locus-tag	class	description
A8713_RS00025	COG1846	Transcriptional regulator
A8713_RS00060	COG0309	Hydrogenase expression formation protein (HypE)
A8713_RS00080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A8713_RS00085	COG0375	protein maturation
A8713_RS00105	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A8713_RS00125	COG0659	secondary active sulfate transmembrane transporter activity
A8713_RS00135	COG1846	Transcriptional regulator
A8713_RS00140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A8713_RS00160	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A8713_RS00165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS00260	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A8713_RS00280	COG1120	ATPase activity
A8713_RS00285	COG2207	Transcriptional regulator
A8713_RS00290	COG0531	amino acid
A8713_RS00295	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A8713_RS00300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8713_RS00315	COG0673	inositol 2-dehydrogenase activity
A8713_RS00335	COG0395	ABC-type sugar transport system, permease component
A8713_RS00340	COG4209	transmembrane transport
A8713_RS00350	COG1609	Transcriptional regulator
A8713_RS00390	COG1120	ATPase activity
A8713_RS00395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS00400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS00420	COG1535	isochorismatase
A8713_RS00420	COG3433	isochorismatase activity
A8713_RS00435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8713_RS00445	COG0475	glutathione-regulated potassium exporter activity
A8713_RS00450	COG0475	glutathione-regulated potassium exporter activity
A8713_RS00450	COG0569	domain protein
A8713_RS00470	COG2124	cytochrome p450
A8713_RS00500	COG0477	Major facilitator Superfamily
A8713_RS00505	COG0745	RESPONSE REGULATOR receiver
A8713_RS00510	COG2267	carboxylic ester hydrolase activity
A8713_RS00520	COG2226	methyltransferase
A8713_RS00600	COG2814	Major facilitator Superfamily
A8713_RS00610	COG0601	transmembrane transport
A8713_RS00615	COG4171	peptide transport system, permease
A8713_RS00625	COG4106	trans-aconitate 2-methyltransferase activity
A8713_RS00660	COG2124	cytochrome p450
A8713_RS00665	COG2124	cytochrome p450
A8713_RS00675	COG1335	isochorismatase
A8713_RS00720	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS00730	COG4172	Belongs to the ABC transporter superfamily
A8713_RS00745	COG0747	negative chemotaxis
A8713_RS00775	COG1228	amidohydrolase
A8713_RS00785	COG0667	Aldo Keto reductase
A8713_RS00795	COG2814	Major facilitator Superfamily
A8713_RS00805	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS00810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8713_RS00815	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8713_RS00850	COG1846	Transcriptional regulator
A8713_RS00855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A8713_RS00860	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS00870	COG1309	transcriptional regulator
A8713_RS00885	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS00890	COG4689	acetoacetate decarboxylase
A8713_RS00905	COG0174	glutamine synthetase
A8713_RS00995	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A8713_RS01065	COG2226	methyltransferase
A8713_RS01125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8713_RS01130	COG0667	Aldo Keto reductase
A8713_RS01135	COG1309	transcriptional regulator
A8713_RS01160	COG0477	Major facilitator Superfamily
A8713_RS01175	COG2813	Specifically methylates the guanine in position
A8713_RS01205	COG1113	amino acid transport
A8713_RS01210	COG2362	D-Aminopeptidase
A8713_RS01220	COG2508	Transcriptional regulator
A8713_RS01220	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A8713_RS01235	COG3959	Transketolase, thiamine diphosphate binding domain
A8713_RS01240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8713_RS01275	COG2124	cytochrome p450
A8713_RS01280	COG2340	Cysteine-rich secretory protein family
A8713_RS01285	COG1609	Transcriptional regulator
A8713_RS01305	COG1879	ABC-type sugar transport system periplasmic component
A8713_RS01310	COG1129	ABC transporter
A8713_RS01315	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8713_RS01325	COG1609	Transcriptional regulator
A8713_RS01380	COG1674	ftsk spoiiie
A8713_RS01390	COG1404	Belongs to the peptidase S8 family
A8713_RS01410	COG1733	regulation of RNA biosynthetic process
A8713_RS01415	COG2130	NADP-dependent
A8713_RS01420	COG0789	Transcriptional regulator
A8713_RS01425	COG1309	transcriptional regulator
A8713_RS01430	COG2814	Major facilitator Superfamily
A8713_RS01455	COG0702	epimerase
A8713_RS01460	COG1984	allophanate hydrolase subunit 2
A8713_RS01465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8713_RS01470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A8713_RS01485	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A8713_RS01495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A8713_RS01505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS01525	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8713_RS01530	COG1309	transcriptional regulator
A8713_RS01555	COG0583	DNA-binding transcription factor activity
A8713_RS01595	COG0346	lactoylglutathione lyase activity
A8713_RS01605	COG0137	argininosuccinate synthase activity
A8713_RS01615	COG1609	Transcriptional regulator
A8713_RS01630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A8713_RS01660	COG0831	urea catabolic process
A8713_RS01665	COG0832	Belongs to the urease beta subunit family
A8713_RS01665	COG0831	urea catabolic process
A8713_RS01670	COG0804	urea catabolic process
A8713_RS01675	COG0830	nickel cation binding
A8713_RS01680	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A8713_RS01685	COG0829	nickel cation binding
A8713_RS01700	COG1953	Uracil, thiamine, allantoin
A8713_RS01725	COG0277	FAD linked oxidase domain protein
A8713_RS01730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8713_RS01735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8713_RS01770	COG1472	Belongs to the glycosyl hydrolase 3 family
A8713_RS01805	COG0385	Bile acid
A8713_RS01815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8713_RS01825	COG2814	Major facilitator Superfamily
A8713_RS01830	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
A8713_RS01835	COG1501	Belongs to the glycosyl hydrolase 31 family
A8713_RS01840	COG1609	Transcriptional regulator
A8713_RS01845	COG1653	transport
A8713_RS01850	COG1175	transmembrane transport
A8713_RS01855	COG0395	ABC-type sugar transport system, permease component
A8713_RS01880	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A8713_RS01900	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A8713_RS01905	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A8713_RS01910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A8713_RS01930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8713_RS01950	COG2814	Major facilitator Superfamily
A8713_RS01965	COG3290	protein histidine kinase activity
A8713_RS01985	COG1119	ATPase activity
A8713_RS01990	COG2132	Multicopper oxidase
A8713_RS02010	COG2124	cytochrome p450
A8713_RS02030	COG2308	Evidence 4 Homologs of previously reported genes of
A8713_RS02030	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A8713_RS02040	COG0437	4 iron, 4 sulfur cluster binding
A8713_RS02050	COG0243	molybdopterin cofactor binding
A8713_RS02050	COG3383	formate dehydrogenase (NAD+) activity
A8713_RS02055	COG3383	formate dehydrogenase (NAD+) activity
A8713_RS02055	COG0243	molybdopterin cofactor binding
A8713_RS02060	COG0709	Synthesizes selenophosphate from selenide and ATP
A8713_RS02100	COG0596	Alpha beta hydrolase
A8713_RS02100	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8713_RS02130	COG2124	cytochrome p450
A8713_RS02150	COG0477	Major facilitator Superfamily
A8713_RS02155	COG1191	sigma factor activity
A8713_RS02160	COG0753	catalase activity
A8713_RS02185	COG2080	2 iron, 2 sulfur cluster binding
A8713_RS02190	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A8713_RS02195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8713_RS02255	COG0673	inositol 2-dehydrogenase activity
A8713_RS02280	COG0009	L-threonylcarbamoyladenylate synthase
A8713_RS02305	COG3285	dna ligase
A8713_RS02305	COG1793	dna ligase
A8713_RS02325	COG0181	hydroxymethylbilane synthase activity
A8713_RS02335	COG0842	Transport permease protein
A8713_RS02345	COG1846	Transcriptional regulator
A8713_RS02390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8713_RS02395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A8713_RS02450	COG0477	Major facilitator Superfamily
A8713_RS02460	COG2205	protein histidine kinase activity
A8713_RS02510	COG0492	ferredoxin-NADP+ reductase activity
A8713_RS02515	COG3852	Histidine kinase
A8713_RS02540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS02550	COG0667	Aldo Keto reductase
A8713_RS02560	COG0328	RNA-DNA hybrid ribonuclease activity
A8713_RS02575	COG0740	serine-type endopeptidase activity
A8713_RS02580	COG0740	serine-type endopeptidase activity
A8713_RS02585	COG1396	sequence-specific DNA binding
A8713_RS02610	COG0667	Aldo Keto reductase
A8713_RS02615	COG0583	DNA-binding transcription factor activity
A8713_RS02630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A8713_RS02635	COG0346	lactoylglutathione lyase activity
A8713_RS02655	COG0431	NADPH-dependent FMN reductase
A8713_RS02690	COG0367	asparagine synthase
A8713_RS02700	COG0673	inositol 2-dehydrogenase activity
A8713_RS02745	COG0596	Alpha beta hydrolase
A8713_RS02770	COG2366	antibiotic biosynthetic process
A8713_RS02775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8713_RS02830	COG0650	Formate hydrogenlyase subunit 4
A8713_RS02840	COG0651	ATP synthesis coupled electron transport
A8713_RS02845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS02845	COG0649	NAD binding
A8713_RS02845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS02850	COG3260	NADH ubiquinone oxidoreductase 20
A8713_RS02855	COG0651	ATP synthesis coupled electron transport
A8713_RS02865	COG1993	acr, cog1993
A8713_RS02895	COG1193	negative regulation of DNA recombination
A8713_RS02900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8713_RS02910	COG2376	Dihydroxyacetone kinase
A8713_RS02915	COG1461	Dihydroxyacetone kinase
A8713_RS02920	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A8713_RS02945	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8713_RS02945	COG1902	pentaerythritol trinitrate reductase activity
A8713_RS02960	COG2890	protein-(glutamine-N5) methyltransferase activity
A8713_RS02985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8713_RS02995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8713_RS03000	COG1686	Belongs to the peptidase S11 family
A8713_RS03010	COG2186	Transcriptional regulator
A8713_RS03015	COG1968	undecaprenyl-diphosphatase activity
A8713_RS03035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8713_RS03040	COG1414	Transcriptional regulator
A8713_RS03050	COG0456	acetyltransferase
A8713_RS03065	COG0701	Predicted permease
A8713_RS03070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8713_RS03095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8713_RS03100	COG2197	response regulator
A8713_RS03105	COG4585	Histidine kinase
A8713_RS03110	COG2409	Drug exporters of the RND superfamily
A8713_RS03140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8713_RS03145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8713_RS03185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8713_RS03245	COG2807	transmembrane transport
A8713_RS03255	COG2197	response regulator
A8713_RS03260	COG4585	Histidine kinase
A8713_RS03270	COG0667	Aldo Keto reductase
A8713_RS03290	COG3467	pyridoxamine 5'-phosphate
A8713_RS03330	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS03355	COG1215	transferase activity, transferring glycosyl groups
A8713_RS03380	COG0464	growth
A8713_RS03390	COG1349	DNA-binding transcription factor activity
A8713_RS03425	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A8713_RS03435	COG1940	carbohydrate kinase activity
A8713_RS03445	COG2813	Specifically methylates the guanine in position
A8713_RS03450	COG0191	fructose-bisphosphate aldolase activity
A8713_RS03455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8713_RS03460	COG1349	DNA-binding transcription factor activity
A8713_RS03470	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A8713_RS03485	COG0542	response to heat
A8713_RS03495	COG2197	response regulator
A8713_RS03500	COG4585	Histidine kinase
A8713_RS03505	COG0445	tRNA wobble uridine modification
A8713_RS03545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A8713_RS03600	COG0584	glycerophosphoryl diester phosphodiesterase
A8713_RS03640	COG0671	phosphoesterase, PA-phosphatase related
A8713_RS03650	COG1309	transcriptional regulator
A8713_RS03660	COG1309	transcriptional regulator
A8713_RS03665	COG0640	Transcriptional regulator
A8713_RS03670	COG1902	pentaerythritol trinitrate reductase activity
A8713_RS03690	COG1960	acyl-CoA dehydrogenase activity
A8713_RS03700	COG4585	Histidine kinase
A8713_RS03705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8713_RS03720	COG2706	6-phosphogluconolactonase activity
A8713_RS03745	COG2124	cytochrome p450
A8713_RS03765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8713_RS03770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A8713_RS03775	COG2080	2 iron, 2 sulfur cluster binding
A8713_RS03790	COG0432	Pfam Uncharacterised protein family UPF0047
A8713_RS03795	COG2072	flavoprotein involved in K transport
A8713_RS03800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8713_RS03805	COG1132	(ABC) transporter
A8713_RS03820	COG1132	(ABC) transporter
A8713_RS03825	COG1132	(ABC) transporter
A8713_RS03835	COG0254	rRNA binding
A8713_RS03850	COG1946	Acyl-CoA thioesterase
A8713_RS03860	COG2018	Roadblock/LC7 domain
A8713_RS03905	COG3239	Fatty acid desaturase
A8713_RS03910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8713_RS03925	COG2115	Belongs to the xylose isomerase family
A8713_RS03930	COG1070	Carbohydrate kinase
A8713_RS03970	COG1960	acyl-CoA dehydrogenase activity
A8713_RS03975	COG1960	acyl-CoA dehydrogenase activity
A8713_RS03990	COG3634	alkyl hydroperoxide reductase activity
A8713_RS03995	COG1793	dna ligase
A8713_RS04015	COG3424	synthase
A8713_RS04020	COG2124	cytochrome p450
A8713_RS04030	COG1960	acyl-CoA dehydrogenase activity
A8713_RS04040	COG0242	peptide deformylase activity
A8713_RS04050	COG3442	glutamine amidotransferase
A8713_RS04055	COG0205	6-phosphofructokinase activity
A8713_RS04065	COG3275	phosphorelay sensor kinase activity
A8713_RS04070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8713_RS04080	COG3279	Response regulator of the LytR AlgR family
A8713_RS04085	COG1522	sequence-specific DNA binding
A8713_RS04090	COG1834	amidinotransferase
A8713_RS04095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8713_RS04100	COG0517	IMP dehydrogenase activity
A8713_RS04125	COG0586	Pfam SNARE associated Golgi protein
A8713_RS04130	COG0204	Acyl-transferase
A8713_RS04165	COG0156	8-amino-7-oxononanoate synthase activity
A8713_RS04170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A8713_RS04175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8713_RS04180	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A8713_RS04195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS04200	COG0456	acetyltransferase
A8713_RS04220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8713_RS04225	COG3663	DNA glycosylase
A8713_RS04235	COG1940	carbohydrate kinase activity
A8713_RS04240	COG2188	Transcriptional regulator
A8713_RS04245	COG2267	carboxylic ester hydrolase activity
A8713_RS04255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8713_RS04280	COG0626	cystathionine gamma-synthase activity
A8713_RS04300	COG1522	sequence-specific DNA binding
A8713_RS04305	COG0419	ATPase involved in DNA repair
A8713_RS04315	COG1739	Uncharacterized protein family UPF0029
A8713_RS04325	COG0215	cysteine-tRNA ligase activity
A8713_RS04330	COG1832	CoA-binding protein
A8713_RS04375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8713_RS04385	COG1968	undecaprenyl-diphosphatase activity
A8713_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS04405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A8713_RS04425	COG2318	DinB family
A8713_RS04440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8713_RS04465	COG0583	DNA-binding transcription factor activity
A8713_RS04470	COG0697	spore germination
A8713_RS04510	COG0384	phenazine biosynthesis protein PhzF
A8713_RS04560	COG0725	ABC transporter, periplasmic molybdate-binding protein
A8713_RS04575	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8713_RS04575	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8713_RS04585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8713_RS04625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8713_RS04660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8713_RS04675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8713_RS04680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8713_RS04695	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A8713_RS04700	COG5002	protein histidine kinase activity
A8713_RS04700	COG3447	MASE1 domain protein
A8713_RS04700	COG5001	Diguanylate cyclase
A8713_RS04705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8713_RS04720	COG2018	Roadblock/LC7 domain
A8713_RS04755	COG0438	transferase activity, transferring glycosyl groups
A8713_RS04785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8713_RS04795	COG0584	glycerophosphoryl diester phosphodiesterase
A8713_RS04800	COG2270	Major facilitator Superfamily
A8713_RS04810	COG3030	protein affecting phage T7 exclusion by the F plasmid
A8713_RS04815	COG0463	Glycosyl transferase, family 2
A8713_RS04835	COG1960	acyl-CoA dehydrogenase activity
A8713_RS04880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8713_RS04885	COG0140	phosphoribosyl-ATP diphosphatase activity
A8713_RS04890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8713_RS04895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8713_RS04895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8713_RS04900	COG3201	nicotinamide mononucleotide transporter
A8713_RS04915	COG1940	carbohydrate kinase activity
A8713_RS04920	COG0738	Major facilitator superfamily
A8713_RS04930	COG2233	PERMEase
A8713_RS04950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8713_RS04965	COG0531	amino acid
A8713_RS04985	COG2390	Transcriptional regulator
A8713_RS04990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8713_RS05000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8713_RS05015	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8713_RS05025	COG1758	RNA polymerase activity
A8713_RS05030	COG0194	GDP metabolic process
A8713_RS05040	COG0284	orotidine-5'-phosphate decarboxylase activity
A8713_RS05045	COG0167	dihydroorotate dehydrogenase activity
A8713_RS05050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8713_RS05055	COG0505	Belongs to the CarA family
A8713_RS05065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8713_RS05070	COG0540	Belongs to the ATCase OTCase family
A8713_RS05075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A8713_RS05085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8713_RS05090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8713_RS05095	COG0006	proline dipeptidase activity
A8713_RS05105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8713_RS05110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8713_RS05115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8713_RS05120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8713_RS05125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8713_RS05130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8713_RS05150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A8713_RS05175	COG0124	histidyl-tRNA synthetase
A8713_RS05185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8713_RS05190	COG1196	nuclear chromosome segregation
A8713_RS05195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8713_RS05200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8713_RS05205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8713_RS05210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8713_RS05220	COG2255	four-way junction helicase activity
A8713_RS05225	COG0632	four-way junction helicase activity
A8713_RS05230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A8713_RS05235	COG0217	transcriptional regulatory protein
A8713_RS05240	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A8713_RS05245	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A8713_RS05255	COG0438	transferase activity, transferring glycosyl groups
A8713_RS05260	COG1560	Kdo2-lipid A biosynthetic process
A8713_RS05265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8713_RS05285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8713_RS05300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8713_RS05355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8713_RS05410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8713_RS05410	COG1648	precorrin-2 dehydrogenase activity
A8713_RS05415	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A8713_RS05430	COG1464	Belongs to the NlpA lipoprotein family
A8713_RS05435	COG2011	ABC-type metal ion transport system permease component
A8713_RS05440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8713_RS05470	COG0204	Acyl-transferase
A8713_RS05470	COG0318	PFAM AMP-dependent synthetase and ligase
A8713_RS05475	COG0477	Major facilitator Superfamily
A8713_RS05490	COG0165	Argininosuccinate lyase
A8713_RS05500	COG1438	arginine binding
A8713_RS05505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8713_RS05510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8713_RS05515	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A8713_RS05520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8713_RS05530	COG0463	Glycosyl transferase, family 2
A8713_RS05540	COG0789	Transcriptional regulator
A8713_RS05565	COG0697	spore germination
A8713_RS05575	COG1649	PFAM Uncharacterised BCR, COG1649
A8713_RS05605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8713_RS05605	COG0072	phenylalanine-tRNA ligase activity
A8713_RS05610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8713_RS05615	COG5002	protein histidine kinase activity
A8713_RS05620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8713_RS05625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8713_RS05630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8713_RS05635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8713_RS05685	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS05690	COG0174	glutamine synthetase
A8713_RS05695	COG2186	Transcriptional regulator
A8713_RS05700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A8713_RS05725	COG4176	ABC-type proline glycine betaine transport system permease component
A8713_RS05730	COG0517	IMP dehydrogenase activity
A8713_RS05730	COG4175	Glycine betaine
A8713_RS05735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8713_RS05785	COG0805	protein transport
A8713_RS05790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8713_RS05810	COG2378	regulation of single-species biofilm formation
A8713_RS05820	COG0545	Peptidyl-prolyl cis-trans isomerase
A8713_RS05825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A8713_RS05835	COG1609	Transcriptional regulator
A8713_RS05840	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A8713_RS05845	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A8713_RS05855	COG4122	O-methyltransferase activity
A8713_RS05860	COG1222	aaa ATPase
A8713_RS05880	COG0517	IMP dehydrogenase activity
A8713_RS05880	COG1994	Peptidase M50
A8713_RS05890	COG2197	response regulator
A8713_RS05895	COG4166	transmembrane transport
A8713_RS05900	COG0546	phosphoglycolate phosphatase activity
A8713_RS05905	COG1410	methionine synthase
A8713_RS05905	COG0646	methionine synthase
A8713_RS05910	COG1414	Transcriptional regulator
A8713_RS05915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8713_RS05920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8713_RS05925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8713_RS05930	COG2186	Transcriptional regulator
A8713_RS05940	COG0215	cysteine-tRNA ligase activity
A8713_RS05960	COG0598	Magnesium transport protein CorA
A8713_RS05965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS05970	COG0667	Aldo Keto reductase
A8713_RS06020	COG3012	SEC-C Motif Domain Protein
A8713_RS06025	COG2186	Transcriptional regulator
A8713_RS06030	COG3265	gluconokinase activity
A8713_RS06055	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A8713_RS06060	COG2149	membrane
A8713_RS06080	COG0318	PFAM AMP-dependent synthetase and ligase
A8713_RS06090	COG3876	Protein conserved in bacteria
A8713_RS06135	COG1960	acyl-CoA dehydrogenase activity
A8713_RS06145	COG0640	Transcriptional regulator
A8713_RS06165	COG3842	ATPase activity
A8713_RS06180	COG1309	transcriptional regulator
A8713_RS06190	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A8713_RS06195	COG2188	Transcriptional regulator
A8713_RS06225	COG2755	lipolytic protein G-D-S-L family
A8713_RS06240	COG1725	Transcriptional regulator
A8713_RS06255	COG4106	trans-aconitate 2-methyltransferase activity
A8713_RS06285	COG0587	DNA-directed DNA polymerase activity
A8713_RS06310	COG1126	abc transporter atp-binding protein
A8713_RS06320	COG0765	amino acid transport
A8713_RS06325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8713_RS06335	COG1799	cell septum assembly
A8713_RS06340	COG1960	acyl-CoA dehydrogenase activity
A8713_RS06345	COG0477	Major facilitator Superfamily
A8713_RS06355	COG0671	phosphoesterase, PA-phosphatase related
A8713_RS06375	COG1160	GTP binding
A8713_RS06385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A8713_RS06415	COG1187	pseudouridine synthase activity
A8713_RS06420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A8713_RS06425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A8713_RS06440	COG0686	Belongs to the AlaDH PNT family
A8713_RS06450	COG0494	nUDIX hydrolase
A8713_RS06455	COG0504	CTP synthase activity
A8713_RS06460	COG3387	PFAM Glycoside hydrolase 15-related
A8713_RS06475	COG0438	transferase activity, transferring glycosyl groups
A8713_RS06485	COG0497	DNA recombination
A8713_RS06490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8713_RS06510	COG1120	ATPase activity
A8713_RS06515	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS06520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS06525	COG0647	UMP catabolic process
A8713_RS06560	COG2094	Belongs to the DNA glycosylase MPG family
A8713_RS06570	COG1881	PFAM PEBP family protein
A8713_RS06590	COG1119	ATPase activity
A8713_RS06605	COG2197	response regulator
A8713_RS06620	COG0842	Transport permease protein
A8713_RS06620	COG1131	(ABC) transporter
A8713_RS06620	COG1716	ATPase activity
A8713_RS06625	COG0560	Phosphoserine phosphatase
A8713_RS06625	COG3830	Belongs to the UPF0237 family
A8713_RS06630	COG0588	phosphoglycerate mutase activity
A8713_RS06645	COG2186	Transcriptional regulator
A8713_RS06655	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS06670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8713_RS06690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A8713_RS06695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8713_RS06710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8713_RS06720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8713_RS06730	COG3346	SURF1 family
A8713_RS06750	COG0488	(ABC) transporter
A8713_RS06760	COG3547	Transposase (IS116 IS110 IS902 family)
A8713_RS06775	COG0235	Class ii aldolase
A8713_RS06815	COG1492	cobalamin metabolic process
A8713_RS06830	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A8713_RS06835	COG1797	cobyrinic acid a,c-diamide synthase activity
A8713_RS06890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A8713_RS06895	COG0456	acetyltransferase
A8713_RS06900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8713_RS06905	COG1917	Cupin 2, conserved barrel domain protein
A8713_RS06910	COG5285	phytanoyl-CoA dioxygenase
A8713_RS06935	COG1414	Transcriptional regulator
A8713_RS06945	COG4585	Histidine kinase
A8713_RS06950	COG2197	response regulator
A8713_RS06955	COG0768	penicillin binding
A8713_RS06960	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A8713_RS06975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8713_RS06980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8713_RS06985	COG1349	DNA-binding transcription factor activity
A8713_RS07000	COG0395	ABC-type sugar transport system, permease component
A8713_RS07005	COG1063	alcohol dehydrogenase
A8713_RS07060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8713_RS07070	COG2171	N-acyltransferase activity
A8713_RS07075	COG3226	Transcriptional regulator
A8713_RS07085	COG2151	metal-sulfur cluster biosynthetic enzyme
A8713_RS07090	COG0822	iron-sulfur transferase activity
A8713_RS07095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8713_RS07100	COG0396	ATPase activity
A8713_RS07110	COG0719	Fe-S assembly protein
A8713_RS07125	COG2746	aminoglycoside 3-N-acetyltransferase activity
A8713_RS07140	COG1612	heme a metabolic process
A8713_RS07150	COG0109	protoheme IX farnesyltransferase activity
A8713_RS07160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8713_RS07175	COG0363	glucosamine-6-phosphate deaminase activity
A8713_RS07195	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8713_RS07200	COG0149	triose-phosphate isomerase activity
A8713_RS07205	COG0126	phosphoglycerate kinase activity
A8713_RS07210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8713_RS07220	COG1481	regulation of sporulation
A8713_RS07225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A8713_RS07230	COG1660	Displays ATPase and GTPase activities
A8713_RS07235	COG0322	excinuclease ABC activity
A8713_RS07250	COG1609	Transcriptional regulator
A8713_RS07260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8713_RS07270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8713_RS07275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A8713_RS07280	COG0387	Pfam Sodium calcium exchanger
A8713_RS07300	COG0556	nucleotide-excision repair
A8713_RS07310	COG0584	glycerophosphoryl diester phosphodiesterase
A8713_RS07325	COG2313	pseudouridylate synthase activity
A8713_RS07335	COG2226	methyltransferase
A8713_RS07385	COG2267	carboxylic ester hydrolase activity
A8713_RS07410	COG0237	dephospho-CoA kinase activity
A8713_RS07425	COG0539	negative regulation of cytoplasmic translation
A8713_RS07430	COG2226	methyltransferase
A8713_RS07435	COG1643	Atp-dependent helicase
A8713_RS07465	COG2050	protein possibly involved in aromatic compounds catabolism
A8713_RS07470	COG0683	leucine binding
A8713_RS07520	COG0737	Belongs to the 5'-nucleotidase family
A8713_RS07535	COG0702	epimerase
A8713_RS07545	COG0287	Prephenate dehydrogenase
A8713_RS07545	COG1605	Chorismate mutase
A8713_RS07555	COG0667	Aldo Keto reductase
A8713_RS07560	COG2304	oxidoreductase activity
A8713_RS07570	COG0069	glutamate synthase activity
A8713_RS07570	COG0070	glutamate synthase
A8713_RS07570	COG0067	glutamate synthase
A8713_RS07600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8713_RS07610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8713_RS07620	COG0159	tryptophan synthase activity
A8713_RS07625	COG0133	tryptophan synthase activity
A8713_RS07630	COG0134	indole-3-glycerol-phosphate synthase activity
A8713_RS07655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8713_RS07675	COG0107	imidazoleglycerol-phosphate synthase activity
A8713_RS07680	COG0251	oxidation-reduction process
A8713_RS07685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8713_RS07690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A8713_RS07695	COG0131	Imidazoleglycerol-phosphate dehydratase
A8713_RS07700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8713_RS07705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8713_RS07725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8713_RS07745	COG1432	Conserved Protein
A8713_RS07750	COG0587	DNA-directed DNA polymerase activity
A8713_RS07805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A8713_RS07815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8713_RS07820	COG3599	regulation of cell shape
A8713_RS07830	COG1799	cell septum assembly
A8713_RS07840	COG1496	oxidoreductase activity
A8713_RS07845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8713_RS07850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8713_RS07855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8713_RS07865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8713_RS07870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8713_RS07875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8713_RS07880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8713_RS07885	COG0768	penicillin binding
A8713_RS07895	COG0275	rRNA processing
A8713_RS07905	COG0714	Associated with various cellular activities
A8713_RS07925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8713_RS07935	COG1309	transcriptional regulator
A8713_RS07940	COG1233	COG1233 Phytoene dehydrogenase and related
A8713_RS07955	COG0352	thiamine-phosphate diphosphorylase activity
A8713_RS07970	COG2022	thiamine diphosphate biosynthetic process
A8713_RS07970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8713_RS07980	COG2022	thiamine diphosphate biosynthetic process
A8713_RS07985	COG2815	serine threonine protein kinase
A8713_RS07985	COG0515	serine threonine protein kinase
A8713_RS07990	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A8713_RS07995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8713_RS08000	COG2193	ferroxidase activity
A8713_RS08010	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A8713_RS08025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8713_RS08030	COG0205	6-phosphofructokinase activity
A8713_RS08040	COG4585	Histidine kinase
A8713_RS08065	COG1940	carbohydrate kinase activity
A8713_RS08075	COG0003	Pfam Anion-transporting ATPase
A8713_RS08090	COG1022	Amp-dependent synthetase and ligase
A8713_RS08095	COG0438	transferase activity, transferring glycosyl groups
A8713_RS08140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8713_RS08145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8713_RS08150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8713_RS08155	COG0723	plastoquinol--plastocyanin reductase activity
A8713_RS08160	COG2010	Cytochrome c
A8713_RS08165	COG1845	cytochrome c oxidase, subunit III
A8713_RS08175	COG1376	ErfK ybiS ycfS ynhG family protein
A8713_RS08185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8713_RS08190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8713_RS08200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8713_RS08220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A8713_RS08245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8713_RS08250	COG2197	response regulator
A8713_RS08255	COG4585	Histidine kinase
A8713_RS08280	COG2226	methyltransferase
A8713_RS08285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8713_RS08305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A8713_RS08325	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A8713_RS08340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A8713_RS08345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8713_RS08350	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8713_RS08360	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A8713_RS08390	COG1090	epimerase
A8713_RS08405	COG0321	lipoyl(octanoyl) transferase activity
A8713_RS08410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8713_RS08430	COG0174	glutamine synthetase
A8713_RS08445	COG0501	Belongs to the peptidase M48B family
A8713_RS08465	COG0726	polysaccharide deacetylase
A8713_RS08480	COG0745	RESPONSE REGULATOR receiver
A8713_RS08495	COG2197	response regulator
A8713_RS08540	COG3833	ABC-type maltose transport systems, permease component
A8713_RS08545	COG0366	Alpha amylase catalytic
A8713_RS08550	COG1609	Transcriptional regulator
A8713_RS08560	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A8713_RS08565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8713_RS08580	COG2188	Transcriptional regulator
A8713_RS08600	COG0174	glutamine synthetase
A8713_RS08605	COG1017	nitric oxide dioxygenase activity
A8713_RS08605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8713_RS08610	COG1959	2 iron, 2 sulfur cluster binding
A8713_RS08630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8713_RS08630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A8713_RS08635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A8713_RS08640	COG0477	Major facilitator Superfamily
A8713_RS08655	COG2814	Major facilitator Superfamily
A8713_RS08680	COG1994	Peptidase M50
A8713_RS08720	COG0384	phenazine biosynthesis protein PhzF
A8713_RS08735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8713_RS08740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS08745	COG1120	ATPase activity
A8713_RS08755	COG2837	iron assimilation
A8713_RS08760	COG0672	)-iron permease
A8713_RS08775	COG1309	transcriptional regulator
A8713_RS08780	COG1834	amidinotransferase
A8713_RS08790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8713_RS08795	COG2814	Major facilitator Superfamily
A8713_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS08865	COG3022	response to hydroperoxide
A8713_RS08870	COG0800	Aldolase
A8713_RS08885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8713_RS08895	COG2030	dehydratase
A8713_RS08900	COG1131	(ABC) transporter
A8713_RS08910	COG4585	Histidine kinase
A8713_RS08915	COG2197	response regulator
A8713_RS08930	COG0477	Major facilitator Superfamily
A8713_RS08970	COG0438	transferase activity, transferring glycosyl groups
A8713_RS08975	COG1309	transcriptional regulator
A8713_RS08995	COG3845	ABC transporter
A8713_RS09020	COG3619	membrane
A8713_RS09025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8713_RS09045	COG3321	synthase
A8713_RS09045	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS09045	COG0604	alcohol dehydrogenase
A8713_RS09050	COG0154	amidase activity
A8713_RS09055	COG1309	transcriptional regulator
A8713_RS09065	COG1335	isochorismatase
A8713_RS09090	COG0667	Aldo Keto reductase
A8713_RS09115	COG4122	O-methyltransferase activity
A8713_RS09145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8713_RS09210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8713_RS09225	COG1358	cellular component organization or biogenesis
A8713_RS09275	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A8713_RS09285	COG0477	Major facilitator Superfamily
A8713_RS09290	COG1309	transcriptional regulator
A8713_RS09305	COG0789	Transcriptional regulator
A8713_RS09345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8713_RS09350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8713_RS09355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8713_RS09380	COG2084	Dehydrogenase
A8713_RS09385	COG0583	DNA-binding transcription factor activity
A8713_RS09395	COG1764	response to oxidative stress
A8713_RS09400	COG2130	NADP-dependent
A8713_RS09410	COG3848	Pyruvate phosphate dikinase
A8713_RS09410	COG0574	Belongs to the PEP-utilizing enzyme family
A8713_RS09440	COG1129	ABC transporter
A8713_RS09445	COG4214	carbohydrate transport
A8713_RS09480	COG3386	PFAM SMP-30 Gluconolaconase
A8713_RS09485	COG1414	Transcriptional regulator
A8713_RS09505	COG0318	PFAM AMP-dependent synthetase and ligase
A8713_RS09510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A8713_RS09510	COG0825	malonyl-CoA metabolic process
A8713_RS09515	COG1404	Belongs to the peptidase S8 family
A8713_RS09520	COG1077	Cell shape determining protein MreB Mrl
A8713_RS09530	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8713_RS09530	COG0515	serine threonine protein kinase
A8713_RS09555	COG1070	Carbohydrate kinase
A8713_RS09570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8713_RS09575	COG0358	DNA primase activity
A8713_RS09585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A8713_RS09590	COG2949	membrane
A8713_RS09605	COG0431	NADPH-dependent FMN reductase
A8713_RS09625	COG1309	transcriptional regulator
A8713_RS09630	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS09635	COG0395	ABC-type sugar transport system, permease component
A8713_RS09640	COG1175	transmembrane transport
A8713_RS09645	COG2182	Extracellular solute-binding protein
A8713_RS09655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8713_RS09655	COG0574	Belongs to the PEP-utilizing enzyme family
A8713_RS09670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8713_RS09705	COG2318	DinB family
A8713_RS09715	COG0477	Major facilitator Superfamily
A8713_RS09730	COG0667	Aldo Keto reductase
A8713_RS09735	COG0423	glycine-tRNA ligase activity
A8713_RS09740	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8713_RS09740	COG3443	Belongs to the bacterial solute-binding protein 9 family
A8713_RS09745	COG1121	(ABC) transporter
A8713_RS09750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8713_RS09760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8713_RS09765	COG1381	Involved in DNA repair and RecF pathway recombination
A8713_RS09770	COG2197	response regulator
A8713_RS09775	COG4585	Histidine kinase
A8713_RS09850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8713_RS09860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8713_RS09890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A8713_RS09900	COG2315	Protein conserved in bacteria
A8713_RS09920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8713_RS09935	COG4948	Mandelate Racemase Muconate Lactonizing
A8713_RS09940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A8713_RS09945	COG1234	tRNA 3'-trailer cleavage
A8713_RS09950	COG0537	adenosine 5'-monophosphoramidase activity
A8713_RS09955	COG0793	Belongs to the peptidase S41A family
A8713_RS09955	COG4946	Tricorn protease homolog
A8713_RS09980	COG0484	heat shock protein binding
A8713_RS09985	COG1420	regulation of RNA biosynthetic process
A8713_RS10015	COG0481	GTPase activity
A8713_RS10020	COG0268	Binds directly to 16S ribosomal RNA
A8713_RS10045	COG2353	YceI-like domain
A8713_RS10055	COG1555	photosystem II stabilization
A8713_RS10060	COG1307	EDD domain protein, DegV family
A8713_RS10070	COG0495	leucyl-tRNA aminoacylation
A8713_RS10095	COG0588	phosphoglycerate mutase activity
A8713_RS10100	COG0799	negative regulation of ribosome biogenesis
A8713_RS10110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A8713_RS10115	COG0501	Belongs to the peptidase M48B family
A8713_RS10130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A8713_RS10140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8713_RS10155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8713_RS10160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A8713_RS10165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A8713_RS10180	COG0438	transferase activity, transferring glycosyl groups
A8713_RS10200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8713_RS10205	COG1530	ribonuclease E activity
A8713_RS10230	COG0772	Belongs to the SEDS family
A8713_RS10235	COG0768	penicillin binding
A8713_RS10250	COG1077	Cell shape determining protein MreB Mrl
A8713_RS10255	COG0105	UTP biosynthetic process
A8713_RS10265	COG0285	dihydrofolate synthase activity
A8713_RS10270	COG0525	valine-tRNA ligase activity
A8713_RS10280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8713_RS10285	COG0740	serine-type endopeptidase activity
A8713_RS10290	COG0740	serine-type endopeptidase activity
A8713_RS10295	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8713_RS10315	COG3594	Acyltransferase
A8713_RS10325	COG1674	ftsk spoiiie
A8713_RS10380	COG4552	Acetyltransferase involved in intracellular survival and related
A8713_RS10395	COG1113	amino acid transport
A8713_RS10405	COG1940	carbohydrate kinase activity
A8713_RS10415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8713_RS10420	COG1116	anion transmembrane transporter activity
A8713_RS10435	COG1113	amino acid transport
A8713_RS10440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8713_RS10445	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8713_RS10500	COG0583	DNA-binding transcription factor activity
A8713_RS10510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8713_RS10540	COG0668	transmembrane transport
A8713_RS10555	COG1653	transport
A8713_RS10560	COG1175	transmembrane transport
A8713_RS10565	COG0395	ABC-type sugar transport system, permease component
A8713_RS10570	COG1486	melibiose metabolic process
A8713_RS10615	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8713_RS10635	COG1136	(ABC) transporter
A8713_RS10635	COG0577	efflux transmembrane transporter activity
A8713_RS10675	COG0629	single-stranded DNA binding
A8713_RS10680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8713_RS10695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8713_RS10740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8713_RS10780	COG0438	transferase activity, transferring glycosyl groups
A8713_RS10785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8713_RS10795	COG0728	peptidoglycan biosynthetic process
A8713_RS10805	COG0438	transferase activity, transferring glycosyl groups
A8713_RS10850	COG1131	(ABC) transporter
A8713_RS10865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8713_RS10895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8713_RS10900	COG3547	Transposase (IS116 IS110 IS902 family)
A8713_RS10960	COG1129	ABC transporter
A8713_RS10970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8713_RS10975	COG1869	D-ribose catabolic process
A8713_RS10990	COG0673	inositol 2-dehydrogenase activity
A8713_RS10995	COG1609	Transcriptional regulator
A8713_RS11025	COG1472	Belongs to the glycosyl hydrolase 3 family
A8713_RS11065	COG0028	Belongs to the TPP enzyme family
A8713_RS11090	COG1946	Acyl-CoA thioesterase
A8713_RS11100	COG1309	transcriptional regulator
A8713_RS11105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8713_RS11120	COG1960	acyl-CoA dehydrogenase activity
A8713_RS11150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8713_RS11155	COG0589	response to stress
A8713_RS11165	COG4977	sequence-specific DNA binding
A8713_RS11170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A8713_RS11200	COG0395	ABC-type sugar transport system, permease component
A8713_RS11225	COG3979	chitinase
A8713_RS11230	COG5002	protein histidine kinase activity
A8713_RS11260	COG0588	phosphoglycerate mutase activity
A8713_RS11310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS11325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8713_RS11330	COG0765	amino acid transport
A8713_RS11335	COG0765	amino acid transport
A8713_RS11340	COG1126	abc transporter atp-binding protein
A8713_RS11355	COG3397	chitin binding
A8713_RS11435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8713_RS11440	COG2188	Transcriptional regulator
A8713_RS11445	COG1940	carbohydrate kinase activity
A8713_RS11450	COG0673	inositol 2-dehydrogenase activity
A8713_RS11455	COG4702	Belongs to the UPF0303 family
A8713_RS11470	COG0706	membrane insertase activity
A8713_RS11500	COG0270	DNA (cytosine-5-)-methyltransferase activity
A8713_RS11525	COG1074	ATP-dependent DNA helicase activity
A8713_RS11570	COG0071	Belongs to the small heat shock protein (HSP20) family
A8713_RS11575	COG0596	Alpha beta hydrolase
A8713_RS11595	COG2733	membrane
A8713_RS11605	COG4555	ABC transporter
A8713_RS11620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8713_RS11660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8713_RS11670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A8713_RS11675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8713_RS11680	COG1263	PTS System
A8713_RS11685	COG1263	PTS System
A8713_RS11690	COG1234	tRNA 3'-trailer cleavage
A8713_RS11725	COG1113	amino acid transport
A8713_RS11735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A8713_RS11745	COG1335	isochorismatase
A8713_RS11765	COG1714	RDD family
A8713_RS11780	COG0277	FAD linked oxidase domain protein
A8713_RS11790	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A8713_RS11855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8713_RS11870	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A8713_RS11875	COG0395	ABC-type sugar transport system, permease component
A8713_RS11885	COG1653	transport
A8713_RS11895	COG1678	Uncharacterized ACR, COG1678
A8713_RS11900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8713_RS11905	COG0776	regulation of translation
A8713_RS11915	COG3973	AAA domain
A8713_RS11955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A8713_RS11980	COG0793	Belongs to the peptidase S41A family
A8713_RS11990	COG2884	Cell division ATP-binding protein ftsE
A8713_RS12005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8713_RS12010	COG0515	serine threonine protein kinase
A8713_RS12015	COG0515	serine threonine protein kinase
A8713_RS12030	COG1175	transmembrane transport
A8713_RS12035	COG0395	ABC-type sugar transport system, permease component
A8713_RS12040	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8713_RS12040	COG0463	Glycosyl transferase, family 2
A8713_RS12045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8713_RS12050	COG1216	Glycosyl transferase, family 2
A8713_RS12055	COG1764	response to oxidative stress
A8713_RS12060	COG1846	Transcriptional regulator
A8713_RS12070	COG1215	transferase activity, transferring glycosyl groups
A8713_RS12090	COG1134	teichoic acid transport
A8713_RS12100	COG2902	Dehydrogenase
A8713_RS12120	COG0653	protein targeting
A8713_RS12130	COG3214	Protein conserved in bacteria
A8713_RS12135	COG2197	response regulator
A8713_RS12140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8713_RS12150	COG0823	Involved in the tonB-independent uptake of proteins
A8713_RS12155	COG5002	protein histidine kinase activity
A8713_RS12160	COG0745	RESPONSE REGULATOR receiver
A8713_RS12165	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A8713_RS12185	COG0714	Associated with various cellular activities
A8713_RS12230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A8713_RS12245	COG1482	cell wall glycoprotein biosynthetic process
A8713_RS12255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8713_RS12290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A8713_RS12295	COG0778	Nitroreductase
A8713_RS12295	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A8713_RS12330	COG1316	TRANSCRIPTIONal
A8713_RS12335	COG1316	TRANSCRIPTIONal
A8713_RS12340	COG1316	TRANSCRIPTIONal
A8713_RS12350	COG1316	TRANSCRIPTIONal
A8713_RS12360	COG1316	TRANSCRIPTIONal
A8713_RS12380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8713_RS12400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8713_RS12415	COG2205	protein histidine kinase activity
A8713_RS12420	COG0745	RESPONSE REGULATOR receiver
A8713_RS12425	COG3104	oligopeptide transport
A8713_RS12435	COG1366	Belongs to the anti-sigma-factor antagonist family
A8713_RS12440	COG1191	sigma factor activity
A8713_RS12445	COG1228	amidohydrolase
A8713_RS12460	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A8713_RS12505	COG2755	lipolytic protein G-D-S-L family
A8713_RS12510	COG0183	Belongs to the thiolase family
A8713_RS12545	COG2814	Major facilitator Superfamily
A8713_RS12560	COG1136	(ABC) transporter
A8713_RS12565	COG0577	efflux transmembrane transporter activity
A8713_RS12570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8713_RS12575	COG1252	NADH dehydrogenase
A8713_RS12595	COG0148	phosphopyruvate hydratase activity
A8713_RS12645	COG0577	efflux transmembrane transporter activity
A8713_RS12650	COG1136	(ABC) transporter
A8713_RS12680	COG4585	Histidine kinase
A8713_RS12695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8713_RS12700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8713_RS12705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A8713_RS12710	COG0193	aminoacyl-tRNA hydrolase activity
A8713_RS12720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A8713_RS12730	COG1309	transcriptional regulator
A8713_RS12740	COG4106	trans-aconitate 2-methyltransferase activity
A8713_RS12745	COG1846	Transcriptional regulator
A8713_RS12750	COG2197	response regulator
A8713_RS12765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A8713_RS12805	COG0488	(ABC) transporter
A8713_RS12815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A8713_RS12820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8713_RS12830	COG0084	hydrolase, TatD family'
A8713_RS12860	COG2188	Transcriptional regulator
A8713_RS12885	COG0310	cobalt ion transport
A8713_RS12895	COG1122	ATPase activity
A8713_RS12915	COG0442	prolyl-tRNA aminoacylation
A8713_RS12935	COG2409	Drug exporters of the RND superfamily
A8713_RS12945	COG0793	Belongs to the peptidase S41A family
A8713_RS12945	COG4946	Tricorn protease homolog
A8713_RS12955	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS12960	COG2267	carboxylic ester hydrolase activity
A8713_RS12965	COG2072	flavoprotein involved in K transport
A8713_RS12980	COG0708	Exodeoxyribonuclease III
A8713_RS12985	COG0454	-acetyltransferase
A8713_RS13015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8713_RS13020	COG0315	cyclic pyranopterin monophosphate synthase activity
A8713_RS13020	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8713_RS13025	COG0315	cyclic pyranopterin monophosphate synthase activity
A8713_RS13035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8713_RS13040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8713_RS13080	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A8713_RS13090	COG1970	mechanosensitive ion channel activity
A8713_RS13105	COG1376	ErfK ybiS ycfS ynhG family protein
A8713_RS13120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8713_RS13120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8713_RS13120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8713_RS13130	COG1349	DNA-binding transcription factor activity
A8713_RS13135	COG0477	Major facilitator Superfamily
A8713_RS13155	COG3384	dioxygenase
A8713_RS13160	COG1846	Transcriptional regulator
A8713_RS13180	COG1414	Transcriptional regulator
A8713_RS13270	COG1595	DNA-templated transcription, initiation
A8713_RS13305	COG0386	Belongs to the glutathione peroxidase family
A8713_RS13320	COG1686	Belongs to the peptidase S11 family
A8713_RS13355	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A8713_RS13370	COG3629	intracellular signal transduction
A8713_RS13370	COG3903	Transcriptional regulator
A8713_RS13380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8713_RS13380	COG0515	serine threonine protein kinase
A8713_RS13390	COG1309	transcriptional regulator
A8713_RS13400	COG0259	pyridoxamine-phosphate oxidase activity
A8713_RS13415	COG2072	flavoprotein involved in K transport
A8713_RS13505	COG2813	Specifically methylates the guanine in position
A8713_RS13510	COG2945	thiolester hydrolase activity
A8713_RS13510	COG0596	Alpha beta hydrolase
A8713_RS13535	COG4821	SIS domain
A8713_RS13540	COG0259	pyridoxamine-phosphate oxidase activity
A8713_RS13555	COG1024	Enoyl-CoA hydratase
A8713_RS13560	COG0318	PFAM AMP-dependent synthetase and ligase
A8713_RS13575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8713_RS13590	COG5006	permease, DMT superfamily
A8713_RS13595	COG0277	FAD linked oxidase domain protein
A8713_RS13600	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A8713_RS13665	COG0667	Aldo Keto reductase
A8713_RS13685	COG1846	Transcriptional regulator
A8713_RS13695	COG2252	PERMEase
A8713_RS13705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A8713_RS13720	COG2814	Major facilitator Superfamily
A8713_RS13730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8713_RS13735	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A8713_RS13740	COG1278	Cold shock
A8713_RS13765	COG3540	Alkaline phosphatase
A8713_RS13770	COG1061	Type III restriction enzyme res subunit
A8713_RS13785	COG3973	AAA domain
A8713_RS13815	COG5632	N-Acetylmuramoyl-L-alanine amidase
A8713_RS13815	COG3409	Peptidoglycan-binding domain 1 protein
A8713_RS13850	COG1737	Transcriptional regulator
A8713_RS13855	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A8713_RS13860	COG2318	DinB family
A8713_RS13880	COG0459	protein refolding
A8713_RS13885	COG1278	Cold shock
A8713_RS13900	COG0463	Glycosyl transferase, family 2
A8713_RS13910	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A8713_RS13940	COG1105	Belongs to the carbohydrate kinase PfkB family
A8713_RS13950	COG5001	Diguanylate cyclase
A8713_RS13950	COG3300	MHYT domain
A8713_RS14045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8713_RS14050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8713_RS14080	COG3842	ATPase activity
A8713_RS14090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8713_RS14100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8713_RS14105	COG0215	cysteine-tRNA ligase activity
A8713_RS14115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A8713_RS14120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A8713_RS14125	COG1329	Transcriptional regulator
A8713_RS14140	COG5002	protein histidine kinase activity
A8713_RS14155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8713_RS14200	COG2188	Transcriptional regulator
A8713_RS14205	COG0588	phosphoglycerate mutase activity
A8713_RS14230	COG0438	transferase activity, transferring glycosyl groups
A8713_RS14295	COG2188	Transcriptional regulator
A8713_RS14305	COG2188	Transcriptional regulator
A8713_RS14310	COG4552	Acetyltransferase involved in intracellular survival and related
A8713_RS14320	COG1490	D-aminoacyl-tRNA deacylase activity
A8713_RS14325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8713_RS14330	COG0735	belongs to the Fur family
A8713_RS14335	COG3485	protocatechuate 3,4-dioxygenase
A8713_RS14370	COG2897	thiosulfate sulfurtransferase activity
A8713_RS14395	COG0745	RESPONSE REGULATOR receiver
A8713_RS14400	COG1609	Transcriptional regulator
A8713_RS14405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8713_RS14415	COG0745	RESPONSE REGULATOR receiver
A8713_RS14430	COG0456	acetyltransferase
A8713_RS14460	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A8713_RS14480	COG1937	Protein conserved in bacteria
A8713_RS14490	COG0306	phosphate transporter
A8713_RS14495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8713_RS14520	COG0277	FAD linked oxidase domain protein
A8713_RS14525	COG0671	phosphoesterase, PA-phosphatase related
A8713_RS14530	COG1196	nuclear chromosome segregation
A8713_RS14530	COG0741	lytic transglycosylase activity
A8713_RS14530	COG0739	heme binding
A8713_RS14610	COG1252	NADH dehydrogenase
A8713_RS14640	COG0579	oxidoreductase
A8713_RS14645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8713_RS14670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8713_RS14670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8713_RS14700	COG3629	intracellular signal transduction
A8713_RS14700	COG3903	Transcriptional regulator
A8713_RS14760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8713_RS14800	COG0513	Belongs to the DEAD box helicase family
A8713_RS14835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8713_RS14875	COG1643	Atp-dependent helicase
A8713_RS14910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A8713_RS14925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8713_RS14930	COG0047	phosphoribosylformylglycinamidine synthase activity
A8713_RS14935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8713_RS14970	COG2197	response regulator
A8713_RS14980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A8713_RS14995	COG0151	Belongs to the GarS family
A8713_RS15065	COG0433	COG0433 Predicted ATPase
A8713_RS15080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8713_RS15110	COG1191	sigma factor activity
A8713_RS15115	COG1191	sigma factor activity
A8713_RS15135	COG2353	YceI-like domain
A8713_RS15150	COG3467	pyridoxamine 5'-phosphate
A8713_RS15160	COG0477	Major facilitator Superfamily
A8713_RS15165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8713_RS15175	COG2205	protein histidine kinase activity
A8713_RS15180	COG0745	RESPONSE REGULATOR receiver
A8713_RS15235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A8713_RS15255	COG0784	Response regulator, receiver
A8713_RS15260	COG1309	transcriptional regulator
A8713_RS15265	COG2814	Major facilitator Superfamily
A8713_RS15270	COG0318	PFAM AMP-dependent synthetase and ligase
A8713_RS15275	COG1595	DNA-templated transcription, initiation
A8713_RS15305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8713_RS15320	COG0653	protein targeting
A8713_RS15340	COG0006	proline dipeptidase activity
A8713_RS15345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8713_RS15365	COG1999	signal sequence binding
A8713_RS15375	COG1276	copper resistance
A8713_RS15380	COG2837	iron assimilation
A8713_RS15390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8713_RS15395	COG0561	phosphatase activity
A8713_RS15430	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A8713_RS15460	COG0561	phosphatase activity
A8713_RS15465	COG4988	ABC transporter
A8713_RS15470	COG1294	oxidase, subunit
A8713_RS15475	COG1271	oxidase subunit
A8713_RS15485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8713_RS15490	COG1609	Transcriptional regulator
A8713_RS15505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A8713_RS15530	COG0662	Cupin 2, conserved barrel domain protein
A8713_RS15535	COG1950	PFAM Membrane protein of
A8713_RS15540	COG0626	cystathionine gamma-synthase activity
A8713_RS15565	COG2814	Major facilitator Superfamily
A8713_RS15580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8713_RS15590	COG0242	peptide deformylase activity
A8713_RS15605	COG0305	Participates in initiation and elongation during chromosome replication
A8713_RS15610	COG0534	Mate efflux family protein
A8713_RS15615	COG0359	binds to the 23S rRNA
A8713_RS15620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8713_RS15625	COG0629	single-stranded DNA binding
A8713_RS15630	COG0360	Binds together with S18 to 16S ribosomal RNA
A8713_RS15655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8713_RS15665	COG1260	myo-inositol-1-phosphate synthase
A8713_RS15680	COG0617	tRNA 3'-terminal CCA addition
A8713_RS15695	COG2815	serine threonine protein kinase
A8713_RS15695	COG0515	serine threonine protein kinase
A8713_RS15700	COG1595	DNA-templated transcription, initiation
A8713_RS15710	COG0492	ferredoxin-NADP+ reductase activity
A8713_RS15715	COG3118	belongs to the thioredoxin family
A8713_RS15730	COG1192	Involved in chromosome partitioning
A8713_RS15735	COG0357	Ribosomal RNA small subunit methyltransferase G
A8713_RS15745	COG0706	membrane insertase activity
A8713_RS15750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A8713_RS15755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8713_RS15760	COG0592	DNA-directed DNA polymerase activity
A8713_RS15765	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A8713_RS15770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8713_RS15775	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A8713_RS15780	COG0187	DNA topoisomerase II activity
A8713_RS15785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8713_RS15815	COG0515	serine threonine protein kinase
A8713_RS15845	COG0318	PFAM AMP-dependent synthetase and ligase
A8713_RS15865	COG0705	Rhomboid family
A8713_RS15885	COG3764	Sortase (surface protein transpeptidase)
A8713_RS15890	COG3764	Sortase (surface protein transpeptidase)
A8713_RS15895	COG0515	serine threonine protein kinase
A8713_RS15905	COG0768	penicillin binding
A8713_RS15925	COG1716	ATPase activity
A8713_RS15930	COG1716	ATPase activity
A8713_RS15990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8713_RS15995	COG2151	metal-sulfur cluster biosynthetic enzyme
A8713_RS16000	COG3396	Phenylacetate-CoA oxygenase
A8713_RS16005	COG3460	Phenylacetate-CoA oxygenase
A8713_RS16010	COG3396	Phenylacetate-CoA oxygenase
A8713_RS16025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8713_RS16035	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8713_RS16040	COG1309	transcriptional regulator
A8713_RS16045	COG1522	sequence-specific DNA binding
A8713_RS16075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8713_RS16080	COG0604	alcohol dehydrogenase
A8713_RS16080	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS16080	COG3321	synthase
A8713_RS16095	COG0515	serine threonine protein kinase
A8713_RS16100	COG0515	serine threonine protein kinase
A8713_RS16105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8713_RS16115	COG0022	dehydrogenase e1 component
A8713_RS16120	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8713_RS16135	COG2186	Transcriptional regulator
A8713_RS16170	COG1362	aminopeptidase activity
A8713_RS16175	COG1960	acyl-CoA dehydrogenase activity
A8713_RS16185	COG1741	Belongs to the pirin family
A8713_RS16200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8713_RS16220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8713_RS16305	COG1957	nucleoside hydrolase
A8713_RS16310	COG0366	Alpha amylase catalytic
A8713_RS16360	COG1140	nitrate reductase beta subunit
A8713_RS16370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8713_RS16385	COG4585	Histidine kinase
A8713_RS16425	COG0535	radical SAM domain protein
A8713_RS16500	COG3629	intracellular signal transduction
A8713_RS16500	COG3903	Transcriptional regulator
A8713_RS16515	COG3250	beta-galactosidase activity
A8713_RS16520	COG1609	Transcriptional regulator
A8713_RS16535	COG0395	ABC-type sugar transport system, permease component
A8713_RS16545	COG1595	DNA-templated transcription, initiation
A8713_RS16560	COG0513	Belongs to the DEAD box helicase family
A8713_RS16565	COG1278	Cold shock
A8713_RS16605	COG1278	Cold shock
A8713_RS16615	COG4260	virion core protein, lumpy skin disease virus
A8713_RS16640	COG0717	Belongs to the dCTP deaminase family
A8713_RS16645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A8713_RS16665	COG2181	nitrate reductase activity
A8713_RS16665	COG0247	lactate metabolic process
A8713_RS16670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8713_RS16675	COG0443	Heat shock 70 kDa protein
A8713_RS16680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8713_RS16685	COG0484	heat shock protein binding
A8713_RS16690	COG0789	Transcriptional regulator
A8713_RS16695	COG1879	ABC-type sugar transport system periplasmic component
A8713_RS16725	COG0542	response to heat
A8713_RS16750	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A8713_RS16755	COG4585	Histidine kinase
A8713_RS16760	COG2197	response regulator
A8713_RS16775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8713_RS16780	COG0191	fructose-bisphosphate aldolase activity
A8713_RS16795	COG3844	kynureninase activity
A8713_RS16815	COG4585	Histidine kinase
A8713_RS16820	COG2197	response regulator
A8713_RS16830	COG2197	response regulator
A8713_RS16845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A8713_RS16855	COG1802	Transcriptional regulator
A8713_RS16860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8713_RS16875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A8713_RS16880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8713_RS16895	COG0697	spore germination
A8713_RS16900	COG1522	sequence-specific DNA binding
A8713_RS16905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8713_RS16920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8713_RS16940	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A8713_RS16950	COG3629	intracellular signal transduction
A8713_RS16950	COG3903	Transcriptional regulator
A8713_RS16965	COG1595	DNA-templated transcription, initiation
A8713_RS16990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS17020	COG1408	metallophosphoesterase
A8713_RS17030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A8713_RS17040	COG0003	Pfam Anion-transporting ATPase
A8713_RS17060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8713_RS17090	COG2267	carboxylic ester hydrolase activity
A8713_RS17100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8713_RS17105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8713_RS17110	COG0659	secondary active sulfate transmembrane transporter activity
A8713_RS17160	COG1205	dead DEAH box helicase
A8713_RS17160	COG1111	helicase
A8713_RS17165	COG1366	Belongs to the anti-sigma-factor antagonist family
A8713_RS17170	COG2172	sigma factor antagonist activity
A8713_RS17175	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A8713_RS17185	COG2890	protein-(glutamine-N5) methyltransferase activity
A8713_RS17195	COG1754	DNA topoisomerase type I activity
A8713_RS17195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8713_RS17200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A8713_RS17250	COG4191	Histidine kinase
A8713_RS17255	COG2201	protein-glutamate methylesterase activity
A8713_RS17275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8713_RS17285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8713_RS17285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8713_RS17325	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS17350	COG0789	Transcriptional regulator
A8713_RS17365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A8713_RS17370	COG2027	D-alanyl-D-alanine carboxypeptidase
A8713_RS17380	COG0037	tRNA processing
A8713_RS17395	COG0302	gtp cyclohydrolase
A8713_RS17410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A8713_RS17450	COG0649	NAD binding
A8713_RS17465	COG2197	response regulator
A8713_RS17490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A8713_RS17495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A8713_RS17505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A8713_RS17525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A8713_RS17555	COG0739	heme binding
A8713_RS17570	COG2205	protein histidine kinase activity
A8713_RS17575	COG0745	RESPONSE REGULATOR receiver
A8713_RS17585	COG1595	DNA-templated transcription, initiation
A8713_RS17590	COG1194	a g-specific adenine glycosylase
A8713_RS17600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A8713_RS17620	COG0248	Ppx GppA phosphatase
A8713_RS17625	COG1082	Xylose isomerase domain protein TIM barrel
A8713_RS17630	COG0129	dihydroxy-acid dehydratase activity
A8713_RS17635	COG0515	serine threonine protein kinase
A8713_RS17635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8713_RS17640	COG4991	sh3 domain protein
A8713_RS17655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8713_RS17660	COG0180	Tryptophanyl-tRNA synthetase
A8713_RS17685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8713_RS17700	COG0123	including yeast histone deacetylase and acetoin utilization protein
A8713_RS17745	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A8713_RS17750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A8713_RS17755	COG0181	hydroxymethylbilane synthase activity
A8713_RS17760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8713_RS17760	COG1648	precorrin-2 dehydrogenase activity
A8713_RS17780	COG0113	porphobilinogen synthase activity
A8713_RS17830	COG0018	arginyl-trna synthetase
A8713_RS17835	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A8713_RS17855	COG1690	Belongs to the RtcB family
A8713_RS17875	COG1742	UPF0060 membrane protein
A8713_RS17890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS17910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8713_RS17910	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A8713_RS17940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8713_RS17955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8713_RS17960	COG0406	alpha-ribazole phosphatase activity
A8713_RS17970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8713_RS17975	COG0785	Cytochrome C biogenesis protein
A8713_RS17980	COG1333	cytochrome c biogenesis protein
A8713_RS17985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8713_RS18005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8713_RS18005	COG0515	serine threonine protein kinase
A8713_RS18010	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8713_RS18040	COG0582	viral genome integration into host DNA
A8713_RS18065	COG0163	prenyltransferase activity
A8713_RS18075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A8713_RS18080	COG1573	uracil-dna glycosylase
A8713_RS18095	COG1309	transcriptional regulator
A8713_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS18110	COG0183	Belongs to the thiolase family
A8713_RS18115	COG0583	DNA-binding transcription factor activity
A8713_RS18120	COG1278	Cold shock
A8713_RS18125	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A8713_RS18135	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A8713_RS18165	COG2226	methyltransferase
A8713_RS18195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS18200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS18205	COG0649	NAD binding
A8713_RS18215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A8713_RS18220	COG1034	ATP synthesis coupled electron transport
A8713_RS18225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A8713_RS18230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS18240	COG0713	ATP synthesis coupled electron transport
A8713_RS18245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8713_RS18255	COG1007	ATP synthesis coupled electron transport
A8713_RS18260	COG0514	ATP-dependent DNA helicase (RecQ)
A8713_RS18280	COG0561	phosphatase activity
A8713_RS18290	COG0142	geranyltranstransferase activity
A8713_RS18335	COG0702	epimerase
A8713_RS18340	COG1733	regulation of RNA biosynthetic process
A8713_RS18345	COG1013	pyruvate-flavodoxin oxidoreductase activity
A8713_RS18350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A8713_RS18350	COG0674	pyruvate-flavodoxin oxidoreductase activity
A8713_RS18370	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS18375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS18380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS18385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A8713_RS18390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS18395	COG0839	Belongs to the complex I subunit 6 family
A8713_RS18400	COG0713	ATP synthesis coupled electron transport
A8713_RS18405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8713_RS18415	COG1007	ATP synthesis coupled electron transport
A8713_RS18420	COG0501	Belongs to the peptidase M48B family
A8713_RS18425	COG3304	Inner membrane component domain
A8713_RS18430	COG2261	transglycosylase associated protein
A8713_RS18435	COG1666	GTP binding
A8713_RS18485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8713_RS18490	COG2030	dehydratase
A8713_RS18500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8713_RS18520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A8713_RS18525	COG0436	Aminotransferase
A8713_RS18550	COG0081	regulation of translation
A8713_RS18565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A8713_RS18570	COG0222	ribosome binding
A8713_RS18575	COG0085	RNA polymerase activity
A8713_RS18580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A8713_RS18590	COG0463	Glycosyl transferase, family 2
A8713_RS18595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A8713_RS18600	COG0049	tRNA binding
A8713_RS18605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8713_RS18610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8713_RS18630	COG1136	(ABC) transporter
A8713_RS18640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8713_RS18685	COG0051	transcription antitermination factor activity, RNA binding
A8713_RS18690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8713_RS18695	COG0088	Forms part of the polypeptide exit tunnel
A8713_RS18700	COG0089	rRNA binding
A8713_RS18705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8713_RS18710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A8713_RS18715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A8713_RS18720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A8713_RS18725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8713_RS18730	COG0255	Belongs to the universal ribosomal protein uL29 family
A8713_RS18735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8713_RS18740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A8713_RS18745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A8713_RS18750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8713_RS18755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8713_RS18760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8713_RS18765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A8713_RS18770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8713_RS18775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8713_RS18780	COG1841	ribosomal large subunit assembly
A8713_RS18785	COG0200	Binds to the 23S rRNA
A8713_RS18795	COG0563	adenylate kinase activity
A8713_RS18805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8713_RS18810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A8713_RS18815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8713_RS18820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A8713_RS18825	COG0202	RNA polymerase activity
A8713_RS18830	COG0203	ribosomal protein L17
A8713_RS18835	COG0101	tRNA pseudouridine synthase activity
A8713_RS18840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8713_RS18855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A8713_RS18860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8713_RS18865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8713_RS18875	COG1072	(Pantothenic acid kinase))
A8713_RS18880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8713_RS18890	COG0736	holo-[acyl-carrier-protein] synthase activity
A8713_RS18905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8713_RS18910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8713_RS18915	COG0802	atpase or kinase
A8713_RS18930	COG0456	acetyltransferase
A8713_RS18930	COG1214	PFAM Peptidase M22, glycoprotease
A8713_RS18940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8713_RS18955	COG1316	TRANSCRIPTIONal
A8713_RS18970	COG1970	mechanosensitive ion channel activity
A8713_RS18980	COG0726	polysaccharide deacetylase
A8713_RS18985	COG0726	polysaccharide deacetylase
A8713_RS18990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8713_RS18995	COG0459	protein refolding
A8713_RS19025	COG4221	oxidoreductase activity
A8713_RS19035	COG0583	DNA-binding transcription factor activity
A8713_RS19050	COG1595	DNA-templated transcription, initiation
A8713_RS19060	COG0516	GMP reductase activity
A8713_RS19070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8713_RS19080	COG2815	serine threonine protein kinase
A8713_RS19080	COG0515	serine threonine protein kinase
A8713_RS19085	COG0515	serine threonine protein kinase
A8713_RS19090	COG2815	serine threonine protein kinase
A8713_RS19090	COG0515	serine threonine protein kinase
A8713_RS19095	COG0515	serine threonine protein kinase
A8713_RS19115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8713_RS19115	COG0519	Catalyzes the synthesis of GMP from XMP
A8713_RS19155	COG2197	response regulator
A8713_RS19175	COG3547	Transposase (IS116 IS110 IS902 family)
A8713_RS19195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A8713_RS19210	COG0714	Associated with various cellular activities
A8713_RS19215	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A8713_RS19220	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A8713_RS19225	COG0045	succinate-CoA ligase (ADP-forming) activity
A8713_RS19255	COG0138	bifunctional purine biosynthesis protein purh
A8713_RS19310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8713_RS19330	COG0039	L-malate dehydrogenase activity
A8713_RS19350	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS19360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8713_RS19365	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8713_RS19370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8713_RS19385	COG0754	glutathionylspermidine amidase activity
A8713_RS19390	COG0789	Transcriptional regulator
A8713_RS19400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8713_RS19405	COG0180	Tryptophanyl-tRNA synthetase
A8713_RS19420	COG1295	ribonuclease BN
A8713_RS19425	COG1686	Belongs to the peptidase S11 family
A8713_RS19450	COG0477	Major facilitator Superfamily
A8713_RS19455	COG1733	regulation of RNA biosynthetic process
A8713_RS19460	COG0778	Nitroreductase
A8713_RS19475	COG0167	dihydroorotate dehydrogenase activity
A8713_RS19485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8713_RS19495	COG0504	CTP synthase activity
A8713_RS19505	COG1053	succinate dehydrogenase
A8713_RS19515	COG2009	succinate dehydrogenase
A8713_RS19525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A8713_RS19545	COG1595	DNA-templated transcription, initiation
A8713_RS19560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A8713_RS19560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A8713_RS19575	COG1215	transferase activity, transferring glycosyl groups
A8713_RS19590	COG2089	acid synthase
A8713_RS19600	COG1473	amidohydrolase
A8713_RS19600	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A8713_RS19605	COG1744	ABC transporter substrate-binding protein PnrA-like
A8713_RS19610	COG1744	ABC transporter substrate-binding protein PnrA-like
A8713_RS19615	COG3845	ABC transporter
A8713_RS19620	COG4603	Belongs to the binding-protein-dependent transport system permease family
A8713_RS19625	COG1079	Belongs to the binding-protein-dependent transport system permease family
A8713_RS19640	COG0679	Auxin Efflux Carrier
A8713_RS19655	COG2814	Major facilitator Superfamily
A8713_RS19660	COG0583	DNA-binding transcription factor activity
A8713_RS19670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A8713_RS19695	COG2205	protein histidine kinase activity
A8713_RS19700	COG0745	RESPONSE REGULATOR receiver
A8713_RS19705	COG1595	DNA-templated transcription, initiation
A8713_RS19720	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS19725	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS19730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A8713_RS19740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8713_RS19765	COG4770	biotin carboxylase activity
A8713_RS19775	COG0424	maF-like protein
A8713_RS19785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8713_RS19795	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A8713_RS19800	COG1024	Enoyl-CoA hydratase
A8713_RS19810	COG2986	histidine ammonia-lyase
A8713_RS19830	COG1136	(ABC) transporter
A8713_RS19840	COG1064	alcohol dehydrogenase
A8713_RS19870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8713_RS19875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8713_RS19885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8713_RS19950	COG1518	maintenance of DNA repeat elements
A8713_RS19965	COG1857	crispr-associated protein
A8713_RS19990	COG1331	Highly conserved protein containing a thioredoxin domain
A8713_RS20000	COG1309	transcriptional regulator
A8713_RS20010	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A8713_RS20025	COG0436	Aminotransferase
A8713_RS20035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A8713_RS20050	COG1414	Transcriptional regulator
A8713_RS20060	COG2610	gluconate transmembrane transporter activity
A8713_RS20095	COG2894	cell division
A8713_RS20125	COG3920	Histidine kinase
A8713_RS20150	COG2885	chlorophyll binding
A8713_RS20160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A8713_RS20175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8713_RS20180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A8713_RS20200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8713_RS20205	COG0450	alkyl hydroperoxide reductase
A8713_RS20220	COG1136	(ABC) transporter
A8713_RS20240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8713_RS20255	COG0114	fumarate hydratase activity
A8713_RS20260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A8713_RS20260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A8713_RS20285	COG1722	exodeoxyribonuclease VII activity
A8713_RS20290	COG1570	exodeoxyribonuclease VII activity
A8713_RS20295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A8713_RS20310	COG0012	GTP binding
A8713_RS20345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8713_RS20355	COG3629	intracellular signal transduction
A8713_RS20355	COG3903	Transcriptional regulator
A8713_RS20375	COG0133	tryptophan synthase activity
A8713_RS20385	COG0534	Mate efflux family protein
A8713_RS20480	COG1217	gtp-binding protein TYPA
A8713_RS20495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8713_RS20505	COG4608	Belongs to the ABC transporter superfamily
A8713_RS20515	COG0601	transmembrane transport
A8713_RS20520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8713_RS20530	COG4608	Belongs to the ABC transporter superfamily
A8713_RS20590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8713_RS20605	COG1131	(ABC) transporter
A8713_RS20615	COG4585	Histidine kinase
A8713_RS20620	COG2197	response regulator
A8713_RS20655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8713_RS20665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8713_RS20675	COG0519	Catalyzes the synthesis of GMP from XMP
A8713_RS20680	COG1024	Enoyl-CoA hydratase
A8713_RS20695	COG1595	DNA-templated transcription, initiation
A8713_RS20705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8713_RS20710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8713_RS20745	COG0598	Magnesium transport protein CorA
A8713_RS20755	COG2814	Major facilitator Superfamily
A8713_RS20770	COG2095	MarC family integral membrane protein
A8713_RS20775	COG1432	Conserved Protein
A8713_RS20830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8713_RS20835	COG0601	transmembrane transport
A8713_RS20900	COG0210	DNA helicase
A8713_RS20905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8713_RS20910	COG2816	NAD+ diphosphatase activity
A8713_RS20945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A8713_RS20995	COG3480	Lon protease (S16) C-terminal proteolytic domain
A8713_RS21005	COG1615	UPF0182 protein
A8713_RS21025	COG0753	catalase activity
A8713_RS21035	COG0483	inositol monophosphate 1-phosphatase activity
A8713_RS21045	COG2076	Multidrug Resistance protein
A8713_RS21055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8713_RS21065	COG2135	peptidase activity
A8713_RS21075	COG1595	DNA-templated transcription, initiation
A8713_RS21080	COG5662	AntiSigma factor
A8713_RS21085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A8713_RS21085	COG2199	diguanylate cyclase activity
A8713_RS21100	COG0242	peptide deformylase activity
A8713_RS21110	COG2124	cytochrome p450
A8713_RS21125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A8713_RS21125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8713_RS21140	COG2188	Transcriptional regulator
A8713_RS21145	COG2182	Extracellular solute-binding protein
A8713_RS21150	COG1175	transmembrane transport
A8713_RS21155	COG0395	ABC-type sugar transport system, permease component
A8713_RS21160	COG1472	Belongs to the glycosyl hydrolase 3 family
A8713_RS21165	COG0363	glucosamine-6-phosphate deaminase activity
A8713_RS21170	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS21190	COG1597	lipid kinase activity
A8713_RS21205	COG2172	sigma factor antagonist activity
A8713_RS21225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8713_RS21230	COG0142	geranyltranstransferase activity
A8713_RS21275	COG1595	DNA-templated transcription, initiation
A8713_RS21305	COG4106	trans-aconitate 2-methyltransferase activity
A8713_RS21325	COG0281	malic enzyme
A8713_RS21330	COG0604	alcohol dehydrogenase
A8713_RS21360	COG0567	Dehydrogenase, E1 component
A8713_RS21360	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8713_RS21365	COG2205	protein histidine kinase activity
A8713_RS21370	COG0745	RESPONSE REGULATOR receiver
A8713_RS21395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A8713_RS21450	COG1309	transcriptional regulator
A8713_RS21475	COG2205	protein histidine kinase activity
A8713_RS21495	COG1793	dna ligase
A8713_RS21495	COG3285	dna ligase
A8713_RS21500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A8713_RS21520	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A8713_RS21555	COG0745	RESPONSE REGULATOR receiver
A8713_RS21560	COG0018	arginyl-trna synthetase
A8713_RS21560	COG0018	arginyl-trna synthetase
A8713_RS21565	COG0019	diaminopimelate decarboxylase activity
A8713_RS21570	COG0460	homoserine dehydrogenase
A8713_RS21575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A8713_RS21580	COG0083	homoserine kinase activity
A8713_RS21595	COG0254	rRNA binding
A8713_RS21600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8713_RS21605	COG2890	protein-(glutamine-N5) methyltransferase activity
A8713_RS21615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8713_RS21620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8713_RS21625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8713_RS21640	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8713_RS21645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8713_RS21650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8713_RS21655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8713_RS21660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8713_RS21665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A8713_RS21670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8713_RS21685	COG2197	response regulator
A8713_RS21720	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8713_RS21735	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A8713_RS21770	COG1131	(ABC) transporter
A8713_RS21790	COG0183	Belongs to the thiolase family
A8713_RS21850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A8713_RS21850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A8713_RS21885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8713_RS21890	COG0280	phosphate acetyltransferase
A8713_RS21890	COG0857	belongs to the CobB CobQ family
A8713_RS21895	COG0205	6-phosphofructokinase activity
A8713_RS21905	COG4565	transcriptional regulatory protein
A8713_RS21915	COG1301	dicarboxylic acid transport
A8713_RS21925	COG0477	Major facilitator Superfamily
A8713_RS21940	COG3118	belongs to the thioredoxin family
A8713_RS21950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8713_RS21960	COG3281	Trehalose synthase
A8713_RS21970	COG0366	Alpha amylase catalytic
A8713_RS21975	COG0058	SHG alpha-glucan phosphorylase activity
A8713_RS22020	COG1132	(ABC) transporter
A8713_RS22025	COG1132	(ABC) transporter
A8713_RS22030	COG2197	response regulator
A8713_RS22035	COG4585	Histidine kinase
A8713_RS22050	COG1132	(ABC) transporter
A8713_RS22055	COG1132	(ABC) transporter
A8713_RS22060	COG1131	(ABC) transporter
A8713_RS22070	COG4585	Histidine kinase
A8713_RS22075	COG2197	response regulator
A8713_RS22085	COG1376	ErfK ybiS ycfS ynhG family protein
A8713_RS22090	COG1376	ErfK ybiS ycfS ynhG family protein
A8713_RS22120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8713_RS22125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8713_RS22130	COG2085	NADP oxidoreductase coenzyme F420-dependent
A8713_RS22145	COG1760	l-serine dehydratase
A8713_RS22150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8713_RS22155	COG0509	glycine decarboxylation via glycine cleavage system
A8713_RS22160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8713_RS22180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8713_RS22195	COG0444	Belongs to the ABC transporter superfamily
A8713_RS22200	COG4608	Belongs to the ABC transporter superfamily
A8713_RS22205	COG0308	aminopeptidase N
A8713_RS22210	COG2860	membrane
A8713_RS22230	COG1309	transcriptional regulator
A8713_RS22250	COG0482	sulfurtransferase activity
A8713_RS22265	COG1611	Belongs to the LOG family
A8713_RS22270	COG4221	oxidoreductase activity
A8713_RS22280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8713_RS22300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8713_RS22305	COG0154	amidase activity
A8713_RS22315	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8713_RS22325	COG2409	Drug exporters of the RND superfamily
A8713_RS22330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8713_RS22345	COG2197	response regulator
A8713_RS22355	COG2133	pyrroloquinoline quinone binding
A8713_RS22360	COG0667	Aldo Keto reductase
A8713_RS22380	COG0440	acetolactate synthase activity
A8713_RS22385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8713_RS22390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8713_RS22395	COG0477	Major facilitator Superfamily
A8713_RS22405	COG3835	regulator
A8713_RS22410	COG0506	proline dehydrogenase activity
A8713_RS22415	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS22430	COG0473	3-isopropylmalate dehydrogenase activity
A8713_RS22435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8713_RS22440	COG0831	urea catabolic process
A8713_RS22440	COG0832	Belongs to the urease beta subunit family
A8713_RS22445	COG0804	urea catabolic process
A8713_RS22450	COG2957	Belongs to the agmatine deiminase family
A8713_RS22485	COG0477	Major facilitator Superfamily
A8713_RS22490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8713_RS22540	COG5492	domain, Protein
A8713_RS22545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8713_RS22565	COG2018	Roadblock/LC7 domain
A8713_RS22585	COG2018	Roadblock/LC7 domain
A8713_RS22590	COG5002	protein histidine kinase activity
A8713_RS22600	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8713_RS22605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8713_RS22650	COG1414	Transcriptional regulator
A8713_RS22655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8713_RS22660	COG0066	3-isopropylmalate dehydratase activity
A8713_RS22670	COG0776	regulation of translation
A8713_RS22680	COG1920	GTP binding
A8713_RS22690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8713_RS22695	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8713_RS22715	COG0351	phosphomethylpyrimidine kinase
A8713_RS22725	COG3903	Transcriptional regulator
A8713_RS22725	COG3629	intracellular signal transduction
A8713_RS22735	COG1461	Dihydroxyacetone kinase
A8713_RS22745	COG0742	ribosomal rna small subunit methyltransferase
A8713_RS22750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8713_RS22765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8713_RS22770	COG0571	ribonuclease III activity
A8713_RS22775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8713_RS22780	COG1733	regulation of RNA biosynthetic process
A8713_RS22790	COG1254	Belongs to the acylphosphatase family
A8713_RS22805	COG0477	Major facilitator Superfamily
A8713_RS22810	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A8713_RS22845	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A8713_RS22855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8713_RS22870	COG0228	four-way junction DNA binding
A8713_RS22875	COG1837	Belongs to the UPF0109 family
A8713_RS22880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A8713_RS22885	COG0336	Belongs to the RNA methyltransferase TrmD family
A8713_RS22890	COG0335	large ribosomal subunit rRNA binding
A8713_RS22895	COG0681	Belongs to the peptidase S26 family
A8713_RS22905	COG0681	Belongs to the peptidase S26 family
A8713_RS22915	COG1051	belongs to the nudix hydrolase family
A8713_RS22925	COG0792	nuclease activity
A8713_RS22940	COG1191	sigma factor activity
A8713_RS22950	COG3547	Transposase (IS116 IS110 IS902 family)
A8713_RS22960	COG0052	Belongs to the universal ribosomal protein uS2 family
A8713_RS22970	COG0528	UMP kinase activity
A8713_RS22975	COG0233	cytoplasmic translational termination
A8713_RS22980	COG0575	Belongs to the CDS family
A8713_RS22985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A8713_RS22995	COG4208	sulfate ABC transporter
A8713_RS23000	COG3842	ATPase activity
A8713_RS23020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8713_RS23030	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS23130	COG0464	growth
A8713_RS23140	COG2197	response regulator
A8713_RS23160	COG0584	glycerophosphoryl diester phosphodiesterase
A8713_RS23165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A8713_RS23195	COG3842	ATPase activity
A8713_RS23200	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8713_RS23205	COG1177	transmembrane transport
A8713_RS23210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8713_RS23240	COG2508	Transcriptional regulator
A8713_RS23245	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS23255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A8713_RS23260	COG0750	zinc metalloprotease
A8713_RS23265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A8713_RS23285	COG0442	prolyl-tRNA aminoacylation
A8713_RS23290	COG0038	chloride channel
A8713_RS23310	COG0779	Required for maturation of 30S ribosomal subunits
A8713_RS23325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8713_RS23335	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8713_RS23340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8713_RS23365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8713_RS23370	COG0601	transmembrane transport
A8713_RS23380	COG0455	bacterial-type flagellum organization
A8713_RS23450	COG1674	ftsk spoiiie
A8713_RS23470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A8713_RS23475	COG1185	polyribonucleotide nucleotidyltransferase activity
A8713_RS23480	COG0612	Peptidase, M16
A8713_RS23485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A8713_RS23505	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A8713_RS23510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8713_RS23515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A8713_RS23550	COG2208	phosphoserine phosphatase activity
A8713_RS23550	COG2770	Histidine kinase
A8713_RS23555	COG4999	Histidine kinase
A8713_RS23555	COG3437	response regulator, receiver
A8713_RS23555	COG2205	protein histidine kinase activity
A8713_RS23555	COG3850	Histidine kinase
A8713_RS23565	COG1674	ftsk spoiiie
A8713_RS23575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8713_RS23585	COG1546	Belongs to the CinA family
A8713_RS23585	COG1058	Belongs to the CinA family
A8713_RS23590	COG1396	sequence-specific DNA binding
A8713_RS23600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8713_RS23605	COG1201	RNA secondary structure unwinding
A8713_RS23635	COG0628	permease
A8713_RS23690	COG0765	amino acid transport
A8713_RS23695	COG0765	amino acid transport
A8713_RS23700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8713_RS23705	COG1126	abc transporter atp-binding protein
A8713_RS23710	COG0745	RESPONSE REGULATOR receiver
A8713_RS23715	COG2205	protein histidine kinase activity
A8713_RS23720	COG2358	TRAP transporter, solute receptor (TAXI family
A8713_RS23735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8713_RS23755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A8713_RS23765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8713_RS23770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8713_RS23780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8713_RS23825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A8713_RS23830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A8713_RS23835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8713_RS23850	COG0588	phosphoglycerate mutase activity
A8713_RS23860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8713_RS23875	COG0514	ATP-dependent DNA helicase (RecQ)
A8713_RS23900	COG2186	Transcriptional regulator
A8713_RS23905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8713_RS23920	COG0187	DNA topoisomerase II activity
A8713_RS23935	COG2197	response regulator
A8713_RS23945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8713_RS23950	COG4565	transcriptional regulatory protein
A8713_RS23960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8713_RS23970	COG3290	protein histidine kinase activity
A8713_RS23980	COG0300	oxidoreductase activity
A8713_RS24000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8713_RS24005	COG3320	Male sterility
A8713_RS24005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8713_RS24015	COG1132	(ABC) transporter
A8713_RS24020	COG1132	(ABC) transporter
A8713_RS24020	COG2375	cellular response to nickel ion
A8713_RS24025	COG2409	Drug exporters of the RND superfamily
A8713_RS24040	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A8713_RS24050	COG1535	isochorismatase
A8713_RS24050	COG3433	isochorismatase activity
A8713_RS24055	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS24060	COG0402	S-adenosylhomocysteine deaminase activity
A8713_RS24070	COG1021	2,3-dihydroxybenzoate-AMP ligase
A8713_RS24075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8713_RS24095	COG0477	Major facilitator Superfamily
A8713_RS24100	COG3903	Transcriptional regulator
A8713_RS24100	COG3629	intracellular signal transduction
A8713_RS24110	COG3321	synthase
A8713_RS24110	COG0604	alcohol dehydrogenase
A8713_RS24120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8713_RS24120	COG2070	2-Nitropropane dioxygenase
A8713_RS24130	COG1960	acyl-CoA dehydrogenase activity
A8713_RS24145	COG3629	intracellular signal transduction
A8713_RS24145	COG3903	Transcriptional regulator
A8713_RS24160	COG1169	isochorismate synthase
A8713_RS24165	COG1021	2,3-dihydroxybenzoate-AMP ligase
A8713_RS24170	COG1535	isochorismatase
A8713_RS24170	COG3433	isochorismatase activity
A8713_RS24175	COG1535	isochorismatase
A8713_RS24175	COG3433	isochorismatase activity
A8713_RS24180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8713_RS24200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8713_RS24205	COG0612	Peptidase, M16
A8713_RS24220	COG1802	Transcriptional regulator
A8713_RS24225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8713_RS24240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A8713_RS24245	COG1435	thymidine kinase activity
A8713_RS24255	COG0831	urea catabolic process
A8713_RS24265	COG0832	Belongs to the urease beta subunit family
A8713_RS24275	COG0830	nickel cation binding
A8713_RS24280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A8713_RS24285	COG0829	nickel cation binding
A8713_RS24315	COG3864	Putative metallopeptidase domain
A8713_RS24360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8713_RS24370	COG0745	RESPONSE REGULATOR receiver
A8713_RS24375	COG2205	protein histidine kinase activity
A8713_RS24400	COG0756	dUTP diphosphatase activity
A8713_RS24410	COG1136	(ABC) transporter
A8713_RS24440	COG0569	domain protein
A8713_RS24445	COG0531	amino acid
A8713_RS24450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8713_RS24470	COG0477	Major facilitator Superfamily
A8713_RS24490	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
A8713_RS24500	COG0583	DNA-binding transcription factor activity
A8713_RS24505	COG1414	Transcriptional regulator
A8713_RS24510	COG3971	2-oxopent-4-enoate hydratase activity
A8713_RS24515	COG4569	acetaldehyde dehydrogenase (acetylating) activity
A8713_RS24520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8713_RS24530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8713_RS24545	COG1215	transferase activity, transferring glycosyl groups
A8713_RS24555	COG4310	Domain of unknown function (DUF2172)
A8713_RS24570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8713_RS24625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8713_RS24635	COG0275	rRNA processing
A8713_RS24675	COG3629	intracellular signal transduction
A8713_RS24675	COG3903	Transcriptional regulator
A8713_RS24700	COG1024	Enoyl-CoA hydratase
A8713_RS24700	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8713_RS24735	COG1396	sequence-specific DNA binding
A8713_RS24735	COG3800	Transcriptional regulator
A8713_RS24745	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A8713_RS24765	COG2261	transglycosylase associated protein
A8713_RS24770	COG0640	Transcriptional regulator
A8713_RS24775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A8713_RS24800	COG1127	ABC transporter
A8713_RS24810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A8713_RS24880	COG2205	protein histidine kinase activity
A8713_RS24885	COG0745	RESPONSE REGULATOR receiver
A8713_RS24900	COG3973	AAA domain
A8713_RS24905	COG1799	cell septum assembly
A8713_RS24930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8713_RS24935	COG2235	arginine
A8713_RS24940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A8713_RS24950	COG1024	Enoyl-CoA hydratase
A8713_RS24985	COG0189	ligase activity
A8713_RS25015	COG0583	DNA-binding transcription factor activity
A8713_RS25025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8713_RS25030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8713_RS25035	COG3537	Alpha-1,2-mannosidase
A8713_RS25045	COG1653	transport
A8713_RS25050	COG1175	transmembrane transport
A8713_RS25055	COG0395	ABC-type sugar transport system, permease component
A8713_RS25060	COG1940	carbohydrate kinase activity
A8713_RS25065	COG4213	ABC transporter substrate-binding protein
A8713_RS25075	COG4214	carbohydrate transport
A8713_RS25080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8713_RS25085	COG0531	amino acid
A8713_RS25095	COG1024	Enoyl-CoA hydratase
A8713_RS25095	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8713_RS25100	COG0183	Belongs to the thiolase family
A8713_RS25105	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A8713_RS25120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8713_RS25135	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8713_RS25145	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A8713_RS25150	COG3253	May function as heme-dependent peroxidase
A8713_RS25165	COG3220	belongs to the UPF0276 family
A8713_RS25185	COG0723	plastoquinol--plastocyanin reductase activity
A8713_RS25185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8713_RS25190	COG0330	HflC and HflK could
A8713_RS25210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8713_RS25215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8713_RS25235	COG1174	glycine betaine transport
A8713_RS25250	COG2018	Roadblock/LC7 domain
A8713_RS25255	COG5002	protein histidine kinase activity
A8713_RS25260	COG1732	Glycine betaine
A8713_RS25265	COG2986	histidine ammonia-lyase
A8713_RS25275	COG1309	transcriptional regulator
A8713_RS25300	COG3173	Aminoglycoside phosphotransferase
A8713_RS25375	COG2409	Drug exporters of the RND superfamily
A8713_RS25390	COG0656	L-ascorbic acid biosynthetic process
A8713_RS25395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8713_RS25400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8713_RS25420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8713_RS25425	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A8713_RS25445	COG0529	Catalyzes the synthesis of activated sulfate
A8713_RS25450	COG0175	sulfate reduction
A8713_RS25460	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8713_RS25475	COG1960	acyl-CoA dehydrogenase activity
A8713_RS25490	COG1917	Cupin 2, conserved barrel domain protein
A8713_RS25490	COG4977	sequence-specific DNA binding
A8713_RS25505	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A8713_RS25520	COG2040	homocysteine
A8713_RS25545	COG0596	Alpha beta hydrolase
A8713_RS25550	COG1309	transcriptional regulator
A8713_RS25625	COG1162	GTPase activity
A8713_RS25635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8713_RS25655	COG0028	Belongs to the TPP enzyme family
A8713_RS25700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8713_RS25705	COG2252	PERMEase
A8713_RS25720	COG0583	DNA-binding transcription factor activity
A8713_RS25735	COG0726	polysaccharide deacetylase
A8713_RS25745	COG2192	nodulation
A8713_RS25755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A8713_RS25760	COG0859	PFAM glycosyl transferase family 9
A8713_RS25770	COG0297	glycogen (starch) synthase activity
A8713_RS25775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A8713_RS25780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8713_RS25780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A8713_RS25815	COG1285	pathogenesis
A8713_RS25840	COG2197	response regulator
A8713_RS25845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8713_RS25850	COG0318	PFAM AMP-dependent synthetase and ligase
A8713_RS25870	COG3960	tartronate-semialdehyde synthase activity
A8713_RS25875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8713_RS25905	COG0753	catalase activity
A8713_RS25910	COG2084	Dehydrogenase
A8713_RS25915	COG3622	Belongs to the hyi family
A8713_RS25935	COG2351	hydroxyisourate hydrolase activity
A8713_RS25945	COG2233	PERMEase
A8713_RS25955	COG2233	PERMEase
A8713_RS25970	COG0406	alpha-ribazole phosphatase activity
A8713_RS25980	COG0436	Aminotransferase
A8713_RS25995	COG2304	oxidoreductase activity
A8713_RS26000	COG0494	nUDIX hydrolase
A8713_RS26010	COG4264	IucA IucC family
A8713_RS26035	COG0789	Transcriptional regulator
A8713_RS26045	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A8713_RS26050	COG0746	molybdenum cofactor guanylyltransferase activity
A8713_RS26060	COG2197	response regulator
A8713_RS26065	COG4585	Histidine kinase
A8713_RS26070	COG0577	efflux transmembrane transporter activity
A8713_RS26080	COG1414	Transcriptional regulator
A8713_RS26085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8713_RS26090	COG4266	Belongs to the allantoicase family
A8713_RS26095	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS26115	COG2197	response regulator
A8713_RS26125	COG0673	inositol 2-dehydrogenase activity
A8713_RS26130	COG2188	Transcriptional regulator
A8713_RS26150	COG1940	carbohydrate kinase activity
A8713_RS26160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8713_RS26180	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A8713_RS26190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8713_RS26195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A8713_RS26215	COG0405	Gamma-glutamyltransferase
A8713_RS26220	COG0542	response to heat
A8713_RS26235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8713_RS26250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8713_RS26260	COG1953	Uracil, thiamine, allantoin
A8713_RS26270	COG0095	Lipoate-protein ligase
A8713_RS26300	COG0483	inositol monophosphate 1-phosphatase activity
A8713_RS26310	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A8713_RS26330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A8713_RS26335	COG0494	nUDIX hydrolase
A8713_RS26340	COG1929	Belongs to the glycerate kinase type-1 family
A8713_RS26350	COG0688	phosphatidylethanolamine metabolic process
A8713_RS26355	COG1960	acyl-CoA dehydrogenase activity
A8713_RS26365	COG2301	Belongs to the HpcH HpaI aldolase family
A8713_RS26370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A8713_RS26370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A8713_RS26385	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8713_RS26425	COG0463	Glycosyl transferase, family 2
A8713_RS26425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8713_RS26430	COG0438	transferase activity, transferring glycosyl groups
A8713_RS26435	COG0076	glutamate decarboxylase activity
A8713_RS26450	COG2362	D-Aminopeptidase
A8713_RS26455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8713_RS26460	COG0823	Involved in the tonB-independent uptake of proteins
A8713_RS26460	COG4946	Tricorn protease homolog
A8713_RS26460	COG1506	peptidase
A8713_RS26465	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8713_RS26490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS26575	COG0488	(ABC) transporter
A8713_RS26640	COG0443	Heat shock 70 kDa protein
A8713_RS26660	COG2154	pterin-4-alpha-carbinolamine dehydratase
A8713_RS26670	COG5297	Belongs to the glycosyl hydrolase family 6
A8713_RS26685	COG0656	L-ascorbic acid biosynthetic process
A8713_RS26695	COG0477	Major facilitator Superfamily
A8713_RS26705	COG0583	DNA-binding transcription factor activity
A8713_RS26725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A8713_RS26730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8713_RS26780	COG1309	transcriptional regulator
A8713_RS26785	COG1595	DNA-templated transcription, initiation
A8713_RS26810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8713_RS26815	COG2182	Extracellular solute-binding protein
A8713_RS26820	COG1175	transmembrane transport
A8713_RS26825	COG0395	ABC-type sugar transport system, permease component
A8713_RS26830	COG2723	6-phospho-beta-galactosidase activity
A8713_RS26845	COG0747	negative chemotaxis
A8713_RS26860	COG0477	Major facilitator Superfamily
A8713_RS26870	COG3467	pyridoxamine 5'-phosphate
A8713_RS26885	COG0406	alpha-ribazole phosphatase activity
A8713_RS26890	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A8713_RS26895	COG0166	Belongs to the GPI family
A8713_RS26910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8713_RS26935	COG1486	melibiose metabolic process
A8713_RS26940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8713_RS26965	COG3842	ATPase activity
A8713_RS26970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A8713_RS26975	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8713_RS26980	COG1177	transmembrane transport
A8713_RS26995	COG1175	transmembrane transport
A8713_RS27005	COG0395	ABC-type sugar transport system, permease component
A8713_RS27010	COG0366	Alpha amylase catalytic
A8713_RS27060	COG3511	phospholipase C
A8713_RS27090	COG1672	PFAM Archaeal ATPase
A8713_RS27090	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A8713_RS27095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8713_RS27100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8713_RS27105	COG3485	protocatechuate 3,4-dioxygenase
A8713_RS27110	COG3485	protocatechuate 3,4-dioxygenase
A8713_RS27140	COG1793	dna ligase
A8713_RS27180	COG0488	(ABC) transporter
A8713_RS27210	COG1515	deoxyribonuclease V activity
A8713_RS27215	COG3268	Saccharopine dehydrogenase
A8713_RS27220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8713_RS27225	COG0183	Belongs to the thiolase family
A8713_RS27230	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8713_RS27230	COG1024	Enoyl-CoA hydratase
A8713_RS27240	COG1113	amino acid transport
A8713_RS27255	COG2936	dipeptidyl-peptidase activity
A8713_RS27265	COG0488	(ABC) transporter
A8713_RS27275	COG2183	response to ionizing radiation
A8713_RS27280	COG4977	sequence-specific DNA binding
A8713_RS27290	COG1024	Enoyl-CoA hydratase
A8713_RS27300	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A8713_RS27340	COG1562	ergosterol biosynthetic process
A8713_RS27350	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A8713_RS27360	COG1657	PFAM Prenyltransferase squalene oxidase
A8713_RS27380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8713_RS27400	COG2365	Tyrosine phosphatase family
A8713_RS27425	COG0789	Transcriptional regulator
A8713_RS27460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A8713_RS27470	COG0148	phosphopyruvate hydratase activity
A8713_RS27490	COG3979	chitinase
A8713_RS27500	COG0531	amino acid
A8713_RS27540	COG1063	alcohol dehydrogenase
A8713_RS27545	COG0156	8-amino-7-oxononanoate synthase activity
A8713_RS27550	COG0583	DNA-binding transcription factor activity
A8713_RS27565	COG3958	Transketolase
A8713_RS27570	COG3959	Transketolase, thiamine diphosphate binding domain
A8713_RS27620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8713_RS27625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8713_RS27630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8713_RS27635	COG0254	rRNA binding
A8713_RS27645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8713_RS27690	COG0583	DNA-binding transcription factor activity
A8713_RS27705	COG0590	tRNA wobble adenosine to inosine editing
A8713_RS27720	COG0666	response to abiotic stimulus
A8713_RS27735	COG2197	response regulator
A8713_RS27760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8713_RS27770	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A8713_RS27790	COG0561	phosphatase activity
A8713_RS27805	COG2267	carboxylic ester hydrolase activity
A8713_RS27815	COG0318	PFAM AMP-dependent synthetase and ligase
A8713_RS27830	COG2815	serine threonine protein kinase
A8713_RS27830	COG0515	serine threonine protein kinase
A8713_RS27835	COG0698	ribose 5-phosphate isomerase
A8713_RS27845	COG0300	oxidoreductase activity
A8713_RS27850	COG0726	polysaccharide deacetylase
A8713_RS27870	COG0477	Major facilitator Superfamily
A8713_RS27880	COG0659	secondary active sulfate transmembrane transporter activity
A8713_RS27900	COG3291	Pkd domain containing protein
A8713_RS27905	COG1802	Transcriptional regulator
A8713_RS27925	COG0301	tRNA thio-modification
A8713_RS27935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8713_RS27950	COG3962	Belongs to the TPP enzyme family
A8713_RS27955	COG3718	enzyme involved in inositol metabolism
A8713_RS27990	COG1846	Transcriptional regulator
A8713_RS28030	COG1674	ftsk spoiiie
A8713_RS28035	COG1674	ftsk spoiiie
A8713_RS28080	COG0477	Major facilitator Superfamily
A8713_RS28095	COG1733	regulation of RNA biosynthetic process
A8713_RS28120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS28125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS28130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS28135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS28160	COG2124	cytochrome p450
A8713_RS28170	COG2838	Isocitrate dehydrogenase
A8713_RS28175	COG0668	transmembrane transport
A8713_RS28180	COG1132	(ABC) transporter
A8713_RS28185	COG1584	GPR1 FUN34 yaaH family protein
A8713_RS28210	COG2837	iron assimilation
A8713_RS28220	COG0243	molybdopterin cofactor binding
A8713_RS28225	COG1289	transmembrane transporter activity
A8713_RS28245	COG0513	Belongs to the DEAD box helicase family
A8713_RS28260	COG0156	8-amino-7-oxononanoate synthase activity
A8713_RS28275	COG3321	synthase
A8713_RS28275	COG0604	alcohol dehydrogenase
A8713_RS28285	COG3321	synthase
A8713_RS28285	COG0604	alcohol dehydrogenase
A8713_RS28290	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8713_RS28315	COG3903	Transcriptional regulator
A8713_RS28315	COG3629	intracellular signal transduction
A8713_RS28350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A8713_RS28365	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8713_RS28385	COG0297	glycogen (starch) synthase activity
A8713_RS28390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8713_RS28395	COG3537	Alpha-1,2-mannosidase
A8713_RS28425	COG0778	Nitroreductase
A8713_RS28435	COG2268	Band 7 protein
A8713_RS28440	COG1609	Transcriptional regulator
A8713_RS28445	COG1653	transport
A8713_RS28450	COG1175	transmembrane transport
A8713_RS28455	COG0395	ABC-type sugar transport system, permease component
A8713_RS28475	COG2188	Transcriptional regulator
A8713_RS28480	COG1879	ABC-type sugar transport system periplasmic component
A8713_RS28485	COG1129	ABC transporter
A8713_RS28490	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8713_RS28495	COG4948	Mandelate Racemase Muconate Lactonizing
A8713_RS28500	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS28515	COG3618	amidohydrolase
A8713_RS28530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8713_RS28550	COG0531	amino acid
A8713_RS28560	COG0726	polysaccharide deacetylase
A8713_RS28600	COG0583	DNA-binding transcription factor activity
A8713_RS28610	COG0583	DNA-binding transcription factor activity
A8713_RS28620	COG1053	succinate dehydrogenase
A8713_RS28625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8713_RS28650	COG0069	glutamate synthase activity
A8713_RS28655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8713_RS28670	COG3360	Dodecin
A8713_RS28675	COG2182	Extracellular solute-binding protein
A8713_RS28680	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A8713_RS28690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A8713_RS28695	COG3572	ergothioneine biosynthetic process
A8713_RS28750	COG1609	Transcriptional regulator
A8713_RS28755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8713_RS28760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8713_RS28765	COG0242	peptide deformylase activity
A8713_RS28790	COG1012	belongs to the aldehyde dehydrogenase family
A8713_RS28795	COG2814	Major facilitator Superfamily
A8713_RS28850	COG0366	Alpha amylase catalytic
A8713_RS28855	COG3281	Trehalose synthase
A8713_RS28860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8713_RS28875	COG0297	glycogen (starch) synthase activity
A8713_RS28915	COG0702	epimerase
A8713_RS28920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8713_RS28935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS28940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A8713_RS28960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8713_RS28975	COG2382	esterase
A8713_RS28985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8713_RS28990	COG1535	isochorismatase
A8713_RS28990	COG3433	isochorismatase activity
A8713_RS28995	COG3433	isochorismatase activity
A8713_RS28995	COG1535	isochorismatase
A8713_RS29000	COG1021	2,3-dihydroxybenzoate-AMP ligase
A8713_RS29005	COG1169	isochorismate synthase
A8713_RS29010	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS29015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8713_RS29020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS29025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS29030	COG1120	ATPase activity
A8713_RS29040	COG3336	cytochrome c oxidase
A8713_RS29050	COG0577	efflux transmembrane transporter activity
A8713_RS29055	COG1136	(ABC) transporter
A8713_RS29060	COG0247	lactate metabolic process
A8713_RS29060	COG0277	FAD linked oxidase domain protein
A8713_RS29065	COG0028	Belongs to the TPP enzyme family
A8713_RS29075	COG0300	oxidoreductase activity
A8713_RS29095	COG0577	efflux transmembrane transporter activity
A8713_RS29095	COG1136	(ABC) transporter
A8713_RS29100	COG1174	glycine betaine transport
A8713_RS29105	COG1174	glycine betaine transport
A8713_RS29120	COG1556	Lactate utilization protein
A8713_RS29125	COG1139	Iron-sulfur cluster binding protein
A8713_RS29130	COG0247	lactate metabolic process
A8713_RS29140	COG1595	DNA-templated transcription, initiation
A8713_RS29150	COG1357	PFAM Pentapeptide repeats (8 copies)
A8713_RS29160	COG1309	transcriptional regulator
A8713_RS29170	COG2706	6-phosphogluconolactonase activity
A8713_RS29255	COG1796	DNA polymerase
A8713_RS29255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8713_RS29290	COG2111	Na H antiporter
A8713_RS29295	COG1006	Multisubunit Na H antiporter MnhC subunit
A8713_RS29300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8713_RS29305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8713_RS29310	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A8713_RS29320	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS29325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS29340	COG1132	(ABC) transporter
A8713_RS29350	COG0435	Glutathione S-transferase
A8713_RS29365	COG2124	cytochrome p450
A8713_RS29380	COG0667	Aldo Keto reductase
A8713_RS29405	COG1595	DNA-templated transcription, initiation
A8713_RS29440	COG2890	protein-(glutamine-N5) methyltransferase activity
A8713_RS29455	COG0248	Ppx GppA phosphatase
A8713_RS29470	COG1132	(ABC) transporter
A8713_RS29475	COG1132	(ABC) transporter
A8713_RS29485	COG0515	serine threonine protein kinase
A8713_RS29505	COG1335	isochorismatase
A8713_RS29510	COG0477	Major facilitator Superfamily
A8713_RS29530	COG3608	succinylglutamate desuccinylase aspartoacylase
A8713_RS29530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A8713_RS29565	COG0789	Transcriptional regulator
A8713_RS29570	COG1819	glycosyl
A8713_RS29580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8713_RS29610	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS29645	COG1051	belongs to the nudix hydrolase family
A8713_RS29705	COG0671	phosphoesterase, PA-phosphatase related
A8713_RS29710	COG0586	Pfam SNARE associated Golgi protein
A8713_RS29715	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A8713_RS29735	COG3387	PFAM Glycoside hydrolase 15-related
A8713_RS29745	COG3290	protein histidine kinase activity
A8713_RS29760	COG0477	Major facilitator Superfamily
A8713_RS29765	COG3001	Fructosamine kinase
A8713_RS29795	COG0277	FAD linked oxidase domain protein
A8713_RS29800	COG1597	lipid kinase activity
A8713_RS29830	COG1140	nitrate reductase beta subunit
A8713_RS29850	COG3469	chitinase activity
A8713_RS29855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8713_RS29875	COG0583	DNA-binding transcription factor activity
A8713_RS29895	COG1063	alcohol dehydrogenase
A8713_RS29940	COG2837	iron assimilation
A8713_RS29960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8713_RS29990	COG1231	oxidoreductase activity
A8713_RS30010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8713_RS30025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8713_RS30030	COG4948	Mandelate Racemase Muconate Lactonizing
A8713_RS30060	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A8713_RS30080	COG0531	amino acid
A8713_RS30095	COG0583	DNA-binding transcription factor activity
A8713_RS30100	COG5640	endopeptidase activity
A8713_RS30125	COG3537	Alpha-1,2-mannosidase
A8713_RS30130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8713_RS30135	COG0395	ABC-type sugar transport system, permease component
A8713_RS30165	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A8713_RS30195	COG2814	Major facilitator Superfamily
A8713_RS30220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8713_RS30225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8713_RS30235	COG0438	transferase activity, transferring glycosyl groups
A8713_RS30260	COG3511	phospholipase C
A8713_RS30270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8713_RS30285	COG1309	transcriptional regulator
A8713_RS30290	COG0438	transferase activity, transferring glycosyl groups
A8713_RS30290	COG1216	Glycosyl transferase, family 2
A8713_RS30305	COG1131	(ABC) transporter
A8713_RS30340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8713_RS30360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8713_RS30365	COG1132	(ABC) transporter
A8713_RS30370	COG1132	(ABC) transporter
A8713_RS30375	COG0156	8-amino-7-oxononanoate synthase activity
A8713_RS30380	COG0318	PFAM AMP-dependent synthetase and ligase
A8713_RS30395	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS30425	COG0583	DNA-binding transcription factor activity
A8713_RS30445	COG1733	regulation of RNA biosynthetic process
A8713_RS30455	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS30460	COG1228	amidohydrolase
A8713_RS30480	COG1683	Conserved Protein
A8713_RS30485	COG2815	serine threonine protein kinase
A8713_RS30485	COG0515	serine threonine protein kinase
A8713_RS30505	COG4977	sequence-specific DNA binding
A8713_RS30555	COG0583	DNA-binding transcription factor activity
A8713_RS30565	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS30570	COG3537	Alpha-1,2-mannosidase
A8713_RS30585	COG1486	melibiose metabolic process
A8713_RS30590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8713_RS30595	COG0395	ABC-type sugar transport system, permease component
A8713_RS30600	COG1175	transmembrane transport
A8713_RS30615	COG1349	DNA-binding transcription factor activity
A8713_RS30630	COG2755	lipolytic protein G-D-S-L family
A8713_RS30640	COG0667	Aldo Keto reductase
A8713_RS30675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8713_RS30690	COG2188	Transcriptional regulator
A8713_RS30700	COG0300	oxidoreductase activity
A8713_RS30710	COG0477	Major facilitator Superfamily
A8713_RS30730	COG0745	RESPONSE REGULATOR receiver
A8713_RS30745	COG0308	aminopeptidase N
A8713_RS30775	COG0701	Predicted permease
A8713_RS30800	COG0784	Response regulator, receiver
A8713_RS30805	COG4251	negative regulation of phosphorylation
A8713_RS30855	COG1470	cell adhesion involved in biofilm formation
A8713_RS30855	COG0366	Alpha amylase catalytic
A8713_RS30865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8713_RS30865	COG0519	Catalyzes the synthesis of GMP from XMP
A8713_RS30885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8713_RS30885	COG2080	2 iron, 2 sulfur cluster binding
A8713_RS30905	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A8713_RS30935	COG2239	Acts as a magnesium transporter
A8713_RS30945	COG0823	Involved in the tonB-independent uptake of proteins
A8713_RS30945	COG4946	Tricorn protease homolog
A8713_RS30945	COG1506	peptidase
A8713_RS31000	COG2362	D-Aminopeptidase
A8713_RS31010	COG2226	methyltransferase
A8713_RS31030	COG1228	amidohydrolase
A8713_RS31040	COG1960	acyl-CoA dehydrogenase activity
A8713_RS31070	COG3959	Transketolase, thiamine diphosphate binding domain
A8713_RS31075	COG3958	Transketolase
A8713_RS31085	COG0189	ligase activity
A8713_RS31090	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8713_RS31100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8713_RS31120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8713_RS31135	COG0529	Catalyzes the synthesis of activated sulfate
A8713_RS31150	COG1660	Displays ATPase and GTPase activities
A8713_RS31160	COG0753	catalase activity
A8713_RS31185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8713_RS31195	COG0009	L-threonylcarbamoyladenylate synthase
A8713_RS31205	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A8713_RS31210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS31215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8713_RS31220	COG1120	ATPase activity
A8713_RS31225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A8713_RS31230	COG1132	(ABC) transporter
A8713_RS31240	COG1132	(ABC) transporter
A8713_RS31245	COG2382	esterase
A8713_RS31260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8713_RS31265	COG3340	Belongs to the peptidase S51 family
A8713_RS31280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A8713_RS31285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8713_RS31305	COG0681	Belongs to the peptidase S26 family
A8713_RS31315	COG1132	(ABC) transporter
A8713_RS31345	COG3227	Zinc metalloprotease (Elastase)
A8713_RS31355	COG0702	epimerase
A8713_RS31360	COG1733	regulation of RNA biosynthetic process
A8713_RS31365	COG0488	(ABC) transporter
A8713_RS31370	COG2072	flavoprotein involved in K transport
A8713_RS31375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8713_RS31380	COG0475	glutathione-regulated potassium exporter activity
A8713_RS31400	COG2986	histidine ammonia-lyase
A8713_RS31405	COG2205	protein histidine kinase activity
A8713_RS31410	COG0745	RESPONSE REGULATOR receiver
A8713_RS31420	COG0577	efflux transmembrane transporter activity
A8713_RS31420	COG1136	(ABC) transporter
A8713_RS31430	COG2197	response regulator
A8713_RS31435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8713_RS31440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8713_RS31455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8713_RS31455	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A8713_RS31470	COG1028	Short-chain dehydrogenase reductase Sdr
A8713_RS31480	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A8713_RS31530	COG5002	protein histidine kinase activity
A8713_RS31530	COG0784	Response regulator, receiver
A8713_RS31530	COG2205	protein histidine kinase activity
A8713_RS31550	COG1309	transcriptional regulator
A8713_RS31600	COG0515	serine threonine protein kinase
A8713_RS31600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8713_RS31610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8713_RS31655	COG1191	sigma factor activity
A8713_RS31665	COG0069	glutamate synthase activity
A8713_RS31670	COG1366	Belongs to the anti-sigma-factor antagonist family
A8713_RS31675	COG1366	Belongs to the anti-sigma-factor antagonist family
A8713_RS31680	COG2172	sigma factor antagonist activity
A8713_RS31690	COG2198	Histidine kinase
A8713_RS31690	COG0784	Response regulator, receiver
A8713_RS31690	COG5002	protein histidine kinase activity
A8713_RS31715	COG2027	D-alanyl-D-alanine carboxypeptidase