locus-tag	class	description
A6E92_RS00115	COG0477	Major facilitator Superfamily
A6E92_RS00150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6E92_RS00160	COG1120	ATPase activity
A6E92_RS00165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS00215	COG2367	Beta-lactamase
A6E92_RS00235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6E92_RS00245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6E92_RS00250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6E92_RS00255	COG0395	ABC-type sugar transport system, permease component
A6E92_RS00260	COG1175	transmembrane transport
A6E92_RS00300	COG2890	protein-(glutamine-N5) methyltransferase activity
A6E92_RS00310	COG1891	lyase activity
A6E92_RS00325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A6E92_RS00345	COG0142	geranyltranstransferase activity
A6E92_RS00365	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A6E92_RS00400	COG0009	L-threonylcarbamoyladenylate synthase
A6E92_RS00415	COG0488	(ABC) transporter
A6E92_RS00445	COG2340	Cysteine-rich secretory protein family
A6E92_RS00455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6E92_RS00460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6E92_RS00475	COG1595	DNA-templated transcription, initiation
A6E92_RS00515	COG1024	Enoyl-CoA hydratase
A6E92_RS00540	COG2018	Roadblock/LC7 domain
A6E92_RS00555	COG0640	Transcriptional regulator
A6E92_RS00560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6E92_RS00565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6E92_RS00595	COG3239	Fatty acid desaturase
A6E92_RS00600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6E92_RS00610	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6E92_RS00620	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS00665	COG3250	beta-galactosidase activity
A6E92_RS00715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6E92_RS00720	COG1121	(ABC) transporter
A6E92_RS00750	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6E92_RS00805	COG2223	nitrite transmembrane transporter activity
A6E92_RS00810	COG0243	molybdopterin cofactor binding
A6E92_RS00815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6E92_RS00815	COG2146	nitrite reductase [NAD(P)H] activity
A6E92_RS00820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6E92_RS00820	COG2146	nitrite reductase [NAD(P)H] activity
A6E92_RS00835	COG5001	Diguanylate cyclase
A6E92_RS00835	COG3300	MHYT domain
A6E92_RS00845	COG5297	Belongs to the glycosyl hydrolase family 6
A6E92_RS00880	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A6E92_RS00895	COG0693	protein deglycase activity
A6E92_RS00900	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A6E92_RS00915	COG1278	Cold shock
A6E92_RS01000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6E92_RS01000	COG1796	DNA polymerase
A6E92_RS01045	COG4608	Belongs to the ABC transporter superfamily
A6E92_RS01050	COG0444	Belongs to the ABC transporter superfamily
A6E92_RS01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E92_RS01060	COG0601	transmembrane transport
A6E92_RS01075	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS01080	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS01100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E92_RS01110	COG0517	IMP dehydrogenase activity
A6E92_RS01110	COG1125	glycine betaine transport
A6E92_RS01130	COG1174	glycine betaine transport
A6E92_RS01135	COG1174	glycine betaine transport
A6E92_RS01175	COG0297	glycogen (starch) synthase activity
A6E92_RS01175	COG0438	transferase activity, transferring glycosyl groups
A6E92_RS01200	COG0438	transferase activity, transferring glycosyl groups
A6E92_RS01245	COG1132	(ABC) transporter
A6E92_RS01250	COG1132	(ABC) transporter
A6E92_RS01275	COG1120	ATPase activity
A6E92_RS01280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS01285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS01305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6E92_RS01310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6E92_RS01315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6E92_RS01320	COG0254	rRNA binding
A6E92_RS01330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6E92_RS01335	COG0477	Major facilitator Superfamily
A6E92_RS01345	COG1120	ATPase activity
A6E92_RS01390	COG0431	NADPH-dependent FMN reductase
A6E92_RS01405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6E92_RS01410	COG4608	Belongs to the ABC transporter superfamily
A6E92_RS01420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E92_RS01425	COG0601	transmembrane transport
A6E92_RS01490	COG1136	(ABC) transporter
A6E92_RS01490	COG0577	efflux transmembrane transporter activity
A6E92_RS01510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6E92_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS01595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6E92_RS01610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6E92_RS01625	COG1834	amidinotransferase
A6E92_RS01685	COG0601	transmembrane transport
A6E92_RS01690	COG0747	negative chemotaxis
A6E92_RS01695	COG1120	ATPase activity
A6E92_RS01700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS01710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS01735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6E92_RS01835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6E92_RS01840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6E92_RS01850	COG1609	Transcriptional regulator
A6E92_RS01865	COG3572	ergothioneine biosynthetic process
A6E92_RS01870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6E92_RS01875	COG0121	glutamine amidotransferase
A6E92_RS01880	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A6E92_RS01900	COG3360	Dodecin
A6E92_RS01915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6E92_RS01920	COG2423	ornithine cyclodeaminase activity
A6E92_RS01925	COG2197	response regulator
A6E92_RS01935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A6E92_RS01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS01970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6E92_RS01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS01985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6E92_RS01990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6E92_RS02005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6E92_RS02010	COG1053	succinate dehydrogenase
A6E92_RS02020	COG0583	DNA-binding transcription factor activity
A6E92_RS02095	COG3275	phosphorelay sensor kinase activity
A6E92_RS02100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E92_RS02120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6E92_RS02155	COG1191	sigma factor activity
A6E92_RS02160	COG2201	protein-glutamate methylesterase activity
A6E92_RS02165	COG4251	negative regulation of phosphorylation
A6E92_RS02170	COG0784	Response regulator, receiver
A6E92_RS02205	COG1652	LysM domain
A6E92_RS02225	COG1175	transmembrane transport
A6E92_RS02230	COG0395	ABC-type sugar transport system, permease component
A6E92_RS02265	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6E92_RS02270	COG2837	iron assimilation
A6E92_RS02295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A6E92_RS02310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6E92_RS02315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6E92_RS02320	COG2080	2 iron, 2 sulfur cluster binding
A6E92_RS02335	COG2124	cytochrome p450
A6E92_RS02340	COG2130	NADP-dependent
A6E92_RS02345	COG1233	COG1233 Phytoene dehydrogenase and related
A6E92_RS02375	COG4977	sequence-specific DNA binding
A6E92_RS02405	COG1846	Transcriptional regulator
A6E92_RS02410	COG2409	Drug exporters of the RND superfamily
A6E92_RS02425	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6E92_RS02425	COG1902	pentaerythritol trinitrate reductase activity
A6E92_RS02475	COG0829	nickel cation binding
A6E92_RS02480	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A6E92_RS02485	COG0830	nickel cation binding
A6E92_RS02490	COG0804	urea catabolic process
A6E92_RS02495	COG0832	Belongs to the urease beta subunit family
A6E92_RS02495	COG0831	urea catabolic process
A6E92_RS02505	COG0831	urea catabolic process
A6E92_RS02535	COG0714	Associated with various cellular activities
A6E92_RS02555	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A6E92_RS02560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A6E92_RS02565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A6E92_RS02575	COG1316	TRANSCRIPTIONal
A6E92_RS02595	COG2079	MmgE PrpD family protein
A6E92_RS02600	COG3800	Transcriptional regulator
A6E92_RS02600	COG1396	sequence-specific DNA binding
A6E92_RS02650	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6E92_RS02655	COG0604	alcohol dehydrogenase
A6E92_RS02655	COG3321	synthase
A6E92_RS02665	COG3321	synthase
A6E92_RS02665	COG0604	alcohol dehydrogenase
A6E92_RS02680	COG0156	8-amino-7-oxononanoate synthase activity
A6E92_RS02690	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS02710	COG1132	(ABC) transporter
A6E92_RS02715	COG2226	methyltransferase
A6E92_RS02750	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A6E92_RS02750	COG1672	PFAM Archaeal ATPase
A6E92_RS02770	COG1556	Lactate utilization protein
A6E92_RS02775	COG1139	Iron-sulfur cluster binding protein
A6E92_RS02780	COG0247	lactate metabolic process
A6E92_RS02790	COG3851	Histidine kinase
A6E92_RS02795	COG2197	response regulator
A6E92_RS02805	COG3511	phospholipase C
A6E92_RS02825	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS02840	COG3321	synthase
A6E92_RS02840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6E92_RS02840	COG0300	oxidoreductase activity
A6E92_RS02840	COG4221	oxidoreductase activity
A6E92_RS02845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6E92_RS02860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6E92_RS02875	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS02900	COG1215	transferase activity, transferring glycosyl groups
A6E92_RS02975	COG3959	Transketolase, thiamine diphosphate binding domain
A6E92_RS02980	COG3958	Transketolase
A6E92_RS03005	COG1116	anion transmembrane transporter activity
A6E92_RS03015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6E92_RS03020	COG1609	Transcriptional regulator
A6E92_RS03060	COG3467	pyridoxamine 5'-phosphate
A6E92_RS03105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6E92_RS03115	COG2755	lipolytic protein G-D-S-L family
A6E92_RS03125	COG2365	Tyrosine phosphatase family
A6E92_RS03150	COG1657	PFAM Prenyltransferase squalene oxidase
A6E92_RS03160	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A6E92_RS03170	COG1562	ergosterol biosynthetic process
A6E92_RS03175	COG1388	LysM domain
A6E92_RS03175	COG1134	teichoic acid transport
A6E92_RS03190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6E92_RS03220	COG4106	trans-aconitate 2-methyltransferase activity
A6E92_RS03225	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A6E92_RS03240	COG1024	Enoyl-CoA hydratase
A6E92_RS03250	COG4977	sequence-specific DNA binding
A6E92_RS03260	COG2183	response to ionizing radiation
A6E92_RS03265	COG0488	(ABC) transporter
A6E92_RS03285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6E92_RS03310	COG0789	Transcriptional regulator
A6E92_RS03315	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6E92_RS03315	COG1024	Enoyl-CoA hydratase
A6E92_RS03320	COG0183	Belongs to the thiolase family
A6E92_RS03325	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS03330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6E92_RS03335	COG3268	Saccharopine dehydrogenase
A6E92_RS03340	COG1515	deoxyribonuclease V activity
A6E92_RS03355	COG0488	(ABC) transporter
A6E92_RS03360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6E92_RS03415	COG3285	dna ligase
A6E92_RS03415	COG1793	dna ligase
A6E92_RS03420	COG1793	dna ligase
A6E92_RS03430	COG1366	Belongs to the anti-sigma-factor antagonist family
A6E92_RS03440	COG2770	Histidine kinase
A6E92_RS03440	COG2208	phosphoserine phosphatase activity
A6E92_RS03475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6E92_RS03500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6E92_RS03550	COG0483	inositol monophosphate 1-phosphatase activity
A6E92_RS03555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6E92_RS03560	COG5635	Nacht domain
A6E92_RS03560	COG2319	Wd-40 repeat
A6E92_RS03580	COG3012	SEC-C Motif Domain Protein
A6E92_RS03620	COG1486	melibiose metabolic process
A6E92_RS03625	COG2124	cytochrome p450
A6E92_RS03650	COG1846	Transcriptional regulator
A6E92_RS03675	COG1940	carbohydrate kinase activity
A6E92_RS03685	COG1070	Carbohydrate kinase
A6E92_RS03700	COG0569	domain protein
A6E92_RS03700	COG2985	domain, Protein
A6E92_RS03715	COG2124	cytochrome p450
A6E92_RS03725	COG4176	ABC-type proline glycine betaine transport system permease component
A6E92_RS03730	COG4175	Glycine betaine
A6E92_RS03730	COG0517	IMP dehydrogenase activity
A6E92_RS03740	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS03760	COG0745	RESPONSE REGULATOR receiver
A6E92_RS03765	COG5002	protein histidine kinase activity
A6E92_RS03790	COG1869	D-ribose catabolic process
A6E92_RS03795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E92_RS03805	COG1129	ABC transporter
A6E92_RS03860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6E92_RS03880	COG0673	inositol 2-dehydrogenase activity
A6E92_RS03890	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6E92_RS03895	COG1129	ABC transporter
A6E92_RS03905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6E92_RS03910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6E92_RS03920	COG0583	DNA-binding transcription factor activity
A6E92_RS03930	COG0656	L-ascorbic acid biosynthetic process
A6E92_RS03940	COG4106	trans-aconitate 2-methyltransferase activity
A6E92_RS03950	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6E92_RS03960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E92_RS03960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E92_RS03980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6E92_RS04005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A6E92_RS04035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6E92_RS04050	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6E92_RS04060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6E92_RS04065	COG2362	D-Aminopeptidase
A6E92_RS04075	COG0667	Aldo Keto reductase
A6E92_RS04080	COG0583	DNA-binding transcription factor activity
A6E92_RS04110	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6E92_RS04130	COG0604	alcohol dehydrogenase
A6E92_RS04135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6E92_RS04135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6E92_RS04140	COG2301	Belongs to the HpcH HpaI aldolase family
A6E92_RS04150	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS04155	COG0688	phosphatidylethanolamine metabolic process
A6E92_RS04180	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6E92_RS04185	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6E92_RS04205	COG1929	Belongs to the glycerate kinase type-1 family
A6E92_RS04220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6E92_RS04260	COG2197	response regulator
A6E92_RS04265	COG1024	Enoyl-CoA hydratase
A6E92_RS04270	COG1131	(ABC) transporter
A6E92_RS04280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6E92_RS04290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6E92_RS04295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6E92_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS04335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS04340	COG1024	Enoyl-CoA hydratase
A6E92_RS04345	COG2267	carboxylic ester hydrolase activity
A6E92_RS04375	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A6E92_RS04390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6E92_RS04410	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS04415	COG1024	Enoyl-CoA hydratase
A6E92_RS04430	COG0095	Lipoate-protein ligase
A6E92_RS04440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6E92_RS04450	COG2838	Isocitrate dehydrogenase
A6E92_RS04475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6E92_RS04480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6E92_RS04515	COG0405	Gamma-glutamyltransferase
A6E92_RS04530	COG1376	ErfK ybiS ycfS ynhG family protein
A6E92_RS04540	COG0765	amino acid transport
A6E92_RS04545	COG0765	amino acid transport
A6E92_RS04550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E92_RS04555	COG1126	abc transporter atp-binding protein
A6E92_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS04590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A6E92_RS04595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6E92_RS04605	COG1940	carbohydrate kinase activity
A6E92_RS04610	COG1129	ABC transporter
A6E92_RS04625	COG2188	Transcriptional regulator
A6E92_RS04630	COG0673	inositol 2-dehydrogenase activity
A6E92_RS04640	COG2197	response regulator
A6E92_RS04675	COG0789	Transcriptional regulator
A6E92_RS04690	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A6E92_RS04700	COG0789	Transcriptional regulator
A6E92_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS04715	COG0656	L-ascorbic acid biosynthetic process
A6E92_RS04720	COG4266	Belongs to the allantoicase family
A6E92_RS04725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6E92_RS04730	COG1414	Transcriptional regulator
A6E92_RS04745	COG4251	negative regulation of phosphorylation
A6E92_RS04750	COG2197	response regulator
A6E92_RS04765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6E92_RS04810	COG2233	PERMEase
A6E92_RS04820	COG2233	PERMEase
A6E92_RS04830	COG2351	hydroxyisourate hydrolase activity
A6E92_RS04850	COG2706	6-phosphogluconolactonase activity
A6E92_RS04855	COG2188	Transcriptional regulator
A6E92_RS04865	COG1175	transmembrane transport
A6E92_RS04870	COG0395	ABC-type sugar transport system, permease component
A6E92_RS04875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6E92_RS04885	COG3622	Belongs to the hyi family
A6E92_RS04890	COG2084	Dehydrogenase
A6E92_RS04895	COG0753	catalase activity
A6E92_RS04910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6E92_RS04915	COG0436	Aminotransferase
A6E92_RS04925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6E92_RS04935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS04945	COG3903	Transcriptional regulator
A6E92_RS04945	COG3629	intracellular signal transduction
A6E92_RS04960	COG3960	tartronate-semialdehyde synthase activity
A6E92_RS04980	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS04985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6E92_RS04990	COG2197	response regulator
A6E92_RS05000	COG0435	Glutathione S-transferase
A6E92_RS05030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6E92_RS05055	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A6E92_RS05055	COG3608	succinylglutamate desuccinylase aspartoacylase
A6E92_RS05060	COG2252	PERMEase
A6E92_RS05065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6E92_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS05095	COG1309	transcriptional regulator
A6E92_RS05100	COG1802	Transcriptional regulator
A6E92_RS05120	COG0028	Belongs to the TPP enzyme family
A6E92_RS05145	COG1162	GTPase activity
A6E92_RS05195	COG0183	Belongs to the thiolase family
A6E92_RS05200	COG0583	DNA-binding transcription factor activity
A6E92_RS05205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6E92_RS05210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A6E92_RS05215	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6E92_RS05235	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS05260	COG0175	sulfate reduction
A6E92_RS05265	COG0529	Catalyzes the synthesis of activated sulfate
A6E92_RS05285	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A6E92_RS05290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6E92_RS05300	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6E92_RS05305	COG1132	(ABC) transporter
A6E92_RS05310	COG1132	(ABC) transporter
A6E92_RS05345	COG1175	transmembrane transport
A6E92_RS05390	COG2723	6-phospho-beta-galactosidase activity
A6E92_RS05405	COG1072	(Pantothenic acid kinase))
A6E92_RS05410	COG0346	lactoylglutathione lyase activity
A6E92_RS05420	COG0583	DNA-binding transcription factor activity
A6E92_RS05425	COG0156	8-amino-7-oxononanoate synthase activity
A6E92_RS05430	COG1063	alcohol dehydrogenase
A6E92_RS05520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E92_RS05525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6E92_RS05565	COG0546	phosphoglycolate phosphatase activity
A6E92_RS05570	COG2376	Dihydroxyacetone kinase
A6E92_RS05575	COG2376	Dihydroxyacetone kinase
A6E92_RS05600	COG3220	belongs to the UPF0276 family
A6E92_RS05610	COG0596	Alpha beta hydrolase
A6E92_RS05615	COG3253	May function as heme-dependent peroxidase
A6E92_RS05620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A6E92_RS05630	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6E92_RS05635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6E92_RS05655	COG0183	Belongs to the thiolase family
A6E92_RS05660	COG1024	Enoyl-CoA hydratase
A6E92_RS05660	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6E92_RS05665	COG1316	TRANSCRIPTIONal
A6E92_RS05675	COG0531	amino acid
A6E92_RS05680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6E92_RS05685	COG4214	carbohydrate transport
A6E92_RS05695	COG4213	ABC transporter substrate-binding protein
A6E92_RS05700	COG1940	carbohydrate kinase activity
A6E92_RS05705	COG0395	ABC-type sugar transport system, permease component
A6E92_RS05710	COG1175	transmembrane transport
A6E92_RS05715	COG1653	transport
A6E92_RS05725	COG0406	alpha-ribazole phosphatase activity
A6E92_RS05750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6E92_RS05760	COG2267	carboxylic ester hydrolase activity
A6E92_RS05765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6E92_RS05790	COG0513	Belongs to the DEAD box helicase family
A6E92_RS05795	COG1278	Cold shock
A6E92_RS05840	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS05875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6E92_RS05880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6E92_RS05885	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6E92_RS05920	COG0489	protein tyrosine kinase activity
A6E92_RS05925	COG0297	glycogen (starch) synthase activity
A6E92_RS05940	COG1320	monovalent cation:proton antiporter activity
A6E92_RS05955	COG0651	ATP synthesis coupled electron transport
A6E92_RS05960	COG1006	Multisubunit Na H antiporter MnhC subunit
A6E92_RS05965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6E92_RS05965	COG2111	Na H antiporter
A6E92_RS05995	COG1024	Enoyl-CoA hydratase
A6E92_RS06005	COG0531	amino acid
A6E92_RS06010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6E92_RS06020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6E92_RS06030	COG2040	homocysteine
A6E92_RS06050	COG1799	cell septum assembly
A6E92_RS06060	COG0586	Pfam SNARE associated Golgi protein
A6E92_RS06070	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS06075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS06090	COG2010	Cytochrome c
A6E92_RS06090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6E92_RS06095	COG1802	Transcriptional regulator
A6E92_RS06100	COG3938	Belongs to the proline racemase family
A6E92_RS06120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E92_RS06125	COG3291	Pkd domain containing protein
A6E92_RS06135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6E92_RS06140	COG1280	lysine exporter protein (LysE YggA)
A6E92_RS06145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6E92_RS06150	COG0505	Belongs to the CarA family
A6E92_RS06175	COG2192	nodulation
A6E92_RS06250	COG1674	ftsk spoiiie
A6E92_RS06260	COG0464	growth
A6E92_RS06310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6E92_RS06315	COG0531	amino acid
A6E92_RS06320	COG0569	domain protein
A6E92_RS06355	COG0756	dUTP diphosphatase activity
A6E92_RS06380	COG2205	protein histidine kinase activity
A6E92_RS06385	COG0745	RESPONSE REGULATOR receiver
A6E92_RS06395	COG0483	inositol monophosphate 1-phosphatase activity
A6E92_RS06400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6E92_RS06435	COG1435	thymidine kinase activity
A6E92_RS06455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E92_RS06460	COG1802	Transcriptional regulator
A6E92_RS06475	COG0612	Peptidase, M16
A6E92_RS06480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6E92_RS06490	COG0372	Belongs to the citrate synthase family
A6E92_RS06505	COG3290	protein histidine kinase activity
A6E92_RS06510	COG4565	transcriptional regulatory protein
A6E92_RS06515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E92_RS06540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6E92_RS06545	COG2186	Transcriptional regulator
A6E92_RS06550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6E92_RS06580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6E92_RS06610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6E92_RS06615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6E92_RS06620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6E92_RS06660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6E92_RS06670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6E92_RS06675	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6E92_RS06685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6E92_RS06705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6E92_RS06710	COG2358	TRAP transporter, solute receptor (TAXI family
A6E92_RS06715	COG2205	protein histidine kinase activity
A6E92_RS06720	COG0745	RESPONSE REGULATOR receiver
A6E92_RS06725	COG1126	abc transporter atp-binding protein
A6E92_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E92_RS06735	COG0765	amino acid transport
A6E92_RS06740	COG0765	amino acid transport
A6E92_RS06745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6E92_RS06755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E92_RS06770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6E92_RS06810	COG2207	Transcriptional regulator
A6E92_RS06810	COG1917	Cupin 2, conserved barrel domain protein
A6E92_RS06815	COG1201	RNA secondary structure unwinding
A6E92_RS06820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6E92_RS06825	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS06840	COG0783	Belongs to the Dps family
A6E92_RS06845	COG1396	sequence-specific DNA binding
A6E92_RS06850	COG1546	Belongs to the CinA family
A6E92_RS06850	COG1058	Belongs to the CinA family
A6E92_RS06860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6E92_RS06870	COG1674	ftsk spoiiie
A6E92_RS06880	COG2205	protein histidine kinase activity
A6E92_RS06880	COG3437	response regulator, receiver
A6E92_RS06880	COG3850	Histidine kinase
A6E92_RS06880	COG4999	Histidine kinase
A6E92_RS06885	COG2770	Histidine kinase
A6E92_RS06885	COG2208	phosphoserine phosphatase activity
A6E92_RS06910	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A6E92_RS06915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6E92_RS06920	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A6E92_RS06940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6E92_RS06945	COG0612	Peptidase, M16
A6E92_RS06950	COG1185	polyribonucleotide nucleotidyltransferase activity
A6E92_RS06955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6E92_RS06965	COG1674	ftsk spoiiie
A6E92_RS06980	COG1404	Belongs to the peptidase S8 family
A6E92_RS06995	COG1404	Belongs to the peptidase S8 family
A6E92_RS07000	COG3266	domain, Protein
A6E92_RS07020	COG0455	bacterial-type flagellum organization
A6E92_RS07025	COG0747	negative chemotaxis
A6E92_RS07030	COG0601	transmembrane transport
A6E92_RS07035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E92_RS07070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6E92_RS07075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6E92_RS07085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6E92_RS07100	COG0779	Required for maturation of 30S ribosomal subunits
A6E92_RS07120	COG0442	prolyl-tRNA aminoacylation
A6E92_RS07135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6E92_RS07140	COG0750	zinc metalloprotease
A6E92_RS07145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6E92_RS07155	COG2239	Acts as a magnesium transporter
A6E92_RS07160	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS07165	COG2508	Transcriptional regulator
A6E92_RS07195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E92_RS07200	COG1177	transmembrane transport
A6E92_RS07205	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6E92_RS07210	COG3842	ATPase activity
A6E92_RS07215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6E92_RS07235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6E92_RS07255	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS07265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6E92_RS07270	COG1136	(ABC) transporter
A6E92_RS07285	COG3842	ATPase activity
A6E92_RS07300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6E92_RS07310	COG0233	cytoplasmic translational termination
A6E92_RS07315	COG0528	UMP kinase activity
A6E92_RS07320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6E92_RS07325	COG0052	Belongs to the universal ribosomal protein uS2 family
A6E92_RS07340	COG1191	sigma factor activity
A6E92_RS07355	COG0792	nuclease activity
A6E92_RS07370	COG0681	Belongs to the peptidase S26 family
A6E92_RS07385	COG0681	Belongs to the peptidase S26 family
A6E92_RS07390	COG0335	large ribosomal subunit rRNA binding
A6E92_RS07395	COG0336	Belongs to the RNA methyltransferase TrmD family
A6E92_RS07400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6E92_RS07405	COG1837	Belongs to the UPF0109 family
A6E92_RS07410	COG0228	four-way junction DNA binding
A6E92_RS07430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6E92_RS07465	COG0477	Major facilitator Superfamily
A6E92_RS07470	COG1196	nuclear chromosome segregation
A6E92_RS07485	COG1254	Belongs to the acylphosphatase family
A6E92_RS07490	COG2340	Cysteine-rich secretory protein family
A6E92_RS07520	COG2188	Transcriptional regulator
A6E92_RS07540	COG1733	regulation of RNA biosynthetic process
A6E92_RS07545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6E92_RS07550	COG0571	ribonuclease III activity
A6E92_RS07555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6E92_RS07570	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6E92_RS07575	COG0742	ribosomal rna small subunit methyltransferase
A6E92_RS07580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6E92_RS07585	COG1461	Dihydroxyacetone kinase
A6E92_RS07590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6E92_RS07595	COG0351	phosphomethylpyrimidine kinase
A6E92_RS07610	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6E92_RS07615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6E92_RS07625	COG1920	GTP binding
A6E92_RS07635	COG0776	regulation of translation
A6E92_RS07645	COG0066	3-isopropylmalate dehydratase activity
A6E92_RS07650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6E92_RS07655	COG1414	Transcriptional regulator
A6E92_RS07690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6E92_RS07695	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6E92_RS07705	COG5002	protein histidine kinase activity
A6E92_RS07710	COG2018	Roadblock/LC7 domain
A6E92_RS07730	COG2018	Roadblock/LC7 domain
A6E92_RS07750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6E92_RS07755	COG0366	Alpha amylase catalytic
A6E92_RS07755	COG1470	cell adhesion involved in biofilm formation
A6E92_RS07775	COG4607	ABC-type enterochelin transport system periplasmic component
A6E92_RS07780	COG1120	ATPase activity
A6E92_RS07785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS07790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS07815	COG1733	regulation of RNA biosynthetic process
A6E92_RS07830	COG0492	ferredoxin-NADP+ reductase activity
A6E92_RS07855	COG3708	Transcriptional regulator
A6E92_RS07855	COG2207	Transcriptional regulator
A6E92_RS07870	COG1472	Belongs to the glycosyl hydrolase 3 family
A6E92_RS07880	COG0444	Belongs to the ABC transporter superfamily
A6E92_RS07885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E92_RS07890	COG0601	transmembrane transport
A6E92_RS07895	COG4608	Belongs to the ABC transporter superfamily
A6E92_RS07910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6E92_RS07920	COG2957	Belongs to the agmatine deiminase family
A6E92_RS07925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6E92_RS07930	COG0473	3-isopropylmalate dehydrogenase activity
A6E92_RS07940	COG2130	NADP-dependent
A6E92_RS07955	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS07960	COG0506	proline dehydrogenase activity
A6E92_RS07975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6E92_RS07980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6E92_RS07985	COG0440	acetolactate synthase activity
A6E92_RS08005	COG0667	Aldo Keto reductase
A6E92_RS08010	COG2133	pyrroloquinoline quinone binding
A6E92_RS08025	COG2409	Drug exporters of the RND superfamily
A6E92_RS08035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6E92_RS08045	COG0154	amidase activity
A6E92_RS08050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6E92_RS08060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6E92_RS08070	COG4221	oxidoreductase activity
A6E92_RS08090	COG0482	sulfurtransferase activity
A6E92_RS08120	COG2860	membrane
A6E92_RS08125	COG4608	Belongs to the ABC transporter superfamily
A6E92_RS08135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E92_RS08140	COG0601	transmembrane transport
A6E92_RS08145	COG4166	transmembrane transport
A6E92_RS08165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6E92_RS08170	COG0509	glycine decarboxylation via glycine cleavage system
A6E92_RS08175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6E92_RS08180	COG1760	l-serine dehydratase
A6E92_RS08210	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS08245	COG0823	Involved in the tonB-independent uptake of proteins
A6E92_RS08380	COG2197	response regulator
A6E92_RS08395	COG1131	(ABC) transporter
A6E92_RS08400	COG1132	(ABC) transporter
A6E92_RS08405	COG1132	(ABC) transporter
A6E92_RS08430	COG0058	SHG alpha-glucan phosphorylase activity
A6E92_RS08435	COG0366	Alpha amylase catalytic
A6E92_RS08440	COG0366	Alpha amylase catalytic
A6E92_RS08445	COG3281	Trehalose synthase
A6E92_RS08450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6E92_RS08455	COG1301	dicarboxylic acid transport
A6E92_RS08460	COG3290	protein histidine kinase activity
A6E92_RS08465	COG4565	transcriptional regulatory protein
A6E92_RS08475	COG0205	6-phosphofructokinase activity
A6E92_RS08480	COG0857	belongs to the CobB CobQ family
A6E92_RS08480	COG0280	phosphate acetyltransferase
A6E92_RS08485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6E92_RS08530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6E92_RS08530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6E92_RS08650	COG2188	Transcriptional regulator
A6E92_RS08695	COG5002	protein histidine kinase activity
A6E92_RS08700	COG0745	RESPONSE REGULATOR receiver
A6E92_RS08740	COG0183	Belongs to the thiolase family
A6E92_RS08795	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A6E92_RS08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6E92_RS08825	COG3850	Histidine kinase
A6E92_RS08830	COG2197	response regulator
A6E92_RS08845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6E92_RS08850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6E92_RS08855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6E92_RS08860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6E92_RS08865	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6E92_RS08870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6E92_RS08875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6E92_RS08890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6E92_RS08895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6E92_RS08900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6E92_RS08910	COG2890	protein-(glutamine-N5) methyltransferase activity
A6E92_RS08915	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6E92_RS08920	COG0254	rRNA binding
A6E92_RS08925	COG1316	TRANSCRIPTIONal
A6E92_RS08935	COG0083	homoserine kinase activity
A6E92_RS08940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6E92_RS08945	COG0460	homoserine dehydrogenase
A6E92_RS08950	COG0019	diaminopimelate decarboxylase activity
A6E92_RS08955	COG0018	arginyl-trna synthetase
A6E92_RS08975	COG1136	(ABC) transporter
A6E92_RS08985	COG2197	response regulator
A6E92_RS08995	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A6E92_RS09000	COG1793	dna ligase
A6E92_RS09000	COG3285	dna ligase
A6E92_RS09020	COG2205	protein histidine kinase activity
A6E92_RS09035	COG0768	penicillin binding
A6E92_RS09070	COG1309	transcriptional regulator
A6E92_RS09085	COG0791	NLP P60 protein
A6E92_RS09085	COG3883	PFAM NLP P60 protein
A6E92_RS09135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6E92_RS09145	COG0745	RESPONSE REGULATOR receiver
A6E92_RS09150	COG2205	protein histidine kinase activity
A6E92_RS09160	COG0567	Dehydrogenase, E1 component
A6E92_RS09160	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6E92_RS09195	COG0604	alcohol dehydrogenase
A6E92_RS09200	COG0281	malic enzyme
A6E92_RS09205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E92_RS09210	COG0765	amino acid transport
A6E92_RS09215	COG1126	abc transporter atp-binding protein
A6E92_RS09225	COG4106	trans-aconitate 2-methyltransferase activity
A6E92_RS09295	COG0142	geranyltranstransferase activity
A6E92_RS09300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6E92_RS09305	COG1959	2 iron, 2 sulfur cluster binding
A6E92_RS09370	COG2172	sigma factor antagonist activity
A6E92_RS09385	COG1597	lipid kinase activity
A6E92_RS09400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6E92_RS09405	COG0363	glucosamine-6-phosphate deaminase activity
A6E92_RS09410	COG1472	Belongs to the glycosyl hydrolase 3 family
A6E92_RS09415	COG0395	ABC-type sugar transport system, permease component
A6E92_RS09420	COG1175	transmembrane transport
A6E92_RS09425	COG2182	Extracellular solute-binding protein
A6E92_RS09435	COG1966	Carbon starvation protein
A6E92_RS09495	COG0242	peptide deformylase activity
A6E92_RS09505	COG5662	AntiSigma factor
A6E92_RS09510	COG1595	DNA-templated transcription, initiation
A6E92_RS09520	COG2135	peptidase activity
A6E92_RS09530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6E92_RS09535	COG1162	GTPase activity
A6E92_RS09540	COG2076	Multidrug Resistance protein
A6E92_RS09545	COG1309	transcriptional regulator
A6E92_RS09550	COG0483	inositol monophosphate 1-phosphatase activity
A6E92_RS09560	COG0753	catalase activity
A6E92_RS09585	COG1615	UPF0182 protein
A6E92_RS09595	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6E92_RS09645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6E92_RS09690	COG0210	DNA helicase
A6E92_RS09750	COG0601	transmembrane transport
A6E92_RS09760	COG0747	negative chemotaxis
A6E92_RS09805	COG2267	carboxylic ester hydrolase activity
A6E92_RS09810	COG1432	Conserved Protein
A6E92_RS09815	COG2095	MarC family integral membrane protein
A6E92_RS09820	COG0613	PHP domain protein
A6E92_RS09835	COG0598	Magnesium transport protein CorA
A6E92_RS09870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6E92_RS09875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6E92_RS09885	COG1595	DNA-templated transcription, initiation
A6E92_RS09900	COG1024	Enoyl-CoA hydratase
A6E92_RS09905	COG0519	Catalyzes the synthesis of GMP from XMP
A6E92_RS09915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6E92_RS09920	COG1611	Belongs to the LOG family
A6E92_RS09925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6E92_RS09955	COG2912	Transglutaminase-like superfamily
A6E92_RS09960	COG2197	response regulator
A6E92_RS09965	COG1132	(ABC) transporter
A6E92_RS09970	COG1132	(ABC) transporter
A6E92_RS09980	COG0515	serine threonine protein kinase
A6E92_RS09985	COG0110	maltose O-acetyltransferase activity
A6E92_RS10020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6E92_RS10035	COG4608	Belongs to the ABC transporter superfamily
A6E92_RS10045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E92_RS10050	COG0601	transmembrane transport
A6E92_RS10055	COG4166	transmembrane transport
A6E92_RS10060	COG4608	Belongs to the ABC transporter superfamily
A6E92_RS10070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E92_RS10075	COG0601	transmembrane transport
A6E92_RS10080	COG0747	negative chemotaxis
A6E92_RS10090	COG1217	gtp-binding protein TYPA
A6E92_RS10105	COG2226	methyltransferase
A6E92_RS10110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6E92_RS10115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6E92_RS10145	COG0148	phosphopyruvate hydratase activity
A6E92_RS10180	COG3795	YCII-related domain
A6E92_RS10185	COG4941	Belongs to the sigma-70 factor family
A6E92_RS10195	COG0463	Glycosyl transferase, family 2
A6E92_RS10205	COG1842	Phage shock protein A
A6E92_RS10245	COG0789	Transcriptional regulator
A6E92_RS10270	COG4115	mRNA cleavage
A6E92_RS10275	COG2161	toxin-antitoxin pair type II binding
A6E92_RS10280	COG0012	GTP binding
A6E92_RS10295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6E92_RS10305	COG1570	exodeoxyribonuclease VII activity
A6E92_RS10310	COG1722	exodeoxyribonuclease VII activity
A6E92_RS10315	COG0778	Nitroreductase
A6E92_RS10340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A6E92_RS10340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A6E92_RS10345	COG1362	aminopeptidase activity
A6E92_RS10355	COG0114	fumarate hydratase activity
A6E92_RS10370	COG4499	WXG100 protein secretion system (Wss), protein YukC
A6E92_RS10370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6E92_RS10390	COG1136	(ABC) transporter
A6E92_RS10405	COG0450	alkyl hydroperoxide reductase
A6E92_RS10410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6E92_RS10415	COG2826	transposase and inactivated derivatives, IS30 family
A6E92_RS10430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6E92_RS10435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6E92_RS10440	COG0667	Aldo Keto reductase
A6E92_RS10485	COG2885	chlorophyll binding
A6E92_RS10505	COG2197	response regulator
A6E92_RS10540	COG2894	cell division
A6E92_RS10565	COG2610	gluconate transmembrane transporter activity
A6E92_RS10570	COG0251	oxidation-reduction process
A6E92_RS10575	COG1414	Transcriptional regulator
A6E92_RS10590	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A6E92_RS10640	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A6E92_RS10670	COG0640	Transcriptional regulator
A6E92_RS10680	COG2072	flavoprotein involved in K transport
A6E92_RS10685	COG0798	PFAM Bile acid sodium symporter
A6E92_RS10695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6E92_RS10700	COG0492	ferredoxin-NADP+ reductase activity
A6E92_RS10715	COG1331	Highly conserved protein containing a thioredoxin domain
A6E92_RS10745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6E92_RS10755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6E92_RS10770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6E92_RS10780	COG1366	Belongs to the anti-sigma-factor antagonist family
A6E92_RS10785	COG1366	Belongs to the anti-sigma-factor antagonist family
A6E92_RS10790	COG2172	sigma factor antagonist activity
A6E92_RS10800	COG2202	Pas domain
A6E92_RS10800	COG2205	protein histidine kinase activity
A6E92_RS10805	COG0745	RESPONSE REGULATOR receiver
A6E92_RS10830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E92_RS10845	COG1396	sequence-specific DNA binding
A6E92_RS10850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6E92_RS10870	COG1376	ErfK ybiS ycfS ynhG family protein
A6E92_RS10895	COG1024	Enoyl-CoA hydratase
A6E92_RS10910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6E92_RS10920	COG0424	maF-like protein
A6E92_RS10930	COG4770	biotin carboxylase activity
A6E92_RS10940	COG1349	DNA-binding transcription factor activity
A6E92_RS10960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6E92_RS10975	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS10980	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS11010	COG1595	DNA-templated transcription, initiation
A6E92_RS11015	COG0745	RESPONSE REGULATOR receiver
A6E92_RS11020	COG2205	protein histidine kinase activity
A6E92_RS11045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6E92_RS11070	COG0583	DNA-binding transcription factor activity
A6E92_RS11075	COG2814	Major facilitator Superfamily
A6E92_RS11095	COG1404	Belongs to the peptidase S8 family
A6E92_RS11110	COG1079	Belongs to the binding-protein-dependent transport system permease family
A6E92_RS11115	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6E92_RS11120	COG3845	ABC transporter
A6E92_RS11125	COG1744	ABC transporter substrate-binding protein PnrA-like
A6E92_RS11130	COG1473	amidohydrolase
A6E92_RS11130	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A6E92_RS11140	COG2089	acid synthase
A6E92_RS11145	COG1083	cytidylyl-transferase
A6E92_RS11155	COG1216	Glycosyl transferase, family 2
A6E92_RS11165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6E92_RS11190	COG1595	DNA-templated transcription, initiation
A6E92_RS11195	COG0464	growth
A6E92_RS11250	COG2009	succinate dehydrogenase
A6E92_RS11265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6E92_RS11295	COG1408	metallophosphoesterase
A6E92_RS11305	COG1686	Belongs to the peptidase S11 family
A6E92_RS11310	COG1295	ribonuclease BN
A6E92_RS11330	COG0180	Tryptophanyl-tRNA synthetase
A6E92_RS11335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6E92_RS11340	COG0754	glutathionylspermidine amidase activity
A6E92_RS11350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6E92_RS11355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6E92_RS11360	COG0039	L-malate dehydrogenase activity
A6E92_RS11375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6E92_RS11390	COG0138	bifunctional purine biosynthesis protein purh
A6E92_RS11420	COG0045	succinate-CoA ligase (ADP-forming) activity
A6E92_RS11425	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A6E92_RS11430	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A6E92_RS11435	COG0714	Associated with various cellular activities
A6E92_RS11455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6E92_RS11455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6E92_RS11490	COG2197	response regulator
A6E92_RS11530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6E92_RS11530	COG0519	Catalyzes the synthesis of GMP from XMP
A6E92_RS11550	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS11555	COG0515	serine threonine protein kinase
A6E92_RS11570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6E92_RS11585	COG0516	GMP reductase activity
A6E92_RS11600	COG1595	DNA-templated transcription, initiation
A6E92_RS11605	COG2197	response regulator
A6E92_RS11615	COG0583	DNA-binding transcription factor activity
A6E92_RS11625	COG4221	oxidoreductase activity
A6E92_RS11635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6E92_RS11640	COG0726	polysaccharide deacetylase
A6E92_RS11670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6E92_RS11695	COG0802	atpase or kinase
A6E92_RS11705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6E92_RS11710	COG3189	MarR family transcriptional regulator
A6E92_RS11720	COG0736	holo-[acyl-carrier-protein] synthase activity
A6E92_RS11725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6E92_RS11740	COG4941	Belongs to the sigma-70 factor family
A6E92_RS11745	COG3795	YCII-related domain
A6E92_RS11770	COG1072	(Pantothenic acid kinase))
A6E92_RS11780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6E92_RS11785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6E92_RS11790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6E92_RS11795	COG0488	(ABC) transporter
A6E92_RS11805	COG0101	tRNA pseudouridine synthase activity
A6E92_RS11810	COG0203	ribosomal protein L17
A6E92_RS11815	COG0202	RNA polymerase activity
A6E92_RS11820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6E92_RS11825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6E92_RS11830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6E92_RS11835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6E92_RS11845	COG0563	adenylate kinase activity
A6E92_RS11855	COG0200	Binds to the 23S rRNA
A6E92_RS11860	COG1841	ribosomal large subunit assembly
A6E92_RS11865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6E92_RS11870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6E92_RS11875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6E92_RS11880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6E92_RS11890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6E92_RS11895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6E92_RS11900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6E92_RS11905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6E92_RS11910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6E92_RS11915	COG0255	Belongs to the universal ribosomal protein uL29 family
A6E92_RS11920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6E92_RS11925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6E92_RS11930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6E92_RS11935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6E92_RS11940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6E92_RS11945	COG0089	rRNA binding
A6E92_RS11950	COG0088	Forms part of the polypeptide exit tunnel
A6E92_RS11955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6E92_RS11960	COG0051	transcription antitermination factor activity, RNA binding
A6E92_RS11980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6E92_RS11985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6E92_RS11990	COG0049	tRNA binding
A6E92_RS11995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6E92_RS12100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6E92_RS12105	COG0085	RNA polymerase activity
A6E92_RS12115	COG0222	ribosome binding
A6E92_RS12120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6E92_RS12125	COG0081	regulation of translation
A6E92_RS12130	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6E92_RS12150	COG0436	Aminotransferase
A6E92_RS12155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6E92_RS12170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6E92_RS12180	COG2030	dehydratase
A6E92_RS12185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6E92_RS12310	COG1666	GTP binding
A6E92_RS12315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6E92_RS12325	COG2261	transglycosylase associated protein
A6E92_RS12330	COG3304	Inner membrane component domain
A6E92_RS12335	COG0501	Belongs to the peptidase M48B family
A6E92_RS12340	COG1970	mechanosensitive ion channel activity
A6E92_RS12345	COG1007	ATP synthesis coupled electron transport
A6E92_RS12355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6E92_RS12360	COG0713	ATP synthesis coupled electron transport
A6E92_RS12365	COG0839	Belongs to the complex I subunit 6 family
A6E92_RS12370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6E92_RS12375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6E92_RS12380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6E92_RS12385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6E92_RS12390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6E92_RS12410	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6E92_RS12410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6E92_RS12415	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6E92_RS12420	COG1733	regulation of RNA biosynthetic process
A6E92_RS12425	COG0702	epimerase
A6E92_RS12465	COG2160	L-arabinose isomerase activity
A6E92_RS12480	COG4213	ABC transporter substrate-binding protein
A6E92_RS12485	COG1129	ABC transporter
A6E92_RS12490	COG4214	carbohydrate transport
A6E92_RS12495	COG0561	phosphatase activity
A6E92_RS12515	COG1131	(ABC) transporter
A6E92_RS12525	COG0142	geranyltranstransferase activity
A6E92_RS12530	COG3104	oligopeptide transport
A6E92_RS12560	COG1007	ATP synthesis coupled electron transport
A6E92_RS12570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6E92_RS12575	COG0713	ATP synthesis coupled electron transport
A6E92_RS12580	COG0839	Belongs to the complex I subunit 6 family
A6E92_RS12585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6E92_RS12590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6E92_RS12595	COG1034	ATP synthesis coupled electron transport
A6E92_RS12600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6E92_RS12610	COG0649	NAD binding
A6E92_RS12615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6E92_RS12620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6E92_RS12685	COG2226	methyltransferase
A6E92_RS12690	COG2175	clavaminate synthase activity
A6E92_RS12700	COG4521	taurine ABC transporter
A6E92_RS12705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6E92_RS12715	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6E92_RS12725	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A6E92_RS12730	COG1278	Cold shock
A6E92_RS12765	COG1024	Enoyl-CoA hydratase
A6E92_RS12790	COG1309	transcriptional regulator
A6E92_RS12800	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS12820	COG0259	pyridoxamine-phosphate oxidase activity
A6E92_RS12825	COG0501	Belongs to the peptidase M48B family
A6E92_RS12850	COG2072	flavoprotein involved in K transport
A6E92_RS12865	COG0702	epimerase
A6E92_RS12875	COG1024	Enoyl-CoA hydratase
A6E92_RS12925	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS12930	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS12945	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS12950	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS12960	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS13025	COG1595	DNA-templated transcription, initiation
A6E92_RS13040	COG0151	Belongs to the GarS family
A6E92_RS13055	COG2264	protein methyltransferase activity
A6E92_RS13070	COG0477	Major facilitator Superfamily
A6E92_RS13105	COG2267	carboxylic ester hydrolase activity
A6E92_RS13115	COG4821	SIS domain
A6E92_RS13125	COG0259	pyridoxamine-phosphate oxidase activity
A6E92_RS13145	COG2124	cytochrome p450
A6E92_RS13160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6E92_RS13180	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6E92_RS13200	COG1024	Enoyl-CoA hydratase
A6E92_RS13205	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS13220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6E92_RS13240	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
A6E92_RS13245	COG0494	nUDIX hydrolase
A6E92_RS13250	COG5006	permease, DMT superfamily
A6E92_RS13265	COG0247	lactate metabolic process
A6E92_RS13265	COG0277	FAD linked oxidase domain protein
A6E92_RS13270	COG2205	protein histidine kinase activity
A6E92_RS13300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6E92_RS13305	COG2318	DinB family
A6E92_RS13315	COG1302	Protein conserved in bacteria
A6E92_RS13335	COG1335	isochorismatase
A6E92_RS13375	COG1846	Transcriptional regulator
A6E92_RS13380	COG0697	spore germination
A6E92_RS13390	COG1309	transcriptional regulator
A6E92_RS13445	COG0583	DNA-binding transcription factor activity
A6E92_RS13450	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS13455	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS13460	COG0515	serine threonine protein kinase
A6E92_RS13470	COG2267	carboxylic ester hydrolase activity
A6E92_RS13475	COG0667	Aldo Keto reductase
A6E92_RS13500	COG2252	PERMEase
A6E92_RS13510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6E92_RS13530	COG2814	Major facilitator Superfamily
A6E92_RS13540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6E92_RS13545	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A6E92_RS13550	COG1278	Cold shock
A6E92_RS13570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS13575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS13580	COG1120	ATPase activity
A6E92_RS13585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6E92_RS13630	COG4934	collagen metabolic process
A6E92_RS13635	COG0006	proline dipeptidase activity
A6E92_RS13650	COG1061	Type III restriction enzyme res subunit
A6E92_RS13660	COG3973	AAA domain
A6E92_RS13665	COG3142	Participates in the control of copper homeostasis
A6E92_RS13675	COG1984	allophanate hydrolase subunit 2
A6E92_RS13680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6E92_RS13685	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6E92_RS13720	COG1737	Transcriptional regulator
A6E92_RS13725	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6E92_RS13730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E92_RS13730	COG1263	PTS System
A6E92_RS13740	COG2197	response regulator
A6E92_RS13745	COG4251	negative regulation of phosphorylation
A6E92_RS13780	COG1175	transmembrane transport
A6E92_RS13785	COG0395	ABC-type sugar transport system, permease component
A6E92_RS13810	COG1595	DNA-templated transcription, initiation
A6E92_RS13825	COG1132	(ABC) transporter
A6E92_RS13870	COG0463	Glycosyl transferase, family 2
A6E92_RS13875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A6E92_RS13900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6E92_RS13905	COG1105	Belongs to the carbohydrate kinase PfkB family
A6E92_RS13925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6E92_RS13950	COG0666	response to abiotic stimulus
A6E92_RS13960	COG4585	Histidine kinase
A6E92_RS13980	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A6E92_RS13995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E92_RS14015	COG1733	regulation of RNA biosynthetic process
A6E92_RS14020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6E92_RS14030	COG3842	ATPase activity
A6E92_RS14040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6E92_RS14055	COG0215	cysteine-tRNA ligase activity
A6E92_RS14065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6E92_RS14070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6E92_RS14075	COG1329	Transcriptional regulator
A6E92_RS14095	COG5002	protein histidine kinase activity
A6E92_RS14110	COG0588	phosphoglycerate mutase activity
A6E92_RS14145	COG0438	transferase activity, transferring glycosyl groups
A6E92_RS14190	COG2318	DinB family
A6E92_RS14215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6E92_RS14220	COG0736	holo-[acyl-carrier-protein] synthase activity
A6E92_RS14250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6E92_RS14275	COG4770	biotin carboxylase activity
A6E92_RS14305	COG0475	glutathione-regulated potassium exporter activity
A6E92_RS14365	COG4552	Acetyltransferase involved in intracellular survival and related
A6E92_RS14380	COG1490	D-aminoacyl-tRNA deacylase activity
A6E92_RS14390	COG0735	belongs to the Fur family
A6E92_RS14395	COG3485	protocatechuate 3,4-dioxygenase
A6E92_RS14430	COG2897	thiosulfate sulfurtransferase activity
A6E92_RS14455	COG0745	RESPONSE REGULATOR receiver
A6E92_RS14460	COG1609	Transcriptional regulator
A6E92_RS14465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6E92_RS14495	COG0789	Transcriptional regulator
A6E92_RS14520	COG0154	amidase activity
A6E92_RS14535	COG0737	Belongs to the 5'-nucleotidase family
A6E92_RS14550	COG0456	acetyltransferase
A6E92_RS14560	COG1725	Transcriptional regulator
A6E92_RS14565	COG1116	anion transmembrane transporter activity
A6E92_RS14585	COG0406	alpha-ribazole phosphatase activity
A6E92_RS14585	COG0494	nUDIX hydrolase
A6E92_RS14590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6E92_RS14610	COG0306	phosphate transporter
A6E92_RS14620	COG1937	Protein conserved in bacteria
A6E92_RS14635	COG0671	phosphoesterase, PA-phosphatase related
A6E92_RS14640	COG0741	lytic transglycosylase activity
A6E92_RS14640	COG0739	heme binding
A6E92_RS14640	COG1196	nuclear chromosome segregation
A6E92_RS14715	COG1846	Transcriptional regulator
A6E92_RS14730	COG1252	NADH dehydrogenase
A6E92_RS14760	COG0579	oxidoreductase
A6E92_RS14765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6E92_RS14775	COG0739	heme binding
A6E92_RS14775	COG0741	lytic transglycosylase activity
A6E92_RS14775	COG1196	nuclear chromosome segregation
A6E92_RS14785	COG0789	Transcriptional regulator
A6E92_RS14800	COG1191	sigma factor activity
A6E92_RS14810	COG0596	Alpha beta hydrolase
A6E92_RS14820	COG1366	Belongs to the anti-sigma-factor antagonist family
A6E92_RS14835	COG0513	Belongs to the DEAD box helicase family
A6E92_RS14845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6E92_RS14850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6E92_RS14880	COG0785	Cytochrome C biogenesis protein
A6E92_RS14885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6E92_RS14885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6E92_RS14895	COG1643	Atp-dependent helicase
A6E92_RS14930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6E92_RS14945	COG2318	DinB family
A6E92_RS14950	COG1196	nuclear chromosome segregation
A6E92_RS14950	COG0739	heme binding
A6E92_RS14950	COG0741	lytic transglycosylase activity
A6E92_RS14960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6E92_RS14965	COG0047	phosphoribosylformylglycinamidine synthase activity
A6E92_RS14970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6E92_RS14990	COG1131	(ABC) transporter
A6E92_RS15005	COG2197	response regulator
A6E92_RS15015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6E92_RS15030	COG0151	Belongs to the GarS family
A6E92_RS15050	COG3634	alkyl hydroperoxide reductase activity
A6E92_RS15070	COG2226	methyltransferase
A6E92_RS15115	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A6E92_RS15150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6E92_RS15195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6E92_RS15275	COG1518	maintenance of DNA repeat elements
A6E92_RS15290	COG1191	sigma factor activity
A6E92_RS15295	COG1191	sigma factor activity
A6E92_RS15320	COG2353	YceI-like domain
A6E92_RS15325	COG3467	pyridoxamine 5'-phosphate
A6E92_RS15340	COG0477	Major facilitator Superfamily
A6E92_RS15355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A6E92_RS15365	COG2205	protein histidine kinase activity
A6E92_RS15370	COG0745	RESPONSE REGULATOR receiver
A6E92_RS15395	COG1595	DNA-templated transcription, initiation
A6E92_RS15415	COG2186	Transcriptional regulator
A6E92_RS15520	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS15525	COG1595	DNA-templated transcription, initiation
A6E92_RS15550	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS15575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6E92_RS15590	COG0653	protein targeting
A6E92_RS15610	COG0006	proline dipeptidase activity
A6E92_RS15630	COG1999	signal sequence binding
A6E92_RS15640	COG2372	response to copper ion
A6E92_RS15645	COG2837	iron assimilation
A6E92_RS15650	COG0077	Prephenate dehydratase
A6E92_RS15655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6E92_RS15660	COG0561	phosphatase activity
A6E92_RS15685	COG1131	(ABC) transporter
A6E92_RS15700	COG0789	Transcriptional regulator
A6E92_RS15705	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A6E92_RS15715	COG0561	phosphatase activity
A6E92_RS15725	COG4988	ABC transporter
A6E92_RS15730	COG1294	oxidase, subunit
A6E92_RS15735	COG1271	oxidase subunit
A6E92_RS15740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6E92_RS15745	COG1609	Transcriptional regulator
A6E92_RS15750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6E92_RS15760	COG3152	Membrane
A6E92_RS15765	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6E92_RS15790	COG0662	Cupin 2, conserved barrel domain protein
A6E92_RS15795	COG1950	PFAM Membrane protein of
A6E92_RS15800	COG0626	cystathionine gamma-synthase activity
A6E92_RS15820	COG2814	Major facilitator Superfamily
A6E92_RS15850	COG0305	Participates in initiation and elongation during chromosome replication
A6E92_RS15865	COG0359	binds to the 23S rRNA
A6E92_RS15870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6E92_RS15875	COG0629	single-stranded DNA binding
A6E92_RS15880	COG0360	Binds together with S18 to 16S ribosomal RNA
A6E92_RS15905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6E92_RS15925	COG0617	tRNA 3'-terminal CCA addition
A6E92_RS15940	COG0515	serine threonine protein kinase
A6E92_RS15940	COG2815	serine threonine protein kinase
A6E92_RS15945	COG1595	DNA-templated transcription, initiation
A6E92_RS15955	COG0492	ferredoxin-NADP+ reductase activity
A6E92_RS15960	COG3118	belongs to the thioredoxin family
A6E92_RS15975	COG1192	Involved in chromosome partitioning
A6E92_RS15980	COG0357	Ribosomal RNA small subunit methyltransferase G
A6E92_RS15990	COG0706	membrane insertase activity
A6E92_RS15995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6E92_RS16000	COG0594	ribonuclease P activity
A6E92_RS16020	COG0592	DNA-directed DNA polymerase activity
A6E92_RS16025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A6E92_RS16030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6E92_RS16035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A6E92_RS16045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6E92_RS16060	COG0582	viral genome integration into host DNA
A6E92_RS16100	COG0515	serine threonine protein kinase
A6E92_RS16130	COG0705	Rhomboid family
A6E92_RS16145	COG3764	Sortase (surface protein transpeptidase)
A6E92_RS16160	COG3764	Sortase (surface protein transpeptidase)
A6E92_RS16165	COG3764	Sortase (surface protein transpeptidase)
A6E92_RS16170	COG0515	serine threonine protein kinase
A6E92_RS16190	COG1716	ATPase activity
A6E92_RS16195	COG1716	ATPase activity
A6E92_RS16220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E92_RS16225	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS16230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6E92_RS16235	COG2151	metal-sulfur cluster biosynthetic enzyme
A6E92_RS16240	COG3396	Phenylacetate-CoA oxygenase
A6E92_RS16245	COG3460	Phenylacetate-CoA oxygenase
A6E92_RS16250	COG3396	Phenylacetate-CoA oxygenase
A6E92_RS16275	COG1309	transcriptional regulator
A6E92_RS16280	COG1522	sequence-specific DNA binding
A6E92_RS16300	COG0746	molybdenum cofactor guanylyltransferase activity
A6E92_RS16315	COG3321	synthase
A6E92_RS16315	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS16315	COG0604	alcohol dehydrogenase
A6E92_RS16330	COG1136	(ABC) transporter
A6E92_RS16330	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6E92_RS16350	COG0515	serine threonine protein kinase
A6E92_RS16355	COG0515	serine threonine protein kinase
A6E92_RS16380	COG0022	dehydrogenase e1 component
A6E92_RS16385	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6E92_RS16410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6E92_RS16430	COG1362	aminopeptidase activity
A6E92_RS16435	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS16445	COG1741	Belongs to the pirin family
A6E92_RS16460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6E92_RS16470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6E92_RS16475	COG0745	RESPONSE REGULATOR receiver
A6E92_RS16480	COG2205	protein histidine kinase activity
A6E92_RS16485	COG2304	oxidoreductase activity
A6E92_RS16515	COG0431	NADPH-dependent FMN reductase
A6E92_RS16530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A6E92_RS16530	COG1672	PFAM Archaeal ATPase
A6E92_RS16545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6E92_RS16555	COG0180	Tryptophanyl-tRNA synthetase
A6E92_RS16565	COG2255	four-way junction helicase activity
A6E92_RS16590	COG0475	glutathione-regulated potassium exporter activity
A6E92_RS16595	COG0490	domain, Protein
A6E92_RS16630	COG2268	Band 7 protein
A6E92_RS16655	COG0454	-acetyltransferase
A6E92_RS16695	COG1278	Cold shock
A6E92_RS16700	COG0513	Belongs to the DEAD box helicase family
A6E92_RS16705	COG2409	Drug exporters of the RND superfamily
A6E92_RS16710	COG0475	glutathione-regulated potassium exporter activity
A6E92_RS16745	COG3585	molybdate ion transport
A6E92_RS16760	COG1024	Enoyl-CoA hydratase
A6E92_RS16765	COG2124	cytochrome p450
A6E92_RS16770	COG2124	cytochrome p450
A6E92_RS16795	COG1609	Transcriptional regulator
A6E92_RS16805	COG0667	Aldo Keto reductase
A6E92_RS16815	COG1695	Transcriptional regulator
A6E92_RS16830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6E92_RS16845	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS16855	COG0519	Catalyzes the synthesis of GMP from XMP
A6E92_RS16855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6E92_RS16865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6E92_RS16870	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6E92_RS16880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6E92_RS16890	COG0745	RESPONSE REGULATOR receiver
A6E92_RS16905	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS16935	COG1902	pentaerythritol trinitrate reductase activity
A6E92_RS16950	COG0367	asparagine synthase
A6E92_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS17005	COG2130	NADP-dependent
A6E92_RS17015	COG1533	DNA photolyase activity
A6E92_RS17020	COG3046	protein related to deoxyribodipyrimidine photolyase
A6E92_RS17025	COG1376	ErfK ybiS ycfS ynhG family protein
A6E92_RS17040	COG0745	RESPONSE REGULATOR receiver
A6E92_RS17045	COG2205	protein histidine kinase activity
A6E92_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS17070	COG1309	transcriptional regulator
A6E92_RS17110	COG1192	Involved in chromosome partitioning
A6E92_RS17125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6E92_RS17160	COG0717	Belongs to the dCTP deaminase family
A6E92_RS17175	COG2181	nitrate reductase activity
A6E92_RS17175	COG0247	lactate metabolic process
A6E92_RS17185	COG0443	Heat shock 70 kDa protein
A6E92_RS17190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6E92_RS17195	COG0484	heat shock protein binding
A6E92_RS17200	COG0789	Transcriptional regulator
A6E92_RS17230	COG0542	response to heat
A6E92_RS17255	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6E92_RS17270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6E92_RS17275	COG0191	fructose-bisphosphate aldolase activity
A6E92_RS17280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6E92_RS17285	COG0477	Major facilitator Superfamily
A6E92_RS17300	COG3844	kynureninase activity
A6E92_RS17320	COG2197	response regulator
A6E92_RS17325	COG2124	cytochrome p450
A6E92_RS17345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6E92_RS17350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6E92_RS17360	COG0590	tRNA wobble adenosine to inosine editing
A6E92_RS17415	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS17420	COG0662	Cupin 2, conserved barrel domain protein
A6E92_RS17430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS17455	COG0667	Aldo Keto reductase
A6E92_RS17465	COG0592	DNA-directed DNA polymerase activity
A6E92_RS17480	COG3226	Transcriptional regulator
A6E92_RS17485	COG0738	Major facilitator superfamily
A6E92_RS17500	COG0693	protein deglycase activity
A6E92_RS17510	COG1802	Transcriptional regulator
A6E92_RS17525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6E92_RS17530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6E92_RS17540	COG0702	epimerase
A6E92_RS17565	COG1595	DNA-templated transcription, initiation
A6E92_RS17585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6E92_RS17595	COG2755	lipolytic protein G-D-S-L family
A6E92_RS17600	COG0659	secondary active sulfate transmembrane transporter activity
A6E92_RS17605	COG0789	Transcriptional regulator
A6E92_RS17615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E92_RS17615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6E92_RS17630	COG1937	Protein conserved in bacteria
A6E92_RS17645	COG1408	metallophosphoesterase
A6E92_RS17650	COG1610	YqeY-like protein
A6E92_RS17655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6E92_RS17670	COG0003	Pfam Anion-transporting ATPase
A6E92_RS17690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6E92_RS17720	COG2267	carboxylic ester hydrolase activity
A6E92_RS17730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6E92_RS17735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6E92_RS17805	COG1111	helicase
A6E92_RS17805	COG1205	dead DEAH box helicase
A6E92_RS17810	COG1366	Belongs to the anti-sigma-factor antagonist family
A6E92_RS17820	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A6E92_RS17830	COG2890	protein-(glutamine-N5) methyltransferase activity
A6E92_RS17845	COG1754	DNA topoisomerase type I activity
A6E92_RS17845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6E92_RS17850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6E92_RS17970	COG4585	Histidine kinase
A6E92_RS17975	COG2197	response regulator
A6E92_RS18005	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6E92_RS18025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6E92_RS18025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6E92_RS18060	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS18080	COG0076	glutamate decarboxylase activity
A6E92_RS18085	COG0655	NAD(P)H dehydrogenase (quinone) activity
A6E92_RS18095	COG0393	Putative heavy-metal-binding
A6E92_RS18100	COG0586	Pfam SNARE associated Golgi protein
A6E92_RS18110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6E92_RS18115	COG2027	D-alanyl-D-alanine carboxypeptidase
A6E92_RS18125	COG0037	tRNA processing
A6E92_RS18140	COG0302	gtp cyclohydrolase
A6E92_RS18155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6E92_RS18175	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6E92_RS18175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6E92_RS18185	COG0517	IMP dehydrogenase activity
A6E92_RS18185	COG1125	glycine betaine transport
A6E92_RS18190	COG1174	glycine betaine transport
A6E92_RS18210	COG0649	NAD binding
A6E92_RS18225	COG2197	response regulator
A6E92_RS18250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6E92_RS18255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6E92_RS18265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6E92_RS18285	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6E92_RS18310	COG0739	heme binding
A6E92_RS18315	COG2205	protein histidine kinase activity
A6E92_RS18320	COG0745	RESPONSE REGULATOR receiver
A6E92_RS18330	COG1595	DNA-templated transcription, initiation
A6E92_RS18335	COG1194	a g-specific adenine glycosylase
A6E92_RS18345	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A6E92_RS18365	COG0248	Ppx GppA phosphatase
A6E92_RS18370	COG1082	Xylose isomerase domain protein TIM barrel
A6E92_RS18380	COG0129	dihydroxy-acid dehydratase activity
A6E92_RS18390	COG4991	sh3 domain protein
A6E92_RS18400	COG1129	ABC transporter
A6E92_RS18400	COG0842	Transport permease protein
A6E92_RS18410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6E92_RS18435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6E92_RS18440	COG2223	nitrite transmembrane transporter activity
A6E92_RS18495	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A6E92_RS18500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6E92_RS18505	COG0181	hydroxymethylbilane synthase activity
A6E92_RS18510	COG1648	precorrin-2 dehydrogenase activity
A6E92_RS18510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6E92_RS18515	COG0113	porphobilinogen synthase activity
A6E92_RS18545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6E92_RS18580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6E92_RS18590	COG0018	arginyl-trna synthetase
A6E92_RS18595	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6E92_RS18600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6E92_RS18605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A6E92_RS18605	COG0463	Glycosyl transferase, family 2
A6E92_RS18625	COG1690	Belongs to the RtcB family
A6E92_RS18670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6E92_RS18675	COG0406	alpha-ribazole phosphatase activity
A6E92_RS18680	COG2382	esterase
A6E92_RS18695	COG0785	Cytochrome C biogenesis protein
A6E92_RS18700	COG1333	cytochrome c biogenesis protein
A6E92_RS18705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6E92_RS18715	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6E92_RS18730	COG0163	prenyltransferase activity
A6E92_RS18740	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6E92_RS18755	COG1301	dicarboxylic acid transport
A6E92_RS18770	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS18800	COG1309	transcriptional regulator
A6E92_RS18815	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS18830	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
A6E92_RS18910	COG0454	-acetyltransferase
A6E92_RS18930	COG0667	Aldo Keto reductase
A6E92_RS18950	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A6E92_RS18965	COG2375	cellular response to nickel ion
A6E92_RS18965	COG1132	(ABC) transporter
A6E92_RS18985	COG0768	penicillin binding
A6E92_RS18995	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6E92_RS19025	COG3655	Transcriptional regulator
A6E92_RS19080	COG1686	Belongs to the peptidase S11 family
A6E92_RS19115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6E92_RS19150	COG3903	Transcriptional regulator
A6E92_RS19150	COG3629	intracellular signal transduction
A6E92_RS19185	COG0463	Glycosyl transferase, family 2
A6E92_RS19210	COG0475	glutathione-regulated potassium exporter activity
A6E92_RS19215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6E92_RS19240	COG2197	response regulator
A6E92_RS19270	COG1846	Transcriptional regulator
A6E92_RS19275	COG3384	dioxygenase
A6E92_RS19295	COG0477	Major facilitator Superfamily
A6E92_RS19315	COG0243	molybdopterin cofactor binding
A6E92_RS19320	COG0437	4 iron, 4 sulfur cluster binding
A6E92_RS19340	COG1970	mechanosensitive ion channel activity
A6E92_RS19350	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6E92_RS19365	COG3263	regulation of cellular component size
A6E92_RS19375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6E92_RS19380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6E92_RS19390	COG0315	cyclic pyranopterin monophosphate synthase activity
A6E92_RS19395	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6E92_RS19400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6E92_RS19425	COG2340	Cysteine-rich secretory protein family
A6E92_RS19435	COG0708	Exodeoxyribonuclease III
A6E92_RS19445	COG2072	flavoprotein involved in K transport
A6E92_RS19455	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS19470	COG0793	Belongs to the peptidase S41A family
A6E92_RS19470	COG4946	Tricorn protease homolog
A6E92_RS19480	COG2409	Drug exporters of the RND superfamily
A6E92_RS19490	COG0310	cobalt ion transport
A6E92_RS19500	COG1122	ATPase activity
A6E92_RS19505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6E92_RS19545	COG1115	amino acid carrier protein
A6E92_RS19555	COG0442	prolyl-tRNA aminoacylation
A6E92_RS19615	COG0084	hydrolase, TatD family'
A6E92_RS19625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6E92_RS19630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6E92_RS19635	COG2318	DinB family
A6E92_RS19640	COG2813	Specifically methylates the guanine in position
A6E92_RS19660	COG0488	(ABC) transporter
A6E92_RS19685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E92_RS19700	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6E92_RS19710	COG2197	response regulator
A6E92_RS19720	COG4106	trans-aconitate 2-methyltransferase activity
A6E92_RS19740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6E92_RS19750	COG0193	aminoacyl-tRNA hydrolase activity
A6E92_RS19755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6E92_RS19760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6E92_RS19765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6E92_RS19780	COG4585	Histidine kinase
A6E92_RS19820	COG1607	acyl-coa hydrolase
A6E92_RS19835	COG1917	Cupin 2, conserved barrel domain protein
A6E92_RS19855	COG0346	lactoylglutathione lyase activity
A6E92_RS19860	COG0640	Transcriptional regulator
A6E92_RS19865	COG2124	cytochrome p450
A6E92_RS19895	COG2814	Major facilitator Superfamily
A6E92_RS19900	COG1136	(ABC) transporter
A6E92_RS19905	COG0577	efflux transmembrane transporter activity
A6E92_RS19915	COG3903	Transcriptional regulator
A6E92_RS19915	COG3629	intracellular signal transduction
A6E92_RS19945	COG1994	Peptidase M50
A6E92_RS20035	COG2124	cytochrome p450
A6E92_RS20055	COG0148	phosphopyruvate hydratase activity
A6E92_RS20080	COG1252	NADH dehydrogenase
A6E92_RS20085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6E92_RS20090	COG0577	efflux transmembrane transporter activity
A6E92_RS20090	COG1136	(ABC) transporter
A6E92_RS20095	COG0577	efflux transmembrane transporter activity
A6E92_RS20095	COG1136	(ABC) transporter
A6E92_RS20120	COG0183	Belongs to the thiolase family
A6E92_RS20125	COG2755	lipolytic protein G-D-S-L family
A6E92_RS20170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A6E92_RS20175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6E92_RS20185	COG1228	amidohydrolase
A6E92_RS20190	COG1191	sigma factor activity
A6E92_RS20195	COG1366	Belongs to the anti-sigma-factor antagonist family
A6E92_RS20225	COG3104	oligopeptide transport
A6E92_RS20230	COG0745	RESPONSE REGULATOR receiver
A6E92_RS20235	COG2205	protein histidine kinase activity
A6E92_RS20275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6E92_RS20315	COG1316	TRANSCRIPTIONal
A6E92_RS20325	COG1316	TRANSCRIPTIONal
A6E92_RS20335	COG1316	TRANSCRIPTIONal
A6E92_RS20340	COG1316	TRANSCRIPTIONal
A6E92_RS20355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6E92_RS20365	COG0778	Nitroreductase
A6E92_RS20365	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A6E92_RS20370	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6E92_RS20410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6E92_RS20415	COG2835	tetraacyldisaccharide 4'-kinase activity
A6E92_RS20425	COG1482	cell wall glycoprotein biosynthetic process
A6E92_RS20435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6E92_RS20475	COG0714	Associated with various cellular activities
A6E92_RS20495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A6E92_RS20500	COG0745	RESPONSE REGULATOR receiver
A6E92_RS20505	COG5000	phosphorelay sensor kinase activity
A6E92_RS20505	COG5002	protein histidine kinase activity
A6E92_RS20510	COG0823	Involved in the tonB-independent uptake of proteins
A6E92_RS20520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6E92_RS20525	COG2197	response regulator
A6E92_RS20540	COG0653	protein targeting
A6E92_RS20565	COG2902	Dehydrogenase
A6E92_RS20580	COG1309	transcriptional regulator
A6E92_RS20590	COG0395	ABC-type sugar transport system, permease component
A6E92_RS20595	COG1175	transmembrane transport
A6E92_RS20610	COG0515	serine threonine protein kinase
A6E92_RS20615	COG0515	serine threonine protein kinase
A6E92_RS20620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6E92_RS20635	COG2884	Cell division ATP-binding protein ftsE
A6E92_RS20640	COG2177	Part of the ABC transporter FtsEX involved in
A6E92_RS20645	COG0793	Belongs to the peptidase S41A family
A6E92_RS20650	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6E92_RS20695	COG0583	DNA-binding transcription factor activity
A6E92_RS20725	COG3973	AAA domain
A6E92_RS20735	COG0776	regulation of translation
A6E92_RS20740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6E92_RS20745	COG1678	Uncharacterized ACR, COG1678
A6E92_RS20765	COG0395	ABC-type sugar transport system, permease component
A6E92_RS20770	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6E92_RS20815	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6E92_RS20820	COG1732	Glycine betaine
A6E92_RS20825	COG1174	glycine betaine transport
A6E92_RS20835	COG1174	glycine betaine transport
A6E92_RS20845	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A6E92_RS20855	COG0277	FAD linked oxidase domain protein
A6E92_RS20890	COG1335	isochorismatase
A6E92_RS20900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6E92_RS20910	COG1113	amino acid transport
A6E92_RS20925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS20950	COG1234	tRNA 3'-trailer cleavage
A6E92_RS20955	COG1263	PTS System
A6E92_RS20960	COG1263	PTS System
A6E92_RS20965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E92_RS20970	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6E92_RS20980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6E92_RS20995	COG0477	Major facilitator Superfamily
A6E92_RS21020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6E92_RS21035	COG4555	ABC transporter
A6E92_RS21050	COG2733	membrane
A6E92_RS21055	COG2313	pseudouridylate synthase activity
A6E92_RS21065	COG0546	phosphoglycolate phosphatase activity
A6E92_RS21070	COG0697	spore germination
A6E92_RS21100	COG0789	Transcriptional regulator
A6E92_RS21135	COG1074	ATP-dependent DNA helicase activity
A6E92_RS21165	COG0270	DNA (cytosine-5-)-methyltransferase activity
A6E92_RS21195	COG3764	Sortase (surface protein transpeptidase)
A6E92_RS21215	COG4702	Belongs to the UPF0303 family
A6E92_RS21220	COG0673	inositol 2-dehydrogenase activity
A6E92_RS21240	COG2188	Transcriptional regulator
A6E92_RS21245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E92_RS21295	COG3397	chitin binding
A6E92_RS21310	COG1126	abc transporter atp-binding protein
A6E92_RS21315	COG0765	amino acid transport
A6E92_RS21320	COG0765	amino acid transport
A6E92_RS21325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E92_RS21340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6E92_RS21395	COG0588	phosphoglycerate mutase activity
A6E92_RS21435	COG2985	domain, Protein
A6E92_RS21440	COG2985	domain, Protein
A6E92_RS21455	COG0395	ABC-type sugar transport system, permease component
A6E92_RS21490	COG4977	sequence-specific DNA binding
A6E92_RS21495	COG0589	response to stress
A6E92_RS21500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6E92_RS21525	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A6E92_RS21530	COG0076	glutamate decarboxylase activity
A6E92_RS21550	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS21565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6E92_RS21570	COG1309	transcriptional regulator
A6E92_RS21585	COG2755	lipolytic protein G-D-S-L family
A6E92_RS21585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6E92_RS21605	COG1946	Acyl-CoA thioesterase
A6E92_RS21610	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS21655	COG3960	tartronate-semialdehyde synthase activity
A6E92_RS21685	COG1472	Belongs to the glycosyl hydrolase 3 family
A6E92_RS21705	COG1404	Belongs to the peptidase S8 family
A6E92_RS21735	COG0515	serine threonine protein kinase
A6E92_RS21760	COG1609	Transcriptional regulator
A6E92_RS21765	COG0673	inositol 2-dehydrogenase activity
A6E92_RS21835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6E92_RS21860	COG2409	Drug exporters of the RND superfamily
A6E92_RS21865	COG3615	Tellurite resistance protein tehB
A6E92_RS21865	COG0500	methyltransferase
A6E92_RS21875	COG2318	DinB family
A6E92_RS21895	COG3718	enzyme involved in inositol metabolism
A6E92_RS21900	COG3962	Belongs to the TPP enzyme family
A6E92_RS21915	COG1131	(ABC) transporter
A6E92_RS21965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6E92_RS21970	COG0629	single-stranded DNA binding
A6E92_RS22000	COG2346	COG2346, Truncated hemoglobins
A6E92_RS22005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6E92_RS22035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E92_RS22050	COG1486	melibiose metabolic process
A6E92_RS22055	COG0395	ABC-type sugar transport system, permease component
A6E92_RS22060	COG1175	transmembrane transport
A6E92_RS22070	COG1940	carbohydrate kinase activity
A6E92_RS22075	COG0668	transmembrane transport
A6E92_RS22085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6E92_RS22085	COG3291	Pkd domain containing protein
A6E92_RS22100	COG0583	DNA-binding transcription factor activity
A6E92_RS22105	COG4266	Belongs to the allantoicase family
A6E92_RS22140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6E92_RS22155	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS22165	COG0110	maltose O-acetyltransferase activity
A6E92_RS22175	COG0640	Transcriptional regulator
A6E92_RS22180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6E92_RS22185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6E92_RS22190	COG0783	Belongs to the Dps family
A6E92_RS22200	COG1113	amino acid transport
A6E92_RS22205	COG1113	amino acid transport
A6E92_RS22210	COG1268	BioY protein
A6E92_RS22215	COG1113	amino acid transport
A6E92_RS22230	COG4552	Acetyltransferase involved in intracellular survival and related
A6E92_RS22240	COG0475	glutathione-regulated potassium exporter activity
A6E92_RS22245	COG3594	Acyltransferase
A6E92_RS22265	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6E92_RS22270	COG0740	serine-type endopeptidase activity
A6E92_RS22275	COG0740	serine-type endopeptidase activity
A6E92_RS22280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6E92_RS22290	COG0525	valine-tRNA ligase activity
A6E92_RS22295	COG0285	dihydrofolate synthase activity
A6E92_RS22305	COG0105	UTP biosynthetic process
A6E92_RS22310	COG1077	Cell shape determining protein MreB Mrl
A6E92_RS22325	COG0768	penicillin binding
A6E92_RS22330	COG0772	Belongs to the SEDS family
A6E92_RS22355	COG1530	ribonuclease E activity
A6E92_RS22360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6E92_RS22400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6E92_RS22405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6E92_RS22410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6E92_RS22430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6E92_RS22440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6E92_RS22455	COG0501	Belongs to the peptidase M48B family
A6E92_RS22460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6E92_RS22470	COG0799	negative regulation of ribosome biogenesis
A6E92_RS22475	COG0588	phosphoglycerate mutase activity
A6E92_RS22510	COG0495	leucyl-tRNA aminoacylation
A6E92_RS22520	COG1307	EDD domain protein, DegV family
A6E92_RS22525	COG1555	photosystem II stabilization
A6E92_RS22680	COG0494	nUDIX hydrolase
A6E92_RS22755	COG2353	YceI-like domain
A6E92_RS22770	COG0268	Binds directly to 16S ribosomal RNA
A6E92_RS22775	COG0481	GTPase activity
A6E92_RS22780	COG1022	Amp-dependent synthetase and ligase
A6E92_RS22805	COG1420	regulation of RNA biosynthetic process
A6E92_RS22810	COG0484	heat shock protein binding
A6E92_RS22825	COG0537	adenosine 5'-monophosphoramidase activity
A6E92_RS22830	COG1234	tRNA 3'-trailer cleavage
A6E92_RS22835	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6E92_RS22845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E92_RS22855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6E92_RS22865	COG2315	Protein conserved in bacteria
A6E92_RS22880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6E92_RS22895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6E92_RS22905	COG1381	Involved in DNA repair and RecF pathway recombination
A6E92_RS22910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6E92_RS22920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6E92_RS22925	COG1121	(ABC) transporter
A6E92_RS22935	COG0423	glycine-tRNA ligase activity
A6E92_RS22955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6E92_RS22965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6E92_RS22995	COG2197	response regulator
A6E92_RS23010	COG4221	oxidoreductase activity
A6E92_RS23065	COG2066	Belongs to the glutaminase family
A6E92_RS23125	COG4942	peptidase
A6E92_RS23170	COG2188	Transcriptional regulator
A6E92_RS23185	COG2011	ABC-type metal ion transport system permease component
A6E92_RS23190	COG3842	ATPase activity
A6E92_RS23195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6E92_RS23200	COG0574	Belongs to the PEP-utilizing enzyme family
A6E92_RS23200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6E92_RS23260	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6E92_RS23280	COG2226	methyltransferase
A6E92_RS23285	COG0358	DNA primase activity
A6E92_RS23305	COG1070	Carbohydrate kinase
A6E92_RS23330	COG1914	H( )-stimulated, divalent metal cation uptake system
A6E92_RS23340	COG1942	4-Oxalocrotonate Tautomerase
A6E92_RS23350	COG3971	2-oxopent-4-enoate hydratase activity
A6E92_RS23375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6E92_RS23380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6E92_RS23390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6E92_RS23425	COG0825	malonyl-CoA metabolic process
A6E92_RS23425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6E92_RS23430	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS23440	COG1522	sequence-specific DNA binding
A6E92_RS23470	COG2130	NADP-dependent
A6E92_RS23475	COG1764	response to oxidative stress
A6E92_RS23485	COG1309	transcriptional regulator
A6E92_RS23510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6E92_RS23515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6E92_RS23520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6E92_RS23535	COG1741	Belongs to the pirin family
A6E92_RS23540	COG0367	asparagine synthase
A6E92_RS23580	COG0789	Transcriptional regulator
A6E92_RS23585	COG0667	Aldo Keto reductase
A6E92_RS23600	COG2197	response regulator
A6E92_RS23605	COG4585	Histidine kinase
A6E92_RS23620	COG1309	transcriptional regulator
A6E92_RS23625	COG0477	Major facilitator Superfamily
A6E92_RS23635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6E92_RS23680	COG1358	cellular component organization or biogenesis
A6E92_RS23715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6E92_RS23800	COG2124	cytochrome p450
A6E92_RS23805	COG0183	Belongs to the thiolase family
A6E92_RS23815	COG3845	ABC transporter
A6E92_RS23885	COG1309	transcriptional regulator
A6E92_RS23890	COG0438	transferase activity, transferring glycosyl groups
A6E92_RS23920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6E92_RS23955	COG0655	NAD(P)H dehydrogenase (quinone) activity
A6E92_RS23965	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS23980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS23990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6E92_RS23995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6E92_RS24010	COG3903	Transcriptional regulator
A6E92_RS24010	COG3629	intracellular signal transduction
A6E92_RS24015	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS24020	COG0183	Belongs to the thiolase family
A6E92_RS24025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6E92_RS24035	COG2030	dehydratase
A6E92_RS24055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6E92_RS24060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6E92_RS24080	COG0800	Aldolase
A6E92_RS24085	COG3022	response to hydroperoxide
A6E92_RS24110	COG2273	Hydrolase Family 16
A6E92_RS24135	COG0384	phenazine biosynthesis protein PhzF
A6E92_RS24145	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS24150	COG3540	Alkaline phosphatase
A6E92_RS24160	COG2814	Major facilitator Superfamily
A6E92_RS24175	COG1834	amidinotransferase
A6E92_RS24195	COG1120	ATPase activity
A6E92_RS24200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS24205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6E92_RS24225	COG5398	heme oxygenase
A6E92_RS24265	COG1994	Peptidase M50
A6E92_RS24285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6E92_RS24290	COG0477	Major facilitator Superfamily
A6E92_RS24305	COG2814	Major facilitator Superfamily
A6E92_RS24310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6E92_RS24310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6E92_RS24315	COG2132	Multicopper oxidase
A6E92_RS24330	COG0174	glutamine synthetase
A6E92_RS24395	COG2890	protein-(glutamine-N5) methyltransferase activity
A6E92_RS24400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6E92_RS24415	COG1609	Transcriptional regulator
A6E92_RS24425	COG1175	transmembrane transport
A6E92_RS24430	COG3833	ABC-type maltose transport systems, permease component
A6E92_RS24435	COG0366	Alpha amylase catalytic
A6E92_RS24495	COG0745	RESPONSE REGULATOR receiver
A6E92_RS24530	COG1846	Transcriptional regulator
A6E92_RS24540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6E92_RS24565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6E92_RS24570	COG0321	lipoyl(octanoyl) transferase activity
A6E92_RS24585	COG1090	epimerase
A6E92_RS24605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6E92_RS24615	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6E92_RS24620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6E92_RS24625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6E92_RS24630	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A6E92_RS24650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A6E92_RS24665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6E92_RS24690	COG4585	Histidine kinase
A6E92_RS24695	COG2197	response regulator
A6E92_RS24700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E92_RS24710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6E92_RS24730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E92_RS24735	COG1104	cysteine desulfurase activity
A6E92_RS24740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6E92_RS24745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6E92_RS24755	COG1376	ErfK ybiS ycfS ynhG family protein
A6E92_RS24765	COG1845	cytochrome c oxidase, subunit III
A6E92_RS24770	COG2010	Cytochrome c
A6E92_RS24775	COG0723	plastoquinol--plastocyanin reductase activity
A6E92_RS24780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6E92_RS24785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6E92_RS24790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6E92_RS24855	COG0003	Pfam Anion-transporting ATPase
A6E92_RS24865	COG1940	carbohydrate kinase activity
A6E92_RS24890	COG4585	Histidine kinase
A6E92_RS24895	COG2197	response regulator
A6E92_RS24900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6E92_RS24910	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6E92_RS24920	COG2193	ferroxidase activity
A6E92_RS24925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6E92_RS24930	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6E92_RS24935	COG0515	serine threonine protein kinase
A6E92_RS24935	COG2815	serine threonine protein kinase
A6E92_RS24940	COG2022	thiamine diphosphate biosynthetic process
A6E92_RS24950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E92_RS24950	COG2022	thiamine diphosphate biosynthetic process
A6E92_RS24970	COG0352	thiamine-phosphate diphosphorylase activity
A6E92_RS25000	COG1511	domain protein
A6E92_RS25005	COG1131	(ABC) transporter
A6E92_RS25015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6E92_RS25035	COG0714	Associated with various cellular activities
A6E92_RS25045	COG0275	rRNA processing
A6E92_RS25055	COG0768	penicillin binding
A6E92_RS25060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6E92_RS25070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6E92_RS25075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6E92_RS25085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6E92_RS25110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6E92_RS25115	COG1799	cell septum assembly
A6E92_RS25125	COG3599	regulation of cell shape
A6E92_RS25130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6E92_RS25145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6E92_RS25190	COG0587	DNA-directed DNA polymerase activity
A6E92_RS25200	COG1432	Conserved Protein
A6E92_RS25225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6E92_RS25240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6E92_RS25245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6E92_RS25250	COG0131	Imidazoleglycerol-phosphate dehydratase
A6E92_RS25255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6E92_RS25260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6E92_RS25265	COG0251	oxidation-reduction process
A6E92_RS25270	COG0107	imidazoleglycerol-phosphate synthase activity
A6E92_RS25285	COG2508	Transcriptional regulator
A6E92_RS25295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6E92_RS25300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6E92_RS25320	COG0134	indole-3-glycerol-phosphate synthase activity
A6E92_RS25330	COG0133	tryptophan synthase activity
A6E92_RS25335	COG0159	tryptophan synthase activity
A6E92_RS25345	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6E92_RS25355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6E92_RS25360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E92_RS25390	COG0067	glutamate synthase
A6E92_RS25390	COG0069	glutamate synthase activity
A6E92_RS25390	COG0070	glutamate synthase
A6E92_RS25400	COG0705	Rhomboid family
A6E92_RS25420	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS25425	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS25430	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS25435	COG1309	transcriptional regulator
A6E92_RS25445	COG1278	Cold shock
A6E92_RS25470	COG1024	Enoyl-CoA hydratase
A6E92_RS25475	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS25510	COG0287	Prephenate dehydrogenase
A6E92_RS25510	COG1605	Chorismate mutase
A6E92_RS25515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6E92_RS25530	COG2824	Alkylphosphonate utilization operon protein PhnA
A6E92_RS25540	COG0659	secondary active sulfate transmembrane transporter activity
A6E92_RS25560	COG0737	Belongs to the 5'-nucleotidase family
A6E92_RS25615	COG2050	protein possibly involved in aromatic compounds catabolism
A6E92_RS25645	COG1643	Atp-dependent helicase
A6E92_RS25650	COG2226	methyltransferase
A6E92_RS25670	COG0237	dephospho-CoA kinase activity
A6E92_RS25695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6E92_RS25710	COG0436	Aminotransferase
A6E92_RS25730	COG2313	pseudouridylate synthase activity
A6E92_RS25740	COG2814	Major facilitator Superfamily
A6E92_RS25745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6E92_RS25750	COG0584	glycerophosphoryl diester phosphodiesterase
A6E92_RS25760	COG0556	nucleotide-excision repair
A6E92_RS25790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6E92_RS25815	COG0322	excinuclease ABC activity
A6E92_RS25820	COG1660	Displays ATPase and GTPase activities
A6E92_RS25825	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6E92_RS25830	COG1481	regulation of sporulation
A6E92_RS25835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6E92_RS25840	COG0126	phosphoglycerate kinase activity
A6E92_RS25845	COG0149	triose-phosphate isomerase activity
A6E92_RS25850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6E92_RS25860	COG0166	Belongs to the GPI family
A6E92_RS25875	COG4195	phage-related replication protein
A6E92_RS25880	COG0363	glucosamine-6-phosphate deaminase activity
A6E92_RS25895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6E92_RS25905	COG0109	protoheme IX farnesyltransferase activity
A6E92_RS25915	COG1612	heme a metabolic process
A6E92_RS25925	COG1131	(ABC) transporter
A6E92_RS25940	COG0719	Fe-S assembly protein
A6E92_RS25950	COG0396	ATPase activity
A6E92_RS25955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6E92_RS25960	COG0822	iron-sulfur transferase activity
A6E92_RS25965	COG2151	metal-sulfur cluster biosynthetic enzyme
A6E92_RS25985	COG3226	Transcriptional regulator
A6E92_RS25990	COG2171	N-acyltransferase activity
A6E92_RS25995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6E92_RS26015	COG0583	DNA-binding transcription factor activity
A6E92_RS26030	COG0431	NADPH-dependent FMN reductase
A6E92_RS26040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6E92_RS26045	COG0768	penicillin binding
A6E92_RS26080	COG1131	(ABC) transporter
A6E92_RS26090	COG1595	DNA-templated transcription, initiation
A6E92_RS26100	COG1902	pentaerythritol trinitrate reductase activity
A6E92_RS26130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6E92_RS26155	COG1797	cobyrinic acid a,c-diamide synthase activity
A6E92_RS26170	COG1492	cobalamin metabolic process
A6E92_RS26175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A6E92_RS26190	COG0235	Class ii aldolase
A6E92_RS26215	COG0488	(ABC) transporter
A6E92_RS26225	COG1024	Enoyl-CoA hydratase
A6E92_RS26265	COG3387	PFAM Glycoside hydrolase 15-related
A6E92_RS26280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6E92_RS26305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E92_RS26310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6E92_RS26330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6E92_RS26345	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS26350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6E92_RS26360	COG2186	Transcriptional regulator
A6E92_RS26380	COG3830	Belongs to the UPF0237 family
A6E92_RS26380	COG0560	Phosphoserine phosphatase
A6E92_RS26385	COG1716	ATPase activity
A6E92_RS26385	COG1131	(ABC) transporter
A6E92_RS26385	COG0842	Transport permease protein
A6E92_RS26395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6E92_RS26410	COG2197	response regulator
A6E92_RS26425	COG1119	ATPase activity
A6E92_RS26450	COG1881	PFAM PEBP family protein
A6E92_RS26460	COG2094	Belongs to the DNA glycosylase MPG family
A6E92_RS26490	COG0647	UMP catabolic process
A6E92_RS26495	COG1120	ATPase activity
A6E92_RS26515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6E92_RS26520	COG0497	DNA recombination
A6E92_RS26525	COG0297	glycogen (starch) synthase activity
A6E92_RS26555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E92_RS26565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6E92_RS26585	COG3387	PFAM Glycoside hydrolase 15-related
A6E92_RS26590	COG0504	CTP synthase activity
A6E92_RS26595	COG0494	nUDIX hydrolase
A6E92_RS26605	COG0686	Belongs to the AlaDH PNT family
A6E92_RS26620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6E92_RS26625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6E92_RS26630	COG1187	pseudouridine synthase activity
A6E92_RS26645	COG0494	nUDIX hydrolase
A6E92_RS26685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6E92_RS26695	COG1160	GTP binding
A6E92_RS26710	COG0438	transferase activity, transferring glycosyl groups
A6E92_RS26730	COG0671	phosphoesterase, PA-phosphatase related
A6E92_RS26735	COG0477	Major facilitator Superfamily
A6E92_RS26740	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS26745	COG1799	cell septum assembly
A6E92_RS26755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E92_RS26760	COG0765	amino acid transport
A6E92_RS26780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E92_RS26790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6E92_RS26850	COG0587	DNA-directed DNA polymerase activity
A6E92_RS26855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6E92_RS26880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6E92_RS26885	COG2188	Transcriptional regulator
A6E92_RS26975	COG4565	transcriptional regulatory protein
A6E92_RS26995	COG0346	lactoylglutathione lyase activity
A6E92_RS27010	COG1725	Transcriptional regulator
A6E92_RS27020	COG2755	lipolytic protein G-D-S-L family
A6E92_RS27030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6E92_RS27040	COG2188	Transcriptional regulator
A6E92_RS27045	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6E92_RS27050	COG1309	transcriptional regulator
A6E92_RS27055	COG0243	molybdopterin cofactor binding
A6E92_RS27060	COG2851	Citrate transporter
A6E92_RS27080	COG2326	polyphosphate kinase activity
A6E92_RS27095	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS27135	COG3876	Protein conserved in bacteria
A6E92_RS27145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6E92_RS27155	COG4935	Belongs to the peptidase S8 family
A6E92_RS27155	COG2234	aminopeptidase activity
A6E92_RS27160	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS27180	COG2149	membrane
A6E92_RS27185	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A6E92_RS27190	COG3573	Dehydrogenase
A6E92_RS27220	COG3265	gluconokinase activity
A6E92_RS27225	COG2186	Transcriptional regulator
A6E92_RS27235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6E92_RS27240	COG0564	pseudouridine synthase activity
A6E92_RS27250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6E92_RS27280	COG0667	Aldo Keto reductase
A6E92_RS27285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6E92_RS27295	COG0598	Magnesium transport protein CorA
A6E92_RS27315	COG0215	cysteine-tRNA ligase activity
A6E92_RS27325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6E92_RS27330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6E92_RS27335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6E92_RS27340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6E92_RS27345	COG1414	Transcriptional regulator
A6E92_RS27350	COG0646	methionine synthase
A6E92_RS27350	COG1410	methionine synthase
A6E92_RS27360	COG4166	transmembrane transport
A6E92_RS27365	COG2197	response regulator
A6E92_RS27375	COG0517	IMP dehydrogenase activity
A6E92_RS27375	COG1994	Peptidase M50
A6E92_RS27400	COG1222	aaa ATPase
A6E92_RS27405	COG4122	O-methyltransferase activity
A6E92_RS27420	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A6E92_RS27425	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A6E92_RS27430	COG1609	Transcriptional regulator
A6E92_RS27440	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A6E92_RS27445	COG0545	Peptidyl-prolyl cis-trans isomerase
A6E92_RS27455	COG2378	regulation of single-species biofilm formation
A6E92_RS27475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6E92_RS27480	COG0805	protein transport
A6E92_RS27520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6E92_RS27525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6E92_RS27545	COG1595	DNA-templated transcription, initiation
A6E92_RS27570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6E92_RS27575	COG0517	IMP dehydrogenase activity
A6E92_RS27575	COG4175	Glycine betaine
A6E92_RS27640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6E92_RS27645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6E92_RS27650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6E92_RS27655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6E92_RS27660	COG5002	protein histidine kinase activity
A6E92_RS27665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6E92_RS27670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6E92_RS27670	COG0072	phenylalanine-tRNA ligase activity
A6E92_RS27690	COG1649	PFAM Uncharacterised BCR, COG1649
A6E92_RS27695	COG0697	spore germination
A6E92_RS27710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6E92_RS27755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6E92_RS27760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6E92_RS27765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6E92_RS27770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6E92_RS27775	COG1438	arginine binding
A6E92_RS27785	COG0137	argininosuccinate synthase activity
A6E92_RS27790	COG0165	Argininosuccinate lyase
A6E92_RS27800	COG3973	AAA domain
A6E92_RS27805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6E92_RS27815	COG0477	Major facilitator Superfamily
A6E92_RS27855	COG2011	ABC-type metal ion transport system permease component
A6E92_RS27860	COG1464	Belongs to the NlpA lipoprotein family
A6E92_RS27875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A6E92_RS27880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6E92_RS27880	COG1648	precorrin-2 dehydrogenase activity
A6E92_RS27940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6E92_RS27995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6E92_RS28010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6E92_RS28035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6E92_RS28040	COG1560	Kdo2-lipid A biosynthetic process
A6E92_RS28045	COG0438	transferase activity, transferring glycosyl groups
A6E92_RS28055	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A6E92_RS28060	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A6E92_RS28065	COG0217	transcriptional regulatory protein
A6E92_RS28070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6E92_RS28075	COG0632	four-way junction helicase activity
A6E92_RS28080	COG2255	four-way junction helicase activity
A6E92_RS28090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E92_RS28095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E92_RS28100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6E92_RS28105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6E92_RS28110	COG1196	nuclear chromosome segregation
A6E92_RS28125	COG0124	histidyl-tRNA synthetase
A6E92_RS28145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6E92_RS28165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6E92_RS28170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6E92_RS28185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6E92_RS28190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6E92_RS28195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6E92_RS28200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6E92_RS28210	COG0006	proline dipeptidase activity
A6E92_RS28215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6E92_RS28220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6E92_RS28230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6E92_RS28235	COG0540	Belongs to the ATCase OTCase family
A6E92_RS28240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6E92_RS28250	COG0505	Belongs to the CarA family
A6E92_RS28255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6E92_RS28260	COG0167	dihydroorotate dehydrogenase activity
A6E92_RS28265	COG0284	orotidine-5'-phosphate decarboxylase activity
A6E92_RS28280	COG1758	RNA polymerase activity
A6E92_RS28290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6E92_RS28305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6E92_RS28315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6E92_RS28320	COG2390	Transcriptional regulator
A6E92_RS28335	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS28345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6E92_RS28360	COG2233	PERMEase
A6E92_RS28365	COG0738	Major facilitator superfamily
A6E92_RS28390	COG3201	nicotinamide mononucleotide transporter
A6E92_RS28400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6E92_RS28405	COG0140	phosphoribosyl-ATP diphosphatase activity
A6E92_RS28410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6E92_RS28455	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS28480	COG1216	Glycosyl transferase, family 2
A6E92_RS28485	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6E92_RS28495	COG2270	Major facilitator Superfamily
A6E92_RS28505	COG2364	Membrane
A6E92_RS28575	COG2018	Roadblock/LC7 domain
A6E92_RS28605	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A6E92_RS28620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6E92_RS28630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6E92_RS28660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6E92_RS28680	COG1716	ATPase activity
A6E92_RS28700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6E92_RS28710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6E92_RS28710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6E92_RS28745	COG1695	Transcriptional regulator
A6E92_RS28785	COG0697	spore germination
A6E92_RS28815	COG0583	DNA-binding transcription factor activity
A6E92_RS28835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6E92_RS28850	COG0640	Transcriptional regulator
A6E92_RS28885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6E92_RS28900	COG2318	DinB family
A6E92_RS28940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6E92_RS28955	COG1968	undecaprenyl-diphosphatase activity
A6E92_RS28970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6E92_RS29010	COG1832	CoA-binding protein
A6E92_RS29015	COG1739	Uncharacterized protein family UPF0029
A6E92_RS29020	COG0420	3'-5' exonuclease activity
A6E92_RS29025	COG0419	ATPase involved in DNA repair
A6E92_RS29040	COG0626	cystathionine gamma-synthase activity
A6E92_RS29065	COG1595	DNA-templated transcription, initiation
A6E92_RS29070	COG2188	Transcriptional regulator
A6E92_RS29075	COG1940	carbohydrate kinase activity
A6E92_RS29085	COG3663	DNA glycosylase
A6E92_RS29090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6E92_RS29115	COG2226	methyltransferase
A6E92_RS29120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6E92_RS29125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6E92_RS29130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6E92_RS29175	COG0831	urea catabolic process
A6E92_RS29180	COG0832	Belongs to the urease beta subunit family
A6E92_RS29185	COG0804	urea catabolic process
A6E92_RS29195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A6E92_RS29200	COG0829	nickel cation binding
A6E92_RS29210	COG0204	Acyl-transferase
A6E92_RS29220	COG0205	6-phosphofructokinase activity
A6E92_RS29225	COG3442	glutamine amidotransferase
A6E92_RS29235	COG0242	peptide deformylase activity
A6E92_RS29245	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS29250	COG0386	Belongs to the glutathione peroxidase family
A6E92_RS29265	COG1946	Acyl-CoA thioesterase
A6E92_RS29280	COG1793	dna ligase
A6E92_RS29285	COG1252	NADH dehydrogenase
A6E92_RS29300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6E92_RS29300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6E92_RS29325	COG1132	(ABC) transporter
A6E92_RS29340	COG0277	FAD linked oxidase domain protein
A6E92_RS29350	COG1132	(ABC) transporter
A6E92_RS29365	COG2072	flavoprotein involved in K transport
A6E92_RS29375	COG0154	amidase activity
A6E92_RS29380	COG2957	Belongs to the agmatine deiminase family
A6E92_RS29395	COG2957	Belongs to the agmatine deiminase family
A6E92_RS29400	COG2957	Belongs to the agmatine deiminase family
A6E92_RS29410	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6E92_RS29430	COG0583	DNA-binding transcription factor activity
A6E92_RS29465	COG0542	response to heat
A6E92_RS29470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6E92_RS29510	COG1335	isochorismatase
A6E92_RS29610	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS29615	COG1357	PFAM Pentapeptide repeats (8 copies)
A6E92_RS29650	COG2835	tetraacyldisaccharide 4'-kinase activity
A6E92_RS29670	COG4981	capsule polysaccharide biosynthetic process
A6E92_RS29700	COG1733	regulation of RNA biosynthetic process
A6E92_RS29710	COG1472	Belongs to the glycosyl hydrolase 3 family
A6E92_RS29720	COG1175	transmembrane transport
A6E92_RS29725	COG1653	transport
A6E92_RS29730	COG1609	Transcriptional regulator
A6E92_RS29740	COG1012	belongs to the aldehyde dehydrogenase family
A6E92_RS29745	COG0174	glutamine synthetase
A6E92_RS29750	COG2186	Transcriptional regulator
A6E92_RS29755	COG0531	amino acid
A6E92_RS29760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6E92_RS29800	COG1253	flavin adenine dinucleotide binding
A6E92_RS29830	COG0667	Aldo Keto reductase
A6E92_RS29835	COG2815	serine threonine protein kinase
A6E92_RS29835	COG0515	serine threonine protein kinase
A6E92_RS29840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6E92_RS29855	COG2706	6-phosphogluconolactonase activity
A6E92_RS29865	COG2971	BadF BadG BcrA BcrD
A6E92_RS29870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6E92_RS29890	COG2226	methyltransferase
A6E92_RS29915	COG0671	phosphoesterase, PA-phosphatase related
A6E92_RS29935	COG0584	glycerophosphoryl diester phosphodiesterase
A6E92_RS29980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A6E92_RS30000	COG1940	carbohydrate kinase activity
A6E92_RS30005	COG1660	Displays ATPase and GTPase activities
A6E92_RS30015	COG0445	tRNA wobble uridine modification
A6E92_RS30050	COG2223	nitrite transmembrane transporter activity
A6E92_RS30055	COG1940	carbohydrate kinase activity
A6E92_RS30080	COG0702	epimerase
A6E92_RS30095	COG1349	DNA-binding transcription factor activity
A6E92_RS30105	COG0464	growth
A6E92_RS30125	COG2045	Belongs to the ComB family
A6E92_RS30140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6E92_RS30160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6E92_RS30195	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6E92_RS30205	COG1132	(ABC) transporter
A6E92_RS30210	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS30215	COG0328	RNA-DNA hybrid ribonuclease activity
A6E92_RS30255	COG3250	beta-galactosidase activity
A6E92_RS30260	COG1879	ABC-type sugar transport system periplasmic component
A6E92_RS30265	COG1129	ABC transporter
A6E92_RS30275	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6E92_RS30280	COG1609	Transcriptional regulator
A6E92_RS30290	COG1874	Beta-galactosidase
A6E92_RS30290	COG0366	Alpha amylase catalytic
A6E92_RS30305	COG2207	Transcriptional regulator
A6E92_RS30315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS30320	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS30325	COG1120	ATPase activity
A6E92_RS30330	COG2837	iron assimilation
A6E92_RS30360	COG1295	ribonuclease BN
A6E92_RS30360	COG1959	2 iron, 2 sulfur cluster binding
A6E92_RS30365	COG1063	alcohol dehydrogenase
A6E92_RS30385	COG1695	Transcriptional regulator
A6E92_RS30410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6E92_RS30445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6E92_RS30455	COG1191	sigma factor activity
A6E92_RS30485	COG0488	(ABC) transporter
A6E92_RS30500	COG1461	Dihydroxyacetone kinase
A6E92_RS30505	COG2376	Dihydroxyacetone kinase
A6E92_RS30535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS30620	COG0385	Bile acid
A6E92_RS30625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E92_RS30630	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6E92_RS30640	COG1129	ABC transporter
A6E92_RS30645	COG1869	D-ribose catabolic process
A6E92_RS30650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6E92_RS30655	COG2188	Transcriptional regulator
A6E92_RS30665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6E92_RS30670	COG3457	Alanine racemase
A6E92_RS30675	COG0626	cystathionine gamma-synthase activity
A6E92_RS30680	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A6E92_RS30700	COG2188	Transcriptional regulator
A6E92_RS30710	COG0798	PFAM Bile acid sodium symporter
A6E92_RS30715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6E92_RS30720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6E92_RS30725	COG0573	inorganic phosphate transmembrane transporter activity
A6E92_RS30730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6E92_RS30755	COG0243	molybdopterin cofactor binding
A6E92_RS30760	COG0640	Transcriptional regulator
A6E92_RS30765	COG2197	response regulator
A6E92_RS30770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6E92_RS30775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6E92_RS30780	COG0504	CTP synthase activity
A6E92_RS30800	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6E92_RS30810	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6E92_RS30815	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6E92_RS30820	COG1132	(ABC) transporter
A6E92_RS30825	COG1132	(ABC) transporter
A6E92_RS30860	COG0640	Transcriptional regulator
A6E92_RS30880	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A6E92_RS30885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS30890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS30895	COG1120	ATPase activity
A6E92_RS30905	COG1132	(ABC) transporter
A6E92_RS30915	COG1132	(ABC) transporter
A6E92_RS30920	COG2382	esterase
A6E92_RS30930	COG0589	response to stress
A6E92_RS30965	COG1349	DNA-binding transcription factor activity
A6E92_RS30980	COG0395	ABC-type sugar transport system, permease component
A6E92_RS30985	COG1063	alcohol dehydrogenase
A6E92_RS31000	COG1470	cell adhesion involved in biofilm formation
A6E92_RS31020	COG3845	ABC transporter
A6E92_RS31055	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6E92_RS31130	COG3433	isochorismatase activity
A6E92_RS31130	COG1535	isochorismatase
A6E92_RS31135	COG1535	isochorismatase
A6E92_RS31135	COG3433	isochorismatase activity
A6E92_RS31140	COG1021	2,3-dihydroxybenzoate-AMP ligase
A6E92_RS31145	COG1169	isochorismate synthase
A6E92_RS31150	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS31155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E92_RS31160	COG2382	esterase
A6E92_RS31165	COG0477	Major facilitator Superfamily
A6E92_RS31175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS31185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6E92_RS31190	COG1120	ATPase activity
A6E92_RS31215	COG2365	Tyrosine phosphatase family
A6E92_RS31275	COG2080	2 iron, 2 sulfur cluster binding
A6E92_RS31280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6E92_RS31285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6E92_RS31300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6E92_RS31310	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A6E92_RS31310	COG2066	Belongs to the glutaminase family
A6E92_RS31315	COG2356	endonuclease I
A6E92_RS31330	COG2813	Specifically methylates the guanine in position
A6E92_RS31335	COG1960	acyl-CoA dehydrogenase activity
A6E92_RS31370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6E92_RS31380	COG0517	IMP dehydrogenase activity
A6E92_RS31380	COG1227	inorganic diphosphatase activity
A6E92_RS31385	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6E92_RS31390	COG1063	alcohol dehydrogenase
A6E92_RS31420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6E92_RS31435	COG0640	Transcriptional regulator
A6E92_RS31450	COG0517	IMP dehydrogenase activity
A6E92_RS31450	COG0516	GMP reductase activity
A6E92_RS31455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6E92_RS31475	COG1017	nitric oxide dioxygenase activity
A6E92_RS31475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6E92_RS31480	COG0745	RESPONSE REGULATOR receiver
A6E92_RS31485	COG2205	protein histidine kinase activity
A6E92_RS31490	COG0531	amino acid
A6E92_RS31510	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS31510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6E92_RS31510	COG0300	oxidoreductase activity
A6E92_RS31510	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS31510	COG3321	synthase
A6E92_RS31515	COG3321	synthase
A6E92_RS31515	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A6E92_RS31515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6E92_RS31515	COG3321	synthase
A6E92_RS31515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6E92_RS31515	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A6E92_RS31515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6E92_RS31515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6E92_RS31525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6E92_RS31540	COG0346	lactoylglutathione lyase activity
A6E92_RS31545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6E92_RS31555	COG0515	serine threonine protein kinase
A6E92_RS31565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6E92_RS31570	COG2070	2-Nitropropane dioxygenase
A6E92_RS31575	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS31580	COG2366	antibiotic biosynthetic process
A6E92_RS31585	COG0318	PFAM AMP-dependent synthetase and ligase
A6E92_RS31595	COG0765	amino acid transport
A6E92_RS31610	COG0596	Alpha beta hydrolase
A6E92_RS31620	COG1024	Enoyl-CoA hydratase
A6E92_RS31680	COG0254	rRNA binding
A6E92_RS31755	COG1349	DNA-binding transcription factor activity
A6E92_RS31795	COG1653	transport
A6E92_RS31800	COG1175	transmembrane transport
A6E92_RS31805	COG0395	ABC-type sugar transport system, permease component
A6E92_RS31810	COG0366	Alpha amylase catalytic
A6E92_RS31815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6E92_RS31820	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
A6E92_RS31840	COG0642	Histidine kinase
A6E92_RS31870	COG0702	epimerase
A6E92_RS31885	COG1064	alcohol dehydrogenase
A6E92_RS31890	COG0640	Transcriptional regulator
A6E92_RS31895	COG1902	pentaerythritol trinitrate reductase activity
A6E92_RS31905	COG0277	FAD linked oxidase domain protein
A6E92_RS31930	COG0789	Transcriptional regulator
A6E92_RS31940	COG1764	response to oxidative stress
A6E92_RS31945	COG1846	Transcriptional regulator
A6E92_RS31955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6E92_RS32040	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS32045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6E92_RS32060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6E92_RS32075	COG0477	Major facilitator Superfamily
A6E92_RS32080	COG0367	asparagine synthase
A6E92_RS32135	COG1028	Short-chain dehydrogenase reductase Sdr
A6E92_RS32145	COG1695	Transcriptional regulator
A6E92_RS32375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6E92_RS32375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6E92_RS32475	COG1051	belongs to the nudix hydrolase family
A6E92_RS32505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6E92_RS32515	COG4974	Belongs to the 'phage' integrase family
A6E92_RS32520	COG4974	Belongs to the 'phage' integrase family
A6E92_RS32580	COG1475	DNA binding
A6E92_RS32605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6E92_RS32610	COG0587	DNA-directed DNA polymerase activity
A6E92_RS32615	COG0640	Transcriptional regulator
A6E92_RS32630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A6E92_RS32645	COG1191	sigma factor activity