locus-tag	class	description
D7Y56_RS00090	COG2267	carboxylic ester hydrolase activity
D7Y56_RS00090	COG2226	methyltransferase
D7Y56_RS00265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D7Y56_RS00270	COG2226	methyltransferase
D7Y56_RS00370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D7Y56_RS00440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D7Y56_RS00445	COG1518	maintenance of DNA repeat elements
D7Y56_RS00490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D7Y56_RS00515	COG1192	Involved in chromosome partitioning
D7Y56_RS00595	COG0523	cobalamin synthesis protein
D7Y56_RS00635	COG3647	Membrane
D7Y56_RS00715	COG1902	pentaerythritol trinitrate reductase activity
D7Y56_RS00820	COG1857	crispr-associated protein
D7Y56_RS00870	COG0529	Catalyzes the synthesis of activated sulfate
D7Y56_RS00920	COG3883	PFAM NLP P60 protein
D7Y56_RS00920	COG0791	NLP P60 protein
D7Y56_RS00960	COG1192	Involved in chromosome partitioning
D7Y56_RS01000	COG4152	abc transporter atp-binding protein
D7Y56_RS01095	COG2801	Transposase and inactivated derivatives
D7Y56_RS01165	COG1475	DNA binding
D7Y56_RS01185	COG0456	acetyltransferase
D7Y56_RS01200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS01215	COG0019	diaminopimelate decarboxylase activity
D7Y56_RS01470	COG0586	Pfam SNARE associated Golgi protein
D7Y56_RS01495	COG3940	Belongs to the glycosyl hydrolase 43 family
D7Y56_RS01585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7Y56_RS01590	COG1120	ATPase activity
D7Y56_RS01625	COG1191	sigma factor activity
D7Y56_RS01645	COG2261	transglycosylase associated protein
D7Y56_RS01665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D7Y56_RS01700	COG3511	phospholipase C
D7Y56_RS01725	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D7Y56_RS01740	COG1891	lyase activity
D7Y56_RS01755	COG0300	oxidoreductase activity
D7Y56_RS01760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D7Y56_RS01770	COG4106	trans-aconitate 2-methyltransferase activity
D7Y56_RS01790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D7Y56_RS01795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7Y56_RS01800	COG1113	amino acid transport
D7Y56_RS01845	COG2259	Doxx family
D7Y56_RS01855	COG4977	sequence-specific DNA binding
D7Y56_RS01875	COG0346	lactoylglutathione lyase activity
D7Y56_RS01885	COG4941	Belongs to the sigma-70 factor family
D7Y56_RS01890	COG3795	YCII-related domain
D7Y56_RS01900	COG2814	Major facilitator Superfamily
D7Y56_RS01910	COG1278	Cold shock
D7Y56_RS01920	COG0584	glycerophosphoryl diester phosphodiesterase
D7Y56_RS02030	COG1349	DNA-binding transcription factor activity
D7Y56_RS02045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7Y56_RS02080	COG5297	Belongs to the glycosyl hydrolase family 6
D7Y56_RS02080	COG4733	cellulase activity
D7Y56_RS02085	COG5297	Belongs to the glycosyl hydrolase family 6
D7Y56_RS02100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7Y56_RS02160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7Y56_RS02190	COG0596	Alpha beta hydrolase
D7Y56_RS02210	COG0318	PFAM AMP-dependent synthetase and ligase
D7Y56_RS02215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D7Y56_RS02240	COG0515	serine threonine protein kinase
D7Y56_RS02240	COG2815	serine threonine protein kinase
D7Y56_RS02250	COG2813	Specifically methylates the guanine in position
D7Y56_RS02260	COG2356	endonuclease I
D7Y56_RS02265	COG2066	Belongs to the glutaminase family
D7Y56_RS02265	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D7Y56_RS02280	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D7Y56_RS02295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D7Y56_RS02300	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D7Y56_RS02305	COG2080	2 iron, 2 sulfur cluster binding
D7Y56_RS02315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7Y56_RS02360	COG2365	Tyrosine phosphatase family
D7Y56_RS02370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D7Y56_RS02390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D7Y56_RS02400	COG0438	transferase activity, transferring glycosyl groups
D7Y56_RS02400	COG0297	glycogen (starch) synthase activity
D7Y56_RS02425	COG0438	transferase activity, transferring glycosyl groups
D7Y56_RS02445	COG2304	oxidoreductase activity
D7Y56_RS02495	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS02500	COG5002	protein histidine kinase activity
D7Y56_RS02510	COG2376	Dihydroxyacetone kinase
D7Y56_RS02515	COG1461	Dihydroxyacetone kinase
D7Y56_RS02535	COG0488	(ABC) transporter
D7Y56_RS02550	COG1191	sigma factor activity
D7Y56_RS02565	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D7Y56_RS02615	COG1120	ATPase activity
D7Y56_RS02620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS02640	COG0254	rRNA binding
D7Y56_RS02655	COG1295	ribonuclease BN
D7Y56_RS02655	COG1959	2 iron, 2 sulfur cluster binding
D7Y56_RS02665	COG0366	Alpha amylase catalytic
D7Y56_RS02670	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS02675	COG1175	transmembrane transport
D7Y56_RS02685	COG5297	Belongs to the glycosyl hydrolase family 6
D7Y56_RS02685	COG4733	cellulase activity
D7Y56_RS02695	COG3250	beta-galactosidase activity
D7Y56_RS02705	COG1653	transport
D7Y56_RS02710	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS02725	COG1874	Beta-galactosidase
D7Y56_RS02725	COG0366	Alpha amylase catalytic
D7Y56_RS02735	COG1609	Transcriptional regulator
D7Y56_RS02740	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7Y56_RS02750	COG1129	ABC transporter
D7Y56_RS02755	COG1879	ABC-type sugar transport system periplasmic component
D7Y56_RS02775	COG1609	Transcriptional regulator
D7Y56_RS02785	COG0583	DNA-binding transcription factor activity
D7Y56_RS02795	COG3537	Alpha-1,2-mannosidase
D7Y56_RS02800	COG1505	serine-type exopeptidase activity
D7Y56_RS02810	COG3401	FG-GAP repeat protein
D7Y56_RS02835	COG0328	RNA-DNA hybrid ribonuclease activity
D7Y56_RS02840	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS02870	COG1063	alcohol dehydrogenase
D7Y56_RS02890	COG1349	DNA-binding transcription factor activity
D7Y56_RS02905	COG1073	alpha beta
D7Y56_RS02905	COG2226	methyltransferase
D7Y56_RS02910	COG3290	protein histidine kinase activity
D7Y56_RS02915	COG2409	Drug exporters of the RND superfamily
D7Y56_RS02930	COG1755	Isoprenylcysteine carboxyl methyltransferase
D7Y56_RS02945	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS02950	COG1175	transmembrane transport
D7Y56_RS03010	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D7Y56_RS03015	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D7Y56_RS03020	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D7Y56_RS03045	COG0024	Methionine aminopeptidase
D7Y56_RS03100	COG0714	Associated with various cellular activities
D7Y56_RS03130	COG2197	response regulator
D7Y56_RS03155	COG3548	integral membrane protein
D7Y56_RS03175	COG0235	Class ii aldolase
D7Y56_RS03180	COG3395	kinase activity
D7Y56_RS03195	COG1349	DNA-binding transcription factor activity
D7Y56_RS03210	COG0494	nUDIX hydrolase
D7Y56_RS03225	COG0488	(ABC) transporter
D7Y56_RS03230	COG0385	Bile acid
D7Y56_RS03250	COG0142	geranyltranstransferase activity
D7Y56_RS03270	COG1175	transmembrane transport
D7Y56_RS03275	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS03300	COG2205	protein histidine kinase activity
D7Y56_RS03300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7Y56_RS03310	COG2172	sigma factor antagonist activity
D7Y56_RS03315	COG1366	Belongs to the anti-sigma-factor antagonist family
D7Y56_RS03320	COG1366	Belongs to the anti-sigma-factor antagonist family
D7Y56_RS03340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D7Y56_RS03380	COG1349	DNA-binding transcription factor activity
D7Y56_RS03420	COG1940	carbohydrate kinase activity
D7Y56_RS03455	COG0445	tRNA wobble uridine modification
D7Y56_RS03465	COG0494	nUDIX hydrolase
D7Y56_RS03485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D7Y56_RS03525	COG0584	glycerophosphoryl diester phosphodiesterase
D7Y56_RS03545	COG0671	phosphoesterase, PA-phosphatase related
D7Y56_RS03580	COG1902	pentaerythritol trinitrate reductase activity
D7Y56_RS03590	COG1472	Belongs to the glycosyl hydrolase 3 family
D7Y56_RS03600	COG1175	transmembrane transport
D7Y56_RS03610	COG1609	Transcriptional regulator
D7Y56_RS03615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7Y56_RS03640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D7Y56_RS03655	COG2706	6-phosphogluconolactonase activity
D7Y56_RS03675	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS03685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D7Y56_RS03690	COG2815	serine threonine protein kinase
D7Y56_RS03690	COG0515	serine threonine protein kinase
D7Y56_RS03695	COG0667	Aldo Keto reductase
D7Y56_RS03790	COG1349	DNA-binding transcription factor activity
D7Y56_RS03805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D7Y56_RS03810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D7Y56_RS03820	COG0254	rRNA binding
D7Y56_RS03830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D7Y56_RS03840	COG1263	PTS System
D7Y56_RS03840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7Y56_RS03845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D7Y56_RS03860	COG2186	Transcriptional regulator
D7Y56_RS03865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7Y56_RS03875	COG4948	Mandelate Racemase Muconate Lactonizing
D7Y56_RS03890	COG0444	Belongs to the ABC transporter superfamily
D7Y56_RS03895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7Y56_RS03900	COG0601	transmembrane transport
D7Y56_RS03905	COG0747	negative chemotaxis
D7Y56_RS03930	COG0456	acetyltransferase
D7Y56_RS03935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7Y56_RS03960	COG1309	transcriptional regulator
D7Y56_RS03995	COG0739	heme binding
D7Y56_RS04025	COG1408	metallophosphoesterase
D7Y56_RS04030	COG1132	(ABC) transporter
D7Y56_RS04040	COG0277	FAD linked oxidase domain protein
D7Y56_RS04045	COG1132	(ABC) transporter
D7Y56_RS04050	COG1132	(ABC) transporter
D7Y56_RS04060	COG1793	dna ligase
D7Y56_RS04075	COG1946	Acyl-CoA thioesterase
D7Y56_RS04110	COG0386	Belongs to the glutathione peroxidase family
D7Y56_RS04125	COG0242	peptide deformylase activity
D7Y56_RS04135	COG3442	glutamine amidotransferase
D7Y56_RS04140	COG0205	6-phosphofructokinase activity
D7Y56_RS04165	COG0204	Acyl-transferase
D7Y56_RS04185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D7Y56_RS04195	COG0804	urea catabolic process
D7Y56_RS04200	COG0832	Belongs to the urease beta subunit family
D7Y56_RS04205	COG0831	urea catabolic process
D7Y56_RS04210	COG1309	transcriptional regulator
D7Y56_RS04225	COG0740	serine-type endopeptidase activity
D7Y56_RS04245	COG0156	8-amino-7-oxononanoate synthase activity
D7Y56_RS04250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D7Y56_RS04255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D7Y56_RS04260	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D7Y56_RS04310	COG1595	DNA-templated transcription, initiation
D7Y56_RS04335	COG1063	alcohol dehydrogenase
D7Y56_RS04355	COG0516	GMP reductase activity
D7Y56_RS04355	COG0517	IMP dehydrogenase activity
D7Y56_RS04380	COG0589	response to stress
D7Y56_RS04385	COG0517	IMP dehydrogenase activity
D7Y56_RS04385	COG0516	GMP reductase activity
D7Y56_RS04405	COG2239	Acts as a magnesium transporter
D7Y56_RS04415	COG0702	epimerase
D7Y56_RS04435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D7Y56_RS04460	COG4585	Histidine kinase
D7Y56_RS04465	COG2197	response regulator
D7Y56_RS04470	COG1940	carbohydrate kinase activity
D7Y56_RS04475	COG2188	Transcriptional regulator
D7Y56_RS04480	COG1595	DNA-templated transcription, initiation
D7Y56_RS04500	COG0626	cystathionine gamma-synthase activity
D7Y56_RS04525	COG1522	sequence-specific DNA binding
D7Y56_RS04530	COG0419	ATPase involved in DNA repair
D7Y56_RS04535	COG0420	3'-5' exonuclease activity
D7Y56_RS04540	COG1739	Uncharacterized protein family UPF0029
D7Y56_RS04545	COG1832	CoA-binding protein
D7Y56_RS04605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7Y56_RS04630	COG1968	undecaprenyl-diphosphatase activity
D7Y56_RS04635	COG0243	molybdopterin cofactor binding
D7Y56_RS04645	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D7Y56_RS04655	COG2318	DinB family
D7Y56_RS04665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D7Y56_RS04695	COG2770	Histidine kinase
D7Y56_RS04695	COG2208	phosphoserine phosphatase activity
D7Y56_RS04700	COG0640	Transcriptional regulator
D7Y56_RS04715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7Y56_RS04730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7Y56_RS04740	COG2124	cytochrome p450
D7Y56_RS04760	COG0697	spore germination
D7Y56_RS04815	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D7Y56_RS04815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D7Y56_RS04825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D7Y56_RS04845	COG1716	ATPase activity
D7Y56_RS04865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D7Y56_RS04900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D7Y56_RS04910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7Y56_RS04925	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D7Y56_RS04945	COG2018	Roadblock/LC7 domain
D7Y56_RS05015	COG2364	Membrane
D7Y56_RS05025	COG2270	Major facilitator Superfamily
D7Y56_RS05035	COG3030	protein affecting phage T7 exclusion by the F plasmid
D7Y56_RS05040	COG1216	Glycosyl transferase, family 2
D7Y56_RS05065	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS05105	COG0783	Belongs to the Dps family
D7Y56_RS05140	COG4555	ABC transporter
D7Y56_RS05215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D7Y56_RS05220	COG0140	phosphoribosyl-ATP diphosphatase activity
D7Y56_RS05225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D7Y56_RS05230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D7Y56_RS05230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D7Y56_RS05235	COG3201	nicotinamide mononucleotide transporter
D7Y56_RS05250	COG1940	carbohydrate kinase activity
D7Y56_RS05250	COG1846	Transcriptional regulator
D7Y56_RS05255	COG0738	Major facilitator superfamily
D7Y56_RS05260	COG2233	PERMEase
D7Y56_RS05270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D7Y56_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS05295	COG2390	Transcriptional regulator
D7Y56_RS05300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D7Y56_RS05305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7Y56_RS05310	COG4521	taurine ABC transporter
D7Y56_RS05330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D7Y56_RS05345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D7Y56_RS05355	COG1758	RNA polymerase activity
D7Y56_RS05370	COG0284	orotidine-5'-phosphate decarboxylase activity
D7Y56_RS05375	COG0167	dihydroorotate dehydrogenase activity
D7Y56_RS05380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D7Y56_RS05385	COG0505	Belongs to the CarA family
D7Y56_RS05395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7Y56_RS05400	COG0540	Belongs to the ATCase OTCase family
D7Y56_RS05405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D7Y56_RS05415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7Y56_RS05420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D7Y56_RS05425	COG0006	proline dipeptidase activity
D7Y56_RS05435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D7Y56_RS05440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D7Y56_RS05445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D7Y56_RS05450	COG0739	heme binding
D7Y56_RS05455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7Y56_RS05460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D7Y56_RS05465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D7Y56_RS05470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D7Y56_RS05490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D7Y56_RS05510	COG0124	histidyl-tRNA synthetase
D7Y56_RS05525	COG1196	nuclear chromosome segregation
D7Y56_RS05530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D7Y56_RS05535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D7Y56_RS05540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7Y56_RS05545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7Y56_RS05555	COG2255	four-way junction helicase activity
D7Y56_RS05560	COG0632	four-way junction helicase activity
D7Y56_RS05565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D7Y56_RS05570	COG0217	transcriptional regulatory protein
D7Y56_RS05575	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D7Y56_RS05580	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D7Y56_RS05590	COG0438	transferase activity, transferring glycosyl groups
D7Y56_RS05595	COG1560	Kdo2-lipid A biosynthetic process
D7Y56_RS05600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D7Y56_RS05615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7Y56_RS05630	COG0667	Aldo Keto reductase
D7Y56_RS05635	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D7Y56_RS05655	COG0318	PFAM AMP-dependent synthetase and ligase
D7Y56_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS05700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7Y56_RS05710	COG3321	synthase
D7Y56_RS05710	COG4221	oxidoreductase activity
D7Y56_RS05710	COG0604	alcohol dehydrogenase
D7Y56_RS05710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS05720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7Y56_RS05725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D7Y56_RS05740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D7Y56_RS05765	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS05770	COG1175	transmembrane transport
D7Y56_RS05800	COG1609	Transcriptional regulator
D7Y56_RS05815	COG0454	-acetyltransferase
D7Y56_RS05815	COG0456	acetyltransferase
D7Y56_RS05825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D7Y56_RS05885	COG4585	Histidine kinase
D7Y56_RS05890	COG2197	response regulator
D7Y56_RS05900	COG1648	precorrin-2 dehydrogenase activity
D7Y56_RS05900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D7Y56_RS05905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D7Y56_RS05920	COG1464	Belongs to the NlpA lipoprotein family
D7Y56_RS05925	COG2011	ABC-type metal ion transport system permease component
D7Y56_RS05965	COG0477	Major facilitator Superfamily
D7Y56_RS05985	COG0165	Argininosuccinate lyase
D7Y56_RS05995	COG1438	arginine binding
D7Y56_RS06000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D7Y56_RS06005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D7Y56_RS06010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D7Y56_RS06015	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D7Y56_RS06040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D7Y56_RS06055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7Y56_RS06060	COG0697	spore germination
D7Y56_RS06070	COG1649	PFAM Uncharacterised BCR, COG1649
D7Y56_RS06080	COG1116	anion transmembrane transporter activity
D7Y56_RS06085	COG0494	nUDIX hydrolase
D7Y56_RS06095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7Y56_RS06095	COG0072	phenylalanine-tRNA ligase activity
D7Y56_RS06100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D7Y56_RS06105	COG5002	protein histidine kinase activity
D7Y56_RS06110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7Y56_RS06115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D7Y56_RS06120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D7Y56_RS06125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D7Y56_RS06170	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS06175	COG0174	glutamine synthetase
D7Y56_RS06205	COG4176	ABC-type proline glycine betaine transport system permease component
D7Y56_RS06225	COG1595	DNA-templated transcription, initiation
D7Y56_RS06250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D7Y56_RS06255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D7Y56_RS06295	COG0805	protein transport
D7Y56_RS06300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7Y56_RS06320	COG2378	regulation of single-species biofilm formation
D7Y56_RS06330	COG0545	Peptidyl-prolyl cis-trans isomerase
D7Y56_RS06335	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D7Y56_RS06345	COG1609	Transcriptional regulator
D7Y56_RS06350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D7Y56_RS06355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D7Y56_RS06370	COG4122	O-methyltransferase activity
D7Y56_RS06375	COG1222	aaa ATPase
D7Y56_RS06395	COG1994	Peptidase M50
D7Y56_RS06395	COG0517	IMP dehydrogenase activity
D7Y56_RS06405	COG2197	response regulator
D7Y56_RS06410	COG4166	transmembrane transport
D7Y56_RS06420	COG1410	methionine synthase
D7Y56_RS06420	COG0646	methionine synthase
D7Y56_RS06425	COG1414	Transcriptional regulator
D7Y56_RS06430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D7Y56_RS06435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D7Y56_RS06440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D7Y56_RS06445	COG2186	Transcriptional regulator
D7Y56_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS06455	COG4948	Mandelate Racemase Muconate Lactonizing
D7Y56_RS06485	COG0598	Magnesium transport protein CorA
D7Y56_RS06495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7Y56_RS06500	COG0667	Aldo Keto reductase
D7Y56_RS06530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7Y56_RS06540	COG0564	pseudouridine synthase activity
D7Y56_RS06555	COG2186	Transcriptional regulator
D7Y56_RS06560	COG3265	gluconokinase activity
D7Y56_RS06605	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D7Y56_RS06610	COG2149	membrane
D7Y56_RS06630	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS06635	COG2234	aminopeptidase activity
D7Y56_RS06635	COG4935	Belongs to the peptidase S8 family
D7Y56_RS06645	COG0318	PFAM AMP-dependent synthetase and ligase
D7Y56_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS06655	COG3876	Protein conserved in bacteria
D7Y56_RS06670	COG0789	Transcriptional regulator
D7Y56_RS06690	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS06700	COG0640	Transcriptional regulator
D7Y56_RS06725	COG2851	Citrate transporter
D7Y56_RS06735	COG1309	transcriptional regulator
D7Y56_RS06740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D7Y56_RS06745	COG2188	Transcriptional regulator
D7Y56_RS06760	COG0515	serine threonine protein kinase
D7Y56_RS06765	COG2755	lipolytic protein G-D-S-L family
D7Y56_RS06780	COG1725	Transcriptional regulator
D7Y56_RS06795	COG0346	lactoylglutathione lyase activity
D7Y56_RS06815	COG4565	transcriptional regulatory protein
D7Y56_RS06820	COG3540	Alkaline phosphatase
D7Y56_RS06835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D7Y56_RS06840	COG0587	DNA-directed DNA polymerase activity
D7Y56_RS06950	COG0641	radical SAM
D7Y56_RS06990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7Y56_RS06995	COG1126	abc transporter atp-binding protein
D7Y56_RS07010	COG0765	amino acid transport
D7Y56_RS07015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7Y56_RS07025	COG1799	cell septum assembly
D7Y56_RS07030	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS07035	COG0477	Major facilitator Superfamily
D7Y56_RS07040	COG0671	phosphoesterase, PA-phosphatase related
D7Y56_RS07050	COG0438	transferase activity, transferring glycosyl groups
D7Y56_RS07065	COG1160	GTP binding
D7Y56_RS07075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D7Y56_RS07105	COG3541	Predicted nucleotidyltransferase
D7Y56_RS07115	COG0494	nUDIX hydrolase
D7Y56_RS07130	COG1187	pseudouridine synthase activity
D7Y56_RS07135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D7Y56_RS07140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D7Y56_RS07155	COG0686	Belongs to the AlaDH PNT family
D7Y56_RS07165	COG0494	nUDIX hydrolase
D7Y56_RS07170	COG0504	CTP synthase activity
D7Y56_RS07175	COG3387	PFAM Glycoside hydrolase 15-related
D7Y56_RS07200	COG0297	glycogen (starch) synthase activity
D7Y56_RS07205	COG0497	DNA recombination
D7Y56_RS07210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D7Y56_RS07230	COG1120	ATPase activity
D7Y56_RS07235	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS07240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS07245	COG0647	UMP catabolic process
D7Y56_RS07280	COG2094	Belongs to the DNA glycosylase MPG family
D7Y56_RS07290	COG1881	PFAM PEBP family protein
D7Y56_RS07315	COG1119	ATPase activity
D7Y56_RS07325	COG2197	response regulator
D7Y56_RS07340	COG1131	(ABC) transporter
D7Y56_RS07340	COG1716	ATPase activity
D7Y56_RS07340	COG0842	Transport permease protein
D7Y56_RS07345	COG3830	Belongs to the UPF0237 family
D7Y56_RS07345	COG0560	Phosphoserine phosphatase
D7Y56_RS07365	COG2807	transmembrane transport
D7Y56_RS07370	COG2186	Transcriptional regulator
D7Y56_RS07400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D7Y56_RS07420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D7Y56_RS07425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7Y56_RS07460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D7Y56_RS07475	COG3387	PFAM Glycoside hydrolase 15-related
D7Y56_RS07525	COG0488	(ABC) transporter
D7Y56_RS07545	COG0235	Class ii aldolase
D7Y56_RS07560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D7Y56_RS07565	COG1492	cobalamin metabolic process
D7Y56_RS07580	COG1797	cobyrinic acid a,c-diamide synthase activity
D7Y56_RS07605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D7Y56_RS07620	COG1917	Cupin 2, conserved barrel domain protein
D7Y56_RS07650	COG1175	transmembrane transport
D7Y56_RS07655	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS07670	COG1902	pentaerythritol trinitrate reductase activity
D7Y56_RS07705	COG1414	Transcriptional regulator
D7Y56_RS07710	COG0768	penicillin binding
D7Y56_RS07715	COG2252	PERMEase
D7Y56_RS07740	COG4677	pectinesterase activity
D7Y56_RS07745	COG3866	Pectate lyase
D7Y56_RS07750	COG2755	lipolytic protein G-D-S-L family
D7Y56_RS07775	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS07795	COG1802	Transcriptional regulator
D7Y56_RS07805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7Y56_RS07810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7Y56_RS07850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7Y56_RS07855	COG2171	N-acyltransferase activity
D7Y56_RS07860	COG3226	Transcriptional regulator
D7Y56_RS07865	COG2076	Multidrug Resistance protein
D7Y56_RS07885	COG0822	iron-sulfur transferase activity
D7Y56_RS07890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7Y56_RS07895	COG0396	ATPase activity
D7Y56_RS07905	COG0719	Fe-S assembly protein
D7Y56_RS07940	COG0109	protoheme IX farnesyltransferase activity
D7Y56_RS07950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D7Y56_RS07965	COG0363	glucosamine-6-phosphate deaminase activity
D7Y56_RS07980	COG0166	Belongs to the GPI family
D7Y56_RS07990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D7Y56_RS07995	COG0149	triose-phosphate isomerase activity
D7Y56_RS08000	COG0126	phosphoglycerate kinase activity
D7Y56_RS08005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D7Y56_RS08010	COG1481	regulation of sporulation
D7Y56_RS08015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D7Y56_RS08020	COG1660	Displays ATPase and GTPase activities
D7Y56_RS08025	COG0322	excinuclease ABC activity
D7Y56_RS08035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D7Y56_RS08065	COG0556	nucleotide-excision repair
D7Y56_RS08075	COG0584	glycerophosphoryl diester phosphodiesterase
D7Y56_RS08080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D7Y56_RS08105	COG0436	Aminotransferase
D7Y56_RS08130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D7Y56_RS08135	COG0330	HflC and HflK could
D7Y56_RS08165	COG0237	dephospho-CoA kinase activity
D7Y56_RS08180	COG2226	methyltransferase
D7Y56_RS08185	COG1643	Atp-dependent helicase
D7Y56_RS08195	COG1309	transcriptional regulator
D7Y56_RS08220	COG2050	protein possibly involved in aromatic compounds catabolism
D7Y56_RS08240	COG0411	ABC transporter
D7Y56_RS08265	COG0737	Belongs to the 5'-nucleotidase family
D7Y56_RS08285	COG0287	Prephenate dehydrogenase
D7Y56_RS08285	COG1605	Chorismate mutase
D7Y56_RS08310	COG1278	Cold shock
D7Y56_RS08315	COG1309	transcriptional regulator
D7Y56_RS08325	COG0705	Rhomboid family
D7Y56_RS08330	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D7Y56_RS08340	COG0070	glutamate synthase
D7Y56_RS08340	COG0067	glutamate synthase
D7Y56_RS08340	COG0069	glutamate synthase activity
D7Y56_RS08375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7Y56_RS08380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7Y56_RS08385	COG2301	Belongs to the HpcH HpaI aldolase family
D7Y56_RS08390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D7Y56_RS08400	COG0159	tryptophan synthase activity
D7Y56_RS08405	COG0133	tryptophan synthase activity
D7Y56_RS08415	COG0134	indole-3-glycerol-phosphate synthase activity
D7Y56_RS08440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D7Y56_RS08450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7Y56_RS08455	COG2508	Transcriptional regulator
D7Y56_RS08475	COG2755	lipolytic protein G-D-S-L family
D7Y56_RS08485	COG0107	imidazoleglycerol-phosphate synthase activity
D7Y56_RS08490	COG0251	oxidation-reduction process
D7Y56_RS08495	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D7Y56_RS08500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D7Y56_RS08505	COG0131	Imidazoleglycerol-phosphate dehydratase
D7Y56_RS08510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D7Y56_RS08515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D7Y56_RS08540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D7Y56_RS08565	COG1432	Conserved Protein
D7Y56_RS08570	COG0587	DNA-directed DNA polymerase activity
D7Y56_RS08610	COG2153	protein acetylation
D7Y56_RS08620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D7Y56_RS08635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D7Y56_RS08640	COG3599	regulation of cell shape
D7Y56_RS08650	COG1799	cell septum assembly
D7Y56_RS08655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D7Y56_RS08675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D7Y56_RS08680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D7Y56_RS08690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D7Y56_RS08695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D7Y56_RS08705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D7Y56_RS08710	COG0768	penicillin binding
D7Y56_RS08720	COG0275	rRNA processing
D7Y56_RS08730	COG0714	Associated with various cellular activities
D7Y56_RS08750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D7Y56_RS08760	COG1121	(ABC) transporter
D7Y56_RS08765	COG1511	domain protein
D7Y56_RS08780	COG1233	COG1233 Phytoene dehydrogenase and related
D7Y56_RS08795	COG0352	thiamine-phosphate diphosphorylase activity
D7Y56_RS08815	COG2022	thiamine diphosphate biosynthetic process
D7Y56_RS08815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7Y56_RS08825	COG2022	thiamine diphosphate biosynthetic process
D7Y56_RS08830	COG0515	serine threonine protein kinase
D7Y56_RS08830	COG2815	serine threonine protein kinase
D7Y56_RS08835	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D7Y56_RS08840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D7Y56_RS08845	COG2193	ferroxidase activity
D7Y56_RS08855	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D7Y56_RS08870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7Y56_RS08875	COG2197	response regulator
D7Y56_RS08905	COG1940	carbohydrate kinase activity
D7Y56_RS08915	COG0003	Pfam Anion-transporting ATPase
D7Y56_RS08980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7Y56_RS08985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D7Y56_RS08990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D7Y56_RS08995	COG0723	plastoquinol--plastocyanin reductase activity
D7Y56_RS09000	COG2010	Cytochrome c
D7Y56_RS09005	COG1845	cytochrome c oxidase, subunit III
D7Y56_RS09015	COG1376	ErfK ybiS ycfS ynhG family protein
D7Y56_RS09025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D7Y56_RS09035	COG1104	cysteine desulfurase activity
D7Y56_RS09040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7Y56_RS09060	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D7Y56_RS09065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D7Y56_RS09070	COG2197	response regulator
D7Y56_RS09075	COG4585	Histidine kinase
D7Y56_RS09095	COG4106	trans-aconitate 2-methyltransferase activity
D7Y56_RS09100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7Y56_RS09115	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D7Y56_RS09125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D7Y56_RS09130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D7Y56_RS09135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7Y56_RS09140	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7Y56_RS09150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D7Y56_RS09185	COG0321	lipoyl(octanoyl) transferase activity
D7Y56_RS09190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D7Y56_RS09260	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS09265	COG4585	Histidine kinase
D7Y56_RS09270	COG2197	response regulator
D7Y56_RS09340	COG0789	Transcriptional regulator
D7Y56_RS09350	COG1595	DNA-templated transcription, initiation
D7Y56_RS09365	COG0366	Alpha amylase catalytic
D7Y56_RS09370	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS09385	COG1609	Transcriptional regulator
D7Y56_RS09395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D7Y56_RS09400	COG2890	protein-(glutamine-N5) methyltransferase activity
D7Y56_RS09410	COG0738	Major facilitator superfamily
D7Y56_RS09415	COG0174	glutamine synthetase
D7Y56_RS09435	COG2132	Multicopper oxidase
D7Y56_RS09440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D7Y56_RS09440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D7Y56_RS09445	COG1595	DNA-templated transcription, initiation
D7Y56_RS09455	COG2814	Major facilitator Superfamily
D7Y56_RS09470	COG1309	transcriptional regulator
D7Y56_RS09475	COG0477	Major facilitator Superfamily
D7Y56_RS09480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D7Y56_RS09500	COG1994	Peptidase M50
D7Y56_RS09560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D7Y56_RS09565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS09570	COG1120	ATPase activity
D7Y56_RS09580	COG2837	iron assimilation
D7Y56_RS09585	COG0672	)-iron permease
D7Y56_RS09605	COG1834	amidinotransferase
D7Y56_RS09620	COG2814	Major facilitator Superfamily
D7Y56_RS09630	COG3540	Alkaline phosphatase
D7Y56_RS09655	COG0667	Aldo Keto reductase
D7Y56_RS09660	COG1309	transcriptional regulator
D7Y56_RS09690	COG2124	cytochrome p450
D7Y56_RS09735	COG3022	response to hydroperoxide
D7Y56_RS09740	COG0800	Aldolase
D7Y56_RS09755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D7Y56_RS09760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D7Y56_RS09810	COG0438	transferase activity, transferring glycosyl groups
D7Y56_RS09815	COG1309	transcriptional regulator
D7Y56_RS09835	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7Y56_RS09855	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS09870	COG1657	PFAM Prenyltransferase squalene oxidase
D7Y56_RS09885	COG3845	ABC transporter
D7Y56_RS09995	COG0494	nUDIX hydrolase
D7Y56_RS10055	COG1358	cellular component organization or biogenesis
D7Y56_RS10105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D7Y56_RS10115	COG0477	Major facilitator Superfamily
D7Y56_RS10120	COG1309	transcriptional regulator
D7Y56_RS10135	COG4585	Histidine kinase
D7Y56_RS10140	COG2197	response regulator
D7Y56_RS10155	COG0667	Aldo Keto reductase
D7Y56_RS10160	COG0789	Transcriptional regulator
D7Y56_RS10205	COG1733	regulation of RNA biosynthetic process
D7Y56_RS10210	COG1741	Belongs to the pirin family
D7Y56_RS10225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D7Y56_RS10230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7Y56_RS10235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7Y56_RS10275	COG4213	ABC transporter substrate-binding protein
D7Y56_RS10285	COG4214	carbohydrate transport
D7Y56_RS10300	COG1764	response to oxidative stress
D7Y56_RS10310	COG2130	NADP-dependent
D7Y56_RS10340	COG1522	sequence-specific DNA binding
D7Y56_RS10350	COG0318	PFAM AMP-dependent synthetase and ligase
D7Y56_RS10355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D7Y56_RS10355	COG0825	malonyl-CoA metabolic process
D7Y56_RS10365	COG3629	intracellular signal transduction
D7Y56_RS10365	COG3903	Transcriptional regulator
D7Y56_RS10375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7Y56_RS10415	COG1404	Belongs to the peptidase S8 family
D7Y56_RS10505	COG1070	Carbohydrate kinase
D7Y56_RS10520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7Y56_RS10525	COG0358	DNA primase activity
D7Y56_RS10535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D7Y56_RS10545	COG2949	membrane
D7Y56_RS10550	COG0243	molybdopterin cofactor binding
D7Y56_RS10565	COG0431	NADPH-dependent FMN reductase
D7Y56_RS10595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7Y56_RS10600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7Y56_RS10600	COG2146	nitrite reductase [NAD(P)H] activity
D7Y56_RS10605	COG2146	nitrite reductase [NAD(P)H] activity
D7Y56_RS10605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7Y56_RS10625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D7Y56_RS10625	COG0574	Belongs to the PEP-utilizing enzyme family
D7Y56_RS10640	COG0477	Major facilitator Superfamily
D7Y56_RS10655	COG0423	glycine-tRNA ligase activity
D7Y56_RS10665	COG1121	(ABC) transporter
D7Y56_RS10670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7Y56_RS10680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D7Y56_RS10685	COG1381	Involved in DNA repair and RecF pathway recombination
D7Y56_RS10695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D7Y56_RS10710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D7Y56_RS10720	COG2315	Protein conserved in bacteria
D7Y56_RS10730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D7Y56_RS10740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7Y56_RS10750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D7Y56_RS10755	COG1234	tRNA 3'-trailer cleavage
D7Y56_RS10775	COG0484	heat shock protein binding
D7Y56_RS10780	COG1420	regulation of RNA biosynthetic process
D7Y56_RS10815	COG0481	GTPase activity
D7Y56_RS10820	COG0268	Binds directly to 16S ribosomal RNA
D7Y56_RS10840	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D7Y56_RS10855	COG1555	photosystem II stabilization
D7Y56_RS10860	COG1307	EDD domain protein, DegV family
D7Y56_RS10870	COG0495	leucyl-tRNA aminoacylation
D7Y56_RS10880	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D7Y56_RS10900	COG0588	phosphoglycerate mutase activity
D7Y56_RS10905	COG0799	negative regulation of ribosome biogenesis
D7Y56_RS10915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D7Y56_RS10920	COG0501	Belongs to the peptidase M48B family
D7Y56_RS10935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D7Y56_RS10945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D7Y56_RS10970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D7Y56_RS10975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D7Y56_RS10980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D7Y56_RS11020	COG0673	inositol 2-dehydrogenase activity
D7Y56_RS11025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D7Y56_RS11030	COG1530	ribonuclease E activity
D7Y56_RS11055	COG0772	Belongs to the SEDS family
D7Y56_RS11075	COG1077	Cell shape determining protein MreB Mrl
D7Y56_RS11080	COG0105	UTP biosynthetic process
D7Y56_RS11090	COG0285	dihydrofolate synthase activity
D7Y56_RS11095	COG0525	valine-tRNA ligase activity
D7Y56_RS11105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D7Y56_RS11110	COG0740	serine-type endopeptidase activity
D7Y56_RS11115	COG0740	serine-type endopeptidase activity
D7Y56_RS11120	COG0544	peptidyl-prolyl cis-trans isomerase activity
D7Y56_RS11145	COG3594	Acyltransferase
D7Y56_RS11155	COG0475	glutathione-regulated potassium exporter activity
D7Y56_RS11165	COG4552	Acetyltransferase involved in intracellular survival and related
D7Y56_RS11200	COG1113	amino acid transport
D7Y56_RS11215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D7Y56_RS11225	COG2211	Major facilitator Superfamily
D7Y56_RS11235	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D7Y56_RS11270	COG4266	Belongs to the allantoicase family
D7Y56_RS11295	COG3291	Pkd domain containing protein
D7Y56_RS11295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D7Y56_RS11305	COG0668	transmembrane transport
D7Y56_RS11310	COG1940	carbohydrate kinase activity
D7Y56_RS11310	COG1846	Transcriptional regulator
D7Y56_RS11315	COG1653	transport
D7Y56_RS11320	COG1175	transmembrane transport
D7Y56_RS11325	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS11330	COG1486	melibiose metabolic process
D7Y56_RS11375	COG2346	COG2346, Truncated hemoglobins
D7Y56_RS11390	COG1136	(ABC) transporter
D7Y56_RS11390	COG0577	efflux transmembrane transporter activity
D7Y56_RS11415	COG0629	single-stranded DNA binding
D7Y56_RS11435	COG0647	UMP catabolic process
D7Y56_RS11450	COG1129	ABC transporter
D7Y56_RS11460	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7Y56_RS11465	COG1879	ABC-type sugar transport system periplasmic component
D7Y56_RS11470	COG3254	rhamnose metabolic process
D7Y56_RS11505	COG3962	Belongs to the TPP enzyme family
D7Y56_RS11510	COG3718	enzyme involved in inositol metabolism
D7Y56_RS11520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7Y56_RS11535	COG2409	Drug exporters of the RND superfamily
D7Y56_RS11560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7Y56_RS11570	COG0500	methyltransferase
D7Y56_RS11590	COG1082	Xylose isomerase domain protein TIM barrel
D7Y56_RS11590	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D7Y56_RS11600	COG0673	inositol 2-dehydrogenase activity
D7Y56_RS11605	COG1609	Transcriptional regulator
D7Y56_RS11630	COG0515	serine threonine protein kinase
D7Y56_RS11660	COG1404	Belongs to the peptidase S8 family
D7Y56_RS11685	COG1472	Belongs to the glycosyl hydrolase 3 family
D7Y56_RS11720	COG0028	Belongs to the TPP enzyme family
D7Y56_RS11730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7Y56_RS11780	COG1175	transmembrane transport
D7Y56_RS11785	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS11790	COG1609	Transcriptional regulator
D7Y56_RS11795	COG1874	Beta-galactosidase
D7Y56_RS11820	COG1946	Acyl-CoA thioesterase
D7Y56_RS11845	COG1309	transcriptional regulator
D7Y56_RS11850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7Y56_RS11865	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS11885	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D7Y56_RS11905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7Y56_RS11910	COG0589	response to stress
D7Y56_RS11915	COG4977	sequence-specific DNA binding
D7Y56_RS11950	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS11975	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS11985	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D7Y56_RS12050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7Y56_RS12070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7Y56_RS12075	COG0765	amino acid transport
D7Y56_RS12080	COG0765	amino acid transport
D7Y56_RS12085	COG1126	abc transporter atp-binding protein
D7Y56_RS12100	COG3397	chitin binding
D7Y56_RS12145	COG0673	inositol 2-dehydrogenase activity
D7Y56_RS12150	COG4702	Belongs to the UPF0303 family
D7Y56_RS12155	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7Y56_RS12160	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
D7Y56_RS12160	COG0706	membrane insertase activity
D7Y56_RS12200	COG0477	Major facilitator Superfamily
D7Y56_RS12265	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D7Y56_RS12285	COG2197	response regulator
D7Y56_RS12290	COG4585	Histidine kinase
D7Y56_RS12295	COG2409	Drug exporters of the RND superfamily
D7Y56_RS12300	COG3708	Transcriptional regulator
D7Y56_RS12300	COG2207	Transcriptional regulator
D7Y56_RS12340	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D7Y56_RS12350	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS12355	COG1396	sequence-specific DNA binding
D7Y56_RS12375	COG1349	DNA-binding transcription factor activity
D7Y56_RS12385	COG0137	argininosuccinate synthase activity
D7Y56_RS12395	COG2733	membrane
D7Y56_RS12425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7Y56_RS12450	COG0477	Major facilitator Superfamily
D7Y56_RS12470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D7Y56_RS12480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D7Y56_RS12485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7Y56_RS12490	COG1263	PTS System
D7Y56_RS12495	COG1263	PTS System
D7Y56_RS12500	COG1234	tRNA 3'-trailer cleavage
D7Y56_RS12530	COG1113	amino acid transport
D7Y56_RS12540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D7Y56_RS12550	COG1335	isochorismatase
D7Y56_RS12585	COG0277	FAD linked oxidase domain protein
D7Y56_RS12595	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D7Y56_RS12605	COG1174	glycine betaine transport
D7Y56_RS12615	COG1174	glycine betaine transport
D7Y56_RS12690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D7Y56_RS12695	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS12700	COG1175	transmembrane transport
D7Y56_RS12715	COG1678	Uncharacterized ACR, COG1678
D7Y56_RS12720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D7Y56_RS12725	COG0776	regulation of translation
D7Y56_RS12735	COG3973	AAA domain
D7Y56_RS12735	COG3973	AAA domain
D7Y56_RS12765	COG2223	nitrite transmembrane transporter activity
D7Y56_RS12785	COG0583	DNA-binding transcription factor activity
D7Y56_RS12800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D7Y56_RS12805	COG0793	Belongs to the peptidase S41A family
D7Y56_RS12810	COG2177	Part of the ABC transporter FtsEX involved in
D7Y56_RS12815	COG2884	Cell division ATP-binding protein ftsE
D7Y56_RS12830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D7Y56_RS12835	COG0515	serine threonine protein kinase
D7Y56_RS12840	COG0515	serine threonine protein kinase
D7Y56_RS12850	COG1653	transport
D7Y56_RS12855	COG1175	transmembrane transport
D7Y56_RS12860	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS12865	COG0463	Glycosyl transferase, family 2
D7Y56_RS12865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D7Y56_RS12870	COG0438	transferase activity, transferring glycosyl groups
D7Y56_RS12875	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D7Y56_RS12880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D7Y56_RS12890	COG2226	methyltransferase
D7Y56_RS12890	COG1073	alpha beta
D7Y56_RS12895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D7Y56_RS12900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D7Y56_RS12905	COG1309	transcriptional regulator
D7Y56_RS12915	COG1134	teichoic acid transport
D7Y56_RS12920	COG2902	Dehydrogenase
D7Y56_RS12940	COG0653	protein targeting
D7Y56_RS12955	COG2197	response regulator
D7Y56_RS12960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D7Y56_RS12975	COG0823	Involved in the tonB-independent uptake of proteins
D7Y56_RS12980	COG5002	protein histidine kinase activity
D7Y56_RS12980	COG5000	phosphorelay sensor kinase activity
D7Y56_RS12985	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS12990	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D7Y56_RS13010	COG0714	Associated with various cellular activities
D7Y56_RS13055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D7Y56_RS13065	COG1482	cell wall glycoprotein biosynthetic process
D7Y56_RS13075	COG2835	tetraacyldisaccharide 4'-kinase activity
D7Y56_RS13085	COG1620	l-lactate permease
D7Y56_RS13125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D7Y56_RS13130	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D7Y56_RS13130	COG0778	Nitroreductase
D7Y56_RS13155	COG1316	TRANSCRIPTIONal
D7Y56_RS13160	COG1316	TRANSCRIPTIONal
D7Y56_RS13175	COG1316	TRANSCRIPTIONal
D7Y56_RS13180	COG0477	Major facilitator Superfamily
D7Y56_RS13185	COG1473	amidohydrolase
D7Y56_RS13195	COG1607	acyl-coa hydrolase
D7Y56_RS13200	COG1316	TRANSCRIPTIONal
D7Y56_RS13230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D7Y56_RS13255	COG2205	protein histidine kinase activity
D7Y56_RS13260	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS13265	COG3104	oligopeptide transport
D7Y56_RS13275	COG1366	Belongs to the anti-sigma-factor antagonist family
D7Y56_RS13280	COG1191	sigma factor activity
D7Y56_RS13290	COG1228	amidohydrolase
D7Y56_RS13300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7Y56_RS13305	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D7Y56_RS13360	COG2755	lipolytic protein G-D-S-L family
D7Y56_RS13365	COG0183	Belongs to the thiolase family
D7Y56_RS13410	COG4608	Belongs to the ABC transporter superfamily
D7Y56_RS13415	COG0444	Belongs to the ABC transporter superfamily
D7Y56_RS13425	COG0601	transmembrane transport
D7Y56_RS13435	COG1609	Transcriptional regulator
D7Y56_RS13440	COG1136	(ABC) transporter
D7Y56_RS13445	COG1136	(ABC) transporter
D7Y56_RS13445	COG0577	efflux transmembrane transporter activity
D7Y56_RS13450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D7Y56_RS13455	COG1252	NADH dehydrogenase
D7Y56_RS13475	COG0148	phosphopyruvate hydratase activity
D7Y56_RS13490	COG2124	cytochrome p450
D7Y56_RS13505	COG2815	serine threonine protein kinase
D7Y56_RS13505	COG0515	serine threonine protein kinase
D7Y56_RS13545	COG0577	efflux transmembrane transporter activity
D7Y56_RS13550	COG1136	(ABC) transporter
D7Y56_RS13550	COG0577	efflux transmembrane transporter activity
D7Y56_RS13555	COG0477	Major facilitator Superfamily
D7Y56_RS13560	COG0596	Alpha beta hydrolase
D7Y56_RS13570	COG1366	Belongs to the anti-sigma-factor antagonist family
D7Y56_RS13600	COG4585	Histidine kinase
D7Y56_RS13615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D7Y56_RS13620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D7Y56_RS13625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D7Y56_RS13630	COG0193	aminoacyl-tRNA hydrolase activity
D7Y56_RS13650	COG1309	transcriptional regulator
D7Y56_RS13660	COG4106	trans-aconitate 2-methyltransferase activity
D7Y56_RS13665	COG1846	Transcriptional regulator
D7Y56_RS13670	COG2197	response regulator
D7Y56_RS13680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D7Y56_RS13695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7Y56_RS13725	COG0488	(ABC) transporter
D7Y56_RS13740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D7Y56_RS13745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D7Y56_RS13755	COG0084	hydrolase, TatD family'
D7Y56_RS13780	COG0442	prolyl-tRNA aminoacylation
D7Y56_RS13800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7Y56_RS13800	COG0456	acetyltransferase
D7Y56_RS13810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D7Y56_RS13815	COG1122	ATPase activity
D7Y56_RS13825	COG0310	cobalt ion transport
D7Y56_RS13835	COG2409	Drug exporters of the RND superfamily
D7Y56_RS13855	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS13865	COG2072	flavoprotein involved in K transport
D7Y56_RS13930	COG0521	Mo-molybdopterin cofactor biosynthetic process
D7Y56_RS13935	COG0315	cyclic pyranopterin monophosphate synthase activity
D7Y56_RS13945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D7Y56_RS13950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D7Y56_RS13960	COG3263	regulation of cellular component size
D7Y56_RS13975	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D7Y56_RS13985	COG1970	mechanosensitive ion channel activity
D7Y56_RS14005	COG0437	4 iron, 4 sulfur cluster binding
D7Y56_RS14010	COG0243	molybdopterin cofactor binding
D7Y56_RS14035	COG1247	-acetyltransferase
D7Y56_RS14040	COG3384	dioxygenase
D7Y56_RS14045	COG1846	Transcriptional regulator
D7Y56_RS14075	COG0582	viral genome integration into host DNA
D7Y56_RS14120	COG2188	Transcriptional regulator
D7Y56_RS14125	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D7Y56_RS14160	COG2378	regulation of single-species biofilm formation
D7Y56_RS14225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7Y56_RS14230	COG1902	pentaerythritol trinitrate reductase activity
D7Y56_RS14235	COG0789	Transcriptional regulator
D7Y56_RS14240	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D7Y56_RS14250	COG2186	Transcriptional regulator
D7Y56_RS14260	COG2376	Dihydroxyacetone kinase
D7Y56_RS14265	COG0698	ribose 5-phosphate isomerase
D7Y56_RS14270	COG0149	triose-phosphate isomerase activity
D7Y56_RS14275	COG1082	Xylose isomerase domain protein TIM barrel
D7Y56_RS14280	COG2084	Dehydrogenase
D7Y56_RS14290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7Y56_RS14305	COG0768	penicillin binding
D7Y56_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS14335	COG1309	transcriptional regulator
D7Y56_RS14345	COG1301	dicarboxylic acid transport
D7Y56_RS14360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D7Y56_RS14370	COG0163	prenyltransferase activity
D7Y56_RS14380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D7Y56_RS14385	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D7Y56_RS14405	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS14410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7Y56_RS14415	COG1333	cytochrome c biogenesis protein
D7Y56_RS14420	COG0785	Cytochrome C biogenesis protein
D7Y56_RS14425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7Y56_RS14435	COG0406	alpha-ribazole phosphatase activity
D7Y56_RS14440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D7Y56_RS14475	COG2770	Histidine kinase
D7Y56_RS14475	COG2208	phosphoserine phosphatase activity
D7Y56_RS14480	COG0659	secondary active sulfate transmembrane transporter activity
D7Y56_RS14515	COG1742	UPF0060 membrane protein
D7Y56_RS14530	COG1690	Belongs to the RtcB family
D7Y56_RS14550	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D7Y56_RS14555	COG0018	arginyl-trna synthetase
D7Y56_RS14565	COG1595	DNA-templated transcription, initiation
D7Y56_RS14605	COG4585	Histidine kinase
D7Y56_RS14610	COG2197	response regulator
D7Y56_RS14635	COG0113	porphobilinogen synthase activity
D7Y56_RS14645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D7Y56_RS14645	COG1648	precorrin-2 dehydrogenase activity
D7Y56_RS14650	COG0181	hydroxymethylbilane synthase activity
D7Y56_RS14655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D7Y56_RS14660	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D7Y56_RS14710	COG0123	including yeast histone deacetylase and acetoin utilization protein
D7Y56_RS14715	COG2223	nitrite transmembrane transporter activity
D7Y56_RS14720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D7Y56_RS14755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D7Y56_RS14765	COG0842	Transport permease protein
D7Y56_RS14765	COG1129	ABC transporter
D7Y56_RS14785	COG0515	serine threonine protein kinase
D7Y56_RS14785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D7Y56_RS14790	COG0129	dihydroxy-acid dehydratase activity
D7Y56_RS14805	COG1082	Xylose isomerase domain protein TIM barrel
D7Y56_RS14810	COG0248	Ppx GppA phosphatase
D7Y56_RS14830	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D7Y56_RS14835	COG0667	Aldo Keto reductase
D7Y56_RS14890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS14900	COG1194	a g-specific adenine glycosylase
D7Y56_RS14905	COG1595	DNA-templated transcription, initiation
D7Y56_RS14915	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS14920	COG2205	protein histidine kinase activity
D7Y56_RS14925	COG0477	Major facilitator Superfamily
D7Y56_RS14935	COG0739	heme binding
D7Y56_RS14960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D7Y56_RS14980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D7Y56_RS14990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D7Y56_RS14995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D7Y56_RS15010	COG2197	response regulator
D7Y56_RS15040	COG1174	glycine betaine transport
D7Y56_RS15045	COG1174	glycine betaine transport
D7Y56_RS15050	COG0517	IMP dehydrogenase activity
D7Y56_RS15050	COG1125	glycine betaine transport
D7Y56_RS15065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D7Y56_RS15085	COG0302	gtp cyclohydrolase
D7Y56_RS15100	COG0037	tRNA processing
D7Y56_RS15110	COG2027	D-alanyl-D-alanine carboxypeptidase
D7Y56_RS15115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D7Y56_RS15130	COG0393	Putative heavy-metal-binding
D7Y56_RS15135	COG0655	NAD(P)H dehydrogenase (quinone) activity
D7Y56_RS15140	COG0076	glutamate decarboxylase activity
D7Y56_RS15160	COG2318	DinB family
D7Y56_RS15165	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS15200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7Y56_RS15200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7Y56_RS15220	COG2897	thiosulfate sulfurtransferase activity
D7Y56_RS15230	COG1335	isochorismatase
D7Y56_RS15245	COG2188	Transcriptional regulator
D7Y56_RS15315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D7Y56_RS15320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D7Y56_RS15325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D7Y56_RS15325	COG1754	DNA topoisomerase type I activity
D7Y56_RS15335	COG2890	protein-(glutamine-N5) methyltransferase activity
D7Y56_RS15345	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D7Y56_RS15355	COG1366	Belongs to the anti-sigma-factor antagonist family
D7Y56_RS15360	COG1111	helicase
D7Y56_RS15360	COG1205	dead DEAH box helicase
D7Y56_RS15420	COG0288	reversible hydration of carbon dioxide
D7Y56_RS15425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7Y56_RS15430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D7Y56_RS15440	COG2267	carboxylic ester hydrolase activity
D7Y56_RS15470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7Y56_RS15495	COG0003	Pfam Anion-transporting ATPase
D7Y56_RS15510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D7Y56_RS15515	COG1610	YqeY-like protein
D7Y56_RS15520	COG1408	metallophosphoesterase
D7Y56_RS15530	COG2828	Protein conserved in bacteria
D7Y56_RS15545	COG1309	transcriptional regulator
D7Y56_RS15555	COG0326	Molecular chaperone. Has ATPase activity
D7Y56_RS15560	COG2755	lipolytic protein G-D-S-L family
D7Y56_RS15595	COG1595	DNA-templated transcription, initiation
D7Y56_RS15615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D7Y56_RS15620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D7Y56_RS15635	COG1802	Transcriptional regulator
D7Y56_RS15645	COG0693	protein deglycase activity
D7Y56_RS15660	COG0592	DNA-directed DNA polymerase activity
D7Y56_RS15685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D7Y56_RS15700	COG1131	(ABC) transporter
D7Y56_RS15705	COG3559	Exporter of polyketide antibiotics
D7Y56_RS15715	COG2124	cytochrome p450
D7Y56_RS15720	COG2197	response regulator
D7Y56_RS15725	COG4585	Histidine kinase
D7Y56_RS15740	COG3483	tryptophan 2,3-dioxygenase activity
D7Y56_RS15755	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D7Y56_RS15760	COG0191	fructose-bisphosphate aldolase activity
D7Y56_RS15765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D7Y56_RS15780	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D7Y56_RS15810	COG0542	response to heat
D7Y56_RS15840	COG0789	Transcriptional regulator
D7Y56_RS15845	COG0484	heat shock protein binding
D7Y56_RS15850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D7Y56_RS15855	COG0443	Heat shock 70 kDa protein
D7Y56_RS15860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D7Y56_RS15865	COG2181	nitrate reductase activity
D7Y56_RS15865	COG0247	lactate metabolic process
D7Y56_RS15875	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D7Y56_RS15880	COG0717	Belongs to the dCTP deaminase family
D7Y56_RS15985	COG3209	COG3209 Rhs family protein
D7Y56_RS16020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D7Y56_RS16050	COG0488	(ABC) transporter
D7Y56_RS16065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D7Y56_RS16090	COG1309	transcriptional regulator
D7Y56_RS16110	COG3594	Acyltransferase
D7Y56_RS16120	COG0513	Belongs to the DEAD box helicase family
D7Y56_RS16125	COG1278	Cold shock
D7Y56_RS16165	COG1585	Membrane protein implicated in regulation of membrane protease activity
D7Y56_RS16170	COG2268	Band 7 protein
D7Y56_RS16185	COG0490	domain, Protein
D7Y56_RS16190	COG0475	glutathione-regulated potassium exporter activity
D7Y56_RS16225	COG2255	four-way junction helicase activity
D7Y56_RS16235	COG0180	Tryptophanyl-tRNA synthetase
D7Y56_RS16240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7Y56_RS16265	COG0604	alcohol dehydrogenase
D7Y56_RS16290	COG2205	protein histidine kinase activity
D7Y56_RS16295	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS16300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7Y56_RS16315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D7Y56_RS16325	COG0628	permease
D7Y56_RS16330	COG1741	Belongs to the pirin family
D7Y56_RS16340	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS16345	COG1362	aminopeptidase activity
D7Y56_RS16355	COG3629	intracellular signal transduction
D7Y56_RS16355	COG3903	Transcriptional regulator
D7Y56_RS16375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D7Y56_RS16400	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7Y56_RS16405	COG0022	dehydrogenase e1 component
D7Y56_RS16430	COG0515	serine threonine protein kinase
D7Y56_RS16435	COG0515	serine threonine protein kinase
D7Y56_RS16450	COG0604	alcohol dehydrogenase
D7Y56_RS16450	COG3321	synthase
D7Y56_RS16450	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS16455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D7Y56_RS16460	COG0303	'Molybdopterin
D7Y56_RS16490	COG1522	sequence-specific DNA binding
D7Y56_RS16495	COG1309	transcriptional regulator
D7Y56_RS16520	COG3396	Phenylacetate-CoA oxygenase
D7Y56_RS16525	COG3460	Phenylacetate-CoA oxygenase
D7Y56_RS16530	COG3396	Phenylacetate-CoA oxygenase
D7Y56_RS16535	COG2151	metal-sulfur cluster biosynthetic enzyme
D7Y56_RS16540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D7Y56_RS16545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7Y56_RS16570	COG1733	regulation of RNA biosynthetic process
D7Y56_RS16575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D7Y56_RS16585	COG1716	ATPase activity
D7Y56_RS16590	COG1716	ATPase activity
D7Y56_RS16605	COG0768	penicillin binding
D7Y56_RS16615	COG3764	Sortase (surface protein transpeptidase)
D7Y56_RS16620	COG3764	Sortase (surface protein transpeptidase)
D7Y56_RS16645	COG0705	Rhomboid family
D7Y56_RS16670	COG0515	serine threonine protein kinase
D7Y56_RS16700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7Y56_RS16710	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D7Y56_RS16715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D7Y56_RS16720	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D7Y56_RS16725	COG0592	DNA-directed DNA polymerase activity
D7Y56_RS16740	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D7Y56_RS16745	COG0594	ribonuclease P activity
D7Y56_RS16750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D7Y56_RS16755	COG0706	membrane insertase activity
D7Y56_RS16765	COG0357	Ribosomal RNA small subunit methyltransferase G
D7Y56_RS16770	COG1192	Involved in chromosome partitioning
D7Y56_RS16785	COG3118	belongs to the thioredoxin family
D7Y56_RS16790	COG0492	ferredoxin-NADP+ reductase activity
D7Y56_RS16800	COG1595	DNA-templated transcription, initiation
D7Y56_RS16805	COG2815	serine threonine protein kinase
D7Y56_RS16805	COG0515	serine threonine protein kinase
D7Y56_RS16820	COG0617	tRNA 3'-terminal CCA addition
D7Y56_RS16840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7Y56_RS16865	COG0360	Binds together with S18 to 16S ribosomal RNA
D7Y56_RS16870	COG0629	single-stranded DNA binding
D7Y56_RS16875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D7Y56_RS16880	COG0359	binds to the 23S rRNA
D7Y56_RS16895	COG0305	Participates in initiation and elongation during chromosome replication
D7Y56_RS16920	COG2814	Major facilitator Superfamily
D7Y56_RS16935	COG0626	cystathionine gamma-synthase activity
D7Y56_RS16940	COG1950	PFAM Membrane protein of
D7Y56_RS16945	COG0662	Cupin 2, conserved barrel domain protein
D7Y56_RS16970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D7Y56_RS16980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D7Y56_RS16985	COG1609	Transcriptional regulator
D7Y56_RS16990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D7Y56_RS16995	COG1271	oxidase subunit
D7Y56_RS17000	COG1294	oxidase, subunit
D7Y56_RS17005	COG4988	ABC transporter
D7Y56_RS17015	COG0561	phosphatase activity
D7Y56_RS17030	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D7Y56_RS17040	COG1131	(ABC) transporter
D7Y56_RS17070	COG0561	phosphatase activity
D7Y56_RS17075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D7Y56_RS17085	COG2837	iron assimilation
D7Y56_RS17090	COG2372	response to copper ion
D7Y56_RS17100	COG1999	signal sequence binding
D7Y56_RS17120	COG0006	proline dipeptidase activity
D7Y56_RS17135	COG0653	protein targeting
D7Y56_RS17155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7Y56_RS17225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7Y56_RS17230	COG1215	transferase activity, transferring glycosyl groups
D7Y56_RS17265	COG1595	DNA-templated transcription, initiation
D7Y56_RS17270	COG0318	PFAM AMP-dependent synthetase and ligase
D7Y56_RS17295	COG1252	NADH dehydrogenase
D7Y56_RS17325	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS17330	COG2205	protein histidine kinase activity
D7Y56_RS17335	COG1215	transferase activity, transferring glycosyl groups
D7Y56_RS17340	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D7Y56_RS17345	COG0477	Major facilitator Superfamily
D7Y56_RS17360	COG3467	pyridoxamine 5'-phosphate
D7Y56_RS17365	COG2353	YceI-like domain
D7Y56_RS17370	COG0477	Major facilitator Superfamily
D7Y56_RS17385	COG1191	sigma factor activity
D7Y56_RS17390	COG1191	sigma factor activity
D7Y56_RS17400	COG0477	Major facilitator Superfamily
D7Y56_RS17430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D7Y56_RS17445	COG2234	aminopeptidase activity
D7Y56_RS17455	COG3795	YCII-related domain
D7Y56_RS17470	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D7Y56_RS17495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7Y56_RS17595	COG1674	ftsk spoiiie
D7Y56_RS17650	COG0151	Belongs to the GarS family
D7Y56_RS17665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D7Y56_RS17695	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D7Y56_RS17700	COG0047	phosphoribosylformylglycinamidine synthase activity
D7Y56_RS17705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D7Y56_RS17740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D7Y56_RS17750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D7Y56_RS17775	COG1643	Atp-dependent helicase
D7Y56_RS17780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D7Y56_RS17780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D7Y56_RS17815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7Y56_RS17820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7Y56_RS17830	COG0513	Belongs to the DEAD box helicase family
D7Y56_RS17875	COG1653	transport
D7Y56_RS17905	COG0739	heme binding
D7Y56_RS17905	COG0741	lytic transglycosylase activity
D7Y56_RS17905	COG1196	nuclear chromosome segregation
D7Y56_RS17920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D7Y56_RS17925	COG0579	oxidoreductase
D7Y56_RS17950	COG1252	NADH dehydrogenase
D7Y56_RS17965	COG1846	Transcriptional regulator
D7Y56_RS18045	COG0667	Aldo Keto reductase
D7Y56_RS18110	COG0741	lytic transglycosylase activity
D7Y56_RS18110	COG1196	nuclear chromosome segregation
D7Y56_RS18110	COG0739	heme binding
D7Y56_RS18115	COG0671	phosphoesterase, PA-phosphatase related
D7Y56_RS18140	COG1937	Protein conserved in bacteria
D7Y56_RS18150	COG0306	phosphate transporter
D7Y56_RS18155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D7Y56_RS18175	COG0406	alpha-ribazole phosphatase activity
D7Y56_RS18175	COG0494	nUDIX hydrolase
D7Y56_RS18195	COG1116	anion transmembrane transporter activity
D7Y56_RS18200	COG1725	Transcriptional regulator
D7Y56_RS18205	COG0456	acetyltransferase
D7Y56_RS18215	COG0737	Belongs to the 5'-nucleotidase family
D7Y56_RS18220	COG0823	Involved in the tonB-independent uptake of proteins
D7Y56_RS18240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7Y56_RS18245	COG1609	Transcriptional regulator
D7Y56_RS18250	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS18275	COG2897	thiosulfate sulfurtransferase activity
D7Y56_RS18315	COG3485	protocatechuate 3,4-dioxygenase
D7Y56_RS18330	COG1490	D-aminoacyl-tRNA deacylase activity
D7Y56_RS18345	COG4552	Acetyltransferase involved in intracellular survival and related
D7Y56_RS18350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7Y56_RS18385	COG3467	pyridoxamine 5'-phosphate
D7Y56_RS18395	COG2318	DinB family
D7Y56_RS18430	COG0438	transferase activity, transferring glycosyl groups
D7Y56_RS18450	COG0697	spore germination
D7Y56_RS18455	COG1846	Transcriptional regulator
D7Y56_RS18480	COG0588	phosphoglycerate mutase activity
D7Y56_RS18495	COG5002	protein histidine kinase activity
D7Y56_RS18515	COG1329	Transcriptional regulator
D7Y56_RS18520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D7Y56_RS18525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D7Y56_RS18550	COG0215	cysteine-tRNA ligase activity
D7Y56_RS18555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7Y56_RS18565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D7Y56_RS18575	COG3842	ATPase activity
D7Y56_RS18605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7Y56_RS18620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D7Y56_RS18635	COG2197	response regulator
D7Y56_RS18640	COG4585	Histidine kinase
D7Y56_RS18660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D7Y56_RS18670	COG3300	MHYT domain
D7Y56_RS18670	COG5001	Diguanylate cyclase
D7Y56_RS18680	COG1105	Belongs to the carbohydrate kinase PfkB family
D7Y56_RS18705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D7Y56_RS18705	COG1877	trehalose-phosphatase activity
D7Y56_RS18710	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D7Y56_RS18715	COG0463	Glycosyl transferase, family 2
D7Y56_RS18740	COG2318	DinB family
D7Y56_RS18755	COG3321	synthase
D7Y56_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS18755	COG0604	alcohol dehydrogenase
D7Y56_RS18820	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D7Y56_RS18825	COG1737	Transcriptional regulator
D7Y56_RS18870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D7Y56_RS18875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D7Y56_RS18880	COG1984	allophanate hydrolase subunit 2
D7Y56_RS18895	COG2409	Drug exporters of the RND superfamily
D7Y56_RS18900	COG0531	amino acid
D7Y56_RS18905	COG3973	AAA domain
D7Y56_RS18915	COG1061	Type III restriction enzyme res subunit
D7Y56_RS18935	COG0110	maltose O-acetyltransferase activity
D7Y56_RS18940	COG3226	Transcriptional regulator
D7Y56_RS18945	COG1120	ATPase activity
D7Y56_RS18950	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS18955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS18975	COG1278	Cold shock
D7Y56_RS18980	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D7Y56_RS18985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D7Y56_RS18995	COG2814	Major facilitator Superfamily
D7Y56_RS19025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7Y56_RS19035	COG2252	PERMEase
D7Y56_RS19060	COG0667	Aldo Keto reductase
D7Y56_RS19065	COG2267	carboxylic ester hydrolase activity
D7Y56_RS19070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D7Y56_RS19085	COG2197	response regulator
D7Y56_RS19090	COG4585	Histidine kinase
D7Y56_RS19120	COG0667	Aldo Keto reductase
D7Y56_RS19155	COG1136	(ABC) transporter
D7Y56_RS19185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D7Y56_RS19215	COG0642	Histidine kinase
D7Y56_RS19220	COG1316	TRANSCRIPTIONal
D7Y56_RS19225	COG0247	lactate metabolic process
D7Y56_RS19225	COG0277	FAD linked oxidase domain protein
D7Y56_RS19230	COG0583	DNA-binding transcription factor activity
D7Y56_RS19235	COG5006	permease, DMT superfamily
D7Y56_RS19240	COG2318	DinB family
D7Y56_RS19245	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
D7Y56_RS19265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7Y56_RS19280	COG0318	PFAM AMP-dependent synthetase and ligase
D7Y56_RS19285	COG1024	Enoyl-CoA hydratase
D7Y56_RS19330	COG0259	pyridoxamine-phosphate oxidase activity
D7Y56_RS19350	COG4821	SIS domain
D7Y56_RS19370	COG1131	(ABC) transporter
D7Y56_RS19445	COG2072	flavoprotein involved in K transport
D7Y56_RS19455	COG0501	Belongs to the peptidase M48B family
D7Y56_RS19460	COG0259	pyridoxamine-phosphate oxidase activity
D7Y56_RS19465	COG1309	transcriptional regulator
D7Y56_RS19475	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D7Y56_RS19475	COG0515	serine threonine protein kinase
D7Y56_RS19505	COG1278	Cold shock
D7Y56_RS19510	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D7Y56_RS19520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D7Y56_RS19535	COG2226	methyltransferase
D7Y56_RS19555	COG0791	NLP P60 protein
D7Y56_RS19555	COG1388	LysM domain
D7Y56_RS19555	COG3103	Sh3 type 3 domain protein
D7Y56_RS19565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7Y56_RS19570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7Y56_RS19575	COG0649	NAD binding
D7Y56_RS19585	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D7Y56_RS19590	COG1034	ATP synthesis coupled electron transport
D7Y56_RS19595	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D7Y56_RS19600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7Y56_RS19605	COG0839	Belongs to the complex I subunit 6 family
D7Y56_RS19610	COG0713	ATP synthesis coupled electron transport
D7Y56_RS19615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D7Y56_RS19625	COG1007	ATP synthesis coupled electron transport
D7Y56_RS19630	COG0514	ATP-dependent DNA helicase (RecQ)
D7Y56_RS19645	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7Y56_RS19655	COG3104	oligopeptide transport
D7Y56_RS19660	COG0142	geranyltranstransferase activity
D7Y56_RS19680	COG1309	transcriptional regulator
D7Y56_RS19685	COG0561	phosphatase activity
D7Y56_RS19710	COG0702	epimerase
D7Y56_RS19715	COG1733	regulation of RNA biosynthetic process
D7Y56_RS19720	COG1013	pyruvate-flavodoxin oxidoreductase activity
D7Y56_RS19725	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D7Y56_RS19725	COG0674	pyruvate-flavodoxin oxidoreductase activity
D7Y56_RS19745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7Y56_RS19750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7Y56_RS19755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7Y56_RS19760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D7Y56_RS19765	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7Y56_RS19770	COG0839	Belongs to the complex I subunit 6 family
D7Y56_RS19775	COG0713	ATP synthesis coupled electron transport
D7Y56_RS19790	COG1007	ATP synthesis coupled electron transport
D7Y56_RS19795	COG1970	mechanosensitive ion channel activity
D7Y56_RS19800	COG0501	Belongs to the peptidase M48B family
D7Y56_RS19805	COG3304	Inner membrane component domain
D7Y56_RS19810	COG2261	transglycosylase associated protein
D7Y56_RS19815	COG1666	GTP binding
D7Y56_RS19830	COG2814	Major facilitator Superfamily
D7Y56_RS19835	COG0702	epimerase
D7Y56_RS19855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7Y56_RS19860	COG2030	dehydratase
D7Y56_RS19870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D7Y56_RS19875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D7Y56_RS19880	COG0436	Aminotransferase
D7Y56_RS19900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D7Y56_RS19905	COG0081	regulation of translation
D7Y56_RS19910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D7Y56_RS19915	COG0222	ribosome binding
D7Y56_RS19925	COG0085	RNA polymerase activity
D7Y56_RS19930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D7Y56_RS19935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D7Y56_RS19940	COG0049	tRNA binding
D7Y56_RS19945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D7Y56_RS19950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7Y56_RS19960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7Y56_RS19980	COG0051	transcription antitermination factor activity, RNA binding
D7Y56_RS19985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D7Y56_RS19990	COG0088	Forms part of the polypeptide exit tunnel
D7Y56_RS19995	COG0089	rRNA binding
D7Y56_RS20000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D7Y56_RS20005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D7Y56_RS20010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D7Y56_RS20015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D7Y56_RS20020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D7Y56_RS20025	COG0255	Belongs to the universal ribosomal protein uL29 family
D7Y56_RS20030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D7Y56_RS20035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D7Y56_RS20040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D7Y56_RS20045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D7Y56_RS20050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D7Y56_RS20060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D7Y56_RS20065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D7Y56_RS20070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D7Y56_RS20075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D7Y56_RS20080	COG1841	ribosomal large subunit assembly
D7Y56_RS20085	COG0200	Binds to the 23S rRNA
D7Y56_RS20095	COG0563	adenylate kinase activity
D7Y56_RS20105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D7Y56_RS20110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D7Y56_RS20115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D7Y56_RS20120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D7Y56_RS20125	COG0202	RNA polymerase activity
D7Y56_RS20130	COG0203	ribosomal protein L17
D7Y56_RS20135	COG0101	tRNA pseudouridine synthase activity
D7Y56_RS20150	COG0488	(ABC) transporter
D7Y56_RS20155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D7Y56_RS20160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D7Y56_RS20165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7Y56_RS20180	COG1072	(Pantothenic acid kinase))
D7Y56_RS20190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7Y56_RS20195	COG0736	holo-[acyl-carrier-protein] synthase activity
D7Y56_RS20210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D7Y56_RS20220	COG0802	atpase or kinase
D7Y56_RS20245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D7Y56_RS20260	COG4941	Belongs to the sigma-70 factor family
D7Y56_RS20285	COG0726	polysaccharide deacetylase
D7Y56_RS20295	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D7Y56_RS20305	COG4221	oxidoreductase activity
D7Y56_RS20310	COG2258	MOSC domain
D7Y56_RS20315	COG0583	DNA-binding transcription factor activity
D7Y56_RS20330	COG1595	DNA-templated transcription, initiation
D7Y56_RS20340	COG0516	GMP reductase activity
D7Y56_RS20355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D7Y56_RS20360	COG0515	serine threonine protein kinase
D7Y56_RS20370	COG0515	serine threonine protein kinase
D7Y56_RS20395	COG0519	Catalyzes the synthesis of GMP from XMP
D7Y56_RS20395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D7Y56_RS20430	COG2197	response regulator
D7Y56_RS20470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7Y56_RS20470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7Y56_RS20485	COG0714	Associated with various cellular activities
D7Y56_RS20490	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D7Y56_RS20495	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D7Y56_RS20500	COG0045	succinate-CoA ligase (ADP-forming) activity
D7Y56_RS20530	COG0138	bifunctional purine biosynthesis protein purh
D7Y56_RS20545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D7Y56_RS20560	COG0039	L-malate dehydrogenase activity
D7Y56_RS20565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7Y56_RS20570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7Y56_RS20580	COG0754	glutathionylspermidine amidase activity
D7Y56_RS20585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D7Y56_RS20590	COG0180	Tryptophanyl-tRNA synthetase
D7Y56_RS20610	COG1295	ribonuclease BN
D7Y56_RS20635	COG1309	transcriptional regulator
D7Y56_RS20645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D7Y56_RS20660	COG2009	succinate dehydrogenase
D7Y56_RS20685	COG1595	DNA-templated transcription, initiation
D7Y56_RS20695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7Y56_RS20695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7Y56_RS20710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D7Y56_RS20720	COG1216	Glycosyl transferase, family 2
D7Y56_RS20735	COG2089	acid synthase
D7Y56_RS20745	COG0515	serine threonine protein kinase
D7Y56_RS20745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D7Y56_RS20755	COG1473	amidohydrolase
D7Y56_RS20755	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D7Y56_RS20760	COG1744	ABC transporter substrate-binding protein PnrA-like
D7Y56_RS20765	COG3845	ABC transporter
D7Y56_RS20770	COG4603	Belongs to the binding-protein-dependent transport system permease family
D7Y56_RS20775	COG1079	Belongs to the binding-protein-dependent transport system permease family
D7Y56_RS20815	COG2814	Major facilitator Superfamily
D7Y56_RS20820	COG0583	DNA-binding transcription factor activity
D7Y56_RS20830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D7Y56_RS20860	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS20865	COG1595	DNA-templated transcription, initiation
D7Y56_RS20880	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS20885	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS20905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7Y56_RS20940	COG4770	biotin carboxylase activity
D7Y56_RS20950	COG0424	maF-like protein
D7Y56_RS20960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7Y56_RS20975	COG1024	Enoyl-CoA hydratase
D7Y56_RS21000	COG1376	ErfK ybiS ycfS ynhG family protein
D7Y56_RS21010	COG1136	(ABC) transporter
D7Y56_RS21015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D7Y56_RS21030	COG1396	sequence-specific DNA binding
D7Y56_RS21035	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D7Y56_RS21040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7Y56_RS21065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D7Y56_RS21080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D7Y56_RS21090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D7Y56_RS21100	COG2197	response regulator
D7Y56_RS21125	COG2318	DinB family
D7Y56_RS21140	COG1331	Highly conserved protein containing a thioredoxin domain
D7Y56_RS21150	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D7Y56_RS21175	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D7Y56_RS21190	COG1414	Transcriptional regulator
D7Y56_RS21195	COG0251	oxidation-reduction process
D7Y56_RS21200	COG2610	gluconate transmembrane transporter activity
D7Y56_RS21230	COG2894	cell division
D7Y56_RS21260	COG2197	response regulator
D7Y56_RS21280	COG2885	chlorophyll binding
D7Y56_RS21335	COG3135	benzoate transporter
D7Y56_RS21355	COG2226	methyltransferase
D7Y56_RS21370	COG0667	Aldo Keto reductase
D7Y56_RS21375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D7Y56_RS21380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D7Y56_RS21395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7Y56_RS21400	COG0450	alkyl hydroperoxide reductase
D7Y56_RS21410	COG3409	Peptidoglycan-binding domain 1 protein
D7Y56_RS21455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7Y56_RS21470	COG0114	fumarate hydratase activity
D7Y56_RS21475	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D7Y56_RS21475	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D7Y56_RS21500	COG0778	Nitroreductase
D7Y56_RS21505	COG1722	exodeoxyribonuclease VII activity
D7Y56_RS21510	COG1570	exodeoxyribonuclease VII activity
D7Y56_RS21515	COG0531	amino acid
D7Y56_RS21520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D7Y56_RS21535	COG0012	GTP binding
D7Y56_RS21600	COG3409	Peptidoglycan-binding domain 1 protein
D7Y56_RS21650	COG1842	Phage shock protein A
D7Y56_RS21670	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS21675	COG1175	transmembrane transport
D7Y56_RS21695	COG0477	Major facilitator Superfamily
D7Y56_RS21700	COG1335	isochorismatase
D7Y56_RS21710	COG1217	gtp-binding protein TYPA
D7Y56_RS21725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7Y56_RS21730	COG0444	Belongs to the ABC transporter superfamily
D7Y56_RS21735	COG4608	Belongs to the ABC transporter superfamily
D7Y56_RS21740	COG4166	transmembrane transport
D7Y56_RS21745	COG0601	transmembrane transport
D7Y56_RS21750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7Y56_RS21760	COG4608	Belongs to the ABC transporter superfamily
D7Y56_RS21780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D7Y56_RS21835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7Y56_RS21840	COG1611	Belongs to the LOG family
D7Y56_RS21845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D7Y56_RS21855	COG0519	Catalyzes the synthesis of GMP from XMP
D7Y56_RS21860	COG1024	Enoyl-CoA hydratase
D7Y56_RS21875	COG1595	DNA-templated transcription, initiation
D7Y56_RS21885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7Y56_RS21890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7Y56_RS21925	COG0598	Magnesium transport protein CorA
D7Y56_RS21935	COG2814	Major facilitator Superfamily
D7Y56_RS21950	COG2095	MarC family integral membrane protein
D7Y56_RS21955	COG1432	Conserved Protein
D7Y56_RS21965	COG0513	Belongs to the DEAD box helicase family
D7Y56_RS22005	COG0747	negative chemotaxis
D7Y56_RS22010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7Y56_RS22015	COG0601	transmembrane transport
D7Y56_RS22075	COG0210	DNA helicase
D7Y56_RS22125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D7Y56_RS22175	COG3480	Lon protease (S16) C-terminal proteolytic domain
D7Y56_RS22185	COG1615	UPF0182 protein
D7Y56_RS22210	COG0753	catalase activity
D7Y56_RS22220	COG0483	inositol monophosphate 1-phosphatase activity
D7Y56_RS22230	COG2076	Multidrug Resistance protein
D7Y56_RS22235	COG1162	GTPase activity
D7Y56_RS22240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D7Y56_RS22250	COG2135	peptidase activity
D7Y56_RS22260	COG1595	DNA-templated transcription, initiation
D7Y56_RS22265	COG5662	AntiSigma factor
D7Y56_RS22285	COG0242	peptide deformylase activity
D7Y56_RS22330	COG2188	Transcriptional regulator
D7Y56_RS22335	COG2182	Extracellular solute-binding protein
D7Y56_RS22345	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS22350	COG1472	Belongs to the glycosyl hydrolase 3 family
D7Y56_RS22355	COG0363	glucosamine-6-phosphate deaminase activity
D7Y56_RS22370	COG1597	lipid kinase activity
D7Y56_RS22385	COG2172	sigma factor antagonist activity
D7Y56_RS22410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D7Y56_RS22410	COG1017	nitric oxide dioxygenase activity
D7Y56_RS22415	COG1959	2 iron, 2 sulfur cluster binding
D7Y56_RS22420	COG0277	FAD linked oxidase domain protein
D7Y56_RS22430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7Y56_RS22435	COG0142	geranyltranstransferase activity
D7Y56_RS22450	COG5640	endopeptidase activity
D7Y56_RS22490	COG4106	trans-aconitate 2-methyltransferase activity
D7Y56_RS22495	COG1126	abc transporter atp-binding protein
D7Y56_RS22500	COG0765	amino acid transport
D7Y56_RS22505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7Y56_RS22510	COG0281	malic enzyme
D7Y56_RS22515	COG0604	alcohol dehydrogenase
D7Y56_RS22550	COG0567	Dehydrogenase, E1 component
D7Y56_RS22550	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7Y56_RS22560	COG2205	protein histidine kinase activity
D7Y56_RS22565	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS22575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D7Y56_RS22580	COG0726	polysaccharide deacetylase
D7Y56_RS22625	COG0791	NLP P60 protein
D7Y56_RS22680	COG0768	penicillin binding
D7Y56_RS22710	COG3285	dna ligase
D7Y56_RS22710	COG1793	dna ligase
D7Y56_RS22715	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D7Y56_RS22730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7Y56_RS22755	COG0018	arginyl-trna synthetase
D7Y56_RS22760	COG0019	diaminopimelate decarboxylase activity
D7Y56_RS22765	COG0460	homoserine dehydrogenase
D7Y56_RS22770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D7Y56_RS22775	COG0083	homoserine kinase activity
D7Y56_RS22790	COG1316	TRANSCRIPTIONal
D7Y56_RS22795	COG0254	rRNA binding
D7Y56_RS22800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D7Y56_RS22805	COG2890	protein-(glutamine-N5) methyltransferase activity
D7Y56_RS22815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D7Y56_RS22820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7Y56_RS22840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D7Y56_RS22845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D7Y56_RS22850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D7Y56_RS22855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D7Y56_RS22860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D7Y56_RS22865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D7Y56_RS22870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D7Y56_RS22885	COG2197	response regulator
D7Y56_RS22890	COG4585	Histidine kinase
D7Y56_RS22905	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7Y56_RS22920	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D7Y56_RS22975	COG0183	Belongs to the thiolase family
D7Y56_RS22990	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS22995	COG5002	protein histidine kinase activity
D7Y56_RS23055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7Y56_RS23055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7Y56_RS23095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D7Y56_RS23100	COG0280	phosphate acetyltransferase
D7Y56_RS23100	COG0857	belongs to the CobB CobQ family
D7Y56_RS23105	COG0205	6-phosphofructokinase activity
D7Y56_RS23115	COG4565	transcriptional regulatory protein
D7Y56_RS23120	COG3290	protein histidine kinase activity
D7Y56_RS23125	COG1301	dicarboxylic acid transport
D7Y56_RS23145	COG3118	belongs to the thioredoxin family
D7Y56_RS23150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D7Y56_RS23160	COG0366	Alpha amylase catalytic
D7Y56_RS23165	COG0366	Alpha amylase catalytic
D7Y56_RS23170	COG0058	SHG alpha-glucan phosphorylase activity
D7Y56_RS23185	COG1132	(ABC) transporter
D7Y56_RS23190	COG1132	(ABC) transporter
D7Y56_RS23250	COG1131	(ABC) transporter
D7Y56_RS23265	COG1760	l-serine dehydratase
D7Y56_RS23270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7Y56_RS23275	COG0509	glycine decarboxylation via glycine cleavage system
D7Y56_RS23280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D7Y56_RS23305	COG0747	negative chemotaxis
D7Y56_RS23315	COG0444	Belongs to the ABC transporter superfamily
D7Y56_RS23320	COG4608	Belongs to the ABC transporter superfamily
D7Y56_RS23325	COG2860	membrane
D7Y56_RS23335	COG2378	regulation of single-species biofilm formation
D7Y56_RS23355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D7Y56_RS23355	COG0515	serine threonine protein kinase
D7Y56_RS23370	COG0482	sulfurtransferase activity
D7Y56_RS23390	COG4221	oxidoreductase activity
D7Y56_RS23410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D7Y56_RS23415	COG0154	amidase activity
D7Y56_RS23425	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D7Y56_RS23435	COG2409	Drug exporters of the RND superfamily
D7Y56_RS23455	COG2197	response regulator
D7Y56_RS23460	COG2133	pyrroloquinoline quinone binding
D7Y56_RS23465	COG0667	Aldo Keto reductase
D7Y56_RS23485	COG0440	acetolactate synthase activity
D7Y56_RS23490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D7Y56_RS23495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7Y56_RS23500	COG2508	Transcriptional regulator
D7Y56_RS23505	COG0506	proline dehydrogenase activity
D7Y56_RS23510	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS23520	COG1309	transcriptional regulator
D7Y56_RS23525	COG0473	3-isopropylmalate dehydrogenase activity
D7Y56_RS23530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D7Y56_RS23535	COG2957	Belongs to the agmatine deiminase family
D7Y56_RS23545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D7Y56_RS23555	COG1609	Transcriptional regulator
D7Y56_RS23560	COG4166	transmembrane transport
D7Y56_RS23570	COG0601	transmembrane transport
D7Y56_RS23575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7Y56_RS23580	COG0444	Belongs to the ABC transporter superfamily
D7Y56_RS23590	COG1472	Belongs to the glycosyl hydrolase 3 family
D7Y56_RS23605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS23610	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS23615	COG1120	ATPase activity
D7Y56_RS23620	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D7Y56_RS23655	COG1222	aaa ATPase
D7Y56_RS23770	COG1228	amidohydrolase
D7Y56_RS23780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7Y56_RS23800	COG2018	Roadblock/LC7 domain
D7Y56_RS23820	COG2018	Roadblock/LC7 domain
D7Y56_RS23825	COG5002	protein histidine kinase activity
D7Y56_RS23835	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7Y56_RS23840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D7Y56_RS23875	COG1414	Transcriptional regulator
D7Y56_RS23880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D7Y56_RS23885	COG0066	3-isopropylmalate dehydratase activity
D7Y56_RS23895	COG0776	regulation of translation
D7Y56_RS23905	COG1920	GTP binding
D7Y56_RS23915	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D7Y56_RS23920	COG1181	Belongs to the D-alanine--D-alanine ligase family
D7Y56_RS23940	COG0351	phosphomethylpyrimidine kinase
D7Y56_RS23945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D7Y56_RS23950	COG1461	Dihydroxyacetone kinase
D7Y56_RS23955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D7Y56_RS23960	COG0742	ribosomal rna small subunit methyltransferase
D7Y56_RS23965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D7Y56_RS23980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D7Y56_RS23985	COG0571	ribonuclease III activity
D7Y56_RS23990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D7Y56_RS23995	COG1733	regulation of RNA biosynthetic process
D7Y56_RS24005	COG2340	Cysteine-rich secretory protein family
D7Y56_RS24010	COG1254	Belongs to the acylphosphatase family
D7Y56_RS24030	COG0477	Major facilitator Superfamily
D7Y56_RS24035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D7Y56_RS24065	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D7Y56_RS24085	COG0228	four-way junction DNA binding
D7Y56_RS24090	COG1837	Belongs to the UPF0109 family
D7Y56_RS24095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D7Y56_RS24100	COG0336	Belongs to the RNA methyltransferase TrmD family
D7Y56_RS24105	COG0335	large ribosomal subunit rRNA binding
D7Y56_RS24110	COG0681	Belongs to the peptidase S26 family
D7Y56_RS24125	COG0681	Belongs to the peptidase S26 family
D7Y56_RS24130	COG1051	belongs to the nudix hydrolase family
D7Y56_RS24140	COG0792	nuclease activity
D7Y56_RS24155	COG1191	sigma factor activity
D7Y56_RS24170	COG0052	Belongs to the universal ribosomal protein uS2 family
D7Y56_RS24175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D7Y56_RS24180	COG0528	UMP kinase activity
D7Y56_RS24185	COG0233	cytoplasmic translational termination
D7Y56_RS24195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D7Y56_RS24210	COG3842	ATPase activity
D7Y56_RS24230	COG4181	ATPase activity
D7Y56_RS24235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D7Y56_RS24265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D7Y56_RS24285	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D7Y56_RS24290	COG3842	ATPase activity
D7Y56_RS24295	COG1176	ABC-type spermidine putrescine transport system, permease component I
D7Y56_RS24300	COG1177	transmembrane transport
D7Y56_RS24305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7Y56_RS24335	COG2508	Transcriptional regulator
D7Y56_RS24340	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS24355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D7Y56_RS24360	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D7Y56_RS24365	COG0750	zinc metalloprotease
D7Y56_RS24370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D7Y56_RS24385	COG0442	prolyl-tRNA aminoacylation
D7Y56_RS24405	COG0779	Required for maturation of 30S ribosomal subunits
D7Y56_RS24420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D7Y56_RS24430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D7Y56_RS24435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D7Y56_RS24460	COG0444	Belongs to the ABC transporter superfamily
D7Y56_RS24465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7Y56_RS24470	COG0601	transmembrane transport
D7Y56_RS24475	COG0747	negative chemotaxis
D7Y56_RS24480	COG0455	bacterial-type flagellum organization
D7Y56_RS24500	COG3266	domain, Protein
D7Y56_RS24505	COG1404	Belongs to the peptidase S8 family
D7Y56_RS24540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7Y56_RS24545	COG1674	ftsk spoiiie
D7Y56_RS24555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D7Y56_RS24560	COG1185	polyribonucleotide nucleotidyltransferase activity
D7Y56_RS24565	COG0612	Peptidase, M16
D7Y56_RS24570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D7Y56_RS24590	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D7Y56_RS24595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7Y56_RS24600	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D7Y56_RS24640	COG2770	Histidine kinase
D7Y56_RS24640	COG2208	phosphoserine phosphatase activity
D7Y56_RS24645	COG3437	response regulator, receiver
D7Y56_RS24645	COG2205	protein histidine kinase activity
D7Y56_RS24645	COG3850	Histidine kinase
D7Y56_RS24645	COG4999	Histidine kinase
D7Y56_RS24655	COG1674	ftsk spoiiie
D7Y56_RS24665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D7Y56_RS24675	COG1058	Belongs to the CinA family
D7Y56_RS24675	COG1546	Belongs to the CinA family
D7Y56_RS24680	COG1396	sequence-specific DNA binding
D7Y56_RS24685	COG0783	Belongs to the Dps family
D7Y56_RS24700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D7Y56_RS24705	COG1201	RNA secondary structure unwinding
D7Y56_RS24740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D7Y56_RS24770	COG0765	amino acid transport
D7Y56_RS24775	COG0765	amino acid transport
D7Y56_RS24780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7Y56_RS24785	COG1126	abc transporter atp-binding protein
D7Y56_RS24795	COG2205	protein histidine kinase activity
D7Y56_RS24800	COG2358	TRAP transporter, solute receptor (TAXI family
D7Y56_RS24820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D7Y56_RS24830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D7Y56_RS24835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D7Y56_RS24845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D7Y56_RS24880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D7Y56_RS24885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D7Y56_RS24890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7Y56_RS24905	COG0588	phosphoglycerate mutase activity
D7Y56_RS24925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D7Y56_RS24955	COG1129	ABC transporter
D7Y56_RS24960	COG2186	Transcriptional regulator
D7Y56_RS24965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7Y56_RS24990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7Y56_RS24995	COG4565	transcriptional regulatory protein
D7Y56_RS25000	COG3290	protein histidine kinase activity
D7Y56_RS25015	COG0372	Belongs to the citrate synthase family
D7Y56_RS25020	COG0372	Belongs to the citrate synthase family
D7Y56_RS25030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7Y56_RS25035	COG0612	Peptidase, M16
D7Y56_RS25050	COG1802	Transcriptional regulator
D7Y56_RS25055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7Y56_RS25075	COG1435	thymidine kinase activity
D7Y56_RS25110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D7Y56_RS25120	COG0745	RESPONSE REGULATOR receiver
D7Y56_RS25125	COG2205	protein histidine kinase activity
D7Y56_RS25150	COG0756	dUTP diphosphatase activity
D7Y56_RS25160	COG4591	ABC-type transport system involved in lipoprotein release permease component
D7Y56_RS25160	COG1136	(ABC) transporter
D7Y56_RS25190	COG0569	domain protein
D7Y56_RS25195	COG0531	amino acid
D7Y56_RS25200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7Y56_RS25220	COG1335	isochorismatase
D7Y56_RS25225	COG0702	epimerase
D7Y56_RS25230	COG3631	Ketosteroid isomerase-related protein
D7Y56_RS25240	COG0596	Alpha beta hydrolase
D7Y56_RS25265	COG1396	sequence-specific DNA binding
D7Y56_RS25270	COG1309	transcriptional regulator
D7Y56_RS25275	COG0604	alcohol dehydrogenase
D7Y56_RS25280	COG0596	Alpha beta hydrolase
D7Y56_RS25290	COG0515	serine threonine protein kinase
D7Y56_RS25310	COG2366	antibiotic biosynthetic process
D7Y56_RS25330	COG3903	Transcriptional regulator
D7Y56_RS25330	COG3629	intracellular signal transduction
D7Y56_RS25355	COG1937	Protein conserved in bacteria
D7Y56_RS25370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7Y56_RS25370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7Y56_RS25380	COG0210	DNA helicase
D7Y56_RS25390	COG1401	restriction endodeoxyribonuclease activity
D7Y56_RS25440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7Y56_RS25445	COG3226	Transcriptional regulator
D7Y56_RS25480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D7Y56_RS25495	COG2207	Transcriptional regulator
D7Y56_RS25500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7Y56_RS25505	COG1120	ATPase activity
D7Y56_RS25530	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D7Y56_RS25530	COG3291	Pkd domain containing protein
D7Y56_RS25550	COG0464	growth
D7Y56_RS25555	COG1404	Belongs to the peptidase S8 family
D7Y56_RS25560	COG1674	ftsk spoiiie
D7Y56_RS25625	COG1309	transcriptional regulator
D7Y56_RS25630	COG3046	protein related to deoxyribodipyrimidine photolyase
D7Y56_RS25635	COG1533	DNA photolyase activity
D7Y56_RS25650	COG1953	Uracil, thiamine, allantoin
D7Y56_RS25660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7Y56_RS25670	COG0714	Associated with various cellular activities
D7Y56_RS25685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7Y56_RS25700	COG1414	Transcriptional regulator
D7Y56_RS25705	COG2610	gluconate transmembrane transporter activity
D7Y56_RS25710	COG4948	Mandelate Racemase Muconate Lactonizing
D7Y56_RS25720	COG0583	DNA-binding transcription factor activity
D7Y56_RS25740	COG3585	molybdate ion transport
D7Y56_RS25780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7Y56_RS25815	COG1799	cell septum assembly
D7Y56_RS25840	COG2040	homocysteine
D7Y56_RS25850	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D7Y56_RS25860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D7Y56_RS25865	COG0531	amino acid
D7Y56_RS25875	COG1024	Enoyl-CoA hydratase
D7Y56_RS25895	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS25910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D7Y56_RS25910	COG2111	Na H antiporter
D7Y56_RS25915	COG1006	Multisubunit Na H antiporter MnhC subunit
D7Y56_RS25920	COG0651	ATP synthesis coupled electron transport
D7Y56_RS25935	COG1320	monovalent cation:proton antiporter activity
D7Y56_RS25960	COG0489	protein tyrosine kinase activity
D7Y56_RS26005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7Y56_RS26010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D7Y56_RS26020	COG0753	catalase activity
D7Y56_RS26055	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D7Y56_RS26060	COG0714	Associated with various cellular activities
D7Y56_RS26090	COG3251	PFAM MbtH domain protein
D7Y56_RS26120	COG1414	Transcriptional regulator
D7Y56_RS26125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7Y56_RS26135	COG3833	ABC-type maltose transport systems, permease component
D7Y56_RS26140	COG1653	transport
D7Y56_RS26200	COG0596	Alpha beta hydrolase
D7Y56_RS26230	COG4104	PAAR repeat-containing protein
D7Y56_RS26230	COG3209	COG3209 Rhs family protein
D7Y56_RS26240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D7Y56_RS26255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D7Y56_RS26260	COG1940	carbohydrate kinase activity
D7Y56_RS26275	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS26280	COG1175	transmembrane transport
D7Y56_RS26295	COG1501	Belongs to the glycosyl hydrolase 31 family
D7Y56_RS26340	COG1653	transport
D7Y56_RS26345	COG1175	transmembrane transport
D7Y56_RS26350	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS26365	COG3409	Peptidoglycan-binding domain 1 protein
D7Y56_RS26370	COG1940	carbohydrate kinase activity
D7Y56_RS26375	COG4213	ABC transporter substrate-binding protein
D7Y56_RS26385	COG4214	carbohydrate transport
D7Y56_RS26390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D7Y56_RS26395	COG0531	amino acid
D7Y56_RS26405	COG1316	TRANSCRIPTIONal
D7Y56_RS26420	COG1024	Enoyl-CoA hydratase
D7Y56_RS26420	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7Y56_RS26425	COG0183	Belongs to the thiolase family
D7Y56_RS26445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D7Y56_RS26450	COG0446	pyridine nucleotide-disulphide oxidoreductase
D7Y56_RS26460	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D7Y56_RS26465	COG3253	May function as heme-dependent peroxidase
D7Y56_RS26480	COG3220	belongs to the UPF0276 family
D7Y56_RS26500	COG4152	abc transporter atp-binding protein
D7Y56_RS26540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D7Y56_RS26545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7Y56_RS26550	COG2409	Drug exporters of the RND superfamily
D7Y56_RS26555	COG1309	transcriptional regulator
D7Y56_RS26560	COG0402	S-adenosylhomocysteine deaminase activity
D7Y56_RS26565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D7Y56_RS26570	COG1802	Transcriptional regulator
D7Y56_RS26585	COG0477	Major facilitator Superfamily
D7Y56_RS26600	COG1063	alcohol dehydrogenase
D7Y56_RS26605	COG0156	8-amino-7-oxononanoate synthase activity
D7Y56_RS26610	COG0583	DNA-binding transcription factor activity
D7Y56_RS26615	COG0346	lactoylglutathione lyase activity
D7Y56_RS26620	COG1072	(Pantothenic acid kinase))
D7Y56_RS26685	COG1175	transmembrane transport
D7Y56_RS26745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D7Y56_RS26760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7Y56_RS26765	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D7Y56_RS26785	COG0529	Catalyzes the synthesis of activated sulfate
D7Y56_RS26790	COG0175	sulfate reduction
D7Y56_RS26800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7Y56_RS26810	COG3284	Transcriptional regulator
D7Y56_RS26815	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS26835	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7Y56_RS26840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D7Y56_RS26845	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D7Y56_RS26850	COG0583	DNA-binding transcription factor activity
D7Y56_RS26860	COG0477	Major facilitator Superfamily
D7Y56_RS26875	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D7Y56_RS26880	COG1940	carbohydrate kinase activity
D7Y56_RS26885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7Y56_RS26890	COG2186	Transcriptional regulator
D7Y56_RS26905	COG3458	cephalosporin-C deacetylase activity
D7Y56_RS26915	COG4166	transmembrane transport
D7Y56_RS26925	COG0444	Belongs to the ABC transporter superfamily
D7Y56_RS26930	COG4608	Belongs to the ABC transporter superfamily
D7Y56_RS26935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7Y56_RS26980	COG1162	GTPase activity
D7Y56_RS27000	COG0028	Belongs to the TPP enzyme family
D7Y56_RS27030	COG1802	Transcriptional regulator
D7Y56_RS27055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D7Y56_RS27060	COG2252	PERMEase
D7Y56_RS27095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7Y56_RS27125	COG0435	Glutathione S-transferase
D7Y56_RS27140	COG2197	response regulator
D7Y56_RS27145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7Y56_RS27150	COG0318	PFAM AMP-dependent synthetase and ligase
D7Y56_RS27165	COG3960	tartronate-semialdehyde synthase activity
D7Y56_RS27175	COG0753	catalase activity
D7Y56_RS27180	COG2084	Dehydrogenase
D7Y56_RS27185	COG3622	Belongs to the hyi family
D7Y56_RS27200	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS27205	COG1175	transmembrane transport
D7Y56_RS27210	COG1653	transport
D7Y56_RS27215	COG2188	Transcriptional regulator
D7Y56_RS27235	COG2351	hydroxyisourate hydrolase activity
D7Y56_RS27245	COG2233	PERMEase
D7Y56_RS27255	COG2233	PERMEase
D7Y56_RS27325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D7Y56_RS27340	COG2197	response regulator
D7Y56_RS27345	COG4585	Histidine kinase
D7Y56_RS27355	COG1136	(ABC) transporter
D7Y56_RS27360	COG1414	Transcriptional regulator
D7Y56_RS27365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7Y56_RS27380	COG0656	L-ascorbic acid biosynthetic process
D7Y56_RS27415	COG0673	inositol 2-dehydrogenase activity
D7Y56_RS27420	COG2188	Transcriptional regulator
D7Y56_RS27435	COG1129	ABC transporter
D7Y56_RS27440	COG1940	carbohydrate kinase activity
D7Y56_RS27455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7Y56_RS27460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D7Y56_RS27485	COG1126	abc transporter atp-binding protein
D7Y56_RS27490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7Y56_RS27495	COG0765	amino acid transport
D7Y56_RS27500	COG0765	amino acid transport
D7Y56_RS27515	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS27530	COG2124	cytochrome p450
D7Y56_RS27540	COG2267	carboxylic ester hydrolase activity
D7Y56_RS27555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS27560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS27565	COG0019	diaminopimelate decarboxylase activity
D7Y56_RS27605	COG3321	synthase
D7Y56_RS27605	COG0604	alcohol dehydrogenase
D7Y56_RS27620	COG1136	(ABC) transporter
D7Y56_RS27620	COG0577	efflux transmembrane transporter activity
D7Y56_RS27635	COG2197	response regulator
D7Y56_RS27645	COG0405	Gamma-glutamyltransferase
D7Y56_RS27695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D7Y56_RS27700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7Y56_RS27740	COG1132	(ABC) transporter
D7Y56_RS27745	COG1132	(ABC) transporter
D7Y56_RS27765	COG2226	methyltransferase
D7Y56_RS27775	COG3851	Histidine kinase
D7Y56_RS27780	COG2197	response regulator
D7Y56_RS27785	COG2838	Isocitrate dehydrogenase
D7Y56_RS27790	COG0095	Lipoate-protein ligase
D7Y56_RS27805	COG0483	inositol monophosphate 1-phosphatase activity
D7Y56_RS27810	COG2860	membrane
D7Y56_RS27820	COG0778	Nitroreductase
D7Y56_RS27840	COG0431	NADPH-dependent FMN reductase
D7Y56_RS27890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D7Y56_RS27905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D7Y56_RS27920	COG1929	Belongs to the glycerate kinase type-1 family
D7Y56_RS27940	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7Y56_RS27975	COG0688	phosphatidylethanolamine metabolic process
D7Y56_RS27980	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS27990	COG2301	Belongs to the HpcH HpaI aldolase family
D7Y56_RS27995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7Y56_RS27995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7Y56_RS28000	COG0604	alcohol dehydrogenase
D7Y56_RS28020	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7Y56_RS28035	COG0596	Alpha beta hydrolase
D7Y56_RS28075	COG0583	DNA-binding transcription factor activity
D7Y56_RS28080	COG0667	Aldo Keto reductase
D7Y56_RS28085	COG2362	D-Aminopeptidase
D7Y56_RS28090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7Y56_RS28100	COG1619	proteins homologs of microcin C7 resistance protein MccF
D7Y56_RS28115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D7Y56_RS28170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D7Y56_RS28200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D7Y56_RS28205	COG1077	Cell shape determining protein MreB Mrl
D7Y56_RS28215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7Y56_RS28215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7Y56_RS28220	COG3619	membrane
D7Y56_RS28225	COG2154	pterin-4-alpha-carbinolamine dehydratase
D7Y56_RS28230	COG0656	L-ascorbic acid biosynthetic process
D7Y56_RS28270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D7Y56_RS28295	COG1129	ABC transporter
D7Y56_RS28300	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7Y56_RS28305	COG1879	ABC-type sugar transport system periplasmic component
D7Y56_RS28380	COG1609	Transcriptional regulator
D7Y56_RS28385	COG1129	ABC transporter
D7Y56_RS28390	COG1879	ABC-type sugar transport system periplasmic component
D7Y56_RS28395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7Y56_RS28400	COG1869	D-ribose catabolic process
D7Y56_RS28415	COG0346	lactoylglutathione lyase activity
D7Y56_RS28485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7Y56_RS28490	COG2353	YceI-like domain
D7Y56_RS28495	COG0210	DNA helicase
D7Y56_RS28500	COG0515	serine threonine protein kinase
D7Y56_RS28525	COG3209	COG3209 Rhs family protein
D7Y56_RS28675	COG3507	Belongs to the glycosyl hydrolase 43 family
D7Y56_RS28685	COG0596	Alpha beta hydrolase
D7Y56_RS28690	COG2770	Histidine kinase
D7Y56_RS28690	COG2208	phosphoserine phosphatase activity
D7Y56_RS28725	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS28730	COG4209	transmembrane transport
D7Y56_RS28745	COG1501	Belongs to the glycosyl hydrolase 31 family
D7Y56_RS28755	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS28765	COG4175	Glycine betaine
D7Y56_RS28765	COG0517	IMP dehydrogenase activity
D7Y56_RS28770	COG4176	ABC-type proline glycine betaine transport system permease component
D7Y56_RS28785	COG1136	(ABC) transporter
D7Y56_RS28815	COG1132	(ABC) transporter
D7Y56_RS28820	COG2124	cytochrome p450
D7Y56_RS28845	COG1940	carbohydrate kinase activity
D7Y56_RS28915	COG1486	melibiose metabolic process
D7Y56_RS28945	COG3012	SEC-C Motif Domain Protein
D7Y56_RS28970	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS29015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7Y56_RS29075	COG1793	dna ligase
D7Y56_RS29120	COG0488	(ABC) transporter
D7Y56_RS29135	COG1515	deoxyribonuclease V activity
D7Y56_RS29140	COG3268	Saccharopine dehydrogenase
D7Y56_RS29145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7Y56_RS29150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7Y56_RS29155	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS29160	COG0183	Belongs to the thiolase family
D7Y56_RS29165	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7Y56_RS29165	COG1024	Enoyl-CoA hydratase
D7Y56_RS29170	COG0789	Transcriptional regulator
D7Y56_RS29185	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS29195	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS29215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D7Y56_RS29225	COG0488	(ABC) transporter
D7Y56_RS29230	COG2183	response to ionizing radiation
D7Y56_RS29240	COG4977	sequence-specific DNA binding
D7Y56_RS29250	COG1024	Enoyl-CoA hydratase
D7Y56_RS29265	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D7Y56_RS29290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D7Y56_RS29310	COG1134	teichoic acid transport
D7Y56_RS29310	COG1388	LysM domain
D7Y56_RS29315	COG1562	ergosterol biosynthetic process
D7Y56_RS29325	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D7Y56_RS29335	COG1657	PFAM Prenyltransferase squalene oxidase
D7Y56_RS29360	COG2365	Tyrosine phosphatase family
D7Y56_RS29370	COG2755	lipolytic protein G-D-S-L family
D7Y56_RS29380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D7Y56_RS29420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D7Y56_RS29445	COG0725	ABC transporter, periplasmic molybdate-binding protein
D7Y56_RS29520	COG3958	Transketolase
D7Y56_RS29525	COG3959	Transketolase, thiamine diphosphate binding domain
D7Y56_RS29560	COG2197	response regulator
D7Y56_RS29575	COG2186	Transcriptional regulator
D7Y56_RS29580	COG0247	lactate metabolic process
D7Y56_RS29585	COG1139	Iron-sulfur cluster binding protein
D7Y56_RS29590	COG1556	Lactate utilization protein
D7Y56_RS29605	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS29610	COG1175	transmembrane transport
D7Y56_RS29640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D7Y56_RS29705	COG0768	penicillin binding
D7Y56_RS29710	COG2175	clavaminate synthase activity
D7Y56_RS29715	COG0010	Belongs to the arginase family
D7Y56_RS29720	COG0367	asparagine synthase
D7Y56_RS29735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D7Y56_RS29755	COG0747	negative chemotaxis
D7Y56_RS29760	COG0583	DNA-binding transcription factor activity
D7Y56_RS29765	COG4221	oxidoreductase activity
D7Y56_RS29785	COG0697	spore germination
D7Y56_RS29815	COG1295	ribonuclease BN
D7Y56_RS29820	COG0671	phosphoesterase, PA-phosphatase related
D7Y56_RS29840	COG2814	Major facilitator Superfamily
D7Y56_RS29840	COG0477	Major facilitator Superfamily
D7Y56_RS29855	COG2159	amidohydrolase
D7Y56_RS29860	COG2186	Transcriptional regulator
D7Y56_RS29915	COG0446	pyridine nucleotide-disulphide oxidoreductase
D7Y56_RS29915	COG1902	pentaerythritol trinitrate reductase activity
D7Y56_RS29950	COG1846	Transcriptional regulator
D7Y56_RS29955	COG2409	Drug exporters of the RND superfamily
D7Y56_RS29985	COG1122	ATPase activity
D7Y56_RS29990	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D7Y56_RS29995	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
D7Y56_RS30005	COG0589	response to stress
D7Y56_RS30075	COG1115	amino acid carrier protein
D7Y56_RS30100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS30130	COG0829	nickel cation binding
D7Y56_RS30135	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D7Y56_RS30145	COG0804	urea catabolic process
D7Y56_RS30150	COG0831	urea catabolic process
D7Y56_RS30150	COG0832	Belongs to the urease beta subunit family
D7Y56_RS30175	COG2175	clavaminate synthase activity
D7Y56_RS30210	COG0784	Response regulator, receiver
D7Y56_RS30215	COG4251	negative regulation of phosphorylation
D7Y56_RS30275	COG0494	nUDIX hydrolase
D7Y56_RS30315	COG1051	belongs to the nudix hydrolase family
D7Y56_RS30335	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D7Y56_RS30350	COG0302	gtp cyclohydrolase
D7Y56_RS30355	COG0602	queuosine metabolic process
D7Y56_RS30460	COG3547	Transposase (IS116 IS110 IS902 family)
D7Y56_RS30490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D7Y56_RS30520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D7Y56_RS30530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7Y56_RS30545	COG1012	belongs to the aldehyde dehydrogenase family
D7Y56_RS30555	COG1309	transcriptional regulator
D7Y56_RS30565	COG2072	flavoprotein involved in K transport
D7Y56_RS30585	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D7Y56_RS30595	COG0019	diaminopimelate decarboxylase activity
D7Y56_RS30610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D7Y56_RS30630	COG1132	(ABC) transporter
D7Y56_RS30640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D7Y56_RS30650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D7Y56_RS30680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7Y56_RS30685	COG1124	(ABC) transporter
D7Y56_RS30690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D7Y56_RS30730	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS30735	COG1175	transmembrane transport
D7Y56_RS30770	COG0784	Response regulator, receiver
D7Y56_RS30775	COG4251	negative regulation of phosphorylation
D7Y56_RS30780	COG4566	intracellular signal transduction
D7Y56_RS30785	COG1191	sigma factor activity
D7Y56_RS30790	COG2814	Major facilitator Superfamily
D7Y56_RS30835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D7Y56_RS30855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7Y56_RS30860	COG3275	phosphorelay sensor kinase activity
D7Y56_RS30890	COG0726	polysaccharide deacetylase
D7Y56_RS30935	COG0583	DNA-binding transcription factor activity
D7Y56_RS30950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D7Y56_RS30970	COG3360	Dodecin
D7Y56_RS30975	COG2182	Extracellular solute-binding protein
D7Y56_RS30990	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D7Y56_RS30995	COG0121	glutamine amidotransferase
D7Y56_RS31000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D7Y56_RS31005	COG3572	ergothioneine biosynthetic process
D7Y56_RS31020	COG1609	Transcriptional regulator
D7Y56_RS31030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7Y56_RS31035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7Y56_RS31055	COG0477	Major facilitator Superfamily
D7Y56_RS31080	COG4948	Mandelate Racemase Muconate Lactonizing
D7Y56_RS31090	COG1175	transmembrane transport
D7Y56_RS31100	COG2188	Transcriptional regulator
D7Y56_RS31110	COG1064	alcohol dehydrogenase
D7Y56_RS31120	COG0784	Response regulator, receiver
D7Y56_RS31125	COG4251	negative regulation of phosphorylation
D7Y56_RS31145	COG0783	Belongs to the Dps family
D7Y56_RS31150	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS31155	COG2391	methyltransferase activity
D7Y56_RS31165	COG0142	geranyltranstransferase activity
D7Y56_RS31180	COG5002	protein histidine kinase activity
D7Y56_RS31200	COG3537	Alpha-1,2-mannosidase
D7Y56_RS31210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D7Y56_RS31225	COG3507	Belongs to the glycosyl hydrolase 43 family
D7Y56_RS31240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7Y56_RS31245	COG0142	geranyltranstransferase activity
D7Y56_RS31265	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D7Y56_RS31300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D7Y56_RS31305	COG0596	Alpha beta hydrolase
D7Y56_RS31330	COG0697	spore germination
D7Y56_RS31340	COG2045	Belongs to the ComB family
D7Y56_RS31345	COG1335	isochorismatase
D7Y56_RS31360	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS31365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D7Y56_RS31375	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS31395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D7Y56_RS31445	COG1120	ATPase activity
D7Y56_RS31455	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D7Y56_RS31460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS31465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7Y56_RS31470	COG1120	ATPase activity
D7Y56_RS31475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D7Y56_RS31480	COG1132	(ABC) transporter
D7Y56_RS31490	COG1132	(ABC) transporter
D7Y56_RS31495	COG2207	Transcriptional regulator
D7Y56_RS31495	COG3708	Transcriptional regulator
D7Y56_RS31525	COG2382	esterase
D7Y56_RS31530	COG1414	Transcriptional regulator
D7Y56_RS31535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7Y56_RS31550	COG2223	nitrite transmembrane transporter activity
D7Y56_RS31560	COG0640	Transcriptional regulator
D7Y56_RS31565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7Y56_RS31580	COG0009	L-threonylcarbamoyladenylate synthase
D7Y56_RS31620	COG3458	cephalosporin-C deacetylase activity
D7Y56_RS31630	COG0656	L-ascorbic acid biosynthetic process
D7Y56_RS31660	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS31665	COG1960	acyl-CoA dehydrogenase activity
D7Y56_RS31705	COG2890	protein-(glutamine-N5) methyltransferase activity
D7Y56_RS31715	COG1796	DNA polymerase
D7Y56_RS31715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D7Y56_RS31855	COG2018	Roadblock/LC7 domain
D7Y56_RS31880	COG1024	Enoyl-CoA hydratase
D7Y56_RS31885	COG1070	Carbohydrate kinase
D7Y56_RS31890	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS31890	COG3347	Dehydrogenase
D7Y56_RS31895	COG4952	isomerase
D7Y56_RS31900	COG0640	Transcriptional regulator
D7Y56_RS31915	COG1357	PFAM Pentapeptide repeats (8 copies)
D7Y56_RS31920	COG2755	lipolytic protein G-D-S-L family
D7Y56_RS31930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7Y56_RS31940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D7Y56_RS31960	COG2340	Cysteine-rich secretory protein family
D7Y56_RS31970	COG0277	FAD linked oxidase domain protein
D7Y56_RS31985	COG1846	Transcriptional regulator
D7Y56_RS31990	COG1764	response to oxidative stress
D7Y56_RS32025	COG0181	hydroxymethylbilane synthase activity
D7Y56_RS32050	COG0739	heme binding
D7Y56_RS32120	COG4124	Belongs to the glycosyl hydrolase 26 family
D7Y56_RS32120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D7Y56_RS32140	COG2304	oxidoreductase activity
D7Y56_RS32145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7Y56_RS32180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D7Y56_RS32215	COG0583	DNA-binding transcription factor activity
D7Y56_RS32220	COG2814	Major facilitator Superfamily
D7Y56_RS32230	COG1032	radical SAM domain protein
D7Y56_RS32235	COG0367	asparagine synthase
D7Y56_RS32275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D7Y56_RS32280	COG0010	Belongs to the arginase family
D7Y56_RS32315	COG1233	COG1233 Phytoene dehydrogenase and related
D7Y56_RS32320	COG2130	NADP-dependent
D7Y56_RS32335	COG0019	diaminopimelate decarboxylase activity
D7Y56_RS32400	COG0189	ligase activity
D7Y56_RS32405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D7Y56_RS32410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D7Y56_RS32415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7Y56_RS32420	COG3959	Transketolase, thiamine diphosphate binding domain
D7Y56_RS32425	COG3958	Transketolase
D7Y56_RS32440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS32455	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D7Y56_RS32460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS32485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS32505	COG2124	cytochrome p450
D7Y56_RS32525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D7Y56_RS32530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D7Y56_RS32540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS32545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D7Y56_RS32550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7Y56_RS32580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D7Y56_RS32590	COG2197	response regulator
D7Y56_RS32595	COG2423	ornithine cyclodeaminase activity
D7Y56_RS32600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D7Y56_RS32625	COG0395	ABC-type sugar transport system, permease component
D7Y56_RS32635	COG1653	transport
D7Y56_RS32640	COG1609	Transcriptional regulator
D7Y56_RS32690	COG0432	Pfam Uncharacterised protein family UPF0047
D7Y56_RS32765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D7Y56_RS32795	COG0069	glutamate synthase activity
D7Y56_RS32860	COG2124	cytochrome p450
D7Y56_RS32945	COG1028	Short-chain dehydrogenase reductase Sdr
D7Y56_RS32955	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit