locus-tag	class	description
CAG99_RS00030	COG2030	dehydratase
CAG99_RS00035	COG0156	8-amino-7-oxononanoate synthase activity
CAG99_RS00040	COG2301	Belongs to the HpcH HpaI aldolase family
CAG99_RS00045	COG2319	Wd-40 repeat
CAG99_RS00045	COG4249	Peptidase C14 caspase catalytic subunit p20
CAG99_RS00055	COG2072	flavoprotein involved in K transport
CAG99_RS00070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAG99_RS00095	COG0431	NADPH-dependent FMN reductase
CAG99_RS00100	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CAG99_RS00110	COG4124	Belongs to the glycosyl hydrolase 26 family
CAG99_RS00115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAG99_RS00120	COG3397	chitin binding
CAG99_RS00135	COG1132	(ABC) transporter
CAG99_RS00155	COG2018	Roadblock/LC7 domain
CAG99_RS00170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CAG99_RS00180	COG2755	lipolytic protein G-D-S-L family
CAG99_RS00230	COG0596	Alpha beta hydrolase
CAG99_RS00235	COG1609	Transcriptional regulator
CAG99_RS00250	COG1940	carbohydrate kinase activity
CAG99_RS00265	COG0318	PFAM AMP-dependent synthetase and ligase
CAG99_RS00270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CAG99_RS00270	COG0825	malonyl-CoA metabolic process
CAG99_RS00285	COG0697	spore germination
CAG99_RS00295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAG99_RS00300	COG2197	response regulator
CAG99_RS00305	COG4608	Belongs to the ABC transporter superfamily
CAG99_RS00310	COG0444	Belongs to the ABC transporter superfamily
CAG99_RS00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAG99_RS00320	COG0601	transmembrane transport
CAG99_RS00330	COG3458	cephalosporin-C deacetylase activity
CAG99_RS00375	COG1674	ftsk spoiiie
CAG99_RS00440	COG0494	nUDIX hydrolase
CAG99_RS00540	COG3321	synthase
CAG99_RS00540	COG0604	alcohol dehydrogenase
CAG99_RS00545	COG0604	alcohol dehydrogenase
CAG99_RS00545	COG3321	synthase
CAG99_RS00550	COG3321	synthase
CAG99_RS00550	COG0604	alcohol dehydrogenase
CAG99_RS00555	COG0604	alcohol dehydrogenase
CAG99_RS00555	COG3321	synthase
CAG99_RS00570	COG0604	alcohol dehydrogenase
CAG99_RS00570	COG3321	synthase
CAG99_RS00595	COG3321	synthase
CAG99_RS00595	COG0604	alcohol dehydrogenase
CAG99_RS00605	COG0604	alcohol dehydrogenase
CAG99_RS00605	COG3321	synthase
CAG99_RS00610	COG3321	synthase
CAG99_RS00610	COG0604	alcohol dehydrogenase
CAG99_RS00650	COG1846	Transcriptional regulator
CAG99_RS00655	COG1131	(ABC) transporter
CAG99_RS00660	COG3559	Exporter of polyketide antibiotics
CAG99_RS00675	COG1309	transcriptional regulator
CAG99_RS00680	COG1802	Transcriptional regulator
CAG99_RS00685	COG1063	alcohol dehydrogenase
CAG99_RS00690	COG1846	Transcriptional regulator
CAG99_RS00695	COG2409	Drug exporters of the RND superfamily
CAG99_RS00705	COG1012	belongs to the aldehyde dehydrogenase family
CAG99_RS00715	COG0326	Molecular chaperone. Has ATPase activity
CAG99_RS00725	COG0693	protein deglycase activity
CAG99_RS00785	COG3046	protein related to deoxyribodipyrimidine photolyase
CAG99_RS00795	COG1302	Protein conserved in bacteria
CAG99_RS00805	COG2207	Transcriptional regulator
CAG99_RS00810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS00815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS00820	COG1120	ATPase activity
CAG99_RS00840	COG0662	Cupin 2, conserved barrel domain protein
CAG99_RS00845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAG99_RS00850	COG1132	(ABC) transporter
CAG99_RS00855	COG2375	cellular response to nickel ion
CAG99_RS00855	COG1132	(ABC) transporter
CAG99_RS00860	COG0789	Transcriptional regulator
CAG99_RS00865	COG3708	Transcriptional regulator
CAG99_RS00865	COG2207	Transcriptional regulator
CAG99_RS00880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAG99_RS00910	COG1280	lysine exporter protein (LysE YggA)
CAG99_RS00920	COG2226	methyltransferase
CAG99_RS00935	COG1032	radical SAM domain protein
CAG99_RS00955	COG0456	acetyltransferase
CAG99_RS00955	COG1846	Transcriptional regulator
CAG99_RS01010	COG1120	ATPase activity
CAG99_RS01015	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS01020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS01070	COG0673	inositol 2-dehydrogenase activity
CAG99_RS01105	COG2318	DinB family
CAG99_RS01115	COG0477	Major facilitator Superfamily
CAG99_RS01135	COG0477	Major facilitator Superfamily
CAG99_RS01145	COG0673	inositol 2-dehydrogenase activity
CAG99_RS01150	COG1129	ABC transporter
CAG99_RS01155	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAG99_RS01165	COG1879	ABC-type sugar transport system periplasmic component
CAG99_RS01190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CAG99_RS01195	COG4124	Belongs to the glycosyl hydrolase 26 family
CAG99_RS01245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CAG99_RS01250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAG99_RS01255	COG3285	dna ligase
CAG99_RS01255	COG1793	dna ligase
CAG99_RS01260	COG0693	protein deglycase activity
CAG99_RS01270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CAG99_RS01310	COG4608	Belongs to the ABC transporter superfamily
CAG99_RS01315	COG0444	Belongs to the ABC transporter superfamily
CAG99_RS01320	COG0601	transmembrane transport
CAG99_RS01345	COG0494	nUDIX hydrolase
CAG99_RS01355	COG0492	ferredoxin-NADP+ reductase activity
CAG99_RS01365	COG0537	adenosine 5'-monophosphoramidase activity
CAG99_RS01370	COG1793	dna ligase
CAG99_RS01385	COG0156	8-amino-7-oxononanoate synthase activity
CAG99_RS01390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CAG99_RS01395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CAG99_RS01400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CAG99_RS01415	COG1175	transmembrane transport
CAG99_RS01420	COG0395	ABC-type sugar transport system, permease component
CAG99_RS01430	COG1501	Belongs to the glycosyl hydrolase 31 family
CAG99_RS01450	COG0596	Alpha beta hydrolase
CAG99_RS01455	COG3629	intracellular signal transduction
CAG99_RS01455	COG3903	Transcriptional regulator
CAG99_RS01480	COG3265	gluconokinase activity
CAG99_RS01490	COG0673	inositol 2-dehydrogenase activity
CAG99_RS01495	COG1879	ABC-type sugar transport system periplasmic component
CAG99_RS01500	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAG99_RS01505	COG1129	ABC transporter
CAG99_RS01510	COG1940	carbohydrate kinase activity
CAG99_RS01520	COG1652	LysM domain
CAG99_RS01535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CAG99_RS01540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAG99_RS01550	COG3145	DNA-N1-methyladenine dioxygenase activity
CAG99_RS01560	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CAG99_RS01570	COG1562	ergosterol biosynthetic process
CAG99_RS01575	COG1134	teichoic acid transport
CAG99_RS01595	COG0371	Dehydrogenase
CAG99_RS01620	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CAG99_RS01635	COG1132	(ABC) transporter
CAG99_RS01640	COG0488	(ABC) transporter
CAG99_RS01650	COG2183	response to ionizing radiation
CAG99_RS01660	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAG99_RS01660	COG1024	Enoyl-CoA hydratase
CAG99_RS01665	COG0183	Belongs to the thiolase family
CAG99_RS01675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAG99_RS01680	COG1940	carbohydrate kinase activity
CAG99_RS01745	COG1515	deoxyribonuclease V activity
CAG99_RS01750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAG99_RS01760	COG3360	Dodecin
CAG99_RS01865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAG99_RS01915	COG4221	oxidoreductase activity
CAG99_RS01920	COG0745	RESPONSE REGULATOR receiver
CAG99_RS01925	COG2205	protein histidine kinase activity
CAG99_RS01965	COG0789	Transcriptional regulator
CAG99_RS01970	COG0477	Major facilitator Superfamily
CAG99_RS01995	COG1278	Cold shock
CAG99_RS02005	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CAG99_RS02030	COG1793	dna ligase
CAG99_RS02030	COG3285	dna ligase
CAG99_RS02055	COG1501	Belongs to the glycosyl hydrolase 31 family
CAG99_RS02065	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS02085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAG99_RS02120	COG0517	IMP dehydrogenase activity
CAG99_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS02135	COG0028	Belongs to the TPP enzyme family
CAG99_RS02140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAG99_RS02150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAG99_RS02155	COG2192	nodulation
CAG99_RS02165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CAG99_RS02170	COG0859	PFAM glycosyl transferase family 9
CAG99_RS02180	COG0438	transferase activity, transferring glycosyl groups
CAG99_RS02185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CAG99_RS02190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CAG99_RS02190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CAG99_RS02195	COG0859	PFAM glycosyl transferase family 9
CAG99_RS02230	COG0517	IMP dehydrogenase activity
CAG99_RS02280	COG0471	metal ion transport
CAG99_RS02285	COG1349	DNA-binding transcription factor activity
CAG99_RS02295	COG1175	transmembrane transport
CAG99_RS02300	COG0395	ABC-type sugar transport system, permease component
CAG99_RS02320	COG0604	alcohol dehydrogenase
CAG99_RS02320	COG3321	synthase
CAG99_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS02340	COG1012	belongs to the aldehyde dehydrogenase family
CAG99_RS02345	COG0583	DNA-binding transcription factor activity
CAG99_RS02375	COG0431	NADPH-dependent FMN reductase
CAG99_RS02380	COG1132	(ABC) transporter
CAG99_RS02385	COG0277	FAD linked oxidase domain protein
CAG99_RS02410	COG1309	transcriptional regulator
CAG99_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS02445	COG1960	acyl-CoA dehydrogenase activity
CAG99_RS02455	COG1309	transcriptional regulator
CAG99_RS02465	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS02485	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAG99_RS02495	COG0656	L-ascorbic acid biosynthetic process
CAG99_RS02500	COG2154	pterin-4-alpha-carbinolamine dehydratase
CAG99_RS02530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CAG99_RS02540	COG1733	regulation of RNA biosynthetic process
CAG99_RS02565	COG0667	Aldo Keto reductase
CAG99_RS02570	COG0583	DNA-binding transcription factor activity
CAG99_RS02585	COG1063	alcohol dehydrogenase
CAG99_RS02590	COG0395	ABC-type sugar transport system, permease component
CAG99_RS02610	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CAG99_RS02630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAG99_RS02635	COG2362	D-Aminopeptidase
CAG99_RS02645	COG1366	Belongs to the anti-sigma-factor antagonist family
CAG99_RS02645	COG2172	sigma factor antagonist activity
CAG99_RS02645	COG2208	phosphoserine phosphatase activity
CAG99_RS02655	COG2249	NAD(P)H dehydrogenase (quinone) activity
CAG99_RS02680	COG1801	Protein of unknown function DUF72
CAG99_RS02690	COG0463	Glycosyl transferase, family 2
CAG99_RS02700	COG1309	transcriptional regulator
CAG99_RS02705	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS02720	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CAG99_RS02735	COG2301	Belongs to the HpcH HpaI aldolase family
CAG99_RS02740	COG0688	phosphatidylethanolamine metabolic process
CAG99_RS02770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAG99_RS02795	COG0723	plastoquinol--plastocyanin reductase activity
CAG99_RS02795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAG99_RS02825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAG99_RS02830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAG99_RS02875	COG0366	Alpha amylase catalytic
CAG99_RS02880	COG2124	cytochrome p450
CAG99_RS02885	COG0531	amino acid
CAG99_RS02905	COG2223	nitrite transmembrane transporter activity
CAG99_RS02915	COG0395	ABC-type sugar transport system, permease component
CAG99_RS02920	COG1175	transmembrane transport
CAG99_RS02930	COG1609	Transcriptional regulator
CAG99_RS02940	COG0500	methyltransferase
CAG99_RS02950	COG1132	(ABC) transporter
CAG99_RS02955	COG1404	Belongs to the peptidase S8 family
CAG99_RS02965	COG0515	serine threonine protein kinase
CAG99_RS02990	COG1609	Transcriptional regulator
CAG99_RS03000	COG1191	sigma factor activity
CAG99_RS03020	COG4948	Mandelate Racemase Muconate Lactonizing
CAG99_RS03040	COG0702	epimerase
CAG99_RS03060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAG99_RS03075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CAG99_RS03080	COG0405	Gamma-glutamyltransferase
CAG99_RS03100	COG1733	regulation of RNA biosynthetic process
CAG99_RS03110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAG99_RS03120	COG0483	inositol monophosphate 1-phosphatase activity
CAG99_RS03130	COG1929	Belongs to the glycerate kinase type-1 family
CAG99_RS03145	COG1940	carbohydrate kinase activity
CAG99_RS03160	COG4266	Belongs to the allantoicase family
CAG99_RS03165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAG99_RS03170	COG1414	Transcriptional regulator
CAG99_RS03180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CAG99_RS03190	COG1162	GTPase activity
CAG99_RS03195	COG2226	methyltransferase
CAG99_RS03235	COG2351	hydroxyisourate hydrolase activity
CAG99_RS03265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAG99_RS03295	COG1802	Transcriptional regulator
CAG99_RS03320	COG3467	pyridoxamine 5'-phosphate
CAG99_RS03355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CAG99_RS03360	COG5297	Belongs to the glycosyl hydrolase family 6
CAG99_RS03370	COG1960	acyl-CoA dehydrogenase activity
CAG99_RS03390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAG99_RS03390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAG99_RS03395	COG0583	DNA-binding transcription factor activity
CAG99_RS03405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAG99_RS03415	COG0175	sulfate reduction
CAG99_RS03420	COG0529	Catalyzes the synthesis of activated sulfate
CAG99_RS03435	COG4521	taurine ABC transporter
CAG99_RS03440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAG99_RS03445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAG99_RS03455	COG0745	RESPONSE REGULATOR receiver
CAG99_RS03490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CAG99_RS03530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAG99_RS03535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAG99_RS03555	COG2326	polyphosphate kinase activity
CAG99_RS03560	COG3253	May function as heme-dependent peroxidase
CAG99_RS03565	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CAG99_RS03570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CAG99_RS03580	COG2197	response regulator
CAG99_RS03585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CAG99_RS03590	COG0183	Belongs to the thiolase family
CAG99_RS03595	COG1024	Enoyl-CoA hydratase
CAG99_RS03595	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAG99_RS03610	COG1064	alcohol dehydrogenase
CAG99_RS03620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CAG99_RS03625	COG4214	carbohydrate transport
CAG99_RS03635	COG4213	ABC transporter substrate-binding protein
CAG99_RS03640	COG1940	carbohydrate kinase activity
CAG99_RS03645	COG0395	ABC-type sugar transport system, permease component
CAG99_RS03650	COG1175	transmembrane transport
CAG99_RS03655	COG1653	transport
CAG99_RS03660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CAG99_RS03665	COG1335	isochorismatase
CAG99_RS03690	COG1733	regulation of RNA biosynthetic process
CAG99_RS03695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAG99_RS03730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAG99_RS03750	COG0456	acetyltransferase
CAG99_RS03765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAG99_RS03770	COG2040	homocysteine
CAG99_RS03780	COG3629	intracellular signal transduction
CAG99_RS03780	COG3903	Transcriptional regulator
CAG99_RS03785	COG3654	unkown
CAG99_RS03830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAG99_RS03835	COG0569	domain protein
CAG99_RS03875	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CAG99_RS03880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CAG99_RS03885	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CAG99_RS03905	COG0756	dUTP diphosphatase activity
CAG99_RS03920	COG2205	protein histidine kinase activity
CAG99_RS03925	COG0745	RESPONSE REGULATOR receiver
CAG99_RS03930	COG0483	inositol monophosphate 1-phosphatase activity
CAG99_RS03935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CAG99_RS03955	COG1435	thymidine kinase activity
CAG99_RS03975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAG99_RS03980	COG1802	Transcriptional regulator
CAG99_RS03990	COG0612	Peptidase, M16
CAG99_RS03995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CAG99_RS04005	COG0187	DNA topoisomerase II activity
CAG99_RS04015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAG99_RS04020	COG1802	Transcriptional regulator
CAG99_RS04025	COG1131	(ABC) transporter
CAG99_RS04045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAG99_RS04050	COG0588	phosphoglycerate mutase activity
CAG99_RS04060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAG99_RS04065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAG99_RS04070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CAG99_RS04100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CAG99_RS04110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAG99_RS04115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAG99_RS04120	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CAG99_RS04130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CAG99_RS04150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAG99_RS04165	COG0642	Histidine kinase
CAG99_RS04170	COG0745	RESPONSE REGULATOR receiver
CAG99_RS04175	COG1126	abc transporter atp-binding protein
CAG99_RS04180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAG99_RS04185	COG0765	amino acid transport
CAG99_RS04190	COG0765	amino acid transport
CAG99_RS04195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAG99_RS04200	COG2137	regulation of response to DNA damage stimulus
CAG99_RS04205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CAG99_RS04215	COG1201	RNA secondary structure unwinding
CAG99_RS04220	COG1396	sequence-specific DNA binding
CAG99_RS04225	COG1546	Belongs to the CinA family
CAG99_RS04225	COG1058	Belongs to the CinA family
CAG99_RS04235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAG99_RS04245	COG1674	ftsk spoiiie
CAG99_RS04255	COG4999	Histidine kinase
CAG99_RS04255	COG3437	response regulator, receiver
CAG99_RS04255	COG2205	protein histidine kinase activity
CAG99_RS04255	COG3850	Histidine kinase
CAG99_RS04260	COG2770	Histidine kinase
CAG99_RS04260	COG2208	phosphoserine phosphatase activity
CAG99_RS04285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CAG99_RS04290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAG99_RS04295	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CAG99_RS04315	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CAG99_RS04320	COG0612	Peptidase, M16
CAG99_RS04325	COG1185	polyribonucleotide nucleotidyltransferase activity
CAG99_RS04330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAG99_RS04340	COG1674	ftsk spoiiie
CAG99_RS04345	COG1404	Belongs to the peptidase S8 family
CAG99_RS04365	COG1404	Belongs to the peptidase S8 family
CAG99_RS04395	COG0455	bacterial-type flagellum organization
CAG99_RS04405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CAG99_RS04410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CAG99_RS04420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CAG99_RS04435	COG0779	Required for maturation of 30S ribosomal subunits
CAG99_RS04455	COG0442	prolyl-tRNA aminoacylation
CAG99_RS04460	COG0456	acetyltransferase
CAG99_RS04465	COG0454	-acetyltransferase
CAG99_RS04465	COG0456	acetyltransferase
CAG99_RS04470	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CAG99_RS04475	COG0750	zinc metalloprotease
CAG99_RS04480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CAG99_RS04550	COG0395	ABC-type sugar transport system, permease component
CAG99_RS04555	COG4209	transmembrane transport
CAG99_RS04565	COG1472	Belongs to the glycosyl hydrolase 3 family
CAG99_RS04585	COG2508	Transcriptional regulator
CAG99_RS04595	COG3842	ATPase activity
CAG99_RS04605	COG0259	pyridoxamine-phosphate oxidase activity
CAG99_RS04630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAG99_RS04640	COG1012	belongs to the aldehyde dehydrogenase family
CAG99_RS04645	COG1136	(ABC) transporter
CAG99_RS04660	COG3842	ATPase activity
CAG99_RS04665	COG1177	transmembrane transport
CAG99_RS04675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CAG99_RS04680	COG0575	Belongs to the CDS family
CAG99_RS04685	COG0233	cytoplasmic translational termination
CAG99_RS04690	COG0528	UMP kinase activity
CAG99_RS04695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CAG99_RS04700	COG0052	Belongs to the universal ribosomal protein uS2 family
CAG99_RS04705	COG0792	nuclease activity
CAG99_RS04720	COG1191	sigma factor activity
CAG99_RS04745	COG0681	Belongs to the peptidase S26 family
CAG99_RS04750	COG0681	Belongs to the peptidase S26 family
CAG99_RS04760	COG0335	large ribosomal subunit rRNA binding
CAG99_RS04765	COG0336	Belongs to the RNA methyltransferase TrmD family
CAG99_RS04770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CAG99_RS04775	COG1837	Belongs to the UPF0109 family
CAG99_RS04780	COG0228	four-way junction DNA binding
CAG99_RS04800	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CAG99_RS04830	COG0477	Major facilitator Superfamily
CAG99_RS04835	COG1196	nuclear chromosome segregation
CAG99_RS04845	COG1254	Belongs to the acylphosphatase family
CAG99_RS04850	COG2340	Cysteine-rich secretory protein family
CAG99_RS04855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAG99_RS04860	COG0571	ribonuclease III activity
CAG99_RS04865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CAG99_RS04880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CAG99_RS04885	COG0742	ribosomal rna small subunit methyltransferase
CAG99_RS04905	COG1461	Dihydroxyacetone kinase
CAG99_RS04910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CAG99_RS04915	COG0351	phosphomethylpyrimidine kinase
CAG99_RS04935	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAG99_RS04940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAG99_RS04950	COG1920	GTP binding
CAG99_RS04960	COG0776	regulation of translation
CAG99_RS04970	COG0066	3-isopropylmalate dehydratase activity
CAG99_RS04975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAG99_RS04980	COG1414	Transcriptional regulator
CAG99_RS05010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAG99_RS05015	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAG99_RS05030	COG2018	Roadblock/LC7 domain
CAG99_RS05050	COG2018	Roadblock/LC7 domain
CAG99_RS05065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAG99_RS05070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAG99_RS05075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAG99_RS05080	COG0473	3-isopropylmalate dehydrogenase activity
CAG99_RS05090	COG1012	belongs to the aldehyde dehydrogenase family
CAG99_RS05095	COG0506	proline dehydrogenase activity
CAG99_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS05125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAG99_RS05130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CAG99_RS05135	COG0440	acetolactate synthase activity
CAG99_RS05155	COG0667	Aldo Keto reductase
CAG99_RS05160	COG2133	pyrroloquinoline quinone binding
CAG99_RS05165	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CAG99_RS05165	COG1672	PFAM Archaeal ATPase
CAG99_RS05175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAG99_RS05185	COG0154	amidase activity
CAG99_RS05190	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAG99_RS05200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CAG99_RS05220	COG0482	sulfurtransferase activity
CAG99_RS05225	COG0456	acetyltransferase
CAG99_RS05255	COG2205	protein histidine kinase activity
CAG99_RS05260	COG0745	RESPONSE REGULATOR receiver
CAG99_RS05270	COG1929	Belongs to the glycerate kinase type-1 family
CAG99_RS05290	COG0783	Belongs to the Dps family
CAG99_RS05305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAG99_RS05310	COG0509	glycine decarboxylation via glycine cleavage system
CAG99_RS05315	COG1760	l-serine dehydratase
CAG99_RS05320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS05325	COG1120	ATPase activity
CAG99_RS05335	COG1132	(ABC) transporter
CAG99_RS05340	COG1132	(ABC) transporter
CAG99_RS05345	COG0318	PFAM AMP-dependent synthetase and ligase
CAG99_RS05385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAG99_RS05395	COG1376	ErfK ybiS ycfS ynhG family protein
CAG99_RS05425	COG1132	(ABC) transporter
CAG99_RS05430	COG1132	(ABC) transporter
CAG99_RS05435	COG0058	SHG alpha-glucan phosphorylase activity
CAG99_RS05440	COG4608	Belongs to the ABC transporter superfamily
CAG99_RS05450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAG99_RS05455	COG0601	transmembrane transport
CAG99_RS05460	COG0747	negative chemotaxis
CAG99_RS05465	COG0366	Alpha amylase catalytic
CAG99_RS05470	COG0366	Alpha amylase catalytic
CAG99_RS05475	COG3281	Trehalose synthase
CAG99_RS05485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CAG99_RS05485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CAG99_RS05505	COG0739	heme binding
CAG99_RS05565	COG0205	6-phosphofructokinase activity
CAG99_RS05570	COG0857	belongs to the CobB CobQ family
CAG99_RS05570	COG0280	phosphate acetyltransferase
CAG99_RS05575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CAG99_RS05605	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CAG99_RS05605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CAG99_RS05645	COG2205	protein histidine kinase activity
CAG99_RS05650	COG0745	RESPONSE REGULATOR receiver
CAG99_RS05665	COG0183	Belongs to the thiolase family
CAG99_RS05740	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CAG99_RS05760	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAG99_RS05775	COG4585	Histidine kinase
CAG99_RS05780	COG2197	response regulator
CAG99_RS05795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAG99_RS05800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAG99_RS05805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAG99_RS05810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CAG99_RS05815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAG99_RS05820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CAG99_RS05825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAG99_RS05845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAG99_RS05855	COG2890	protein-(glutamine-N5) methyltransferase activity
CAG99_RS05860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAG99_RS05865	COG0254	rRNA binding
CAG99_RS05870	COG1316	TRANSCRIPTIONal
CAG99_RS05880	COG0083	homoserine kinase activity
CAG99_RS05885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CAG99_RS05890	COG0460	homoserine dehydrogenase
CAG99_RS05895	COG0019	diaminopimelate decarboxylase activity
CAG99_RS05900	COG0018	arginyl-trna synthetase
CAG99_RS05900	COG0018	arginyl-trna synthetase
CAG99_RS05905	COG0745	RESPONSE REGULATOR receiver
CAG99_RS05920	COG4221	oxidoreductase activity
CAG99_RS05925	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS05935	COG0431	NADPH-dependent FMN reductase
CAG99_RS05940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAG99_RS05960	COG0367	asparagine synthase
CAG99_RS05965	COG2814	Major facilitator Superfamily
CAG99_RS05970	COG1309	transcriptional regulator
CAG99_RS05990	COG0736	holo-[acyl-carrier-protein] synthase activity
CAG99_RS06030	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CAG99_RS06040	COG0736	holo-[acyl-carrier-protein] synthase activity
CAG99_RS06060	COG0367	asparagine synthase
CAG99_RS06105	COG4249	Peptidase C14 caspase catalytic subunit p20
CAG99_RS06105	COG2319	Wd-40 repeat
CAG99_RS06145	COG0583	DNA-binding transcription factor activity
CAG99_RS06150	COG2409	Drug exporters of the RND superfamily
CAG99_RS06155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAG99_RS06160	COG0798	PFAM Bile acid sodium symporter
CAG99_RS06185	COG1404	Belongs to the peptidase S8 family
CAG99_RS06215	COG0702	epimerase
CAG99_RS06240	COG1595	DNA-templated transcription, initiation
CAG99_RS06320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAG99_RS06380	COG1674	ftsk spoiiie
CAG99_RS06415	COG0142	geranyltranstransferase activity
CAG99_RS06425	COG0596	Alpha beta hydrolase
CAG99_RS06430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CAG99_RS06450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAG99_RS06465	COG0586	Pfam SNARE associated Golgi protein
CAG99_RS06470	COG4585	Histidine kinase
CAG99_RS06475	COG2197	response regulator
CAG99_RS06535	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CAG99_RS06540	COG0438	transferase activity, transferring glycosyl groups
CAG99_RS06555	COG1796	DNA polymerase
CAG99_RS06555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CAG99_RS06570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAG99_RS06585	COG1309	transcriptional regulator
CAG99_RS06605	COG0024	Methionine aminopeptidase
CAG99_RS06630	COG0745	RESPONSE REGULATOR receiver
CAG99_RS06635	COG2205	protein histidine kinase activity
CAG99_RS06640	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAG99_RS06640	COG0567	Dehydrogenase, E1 component
CAG99_RS06645	COG2842	Transposition protein
CAG99_RS06670	COG2255	four-way junction helicase activity
CAG99_RS06705	COG1695	Transcriptional regulator
CAG99_RS06720	COG0604	alcohol dehydrogenase
CAG99_RS06730	COG1126	abc transporter atp-binding protein
CAG99_RS06735	COG0765	amino acid transport
CAG99_RS06745	COG0281	malic enzyme
CAG99_RS06750	COG4106	trans-aconitate 2-methyltransferase activity
CAG99_RS06770	COG0475	glutathione-regulated potassium exporter activity
CAG99_RS06775	COG0475	glutathione-regulated potassium exporter activity
CAG99_RS06780	COG3973	AAA domain
CAG99_RS06805	COG1597	lipid kinase activity
CAG99_RS06820	COG1309	transcriptional regulator
CAG99_RS06825	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS06830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAG99_RS06835	COG1472	Belongs to the glycosyl hydrolase 3 family
CAG99_RS06840	COG0395	ABC-type sugar transport system, permease component
CAG99_RS06845	COG1175	transmembrane transport
CAG99_RS06850	COG2182	Extracellular solute-binding protein
CAG99_RS06855	COG2188	Transcriptional regulator
CAG99_RS06860	COG0659	secondary active sulfate transmembrane transporter activity
CAG99_RS06865	COG0288	reversible hydration of carbon dioxide
CAG99_RS06870	COG1966	Carbon starvation protein
CAG99_RS06895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAG99_RS06905	COG0242	peptide deformylase activity
CAG99_RS06915	COG5662	AntiSigma factor
CAG99_RS06920	COG1595	DNA-templated transcription, initiation
CAG99_RS06925	COG2135	peptidase activity
CAG99_RS06930	COG5297	Belongs to the glycosyl hydrolase family 6
CAG99_RS06935	COG4733	cellulase activity
CAG99_RS06935	COG5297	Belongs to the glycosyl hydrolase family 6
CAG99_RS06950	COG4733	cellulase activity
CAG99_RS06950	COG5297	Belongs to the glycosyl hydrolase family 6
CAG99_RS06955	COG5297	Belongs to the glycosyl hydrolase family 6
CAG99_RS07025	COG1609	Transcriptional regulator
CAG99_RS07050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAG99_RS07070	COG1595	DNA-templated transcription, initiation
CAG99_RS07090	COG0406	alpha-ribazole phosphatase activity
CAG99_RS07125	COG5001	Diguanylate cyclase
CAG99_RS07125	COG3300	MHYT domain
CAG99_RS07150	COG0154	amidase activity
CAG99_RS07165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CAG99_RS07180	COG0673	inositol 2-dehydrogenase activity
CAG99_RS07185	COG1609	Transcriptional regulator
CAG99_RS07200	COG0110	maltose O-acetyltransferase activity
CAG99_RS07210	COG0494	nUDIX hydrolase
CAG99_RS07230	COG0655	NAD(P)H dehydrogenase (quinone) activity
CAG99_RS07250	COG1946	Acyl-CoA thioesterase
CAG99_RS07265	COG0753	catalase activity
CAG99_RS07270	COG0504	CTP synthase activity
CAG99_RS07285	COG0167	dihydroorotate dehydrogenase activity
CAG99_RS07295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAG99_RS07300	COG0778	Nitroreductase
CAG99_RS07305	COG1733	regulation of RNA biosynthetic process
CAG99_RS07310	COG0477	Major facilitator Superfamily
CAG99_RS07315	COG0483	inositol monophosphate 1-phosphatase activity
CAG99_RS07325	COG1162	GTPase activity
CAG99_RS07330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CAG99_RS07365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CAG99_RS07380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAG99_RS07395	COG1960	acyl-CoA dehydrogenase activity
CAG99_RS07410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAG99_RS07425	COG1615	UPF0182 protein
CAG99_RS07435	COG3480	Lon protease (S16) C-terminal proteolytic domain
CAG99_RS07485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAG99_RS07550	COG0596	Alpha beta hydrolase
CAG99_RS07555	COG4122	O-methyltransferase activity
CAG99_RS07620	COG0613	PHP domain protein
CAG99_RS07630	COG0513	Belongs to the DEAD box helicase family
CAG99_RS07660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAG99_RS07665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAG99_RS07675	COG1595	DNA-templated transcription, initiation
CAG99_RS07690	COG1024	Enoyl-CoA hydratase
CAG99_RS07700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CAG99_RS07705	COG1611	Belongs to the LOG family
CAG99_RS07710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAG99_RS07750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CAG99_RS07760	COG4608	Belongs to the ABC transporter superfamily
CAG99_RS07765	COG0444	Belongs to the ABC transporter superfamily
CAG99_RS07770	COG0601	transmembrane transport
CAG99_RS07775	COG0747	negative chemotaxis
CAG99_RS07780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAG99_RS07785	COG4608	Belongs to the ABC transporter superfamily
CAG99_RS07795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAG99_RS07800	COG0601	transmembrane transport
CAG99_RS07805	COG4166	transmembrane transport
CAG99_RS07820	COG4608	Belongs to the ABC transporter superfamily
CAG99_RS07840	COG4166	transmembrane transport
CAG99_RS07845	COG1217	gtp-binding protein TYPA
CAG99_RS07860	COG1053	succinate dehydrogenase
CAG99_RS07900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAG99_RS07910	COG1120	ATPase activity
CAG99_RS07935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CAG99_RS07940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CAG99_RS07955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS07975	COG2197	response regulator
CAG99_RS07990	COG4106	trans-aconitate 2-methyltransferase activity
CAG99_RS08005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAG99_RS08015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAG99_RS08085	COG1960	acyl-CoA dehydrogenase activity
CAG99_RS08135	COG0012	GTP binding
CAG99_RS08145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAG99_RS08150	COG1570	exodeoxyribonuclease VII activity
CAG99_RS08155	COG1722	exodeoxyribonuclease VII activity
CAG99_RS08200	COG0114	fumarate hydratase activity
CAG99_RS08205	COG0515	serine threonine protein kinase
CAG99_RS08225	COG1136	(ABC) transporter
CAG99_RS08250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CAG99_RS08255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAG99_RS08260	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CAG99_RS08265	COG4762	Protein conserved in bacteria
CAG99_RS08315	COG2894	cell division
CAG99_RS08350	COG1309	transcriptional regulator
CAG99_RS08365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CAG99_RS08370	COG1331	Highly conserved protein containing a thioredoxin domain
CAG99_RS08385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAG99_RS08395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CAG99_RS08405	COG3903	Transcriptional regulator
CAG99_RS08405	COG3629	intracellular signal transduction
CAG99_RS08420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CAG99_RS08425	COG2255	four-way junction helicase activity
CAG99_RS08440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAG99_RS08455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAG99_RS08465	COG0740	serine-type endopeptidase activity
CAG99_RS08470	COG0740	serine-type endopeptidase activity
CAG99_RS08485	COG3540	Alkaline phosphatase
CAG99_RS08495	COG0667	Aldo Keto reductase
CAG99_RS08520	COG0651	ATP synthesis coupled electron transport
CAG99_RS08525	COG1006	Multisubunit Na H antiporter MnhC subunit
CAG99_RS08530	COG2111	Na H antiporter
CAG99_RS08530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAG99_RS08545	COG1376	ErfK ybiS ycfS ynhG family protein
CAG99_RS08560	COG2986	histidine ammonia-lyase
CAG99_RS08570	COG1024	Enoyl-CoA hydratase
CAG99_RS08575	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CAG99_RS08585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAG99_RS08595	COG0424	maF-like protein
CAG99_RS08605	COG4770	biotin carboxylase activity
CAG99_RS08630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAG99_RS08645	COG0702	epimerase
CAG99_RS08650	COG3631	Ketosteroid isomerase-related protein
CAG99_RS08670	COG1595	DNA-templated transcription, initiation
CAG99_RS08680	COG1012	belongs to the aldehyde dehydrogenase family
CAG99_RS08690	COG1595	DNA-templated transcription, initiation
CAG99_RS08695	COG0745	RESPONSE REGULATOR receiver
CAG99_RS08700	COG2205	protein histidine kinase activity
CAG99_RS08720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAG99_RS08725	COG0583	DNA-binding transcription factor activity
CAG99_RS08730	COG2814	Major facilitator Superfamily
CAG99_RS08735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAG99_RS08745	COG2239	Acts as a magnesium transporter
CAG99_RS08760	COG1079	Belongs to the binding-protein-dependent transport system permease family
CAG99_RS08765	COG4603	Belongs to the binding-protein-dependent transport system permease family
CAG99_RS08770	COG3845	ABC transporter
CAG99_RS08775	COG1744	ABC transporter substrate-binding protein PnrA-like
CAG99_RS08780	COG1473	amidohydrolase
CAG99_RS08780	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CAG99_RS08795	COG2089	acid synthase
CAG99_RS08800	COG1083	cytidylyl-transferase
CAG99_RS08820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CAG99_RS08825	COG2009	succinate dehydrogenase
CAG99_RS08840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CAG99_RS08845	COG2264	protein methyltransferase activity
CAG99_RS08850	COG0277	FAD linked oxidase domain protein
CAG99_RS08870	COG1408	metallophosphoesterase
CAG99_RS08875	COG1686	Belongs to the peptidase S11 family
CAG99_RS08880	COG1295	ribonuclease BN
CAG99_RS08890	COG0180	Tryptophanyl-tRNA synthetase
CAG99_RS08895	COG0039	L-malate dehydrogenase activity
CAG99_RS08910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAG99_RS08920	COG0138	bifunctional purine biosynthesis protein purh
CAG99_RS08950	COG0045	succinate-CoA ligase (ADP-forming) activity
CAG99_RS08955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CAG99_RS08960	COG0739	heme binding
CAG99_RS08985	COG0791	NLP P60 protein
CAG99_RS09040	COG2197	response regulator
CAG99_RS09045	COG0519	Catalyzes the synthesis of GMP from XMP
CAG99_RS09045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAG99_RS09080	COG1012	belongs to the aldehyde dehydrogenase family
CAG99_RS09090	COG0515	serine threonine protein kinase
CAG99_RS09095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CAG99_RS09100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CAG99_RS09110	COG0516	GMP reductase activity
CAG99_RS09120	COG1595	DNA-templated transcription, initiation
CAG99_RS09125	COG2197	response regulator
CAG99_RS09145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CAG99_RS09150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAG99_RS09155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAG99_RS09160	COG0726	polysaccharide deacetylase
CAG99_RS09175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAG99_RS09195	COG0802	atpase or kinase
CAG99_RS09205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAG99_RS09215	COG0736	holo-[acyl-carrier-protein] synthase activity
CAG99_RS09220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAG99_RS09225	COG1072	(Pantothenic acid kinase))
CAG99_RS09230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAG99_RS09235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CAG99_RS09240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CAG99_RS09245	COG0488	(ABC) transporter
CAG99_RS09255	COG0101	tRNA pseudouridine synthase activity
CAG99_RS09265	COG0203	ribosomal protein L17
CAG99_RS09270	COG0202	RNA polymerase activity
CAG99_RS09275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CAG99_RS09280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CAG99_RS09285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CAG99_RS09290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CAG99_RS09295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CAG99_RS09305	COG0563	adenylate kinase activity
CAG99_RS09315	COG0200	Binds to the 23S rRNA
CAG99_RS09320	COG1841	ribosomal large subunit assembly
CAG99_RS09325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CAG99_RS09330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAG99_RS09335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CAG99_RS09340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAG99_RS09345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CAG99_RS09350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CAG99_RS09355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CAG99_RS09360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CAG99_RS09365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAG99_RS09370	COG0255	Belongs to the universal ribosomal protein uL29 family
CAG99_RS09375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CAG99_RS09380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CAG99_RS09385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CAG99_RS09390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CAG99_RS09395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CAG99_RS09400	COG0089	rRNA binding
CAG99_RS09405	COG0088	Forms part of the polypeptide exit tunnel
CAG99_RS09410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAG99_RS09415	COG0051	transcription antitermination factor activity, RNA binding
CAG99_RS09435	COG3275	phosphorelay sensor kinase activity
CAG99_RS09445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAG99_RS09460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAG99_RS09465	COG0049	tRNA binding
CAG99_RS09470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAG99_RS09475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CAG99_RS09480	COG0085	RNA polymerase activity
CAG99_RS09485	COG0222	ribosome binding
CAG99_RS09490	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAG99_RS09500	COG0081	regulation of translation
CAG99_RS09505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CAG99_RS09520	COG0250	Participates in transcription elongation, termination and antitermination
CAG99_RS09525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAG99_RS09535	COG0436	Aminotransferase
CAG99_RS09540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAG99_RS09545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAG99_RS09555	COG2030	dehydratase
CAG99_RS09560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAG99_RS09585	COG0702	epimerase
CAG99_RS09600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAG99_RS09605	COG4608	Belongs to the ABC transporter superfamily
CAG99_RS09610	COG0444	Belongs to the ABC transporter superfamily
CAG99_RS09620	COG0747	negative chemotaxis
CAG99_RS09625	COG2186	Transcriptional regulator
CAG99_RS09695	COG0640	Transcriptional regulator
CAG99_RS09750	COG3507	Belongs to the glycosyl hydrolase 43 family
CAG99_RS09765	COG3864	Putative metallopeptidase domain
CAG99_RS09770	COG0714	Associated with various cellular activities
CAG99_RS09785	COG2814	Major facilitator Superfamily
CAG99_RS09815	COG0254	rRNA binding
CAG99_RS09820	COG0019	diaminopimelate decarboxylase activity
CAG99_RS09825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAG99_RS09830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAG99_RS09840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAG99_RS09845	COG1121	(ABC) transporter
CAG99_RS09865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAG99_RS09870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAG99_RS09880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CAG99_RS09885	COG2080	2 iron, 2 sulfur cluster binding
CAG99_RS09925	COG0659	secondary active sulfate transmembrane transporter activity
CAG99_RS09965	COG1404	Belongs to the peptidase S8 family
CAG99_RS09980	COG3547	Transposase (IS116 IS110 IS902 family)
CAG99_RS09990	COG1396	sequence-specific DNA binding
CAG99_RS09995	COG2890	protein-(glutamine-N5) methyltransferase activity
CAG99_RS10000	COG2318	DinB family
CAG99_RS10005	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS10010	COG0583	DNA-binding transcription factor activity
CAG99_RS10110	COG0604	alcohol dehydrogenase
CAG99_RS10235	COG1857	crispr-associated protein
CAG99_RS10250	COG1518	maintenance of DNA repeat elements
CAG99_RS10255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAG99_RS10275	COG1132	(ABC) transporter
CAG99_RS10310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAG99_RS10315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAG99_RS10320	COG1518	maintenance of DNA repeat elements
CAG99_RS10380	COG1228	amidohydrolase
CAG99_RS10395	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAG99_RS10400	COG1129	ABC transporter
CAG99_RS10415	COG3938	Belongs to the proline racemase family
CAG99_RS10420	COG1802	Transcriptional regulator
CAG99_RS10445	COG1136	(ABC) transporter
CAG99_RS10455	COG1666	GTP binding
CAG99_RS10460	COG0598	Magnesium transport protein CorA
CAG99_RS10470	COG3304	Inner membrane component domain
CAG99_RS10475	COG0501	Belongs to the peptidase M48B family
CAG99_RS10480	COG1007	ATP synthesis coupled electron transport
CAG99_RS10490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAG99_RS10495	COG0713	ATP synthesis coupled electron transport
CAG99_RS10500	COG0839	Belongs to the complex I subunit 6 family
CAG99_RS10505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAG99_RS10510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAG99_RS10515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAG99_RS10520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAG99_RS10525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAG99_RS10530	COG4585	Histidine kinase
CAG99_RS10535	COG4585	Histidine kinase
CAG99_RS10540	COG2197	response regulator
CAG99_RS10545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CAG99_RS10545	COG0674	pyruvate-flavodoxin oxidoreductase activity
CAG99_RS10550	COG1013	pyruvate-flavodoxin oxidoreductase activity
CAG99_RS10570	COG2124	cytochrome p450
CAG99_RS10585	COG0604	alcohol dehydrogenase
CAG99_RS10585	COG3321	synthase
CAG99_RS10585	COG0604	alcohol dehydrogenase
CAG99_RS10585	COG3321	synthase
CAG99_RS10595	COG1309	transcriptional regulator
CAG99_RS10635	COG0142	geranyltranstransferase activity
CAG99_RS10645	COG1007	ATP synthesis coupled electron transport
CAG99_RS10655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAG99_RS10660	COG0713	ATP synthesis coupled electron transport
CAG99_RS10670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAG99_RS10675	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAG99_RS10680	COG1034	ATP synthesis coupled electron transport
CAG99_RS10685	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CAG99_RS10695	COG0649	NAD binding
CAG99_RS10700	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAG99_RS10705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAG99_RS10730	COG2226	methyltransferase
CAG99_RS10745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CAG99_RS10750	COG0515	serine threonine protein kinase
CAG99_RS10750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAG99_RS10755	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CAG99_RS10760	COG1278	Cold shock
CAG99_RS10795	COG1301	dicarboxylic acid transport
CAG99_RS10810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CAG99_RS10820	COG0163	prenyltransferase activity
CAG99_RS10830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAG99_RS10835	COG0515	serine threonine protein kinase
CAG99_RS10835	COG2815	serine threonine protein kinase
CAG99_RS10840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAG99_RS10885	COG1609	Transcriptional regulator
CAG99_RS10890	COG0745	RESPONSE REGULATOR receiver
CAG99_RS10910	COG2897	thiosulfate sulfurtransferase activity
CAG99_RS10925	COG3485	protocatechuate 3,4-dioxygenase
CAG99_RS10945	COG0354	folic acid binding
CAG99_RS10950	COG1490	D-aminoacyl-tRNA deacylase activity
CAG99_RS10965	COG4552	Acetyltransferase involved in intracellular survival and related
CAG99_RS10980	COG0546	phosphoglycolate phosphatase activity
CAG99_RS10990	COG2409	Drug exporters of the RND superfamily
CAG99_RS10995	COG2197	response regulator
CAG99_RS11010	COG4585	Histidine kinase
CAG99_RS11045	COG2226	methyltransferase
CAG99_RS11060	COG1733	regulation of RNA biosynthetic process
CAG99_RS11090	COG1392	Phosphate transport regulator
CAG99_RS11100	COG1404	Belongs to the peptidase S8 family
CAG99_RS11105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAG99_RS11125	COG1937	Protein conserved in bacteria
CAG99_RS11165	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CAG99_RS11175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAG99_RS11180	COG1333	cytochrome c biogenesis protein
CAG99_RS11185	COG0785	Cytochrome C biogenesis protein
CAG99_RS11195	COG0406	alpha-ribazole phosphatase activity
CAG99_RS11200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAG99_RS11225	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CAG99_RS11235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CAG99_RS11245	COG0113	porphobilinogen synthase activity
CAG99_RS11250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAG99_RS11250	COG1648	precorrin-2 dehydrogenase activity
CAG99_RS11255	COG0181	hydroxymethylbilane synthase activity
CAG99_RS11260	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CAG99_RS11265	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CAG99_RS11310	COG0123	including yeast histone deacetylase and acetoin utilization protein
CAG99_RS11340	COG4555	ABC transporter
CAG99_RS11345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CAG99_RS11375	COG0129	dihydroxy-acid dehydratase activity
CAG99_RS11385	COG0248	Ppx GppA phosphatase
CAG99_RS11390	COG1082	Xylose isomerase domain protein TIM barrel
CAG99_RS11405	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CAG99_RS11455	COG0519	Catalyzes the synthesis of GMP from XMP
CAG99_RS11495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CAG99_RS11515	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CAG99_RS11525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CAG99_RS11530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CAG99_RS11540	COG2197	response regulator
CAG99_RS11555	COG0649	NAD binding
CAG99_RS11610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CAG99_RS11615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CAG99_RS11625	COG0517	IMP dehydrogenase activity
CAG99_RS11625	COG1125	glycine betaine transport
CAG99_RS11635	COG1174	glycine betaine transport
CAG99_RS11650	COG0302	gtp cyclohydrolase
CAG99_RS11665	COG0037	tRNA processing
CAG99_RS11675	COG2027	D-alanyl-D-alanine carboxypeptidase
CAG99_RS11680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CAG99_RS11730	COG0254	rRNA binding
CAG99_RS11750	COG1132	(ABC) transporter
CAG99_RS11755	COG1077	Cell shape determining protein MreB Mrl
CAG99_RS11770	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
CAG99_RS11775	COG1959	2 iron, 2 sulfur cluster binding
CAG99_RS11780	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS11785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAG99_RS11790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAG99_RS11810	COG1378	Sugar-specific transcriptional regulator TrmB
CAG99_RS11835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAG99_RS11855	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAG99_RS11870	COG3540	Alkaline phosphatase
CAG99_RS11900	COG1191	sigma factor activity
CAG99_RS11915	COG0437	4 iron, 4 sulfur cluster binding
CAG99_RS12040	COG1674	ftsk spoiiie
CAG99_RS12050	COG1404	Belongs to the peptidase S8 family
CAG99_RS12075	COG1733	regulation of RNA biosynthetic process
CAG99_RS12095	COG4585	Histidine kinase
CAG99_RS12100	COG2197	response regulator
CAG99_RS12115	COG2226	methyltransferase
CAG99_RS12125	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CAG99_RS12145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAG99_RS12165	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CAG99_RS12175	COG1819	glycosyl
CAG99_RS12220	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CAG99_RS12220	COG1672	PFAM Archaeal ATPase
CAG99_RS12265	COG0583	DNA-binding transcription factor activity
CAG99_RS12285	COG0667	Aldo Keto reductase
CAG99_RS12340	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS12370	COG1643	Atp-dependent helicase
CAG99_RS12390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CAG99_RS12400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAG99_RS12430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAG99_RS12435	COG0047	phosphoribosylformylglycinamidine synthase activity
CAG99_RS12440	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAG99_RS12475	COG2197	response regulator
CAG99_RS12480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CAG99_RS12495	COG0151	Belongs to the GarS family
CAG99_RS12510	COG1802	Transcriptional regulator
CAG99_RS12520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAG99_RS12530	COG1131	(ABC) transporter
CAG99_RS12535	COG3559	Exporter of polyketide antibiotics
CAG99_RS12555	COG0191	fructose-bisphosphate aldolase activity
CAG99_RS12560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CAG99_RS12575	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CAG99_RS12595	COG0542	response to heat
CAG99_RS12615	COG0671	phosphoesterase, PA-phosphatase related
CAG99_RS12630	COG1192	Involved in chromosome partitioning
CAG99_RS12635	COG0789	Transcriptional regulator
CAG99_RS12640	COG0484	heat shock protein binding
CAG99_RS12645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAG99_RS12650	COG0443	Heat shock 70 kDa protein
CAG99_RS12655	COG2770	Histidine kinase
CAG99_RS12655	COG2208	phosphoserine phosphatase activity
CAG99_RS12670	COG1316	TRANSCRIPTIONal
CAG99_RS12680	COG0247	lactate metabolic process
CAG99_RS12680	COG2181	nitrate reductase activity
CAG99_RS12690	COG0717	Belongs to the dCTP deaminase family
CAG99_RS12770	COG2304	oxidoreductase activity
CAG99_RS12785	COG1136	(ABC) transporter
CAG99_RS12800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAG99_RS12805	COG0110	maltose O-acetyltransferase activity
CAG99_RS12835	COG3401	FG-GAP repeat protein
CAG99_RS12865	COG0640	Transcriptional regulator
CAG99_RS12880	COG0702	epimerase
CAG99_RS12885	COG0436	Aminotransferase
CAG99_RS12915	COG2234	aminopeptidase activity
CAG99_RS12930	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CAG99_RS12940	COG0590	tRNA wobble adenosine to inosine editing
CAG99_RS12950	COG3903	Transcriptional regulator
CAG99_RS12950	COG3629	intracellular signal transduction
CAG99_RS12960	COG1191	sigma factor activity
CAG99_RS12965	COG1191	sigma factor activity
CAG99_RS13055	COG0318	PFAM AMP-dependent synthetase and ligase
CAG99_RS13060	COG1595	DNA-templated transcription, initiation
CAG99_RS13085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAG99_RS13100	COG0653	protein targeting
CAG99_RS13115	COG0006	proline dipeptidase activity
CAG99_RS13120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAG99_RS13130	COG0586	Pfam SNARE associated Golgi protein
CAG99_RS13135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAG99_RS13145	COG2172	sigma factor antagonist activity
CAG99_RS13160	COG1999	signal sequence binding
CAG99_RS13170	COG2372	response to copper ion
CAG99_RS13170	COG1276	copper resistance
CAG99_RS13175	COG2837	iron assimilation
CAG99_RS13185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAG99_RS13205	COG2226	methyltransferase
CAG99_RS13215	COG1396	sequence-specific DNA binding
CAG99_RS13250	COG1131	(ABC) transporter
CAG99_RS13265	COG0561	phosphatase activity
CAG99_RS13275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CAG99_RS13280	COG1609	Transcriptional regulator
CAG99_RS13285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAG99_RS13290	COG1271	oxidase subunit
CAG99_RS13295	COG1294	oxidase, subunit
CAG99_RS13300	COG4988	ABC transporter
CAG99_RS13320	COG0438	transferase activity, transferring glycosyl groups
CAG99_RS13340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAG99_RS13345	COG0438	transferase activity, transferring glycosyl groups
CAG99_RS13355	COG1716	ATPase activity
CAG99_RS13360	COG1716	ATPase activity
CAG99_RS13370	COG0772	Belongs to the SEDS family
CAG99_RS13380	COG0515	serine threonine protein kinase
CAG99_RS13395	COG0705	Rhomboid family
CAG99_RS13420	COG3764	Sortase (surface protein transpeptidase)
CAG99_RS13425	COG3764	Sortase (surface protein transpeptidase)
CAG99_RS13530	COG0582	viral genome integration into host DNA
CAG99_RS13545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CAG99_RS13550	COG0187	DNA topoisomerase II activity
CAG99_RS13555	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CAG99_RS13560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CAG99_RS13565	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CAG99_RS13570	COG0592	DNA-directed DNA polymerase activity
CAG99_RS13575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAG99_RS13580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CAG99_RS13585	COG0594	ribonuclease P activity
CAG99_RS13590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAG99_RS13595	COG0706	membrane insertase activity
CAG99_RS13605	COG0357	Ribosomal RNA small subunit methyltransferase G
CAG99_RS13610	COG1192	Involved in chromosome partitioning
CAG99_RS13620	COG3118	belongs to the thioredoxin family
CAG99_RS13625	COG0492	ferredoxin-NADP+ reductase activity
CAG99_RS13635	COG1595	DNA-templated transcription, initiation
CAG99_RS13655	COG0617	tRNA 3'-terminal CCA addition
CAG99_RS13670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAG99_RS13700	COG0360	Binds together with S18 to 16S ribosomal RNA
CAG99_RS13705	COG0629	single-stranded DNA binding
CAG99_RS13710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAG99_RS13715	COG0359	binds to the 23S rRNA
CAG99_RS13725	COG0305	Participates in initiation and elongation during chromosome replication
CAG99_RS13760	COG0626	cystathionine gamma-synthase activity
CAG99_RS13770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAG99_RS13775	COG1950	PFAM Membrane protein of
CAG99_RS13780	COG0662	Cupin 2, conserved barrel domain protein
CAG99_RS13795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CAG99_RS13805	COG2304	oxidoreductase activity
CAG99_RS13825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAG99_RS13830	COG1733	regulation of RNA biosynthetic process
CAG99_RS13840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAG99_RS13855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAG99_RS13860	COG2151	metal-sulfur cluster biosynthetic enzyme
CAG99_RS13865	COG3460	Phenylacetate-CoA oxygenase
CAG99_RS13870	COG3396	Phenylacetate-CoA oxygenase
CAG99_RS13900	COG1309	transcriptional regulator
CAG99_RS13930	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CAG99_RS13935	COG1522	sequence-specific DNA binding
CAG99_RS13945	COG0022	dehydrogenase e1 component
CAG99_RS13950	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAG99_RS13955	COG0746	molybdenum cofactor guanylyltransferase activity
CAG99_RS13960	COG0303	'Molybdopterin
CAG99_RS13965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAG99_RS13970	COG0702	epimerase
CAG99_RS14035	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAG99_RS14040	COG0022	dehydrogenase e1 component
CAG99_RS14060	COG0515	serine threonine protein kinase
CAG99_RS14065	COG0515	serine threonine protein kinase
CAG99_RS14075	COG1362	aminopeptidase activity
CAG99_RS14080	COG1960	acyl-CoA dehydrogenase activity
CAG99_RS14090	COG1741	Belongs to the pirin family
CAG99_RS14105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CAG99_RS14135	COG1309	transcriptional regulator
CAG99_RS14140	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS14160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAG99_RS14180	COG1595	DNA-templated transcription, initiation
CAG99_RS14205	COG1672	PFAM Archaeal ATPase
CAG99_RS14205	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CAG99_RS14265	COG1309	transcriptional regulator
CAG99_RS14270	COG0702	epimerase
CAG99_RS14280	COG0604	alcohol dehydrogenase
CAG99_RS14280	COG3321	synthase
CAG99_RS14280	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS14290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAG99_RS14300	COG1793	dna ligase
CAG99_RS14310	COG2949	membrane
CAG99_RS14325	COG1216	Glycosyl transferase, family 2
CAG99_RS14360	COG1045	serine acetyltransferase
CAG99_RS14365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAG99_RS14375	COG0435	Glutathione S-transferase
CAG99_RS14385	COG0726	polysaccharide deacetylase
CAG99_RS14490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CAG99_RS14495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAG99_RS14515	COG1595	DNA-templated transcription, initiation
CAG99_RS14550	COG0003	Pfam Anion-transporting ATPase
CAG99_RS14565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAG99_RS14575	COG1408	metallophosphoesterase
CAG99_RS14625	COG2188	Transcriptional regulator
CAG99_RS14665	COG0582	viral genome integration into host DNA
CAG99_RS14675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAG99_RS14690	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CAG99_RS14700	COG0028	Belongs to the TPP enzyme family
CAG99_RS14715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAG99_RS14745	COG2267	carboxylic ester hydrolase activity
CAG99_RS14755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAG99_RS14820	COG1205	dead DEAH box helicase
CAG99_RS14820	COG1111	helicase
CAG99_RS14825	COG1366	Belongs to the anti-sigma-factor antagonist family
CAG99_RS14830	COG2172	sigma factor antagonist activity
CAG99_RS14850	COG1754	DNA topoisomerase type I activity
CAG99_RS14850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAG99_RS14855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAG99_RS14860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CAG99_RS14905	COG1674	ftsk spoiiie
CAG99_RS15000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAG99_RS15005	COG0604	alcohol dehydrogenase
CAG99_RS15020	COG2223	nitrite transmembrane transporter activity
CAG99_RS15025	COG0243	molybdopterin cofactor binding
CAG99_RS15030	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAG99_RS15035	COG2146	nitrite reductase [NAD(P)H] activity
CAG99_RS15035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAG99_RS15045	COG0655	NAD(P)H dehydrogenase (quinone) activity
CAG99_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS15070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAG99_RS15080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAG99_RS15085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAG99_RS15100	COG3903	Transcriptional regulator
CAG99_RS15100	COG3629	intracellular signal transduction
CAG99_RS15125	COG1414	Transcriptional regulator
CAG99_RS15135	COG4106	trans-aconitate 2-methyltransferase activity
CAG99_RS15140	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CAG99_RS15185	COG0513	Belongs to the DEAD box helicase family
CAG99_RS15225	COG1733	regulation of RNA biosynthetic process
CAG99_RS15230	COG0741	lytic transglycosylase activity
CAG99_RS15230	COG0739	heme binding
CAG99_RS15230	COG1196	nuclear chromosome segregation
CAG99_RS15235	COG0667	Aldo Keto reductase
CAG99_RS15260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAG99_RS15270	COG0579	oxidoreductase
CAG99_RS15325	COG1357	PFAM Pentapeptide repeats (8 copies)
CAG99_RS15330	COG0789	Transcriptional regulator
CAG99_RS15335	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CAG99_RS15345	COG0737	Belongs to the 5'-nucleotidase family
CAG99_RS15345	COG1525	nuclease
CAG99_RS15345	COG4085	toxin activity
CAG99_RS15350	COG0456	acetyltransferase
CAG99_RS15355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CAG99_RS15360	COG0406	alpha-ribazole phosphatase activity
CAG99_RS15360	COG0494	nUDIX hydrolase
CAG99_RS15370	COG0438	transferase activity, transferring glycosyl groups
CAG99_RS15385	COG0588	phosphoglycerate mutase activity
CAG99_RS15400	COG5002	protein histidine kinase activity
CAG99_RS15425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAG99_RS15430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CAG99_RS15440	COG0215	cysteine-tRNA ligase activity
CAG99_RS15445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAG99_RS15455	COG1595	DNA-templated transcription, initiation
CAG99_RS15465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CAG99_RS15475	COG3842	ATPase activity
CAG99_RS15495	COG0789	Transcriptional regulator
CAG99_RS15525	COG5001	Diguanylate cyclase
CAG99_RS15525	COG3300	MHYT domain
CAG99_RS15545	COG0191	fructose-bisphosphate aldolase activity
CAG99_RS15550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CAG99_RS15555	COG1940	carbohydrate kinase activity
CAG99_RS15560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAG99_RS15575	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CAG99_RS15580	COG0463	Glycosyl transferase, family 2
CAG99_RS15595	COG1278	Cold shock
CAG99_RS15600	COG0459	protein refolding
CAG99_RS15615	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CAG99_RS15620	COG1737	Transcriptional regulator
CAG99_RS15650	COG3173	Aminoglycoside phosphotransferase
CAG99_RS15655	COG3973	AAA domain
CAG99_RS15680	COG1733	regulation of RNA biosynthetic process
CAG99_RS15690	COG1061	Type III restriction enzyme res subunit
CAG99_RS15695	COG0583	DNA-binding transcription factor activity
CAG99_RS15735	COG0745	RESPONSE REGULATOR receiver
CAG99_RS15755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAG99_RS15760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAG99_RS15765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CAG99_RS15770	COG1120	ATPase activity
CAG99_RS15775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS15780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS15795	COG1278	Cold shock
CAG99_RS15800	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CAG99_RS15805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CAG99_RS15815	COG2814	Major facilitator Superfamily
CAG99_RS15840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAG99_RS15845	COG1733	regulation of RNA biosynthetic process
CAG99_RS15880	COG0667	Aldo Keto reductase
CAG99_RS15930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CAG99_RS15965	COG0247	lactate metabolic process
CAG99_RS15965	COG0277	FAD linked oxidase domain protein
CAG99_RS15970	COG4948	Mandelate Racemase Muconate Lactonizing
CAG99_RS15990	COG0259	pyridoxamine-phosphate oxidase activity
CAG99_RS15995	COG5002	protein histidine kinase activity
CAG99_RS15995	COG5001	Diguanylate cyclase
CAG99_RS15995	COG3447	MASE1 domain protein
CAG99_RS16000	COG4821	SIS domain
CAG99_RS16070	COG1366	Belongs to the anti-sigma-factor antagonist family
CAG99_RS16080	COG2072	flavoprotein involved in K transport
CAG99_RS16090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAG99_RS16090	COG0515	serine threonine protein kinase
CAG99_RS16125	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CAG99_RS16205	COG2272	Belongs to the type-B carboxylesterase lipase family
CAG99_RS16235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAG99_RS16245	COG0315	cyclic pyranopterin monophosphate synthase activity
CAG99_RS16255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CAG99_RS16260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAG99_RS16270	COG3263	regulation of cellular component size
CAG99_RS16280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CAG99_RS16290	COG1970	mechanosensitive ion channel activity
CAG99_RS16300	COG3191	aminopeptidase activity
CAG99_RS16305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAG99_RS16305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAG99_RS16315	COG1349	DNA-binding transcription factor activity
CAG99_RS16340	COG0772	Belongs to the SEDS family
CAG99_RS16345	COG1473	amidohydrolase
CAG99_RS16350	COG3572	ergothioneine biosynthetic process
CAG99_RS16355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAG99_RS16365	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CAG99_RS16410	COG0477	Major facilitator Superfamily
CAG99_RS16420	COG1846	Transcriptional regulator
CAG99_RS16425	COG1764	response to oxidative stress
CAG99_RS16445	COG0129	dihydroxy-acid dehydratase activity
CAG99_RS16485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAG99_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS16520	COG2072	flavoprotein involved in K transport
CAG99_RS16525	COG2267	carboxylic ester hydrolase activity
CAG99_RS16530	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS16550	COG4946	Tricorn protease homolog
CAG99_RS16550	COG0793	Belongs to the peptidase S41A family
CAG99_RS16555	COG2409	Drug exporters of the RND superfamily
CAG99_RS16560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAG99_RS16595	COG0084	hydrolase, TatD family'
CAG99_RS16600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAG99_RS16625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CAG99_RS16630	COG0488	(ABC) transporter
CAG99_RS16655	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CAG99_RS16660	COG2197	response regulator
CAG99_RS16675	COG1309	transcriptional regulator
CAG99_RS16685	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CAG99_RS16720	COG2226	methyltransferase
CAG99_RS16730	COG0193	aminoacyl-tRNA hydrolase activity
CAG99_RS16735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CAG99_RS16740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAG99_RS16745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAG99_RS16795	COG1136	(ABC) transporter
CAG99_RS16800	COG0577	efflux transmembrane transporter activity
CAG99_RS16815	COG0513	Belongs to the DEAD box helicase family
CAG99_RS16820	COG1278	Cold shock
CAG99_RS16900	COG0738	Major facilitator superfamily
CAG99_RS16905	COG3226	Transcriptional regulator
CAG99_RS16930	COG4948	Mandelate Racemase Muconate Lactonizing
CAG99_RS16965	COG4585	Histidine kinase
CAG99_RS16985	COG0148	phosphopyruvate hydratase activity
CAG99_RS17015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAG99_RS17020	COG0577	efflux transmembrane transporter activity
CAG99_RS17025	COG1136	(ABC) transporter
CAG99_RS17085	COG0183	Belongs to the thiolase family
CAG99_RS17090	COG2755	lipolytic protein G-D-S-L family
CAG99_RS17110	COG0019	diaminopimelate decarboxylase activity
CAG99_RS17115	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CAG99_RS17130	COG1228	amidohydrolase
CAG99_RS17150	COG1191	sigma factor activity
CAG99_RS17155	COG1366	Belongs to the anti-sigma-factor antagonist family
CAG99_RS17165	COG0745	RESPONSE REGULATOR receiver
CAG99_RS17170	COG5002	protein histidine kinase activity
CAG99_RS17195	COG1196	nuclear chromosome segregation
CAG99_RS17195	COG0741	lytic transglycosylase activity
CAG99_RS17195	COG0739	heme binding
CAG99_RS17210	COG1309	transcriptional regulator
CAG99_RS17215	COG2890	protein-(glutamine-N5) methyltransferase activity
CAG99_RS17245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CAG99_RS17250	COG0531	amino acid
CAG99_RS17300	COG1316	TRANSCRIPTIONal
CAG99_RS17305	COG1607	acyl-coa hydrolase
CAG99_RS17330	COG1316	TRANSCRIPTIONal
CAG99_RS17345	COG1316	TRANSCRIPTIONal
CAG99_RS17350	COG0778	Nitroreductase
CAG99_RS17350	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CAG99_RS17355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CAG99_RS17395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAG99_RS17400	COG2835	tetraacyldisaccharide 4'-kinase activity
CAG99_RS17410	COG1482	cell wall glycoprotein biosynthetic process
CAG99_RS17415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CAG99_RS17465	COG0714	Associated with various cellular activities
CAG99_RS17485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CAG99_RS17490	COG0745	RESPONSE REGULATOR receiver
CAG99_RS17495	COG5000	phosphorelay sensor kinase activity
CAG99_RS17495	COG5002	protein histidine kinase activity
CAG99_RS17500	COG0823	Involved in the tonB-independent uptake of proteins
CAG99_RS17510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CAG99_RS17515	COG2197	response regulator
CAG99_RS17520	COG3214	Protein conserved in bacteria
CAG99_RS17525	COG0653	protein targeting
CAG99_RS17545	COG2902	Dehydrogenase
CAG99_RS17555	COG4106	trans-aconitate 2-methyltransferase activity
CAG99_RS17560	COG0395	ABC-type sugar transport system, permease component
CAG99_RS17565	COG1175	transmembrane transport
CAG99_RS17570	COG1653	transport
CAG99_RS17580	COG0515	serine threonine protein kinase
CAG99_RS17585	COG0515	serine threonine protein kinase
CAG99_RS17590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CAG99_RS17605	COG2884	Cell division ATP-binding protein ftsE
CAG99_RS17610	COG2177	Part of the ABC transporter FtsEX involved in
CAG99_RS17615	COG0793	Belongs to the peptidase S41A family
CAG99_RS17620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CAG99_RS17630	COG0768	penicillin binding
CAG99_RS17640	COG0583	DNA-binding transcription factor activity
CAG99_RS17665	COG2223	nitrite transmembrane transporter activity
CAG99_RS17685	COG0776	regulation of translation
CAG99_RS17690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAG99_RS17695	COG1678	Uncharacterized ACR, COG1678
CAG99_RS17715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAG99_RS17735	COG3480	Lon protease (S16) C-terminal proteolytic domain
CAG99_RS17770	COG1335	isochorismatase
CAG99_RS17780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CAG99_RS17790	COG1115	amino acid carrier protein
CAG99_RS17810	COG0772	Belongs to the SEDS family
CAG99_RS17815	COG1234	tRNA 3'-trailer cleavage
CAG99_RS17820	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CAG99_RS17840	COG1175	transmembrane transport
CAG99_RS17845	COG0395	ABC-type sugar transport system, permease component
CAG99_RS17850	COG1874	Beta-galactosidase
CAG99_RS17880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CAG99_RS17910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CAG99_RS17915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAG99_RS17925	COG2733	membrane
CAG99_RS17960	COG1126	abc transporter atp-binding protein
CAG99_RS17965	COG0765	amino acid transport
CAG99_RS17970	COG0765	amino acid transport
CAG99_RS17975	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CAG99_RS17990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAG99_RS18005	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAG99_RS18035	COG3962	Belongs to the TPP enzyme family
CAG99_RS18040	COG3718	enzyme involved in inositol metabolism
CAG99_RS18050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAG99_RS18060	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAG99_RS18075	COG0673	inositol 2-dehydrogenase activity
CAG99_RS18080	COG2188	Transcriptional regulator
CAG99_RS18085	COG0456	acetyltransferase
CAG99_RS18120	COG1404	Belongs to the peptidase S8 family
CAG99_RS18130	COG1595	DNA-templated transcription, initiation
CAG99_RS18135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAG99_RS18135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAG99_RS18145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAG99_RS18150	COG0697	spore germination
CAG99_RS18200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAG99_RS18210	COG3265	gluconokinase activity
CAG99_RS18215	COG2610	gluconate transmembrane transporter activity
CAG99_RS18235	COG1175	transmembrane transport
CAG99_RS18240	COG0395	ABC-type sugar transport system, permease component
CAG99_RS18245	COG3842	ATPase activity
CAG99_RS18250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CAG99_RS18255	COG0569	domain protein
CAG99_RS18260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CAG99_RS18275	COG2255	four-way junction helicase activity
CAG99_RS18295	COG1674	ftsk spoiiie
CAG99_RS18300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAG99_RS18305	COG0789	Transcriptional regulator
CAG99_RS18310	COG1132	(ABC) transporter
CAG99_RS18340	COG2124	cytochrome p450
CAG99_RS18355	COG1819	glycosyl
CAG99_RS18360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAG99_RS18380	COG3321	synthase
CAG99_RS18380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAG99_RS18395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAG99_RS18405	COG0739	heme binding
CAG99_RS18420	COG1131	(ABC) transporter
CAG99_RS18430	COG4585	Histidine kinase
CAG99_RS18435	COG2197	response regulator
CAG99_RS18455	COG3483	tryptophan 2,3-dioxygenase activity
CAG99_RS18465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAG99_RS18470	COG3387	PFAM Glycoside hydrolase 15-related
CAG99_RS18475	COG1335	isochorismatase
CAG99_RS18495	COG1733	regulation of RNA biosynthetic process
CAG99_RS18535	COG0477	Major facilitator Superfamily
CAG99_RS18540	COG4209	transmembrane transport
CAG99_RS18545	COG0395	ABC-type sugar transport system, permease component
CAG99_RS18580	COG0395	ABC-type sugar transport system, permease component
CAG99_RS18585	COG1802	Transcriptional regulator
CAG99_RS18605	COG0667	Aldo Keto reductase
CAG99_RS18635	COG0667	Aldo Keto reductase
CAG99_RS18650	COG1523	belongs to the glycosyl hydrolase 13 family
CAG99_RS18660	COG0693	protein deglycase activity
CAG99_RS18675	COG1797	cobyrinic acid a,c-diamide synthase activity
CAG99_RS18685	COG0366	Alpha amylase catalytic
CAG99_RS18710	COG3266	domain, Protein
CAG99_RS18710	COG4932	domain protein
CAG99_RS18710	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CAG99_RS18720	COG1309	transcriptional regulator
CAG99_RS18750	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS18775	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS18805	COG0640	Transcriptional regulator
CAG99_RS18820	COG0798	PFAM Bile acid sodium symporter
CAG99_RS18825	COG0640	Transcriptional regulator
CAG99_RS18830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAG99_RS18845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CAG99_RS18905	COG1131	(ABC) transporter
CAG99_RS18930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAG99_RS18945	COG0668	transmembrane transport
CAG99_RS18975	COG0243	molybdopterin cofactor binding
CAG99_RS19015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAG99_RS19065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CAG99_RS19100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAG99_RS19120	COG4552	Acetyltransferase involved in intracellular survival and related
CAG99_RS19130	COG0739	heme binding
CAG99_RS19135	COG3594	Acyltransferase
CAG99_RS19155	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAG99_RS19160	COG0740	serine-type endopeptidase activity
CAG99_RS19165	COG0740	serine-type endopeptidase activity
CAG99_RS19170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CAG99_RS19180	COG0525	valine-tRNA ligase activity
CAG99_RS19185	COG0285	dihydrofolate synthase activity
CAG99_RS19195	COG0105	UTP biosynthetic process
CAG99_RS19200	COG1077	Cell shape determining protein MreB Mrl
CAG99_RS19215	COG0768	penicillin binding
CAG99_RS19220	COG0772	Belongs to the SEDS family
CAG99_RS19265	COG0640	Transcriptional regulator
CAG99_RS19270	COG0640	Transcriptional regulator
CAG99_RS19275	COG2814	Major facilitator Superfamily
CAG99_RS19290	COG1530	ribonuclease E activity
CAG99_RS19295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAG99_RS19300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CAG99_RS19305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CAG99_RS19320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CAG99_RS19325	COG3594	Acyltransferase
CAG99_RS19335	COG0477	Major facilitator Superfamily
CAG99_RS19350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CAG99_RS19360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CAG99_RS19375	COG0501	Belongs to the peptidase M48B family
CAG99_RS19380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CAG99_RS19395	COG0588	phosphoglycerate mutase activity
CAG99_RS19420	COG1619	proteins homologs of microcin C7 resistance protein MccF
CAG99_RS19460	COG4221	oxidoreductase activity
CAG99_RS19515	COG1203	CRISPR-associated helicase, Cas3
CAG99_RS19525	COG1518	maintenance of DNA repeat elements
CAG99_RS19530	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CAG99_RS19560	COG3401	FG-GAP repeat protein
CAG99_RS19565	COG0406	alpha-ribazole phosphatase activity
CAG99_RS19570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAG99_RS19585	COG2910	NAD(P)H-binding
CAG99_RS19590	COG1733	regulation of RNA biosynthetic process
CAG99_RS19610	COG3973	AAA domain
CAG99_RS19625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CAG99_RS19635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CAG99_RS19660	COG2223	nitrite transmembrane transporter activity
CAG99_RS19665	COG1216	Glycosyl transferase, family 2
CAG99_RS19680	COG1690	Belongs to the RtcB family
CAG99_RS19695	COG3321	synthase
CAG99_RS19695	COG0604	alcohol dehydrogenase
CAG99_RS19715	COG3321	synthase
CAG99_RS19715	COG0604	alcohol dehydrogenase
CAG99_RS19720	COG0604	alcohol dehydrogenase
CAG99_RS19720	COG3321	synthase
CAG99_RS19730	COG2267	carboxylic ester hydrolase activity
CAG99_RS19735	COG0604	alcohol dehydrogenase
CAG99_RS19735	COG3321	synthase
CAG99_RS19740	COG2124	cytochrome p450
CAG99_RS19745	COG0477	Major facilitator Superfamily
CAG99_RS19755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAG99_RS19770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAG99_RS19775	COG3321	synthase
CAG99_RS19775	COG0604	alcohol dehydrogenase
CAG99_RS19790	COG2022	thiamine diphosphate biosynthetic process
CAG99_RS19790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAG99_RS19800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAG99_RS19805	COG2197	response regulator
CAG99_RS19810	COG0644	oxidoreductase
CAG99_RS19825	COG4221	oxidoreductase activity
CAG99_RS19825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAG99_RS19825	COG3321	synthase
CAG99_RS19825	COG0300	oxidoreductase activity
CAG99_RS19835	COG0300	oxidoreductase activity
CAG99_RS19840	COG2124	cytochrome p450
CAG99_RS19845	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CAG99_RS19850	COG3903	Transcriptional regulator
CAG99_RS19850	COG3629	intracellular signal transduction
CAG99_RS19880	COG0110	maltose O-acetyltransferase activity
CAG99_RS19895	COG1309	transcriptional regulator
CAG99_RS19905	COG0586	Pfam SNARE associated Golgi protein
CAG99_RS19915	COG3851	Histidine kinase
CAG99_RS19920	COG2197	response regulator
CAG99_RS19925	COG3401	FG-GAP repeat protein
CAG99_RS19935	COG2197	response regulator
CAG99_RS19940	COG4585	Histidine kinase
CAG99_RS19960	COG1063	alcohol dehydrogenase
CAG99_RS19970	COG3509	depolymerase
CAG99_RS19995	COG0488	(ABC) transporter
CAG99_RS20000	COG0488	(ABC) transporter
CAG99_RS20015	COG0495	leucyl-tRNA aminoacylation
CAG99_RS20025	COG1307	EDD domain protein, DegV family
CAG99_RS20035	COG2333	competence protein COMEC
CAG99_RS20035	COG0658	competence protein
CAG99_RS20040	COG2226	methyltransferase
CAG99_RS20075	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS20080	COG0488	(ABC) transporter
CAG99_RS20095	COG2124	cytochrome p450
CAG99_RS20170	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CAG99_RS20190	COG0268	Binds directly to 16S ribosomal RNA
CAG99_RS20195	COG0481	GTPase activity
CAG99_RS20220	COG1420	regulation of RNA biosynthetic process
CAG99_RS20225	COG0484	heat shock protein binding
CAG99_RS20285	COG0733	neurotransmitter:sodium symporter activity
CAG99_RS20290	COG0537	adenosine 5'-monophosphoramidase activity
CAG99_RS20295	COG1234	tRNA 3'-trailer cleavage
CAG99_RS20300	COG2318	DinB family
CAG99_RS20305	COG1486	melibiose metabolic process
CAG99_RS20320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CAG99_RS20340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAG99_RS20345	COG0842	Transport permease protein
CAG99_RS20345	COG1129	ABC transporter
CAG99_RS20360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAG99_RS20370	COG1381	Involved in DNA repair and RecF pathway recombination
CAG99_RS20375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAG99_RS20385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAG99_RS20390	COG1121	(ABC) transporter
CAG99_RS20400	COG0423	glycine-tRNA ligase activity
CAG99_RS20410	COG0667	Aldo Keto reductase
CAG99_RS20425	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CAG99_RS20435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAG99_RS20435	COG0574	Belongs to the PEP-utilizing enzyme family
CAG99_RS20470	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CAG99_RS20495	COG0300	oxidoreductase activity
CAG99_RS20510	COG1175	transmembrane transport
CAG99_RS20520	COG1609	Transcriptional regulator
CAG99_RS20560	COG0148	phosphopyruvate hydratase activity
CAG99_RS20570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAG99_RS20590	COG2146	nitrite reductase [NAD(P)H] activity
CAG99_RS20590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAG99_RS20595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAG99_RS20610	COG0671	phosphoesterase, PA-phosphatase related
CAG99_RS20620	COG0243	molybdopterin cofactor binding
CAG99_RS20630	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CAG99_RS20650	COG0358	DNA primase activity
CAG99_RS20655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAG99_RS20660	COG1070	Carbohydrate kinase
CAG99_RS20665	COG0475	glutathione-regulated potassium exporter activity
CAG99_RS20700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAG99_RS20705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAG99_RS20790	COG2304	oxidoreductase activity
CAG99_RS20825	COG1609	Transcriptional regulator
CAG99_RS20830	COG0683	leucine binding
CAG99_RS20855	COG0494	nUDIX hydrolase
CAG99_RS20880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAG99_RS20915	COG1414	Transcriptional regulator
CAG99_RS20925	COG2130	NADP-dependent
CAG99_RS20940	COG0395	ABC-type sugar transport system, permease component
CAG99_RS20965	COG4214	carbohydrate transport
CAG99_RS20990	COG4948	Mandelate Racemase Muconate Lactonizing
CAG99_RS21015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAG99_RS21020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAG99_RS21025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAG99_RS21030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAG99_RS21055	COG0789	Transcriptional regulator
CAG99_RS21100	COG1358	cellular component organization or biogenesis
CAG99_RS21110	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CAG99_RS21190	COG0515	serine threonine protein kinase
CAG99_RS21200	COG1132	(ABC) transporter
CAG99_RS21205	COG1132	(ABC) transporter
CAG99_RS21210	COG2197	response regulator
CAG99_RS21240	COG3845	ABC transporter
CAG99_RS21260	COG1309	transcriptional regulator
CAG99_RS21265	COG0438	transferase activity, transferring glycosyl groups
CAG99_RS21270	COG2226	methyltransferase
CAG99_RS21295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CAG99_RS21310	COG3022	response to hydroperoxide
CAG99_RS21320	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS21325	COG1309	transcriptional regulator
CAG99_RS21350	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CAG99_RS21390	COG1797	cobyrinic acid a,c-diamide synthase activity
CAG99_RS21425	COG1120	ATPase activity
CAG99_RS21430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS21460	COG0018	arginyl-trna synthetase
CAG99_RS21475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAG99_RS21490	COG0745	RESPONSE REGULATOR receiver
CAG99_RS21520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAG99_RS21530	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS21540	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS21545	COG1231	oxidoreductase activity
CAG99_RS21590	COG1295	ribonuclease BN
CAG99_RS21620	COG1215	transferase activity, transferring glycosyl groups
CAG99_RS21635	COG0604	alcohol dehydrogenase
CAG99_RS21645	COG2814	Major facilitator Superfamily
CAG99_RS21675	COG0297	glycogen (starch) synthase activity
CAG99_RS21680	COG3206	protein involved in exopolysaccharide biosynthesis
CAG99_RS21680	COG0489	protein tyrosine kinase activity
CAG99_RS21700	COG1247	-acetyltransferase
CAG99_RS21755	COG0463	Glycosyl transferase, family 2
CAG99_RS21770	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CAG99_RS21775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAG99_RS21780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAG99_RS21785	COG1120	ATPase activity
CAG99_RS21790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS21815	COG0583	DNA-binding transcription factor activity
CAG99_RS21820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CAG99_RS21840	COG0181	hydroxymethylbilane synthase activity
CAG99_RS21890	COG0366	Alpha amylase catalytic
CAG99_RS21895	COG0395	ABC-type sugar transport system, permease component
CAG99_RS21940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CAG99_RS21950	COG0501	Belongs to the peptidase M48B family
CAG99_RS21960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAG99_RS21960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CAG99_RS21965	COG2124	cytochrome p450
CAG99_RS21975	COG0174	glutamine synthetase
CAG99_RS21985	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CAG99_RS22030	COG1175	transmembrane transport
CAG99_RS22035	COG3833	ABC-type maltose transport systems, permease component
CAG99_RS22040	COG0366	Alpha amylase catalytic
CAG99_RS22095	COG2197	response regulator
CAG99_RS22180	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CAG99_RS22185	COG0321	lipoyl(octanoyl) transferase activity
CAG99_RS22200	COG1090	epimerase
CAG99_RS22205	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS22220	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAG99_RS22225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAG99_RS22230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAG99_RS22245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CAG99_RS22255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAG99_RS22275	COG4585	Histidine kinase
CAG99_RS22280	COG2197	response regulator
CAG99_RS22290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CAG99_RS22305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAG99_RS22315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAG99_RS22320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAG99_RS22330	COG1376	ErfK ybiS ycfS ynhG family protein
CAG99_RS22340	COG1845	cytochrome c oxidase, subunit III
CAG99_RS22345	COG2010	Cytochrome c
CAG99_RS22350	COG0723	plastoquinol--plastocyanin reductase activity
CAG99_RS22355	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAG99_RS22360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CAG99_RS22380	COG0791	NLP P60 protein
CAG99_RS22380	COG3883	PFAM NLP P60 protein
CAG99_RS22385	COG0438	transferase activity, transferring glycosyl groups
CAG99_RS22415	COG0003	Pfam Anion-transporting ATPase
CAG99_RS22425	COG1940	carbohydrate kinase activity
CAG99_RS22455	COG2197	response regulator
CAG99_RS22465	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CAG99_RS22475	COG2193	ferroxidase activity
CAG99_RS22480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAG99_RS22490	COG0515	serine threonine protein kinase
CAG99_RS22490	COG2815	serine threonine protein kinase
CAG99_RS22495	COG2022	thiamine diphosphate biosynthetic process
CAG99_RS22500	COG2104	thiamine diphosphate biosynthetic process
CAG99_RS22505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAG99_RS22505	COG2022	thiamine diphosphate biosynthetic process
CAG99_RS22520	COG0352	thiamine-phosphate diphosphorylase activity
CAG99_RS22550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAG99_RS22570	COG0714	Associated with various cellular activities
CAG99_RS22580	COG0275	rRNA processing
CAG99_RS22590	COG0768	penicillin binding
CAG99_RS22595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAG99_RS22605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAG99_RS22610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAG99_RS22620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAG99_RS22625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CAG99_RS22635	COG1496	oxidoreductase activity
CAG99_RS22645	COG1799	cell septum assembly
CAG99_RS22655	COG3599	regulation of cell shape
CAG99_RS22660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAG99_RS22670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CAG99_RS22710	COG0587	DNA-directed DNA polymerase activity
CAG99_RS22740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAG99_RS22750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CAG99_RS22755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAG99_RS22760	COG0131	Imidazoleglycerol-phosphate dehydratase
CAG99_RS22765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CAG99_RS22770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CAG99_RS22775	COG0251	oxidation-reduction process
CAG99_RS22780	COG0107	imidazoleglycerol-phosphate synthase activity
CAG99_RS22785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CAG99_RS22790	COG1053	succinate dehydrogenase
CAG99_RS22810	COG0395	ABC-type sugar transport system, permease component
CAG99_RS22815	COG1175	transmembrane transport
CAG99_RS22845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CAG99_RS22870	COG0134	indole-3-glycerol-phosphate synthase activity
CAG99_RS22885	COG0133	tryptophan synthase activity
CAG99_RS22890	COG0159	tryptophan synthase activity
CAG99_RS22900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAG99_RS22925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAG99_RS22930	COG0067	glutamate synthase
CAG99_RS22930	COG0070	glutamate synthase
CAG99_RS22930	COG0069	glutamate synthase activity
CAG99_RS22945	COG1175	transmembrane transport
CAG99_RS22950	COG0395	ABC-type sugar transport system, permease component
CAG99_RS22960	COG0287	Prephenate dehydrogenase
CAG99_RS22960	COG1605	Chorismate mutase
CAG99_RS23010	COG0683	leucine binding
CAG99_RS23035	COG2050	protein possibly involved in aromatic compounds catabolism
CAG99_RS23065	COG0237	dephospho-CoA kinase activity
CAG99_RS23070	COG0789	Transcriptional regulator
CAG99_RS23125	COG0739	heme binding
CAG99_RS23135	COG0584	glycerophosphoryl diester phosphodiesterase
CAG99_RS23140	COG0556	nucleotide-excision repair
CAG99_RS23150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAG99_RS23165	COG0322	excinuclease ABC activity
CAG99_RS23170	COG1660	Displays ATPase and GTPase activities
CAG99_RS23175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CAG99_RS23180	COG1481	regulation of sporulation
CAG99_RS23185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CAG99_RS23190	COG0126	phosphoglycerate kinase activity
CAG99_RS23195	COG0149	triose-phosphate isomerase activity
CAG99_RS23200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAG99_RS23210	COG0166	Belongs to the GPI family
CAG99_RS23215	COG0363	glucosamine-6-phosphate deaminase activity
CAG99_RS23230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CAG99_RS23240	COG0109	protoheme IX farnesyltransferase activity
CAG99_RS23265	COG1131	(ABC) transporter
CAG99_RS23280	COG0719	Fe-S assembly protein
CAG99_RS23290	COG0396	ATPase activity
CAG99_RS23295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAG99_RS23300	COG0822	iron-sulfur transferase activity
CAG99_RS23305	COG2151	metal-sulfur cluster biosynthetic enzyme
CAG99_RS23315	COG2171	N-acyltransferase activity
CAG99_RS23325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAG99_RS23355	COG1802	Transcriptional regulator
CAG99_RS23360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAG99_RS23370	COG1175	transmembrane transport
CAG99_RS23375	COG0395	ABC-type sugar transport system, permease component
CAG99_RS23395	COG3866	Pectate lyase
CAG99_RS23405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAG99_RS23410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAG99_RS23420	COG2252	PERMEase
CAG99_RS23425	COG1051	belongs to the nudix hydrolase family
CAG99_RS23430	COG0515	serine threonine protein kinase
CAG99_RS23460	COG1366	Belongs to the anti-sigma-factor antagonist family
CAG99_RS23465	COG1366	Belongs to the anti-sigma-factor antagonist family
CAG99_RS23510	COG1917	Cupin 2, conserved barrel domain protein
CAG99_RS23515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAG99_RS23520	COG0456	acetyltransferase
CAG99_RS23535	COG0235	Class ii aldolase
CAG99_RS23550	COG0488	(ABC) transporter
CAG99_RS23560	COG1024	Enoyl-CoA hydratase
CAG99_RS23595	COG2267	carboxylic ester hydrolase activity
CAG99_RS23615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAG99_RS23630	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS23635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAG99_RS23640	COG2186	Transcriptional regulator
CAG99_RS23645	COG2807	transmembrane transport
CAG99_RS23665	COG3830	Belongs to the UPF0237 family
CAG99_RS23665	COG0560	Phosphoserine phosphatase
CAG99_RS23670	COG0842	Transport permease protein
CAG99_RS23670	COG1716	ATPase activity
CAG99_RS23670	COG1131	(ABC) transporter
CAG99_RS23675	COG4585	Histidine kinase
CAG99_RS23680	COG2197	response regulator
CAG99_RS23700	COG1119	ATPase activity
CAG99_RS23720	COG1881	PFAM PEBP family protein
CAG99_RS23730	COG2094	Belongs to the DNA glycosylase MPG family
CAG99_RS23775	COG0647	UMP catabolic process
CAG99_RS23780	COG2375	cellular response to nickel ion
CAG99_RS23795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CAG99_RS23800	COG0497	DNA recombination
CAG99_RS23815	COG3387	PFAM Glycoside hydrolase 15-related
CAG99_RS23820	COG0504	CTP synthase activity
CAG99_RS23825	COG0494	nUDIX hydrolase
CAG99_RS23850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CAG99_RS23855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CAG99_RS23860	COG1187	pseudouridine synthase activity
CAG99_RS23870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CAG99_RS23880	COG1160	GTP binding
CAG99_RS23900	COG0671	phosphoesterase, PA-phosphatase related
CAG99_RS23905	COG1960	acyl-CoA dehydrogenase activity
CAG99_RS23915	COG1799	cell septum assembly
CAG99_RS23930	COG0583	DNA-binding transcription factor activity
CAG99_RS23950	COG0831	urea catabolic process
CAG99_RS23955	COG0832	Belongs to the urease beta subunit family
CAG99_RS23960	COG0804	urea catabolic process
CAG99_RS23965	COG0830	nickel cation binding
CAG99_RS23970	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CAG99_RS23975	COG0829	nickel cation binding
CAG99_RS23990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAG99_RS24000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAG99_RS24020	COG1725	Transcriptional regulator
CAG99_RS24025	COG2362	D-Aminopeptidase
CAG99_RS24030	COG0366	Alpha amylase catalytic
CAG99_RS24035	COG1609	Transcriptional regulator
CAG99_RS24065	COG1595	DNA-templated transcription, initiation
CAG99_RS24070	COG0517	IMP dehydrogenase activity
CAG99_RS24070	COG4175	Glycine betaine
CAG99_RS24075	COG4176	ABC-type proline glycine betaine transport system permease component
CAG99_RS24105	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CAG99_RS24110	COG1518	maintenance of DNA repeat elements
CAG99_RS24140	COG1595	DNA-templated transcription, initiation
CAG99_RS24145	COG0728	peptidoglycan biosynthetic process
CAG99_RS24155	COG0747	negative chemotaxis
CAG99_RS24185	COG1021	2,3-dihydroxybenzoate-AMP ligase
CAG99_RS24210	COG2188	Transcriptional regulator
CAG99_RS24215	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CAG99_RS24250	COG2149	membrane
CAG99_RS24260	COG2814	Major facilitator Superfamily
CAG99_RS24265	COG4336	lyase activity
CAG99_RS24270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CAG99_RS24275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CAG99_RS24280	COG1984	allophanate hydrolase subunit 2
CAG99_RS24345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAG99_RS24375	COG0411	ABC transporter
CAG99_RS24385	COG1522	sequence-specific DNA binding
CAG99_RS24415	COG0655	NAD(P)H dehydrogenase (quinone) activity
CAG99_RS24420	COG0488	(ABC) transporter
CAG99_RS24435	COG1131	(ABC) transporter
CAG99_RS24445	COG0438	transferase activity, transferring glycosyl groups
CAG99_RS24500	COG3845	ABC transporter
CAG99_RS24535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAG99_RS24545	COG1522	sequence-specific DNA binding
CAG99_RS24550	COG1834	amidinotransferase
CAG99_RS24555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAG99_RS24615	COG2267	carboxylic ester hydrolase activity
CAG99_RS24620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAG99_RS24625	COG1051	belongs to the nudix hydrolase family
CAG99_RS24630	COG1024	Enoyl-CoA hydratase
CAG99_RS24645	COG3467	pyridoxamine 5'-phosphate
CAG99_RS24705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAG99_RS24720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAG99_RS24750	COG0667	Aldo Keto reductase
CAG99_RS24755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAG99_RS24775	COG0215	cysteine-tRNA ligase activity
CAG99_RS24785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CAG99_RS24790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CAG99_RS24795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAG99_RS24800	COG1414	Transcriptional regulator
CAG99_RS24805	COG1410	methionine synthase
CAG99_RS24805	COG0646	methionine synthase
CAG99_RS24815	COG2197	response regulator
CAG99_RS24825	COG1994	Peptidase M50
CAG99_RS24825	COG0517	IMP dehydrogenase activity
CAG99_RS24845	COG1222	aaa ATPase
CAG99_RS24850	COG4122	O-methyltransferase activity
CAG99_RS24860	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CAG99_RS24865	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CAG99_RS24870	COG1609	Transcriptional regulator
CAG99_RS24880	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CAG99_RS24910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAG99_RS24915	COG0805	protein transport
CAG99_RS24930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAG99_RS24935	COG0475	glutathione-regulated potassium exporter activity
CAG99_RS24945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CAG99_RS24975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAG99_RS24985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CAG99_RS24990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CAG99_RS24995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CAG99_RS25000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAG99_RS25005	COG5002	protein histidine kinase activity
CAG99_RS25010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAG99_RS25015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAG99_RS25015	COG0072	phenylalanine-tRNA ligase activity
CAG99_RS25025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CAG99_RS25040	COG1649	PFAM Uncharacterised BCR, COG1649
CAG99_RS25050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAG99_RS25070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CAG99_RS25075	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CAG99_RS25080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAG99_RS25085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAG99_RS25090	COG1438	arginine binding
CAG99_RS25110	COG0137	argininosuccinate synthase activity
CAG99_RS25115	COG0165	Argininosuccinate lyase
CAG99_RS25130	COG0604	alcohol dehydrogenase
CAG99_RS25145	COG0318	PFAM AMP-dependent synthetase and ligase
CAG99_RS25145	COG0204	Acyl-transferase
CAG99_RS25150	COG0584	glycerophosphoryl diester phosphodiesterase
CAG99_RS25170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAG99_RS25175	COG2011	ABC-type metal ion transport system permease component
CAG99_RS25180	COG1464	Belongs to the NlpA lipoprotein family
CAG99_RS25195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CAG99_RS25200	COG1648	precorrin-2 dehydrogenase activity
CAG99_RS25200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAG99_RS25210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAG99_RS25210	COG0515	serine threonine protein kinase
CAG99_RS25280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAG99_RS25295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAG99_RS25300	COG1560	Kdo2-lipid A biosynthetic process
CAG99_RS25305	COG0438	transferase activity, transferring glycosyl groups
CAG99_RS25315	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CAG99_RS25320	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CAG99_RS25325	COG0217	transcriptional regulatory protein
CAG99_RS25330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CAG99_RS25335	COG0632	four-way junction helicase activity
CAG99_RS25340	COG2255	four-way junction helicase activity
CAG99_RS25355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAG99_RS25360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAG99_RS25365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CAG99_RS25370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAG99_RS25375	COG1196	nuclear chromosome segregation
CAG99_RS25380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAG99_RS25390	COG0124	histidyl-tRNA synthetase
CAG99_RS25410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CAG99_RS25430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAG99_RS25435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CAG99_RS25440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAG99_RS25445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAG99_RS25450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CAG99_RS25455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAG99_RS25460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CAG99_RS25465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAG99_RS25475	COG0006	proline dipeptidase activity
CAG99_RS25480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAG99_RS25485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAG99_RS25495	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CAG99_RS25500	COG0540	Belongs to the ATCase OTCase family
CAG99_RS25505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAG99_RS25515	COG0505	Belongs to the CarA family
CAG99_RS25520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAG99_RS25525	COG0167	dihydroorotate dehydrogenase activity
CAG99_RS25530	COG0284	orotidine-5'-phosphate decarboxylase activity
CAG99_RS25545	COG1758	RNA polymerase activity
CAG99_RS25555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAG99_RS25570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAG99_RS25580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CAG99_RS25585	COG2390	Transcriptional regulator
CAG99_RS25610	COG2223	nitrite transmembrane transporter activity
CAG99_RS25615	COG1846	Transcriptional regulator
CAG99_RS25615	COG1940	carbohydrate kinase activity
CAG99_RS25630	COG3201	nicotinamide mononucleotide transporter
CAG99_RS25635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAG99_RS25635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAG99_RS25640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CAG99_RS25645	COG0140	phosphoribosyl-ATP diphosphatase activity
CAG99_RS25650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CAG99_RS25680	COG1960	acyl-CoA dehydrogenase activity
CAG99_RS25690	COG1522	sequence-specific DNA binding
CAG99_RS25705	COG1216	Glycosyl transferase, family 2
CAG99_RS25720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAG99_RS25725	COG1349	DNA-binding transcription factor activity
CAG99_RS25740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAG99_RS25745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAG99_RS25760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CAG99_RS25775	COG1461	Dihydroxyacetone kinase
CAG99_RS25780	COG2376	Dihydroxyacetone kinase
CAG99_RS25795	COG1609	Transcriptional regulator
CAG99_RS25810	COG1175	transmembrane transport
CAG99_RS25815	COG0395	ABC-type sugar transport system, permease component
CAG99_RS25820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CAG99_RS25830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAG99_RS25845	COG2226	methyltransferase
CAG99_RS25850	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAG99_RS25865	COG2706	6-phosphogluconolactonase activity
CAG99_RS25890	COG4948	Mandelate Racemase Muconate Lactonizing
CAG99_RS25895	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS25900	COG0800	Aldolase
CAG99_RS25905	COG1414	Transcriptional regulator
CAG99_RS25915	COG0515	serine threonine protein kinase
CAG99_RS25980	COG2018	Roadblock/LC7 domain
CAG99_RS25985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAG99_RS25995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAG99_RS26005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAG99_RS26040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAG99_RS26050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAG99_RS26050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAG99_RS26115	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS26120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CAG99_RS26135	COG1968	undecaprenyl-diphosphatase activity
CAG99_RS26175	COG0640	Transcriptional regulator
CAG99_RS26185	COG2391	methyltransferase activity
CAG99_RS26200	COG0596	Alpha beta hydrolase
CAG99_RS26205	COG3629	intracellular signal transduction
CAG99_RS26205	COG3903	Transcriptional regulator
CAG99_RS26225	COG0604	alcohol dehydrogenase
CAG99_RS26225	COG3321	synthase
CAG99_RS26250	COG0367	asparagine synthase
CAG99_RS26255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAG99_RS26265	COG2226	methyltransferase
CAG99_RS26290	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS26300	COG4106	trans-aconitate 2-methyltransferase activity
CAG99_RS26305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS26310	COG1120	ATPase activity
CAG99_RS26315	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS26330	COG1832	CoA-binding protein
CAG99_RS26335	COG1739	Uncharacterized protein family UPF0029
CAG99_RS26340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAG99_RS26350	COG0420	3'-5' exonuclease activity
CAG99_RS26355	COG0419	ATPase involved in DNA repair
CAG99_RS26360	COG0515	serine threonine protein kinase
CAG99_RS26360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAG99_RS26365	COG0515	serine threonine protein kinase
CAG99_RS26365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAG99_RS26385	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS26390	COG2188	Transcriptional regulator
CAG99_RS26395	COG1940	carbohydrate kinase activity
CAG99_RS26400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CAG99_RS26410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAG99_RS26455	COG1132	(ABC) transporter
CAG99_RS26485	COG0697	spore germination
CAG99_RS26495	COG1556	Lactate utilization protein
CAG99_RS26500	COG1139	Iron-sulfur cluster binding protein
CAG99_RS26505	COG0247	lactate metabolic process
CAG99_RS26510	COG1070	Carbohydrate kinase
CAG99_RS26515	COG3347	Dehydrogenase
CAG99_RS26515	COG1028	Short-chain dehydrogenase reductase Sdr
CAG99_RS26525	COG3254	rhamnose metabolic process
CAG99_RS26535	COG0432	Pfam Uncharacterised protein family UPF0047
CAG99_RS26605	COG4555	ABC transporter
CAG99_RS26640	COG3401	FG-GAP repeat protein
CAG99_RS26660	COG3401	FG-GAP repeat protein
CAG99_RS26675	COG1132	(ABC) transporter
CAG99_RS26685	COG1609	Transcriptional regulator
CAG99_RS26740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CAG99_RS26745	COG4106	trans-aconitate 2-methyltransferase activity
CAG99_RS26750	COG2345	Transcriptional regulator
CAG99_RS26760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAG99_RS26765	COG2197	response regulator
CAG99_RS26770	COG4585	Histidine kinase
CAG99_RS26780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAG99_RS26785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAG99_RS26790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAG99_RS26795	COG1215	transferase activity, transferring glycosyl groups
CAG99_RS26805	COG0667	Aldo Keto reductase
CAG99_RS26810	COG1215	transferase activity, transferring glycosyl groups
CAG99_RS26815	COG0726	polysaccharide deacetylase
CAG99_RS26825	COG1064	alcohol dehydrogenase
CAG99_RS26840	COG1657	PFAM Prenyltransferase squalene oxidase
CAG99_RS26860	COG1349	DNA-binding transcription factor activity
CAG99_RS26865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAG99_RS26870	COG3684	Belongs to the aldolase LacD family
CAG99_RS26880	COG2271	Major facilitator Superfamily
CAG99_RS26890	COG0477	Major facilitator Superfamily
CAG99_RS26900	COG1120	ATPase activity
CAG99_RS26905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAG99_RS26910	COG2226	methyltransferase
CAG99_RS26920	COG3537	Alpha-1,2-mannosidase
CAG99_RS26960	COG0477	Major facilitator Superfamily
CAG99_RS26970	COG1122	ATPase activity
CAG99_RS26975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAG99_RS26995	COG3629	intracellular signal transduction
CAG99_RS26995	COG3903	Transcriptional regulator
CAG99_RS27030	COG1609	Transcriptional regulator
CAG99_RS27045	COG0640	Transcriptional regulator
CAG99_RS27095	COG2124	cytochrome p450
CAG99_RS27125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CAG99_RS27170	COG1426	Protein conserved in bacteria
CAG99_RS27225	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CAG99_RS27245	COG1660	Displays ATPase and GTPase activities
CAG99_RS27270	COG3903	Transcriptional regulator
CAG99_RS27270	COG3629	intracellular signal transduction
CAG99_RS27275	COG2409	Drug exporters of the RND superfamily
CAG99_RS27290	COG2223	nitrite transmembrane transporter activity
CAG99_RS27315	COG3442	glutamine amidotransferase
CAG99_RS27345	COG1228	amidohydrolase
CAG99_RS27350	COG2267	carboxylic ester hydrolase activity
CAG99_RS27355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity