
N6H00_RS14615	COG3718	enzyme involved in inositol metabolism
N6H00_RS14625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6H00_RS14635	COG0673	inositol 2-dehydrogenase activity
N6H00_RS14660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N6H00_RS14665	COG1609	Transcriptional regulator
N6H00_RS14670	COG1129	ABC transporter
N6H00_RS14675	COG1879	ABC-type sugar transport system periplasmic component
N6H00_RS14680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6H00_RS14720	COG0673	inositol 2-dehydrogenase activity
N6H00_RS14735	COG0395	ABC-type sugar transport system, permease component
N6H00_RS14740	COG1175	transmembrane transport
N6H00_RS14745	COG1653	transport
N6H00_RS14765	COG1609	Transcriptional regulator
N6H00_RS14770	COG0456	acetyltransferase
N6H00_RS14770	COG1846	Transcriptional regulator
N6H00_RS14800	COG2249	NAD(P)H dehydrogenase (quinone) activity
N6H00_RS14815	COG1472	Belongs to the glycosyl hydrolase 3 family
N6H00_RS14835	COG2197	response regulator
N6H00_RS14840	COG4585	Histidine kinase
N6H00_RS14870	COG0640	Transcriptional regulator
N6H00_RS14875	COG2197	response regulator
N6H00_RS14890	COG1946	Acyl-CoA thioesterase
N6H00_RS14900	COG1309	transcriptional regulator
N6H00_RS14905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N6H00_RS14920	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS14935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N6H00_RS14940	COG0589	response to stress
N6H00_RS14950	COG4977	sequence-specific DNA binding
N6H00_RS14955	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N6H00_RS15010	COG0789	Transcriptional regulator
N6H00_RS15030	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS15030	COG2030	dehydratase
N6H00_RS15045	COG4733	cellulase activity
N6H00_RS15045	COG5297	Belongs to the glycosyl hydrolase family 6
N6H00_RS15055	COG5297	Belongs to the glycosyl hydrolase family 6
N6H00_RS15085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N6H00_RS15125	COG0406	alpha-ribazole phosphatase activity
N6H00_RS15205	COG4585	Histidine kinase
N6H00_RS15210	COG2197	response regulator
N6H00_RS15225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS15245	COG3473	Maleate cis-trans isomerase
N6H00_RS15260	COG0154	amidase activity
N6H00_RS15270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6H00_RS15275	COG0765	amino acid transport
N6H00_RS15280	COG0765	amino acid transport
N6H00_RS15285	COG1126	abc transporter atp-binding protein
N6H00_RS15320	COG4770	biotin carboxylase activity
N6H00_RS15335	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS15340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N6H00_RS15345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N6H00_RS15350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N6H00_RS15355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N6H00_RS15380	COG0300	oxidoreductase activity
N6H00_RS15405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6H00_RS15410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6H00_RS15415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N6H00_RS15425	COG0477	Major facilitator Superfamily
N6H00_RS15430	COG1063	alcohol dehydrogenase
N6H00_RS15435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N6H00_RS15440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N6H00_RS15475	COG3397	chitin binding
N6H00_RS15505	COG2186	Transcriptional regulator
N6H00_RS15550	COG0673	inositol 2-dehydrogenase activity
N6H00_RS15555	COG4702	Belongs to the UPF0303 family
N6H00_RS15565	COG0706	membrane insertase activity
N6H00_RS15575	COG3764	Sortase (surface protein transpeptidase)
N6H00_RS15580	COG2733	membrane
N6H00_RS15610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N6H00_RS15615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N6H00_RS15645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N6H00_RS15655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N6H00_RS15660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N6H00_RS15665	COG1263	PTS System
N6H00_RS15670	COG1234	tRNA 3'-trailer cleavage
N6H00_RS15690	COG1113	amino acid transport
N6H00_RS15700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N6H00_RS15710	COG1335	isochorismatase
N6H00_RS15760	COG2814	Major facilitator Superfamily
N6H00_RS15765	COG1309	transcriptional regulator
N6H00_RS15775	COG1064	alcohol dehydrogenase
N6H00_RS15780	COG0277	FAD linked oxidase domain protein
N6H00_RS15790	COG3185	4-Hydroxyphenylpyruvate dioxygenase
N6H00_RS15815	COG3480	Lon protease (S16) C-terminal proteolytic domain
N6H00_RS15830	COG3654	unkown
N6H00_RS15845	COG2855	membrane
N6H00_RS15855	COG0583	DNA-binding transcription factor activity
N6H00_RS15915	COG1674	ftsk spoiiie
N6H00_RS15955	COG0546	phosphoglycolate phosphatase activity
N6H00_RS15960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N6H00_RS15965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N6H00_RS15980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
N6H00_RS15985	COG0395	ABC-type sugar transport system, permease component
N6H00_RS16010	COG1678	Uncharacterized ACR, COG1678
N6H00_RS16015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N6H00_RS16020	COG0776	regulation of translation
N6H00_RS16030	COG1278	Cold shock
N6H00_RS16035	COG3973	AAA domain
N6H00_RS16060	COG2223	nitrite transmembrane transporter activity
N6H00_RS16075	COG0583	DNA-binding transcription factor activity
N6H00_RS16090	COG0583	DNA-binding transcription factor activity
N6H00_RS16105	COG0395	ABC-type sugar transport system, permease component
N6H00_RS16110	COG1501	Belongs to the glycosyl hydrolase 31 family
N6H00_RS16115	COG2027	D-alanyl-D-alanine carboxypeptidase
N6H00_RS16130	COG0604	alcohol dehydrogenase
N6H00_RS16160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N6H00_RS16165	COG1051	belongs to the nudix hydrolase family
N6H00_RS16175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N6H00_RS16180	COG0793	Belongs to the peptidase S41A family
N6H00_RS16190	COG2884	Cell division ATP-binding protein ftsE
N6H00_RS16205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N6H00_RS16210	COG0515	serine threonine protein kinase
N6H00_RS16215	COG0515	serine threonine protein kinase
N6H00_RS16220	COG1674	ftsk spoiiie
N6H00_RS16225	COG1653	transport
N6H00_RS16230	COG1175	transmembrane transport
N6H00_RS16235	COG0395	ABC-type sugar transport system, permease component
N6H00_RS16280	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS16305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
N6H00_RS16310	COG2902	Dehydrogenase
N6H00_RS16315	COG0693	protein deglycase activity
N6H00_RS16335	COG0653	protein targeting
N6H00_RS16345	COG3214	Protein conserved in bacteria
N6H00_RS16350	COG2197	response regulator
N6H00_RS16355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N6H00_RS16365	COG3842	ATPase activity
N6H00_RS16390	COG0823	Involved in the tonB-independent uptake of proteins
N6H00_RS16395	COG5000	phosphorelay sensor kinase activity
N6H00_RS16395	COG5002	protein histidine kinase activity
N6H00_RS16400	COG0745	RESPONSE REGULATOR receiver
N6H00_RS16405	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N6H00_RS16435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N6H00_RS16440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N6H00_RS16440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N6H00_RS16440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N6H00_RS16450	COG1482	cell wall glycoprotein biosynthetic process
N6H00_RS16460	COG2835	tetraacyldisaccharide 4'-kinase activity
N6H00_RS16465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N6H00_RS16470	COG1620	l-lactate permease
N6H00_RS16505	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N6H00_RS16510	COG0778	Nitroreductase
N6H00_RS16510	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
N6H00_RS16535	COG1316	TRANSCRIPTIONal
N6H00_RS16540	COG1316	TRANSCRIPTIONal
N6H00_RS16555	COG1316	TRANSCRIPTIONal
N6H00_RS16560	COG1607	acyl-coa hydrolase
N6H00_RS16565	COG1316	TRANSCRIPTIONal
N6H00_RS16575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N6H00_RS16590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N6H00_RS16605	COG5002	protein histidine kinase activity
N6H00_RS16610	COG0745	RESPONSE REGULATOR receiver
N6H00_RS16615	COG3104	oligopeptide transport
N6H00_RS16645	COG1366	Belongs to the anti-sigma-factor antagonist family
N6H00_RS16650	COG1191	sigma factor activity
N6H00_RS16655	COG1228	amidohydrolase
N6H00_RS16670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N6H00_RS16690	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS16705	COG2755	lipolytic protein G-D-S-L family
N6H00_RS16710	COG0183	Belongs to the thiolase family
N6H00_RS16740	COG1136	(ABC) transporter
N6H00_RS16745	COG0577	efflux transmembrane transporter activity
N6H00_RS16750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N6H00_RS16755	COG1252	NADH dehydrogenase
N6H00_RS16775	COG0148	phosphopyruvate hydratase activity
N6H00_RS16785	COG1652	LysM domain
N6H00_RS16790	COG2124	cytochrome p450
N6H00_RS16820	COG2124	cytochrome p450
N6H00_RS16825	COG1024	Enoyl-CoA hydratase
N6H00_RS16845	COG0515	serine threonine protein kinase
N6H00_RS16845	COG2815	serine threonine protein kinase
N6H00_RS16900	COG2986	histidine ammonia-lyase
N6H00_RS16910	COG1024	Enoyl-CoA hydratase
N6H00_RS16920	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
N6H00_RS16930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N6H00_RS16945	COG0424	maF-like protein
N6H00_RS16955	COG4770	biotin carboxylase activity
N6H00_RS16990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N6H00_RS17005	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS17010	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS17015	COG2159	amidohydrolase
N6H00_RS17025	COG2814	Major facilitator Superfamily
N6H00_RS17025	COG0477	Major facilitator Superfamily
N6H00_RS17035	COG1595	DNA-templated transcription, initiation
N6H00_RS17040	COG0745	RESPONSE REGULATOR receiver
N6H00_RS17045	COG2205	protein histidine kinase activity
N6H00_RS17070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N6H00_RS17080	COG2814	Major facilitator Superfamily
N6H00_RS17085	COG0583	DNA-binding transcription factor activity
N6H00_RS17100	COG1079	Belongs to the binding-protein-dependent transport system permease family
N6H00_RS17105	COG4603	Belongs to the binding-protein-dependent transport system permease family
N6H00_RS17110	COG3845	ABC transporter
N6H00_RS17115	COG1744	ABC transporter substrate-binding protein PnrA-like
N6H00_RS17120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N6H00_RS17120	COG1473	amidohydrolase
N6H00_RS17130	COG2089	acid synthase
N6H00_RS17135	COG1083	cytidylyl-transferase
N6H00_RS17145	COG1216	Glycosyl transferase, family 2
N6H00_RS17155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N6H00_RS17160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N6H00_RS17195	COG1309	transcriptional regulator
N6H00_RS17220	COG1063	alcohol dehydrogenase
N6H00_RS17225	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS17235	COG3265	gluconokinase activity
N6H00_RS17240	COG2186	Transcriptional regulator
N6H00_RS17245	COG0667	Aldo Keto reductase
N6H00_RS17275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N6H00_RS17275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N6H00_RS17290	COG1595	DNA-templated transcription, initiation
N6H00_RS17315	COG2009	succinate dehydrogenase
N6H00_RS17325	COG1053	succinate dehydrogenase
N6H00_RS17330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N6H00_RS17340	COG1408	metallophosphoesterase
N6H00_RS17350	COG1686	Belongs to the peptidase S11 family
N6H00_RS17355	COG1295	ribonuclease BN
N6H00_RS17365	COG0180	Tryptophanyl-tRNA synthetase
N6H00_RS17375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N6H00_RS17380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N6H00_RS17385	COG0754	glutathionylspermidine amidase activity
N6H00_RS17395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N6H00_RS17400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N6H00_RS17415	COG0517	IMP dehydrogenase activity
N6H00_RS17415	COG4175	Glycine betaine
N6H00_RS17425	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS17430	COG0039	L-malate dehydrogenase activity
N6H00_RS17440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N6H00_RS17445	COG0138	bifunctional purine biosynthesis protein purh
N6H00_RS17470	COG0045	succinate-CoA ligase (ADP-forming) activity
N6H00_RS17485	COG3552	Protein containing von Willebrand factor type A (VWA) domain
N6H00_RS17495	COG0714	Associated with various cellular activities
N6H00_RS17510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N6H00_RS17515	COG0739	heme binding
N6H00_RS17550	COG0778	Nitroreductase
N6H00_RS17580	COG2197	response regulator
N6H00_RS17600	COG2815	serine threonine protein kinase
N6H00_RS17600	COG0515	serine threonine protein kinase
N6H00_RS17625	COG0519	Catalyzes the synthesis of GMP from XMP
N6H00_RS17625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N6H00_RS17645	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS17655	COG2815	serine threonine protein kinase
N6H00_RS17655	COG0515	serine threonine protein kinase
N6H00_RS17675	COG2197	response regulator
N6H00_RS17680	COG3851	Histidine kinase
N6H00_RS17685	COG1366	Belongs to the anti-sigma-factor antagonist family
N6H00_RS17750	COG0596	Alpha beta hydrolase
N6H00_RS17750	COG2945	thiolester hydrolase activity
N6H00_RS17760	COG4821	SIS domain
N6H00_RS17770	COG0259	pyridoxamine-phosphate oxidase activity
N6H00_RS17780	COG1309	transcriptional regulator
N6H00_RS17785	COG1024	Enoyl-CoA hydratase
N6H00_RS17790	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS17805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N6H00_RS17820	COG0277	FAD linked oxidase domain protein
N6H00_RS17820	COG0247	lactate metabolic process
N6H00_RS17825	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N6H00_RS17840	COG0667	Aldo Keto reductase
N6H00_RS17855	COG1846	Transcriptional regulator
N6H00_RS17860	COG2252	PERMEase
N6H00_RS17885	COG2814	Major facilitator Superfamily
N6H00_RS17895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N6H00_RS17900	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N6H00_RS17935	COG1061	Type III restriction enzyme res subunit
N6H00_RS17945	COG3973	AAA domain
N6H00_RS17970	COG2814	Major facilitator Superfamily
N6H00_RS17985	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N6H00_RS17990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N6H00_RS17995	COG0459	protein refolding
N6H00_RS18000	COG1278	Cold shock
N6H00_RS18015	COG0463	Glycosyl transferase, family 2
N6H00_RS18020	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
N6H00_RS18025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N6H00_RS18025	COG1877	trehalose-phosphatase activity
N6H00_RS18050	COG1105	Belongs to the carbohydrate kinase PfkB family
N6H00_RS18055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N6H00_RS18080	COG3384	dioxygenase
N6H00_RS18100	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS18105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N6H00_RS18135	COG0667	Aldo Keto reductase
N6H00_RS18145	COG1309	transcriptional regulator
N6H00_RS18150	COG1064	alcohol dehydrogenase
N6H00_RS18180	COG1414	Transcriptional regulator
N6H00_RS18205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N6H00_RS18230	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS18235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N6H00_RS18265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6H00_RS18270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6H00_RS18275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N6H00_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS18335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N6H00_RS18345	COG1733	regulation of RNA biosynthetic process
N6H00_RS18390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N6H00_RS18405	COG5183	chlorophyll binding
N6H00_RS18405	COG2133	pyrroloquinoline quinone binding
N6H00_RS18410	COG2197	response regulator
N6H00_RS18425	COG1136	(ABC) transporter
N6H00_RS18425	COG0577	efflux transmembrane transporter activity
N6H00_RS18430	COG2124	cytochrome p450
N6H00_RS18440	COG2315	Protein conserved in bacteria
N6H00_RS18445	COG2208	phosphoserine phosphatase activity
N6H00_RS18445	COG2770	Histidine kinase
N6H00_RS18460	COG0798	PFAM Bile acid sodium symporter
N6H00_RS18465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N6H00_RS18495	COG3842	ATPase activity
N6H00_RS18505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N6H00_RS18520	COG0215	cysteine-tRNA ligase activity
N6H00_RS18525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N6H00_RS18530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N6H00_RS18535	COG1329	Transcriptional regulator
N6H00_RS18550	COG5002	protein histidine kinase activity
N6H00_RS18570	COG2319	Wd-40 repeat
N6H00_RS18570	COG4249	Peptidase C14 caspase catalytic subunit p20
N6H00_RS18580	COG1215	transferase activity, transferring glycosyl groups
N6H00_RS18585	COG2188	Transcriptional regulator
N6H00_RS18660	COG0588	phosphoglycerate mutase activity
N6H00_RS18695	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS18710	COG0494	nUDIX hydrolase
N6H00_RS18710	COG0406	alpha-ribazole phosphatase activity
N6H00_RS18720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N6H00_RS18725	COG0456	acetyltransferase
N6H00_RS18725	COG0454	-acetyltransferase
N6H00_RS18735	COG0737	Belongs to the 5'-nucleotidase family
N6H00_RS18770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N6H00_RS18790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N6H00_RS18800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N6H00_RS18805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N6H00_RS18825	COG0640	Transcriptional regulator
N6H00_RS18830	COG0640	Transcriptional regulator
N6H00_RS18835	COG2197	response regulator
N6H00_RS18850	COG0649	NAD binding
N6H00_RS18865	COG1174	glycine betaine transport
N6H00_RS18870	COG1174	glycine betaine transport
N6H00_RS18875	COG0517	IMP dehydrogenase activity
N6H00_RS18875	COG1125	glycine betaine transport
N6H00_RS18885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N6H00_RS18885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N6H00_RS18900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N6H00_RS18905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N6H00_RS18915	COG0302	gtp cyclohydrolase
N6H00_RS18930	COG0037	tRNA processing
N6H00_RS18940	COG2027	D-alanyl-D-alanine carboxypeptidase
N6H00_RS18945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N6H00_RS18955	COG0586	Pfam SNARE associated Golgi protein
N6H00_RS18965	COG0076	glutamate decarboxylase activity
N6H00_RS18990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N6H00_RS18995	COG1802	Transcriptional regulator
N6H00_RS19000	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS19025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N6H00_RS19025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N6H00_RS19030	COG1077	Cell shape determining protein MreB Mrl
N6H00_RS19045	COG1595	DNA-templated transcription, initiation
N6H00_RS19060	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
N6H00_RS19065	COG2197	response regulator
N6H00_RS19120	COG2197	response regulator
N6H00_RS19125	COG4585	Histidine kinase
N6H00_RS19155	COG1191	sigma factor activity
N6H00_RS19185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N6H00_RS19190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N6H00_RS19195	COG1754	DNA topoisomerase type I activity
N6H00_RS19195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N6H00_RS19205	COG2890	protein-(glutamine-N5) methyltransferase activity
N6H00_RS19215	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
N6H00_RS19220	COG2172	sigma factor antagonist activity
N6H00_RS19225	COG1366	Belongs to the anti-sigma-factor antagonist family
N6H00_RS19230	COG1111	helicase
N6H00_RS19230	COG1205	dead DEAH box helicase
N6H00_RS19295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N6H00_RS19300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N6H00_RS19310	COG2267	carboxylic ester hydrolase activity
N6H00_RS19340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N6H00_RS19365	COG0003	Pfam Anion-transporting ATPase
N6H00_RS19375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N6H00_RS19385	COG1408	metallophosphoesterase
N6H00_RS19495	COG2124	cytochrome p450
N6H00_RS19540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N6H00_RS19545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N6H00_RS19575	COG1073	alpha beta
N6H00_RS19585	COG4585	Histidine kinase
N6H00_RS19590	COG2197	response regulator
N6H00_RS19635	COG3594	Acyltransferase
N6H00_RS19670	COG0702	epimerase
N6H00_RS19685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N6H00_RS19720	COG0205	6-phosphofructokinase activity
N6H00_RS19730	COG1191	sigma factor activity
N6H00_RS19735	COG1191	sigma factor activity
N6H00_RS19750	COG1846	Transcriptional regulator
N6H00_RS19770	COG0477	Major facilitator Superfamily
N6H00_RS19775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
N6H00_RS19785	COG2205	protein histidine kinase activity
N6H00_RS19790	COG0745	RESPONSE REGULATOR receiver
N6H00_RS19840	COG1309	transcriptional regulator
N6H00_RS19845	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS19850	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS19870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N6H00_RS19870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N6H00_RS19905	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS19910	COG1595	DNA-templated transcription, initiation
N6H00_RS19960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N6H00_RS19975	COG0653	protein targeting
N6H00_RS19990	COG0006	proline dipeptidase activity
N6H00_RS19995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N6H00_RS20015	COG1999	signal sequence binding
N6H00_RS20030	COG2837	iron assimilation
N6H00_RS20040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N6H00_RS20045	COG0561	phosphatase activity
N6H00_RS20060	COG0477	Major facilitator Superfamily
N6H00_RS20070	COG2186	Transcriptional regulator
N6H00_RS20075	COG2807	transmembrane transport
N6H00_RS20100	COG1131	(ABC) transporter
N6H00_RS20110	COG0501	Belongs to the peptidase M48B family
N6H00_RS20120	COG0561	phosphatase activity
N6H00_RS20135	COG4988	ABC transporter
N6H00_RS20140	COG1294	oxidase, subunit
N6H00_RS20145	COG1271	oxidase subunit
N6H00_RS20150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N6H00_RS20155	COG1609	Transcriptional regulator
N6H00_RS20175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N6H00_RS20195	COG0662	Cupin 2, conserved barrel domain protein
N6H00_RS20200	COG1950	PFAM Membrane protein of
N6H00_RS20205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N6H00_RS20210	COG0626	cystathionine gamma-synthase activity
N6H00_RS20265	COG0242	peptide deformylase activity
N6H00_RS20280	COG0667	Aldo Keto reductase
N6H00_RS20290	COG0305	Participates in initiation and elongation during chromosome replication
N6H00_RS20295	COG0534	Mate efflux family protein
N6H00_RS20300	COG0359	binds to the 23S rRNA
N6H00_RS20305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N6H00_RS20310	COG0629	single-stranded DNA binding
N6H00_RS20315	COG0360	Binds together with S18 to 16S ribosomal RNA
N6H00_RS20340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N6H00_RS20360	COG0617	tRNA 3'-terminal CCA addition
N6H00_RS20375	COG0515	serine threonine protein kinase
N6H00_RS20375	COG2815	serine threonine protein kinase
N6H00_RS20380	COG1595	DNA-templated transcription, initiation
N6H00_RS20390	COG0492	ferredoxin-NADP+ reductase activity
N6H00_RS20395	COG3118	belongs to the thioredoxin family
N6H00_RS20410	COG1192	Involved in chromosome partitioning
N6H00_RS20415	COG0357	Ribosomal RNA small subunit methyltransferase G
N6H00_RS20425	COG0706	membrane insertase activity
N6H00_RS20430	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N6H00_RS20435	COG0594	ribonuclease P activity
N6H00_RS20440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N6H00_RS20450	COG0592	DNA-directed DNA polymerase activity
N6H00_RS20455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
N6H00_RS20460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N6H00_RS20465	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
N6H00_RS20470	COG0187	DNA topoisomerase II activity
N6H00_RS20475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N6H00_RS20500	COG0515	serine threonine protein kinase
N6H00_RS20530	COG0705	Rhomboid family
N6H00_RS20545	COG3764	Sortase (surface protein transpeptidase)
N6H00_RS20560	COG3764	Sortase (surface protein transpeptidase)
N6H00_RS20565	COG3764	Sortase (surface protein transpeptidase)
N6H00_RS20570	COG0515	serine threonine protein kinase
N6H00_RS20575	COG0768	penicillin binding
N6H00_RS20590	COG1716	ATPase activity
N6H00_RS20595	COG1716	ATPase activity
N6H00_RS20605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N6H00_RS20610	COG1733	regulation of RNA biosynthetic process
N6H00_RS20655	COG1309	transcriptional regulator
N6H00_RS20660	COG1522	sequence-specific DNA binding
N6H00_RS20685	COG0303	'Molybdopterin
N6H00_RS20690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N6H00_RS20695	COG3321	synthase
N6H00_RS20695	COG0604	alcohol dehydrogenase
N6H00_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS20710	COG0515	serine threonine protein kinase
N6H00_RS20715	COG0515	serine threonine protein kinase
N6H00_RS20735	COG0022	dehydrogenase e1 component
N6H00_RS20740	COG0508	dehydrogenase complex catalyzes the overall conversion of
N6H00_RS20775	COG1362	aminopeptidase activity
N6H00_RS20790	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS20800	COG1741	Belongs to the pirin family
N6H00_RS20830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N6H00_RS20845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N6H00_RS20860	COG3285	dna ligase
N6H00_RS20860	COG1793	dna ligase
N6H00_RS20870	COG1793	dna ligase
N6H00_RS20885	COG3290	protein histidine kinase activity
N6H00_RS20895	COG2018	Roadblock/LC7 domain
N6H00_RS20920	COG3959	Transketolase, thiamine diphosphate binding domain
N6H00_RS20970	COG0725	ABC transporter, periplasmic molybdate-binding protein
N6H00_RS21025	COG0515	serine threonine protein kinase
N6H00_RS21025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N6H00_RS21040	COG2304	oxidoreductase activity
N6H00_RS21075	COG0726	polysaccharide deacetylase
N6H00_RS21145	COG0717	Belongs to the dCTP deaminase family
N6H00_RS21150	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N6H00_RS21165	COG3290	protein histidine kinase activity
N6H00_RS21170	COG0247	lactate metabolic process
N6H00_RS21170	COG2181	nitrate reductase activity
N6H00_RS21175	COG0443	Heat shock 70 kDa protein
N6H00_RS21180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N6H00_RS21185	COG0484	heat shock protein binding
N6H00_RS21190	COG0789	Transcriptional regulator
N6H00_RS21200	COG1595	DNA-templated transcription, initiation
N6H00_RS21215	COG0477	Major facilitator Superfamily
N6H00_RS21225	COG0542	response to heat
N6H00_RS21270	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N6H00_RS21285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N6H00_RS21290	COG0191	fructose-bisphosphate aldolase activity
N6H00_RS21295	COG0477	Major facilitator Superfamily
N6H00_RS21310	COG3844	kynureninase activity
N6H00_RS21335	COG3559	Exporter of polyketide antibiotics
N6H00_RS21340	COG1131	(ABC) transporter
N6H00_RS21355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N6H00_RS21360	COG0515	serine threonine protein kinase
N6H00_RS21360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N6H00_RS21370	COG1802	Transcriptional regulator
N6H00_RS21385	COG0151	Belongs to the GarS family
N6H00_RS21405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N6H00_RS21450	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N6H00_RS21455	COG0047	phosphoribosylformylglycinamidine synthase activity
N6H00_RS21460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N6H00_RS21480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N6H00_RS21490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N6H00_RS21515	COG1643	Atp-dependent helicase
N6H00_RS21575	COG0513	Belongs to the DEAD box helicase family
N6H00_RS21620	COG0741	lytic transglycosylase activity
N6H00_RS21620	COG0739	heme binding
N6H00_RS21620	COG1196	nuclear chromosome segregation
N6H00_RS21625	COG0667	Aldo Keto reductase
N6H00_RS21650	COG0556	nucleotide-excision repair
N6H00_RS21665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N6H00_RS21670	COG0579	oxidoreductase
N6H00_RS21695	COG1252	NADH dehydrogenase
N6H00_RS21710	COG1846	Transcriptional regulator
N6H00_RS21765	COG0741	lytic transglycosylase activity
N6H00_RS21765	COG1196	nuclear chromosome segregation
N6H00_RS21765	COG0739	heme binding
N6H00_RS21770	COG0671	phosphoesterase, PA-phosphatase related
N6H00_RS21775	COG0277	FAD linked oxidase domain protein
N6H00_RS21795	COG1937	Protein conserved in bacteria
N6H00_RS21805	COG0306	phosphate transporter
N6H00_RS21810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N6H00_RS21835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N6H00_RS21865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N6H00_RS21870	COG0667	Aldo Keto reductase
N6H00_RS21885	COG4552	Acetyltransferase involved in intracellular survival and related
N6H00_RS21895	COG1490	D-aminoacyl-tRNA deacylase activity
N6H00_RS21900	COG0354	folic acid binding
N6H00_RS21905	COG0735	belongs to the Fur family
N6H00_RS21910	COG3485	protocatechuate 3,4-dioxygenase
N6H00_RS21930	COG2897	thiosulfate sulfurtransferase activity
N6H00_RS21965	COG0745	RESPONSE REGULATOR receiver
N6H00_RS21970	COG1609	Transcriptional regulator
N6H00_RS21975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N6H00_RS21995	COG1132	(ABC) transporter
N6H00_RS22005	COG0724	RNA recognition motif
N6H00_RS22015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N6H00_RS22030	COG1132	(ABC) transporter
N6H00_RS22095	COG0739	heme binding
N6H00_RS22105	COG0477	Major facilitator Superfamily
N6H00_RS22110	COG2205	protein histidine kinase activity
N6H00_RS22115	COG0745	RESPONSE REGULATOR receiver
N6H00_RS22125	COG1595	DNA-templated transcription, initiation
N6H00_RS22140	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
N6H00_RS22160	COG0248	Ppx GppA phosphatase
N6H00_RS22165	COG1082	Xylose isomerase domain protein TIM barrel
N6H00_RS22175	COG0129	dihydroxy-acid dehydratase activity
N6H00_RS22180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N6H00_RS22180	COG0515	serine threonine protein kinase
N6H00_RS22200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N6H00_RS22205	COG0180	Tryptophanyl-tRNA synthetase
N6H00_RS22225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N6H00_RS22235	COG0123	including yeast histone deacetylase and acetoin utilization protein
N6H00_RS22285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N6H00_RS22290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N6H00_RS22295	COG0181	hydroxymethylbilane synthase activity
N6H00_RS22300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N6H00_RS22300	COG1648	precorrin-2 dehydrogenase activity
N6H00_RS22305	COG0113	porphobilinogen synthase activity
N6H00_RS22320	COG1072	(Pantothenic acid kinase))
N6H00_RS22330	COG1846	Transcriptional regulator
N6H00_RS22330	COG1940	carbohydrate kinase activity
N6H00_RS22350	COG0018	arginyl-trna synthetase
N6H00_RS22355	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
N6H00_RS22375	COG1690	Belongs to the RtcB family
N6H00_RS22390	COG1742	UPF0060 membrane protein
N6H00_RS22400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N6H00_RS22405	COG0406	alpha-ribazole phosphatase activity
N6H00_RS22420	COG0785	Cytochrome C biogenesis protein
N6H00_RS22425	COG1333	cytochrome c biogenesis protein
N6H00_RS22430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N6H00_RS22440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N6H00_RS22445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N6H00_RS22450	COG0163	prenyltransferase activity
N6H00_RS22465	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N6H00_RS22470	COG1573	uracil-dna glycosylase
N6H00_RS22485	COG1301	dicarboxylic acid transport
N6H00_RS22500	COG1309	transcriptional regulator
N6H00_RS22510	COG1278	Cold shock
N6H00_RS22515	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N6H00_RS22525	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N6H00_RS22535	COG2226	methyltransferase
N6H00_RS22555	COG0791	NLP P60 protein
N6H00_RS22555	COG1388	LysM domain
N6H00_RS22555	COG3103	Sh3 type 3 domain protein
N6H00_RS22565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6H00_RS22570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6H00_RS22575	COG0649	NAD binding
N6H00_RS22585	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N6H00_RS22590	COG1034	ATP synthesis coupled electron transport
N6H00_RS22595	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N6H00_RS22600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6H00_RS22605	COG0839	Belongs to the complex I subunit 6 family
N6H00_RS22610	COG0713	ATP synthesis coupled electron transport
N6H00_RS22615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N6H00_RS22625	COG1007	ATP synthesis coupled electron transport
N6H00_RS22640	COG0142	geranyltranstransferase activity
N6H00_RS22670	COG0702	epimerase
N6H00_RS22675	COG0531	amino acid
N6H00_RS22680	COG1013	pyruvate-flavodoxin oxidoreductase activity
N6H00_RS22685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N6H00_RS22685	COG0674	pyruvate-flavodoxin oxidoreductase activity
N6H00_RS22695	COG4585	Histidine kinase
N6H00_RS22700	COG4585	Histidine kinase
N6H00_RS22705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6H00_RS22710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6H00_RS22715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6H00_RS22725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6H00_RS22730	COG0839	Belongs to the complex I subunit 6 family
N6H00_RS22735	COG0713	ATP synthesis coupled electron transport
N6H00_RS22740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N6H00_RS22750	COG1007	ATP synthesis coupled electron transport
N6H00_RS22755	COG0501	Belongs to the peptidase M48B family
N6H00_RS22760	COG3304	Inner membrane component domain
N6H00_RS22765	COG1666	GTP binding
N6H00_RS22785	COG1970	mechanosensitive ion channel activity
N6H00_RS22800	COG0702	epimerase
N6H00_RS22820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N6H00_RS22825	COG2030	dehydratase
N6H00_RS22835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N6H00_RS22840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N6H00_RS22845	COG0436	Aminotransferase
N6H00_RS22865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N6H00_RS22870	COG0081	regulation of translation
N6H00_RS22880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N6H00_RS22885	COG0222	ribosome binding
N6H00_RS22890	COG0085	RNA polymerase activity
N6H00_RS22895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N6H00_RS22920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N6H00_RS22955	COG3321	synthase
N6H00_RS22955	COG0604	alcohol dehydrogenase
N6H00_RS22960	COG0604	alcohol dehydrogenase
N6H00_RS22960	COG3321	synthase
N6H00_RS22970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS22980	COG1309	transcriptional regulator
N6H00_RS23025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N6H00_RS23030	COG0049	tRNA binding
N6H00_RS23035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N6H00_RS23040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N6H00_RS23065	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS23090	COG0051	transcription antitermination factor activity, RNA binding
N6H00_RS23095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N6H00_RS23100	COG0088	Forms part of the polypeptide exit tunnel
N6H00_RS23105	COG0089	rRNA binding
N6H00_RS23110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N6H00_RS23115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N6H00_RS23120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N6H00_RS23125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N6H00_RS23130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N6H00_RS23135	COG0255	Belongs to the universal ribosomal protein uL29 family
N6H00_RS23140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N6H00_RS23145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N6H00_RS23150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N6H00_RS23155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N6H00_RS23160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N6H00_RS23165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N6H00_RS23170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N6H00_RS23175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N6H00_RS23180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N6H00_RS23190	COG0200	Binds to the 23S rRNA
N6H00_RS23200	COG0563	adenylate kinase activity
N6H00_RS23210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N6H00_RS23215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N6H00_RS23220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N6H00_RS23225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N6H00_RS23230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N6H00_RS23235	COG0202	RNA polymerase activity
N6H00_RS23240	COG0203	ribosomal protein L17
N6H00_RS23245	COG0101	tRNA pseudouridine synthase activity
N6H00_RS23250	COG1366	Belongs to the anti-sigma-factor antagonist family
N6H00_RS23255	COG1366	Belongs to the anti-sigma-factor antagonist family
N6H00_RS23260	COG2172	sigma factor antagonist activity
N6H00_RS23270	COG2208	phosphoserine phosphatase activity
N6H00_RS23270	COG2770	Histidine kinase
N6H00_RS23280	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS23290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N6H00_RS23295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N6H00_RS23300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N6H00_RS23310	COG1072	(Pantothenic acid kinase))
N6H00_RS23315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N6H00_RS23320	COG0736	holo-[acyl-carrier-protein] synthase activity
N6H00_RS23340	COG0535	radical SAM domain protein
N6H00_RS23355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N6H00_RS23365	COG0802	atpase or kinase
N6H00_RS23390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N6H00_RS23400	COG3903	Transcriptional regulator
N6H00_RS23400	COG3629	intracellular signal transduction
N6H00_RS23405	COG0596	Alpha beta hydrolase
N6H00_RS23440	COG0726	polysaccharide deacetylase
N6H00_RS23445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N6H00_RS23450	COG0459	protein refolding
N6H00_RS23455	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS23465	COG0583	DNA-binding transcription factor activity
N6H00_RS23475	COG2197	response regulator
N6H00_RS23480	COG1595	DNA-templated transcription, initiation
N6H00_RS23490	COG0516	GMP reductase activity
N6H00_RS23500	COG1077	Cell shape determining protein MreB Mrl
N6H00_RS23515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N6H00_RS23535	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS23540	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS23545	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS23560	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS23565	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS23590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N6H00_RS23595	COG1024	Enoyl-CoA hydratase
N6H00_RS23605	COG2072	flavoprotein involved in K transport
N6H00_RS23620	COG0259	pyridoxamine-phosphate oxidase activity
N6H00_RS23630	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS23640	COG1309	transcriptional regulator
N6H00_RS23650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N6H00_RS23650	COG0515	serine threonine protein kinase
N6H00_RS23665	COG1024	Enoyl-CoA hydratase
N6H00_RS23685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS23755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N6H00_RS23760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N6H00_RS23765	COG0494	nUDIX hydrolase
N6H00_RS23790	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N6H00_RS23820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N6H00_RS23845	COG1686	Belongs to the peptidase S11 family
N6H00_RS23855	COG1653	transport
N6H00_RS23870	COG0515	serine threonine protein kinase
N6H00_RS23900	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N6H00_RS23905	COG1793	dna ligase
N6H00_RS23905	COG3285	dna ligase
N6H00_RS23910	COG1793	dna ligase
N6H00_RS23915	COG2515	1-aminocyclopropane-1-carboxylate deaminase
N6H00_RS23940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N6H00_RS23975	COG0405	Gamma-glutamyltransferase
N6H00_RS23995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N6H00_RS24010	COG3486	L-lysine 6-monooxygenase (NADPH) activity
N6H00_RS24020	COG0626	cystathionine gamma-synthase activity
N6H00_RS24045	COG0596	Alpha beta hydrolase
N6H00_RS24085	COG2197	response regulator
N6H00_RS24090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N6H00_RS24095	COG1309	transcriptional regulator
N6H00_RS24100	COG3246	L-lysine catabolic process to acetate
N6H00_RS24105	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS24110	COG0824	Thioesterase
N6H00_RS24110	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS24200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N6H00_RS24335	COG3328	transposase activity
N6H00_RS24340	COG3328	transposase activity
N6H00_RS24380	COG3486	L-lysine 6-monooxygenase (NADPH) activity
N6H00_RS24425	COG1309	transcriptional regulator
N6H00_RS24445	COG1846	Transcriptional regulator
N6H00_RS24450	COG3384	dioxygenase
N6H00_RS24470	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS24475	COG1349	DNA-binding transcription factor activity
N6H00_RS24480	COG1105	Belongs to the carbohydrate kinase PfkB family
N6H00_RS24485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N6H00_RS24485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N6H00_RS24485	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N6H00_RS24495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N6H00_RS24505	COG1970	mechanosensitive ion channel activity
N6H00_RS24515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N6H00_RS24525	COG3263	regulation of cellular component size
N6H00_RS24535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N6H00_RS24540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N6H00_RS24550	COG0315	cyclic pyranopterin monophosphate synthase activity
N6H00_RS24555	COG0315	cyclic pyranopterin monophosphate synthase activity
N6H00_RS24555	COG0521	Mo-molybdopterin cofactor biosynthetic process
N6H00_RS24560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N6H00_RS24590	COG0708	Exodeoxyribonuclease III
N6H00_RS24600	COG2072	flavoprotein involved in K transport
N6H00_RS24605	COG2267	carboxylic ester hydrolase activity
N6H00_RS24620	COG4946	Tricorn protease homolog
N6H00_RS24620	COG0793	Belongs to the peptidase S41A family
N6H00_RS24630	COG2409	Drug exporters of the RND superfamily
N6H00_RS24635	COG0310	cobalt ion transport
N6H00_RS24645	COG1122	ATPase activity
N6H00_RS24660	COG4166	transmembrane transport
N6H00_RS24705	COG0084	hydrolase, TatD family'
N6H00_RS24715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N6H00_RS24720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N6H00_RS24725	COG0488	(ABC) transporter
N6H00_RS24760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N6H00_RS24765	COG2197	response regulator
N6H00_RS24775	COG4106	trans-aconitate 2-methyltransferase activity
N6H00_RS24800	COG1309	transcriptional regulator
N6H00_RS24810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N6H00_RS24820	COG0193	aminoacyl-tRNA hydrolase activity
N6H00_RS24825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N6H00_RS24830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N6H00_RS24835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N6H00_RS24850	COG4585	Histidine kinase
N6H00_RS24880	COG0477	Major facilitator Superfamily
N6H00_RS24885	COG1136	(ABC) transporter
N6H00_RS24890	COG0577	efflux transmembrane transporter activity
N6H00_RS24900	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
N6H00_RS24960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N6H00_RS24965	COG2186	Transcriptional regulator
N6H00_RS24975	COG2376	Dihydroxyacetone kinase
N6H00_RS24980	COG0698	ribose 5-phosphate isomerase
N6H00_RS24985	COG0149	triose-phosphate isomerase activity
N6H00_RS24990	COG1082	Xylose isomerase domain protein TIM barrel
N6H00_RS24995	COG2084	Dehydrogenase
N6H00_RS25030	COG1476	TRANSCRIPTIONal
N6H00_RS25060	COG4608	Belongs to the ABC transporter superfamily
N6H00_RS25065	COG0444	Belongs to the ABC transporter superfamily
N6H00_RS25070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6H00_RS25075	COG0601	transmembrane transport
N6H00_RS25085	COG2186	Transcriptional regulator
N6H00_RS25115	COG5002	protein histidine kinase activity
N6H00_RS25120	COG2018	Roadblock/LC7 domain
N6H00_RS25140	COG2226	methyltransferase
N6H00_RS25200	COG2801	Transposase and inactivated derivatives
N6H00_RS25225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N6H00_RS25255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N6H00_RS25260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N6H00_RS25270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N6H00_RS25290	COG1331	Highly conserved protein containing a thioredoxin domain
N6H00_RS25300	COG1272	protein, Hemolysin III
N6H00_RS25305	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N6H00_RS25330	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS25335	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N6H00_RS25345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6H00_RS25350	COG1414	Transcriptional regulator
N6H00_RS25360	COG2610	gluconate transmembrane transporter activity
N6H00_RS25365	COG1131	(ABC) transporter
N6H00_RS25425	COG2894	cell division
N6H00_RS25465	COG2885	chlorophyll binding
N6H00_RS25470	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N6H00_RS25475	COG1278	Cold shock
N6H00_RS25490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N6H00_RS25495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N6H00_RS25510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N6H00_RS25515	COG0450	alkyl hydroperoxide reductase
N6H00_RS25535	COG1136	(ABC) transporter
N6H00_RS25555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N6H00_RS25570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N6H00_RS25575	COG1309	transcriptional regulator
N6H00_RS25585	COG2264	protein methyltransferase activity
N6H00_RS25595	COG0114	fumarate hydratase activity
N6H00_RS25610	COG3979	chitinase
N6H00_RS25615	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
N6H00_RS25615	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
N6H00_RS25640	COG0778	Nitroreductase
N6H00_RS25645	COG1722	exodeoxyribonuclease VII activity
N6H00_RS25650	COG1570	exodeoxyribonuclease VII activity
N6H00_RS25655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N6H00_RS25670	COG0012	GTP binding
N6H00_RS25690	COG0513	Belongs to the DEAD box helicase family
N6H00_RS25695	COG1278	Cold shock
N6H00_RS25720	COG0531	amino acid
N6H00_RS25765	COG1217	gtp-binding protein TYPA
N6H00_RS25775	COG0601	transmembrane transport
N6H00_RS25780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6H00_RS25785	COG0444	Belongs to the ABC transporter superfamily
N6H00_RS25790	COG4608	Belongs to the ABC transporter superfamily
N6H00_RS25820	COG0601	transmembrane transport
N6H00_RS25825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6H00_RS25835	COG4608	Belongs to the ABC transporter superfamily
N6H00_RS25845	COG4608	Belongs to the ABC transporter superfamily
N6H00_RS25850	COG0444	Belongs to the ABC transporter superfamily
N6H00_RS25860	COG0747	negative chemotaxis
N6H00_RS25865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6H00_RS25885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N6H00_RS25925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N6H00_RS25930	COG1611	Belongs to the LOG family
N6H00_RS25945	COG0519	Catalyzes the synthesis of GMP from XMP
N6H00_RS25950	COG1024	Enoyl-CoA hydratase
N6H00_RS25965	COG1595	DNA-templated transcription, initiation
N6H00_RS25975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N6H00_RS25980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N6H00_RS26020	COG0598	Magnesium transport protein CorA
N6H00_RS26045	COG1432	Conserved Protein
N6H00_RS26050	COG0596	Alpha beta hydrolase
N6H00_RS26145	COG0210	DNA helicase
N6H00_RS26150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N6H00_RS26165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N6H00_RS26195	COG0667	Aldo Keto reductase
N6H00_RS26250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N6H00_RS26300	COG3480	Lon protease (S16) C-terminal proteolytic domain
N6H00_RS26310	COG1615	UPF0182 protein
N6H00_RS26335	COG0753	catalase activity
N6H00_RS26345	COG0483	inositol monophosphate 1-phosphatase activity
N6H00_RS26355	COG2076	Multidrug Resistance protein
N6H00_RS26360	COG1162	GTPase activity
N6H00_RS26365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N6H00_RS26375	COG2135	peptidase activity
N6H00_RS26385	COG1595	DNA-templated transcription, initiation
N6H00_RS26390	COG5662	AntiSigma factor
N6H00_RS26395	COG2199	diguanylate cyclase activity
N6H00_RS26395	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N6H00_RS26410	COG0242	peptide deformylase activity
N6H00_RS26415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N6H00_RS26430	COG0588	phosphoglycerate mutase activity
N6H00_RS26435	COG1349	DNA-binding transcription factor activity
N6H00_RS26490	COG1309	transcriptional regulator
N6H00_RS26550	COG2188	Transcriptional regulator
N6H00_RS26555	COG2182	Extracellular solute-binding protein
N6H00_RS26560	COG1175	transmembrane transport
N6H00_RS26565	COG0395	ABC-type sugar transport system, permease component
N6H00_RS26570	COG1472	Belongs to the glycosyl hydrolase 3 family
N6H00_RS26575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N6H00_RS26590	COG1597	lipid kinase activity
N6H00_RS26630	COG2066	Belongs to the glutaminase family
N6H00_RS26650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N6H00_RS26670	COG5640	endopeptidase activity
N6H00_RS26720	COG1126	abc transporter atp-binding protein
N6H00_RS26725	COG0765	amino acid transport
N6H00_RS26735	COG0281	malic enzyme
N6H00_RS26760	COG0300	oxidoreductase activity
N6H00_RS26760	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS26760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N6H00_RS26760	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS26760	COG3321	synthase
N6H00_RS26775	COG0778	Nitroreductase
N6H00_RS26795	COG0567	Dehydrogenase, E1 component
N6H00_RS26795	COG0508	dehydrogenase complex catalyzes the overall conversion of
N6H00_RS26800	COG2205	protein histidine kinase activity
N6H00_RS26805	COG0745	RESPONSE REGULATOR receiver
N6H00_RS26820	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N6H00_RS26870	COG1388	LysM domain
N6H00_RS26870	COG3103	Sh3 type 3 domain protein
N6H00_RS26870	COG0791	NLP P60 protein
N6H00_RS26900	COG2814	Major facilitator Superfamily
N6H00_RS26910	COG0477	Major facilitator Superfamily
N6H00_RS26930	COG1201	RNA secondary structure unwinding
N6H00_RS27015	COG0583	DNA-binding transcription factor activity
N6H00_RS27090	COG0745	RESPONSE REGULATOR receiver
N6H00_RS27095	COG0018	arginyl-trna synthetase
N6H00_RS27095	COG0018	arginyl-trna synthetase
N6H00_RS27100	COG0019	diaminopimelate decarboxylase activity
N6H00_RS27105	COG0460	homoserine dehydrogenase
N6H00_RS27110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N6H00_RS27115	COG0083	homoserine kinase activity
N6H00_RS27125	COG1316	TRANSCRIPTIONal
N6H00_RS27130	COG0254	rRNA binding
N6H00_RS27135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N6H00_RS27140	COG2890	protein-(glutamine-N5) methyltransferase activity
N6H00_RS27150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N6H00_RS27155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N6H00_RS27175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N6H00_RS27180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N6H00_RS27185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N6H00_RS27190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N6H00_RS27195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N6H00_RS27200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N6H00_RS27205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N6H00_RS27215	COG2197	response regulator
N6H00_RS27220	COG4585	Histidine kinase
N6H00_RS27250	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS27265	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
N6H00_RS27315	COG0183	Belongs to the thiolase family
N6H00_RS27330	COG0745	RESPONSE REGULATOR receiver
N6H00_RS27335	COG2205	protein histidine kinase activity
N6H00_RS27390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N6H00_RS27390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N6H00_RS27425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N6H00_RS27430	COG0280	phosphate acetyltransferase
N6H00_RS27430	COG0857	belongs to the CobB CobQ family
N6H00_RS27435	COG0205	6-phosphofructokinase activity
N6H00_RS27455	COG3833	ABC-type maltose transport systems, permease component
N6H00_RS27465	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS27470	COG0300	oxidoreductase activity
N6H00_RS27480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N6H00_RS27490	COG1175	transmembrane transport
N6H00_RS27500	COG3469	chitinase activity
N6H00_RS27505	COG4565	transcriptional regulatory protein
N6H00_RS27510	COG3290	protein histidine kinase activity
N6H00_RS27515	COG1301	dicarboxylic acid transport
N6H00_RS27525	COG3903	Transcriptional regulator
N6H00_RS27525	COG3629	intracellular signal transduction
N6H00_RS27535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N6H00_RS27540	COG3281	Trehalose synthase
N6H00_RS27550	COG0366	Alpha amylase catalytic
N6H00_RS27565	COG3401	FG-GAP repeat protein
N6H00_RS27570	COG0058	SHG alpha-glucan phosphorylase activity
N6H00_RS27635	COG1309	transcriptional regulator
N6H00_RS27660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N6H00_RS27675	COG3340	Belongs to the peptidase S51 family
N6H00_RS27705	COG1132	(ABC) transporter
N6H00_RS27710	COG1132	(ABC) transporter
N6H00_RS27800	COG1846	Transcriptional regulator
N6H00_RS27820	COG1595	DNA-templated transcription, initiation
N6H00_RS27840	COG1760	l-serine dehydratase
N6H00_RS27845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N6H00_RS27850	COG0509	glycine decarboxylation via glycine cleavage system
N6H00_RS27855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N6H00_RS27880	COG4166	transmembrane transport
N6H00_RS27890	COG0444	Belongs to the ABC transporter superfamily
N6H00_RS27895	COG4608	Belongs to the ABC transporter superfamily
N6H00_RS27900	COG2860	membrane
N6H00_RS27925	COG0482	sulfurtransferase activity
N6H00_RS27940	COG0300	oxidoreductase activity
N6H00_RS27955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N6H00_RS27965	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N6H00_RS27970	COG0154	amidase activity
N6H00_RS27980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N6H00_RS27995	COG1672	PFAM Archaeal ATPase
N6H00_RS27995	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
N6H00_RS28005	COG2133	pyrroloquinoline quinone binding
N6H00_RS28010	COG0667	Aldo Keto reductase
N6H00_RS28030	COG0440	acetolactate synthase activity
N6H00_RS28035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N6H00_RS28065	COG0477	Major facilitator Superfamily
N6H00_RS28080	COG0506	proline dehydrogenase activity
N6H00_RS28085	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS28100	COG0473	3-isopropylmalate dehydrogenase activity
N6H00_RS28105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N6H00_RS28110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N6H00_RS28115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N6H00_RS28135	COG2018	Roadblock/LC7 domain
N6H00_RS28155	COG2018	Roadblock/LC7 domain
N6H00_RS28160	COG5002	protein histidine kinase activity
N6H00_RS28170	COG0179	Fumarylacetoacetate (FAA) hydrolase
N6H00_RS28175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N6H00_RS28205	COG1414	Transcriptional regulator
N6H00_RS28210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N6H00_RS28215	COG0066	3-isopropylmalate dehydratase activity
N6H00_RS28225	COG0776	regulation of translation
N6H00_RS28240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N6H00_RS28245	COG1181	Belongs to the D-alanine--D-alanine ligase family
N6H00_RS28265	COG0351	phosphomethylpyrimidine kinase
N6H00_RS28270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N6H00_RS28275	COG1461	Dihydroxyacetone kinase
N6H00_RS28280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N6H00_RS28285	COG0742	ribosomal rna small subunit methyltransferase
N6H00_RS28290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N6H00_RS28305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N6H00_RS28310	COG0571	ribonuclease III activity
N6H00_RS28315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N6H00_RS28320	COG1733	regulation of RNA biosynthetic process
N6H00_RS28325	COG2340	Cysteine-rich secretory protein family
N6H00_RS28330	COG1254	Belongs to the acylphosphatase family
N6H00_RS28345	COG0477	Major facilitator Superfamily
N6H00_RS28365	COG4585	Histidine kinase
N6H00_RS28370	COG2197	response regulator
N6H00_RS28400	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N6H00_RS28415	COG0442	prolyl-tRNA aminoacylation
N6H00_RS28425	COG0228	four-way junction DNA binding
N6H00_RS28430	COG1837	Belongs to the UPF0109 family
N6H00_RS28435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N6H00_RS28440	COG0336	Belongs to the RNA methyltransferase TrmD family
N6H00_RS28445	COG0335	large ribosomal subunit rRNA binding
N6H00_RS28460	COG0681	Belongs to the peptidase S26 family
N6H00_RS28465	COG0681	Belongs to the peptidase S26 family
N6H00_RS28480	COG0792	nuclease activity
N6H00_RS28495	COG1191	sigma factor activity
N6H00_RS28510	COG0052	Belongs to the universal ribosomal protein uS2 family
N6H00_RS28515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N6H00_RS28520	COG0528	UMP kinase activity
N6H00_RS28525	COG0233	cytoplasmic translational termination
N6H00_RS28530	COG0575	Belongs to the CDS family
N6H00_RS28535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N6H00_RS28545	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N6H00_RS28550	COG3842	ATPase activity
N6H00_RS28565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N6H00_RS28570	COG0028	Belongs to the TPP enzyme family
N6H00_RS28580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N6H00_RS28590	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS28600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N6H00_RS28620	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS28625	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N6H00_RS28630	COG3842	ATPase activity
N6H00_RS28635	COG1176	ABC-type spermidine putrescine transport system, permease component I
N6H00_RS28640	COG1177	transmembrane transport
N6H00_RS28645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N6H00_RS28665	COG2508	Transcriptional regulator
N6H00_RS28670	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS28675	COG1472	Belongs to the glycosyl hydrolase 3 family
N6H00_RS28685	COG4209	transmembrane transport
N6H00_RS28690	COG0395	ABC-type sugar transport system, permease component
N6H00_RS28715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N6H00_RS28720	COG0750	zinc metalloprotease
N6H00_RS28725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N6H00_RS28740	COG0442	prolyl-tRNA aminoacylation
N6H00_RS28760	COG0779	Required for maturation of 30S ribosomal subunits
N6H00_RS28775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N6H00_RS28785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N6H00_RS28790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N6H00_RS28800	COG0455	bacterial-type flagellum organization
N6H00_RS28820	COG1404	Belongs to the peptidase S8 family
N6H00_RS28870	COG1674	ftsk spoiiie
N6H00_RS28890	COG1404	Belongs to the peptidase S8 family
N6H00_RS28910	COG1674	ftsk spoiiie
N6H00_RS28945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N6H00_RS28950	COG1185	polyribonucleotide nucleotidyltransferase activity
N6H00_RS28955	COG0612	Peptidase, M16
N6H00_RS28960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N6H00_RS28980	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
N6H00_RS28985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N6H00_RS28990	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N6H00_RS29020	COG2208	phosphoserine phosphatase activity
N6H00_RS29020	COG2770	Histidine kinase
N6H00_RS29025	COG3850	Histidine kinase
N6H00_RS29025	COG3437	response regulator, receiver
N6H00_RS29025	COG2205	protein histidine kinase activity
N6H00_RS29025	COG4999	Histidine kinase
N6H00_RS29035	COG1674	ftsk spoiiie
N6H00_RS29045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N6H00_RS29055	COG1546	Belongs to the CinA family
N6H00_RS29055	COG1058	Belongs to the CinA family
N6H00_RS29060	COG1396	sequence-specific DNA binding
N6H00_RS29075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N6H00_RS29080	COG1201	RNA secondary structure unwinding
N6H00_RS29085	COG2207	Transcriptional regulator
N6H00_RS29085	COG1917	Cupin 2, conserved barrel domain protein
N6H00_RS29115	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N6H00_RS29125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N6H00_RS29135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS29140	COG0765	amino acid transport
N6H00_RS29145	COG0765	amino acid transport
N6H00_RS29150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N6H00_RS29155	COG1126	abc transporter atp-binding protein
N6H00_RS29165	COG2205	protein histidine kinase activity
N6H00_RS29175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N6H00_RS29195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N6H00_RS29205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N6H00_RS29210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N6H00_RS29220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N6H00_RS29250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N6H00_RS29255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N6H00_RS29260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N6H00_RS29275	COG0488	(ABC) transporter
N6H00_RS29290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N6H00_RS29320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N6H00_RS29325	COG1802	Transcriptional regulator
N6H00_RS29330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N6H00_RS29345	COG0187	DNA topoisomerase II activity
N6H00_RS29355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N6H00_RS29360	COG4565	transcriptional regulatory protein
N6H00_RS29365	COG3290	protein histidine kinase activity
N6H00_RS29380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N6H00_RS29385	COG0612	Peptidase, M16
N6H00_RS29400	COG1802	Transcriptional regulator
N6H00_RS29405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N6H00_RS29425	COG1435	thymidine kinase activity
N6H00_RS29460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N6H00_RS29465	COG0483	inositol monophosphate 1-phosphatase activity
N6H00_RS29475	COG0745	RESPONSE REGULATOR receiver
N6H00_RS29480	COG2205	protein histidine kinase activity
N6H00_RS29505	COG0756	dUTP diphosphatase activity
N6H00_RS29545	COG0569	domain protein
N6H00_RS29570	COG0531	amino acid
N6H00_RS29575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N6H00_RS29605	COG0456	acetyltransferase
N6H00_RS29610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N6H00_RS29620	COG5285	phytanoyl-CoA dioxygenase
N6H00_RS29650	COG2040	homocysteine
N6H00_RS29660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N6H00_RS29665	COG4977	sequence-specific DNA binding
N6H00_RS29700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N6H00_RS29725	COG3387	PFAM Glycoside hydrolase 15-related
N6H00_RS29730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N6H00_RS29735	COG0589	response to stress
N6H00_RS29745	COG0129	dihydroxy-acid dehydratase activity
N6H00_RS29755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N6H00_RS29780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N6H00_RS29790	COG3537	Alpha-1,2-mannosidase
N6H00_RS29800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N6H00_RS29815	COG1653	transport
N6H00_RS29820	COG1175	transmembrane transport
N6H00_RS29825	COG0395	ABC-type sugar transport system, permease component
N6H00_RS29830	COG1940	carbohydrate kinase activity
N6H00_RS29835	COG4213	ABC transporter substrate-binding protein
N6H00_RS29845	COG4214	carbohydrate transport
N6H00_RS29850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N6H00_RS29855	COG0531	amino acid
N6H00_RS29870	COG1024	Enoyl-CoA hydratase
N6H00_RS29870	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS29875	COG0183	Belongs to the thiolase family
N6H00_RS29880	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N6H00_RS29895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N6H00_RS29900	COG0446	pyridine nucleotide-disulphide oxidoreductase
N6H00_RS29905	COG2271	Major facilitator Superfamily
N6H00_RS29920	COG1414	Transcriptional regulator
N6H00_RS29925	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
N6H00_RS29930	COG3253	May function as heme-dependent peroxidase
N6H00_RS29950	COG3220	belongs to the UPF0276 family
N6H00_RS29955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N6H00_RS29995	COG0745	RESPONSE REGULATOR receiver
N6H00_RS30000	COG5002	protein histidine kinase activity
N6H00_RS30020	COG1819	glycosyl
N6H00_RS30045	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS30090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N6H00_RS30095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N6H00_RS30140	COG1119	ATPase activity
N6H00_RS30200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N6H00_RS30205	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
N6H00_RS30225	COG0529	Catalyzes the synthesis of activated sulfate
N6H00_RS30230	COG0175	sulfate reduction
N6H00_RS30275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N6H00_RS30285	COG0028	Belongs to the TPP enzyme family
N6H00_RS30310	COG1802	Transcriptional regulator
N6H00_RS30335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N6H00_RS30365	COG0598	Magnesium transport protein CorA
N6H00_RS30370	COG2197	response regulator
N6H00_RS30375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N6H00_RS30380	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS30410	COG2351	hydroxyisourate hydrolase activity
N6H00_RS30425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N6H00_RS30430	COG0746	molybdenum cofactor guanylyltransferase activity
N6H00_RS30440	COG1414	Transcriptional regulator
N6H00_RS30445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N6H00_RS30450	COG4266	Belongs to the allantoicase family
N6H00_RS30470	COG0402	S-adenosylhomocysteine deaminase activity
N6H00_RS30480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N6H00_RS30485	COG0583	DNA-binding transcription factor activity
N6H00_RS30510	COG0800	Aldolase
N6H00_RS30540	COG0601	transmembrane transport
N6H00_RS30545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6H00_RS30555	COG4608	Belongs to the ABC transporter superfamily
N6H00_RS30560	COG2188	Transcriptional regulator
N6H00_RS30580	COG1940	carbohydrate kinase activity
N6H00_RS30590	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N6H00_RS30620	COG1126	abc transporter atp-binding protein
N6H00_RS30625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6H00_RS30630	COG0765	amino acid transport
N6H00_RS30635	COG0765	amino acid transport
N6H00_RS30675	COG0405	Gamma-glutamyltransferase
N6H00_RS30680	COG1335	isochorismatase
N6H00_RS30685	COG0477	Major facilitator Superfamily
N6H00_RS30705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N6H00_RS30710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N6H00_RS30720	COG0483	inositol monophosphate 1-phosphatase activity
N6H00_RS30730	COG0181	hydroxymethylbilane synthase activity
N6H00_RS30740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N6H00_RS30765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N6H00_RS30775	COG1929	Belongs to the glycerate kinase type-1 family
N6H00_RS30785	COG0688	phosphatidylethanolamine metabolic process
N6H00_RS30790	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS30800	COG2301	Belongs to the HpcH HpaI aldolase family
N6H00_RS30805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N6H00_RS30805	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N6H00_RS30815	COG1309	transcriptional regulator
N6H00_RS30855	COG2362	D-Aminopeptidase
N6H00_RS30860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N6H00_RS30890	COG4106	trans-aconitate 2-methyltransferase activity
N6H00_RS30895	COG0516	GMP reductase activity
N6H00_RS30895	COG0517	IMP dehydrogenase activity
N6H00_RS30925	COG0693	protein deglycase activity
N6H00_RS30930	COG0028	Belongs to the TPP enzyme family
N6H00_RS30935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS30995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N6H00_RS31010	COG0662	Cupin 2, conserved barrel domain protein
N6H00_RS31030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N6H00_RS31040	COG2267	carboxylic ester hydrolase activity
N6H00_RS31060	COG4213	ABC transporter substrate-binding protein
N6H00_RS31070	COG4214	carbohydrate transport
N6H00_RS31090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N6H00_RS31110	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N6H00_RS31115	COG0477	Major facilitator Superfamily
N6H00_RS31125	COG2154	pterin-4-alpha-carbinolamine dehydratase
N6H00_RS31135	COG0656	L-ascorbic acid biosynthetic process
N6H00_RS31150	COG0583	DNA-binding transcription factor activity
N6H00_RS31175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N6H00_RS31190	COG3383	formate dehydrogenase (NAD+) activity
N6H00_RS31205	COG1129	ABC transporter
N6H00_RS31210	COG1172	Belongs to the binding-protein-dependent transport system permease family
N6H00_RS31215	COG1879	ABC-type sugar transport system periplasmic component
N6H00_RS31220	COG0673	inositol 2-dehydrogenase activity
N6H00_RS31290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N6H00_RS31300	COG0045	succinate-CoA ligase (ADP-forming) activity
N6H00_RS31310	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS31370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N6H00_RS31380	COG2910	NAD(P)H-binding
N6H00_RS31390	COG1733	regulation of RNA biosynthetic process
N6H00_RS31395	COG0477	Major facilitator Superfamily
N6H00_RS31430	COG0154	amidase activity
N6H00_RS31445	COG1454	alcohol dehydrogenase
N6H00_RS31450	COG3485	protocatechuate 3,4-dioxygenase
N6H00_RS31455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N6H00_RS31470	COG1116	anion transmembrane transporter activity
N6H00_RS31470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N6H00_RS31485	COG2826	transposase and inactivated derivatives, IS30 family
N6H00_RS31495	COG2272	Belongs to the type-B carboxylesterase lipase family
N6H00_RS31500	COG1063	alcohol dehydrogenase
N6H00_RS31510	COG2315	Protein conserved in bacteria
N6H00_RS31515	COG2315	Protein conserved in bacteria
N6H00_RS31520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N6H00_RS31525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N6H00_RS31610	COG1228	amidohydrolase
N6H00_RS31620	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS31655	COG0596	Alpha beta hydrolase
N6H00_RS31675	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N6H00_RS31685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS31695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N6H00_RS31700	COG1053	succinate dehydrogenase
N6H00_RS31775	COG0667	Aldo Keto reductase
N6H00_RS31795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N6H00_RS31830	COG4585	Histidine kinase
N6H00_RS31835	COG2197	response regulator
N6H00_RS31840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N6H00_RS31840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N6H00_RS31850	COG1595	DNA-templated transcription, initiation
N6H00_RS31875	COG0246	Mannitol dehydrogenase
N6H00_RS31880	COG0477	Major facilitator Superfamily
N6H00_RS31885	COG1063	alcohol dehydrogenase
N6H00_RS31910	COG0529	Catalyzes the synthesis of activated sulfate
N6H00_RS31910	COG2046	Belongs to the sulfate adenylyltransferase family
N6H00_RS31915	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS31925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS31935	COG0431	NADPH-dependent FMN reductase
N6H00_RS31965	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS31995	COG1515	deoxyribonuclease V activity
N6H00_RS32005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N6H00_RS32015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N6H00_RS32020	COG0183	Belongs to the thiolase family
N6H00_RS32025	COG1024	Enoyl-CoA hydratase
N6H00_RS32025	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS32030	COG0583	DNA-binding transcription factor activity
N6H00_RS32055	COG2936	dipeptidyl-peptidase activity
N6H00_RS32060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N6H00_RS32070	COG2183	response to ionizing radiation
N6H00_RS32095	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N6H00_RS32135	COG1134	teichoic acid transport
N6H00_RS32155	COG0644	oxidoreductase
N6H00_RS32160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N6H00_RS32180	COG0300	oxidoreductase activity
N6H00_RS32185	COG2124	cytochrome p450
N6H00_RS32195	COG1562	ergosterol biosynthetic process
N6H00_RS32205	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
N6H00_RS32215	COG1657	PFAM Prenyltransferase squalene oxidase
N6H00_RS32230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N6H00_RS32245	COG2365	Tyrosine phosphatase family
N6H00_RS32255	COG2755	lipolytic protein G-D-S-L family
N6H00_RS32330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N6H00_RS32335	COG0531	amino acid
N6H00_RS32350	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS32375	COG1404	Belongs to the peptidase S8 family
N6H00_RS32385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N6H00_RS32395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N6H00_RS32400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N6H00_RS32405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N6H00_RS32410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N6H00_RS32415	COG5002	protein histidine kinase activity
N6H00_RS32420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N6H00_RS32425	COG0072	phenylalanine-tRNA ligase activity
N6H00_RS32425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N6H00_RS32450	COG1285	pathogenesis
N6H00_RS32475	COG1649	PFAM Uncharacterised BCR, COG1649
N6H00_RS32490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N6H00_RS32520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N6H00_RS32525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N6H00_RS32530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N6H00_RS32535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N6H00_RS32540	COG1438	arginine binding
N6H00_RS32545	COG0385	Bile acid
N6H00_RS32570	COG1902	pentaerythritol trinitrate reductase activity
N6H00_RS32585	COG0137	argininosuccinate synthase activity
N6H00_RS32590	COG0165	Argininosuccinate lyase
N6H00_RS32605	COG0204	Acyl-transferase
N6H00_RS32605	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS32640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N6H00_RS32645	COG2011	ABC-type metal ion transport system permease component
N6H00_RS32650	COG1464	Belongs to the NlpA lipoprotein family
N6H00_RS32665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N6H00_RS32670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N6H00_RS32670	COG1648	precorrin-2 dehydrogenase activity
N6H00_RS32695	COG1309	transcriptional regulator
N6H00_RS32740	COG0512	Glutamine amidotransferase of anthranilate synthase
N6H00_RS32740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N6H00_RS32790	COG1653	transport
N6H00_RS32795	COG1175	transmembrane transport
N6H00_RS32805	COG0395	ABC-type sugar transport system, permease component
N6H00_RS32835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N6H00_RS32850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N6H00_RS32870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N6H00_RS32875	COG1560	Kdo2-lipid A biosynthetic process
N6H00_RS32880	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS32890	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
N6H00_RS32895	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
N6H00_RS32900	COG0217	transcriptional regulatory protein
N6H00_RS32905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N6H00_RS32910	COG0632	four-way junction helicase activity
N6H00_RS32915	COG2255	four-way junction helicase activity
N6H00_RS32925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N6H00_RS32930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N6H00_RS32935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N6H00_RS32940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N6H00_RS32945	COG1196	nuclear chromosome segregation
N6H00_RS32950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N6H00_RS32960	COG0124	histidyl-tRNA synthetase
N6H00_RS32990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N6H00_RS33005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N6H00_RS33010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N6H00_RS33020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N6H00_RS33025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N6H00_RS33030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N6H00_RS33035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N6H00_RS33045	COG0006	proline dipeptidase activity
N6H00_RS33050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N6H00_RS33055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N6H00_RS33065	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N6H00_RS33070	COG0540	Belongs to the ATCase OTCase family
N6H00_RS33075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N6H00_RS33085	COG0505	Belongs to the CarA family
N6H00_RS33090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N6H00_RS33095	COG0167	dihydroorotate dehydrogenase activity
N6H00_RS33100	COG0284	orotidine-5'-phosphate decarboxylase activity
N6H00_RS33110	COG0194	GDP metabolic process
N6H00_RS33125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N6H00_RS33140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N6H00_RS33145	COG1132	(ABC) transporter
N6H00_RS33160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N6H00_RS33165	COG2390	Transcriptional regulator
N6H00_RS33185	COG0531	amino acid
N6H00_RS33195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N6H00_RS33210	COG2233	PERMEase
N6H00_RS33225	COG0738	Major facilitator superfamily
N6H00_RS33230	COG1940	carbohydrate kinase activity
N6H00_RS33230	COG1846	Transcriptional regulator
N6H00_RS33245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N6H00_RS33245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N6H00_RS33250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N6H00_RS33255	COG0140	phosphoribosyl-ATP diphosphatase activity
N6H00_RS33260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N6H00_RS33295	COG0189	ligase activity
N6H00_RS33310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N6H00_RS33325	COG2271	Major facilitator Superfamily
N6H00_RS33340	COG1802	Transcriptional regulator
N6H00_RS33355	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS33370	COG2813	Specifically methylates the guanine in position
N6H00_RS33395	COG0076	glutamate decarboxylase activity
N6H00_RS33415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N6H00_RS33420	COG3959	Transketolase, thiamine diphosphate binding domain
N6H00_RS33425	COG3958	Transketolase
N6H00_RS33430	COG0189	ligase activity
N6H00_RS33435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N6H00_RS33440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N6H00_RS33445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N6H00_RS33460	COG1216	Glycosyl transferase, family 2
N6H00_RS33465	COG2197	response regulator
N6H00_RS33475	COG1216	Glycosyl transferase, family 2
N6H00_RS33495	COG0346	lactoylglutathione lyase activity
N6H00_RS33500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N6H00_RS33500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N6H00_RS33535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N6H00_RS33535	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N6H00_RS33540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N6H00_RS33550	COG1063	alcohol dehydrogenase
N6H00_RS33560	COG1063	alcohol dehydrogenase
N6H00_RS33580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N6H00_RS33590	COG1216	Glycosyl transferase, family 2
N6H00_RS33600	COG2226	methyltransferase
N6H00_RS33605	COG4941	Belongs to the sigma-70 factor family
N6H00_RS33620	COG5001	Diguanylate cyclase
N6H00_RS33660	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS33665	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS33705	COG0463	Glycosyl transferase, family 2
N6H00_RS33710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6H00_RS33715	COG1006	Multisubunit Na H antiporter MnhC subunit
N6H00_RS33740	COG3030	protein affecting phage T7 exclusion by the F plasmid
N6H00_RS33755	COG2186	Transcriptional regulator
N6H00_RS33805	COG1556	Lactate utilization protein
N6H00_RS33810	COG1139	Iron-sulfur cluster binding protein
N6H00_RS33815	COG0247	lactate metabolic process
N6H00_RS33820	COG1070	Carbohydrate kinase
N6H00_RS33825	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS33825	COG3347	Dehydrogenase
N6H00_RS33835	COG1129	ABC transporter
N6H00_RS33840	COG1172	Belongs to the binding-protein-dependent transport system permease family
N6H00_RS33865	COG1609	Transcriptional regulator
N6H00_RS33915	COG1131	(ABC) transporter
N6H00_RS33930	COG1309	transcriptional regulator
N6H00_RS33995	COG3424	synthase
N6H00_RS34000	COG1024	Enoyl-CoA hydratase
N6H00_RS34005	COG1024	Enoyl-CoA hydratase
N6H00_RS34015	COG2267	carboxylic ester hydrolase activity
N6H00_RS34020	COG2205	protein histidine kinase activity
N6H00_RS34025	COG0745	RESPONSE REGULATOR receiver
N6H00_RS34035	COG1132	(ABC) transporter
N6H00_RS34050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N6H00_RS34070	COG1136	(ABC) transporter
N6H00_RS34075	COG1136	(ABC) transporter
N6H00_RS34075	COG0577	efflux transmembrane transporter activity
N6H00_RS34080	COG0475	glutathione-regulated potassium exporter activity
N6H00_RS34100	COG1175	transmembrane transport
N6H00_RS34105	COG0395	ABC-type sugar transport system, permease component
N6H00_RS34115	COG1874	Beta-galactosidase
N6H00_RS34120	COG1472	Belongs to the glycosyl hydrolase 3 family
N6H00_RS34175	COG0501	Belongs to the peptidase M48B family
N6H00_RS34190	COG0604	alcohol dehydrogenase
N6H00_RS34190	COG3321	synthase
N6H00_RS34190	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS34205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N6H00_RS34225	COG0642	Histidine kinase
N6H00_RS34230	COG2018	Roadblock/LC7 domain
N6H00_RS34255	COG0395	ABC-type sugar transport system, permease component
N6H00_RS34260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6H00_RS34280	COG0583	DNA-binding transcription factor activity
N6H00_RS34330	COG4565	transcriptional regulatory protein
N6H00_RS34335	COG3290	protein histidine kinase activity
N6H00_RS34380	COG1053	succinate dehydrogenase
N6H00_RS34390	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS34410	COG2197	response regulator
N6H00_RS34430	COG1959	2 iron, 2 sulfur cluster binding
N6H00_RS34480	COG4585	Histidine kinase
N6H00_RS34485	COG2197	response regulator
N6H00_RS34490	COG0577	efflux transmembrane transporter activity
N6H00_RS34490	COG1136	(ABC) transporter
N6H00_RS34495	COG1136	(ABC) transporter
N6H00_RS34495	COG0577	efflux transmembrane transporter activity
N6H00_RS34510	COG0277	FAD linked oxidase domain protein
N6H00_RS34515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N6H00_RS34530	COG3959	Transketolase, thiamine diphosphate binding domain
N6H00_RS34535	COG3958	Transketolase
N6H00_RS34540	COG2353	YceI-like domain
N6H00_RS34550	COG1301	dicarboxylic acid transport
N6H00_RS34555	COG2188	Transcriptional regulator
N6H00_RS34565	COG4948	Mandelate Racemase Muconate Lactonizing
N6H00_RS34575	COG0137	argininosuccinate synthase activity
N6H00_RS34585	COG0366	Alpha amylase catalytic
N6H00_RS34590	COG0395	ABC-type sugar transport system, permease component
N6H00_RS34595	COG1175	transmembrane transport
N6H00_RS34620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N6H00_RS34625	COG1120	ATPase activity
N6H00_RS34635	COG5006	permease, DMT superfamily
N6H00_RS34655	COG2226	methyltransferase
N6H00_RS34690	COG1929	Belongs to the glycerate kinase type-1 family
N6H00_RS34705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N6H00_RS34710	COG1053	succinate dehydrogenase
N6H00_RS34725	COG2072	flavoprotein involved in K transport
N6H00_RS34740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N6H00_RS34775	COG0789	Transcriptional regulator
N6H00_RS34790	COG0235	Class ii aldolase
N6H00_RS34795	COG3395	kinase activity
N6H00_RS34800	COG0473	3-isopropylmalate dehydrogenase activity
N6H00_RS34805	COG1082	Xylose isomerase domain protein TIM barrel
N6H00_RS34815	COG2851	Citrate transporter
N6H00_RS34830	COG3903	Transcriptional regulator
N6H00_RS34830	COG3629	intracellular signal transduction
N6H00_RS34840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS34845	COG0702	epimerase
N6H00_RS34855	COG2197	response regulator
N6H00_RS34865	COG3321	synthase
N6H00_RS34865	COG0604	alcohol dehydrogenase
N6H00_RS34870	COG3321	synthase
N6H00_RS34870	COG0604	alcohol dehydrogenase
N6H00_RS34875	COG3321	synthase
N6H00_RS34875	COG0604	alcohol dehydrogenase
N6H00_RS34890	COG0477	Major facilitator Superfamily
N6H00_RS34900	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS34935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N6H00_RS34945	COG0456	acetyltransferase
N6H00_RS34965	COG1301	dicarboxylic acid transport
N6H00_RS34970	COG4948	Mandelate Racemase Muconate Lactonizing
N6H00_RS34990	COG0179	Fumarylacetoacetate (FAA) hydrolase
N6H00_RS34995	COG0596	Alpha beta hydrolase
N6H00_RS35000	COG0583	DNA-binding transcription factor activity
N6H00_RS35020	COG2828	Protein conserved in bacteria
N6H00_RS35030	COG0095	Lipoate-protein ligase
N6H00_RS35050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N6H00_RS35070	COG0142	geranyltranstransferase activity
N6H00_RS35090	COG0477	Major facilitator Superfamily
N6H00_RS35095	COG3835	regulator
N6H00_RS35100	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS35115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N6H00_RS35120	COG2815	serine threonine protein kinase
N6H00_RS35120	COG0515	serine threonine protein kinase
N6H00_RS35135	COG0395	ABC-type sugar transport system, permease component
N6H00_RS35140	COG1175	transmembrane transport
N6H00_RS35160	COG3507	Belongs to the glycosyl hydrolase 43 family
N6H00_RS35165	COG3119	arylsulfatase activity
N6H00_RS35190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N6H00_RS35220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N6H00_RS35225	COG2828	Protein conserved in bacteria
N6H00_RS35235	COG2814	Major facilitator Superfamily
N6H00_RS35245	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N6H00_RS35250	COG1309	transcriptional regulator
N6H00_RS35275	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS35285	COG0475	glutathione-regulated potassium exporter activity
N6H00_RS35300	COG0492	ferredoxin-NADP+ reductase activity
N6H00_RS35305	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS35335	COG0129	dihydroxy-acid dehydratase activity
N6H00_RS35340	COG0300	oxidoreductase activity
N6H00_RS35375	COG2226	methyltransferase
N6H00_RS35380	COG3835	regulator
N6H00_RS35400	COG2080	2 iron, 2 sulfur cluster binding
N6H00_RS35440	COG0701	Predicted permease
N6H00_RS35510	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS35545	COG0435	Glutathione S-transferase
N6H00_RS35610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N6H00_RS35640	COG1309	transcriptional regulator
N6H00_RS35705	COG4221	oxidoreductase activity
N6H00_RS35725	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS35735	COG1968	undecaprenyl-diphosphatase activity
N6H00_RS35745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N6H00_RS35750	COG1414	Transcriptional regulator
N6H00_RS35775	COG2610	gluconate transmembrane transporter activity
N6H00_RS35780	COG4948	Mandelate Racemase Muconate Lactonizing
N6H00_RS35795	COG3537	Alpha-1,2-mannosidase
N6H00_RS35805	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N6H00_RS35810	COG3387	PFAM Glycoside hydrolase 15-related
N6H00_RS35825	COG4336	lyase activity
N6H00_RS35830	COG0477	Major facilitator Superfamily
N6H00_RS35840	COG1984	allophanate hydrolase subunit 2
N6H00_RS35850	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N6H00_RS35855	COG1802	Transcriptional regulator
N6H00_RS35870	COG2197	response regulator
N6H00_RS35875	COG0668	transmembrane transport
N6H00_RS35880	COG0477	Major facilitator Superfamily
N6H00_RS35885	COG0739	heme binding
N6H00_RS35895	COG2508	Transcriptional regulator
N6H00_RS35905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N6H00_RS35910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N6H00_RS35935	COG0326	Molecular chaperone. Has ATPase activity
N6H00_RS35995	COG3250	beta-galactosidase activity
N6H00_RS36025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N6H00_RS36030	COG2080	2 iron, 2 sulfur cluster binding
N6H00_RS36035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N6H00_RS36040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N6H00_RS36045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS36100	COG3594	Acyltransferase
N6H00_RS36105	COG2376	Dihydroxyacetone kinase
N6H00_RS36110	COG2376	Dihydroxyacetone kinase
N6H00_RS36115	COG4221	oxidoreductase activity
N6H00_RS36125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N6H00_RS36135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N6H00_RS36145	COG4565	transcriptional regulatory protein
N6H00_RS36150	COG3290	protein histidine kinase activity
N6H00_RS36160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N6H00_RS36170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N6H00_RS36185	COG0726	polysaccharide deacetylase
N6H00_RS36190	COG0114	fumarate hydratase activity
N6H00_RS36195	COG2207	Transcriptional regulator
N6H00_RS36195	COG3708	Transcriptional regulator
N6H00_RS36205	COG2267	carboxylic ester hydrolase activity
N6H00_RS36220	COG3903	Transcriptional regulator
N6H00_RS36220	COG3629	intracellular signal transduction
N6H00_RS36225	COG2175	clavaminate synthase activity
N6H00_RS36240	COG0306	phosphate transporter
N6H00_RS36250	COG1357	PFAM Pentapeptide repeats (8 copies)
N6H00_RS36270	COG0583	DNA-binding transcription factor activity
N6H00_RS36335	COG3511	phospholipase C
N6H00_RS36380	COG1309	transcriptional regulator
N6H00_RS36405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6H00_RS36415	COG2050	protein possibly involved in aromatic compounds catabolism
N6H00_RS36425	COG0183	Belongs to the thiolase family
N6H00_RS36435	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS36440	COG3396	Phenylacetate-CoA oxygenase
N6H00_RS36445	COG3460	Phenylacetate-CoA oxygenase
N6H00_RS36450	COG3396	Phenylacetate-CoA oxygenase
N6H00_RS36455	COG2151	metal-sulfur cluster biosynthetic enzyme
N6H00_RS36460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N6H00_RS36475	COG0583	DNA-binding transcription factor activity
N6H00_RS36500	COG2267	carboxylic ester hydrolase activity
N6H00_RS36520	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS36525	COG0579	oxidoreductase
N6H00_RS36555	COG2356	endonuclease I
N6H00_RS36560	COG0328	RNA-DNA hybrid ribonuclease activity
N6H00_RS36565	COG2814	Major facilitator Superfamily
N6H00_RS36585	COG2755	lipolytic protein G-D-S-L family
N6H00_RS36590	COG0596	Alpha beta hydrolase
N6H00_RS36610	COG2706	6-phosphogluconolactonase activity
N6H00_RS36615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N6H00_RS36620	COG4948	Mandelate Racemase Muconate Lactonizing
N6H00_RS36625	COG0277	FAD linked oxidase domain protein
N6H00_RS36625	COG0247	lactate metabolic process
N6H00_RS36630	COG0028	Belongs to the TPP enzyme family
N6H00_RS36645	COG1846	Transcriptional regulator
N6H00_RS36705	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
N6H00_RS36730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS36740	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N6H00_RS36755	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
N6H00_RS36760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N6H00_RS36765	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N6H00_RS36775	COG0542	response to heat
N6H00_RS36795	COG1982	Orn Lys Arg decarboxylase major
N6H00_RS36810	COG2890	protein-(glutamine-N5) methyltransferase activity
N6H00_RS36825	COG1175	transmembrane transport
N6H00_RS36830	COG0395	ABC-type sugar transport system, permease component
N6H00_RS36850	COG1175	transmembrane transport
N6H00_RS36860	COG1063	alcohol dehydrogenase
N6H00_RS36885	COG0488	(ABC) transporter
N6H00_RS36890	COG0488	(ABC) transporter
N6H00_RS36905	COG0154	amidase activity
N6H00_RS36910	COG1309	transcriptional regulator
N6H00_RS36935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS36970	COG2318	DinB family
N6H00_RS36975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N6H00_RS36980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N6H00_RS36985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6H00_RS37005	COG0515	serine threonine protein kinase
N6H00_RS37020	COG0583	DNA-binding transcription factor activity
N6H00_RS37025	COG0183	Belongs to the thiolase family
N6H00_RS37035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N6H00_RS37045	COG0243	molybdopterin cofactor binding
N6H00_RS37075	COG2239	Acts as a magnesium transporter
N6H00_RS37100	COG1017	nitric oxide dioxygenase activity
N6H00_RS37100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N6H00_RS37105	COG0745	RESPONSE REGULATOR receiver
N6H00_RS37110	COG2205	protein histidine kinase activity
N6H00_RS37135	COG2205	protein histidine kinase activity
N6H00_RS37140	COG0745	RESPONSE REGULATOR receiver
N6H00_RS37155	COG0583	DNA-binding transcription factor activity
N6H00_RS37160	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS37165	COG1309	transcriptional regulator
N6H00_RS37170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N6H00_RS37175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6H00_RS37180	COG0765	amino acid transport
N6H00_RS37185	COG1126	abc transporter atp-binding protein
N6H00_RS37190	COG2814	Major facilitator Superfamily
N6H00_RS37200	COG2814	Major facilitator Superfamily
N6H00_RS37210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N6H00_RS37225	COG2376	Dihydroxyacetone kinase
N6H00_RS37230	COG0698	ribose 5-phosphate isomerase
N6H00_RS37240	COG0583	DNA-binding transcription factor activity
N6H00_RS37255	COG2186	Transcriptional regulator
N6H00_RS37270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N6H00_RS37280	COG1122	ATPase activity
N6H00_RS37285	COG1088	dTDP-glucose 4,6-dehydratase activity
N6H00_RS37300	COG3618	amidohydrolase
N6H00_RS37305	COG1737	Transcriptional regulator
N6H00_RS37310	COG2084	Dehydrogenase
N6H00_RS37335	COG0604	alcohol dehydrogenase
N6H00_RS37340	COG4977	sequence-specific DNA binding
N6H00_RS37355	COG0583	DNA-binding transcription factor activity
N6H00_RS37360	COG2197	response regulator
N6H00_RS37375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N6H00_RS37380	COG1846	Transcriptional regulator
N6H00_RS37390	COG0583	DNA-binding transcription factor activity
N6H00_RS37395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N6H00_RS37395	COG2124	cytochrome p450
N6H00_RS37405	COG1349	DNA-binding transcription factor activity
N6H00_RS37415	COG1175	transmembrane transport
N6H00_RS37420	COG3833	ABC-type maltose transport systems, permease component
N6H00_RS37445	COG0477	Major facilitator Superfamily
N6H00_RS37455	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS37465	COG0655	NAD(P)H dehydrogenase (quinone) activity
N6H00_RS37495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N6H00_RS37515	COG2301	Belongs to the HpcH HpaI aldolase family
N6H00_RS37535	COG1522	sequence-specific DNA binding
N6H00_RS37550	COG2409	Drug exporters of the RND superfamily
N6H00_RS37565	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS37580	COG0604	alcohol dehydrogenase
N6H00_RS37580	COG3321	synthase
N6H00_RS37585	COG3321	synthase
N6H00_RS37585	COG0604	alcohol dehydrogenase
N6H00_RS37590	COG0604	alcohol dehydrogenase
N6H00_RS37590	COG3321	synthase
N6H00_RS37630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N6H00_RS37630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N6H00_RS37645	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS37670	COG3266	domain, Protein
N6H00_RS37670	COG0515	serine threonine protein kinase
N6H00_RS37695	COG3251	PFAM MbtH domain protein
N6H00_RS37710	COG2124	cytochrome p450
N6H00_RS37730	COG0142	geranyltranstransferase activity
N6H00_RS37740	COG1053	succinate dehydrogenase
N6H00_RS37745	COG1063	alcohol dehydrogenase
N6H00_RS37755	COG1053	succinate dehydrogenase
N6H00_RS37765	COG0673	inositol 2-dehydrogenase activity
N6H00_RS37770	COG0477	Major facilitator Superfamily
N6H00_RS37775	COG0583	DNA-binding transcription factor activity
N6H00_RS37780	COG1053	succinate dehydrogenase
N6H00_RS37785	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS37795	COG1309	transcriptional regulator
N6H00_RS37820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N6H00_RS37855	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS37875	COG0583	DNA-binding transcription factor activity
N6H00_RS37885	COG1733	regulation of RNA biosynthetic process
N6H00_RS37890	COG2814	Major facilitator Superfamily
N6H00_RS37895	COG0066	3-isopropylmalate dehydratase activity
N6H00_RS37900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N6H00_RS37910	COG1522	sequence-specific DNA binding
N6H00_RS37930	COG2301	Belongs to the HpcH HpaI aldolase family
N6H00_RS37945	COG0148	phosphopyruvate hydratase activity
N6H00_RS37955	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS37960	COG3795	YCII-related domain
N6H00_RS37965	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS37970	COG1309	transcriptional regulator
N6H00_RS37985	COG1609	Transcriptional regulator
N6H00_RS37995	COG0395	ABC-type sugar transport system, permease component
N6H00_RS38005	COG4221	oxidoreductase activity
N6H00_RS38015	COG1309	transcriptional regulator
N6H00_RS38030	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N6H00_RS38040	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS38080	COG4221	oxidoreductase activity
N6H00_RS38095	COG1802	Transcriptional regulator
N6H00_RS38100	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N6H00_RS38105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N6H00_RS38115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N6H00_RS38120	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
N6H00_RS38140	COG3848	Pyruvate phosphate dikinase
N6H00_RS38140	COG0574	Belongs to the PEP-utilizing enzyme family
N6H00_RS38210	COG3321	synthase
N6H00_RS38210	COG0604	alcohol dehydrogenase
N6H00_RS38210	COG3321	synthase
N6H00_RS38210	COG0604	alcohol dehydrogenase
N6H00_RS38215	COG0604	alcohol dehydrogenase
N6H00_RS38215	COG3321	synthase
N6H00_RS38220	COG2423	ornithine cyclodeaminase activity
N6H00_RS38225	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6H00_RS38230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N6H00_RS38260	COG0583	DNA-binding transcription factor activity
N6H00_RS38290	COG2072	flavoprotein involved in K transport
N6H00_RS38315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N6H00_RS38325	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS38330	COG4977	sequence-specific DNA binding
N6H00_RS38350	COG1309	transcriptional regulator
N6H00_RS38370	COG1968	undecaprenyl-diphosphatase activity
N6H00_RS38395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N6H00_RS38415	COG0667	Aldo Keto reductase
N6H00_RS38435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N6H00_RS38470	COG1024	Enoyl-CoA hydratase
N6H00_RS38475	COG1024	Enoyl-CoA hydratase
N6H00_RS38495	COG1132	(ABC) transporter
N6H00_RS38515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N6H00_RS38535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N6H00_RS38545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N6H00_RS38550	COG1335	isochorismatase
N6H00_RS38575	COG1216	Glycosyl transferase, family 2
N6H00_RS38575	COG0438	transferase activity, transferring glycosyl groups
N6H00_RS38590	COG0477	Major facilitator Superfamily
N6H00_RS38605	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
N6H00_RS38610	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS38640	COG0277	FAD linked oxidase domain protein
N6H00_RS38645	COG3321	synthase
N6H00_RS38645	COG0604	alcohol dehydrogenase
N6H00_RS38645	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS38655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N6H00_RS38670	COG1960	acyl-CoA dehydrogenase activity
N6H00_RS38675	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
N6H00_RS38690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N6H00_RS38695	COG4948	Mandelate Racemase Muconate Lactonizing
N6H00_RS38700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N6H00_RS38705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N6H00_RS38715	COG0436	Aminotransferase
N6H00_RS38720	COG0477	Major facilitator Superfamily
N6H00_RS38730	COG0656	L-ascorbic acid biosynthetic process
N6H00_RS38740	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS38750	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS38755	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS38760	COG1063	alcohol dehydrogenase
N6H00_RS38765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N6H00_RS38770	COG2084	Dehydrogenase
N6H00_RS38780	COG4221	oxidoreductase activity
N6H00_RS38820	COG2072	flavoprotein involved in K transport
N6H00_RS38900	COG0464	growth
N6H00_RS38925	COG1473	amidohydrolase
N6H00_RS38950	COG0667	Aldo Keto reductase
N6H00_RS38955	COG3321	synthase
N6H00_RS38955	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS38955	COG0604	alcohol dehydrogenase
N6H00_RS38965	COG2124	cytochrome p450
N6H00_RS38975	COG0477	Major facilitator Superfamily
N6H00_RS38985	COG1902	pentaerythritol trinitrate reductase activity
N6H00_RS39005	COG0154	amidase activity
N6H00_RS39030	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS39070	COG1064	alcohol dehydrogenase
N6H00_RS39110	COG5520	Belongs to the glycosyl hydrolase 30 family
N6H00_RS39115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N6H00_RS39130	COG0477	Major facilitator Superfamily
N6H00_RS39135	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS39175	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS39180	COG1309	transcriptional regulator
N6H00_RS39215	COG2188	Transcriptional regulator
N6H00_RS39220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N6H00_RS39225	COG0028	Belongs to the TPP enzyme family
N6H00_RS39235	COG0477	Major facilitator Superfamily
N6H00_RS39250	COG2271	Major facilitator Superfamily
N6H00_RS39285	COG0529	Catalyzes the synthesis of activated sulfate
N6H00_RS39290	COG1959	2 iron, 2 sulfur cluster binding
N6H00_RS39295	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS39340	COG0431	NADPH-dependent FMN reductase
N6H00_RS39350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N6H00_RS39365	COG0604	alcohol dehydrogenase
N6H00_RS39365	COG3321	synthase
N6H00_RS39370	COG2986	histidine ammonia-lyase
N6H00_RS39375	COG1022	Amp-dependent synthetase and ligase
N6H00_RS39375	COG3320	Male sterility
N6H00_RS39385	COG3629	intracellular signal transduction
N6H00_RS39390	COG3903	Transcriptional regulator
N6H00_RS39390	COG3629	intracellular signal transduction
N6H00_RS39395	COG3321	synthase
N6H00_RS39395	COG0604	alcohol dehydrogenase
N6H00_RS39400	COG0604	alcohol dehydrogenase
N6H00_RS39400	COG3321	synthase
N6H00_RS39460	COG3938	Belongs to the proline racemase family
N6H00_RS39475	COG1802	Transcriptional regulator
N6H00_RS39485	COG1695	Transcriptional regulator
N6H00_RS39500	COG0142	geranyltranstransferase activity
N6H00_RS39505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N6H00_RS39515	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N6H00_RS39595	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS39605	COG0318	PFAM AMP-dependent synthetase and ligase
N6H00_RS39615	COG1309	transcriptional regulator
N6H00_RS39635	COG0395	ABC-type sugar transport system, permease component
N6H00_RS39640	COG1175	transmembrane transport
N6H00_RS39650	COG1940	carbohydrate kinase activity
N6H00_RS39655	COG1505	serine-type exopeptidase activity
N6H00_RS39685	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N6H00_RS39725	COG0604	alcohol dehydrogenase
N6H00_RS39725	COG3321	synthase
N6H00_RS39745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N6H00_RS39755	COG4569	acetaldehyde dehydrogenase (acetylating) activity
N6H00_RS39785	COG0165	Argininosuccinate lyase
N6H00_RS39795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N6H00_RS39805	COG3424	synthase
N6H00_RS39810	COG1024	Enoyl-CoA hydratase
N6H00_RS39815	COG1024	Enoyl-CoA hydratase
N6H00_RS39855	COG2124	cytochrome p450
N6H00_RS39860	COG1012	belongs to the aldehyde dehydrogenase family
N6H00_RS39870	COG0488	(ABC) transporter
N6H00_RS39875	COG1028	Short-chain dehydrogenase reductase Sdr
N6H00_RS39895	COG2226	methyltransferase
N6H00_RS39895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N6H00_RS39895	COG3433	isochorismatase activity