locus-tag	class	description
B9S66_RS00070	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9S66_RS00075	COG3246	L-lysine catabolic process to acetate
B9S66_RS00105	COG0477	Major facilitator Superfamily
B9S66_RS00130	COG4335	DNA alkylation repair
B9S66_RS00140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B9S66_RS00140	COG0300	oxidoreductase activity
B9S66_RS00140	COG3321	synthase
B9S66_RS00140	COG4221	oxidoreductase activity
B9S66_RS00160	COG0583	DNA-binding transcription factor activity
B9S66_RS00185	COG1404	Belongs to the peptidase S8 family
B9S66_RS00265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B9S66_RS00275	COG0604	alcohol dehydrogenase
B9S66_RS00290	COG3396	Phenylacetate-CoA oxygenase
B9S66_RS00300	COG3396	Phenylacetate-CoA oxygenase
B9S66_RS00305	COG2151	metal-sulfur cluster biosynthetic enzyme
B9S66_RS00310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B9S66_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS00320	COG3483	tryptophan 2,3-dioxygenase activity
B9S66_RS00350	COG1129	ABC transporter
B9S66_RS00360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9S66_RS00400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B9S66_RS00405	COG2124	cytochrome p450
B9S66_RS00425	COG3321	synthase
B9S66_RS00425	COG0604	alcohol dehydrogenase
B9S66_RS00440	COG3321	synthase
B9S66_RS00440	COG0604	alcohol dehydrogenase
B9S66_RS00455	COG0604	alcohol dehydrogenase
B9S66_RS00455	COG3321	synthase
B9S66_RS00495	COG0142	geranyltranstransferase activity
B9S66_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS00555	COG2271	Major facilitator Superfamily
B9S66_RS00565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B9S66_RS00570	COG0277	FAD linked oxidase domain protein
B9S66_RS00595	COG2318	DinB family
B9S66_RS00600	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
B9S66_RS00610	COG1124	(ABC) transporter
B9S66_RS00615	COG0444	Belongs to the ABC transporter superfamily
B9S66_RS00620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS00625	COG0601	transmembrane transport
B9S66_RS00635	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS00640	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS00665	COG0517	IMP dehydrogenase activity
B9S66_RS00665	COG1125	glycine betaine transport
B9S66_RS00675	COG1174	glycine betaine transport
B9S66_RS00680	COG1174	glycine betaine transport
B9S66_RS00685	COG2124	cytochrome p450
B9S66_RS00700	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS00710	COG0583	DNA-binding transcription factor activity
B9S66_RS00715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B9S66_RS00725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9S66_RS00735	COG1116	anion transmembrane transporter activity
B9S66_RS00755	COG0431	NADPH-dependent FMN reductase
B9S66_RS00765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9S66_RS00770	COG4608	Belongs to the ABC transporter superfamily
B9S66_RS00780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS00815	COG0235	Class ii aldolase
B9S66_RS00820	COG3395	kinase activity
B9S66_RS00835	COG1349	DNA-binding transcription factor activity
B9S66_RS00855	COG0242	peptide deformylase activity
B9S66_RS00870	COG0110	maltose O-acetyltransferase activity
B9S66_RS00880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B9S66_RS00885	COG1132	(ABC) transporter
B9S66_RS00890	COG1132	(ABC) transporter
B9S66_RS00915	COG1120	ATPase activity
B9S66_RS00925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS00955	COG1984	allophanate hydrolase subunit 2
B9S66_RS00960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B9S66_RS00965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B9S66_RS00985	COG2146	nitrite reductase [NAD(P)H] activity
B9S66_RS00985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9S66_RS00990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9S66_RS00995	COG0243	molybdopterin cofactor binding
B9S66_RS01000	COG0745	RESPONSE REGULATOR receiver
B9S66_RS01035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B9S66_RS01045	COG0300	oxidoreductase activity
B9S66_RS01050	COG2201	protein-glutamate methylesterase activity
B9S66_RS01080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B9S66_RS01085	COG0590	tRNA wobble adenosine to inosine editing
B9S66_RS01090	COG0363	glucosamine-6-phosphate deaminase activity
B9S66_RS01095	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
B9S66_RS01105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B9S66_RS01115	COG3458	cephalosporin-C deacetylase activity
B9S66_RS01125	COG0747	negative chemotaxis
B9S66_RS01130	COG0601	transmembrane transport
B9S66_RS01135	COG0444	Belongs to the ABC transporter superfamily
B9S66_RS01140	COG4608	Belongs to the ABC transporter superfamily
B9S66_RS01145	COG1121	(ABC) transporter
B9S66_RS01150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B9S66_RS01160	COG0803	Belongs to the bacterial solute-binding protein 9 family
B9S66_RS01170	COG4257	antibiotic catabolic process
B9S66_RS01180	COG3655	Transcriptional regulator
B9S66_RS01200	COG0464	growth
B9S66_RS01270	COG4948	Mandelate Racemase Muconate Lactonizing
B9S66_RS01275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B9S66_RS01290	COG3119	arylsulfatase activity
B9S66_RS01320	COG0477	Major facilitator Superfamily
B9S66_RS01350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B9S66_RS01355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B9S66_RS01360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B9S66_RS01365	COG0254	rRNA binding
B9S66_RS01375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B9S66_RS01400	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B9S66_RS01430	COG0142	geranyltranstransferase activity
B9S66_RS01435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B9S66_RS01435	COG1796	DNA polymerase
B9S66_RS01445	COG2837	iron assimilation
B9S66_RS01465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B9S66_RS01470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B9S66_RS01490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B9S66_RS01495	COG0121	glutamine amidotransferase
B9S66_RS01500	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B9S66_RS01505	COG2182	Extracellular solute-binding protein
B9S66_RS01510	COG3360	Dodecin
B9S66_RS01520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9S66_RS01525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B9S66_RS01530	COG1053	succinate dehydrogenase
B9S66_RS01540	COG0583	DNA-binding transcription factor activity
B9S66_RS01605	COG3275	phosphorelay sensor kinase activity
B9S66_RS01610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9S66_RS01620	COG3279	Response regulator of the LytR AlgR family
B9S66_RS01625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B9S66_RS01655	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B9S66_RS01660	COG3693	PFAM glycoside hydrolase, family 10
B9S66_RS01685	COG1132	(ABC) transporter
B9S66_RS01695	COG1595	DNA-templated transcription, initiation
B9S66_RS01705	COG0656	L-ascorbic acid biosynthetic process
B9S66_RS01725	COG0784	Response regulator, receiver
B9S66_RS01730	COG4251	negative regulation of phosphorylation
B9S66_RS01775	COG0501	Belongs to the peptidase M48B family
B9S66_RS01780	COG2723	6-phospho-beta-galactosidase activity
B9S66_RS01785	COG0395	ABC-type sugar transport system, permease component
B9S66_RS01790	COG1175	transmembrane transport
B9S66_RS01815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B9S66_RS01835	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS01845	COG0242	peptide deformylase activity
B9S66_RS01855	COG3442	glutamine amidotransferase
B9S66_RS01860	COG0205	6-phosphofructokinase activity
B9S66_RS01870	COG2770	Histidine kinase
B9S66_RS01870	COG2208	phosphoserine phosphatase activity
B9S66_RS01885	COG0435	Glutathione S-transferase
B9S66_RS01895	COG2175	clavaminate synthase activity
B9S66_RS01940	COG0204	Acyl-transferase
B9S66_RS01945	COG4552	Acetyltransferase involved in intracellular survival and related
B9S66_RS01950	COG0829	nickel cation binding
B9S66_RS01955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B9S66_RS01965	COG0804	urea catabolic process
B9S66_RS01970	COG0832	Belongs to the urease beta subunit family
B9S66_RS01975	COG0831	urea catabolic process
B9S66_RS01990	COG0791	NLP P60 protein
B9S66_RS02015	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B9S66_RS02020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B9S66_RS02025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B9S66_RS02035	COG0488	(ABC) transporter
B9S66_RS02040	COG0488	(ABC) transporter
B9S66_RS02045	COG0456	acetyltransferase
B9S66_RS02065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B9S66_RS02070	COG3663	DNA glycosylase
B9S66_RS02085	COG1940	carbohydrate kinase activity
B9S66_RS02090	COG2188	Transcriptional regulator
B9S66_RS02115	COG0626	cystathionine gamma-synthase activity
B9S66_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS02140	COG1522	sequence-specific DNA binding
B9S66_RS02145	COG0419	ATPase involved in DNA repair
B9S66_RS02150	COG0420	3'-5' exonuclease activity
B9S66_RS02165	COG1595	DNA-templated transcription, initiation
B9S66_RS02185	COG1739	Uncharacterized protein family UPF0029
B9S66_RS02190	COG1832	CoA-binding protein
B9S66_RS02200	COG0110	maltose O-acetyltransferase activity
B9S66_RS02260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B9S66_RS02280	COG1968	undecaprenyl-diphosphatase activity
B9S66_RS02290	COG1982	Orn Lys Arg decarboxylase major
B9S66_RS02300	COG2826	transposase and inactivated derivatives, IS30 family
B9S66_RS02315	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B9S66_RS02345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B9S66_RS02385	COG0154	amidase activity
B9S66_RS02395	COG4251	negative regulation of phosphorylation
B9S66_RS02415	COG0697	spore germination
B9S66_RS02430	COG0697	spore germination
B9S66_RS02450	COG0539	negative regulation of cytoplasmic translation
B9S66_RS02490	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B9S66_RS02490	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B9S66_RS02500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B9S66_RS02520	COG1716	ATPase activity
B9S66_RS02540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B9S66_RS02575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B9S66_RS02585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B9S66_RS02605	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B9S66_RS02695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B9S66_RS02700	COG2364	Membrane
B9S66_RS02710	COG2270	Major facilitator Superfamily
B9S66_RS02720	COG3030	protein affecting phage T7 exclusion by the F plasmid
B9S66_RS02725	COG0463	Glycosyl transferase, family 2
B9S66_RS02750	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS02780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B9S66_RS02785	COG0140	phosphoribosyl-ATP diphosphatase activity
B9S66_RS02790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B9S66_RS02795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B9S66_RS02795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B9S66_RS02800	COG3201	nicotinamide mononucleotide transporter
B9S66_RS02815	COG1090	epimerase
B9S66_RS02820	COG1940	carbohydrate kinase activity
B9S66_RS02820	COG1846	Transcriptional regulator
B9S66_RS02825	COG0738	Major facilitator superfamily
B9S66_RS02835	COG2233	PERMEase
B9S66_RS02840	COG0697	spore germination
B9S66_RS02860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9S66_RS02900	COG2390	Transcriptional regulator
B9S66_RS02905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B9S66_RS02910	COG2318	DinB family
B9S66_RS02925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B9S66_RS02945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B9S66_RS02955	COG1758	RNA polymerase activity
B9S66_RS02970	COG0284	orotidine-5'-phosphate decarboxylase activity
B9S66_RS02975	COG0167	dihydroorotate dehydrogenase activity
B9S66_RS02980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B9S66_RS02985	COG0505	Belongs to the CarA family
B9S66_RS02995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B9S66_RS03000	COG0540	Belongs to the ATCase OTCase family
B9S66_RS03005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B9S66_RS03015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B9S66_RS03020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B9S66_RS03025	COG0006	proline dipeptidase activity
B9S66_RS03035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B9S66_RS03040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B9S66_RS03045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B9S66_RS03050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B9S66_RS03055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B9S66_RS03060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B9S66_RS03065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B9S66_RS03080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B9S66_RS03095	COG0124	histidyl-tRNA synthetase
B9S66_RS03105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B9S66_RS03110	COG1196	nuclear chromosome segregation
B9S66_RS03120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B9S66_RS03125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B9S66_RS03130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B9S66_RS03135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B9S66_RS03145	COG2255	four-way junction helicase activity
B9S66_RS03150	COG0632	four-way junction helicase activity
B9S66_RS03155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B9S66_RS03160	COG0217	transcriptional regulatory protein
B9S66_RS03165	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B9S66_RS03170	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B9S66_RS03180	COG0438	transferase activity, transferring glycosyl groups
B9S66_RS03185	COG1560	Kdo2-lipid A biosynthetic process
B9S66_RS03190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B9S66_RS03205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B9S66_RS03210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B9S66_RS03265	COG0456	acetyltransferase
B9S66_RS03340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B9S66_RS03340	COG1648	precorrin-2 dehydrogenase activity
B9S66_RS03345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B9S66_RS03360	COG1464	Belongs to the NlpA lipoprotein family
B9S66_RS03365	COG1464	Belongs to the NlpA lipoprotein family
B9S66_RS03370	COG2011	ABC-type metal ion transport system permease component
B9S66_RS03375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B9S66_RS03380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B9S66_RS03405	COG0584	glycerophosphoryl diester phosphodiesterase
B9S66_RS03410	COG0318	PFAM AMP-dependent synthetase and ligase
B9S66_RS03410	COG0204	Acyl-transferase
B9S66_RS03415	COG0477	Major facilitator Superfamily
B9S66_RS03435	COG0165	Argininosuccinate lyase
B9S66_RS03445	COG0385	Bile acid
B9S66_RS03450	COG2409	Drug exporters of the RND superfamily
B9S66_RS03460	COG2197	response regulator
B9S66_RS03465	COG4585	Histidine kinase
B9S66_RS03470	COG1438	arginine binding
B9S66_RS03475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B9S66_RS03480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B9S66_RS03485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B9S66_RS03490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B9S66_RS03525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B9S66_RS03540	COG1309	transcriptional regulator
B9S66_RS03555	COG2838	Isocitrate dehydrogenase
B9S66_RS03595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B9S66_RS03600	COG0697	spore germination
B9S66_RS03630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9S66_RS03630	COG0072	phenylalanine-tRNA ligase activity
B9S66_RS03635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B9S66_RS03640	COG5002	protein histidine kinase activity
B9S66_RS03650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B9S66_RS03655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B9S66_RS03660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B9S66_RS03665	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B9S66_RS03675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B9S66_RS03710	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS03715	COG0174	glutamine synthetase
B9S66_RS03725	COG0531	amino acid
B9S66_RS03730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B9S66_RS03755	COG4175	Glycine betaine
B9S66_RS03755	COG0517	IMP dehydrogenase activity
B9S66_RS03760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B9S66_RS03770	COG1595	DNA-templated transcription, initiation
B9S66_RS03780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B9S66_RS03790	COG0564	pseudouridine synthase activity
B9S66_RS03820	COG2124	cytochrome p450
B9S66_RS03835	COG0805	protein transport
B9S66_RS03840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B9S66_RS03875	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B9S66_RS03890	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B9S66_RS03895	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B9S66_RS03905	COG4122	O-methyltransferase activity
B9S66_RS03910	COG1222	aaa ATPase
B9S66_RS03930	COG1994	Peptidase M50
B9S66_RS03930	COG0517	IMP dehydrogenase activity
B9S66_RS03940	COG2197	response regulator
B9S66_RS03945	COG0747	negative chemotaxis
B9S66_RS03955	COG1410	methionine synthase
B9S66_RS03955	COG0646	methionine synthase
B9S66_RS03965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B9S66_RS03970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B9S66_RS03975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B9S66_RS03990	COG0215	cysteine-tRNA ligase activity
B9S66_RS04010	COG0598	Magnesium transport protein CorA
B9S66_RS04020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9S66_RS04025	COG0667	Aldo Keto reductase
B9S66_RS04060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B9S66_RS04070	COG3189	MarR family transcriptional regulator
B9S66_RS04075	COG3012	SEC-C Motif Domain Protein
B9S66_RS04085	COG3265	gluconokinase activity
B9S66_RS04125	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B9S66_RS04130	COG2149	membrane
B9S66_RS04150	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS04160	COG0318	PFAM AMP-dependent synthetase and ligase
B9S66_RS04175	COG0488	(ABC) transporter
B9S66_RS04185	COG3876	Protein conserved in bacteria
B9S66_RS04235	COG1309	transcriptional regulator
B9S66_RS04260	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B9S66_RS04265	COG2188	Transcriptional regulator
B9S66_RS04270	COG3973	AAA domain
B9S66_RS04290	COG2755	lipolytic protein G-D-S-L family
B9S66_RS04310	COG1216	Glycosyl transferase, family 2
B9S66_RS04375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B9S66_RS04380	COG0587	DNA-directed DNA polymerase activity
B9S66_RS04395	COG0330	HflC and HflK could
B9S66_RS04415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9S66_RS04430	COG0765	amino acid transport
B9S66_RS04440	COG0765	amino acid transport
B9S66_RS04455	COG1799	cell septum assembly
B9S66_RS04460	COG0477	Major facilitator Superfamily
B9S66_RS04470	COG0671	phosphoesterase, PA-phosphatase related
B9S66_RS04490	COG0438	transferase activity, transferring glycosyl groups
B9S66_RS04510	COG1160	GTP binding
B9S66_RS04520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B9S66_RS04535	COG3541	Predicted nucleotidyltransferase
B9S66_RS04540	COG1397	ADP-ribosylglycohydrolase
B9S66_RS04550	COG1187	pseudouridine synthase activity
B9S66_RS04555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B9S66_RS04560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B9S66_RS04575	COG0686	Belongs to the AlaDH PNT family
B9S66_RS04585	COG0494	nUDIX hydrolase
B9S66_RS04590	COG0504	CTP synthase activity
B9S66_RS04595	COG3387	PFAM Glycoside hydrolase 15-related
B9S66_RS04610	COG0297	glycogen (starch) synthase activity
B9S66_RS04625	COG0497	DNA recombination
B9S66_RS04630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B9S66_RS04650	COG0647	UMP catabolic process
B9S66_RS04690	COG2094	Belongs to the DNA glycosylase MPG family
B9S66_RS04700	COG1881	PFAM PEBP family protein
B9S66_RS04720	COG1119	ATPase activity
B9S66_RS04735	COG2197	response regulator
B9S66_RS04760	COG1716	ATPase activity
B9S66_RS04760	COG1131	(ABC) transporter
B9S66_RS04760	COG0842	Transport permease protein
B9S66_RS04765	COG3830	Belongs to the UPF0237 family
B9S66_RS04765	COG0560	Phosphoserine phosphatase
B9S66_RS04780	COG2807	transmembrane transport
B9S66_RS04785	COG2186	Transcriptional regulator
B9S66_RS04795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B9S66_RS04805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B9S66_RS04810	COG2261	transglycosylase associated protein
B9S66_RS04830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B9S66_RS04840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B9S66_RS04845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9S66_RS04860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B9S66_RS04880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B9S66_RS04935	COG0488	(ABC) transporter
B9S66_RS04955	COG0235	Class ii aldolase
B9S66_RS04970	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B9S66_RS04975	COG1492	cobalamin metabolic process
B9S66_RS04990	COG1797	cobyrinic acid a,c-diamide synthase activity
B9S66_RS05020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B9S66_RS05025	COG0456	acetyltransferase
B9S66_RS05035	COG1917	Cupin 2, conserved barrel domain protein
B9S66_RS05040	COG5285	phytanoyl-CoA dioxygenase
B9S66_RS05045	COG1902	pentaerythritol trinitrate reductase activity
B9S66_RS05075	COG4585	Histidine kinase
B9S66_RS05080	COG2197	response regulator
B9S66_RS05110	COG2171	N-acyltransferase activity
B9S66_RS05120	COG0822	iron-sulfur transferase activity
B9S66_RS05125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B9S66_RS05130	COG0396	ATPase activity
B9S66_RS05140	COG0719	Fe-S assembly protein
B9S66_RS05155	COG1131	(ABC) transporter
B9S66_RS05165	COG1612	heme a metabolic process
B9S66_RS05180	COG0109	protoheme IX farnesyltransferase activity
B9S66_RS05185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B9S66_RS05190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B9S66_RS05205	COG0363	glucosamine-6-phosphate deaminase activity
B9S66_RS05210	COG0166	Belongs to the GPI family
B9S66_RS05220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B9S66_RS05225	COG0149	triose-phosphate isomerase activity
B9S66_RS05230	COG0126	phosphoglycerate kinase activity
B9S66_RS05235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B9S66_RS05240	COG1481	regulation of sporulation
B9S66_RS05250	COG1660	Displays ATPase and GTPase activities
B9S66_RS05255	COG0322	excinuclease ABC activity
B9S66_RS05270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B9S66_RS05280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B9S66_RS05285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B9S66_RS05305	COG0556	nucleotide-excision repair
B9S66_RS05315	COG0584	glycerophosphoryl diester phosphodiesterase
B9S66_RS05325	COG0477	Major facilitator Superfamily
B9S66_RS05375	COG1288	antiporter activity
B9S66_RS05400	COG0237	dephospho-CoA kinase activity
B9S66_RS05420	COG2226	methyltransferase
B9S66_RS05425	COG1643	Atp-dependent helicase
B9S66_RS05445	COG2050	protein possibly involved in aromatic compounds catabolism
B9S66_RS05450	COG2746	aminoglycoside 3-N-acetyltransferase activity
B9S66_RS05460	COG0559	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS05500	COG0737	Belongs to the 5'-nucleotidase family
B9S66_RS05505	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B9S66_RS05535	COG0287	Prephenate dehydrogenase
B9S66_RS05535	COG1605	Chorismate mutase
B9S66_RS05545	COG0513	Belongs to the DEAD box helicase family
B9S66_RS05550	COG1278	Cold shock
B9S66_RS05565	COG0070	glutamate synthase
B9S66_RS05565	COG0069	glutamate synthase activity
B9S66_RS05565	COG0067	glutamate synthase
B9S66_RS05595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9S66_RS05600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B9S66_RS05610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B9S66_RS05620	COG0159	tryptophan synthase activity
B9S66_RS05625	COG0133	tryptophan synthase activity
B9S66_RS05630	COG0134	indole-3-glycerol-phosphate synthase activity
B9S66_RS05660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B9S66_RS05670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B9S66_RS05675	COG0107	imidazoleglycerol-phosphate synthase activity
B9S66_RS05680	COG0251	oxidation-reduction process
B9S66_RS05685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B9S66_RS05690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B9S66_RS05695	COG0131	Imidazoleglycerol-phosphate dehydratase
B9S66_RS05700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B9S66_RS05705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B9S66_RS05725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B9S66_RS05745	COG1432	Conserved Protein
B9S66_RS05750	COG0587	DNA-directed DNA polymerase activity
B9S66_RS05770	COG0515	serine threonine protein kinase
B9S66_RS05785	COG2153	protein acetylation
B9S66_RS05795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B9S66_RS05805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B9S66_RS05815	COG3599	regulation of cell shape
B9S66_RS05825	COG1799	cell septum assembly
B9S66_RS05835	COG1496	oxidoreductase activity
B9S66_RS05840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B9S66_RS05845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B9S66_RS05850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B9S66_RS05860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B9S66_RS05865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B9S66_RS05875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B9S66_RS05890	COG0275	rRNA processing
B9S66_RS05900	COG0714	Associated with various cellular activities
B9S66_RS05920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B9S66_RS05925	COG1121	(ABC) transporter
B9S66_RS05935	COG1309	transcriptional regulator
B9S66_RS05955	COG0352	thiamine-phosphate diphosphorylase activity
B9S66_RS05965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9S66_RS05970	COG2022	thiamine diphosphate biosynthetic process
B9S66_RS05970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9S66_RS05980	COG2022	thiamine diphosphate biosynthetic process
B9S66_RS05985	COG2815	serine threonine protein kinase
B9S66_RS05985	COG0515	serine threonine protein kinase
B9S66_RS05990	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B9S66_RS05995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B9S66_RS06000	COG2193	ferroxidase activity
B9S66_RS06005	COG0243	molybdopterin cofactor binding
B9S66_RS06010	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B9S66_RS06025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B9S66_RS06030	COG2197	response regulator
B9S66_RS06035	COG4585	Histidine kinase
B9S66_RS06060	COG1940	carbohydrate kinase activity
B9S66_RS06070	COG0003	Pfam Anion-transporting ATPase
B9S66_RS06090	COG0438	transferase activity, transferring glycosyl groups
B9S66_RS06125	COG0705	Rhomboid family
B9S66_RS06140	COG5002	protein histidine kinase activity
B9S66_RS06145	COG0745	RESPONSE REGULATOR receiver
B9S66_RS06155	COG1929	Belongs to the glycerate kinase type-1 family
B9S66_RS06160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B9S66_RS06165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B9S66_RS06170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B9S66_RS06175	COG0723	plastoquinol--plastocyanin reductase activity
B9S66_RS06180	COG2010	Cytochrome c
B9S66_RS06185	COG1845	cytochrome c oxidase, subunit III
B9S66_RS06195	COG1376	ErfK ybiS ycfS ynhG family protein
B9S66_RS06205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B9S66_RS06210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B9S66_RS06215	COG1104	cysteine desulfurase activity
B9S66_RS06220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9S66_RS06245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B9S66_RS06250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B9S66_RS06255	COG2197	response regulator
B9S66_RS06300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B9S66_RS06310	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B9S66_RS06315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B9S66_RS06320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B9S66_RS06325	COG0508	dehydrogenase complex catalyzes the overall conversion of
B9S66_RS06335	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B9S66_RS06350	COG4221	oxidoreductase activity
B9S66_RS06375	COG0456	acetyltransferase
B9S66_RS06385	COG0321	lipoyl(octanoyl) transferase activity
B9S66_RS06390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B9S66_RS06435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B9S66_RS06445	COG2376	Dihydroxyacetone kinase
B9S66_RS06455	COG2326	polyphosphate kinase activity
B9S66_RS06460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B9S66_RS06520	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS06550	COG0745	RESPONSE REGULATOR receiver
B9S66_RS06575	COG1309	transcriptional regulator
B9S66_RS06595	COG0366	Alpha amylase catalytic
B9S66_RS06600	COG0395	ABC-type sugar transport system, permease component
B9S66_RS06605	COG1175	transmembrane transport
B9S66_RS06610	COG2182	Extracellular solute-binding protein
B9S66_RS06615	COG1609	Transcriptional regulator
B9S66_RS06630	COG1228	amidohydrolase
B9S66_RS06650	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B9S66_RS06685	COG0174	glutamine synthetase
B9S66_RS06705	COG2132	Multicopper oxidase
B9S66_RS06710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B9S66_RS06710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9S66_RS06725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B9S66_RS06730	COG1994	Peptidase M50
B9S66_RS06775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B9S66_RS06780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS06785	COG1120	ATPase activity
B9S66_RS06805	COG1834	amidinotransferase
B9S66_RS06815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B9S66_RS06820	COG2814	Major facilitator Superfamily
B9S66_RS06830	COG0076	glutamate decarboxylase activity
B9S66_RS06850	COG0384	phenazine biosynthesis protein PhzF
B9S66_RS06855	COG2226	methyltransferase
B9S66_RS06875	COG1733	regulation of RNA biosynthetic process
B9S66_RS06915	COG3022	response to hydroperoxide
B9S66_RS06920	COG0800	Aldolase
B9S66_RS06925	COG2826	transposase and inactivated derivatives, IS30 family
B9S66_RS06940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B9S66_RS06950	COG1131	(ABC) transporter
B9S66_RS06960	COG4585	Histidine kinase
B9S66_RS06965	COG0346	lactoylglutathione lyase activity
B9S66_RS06970	COG2197	response regulator
B9S66_RS06985	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS06990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B9S66_RS06995	COG0477	Major facilitator Superfamily
B9S66_RS07025	COG0438	transferase activity, transferring glycosyl groups
B9S66_RS07030	COG1657	PFAM Prenyltransferase squalene oxidase
B9S66_RS07045	COG3845	ABC transporter
B9S66_RS07150	COG0586	Pfam SNARE associated Golgi protein
B9S66_RS07165	COG1358	cellular component organization or biogenesis
B9S66_RS07215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B9S66_RS07235	COG4585	Histidine kinase
B9S66_RS07240	COG2197	response regulator
B9S66_RS07255	COG0667	Aldo Keto reductase
B9S66_RS07260	COG0789	Transcriptional regulator
B9S66_RS07280	COG1741	Belongs to the pirin family
B9S66_RS07295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B9S66_RS07300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B9S66_RS07305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B9S66_RS07335	COG1764	response to oxidative stress
B9S66_RS07365	COG1077	Cell shape determining protein MreB Mrl
B9S66_RS07380	COG2890	protein-(glutamine-N5) methyltransferase activity
B9S66_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS07420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9S66_RS07440	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B9S66_RS07450	COG2851	Citrate transporter
B9S66_RS07455	COG4565	transcriptional regulatory protein
B9S66_RS07460	COG3290	protein histidine kinase activity
B9S66_RS07470	COG0358	DNA primase activity
B9S66_RS07475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B9S66_RS07495	COG1070	Carbohydrate kinase
B9S66_RS07535	COG2226	methyltransferase
B9S66_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS07555	COG0738	Major facilitator superfamily
B9S66_RS07565	COG0832	Belongs to the urease beta subunit family
B9S66_RS07570	COG0804	urea catabolic process
B9S66_RS07575	COG0830	nickel cation binding
B9S66_RS07580	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B9S66_RS07585	COG0829	nickel cation binding
B9S66_RS07595	COG1324	tolerance protein
B9S66_RS07610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B9S66_RS07610	COG0574	Belongs to the PEP-utilizing enzyme family
B9S66_RS07650	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B9S66_RS07655	COG1846	Transcriptional regulator
B9S66_RS07655	COG1940	carbohydrate kinase activity
B9S66_RS07660	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B9S66_RS07685	COG3467	pyridoxamine 5'-phosphate
B9S66_RS07695	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B9S66_RS07700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B9S66_RS07715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B9S66_RS07725	COG0189	ligase activity
B9S66_RS07795	COG0423	glycine-tRNA ligase activity
B9S66_RS07805	COG1121	(ABC) transporter
B9S66_RS07810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B9S66_RS07820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B9S66_RS07825	COG1381	Involved in DNA repair and RecF pathway recombination
B9S66_RS07840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B9S66_RS07855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B9S66_RS07865	COG2315	Protein conserved in bacteria
B9S66_RS07875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B9S66_RS07895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9S66_RS07900	COG1486	melibiose metabolic process
B9S66_RS07925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B9S66_RS07930	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B9S66_RS07950	COG1234	tRNA 3'-trailer cleavage
B9S66_RS07955	COG0537	adenosine 5'-monophosphoramidase activity
B9S66_RS07960	COG4946	Tricorn protease homolog
B9S66_RS07960	COG0793	Belongs to the peptidase S41A family
B9S66_RS07975	COG0484	heat shock protein binding
B9S66_RS08010	COG0481	GTPase activity
B9S66_RS08015	COG0268	Binds directly to 16S ribosomal RNA
B9S66_RS08030	COG2353	YceI-like domain
B9S66_RS08045	COG1307	EDD domain protein, DegV family
B9S66_RS08055	COG0495	leucyl-tRNA aminoacylation
B9S66_RS08080	COG0588	phosphoglycerate mutase activity
B9S66_RS08085	COG0799	negative regulation of ribosome biogenesis
B9S66_RS08095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B9S66_RS08100	COG0501	Belongs to the peptidase M48B family
B9S66_RS08120	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B9S66_RS08130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B9S66_RS08150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B9S66_RS08155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B9S66_RS08160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B9S66_RS08165	COG1530	ribonuclease E activity
B9S66_RS08195	COG0772	Belongs to the SEDS family
B9S66_RS08215	COG1077	Cell shape determining protein MreB Mrl
B9S66_RS08220	COG0105	UTP biosynthetic process
B9S66_RS08230	COG0285	dihydrofolate synthase activity
B9S66_RS08235	COG0525	valine-tRNA ligase activity
B9S66_RS08245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B9S66_RS08250	COG0740	serine-type endopeptidase activity
B9S66_RS08255	COG0740	serine-type endopeptidase activity
B9S66_RS08260	COG0544	peptidyl-prolyl cis-trans isomerase activity
B9S66_RS08285	COG3594	Acyltransferase
B9S66_RS08290	COG0475	glutathione-regulated potassium exporter activity
B9S66_RS08300	COG4552	Acetyltransferase involved in intracellular survival and related
B9S66_RS08315	COG1113	amino acid transport
B9S66_RS08320	COG1268	BioY protein
B9S66_RS08325	COG1113	amino acid transport
B9S66_RS08330	COG1113	amino acid transport
B9S66_RS08335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B9S66_RS08340	COG0076	glutamate decarboxylase activity
B9S66_RS08345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B9S66_RS08380	COG4266	Belongs to the allantoicase family
B9S66_RS08425	COG0583	DNA-binding transcription factor activity
B9S66_RS08445	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B9S66_RS08460	COG0668	transmembrane transport
B9S66_RS08470	COG1486	melibiose metabolic process
B9S66_RS08490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9S66_RS08520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B9S66_RS08525	COG0667	Aldo Keto reductase
B9S66_RS08545	COG1136	(ABC) transporter
B9S66_RS08580	COG0629	single-stranded DNA binding
B9S66_RS08650	COG3629	intracellular signal transduction
B9S66_RS08650	COG3903	Transcriptional regulator
B9S66_RS08680	COG1131	(ABC) transporter
B9S66_RS08700	COG3962	Belongs to the TPP enzyme family
B9S66_RS08705	COG3718	enzyme involved in inositol metabolism
B9S66_RS08750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B9S66_RS08755	COG1472	Belongs to the glycosyl hydrolase 3 family
B9S66_RS08775	COG3960	tartronate-semialdehyde synthase activity
B9S66_RS08785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9S66_RS08830	COG1946	Acyl-CoA thioesterase
B9S66_RS08840	COG1309	transcriptional regulator
B9S66_RS08845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B9S66_RS08860	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS08895	COG3655	Transcriptional regulator
B9S66_RS08905	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS08935	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B9S66_RS08960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B9S66_RS08975	COG4977	sequence-specific DNA binding
B9S66_RS08980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B9S66_RS09050	COG0745	RESPONSE REGULATOR receiver
B9S66_RS09075	COG0406	alpha-ribazole phosphatase activity
B9S66_RS09105	COG0709	Synthesizes selenophosphate from selenide and ATP
B9S66_RS09135	COG0012	GTP binding
B9S66_RS09150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B9S66_RS09155	COG0531	amino acid
B9S66_RS09160	COG1570	exodeoxyribonuclease VII activity
B9S66_RS09165	COG1722	exodeoxyribonuclease VII activity
B9S66_RS09170	COG0778	Nitroreductase
B9S66_RS09195	COG0515	serine threonine protein kinase
B9S66_RS09205	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B9S66_RS09205	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B9S66_RS09215	COG0114	fumarate hydratase activity
B9S66_RS09225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B9S66_RS09240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B9S66_RS09260	COG1136	(ABC) transporter
B9S66_RS09270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B9S66_RS09275	COG0450	alkyl hydroperoxide reductase
B9S66_RS09295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B9S66_RS09300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B9S66_RS09305	COG0667	Aldo Keto reductase
B9S66_RS09320	COG3548	integral membrane protein
B9S66_RS09330	COG2304	oxidoreductase activity
B9S66_RS09335	COG0656	L-ascorbic acid biosynthetic process
B9S66_RS09340	COG2814	Major facilitator Superfamily
B9S66_RS09405	COG2894	cell division
B9S66_RS09440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B9S66_RS09530	COG0251	oxidation-reduction process
B9S66_RS09535	COG1414	Transcriptional regulator
B9S66_RS09550	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B9S66_RS09580	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B9S66_RS09600	COG1331	Highly conserved protein containing a thioredoxin domain
B9S66_RS09620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B9S66_RS09655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B9S66_RS09665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B9S66_RS09680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B9S66_RS09685	COG2255	four-way junction helicase activity
B9S66_RS09715	COG2318	DinB family
B9S66_RS09720	COG1064	alcohol dehydrogenase
B9S66_RS09725	COG1136	(ABC) transporter
B9S66_RS09745	COG2986	histidine ammonia-lyase
B9S66_RS09755	COG1024	Enoyl-CoA hydratase
B9S66_RS09760	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B9S66_RS09770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B9S66_RS09780	COG0424	maF-like protein
B9S66_RS09790	COG4770	biotin carboxylase activity
B9S66_RS09825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B9S66_RS09845	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS09890	COG1595	DNA-templated transcription, initiation
B9S66_RS09895	COG0745	RESPONSE REGULATOR receiver
B9S66_RS09900	COG2205	protein histidine kinase activity
B9S66_RS09925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B9S66_RS09950	COG0583	DNA-binding transcription factor activity
B9S66_RS09955	COG2814	Major facilitator Superfamily
B9S66_RS09995	COG1079	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS10000	COG4603	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS10005	COG3845	ABC transporter
B9S66_RS10010	COG1744	ABC transporter substrate-binding protein PnrA-like
B9S66_RS10040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B9S66_RS10055	COG1473	amidohydrolase
B9S66_RS10055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B9S66_RS10065	COG2089	acid synthase
B9S66_RS10070	COG1083	cytidylyl-transferase
B9S66_RS10080	COG1216	Glycosyl transferase, family 2
B9S66_RS10150	COG1595	DNA-templated transcription, initiation
B9S66_RS10155	COG1215	transferase activity, transferring glycosyl groups
B9S66_RS10195	COG2009	succinate dehydrogenase
B9S66_RS10205	COG1053	succinate dehydrogenase
B9S66_RS10210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B9S66_RS10225	COG1309	transcriptional regulator
B9S66_RS10250	COG1408	metallophosphoesterase
B9S66_RS10265	COG1295	ribonuclease BN
B9S66_RS10305	COG0180	Tryptophanyl-tRNA synthetase
B9S66_RS10340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B9S66_RS10350	COG0754	glutathionylspermidine amidase activity
B9S66_RS10360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B9S66_RS10365	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B9S66_RS10380	COG1609	Transcriptional regulator
B9S66_RS10385	COG2362	D-Aminopeptidase
B9S66_RS10410	COG1175	transmembrane transport
B9S66_RS10415	COG0395	ABC-type sugar transport system, permease component
B9S66_RS10445	COG0517	IMP dehydrogenase activity
B9S66_RS10445	COG4175	Glycine betaine
B9S66_RS10455	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS10475	COG0039	L-malate dehydrogenase activity
B9S66_RS10500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B9S66_RS10510	COG0138	bifunctional purine biosynthesis protein purh
B9S66_RS10540	COG0045	succinate-CoA ligase (ADP-forming) activity
B9S66_RS10545	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B9S66_RS10550	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B9S66_RS10555	COG0714	Associated with various cellular activities
B9S66_RS10570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9S66_RS10570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9S66_RS10575	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B9S66_RS10580	COG0739	heme binding
B9S66_RS10580	COG0741	lytic transglycosylase activity
B9S66_RS10580	COG1196	nuclear chromosome segregation
B9S66_RS10585	COG2066	Belongs to the glutaminase family
B9S66_RS10615	COG1522	sequence-specific DNA binding
B9S66_RS10625	COG0791	NLP P60 protein
B9S66_RS10645	COG1228	amidohydrolase
B9S66_RS10655	COG1846	Transcriptional regulator
B9S66_RS10655	COG0456	acetyltransferase
B9S66_RS10700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9S66_RS10705	COG2197	response regulator
B9S66_RS10750	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS10760	COG0519	Catalyzes the synthesis of GMP from XMP
B9S66_RS10760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B9S66_RS10780	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS10830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B9S66_RS10840	COG0516	GMP reductase activity
B9S66_RS10850	COG1595	DNA-templated transcription, initiation
B9S66_RS10855	COG2197	response regulator
B9S66_RS10865	COG0583	DNA-binding transcription factor activity
B9S66_RS10870	COG4221	oxidoreductase activity
B9S66_RS10885	COG0726	polysaccharide deacetylase
B9S66_RS10920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B9S66_RS10945	COG0802	atpase or kinase
B9S66_RS10955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B9S66_RS11020	COG0736	holo-[acyl-carrier-protein] synthase activity
B9S66_RS11035	COG4977	sequence-specific DNA binding
B9S66_RS11050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B9S66_RS11065	COG1072	(Pantothenic acid kinase))
B9S66_RS11070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B9S66_RS11075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B9S66_RS11080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B9S66_RS11090	COG0101	tRNA pseudouridine synthase activity
B9S66_RS11095	COG0203	ribosomal protein L17
B9S66_RS11105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B9S66_RS11110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B9S66_RS11115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B9S66_RS11120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B9S66_RS11130	COG0563	adenylate kinase activity
B9S66_RS11135	COG0201	protein transport
B9S66_RS11140	COG0200	Binds to the 23S rRNA
B9S66_RS11145	COG1841	ribosomal large subunit assembly
B9S66_RS11150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B9S66_RS11155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B9S66_RS11160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B9S66_RS11165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B9S66_RS11175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B9S66_RS11180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B9S66_RS11185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B9S66_RS11190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B9S66_RS11195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B9S66_RS11200	COG0255	Belongs to the universal ribosomal protein uL29 family
B9S66_RS11205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B9S66_RS11210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B9S66_RS11215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B9S66_RS11220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B9S66_RS11225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B9S66_RS11230	COG0089	rRNA binding
B9S66_RS11235	COG0088	Forms part of the polypeptide exit tunnel
B9S66_RS11240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B9S66_RS11245	COG0051	transcription antitermination factor activity, RNA binding
B9S66_RS11255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B9S66_RS11275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B9S66_RS11280	COG0049	tRNA binding
B9S66_RS11285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B9S66_RS11320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B9S66_RS11325	COG0085	RNA polymerase activity
B9S66_RS11335	COG0222	ribosome binding
B9S66_RS11340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B9S66_RS11350	COG0081	regulation of translation
B9S66_RS11375	COG0436	Aminotransferase
B9S66_RS11380	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B9S66_RS11390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B9S66_RS11400	COG2030	dehydratase
B9S66_RS11405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B9S66_RS11420	COG0402	S-adenosylhomocysteine deaminase activity
B9S66_RS11425	COG0702	epimerase
B9S66_RS11440	COG1666	GTP binding
B9S66_RS11445	COG2261	transglycosylase associated protein
B9S66_RS11450	COG3304	Inner membrane component domain
B9S66_RS11455	COG0501	Belongs to the peptidase M48B family
B9S66_RS11460	COG1007	ATP synthesis coupled electron transport
B9S66_RS11470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B9S66_RS11475	COG0713	ATP synthesis coupled electron transport
B9S66_RS11480	COG0839	Belongs to the complex I subunit 6 family
B9S66_RS11485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9S66_RS11490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B9S66_RS11495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9S66_RS11500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9S66_RS11505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9S66_RS11515	COG4585	Histidine kinase
B9S66_RS11520	COG2197	response regulator
B9S66_RS11525	COG0674	pyruvate-flavodoxin oxidoreductase activity
B9S66_RS11525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B9S66_RS11530	COG1013	pyruvate-flavodoxin oxidoreductase activity
B9S66_RS11535	COG1733	regulation of RNA biosynthetic process
B9S66_RS11540	COG0702	epimerase
B9S66_RS11550	COG0488	(ABC) transporter
B9S66_RS11570	COG0142	geranyltranstransferase activity
B9S66_RS11575	COG3104	oligopeptide transport
B9S66_RS11590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B9S66_RS11600	COG0561	phosphatase activity
B9S66_RS11620	COG0514	ATP-dependent DNA helicase (RecQ)
B9S66_RS11625	COG1007	ATP synthesis coupled electron transport
B9S66_RS11635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B9S66_RS11640	COG0713	ATP synthesis coupled electron transport
B9S66_RS11645	COG0839	Belongs to the complex I subunit 6 family
B9S66_RS11650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9S66_RS11655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B9S66_RS11660	COG1034	ATP synthesis coupled electron transport
B9S66_RS11665	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B9S66_RS11675	COG0649	NAD binding
B9S66_RS11680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9S66_RS11685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9S66_RS11710	COG2226	methyltransferase
B9S66_RS11720	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B9S66_RS11770	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B9S66_RS11870	COG1674	ftsk spoiiie
B9S66_RS11875	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B9S66_RS11880	COG1278	Cold shock
B9S66_RS11890	COG0183	Belongs to the thiolase family
B9S66_RS11920	COG3559	Exporter of polyketide antibiotics
B9S66_RS11925	COG1131	(ABC) transporter
B9S66_RS11940	COG1301	dicarboxylic acid transport
B9S66_RS11955	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B9S66_RS11965	COG0163	prenyltransferase activity
B9S66_RS11970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B9S66_RS11975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B9S66_RS11990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B9S66_RS12000	COG0785	Cytochrome C biogenesis protein
B9S66_RS12005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B9S66_RS12015	COG0406	alpha-ribazole phosphatase activity
B9S66_RS12020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B9S66_RS12045	COG2826	transposase and inactivated derivatives, IS30 family
B9S66_RS12080	COG0659	secondary active sulfate transmembrane transporter activity
B9S66_RS12085	COG1690	Belongs to the RtcB family
B9S66_RS12110	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B9S66_RS12115	COG0018	arginyl-trna synthetase
B9S66_RS12120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B9S66_RS12140	COG0113	porphobilinogen synthase activity
B9S66_RS12145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B9S66_RS12145	COG1648	precorrin-2 dehydrogenase activity
B9S66_RS12150	COG0181	hydroxymethylbilane synthase activity
B9S66_RS12155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B9S66_RS12160	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B9S66_RS12215	COG0123	including yeast histone deacetylase and acetoin utilization protein
B9S66_RS12250	COG0180	Tryptophanyl-tRNA synthetase
B9S66_RS12255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B9S66_RS12265	COG1129	ABC transporter
B9S66_RS12265	COG0842	Transport permease protein
B9S66_RS12285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9S66_RS12295	COG0129	dihydroxy-acid dehydratase activity
B9S66_RS12300	COG1309	transcriptional regulator
B9S66_RS12305	COG1082	Xylose isomerase domain protein TIM barrel
B9S66_RS12315	COG0248	Ppx GppA phosphatase
B9S66_RS12350	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B9S66_RS12360	COG0671	phosphoesterase, PA-phosphatase related
B9S66_RS12370	COG1595	DNA-templated transcription, initiation
B9S66_RS12380	COG0745	RESPONSE REGULATOR receiver
B9S66_RS12385	COG2205	protein histidine kinase activity
B9S66_RS12390	COG0739	heme binding
B9S66_RS12420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B9S66_RS12440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B9S66_RS12450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B9S66_RS12455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B9S66_RS12470	COG2197	response regulator
B9S66_RS12485	COG0649	NAD binding
B9S66_RS12505	COG2197	response regulator
B9S66_RS12510	COG4585	Histidine kinase
B9S66_RS12525	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS12590	COG0477	Major facilitator Superfamily
B9S66_RS12605	COG0477	Major facilitator Superfamily
B9S66_RS12615	COG1732	Glycine betaine
B9S66_RS12620	COG1174	glycine betaine transport
B9S66_RS12625	COG1174	glycine betaine transport
B9S66_RS12645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B9S66_RS12650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B9S66_RS12660	COG0302	gtp cyclohydrolase
B9S66_RS12675	COG0037	tRNA processing
B9S66_RS12685	COG2027	D-alanyl-D-alanine carboxypeptidase
B9S66_RS12690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B9S66_RS12700	COG0586	Pfam SNARE associated Golgi protein
B9S66_RS12705	COG0789	Transcriptional regulator
B9S66_RS12710	COG0655	NAD(P)H dehydrogenase (quinone) activity
B9S66_RS12720	COG2318	DinB family
B9S66_RS12725	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS12750	COG1289	transmembrane transporter activity
B9S66_RS12790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B9S66_RS12790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B9S66_RS12795	COG0501	Belongs to the peptidase M48B family
B9S66_RS12825	COG2186	Transcriptional regulator
B9S66_RS12830	COG2828	Protein conserved in bacteria
B9S66_RS12835	COG2159	amidohydrolase
B9S66_RS12850	COG2814	Major facilitator Superfamily
B9S66_RS12850	COG0477	Major facilitator Superfamily
B9S66_RS12865	COG0739	heme binding
B9S66_RS12870	COG1196	nuclear chromosome segregation
B9S66_RS12895	COG1609	Transcriptional regulator
B9S66_RS12900	COG0588	phosphoglycerate mutase activity
B9S66_RS12925	COG0438	transferase activity, transferring glycosyl groups
B9S66_RS12935	COG0791	NLP P60 protein
B9S66_RS12935	COG1388	LysM domain
B9S66_RS12935	COG3103	Sh3 type 3 domain protein
B9S66_RS12960	COG1309	transcriptional regulator
B9S66_RS12980	COG2226	methyltransferase
B9S66_RS12990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9S66_RS13050	COG1476	TRANSCRIPTIONal
B9S66_RS13075	COG0789	Transcriptional regulator
B9S66_RS13090	COG1490	D-aminoacyl-tRNA deacylase activity
B9S66_RS13095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B9S66_RS13100	COG0735	belongs to the Fur family
B9S66_RS13105	COG3485	protocatechuate 3,4-dioxygenase
B9S66_RS13150	COG2897	thiosulfate sulfurtransferase activity
B9S66_RS13175	COG0745	RESPONSE REGULATOR receiver
B9S66_RS13180	COG1609	Transcriptional regulator
B9S66_RS13185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9S66_RS13190	COG0745	RESPONSE REGULATOR receiver
B9S66_RS13205	COG4214	carbohydrate transport
B9S66_RS13210	COG1129	ABC transporter
B9S66_RS13220	COG1609	Transcriptional regulator
B9S66_RS13230	COG2160	L-arabinose isomerase activity
B9S66_RS13235	COG0235	Class ii aldolase
B9S66_RS13240	COG0737	Belongs to the 5'-nucleotidase family
B9S66_RS13245	COG0456	acetyltransferase
B9S66_RS13290	COG4941	Belongs to the sigma-70 factor family
B9S66_RS13295	COG1725	Transcriptional regulator
B9S66_RS13305	COG1131	(ABC) transporter
B9S66_RS13315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B9S66_RS13330	COG1487	ribonuclease activity
B9S66_RS13350	COG2267	carboxylic ester hydrolase activity
B9S66_RS13405	COG1595	DNA-templated transcription, initiation
B9S66_RS13445	COG3629	intracellular signal transduction
B9S66_RS13445	COG3903	Transcriptional regulator
B9S66_RS13450	COG0596	Alpha beta hydrolase
B9S66_RS13460	COG2770	Histidine kinase
B9S66_RS13460	COG2208	phosphoserine phosphatase activity
B9S66_RS13500	COG2318	DinB family
B9S66_RS13505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B9S66_RS13535	COG0494	nUDIX hydrolase
B9S66_RS13535	COG0406	alpha-ribazole phosphatase activity
B9S66_RS13555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B9S66_RS13560	COG0306	phosphate transporter
B9S66_RS13570	COG1937	Protein conserved in bacteria
B9S66_RS13580	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS13595	COG0671	phosphoesterase, PA-phosphatase related
B9S66_RS13600	COG0739	heme binding
B9S66_RS13600	COG0741	lytic transglycosylase activity
B9S66_RS13600	COG1196	nuclear chromosome segregation
B9S66_RS13620	COG2318	DinB family
B9S66_RS13630	COG0509	glycine decarboxylation via glycine cleavage system
B9S66_RS13680	COG0477	Major facilitator Superfamily
B9S66_RS13685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B9S66_RS13690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B9S66_RS13695	COG2124	cytochrome p450
B9S66_RS13715	COG0798	PFAM Bile acid sodium symporter
B9S66_RS13720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B9S66_RS13735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B9S66_RS13750	COG1335	isochorismatase
B9S66_RS13760	COG2197	response regulator
B9S66_RS13765	COG4585	Histidine kinase
B9S66_RS13770	COG0702	epimerase
B9S66_RS13780	COG3844	kynureninase activity
B9S66_RS13800	COG0477	Major facilitator Superfamily
B9S66_RS13805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B9S66_RS13810	COG0191	fructose-bisphosphate aldolase activity
B9S66_RS13815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B9S66_RS13830	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B9S66_RS13880	COG2378	regulation of single-species biofilm formation
B9S66_RS13895	COG0477	Major facilitator Superfamily
B9S66_RS13920	COG0789	Transcriptional regulator
B9S66_RS13925	COG0484	heat shock protein binding
B9S66_RS13930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B9S66_RS13935	COG0443	Heat shock 70 kDa protein
B9S66_RS13970	COG1725	Transcriptional regulator
B9S66_RS13975	COG1131	(ABC) transporter
B9S66_RS13985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B9S66_RS14005	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B9S66_RS14010	COG1404	Belongs to the peptidase S8 family
B9S66_RS14015	COG1120	ATPase activity
B9S66_RS14020	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS14025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS14060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B9S66_RS14060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B9S66_RS14090	COG1695	Transcriptional regulator
B9S66_RS14100	COG2814	Major facilitator Superfamily
B9S66_RS14125	COG0717	Belongs to the dCTP deaminase family
B9S66_RS14165	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B9S66_RS14170	COG0247	lactate metabolic process
B9S66_RS14170	COG2181	nitrate reductase activity
B9S66_RS14175	COG0657	acetylesterase activity
B9S66_RS14200	COG0494	nUDIX hydrolase
B9S66_RS14230	COG0477	Major facilitator Superfamily
B9S66_RS14250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9S66_RS14280	COG2770	Histidine kinase
B9S66_RS14280	COG2208	phosphoserine phosphatase activity
B9S66_RS14285	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B9S66_RS14290	COG1937	Protein conserved in bacteria
B9S66_RS14295	COG2268	Band 7 protein
B9S66_RS14310	COG1316	TRANSCRIPTIONal
B9S66_RS14350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B9S66_RS14360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B9S66_RS14370	COG0628	permease
B9S66_RS14375	COG1741	Belongs to the pirin family
B9S66_RS14385	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS14405	COG1362	aminopeptidase activity
B9S66_RS14460	COG0508	dehydrogenase complex catalyzes the overall conversion of
B9S66_RS14465	COG0022	dehydrogenase e1 component
B9S66_RS14480	COG0515	serine threonine protein kinase
B9S66_RS14485	COG0515	serine threonine protein kinase
B9S66_RS14510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B9S66_RS14515	COG0303	'Molybdopterin
B9S66_RS14520	COG0746	molybdenum cofactor guanylyltransferase activity
B9S66_RS14540	COG1522	sequence-specific DNA binding
B9S66_RS14585	COG1733	regulation of RNA biosynthetic process
B9S66_RS14590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B9S66_RS14600	COG1716	ATPase activity
B9S66_RS14605	COG1716	ATPase activity
B9S66_RS14630	COG0515	serine threonine protein kinase
B9S66_RS14635	COG3764	Sortase (surface protein transpeptidase)
B9S66_RS14640	COG3764	Sortase (surface protein transpeptidase)
B9S66_RS14665	COG0705	Rhomboid family
B9S66_RS14685	COG1309	transcriptional regulator
B9S66_RS14690	COG1278	Cold shock
B9S66_RS14720	COG0515	serine threonine protein kinase
B9S66_RS14760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B9S66_RS14765	COG0187	DNA topoisomerase II activity
B9S66_RS14770	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B9S66_RS14775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B9S66_RS14780	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B9S66_RS14785	COG0592	DNA-directed DNA polymerase activity
B9S66_RS14795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B9S66_RS14800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B9S66_RS14805	COG0594	ribonuclease P activity
B9S66_RS14810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B9S66_RS14815	COG0706	membrane insertase activity
B9S66_RS14825	COG0357	Ribosomal RNA small subunit methyltransferase G
B9S66_RS14830	COG1192	Involved in chromosome partitioning
B9S66_RS14845	COG3118	belongs to the thioredoxin family
B9S66_RS14850	COG0492	ferredoxin-NADP+ reductase activity
B9S66_RS14860	COG1595	DNA-templated transcription, initiation
B9S66_RS14865	COG2815	serine threonine protein kinase
B9S66_RS14865	COG0515	serine threonine protein kinase
B9S66_RS14880	COG0617	tRNA 3'-terminal CCA addition
B9S66_RS14910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B9S66_RS14935	COG0360	Binds together with S18 to 16S ribosomal RNA
B9S66_RS14940	COG0629	single-stranded DNA binding
B9S66_RS14945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B9S66_RS14950	COG0359	binds to the 23S rRNA
B9S66_RS14960	COG0305	Participates in initiation and elongation during chromosome replication
B9S66_RS14965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B9S66_RS14970	COG0110	maltose O-acetyltransferase activity
B9S66_RS15015	COG0626	cystathionine gamma-synthase activity
B9S66_RS15020	COG1950	PFAM Membrane protein of
B9S66_RS15025	COG0662	Cupin 2, conserved barrel domain protein
B9S66_RS15050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B9S66_RS15065	COG1609	Transcriptional regulator
B9S66_RS15070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B9S66_RS15075	COG1271	oxidase subunit
B9S66_RS15080	COG1294	oxidase, subunit
B9S66_RS15085	COG4988	ABC transporter
B9S66_RS15095	COG1196	nuclear chromosome segregation
B9S66_RS15095	COG0741	lytic transglycosylase activity
B9S66_RS15095	COG0739	heme binding
B9S66_RS15100	COG0561	phosphatase activity
B9S66_RS15120	COG1131	(ABC) transporter
B9S66_RS15140	COG0561	phosphatase activity
B9S66_RS15145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B9S66_RS15150	COG0077	Prephenate dehydratase
B9S66_RS15155	COG2837	iron assimilation
B9S66_RS15170	COG1999	signal sequence binding
B9S66_RS15190	COG0006	proline dipeptidase activity
B9S66_RS15205	COG0653	protein targeting
B9S66_RS15225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9S66_RS15245	COG1595	DNA-templated transcription, initiation
B9S66_RS15250	COG0318	PFAM AMP-dependent synthetase and ligase
B9S66_RS15300	COG0477	Major facilitator Superfamily
B9S66_RS15320	COG0477	Major facilitator Superfamily
B9S66_RS15340	COG1191	sigma factor activity
B9S66_RS15345	COG1191	sigma factor activity
B9S66_RS15375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B9S66_RS15445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B9S66_RS15450	COG2837	iron assimilation
B9S66_RS15460	COG0659	secondary active sulfate transmembrane transporter activity
B9S66_RS15485	COG0151	Belongs to the GarS family
B9S66_RS15505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B9S66_RS15515	COG2197	response regulator
B9S66_RS15550	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B9S66_RS15555	COG0047	phosphoribosylformylglycinamidine synthase activity
B9S66_RS15560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B9S66_RS15575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B9S66_RS15610	COG1643	Atp-dependent helicase
B9S66_RS15645	COG0513	Belongs to the DEAD box helicase family
B9S66_RS15675	COG0542	response to heat
B9S66_RS15705	COG0667	Aldo Keto reductase
B9S66_RS15715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B9S66_RS15720	COG0579	oxidoreductase
B9S66_RS15735	COG0366	Alpha amylase catalytic
B9S66_RS15735	COG1470	cell adhesion involved in biofilm formation
B9S66_RS15825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B9S66_RS15880	COG2197	response regulator
B9S66_RS15885	COG4585	Histidine kinase
B9S66_RS15895	COG0666	response to abiotic stimulus
B9S66_RS15905	COG1733	regulation of RNA biosynthetic process
B9S66_RS15970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B9S66_RS15975	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B9S66_RS15985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B9S66_RS16045	COG0596	Alpha beta hydrolase
B9S66_RS16070	COG2318	DinB family
B9S66_RS16085	COG0577	efflux transmembrane transporter activity
B9S66_RS16085	COG1136	(ABC) transporter
B9S66_RS16175	COG1408	metallophosphoesterase
B9S66_RS16185	COG2826	transposase and inactivated derivatives, IS30 family
B9S66_RS16205	COG0003	Pfam Anion-transporting ATPase
B9S66_RS16215	COG0251	oxidation-reduction process
B9S66_RS16225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B9S66_RS16255	COG2267	carboxylic ester hydrolase activity
B9S66_RS16265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9S66_RS16270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B9S66_RS16275	COG0659	secondary active sulfate transmembrane transporter activity
B9S66_RS16335	COG1111	helicase
B9S66_RS16335	COG1205	dead DEAH box helicase
B9S66_RS16340	COG1366	Belongs to the anti-sigma-factor antagonist family
B9S66_RS16355	COG2890	protein-(glutamine-N5) methyltransferase activity
B9S66_RS16365	COG1754	DNA topoisomerase type I activity
B9S66_RS16365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B9S66_RS16370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B9S66_RS16410	COG0537	adenosine 5'-monophosphoramidase activity
B9S66_RS16425	COG2249	NAD(P)H dehydrogenase (quinone) activity
B9S66_RS16455	COG2197	response regulator
B9S66_RS16470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9S66_RS16485	COG0789	Transcriptional regulator
B9S66_RS16500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B9S66_RS16505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B9S66_RS16520	COG0789	Transcriptional regulator
B9S66_RS16530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B9S66_RS16530	COG0825	malonyl-CoA metabolic process
B9S66_RS16535	COG0318	PFAM AMP-dependent synthetase and ligase
B9S66_RS16545	COG2186	Transcriptional regulator
B9S66_RS16575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B9S66_RS16585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B9S66_RS16600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B9S66_RS16650	COG1252	NADH dehydrogenase
B9S66_RS16660	COG0640	Transcriptional regulator
B9S66_RS16670	COG1316	TRANSCRIPTIONal
B9S66_RS16675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B9S66_RS16700	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B9S66_RS16715	COG5001	Diguanylate cyclase
B9S66_RS16735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS16740	COG1120	ATPase activity
B9S66_RS16745	COG0783	Belongs to the Dps family
B9S66_RS16750	COG4942	peptidase
B9S66_RS16780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B9S66_RS16785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B9S66_RS16805	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B9S66_RS16840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B9S66_RS16845	COG2264	protein methyltransferase activity
B9S66_RS16895	COG3311	Transcriptional regulator
B9S66_RS16920	COG2076	Multidrug Resistance protein
B9S66_RS16930	COG5002	protein histidine kinase activity
B9S66_RS16935	COG0745	RESPONSE REGULATOR receiver
B9S66_RS16950	COG1329	Transcriptional regulator
B9S66_RS16955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B9S66_RS16960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B9S66_RS16980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS16995	COG0215	cysteine-tRNA ligase activity
B9S66_RS17010	COG1253	flavin adenine dinucleotide binding
B9S66_RS17020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B9S66_RS17030	COG3842	ATPase activity
B9S66_RS17040	COG2814	Major facilitator Superfamily
B9S66_RS17075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9S66_RS17075	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B9S66_RS17090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9S66_RS17090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9S66_RS17095	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B9S66_RS17095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9S66_RS17100	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B9S66_RS17110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B9S66_RS17120	COG0436	Aminotransferase
B9S66_RS17130	COG0456	acetyltransferase
B9S66_RS17165	COG2208	phosphoserine phosphatase activity
B9S66_RS17165	COG2770	Histidine kinase
B9S66_RS17195	COG1278	Cold shock
B9S66_RS17200	COG0513	Belongs to the DEAD box helicase family
B9S66_RS17220	COG0301	tRNA thio-modification
B9S66_RS17240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B9S66_RS17245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B9S66_RS17250	COG2197	response regulator
B9S66_RS17255	COG4585	Histidine kinase
B9S66_RS17265	COG2409	Drug exporters of the RND superfamily
B9S66_RS17315	COG0577	efflux transmembrane transporter activity
B9S66_RS17320	COG1136	(ABC) transporter
B9S66_RS17320	COG0577	efflux transmembrane transporter activity
B9S66_RS17345	COG2172	sigma factor antagonist activity
B9S66_RS17350	COG1366	Belongs to the anti-sigma-factor antagonist family
B9S66_RS17355	COG1366	Belongs to the anti-sigma-factor antagonist family
B9S66_RS17435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B9S66_RS17495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9S66_RS17530	COG1136	(ABC) transporter
B9S66_RS17530	COG0577	efflux transmembrane transporter activity
B9S66_RS17545	COG1309	transcriptional regulator
B9S66_RS17575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B9S66_RS17600	COG1105	Belongs to the carbohydrate kinase PfkB family
B9S66_RS17640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B9S66_RS17670	COG0463	Glycosyl transferase, family 2
B9S66_RS17685	COG1278	Cold shock
B9S66_RS17725	COG0667	Aldo Keto reductase
B9S66_RS17730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B9S66_RS17730	COG1263	PTS System
B9S66_RS17735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B9S66_RS17740	COG1737	Transcriptional regulator
B9S66_RS17750	COG0406	alpha-ribazole phosphatase activity
B9S66_RS17815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B9S66_RS17835	COG2197	response regulator
B9S66_RS17840	COG4585	Histidine kinase
B9S66_RS17890	COG3973	AAA domain
B9S66_RS17915	COG0789	Transcriptional regulator
B9S66_RS17920	COG0667	Aldo Keto reductase
B9S66_RS17955	COG1061	Type III restriction enzyme res subunit
B9S66_RS18015	COG2124	cytochrome p450
B9S66_RS18025	COG1295	ribonuclease BN
B9S66_RS18035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS18040	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS18045	COG1120	ATPase activity
B9S66_RS18050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B9S66_RS18055	COG0515	serine threonine protein kinase
B9S66_RS18065	COG1132	(ABC) transporter
B9S66_RS18070	COG1132	(ABC) transporter
B9S66_RS18075	COG2197	response regulator
B9S66_RS18085	COG1278	Cold shock
B9S66_RS18090	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B9S66_RS18095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B9S66_RS18105	COG2814	Major facilitator Superfamily
B9S66_RS18130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B9S66_RS18140	COG2252	PERMEase
B9S66_RS18165	COG0667	Aldo Keto reductase
B9S66_RS18270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B9S66_RS18280	COG2124	cytochrome p450
B9S66_RS18300	COG2205	protein histidine kinase activity
B9S66_RS18305	COG0247	lactate metabolic process
B9S66_RS18305	COG0277	FAD linked oxidase domain protein
B9S66_RS18315	COG0583	DNA-binding transcription factor activity
B9S66_RS18350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B9S66_RS18365	COG1024	Enoyl-CoA hydratase
B9S66_RS18385	COG0259	pyridoxamine-phosphate oxidase activity
B9S66_RS18395	COG4821	SIS domain
B9S66_RS18475	COG1366	Belongs to the anti-sigma-factor antagonist family
B9S66_RS18495	COG2271	Major facilitator Superfamily
B9S66_RS18500	COG2072	flavoprotein involved in K transport
B9S66_RS18520	COG1309	transcriptional regulator
B9S66_RS18525	COG0515	serine threonine protein kinase
B9S66_RS18525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B9S66_RS18560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B9S66_RS18600	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B9S66_RS18615	COG0148	phosphopyruvate hydratase activity
B9S66_RS18635	COG5297	Belongs to the glycosyl hydrolase family 6
B9S66_RS18715	COG1278	Cold shock
B9S66_RS18745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B9S66_RS18780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B9S66_RS18785	COG2151	metal-sulfur cluster biosynthetic enzyme
B9S66_RS18790	COG3396	Phenylacetate-CoA oxygenase
B9S66_RS18795	COG3460	Phenylacetate-CoA oxygenase
B9S66_RS18800	COG3396	Phenylacetate-CoA oxygenase
B9S66_RS18805	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9S66_RS18810	COG1024	Enoyl-CoA hydratase
B9S66_RS18815	COG0183	Belongs to the thiolase family
B9S66_RS18825	COG2050	protein possibly involved in aromatic compounds catabolism
B9S66_RS18880	COG1846	Transcriptional regulator
B9S66_RS18885	COG3384	dioxygenase
B9S66_RS18905	COG3191	aminopeptidase activity
B9S66_RS18920	COG1970	mechanosensitive ion channel activity
B9S66_RS18930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B9S66_RS18945	COG3263	regulation of cellular component size
B9S66_RS18955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B9S66_RS18960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B9S66_RS18970	COG0315	cyclic pyranopterin monophosphate synthase activity
B9S66_RS18975	COG0315	cyclic pyranopterin monophosphate synthase activity
B9S66_RS18975	COG0521	Mo-molybdopterin cofactor biosynthetic process
B9S66_RS19015	COG2197	response regulator
B9S66_RS19035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B9S66_RS19045	COG0708	Exodeoxyribonuclease III
B9S66_RS19060	COG2072	flavoprotein involved in K transport
B9S66_RS19070	COG4221	oxidoreductase activity
B9S66_RS19080	COG4946	Tricorn protease homolog
B9S66_RS19080	COG0793	Belongs to the peptidase S41A family
B9S66_RS19090	COG2409	Drug exporters of the RND superfamily
B9S66_RS19100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B9S66_RS19170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B9S66_RS19265	COG2186	Transcriptional regulator
B9S66_RS19290	COG0084	hydrolase, TatD family'
B9S66_RS19295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B9S66_RS19300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B9S66_RS19305	COG0488	(ABC) transporter
B9S66_RS19350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B9S66_RS19355	COG2197	response regulator
B9S66_RS19365	COG4106	trans-aconitate 2-methyltransferase activity
B9S66_RS19385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B9S66_RS19395	COG0193	aminoacyl-tRNA hydrolase activity
B9S66_RS19400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B9S66_RS19425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B9S66_RS19430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B9S66_RS19440	COG4585	Histidine kinase
B9S66_RS19465	COG0789	Transcriptional regulator
B9S66_RS19485	COG1316	TRANSCRIPTIONal
B9S66_RS19495	COG0596	Alpha beta hydrolase
B9S66_RS19535	COG0477	Major facilitator Superfamily
B9S66_RS19545	COG3629	intracellular signal transduction
B9S66_RS19545	COG3903	Transcriptional regulator
B9S66_RS19600	COG1473	amidohydrolase
B9S66_RS19610	COG3226	Transcriptional regulator
B9S66_RS19615	COG0154	amidase activity
B9S66_RS19660	COG1733	regulation of RNA biosynthetic process
B9S66_RS19715	COG0148	phosphopyruvate hydratase activity
B9S66_RS19745	COG1252	NADH dehydrogenase
B9S66_RS19750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B9S66_RS19755	COG0577	efflux transmembrane transporter activity
B9S66_RS19755	COG1136	(ABC) transporter
B9S66_RS19760	COG1136	(ABC) transporter
B9S66_RS19770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B9S66_RS19785	COG1476	TRANSCRIPTIONal
B9S66_RS19805	COG0183	Belongs to the thiolase family
B9S66_RS19810	COG2755	lipolytic protein G-D-S-L family
B9S66_RS19870	COG0395	ABC-type sugar transport system, permease component
B9S66_RS19890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B9S66_RS19900	COG1228	amidohydrolase
B9S66_RS19905	COG1191	sigma factor activity
B9S66_RS19910	COG1366	Belongs to the anti-sigma-factor antagonist family
B9S66_RS19920	COG3104	oligopeptide transport
B9S66_RS19925	COG0745	RESPONSE REGULATOR receiver
B9S66_RS19930	COG2205	protein histidine kinase activity
B9S66_RS19945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B9S66_RS19970	COG2072	flavoprotein involved in K transport
B9S66_RS19980	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B9S66_RS20020	COG0753	catalase activity
B9S66_RS20070	COG3046	protein related to deoxyribodipyrimidine photolyase
B9S66_RS20075	COG1316	TRANSCRIPTIONal
B9S66_RS20095	COG1316	TRANSCRIPTIONal
B9S66_RS20125	COG0778	Nitroreductase
B9S66_RS20125	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B9S66_RS20130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B9S66_RS20170	COG1620	l-lactate permease
B9S66_RS20180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B9S66_RS20195	COG2835	tetraacyldisaccharide 4'-kinase activity
B9S66_RS20205	COG1482	cell wall glycoprotein biosynthetic process
B9S66_RS20215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B9S66_RS20255	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B9S66_RS20260	COG0714	Associated with various cellular activities
B9S66_RS20280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B9S66_RS20285	COG0745	RESPONSE REGULATOR receiver
B9S66_RS20290	COG5002	protein histidine kinase activity
B9S66_RS20295	COG0823	Involved in the tonB-independent uptake of proteins
B9S66_RS20305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B9S66_RS20310	COG2197	response regulator
B9S66_RS20315	COG3214	Protein conserved in bacteria
B9S66_RS20320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B9S66_RS20325	COG0653	protein targeting
B9S66_RS20345	COG0583	DNA-binding transcription factor activity
B9S66_RS20365	COG2902	Dehydrogenase
B9S66_RS20380	COG2226	methyltransferase
B9S66_RS20390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B9S66_RS20395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B9S66_RS20400	COG0438	transferase activity, transferring glycosyl groups
B9S66_RS20405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B9S66_RS20410	COG0395	ABC-type sugar transport system, permease component
B9S66_RS20415	COG1175	transmembrane transport
B9S66_RS20420	COG1653	transport
B9S66_RS20425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B9S66_RS20430	COG1716	ATPase activity
B9S66_RS20455	COG0515	serine threonine protein kinase
B9S66_RS20460	COG0515	serine threonine protein kinase
B9S66_RS20465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B9S66_RS20480	COG2884	Cell division ATP-binding protein ftsE
B9S66_RS20490	COG0793	Belongs to the peptidase S41A family
B9S66_RS20495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B9S66_RS20510	COG0583	DNA-binding transcription factor activity
B9S66_RS20555	COG3973	AAA domain
B9S66_RS20555	COG3973	AAA domain
B9S66_RS20565	COG0776	regulation of translation
B9S66_RS20570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B9S66_RS20575	COG1678	Uncharacterized ACR, COG1678
B9S66_RS20590	COG1175	transmembrane transport
B9S66_RS20595	COG0395	ABC-type sugar transport system, permease component
B9S66_RS20600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B9S66_RS20615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B9S66_RS20640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B9S66_RS20665	COG2318	DinB family
B9S66_RS20685	COG1116	anion transmembrane transporter activity
B9S66_RS20730	COG1174	glycine betaine transport
B9S66_RS20735	COG0517	IMP dehydrogenase activity
B9S66_RS20735	COG1125	glycine betaine transport
B9S66_RS20740	COG1174	glycine betaine transport
B9S66_RS20750	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B9S66_RS20760	COG0277	FAD linked oxidase domain protein
B9S66_RS20795	COG1335	isochorismatase
B9S66_RS20805	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B9S66_RS20820	COG1113	amino acid transport
B9S66_RS20840	COG1234	tRNA 3'-trailer cleavage
B9S66_RS20850	COG1263	PTS System
B9S66_RS20855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B9S66_RS20860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B9S66_RS20870	COG1131	(ABC) transporter
B9S66_RS20880	COG3851	Histidine kinase
B9S66_RS20885	COG2197	response regulator
B9S66_RS20890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B9S66_RS20915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B9S66_RS20925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B9S66_RS20955	COG2733	membrane
B9S66_RS20985	COG0706	membrane insertase activity
B9S66_RS20990	COG0179	Fumarylacetoacetate (FAA) hydrolase
B9S66_RS20995	COG0673	inositol 2-dehydrogenase activity
B9S66_RS21025	COG2826	transposase and inactivated derivatives, IS30 family
B9S66_RS21055	COG3397	chitin binding
B9S66_RS21085	COG1126	abc transporter atp-binding protein
B9S66_RS21090	COG0765	amino acid transport
B9S66_RS21095	COG0765	amino acid transport
B9S66_RS21100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9S66_RS21120	COG3473	Maleate cis-trans isomerase
B9S66_RS21130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9S66_RS21135	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS21195	COG1554	hydrolase, family 65, central catalytic
B9S66_RS21250	COG1217	gtp-binding protein TYPA
B9S66_RS21260	COG0601	transmembrane transport
B9S66_RS21265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS21270	COG0444	Belongs to the ABC transporter superfamily
B9S66_RS21275	COG4608	Belongs to the ABC transporter superfamily
B9S66_RS21285	COG0601	transmembrane transport
B9S66_RS21290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS21300	COG4608	Belongs to the ABC transporter superfamily
B9S66_RS21325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B9S66_RS21350	COG3250	beta-galactosidase activity
B9S66_RS21355	COG1879	ABC-type sugar transport system periplasmic component
B9S66_RS21360	COG1129	ABC transporter
B9S66_RS21370	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS21375	COG1609	Transcriptional regulator
B9S66_RS21385	COG2912	Transglutaminase-like superfamily
B9S66_RS21390	COG0456	acetyltransferase
B9S66_RS21420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B9S66_RS21455	COG0519	Catalyzes the synthesis of GMP from XMP
B9S66_RS21465	COG1024	Enoyl-CoA hydratase
B9S66_RS21480	COG1595	DNA-templated transcription, initiation
B9S66_RS21490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9S66_RS21495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B9S66_RS21535	COG0598	Magnesium transport protein CorA
B9S66_RS21545	COG2814	Major facilitator Superfamily
B9S66_RS21550	COG0613	PHP domain protein
B9S66_RS21555	COG2095	MarC family integral membrane protein
B9S66_RS21560	COG1432	Conserved Protein
B9S66_RS21570	COG0513	Belongs to the DEAD box helicase family
B9S66_RS21665	COG0210	DNA helicase
B9S66_RS21705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B9S66_RS21765	COG3480	Lon protease (S16) C-terminal proteolytic domain
B9S66_RS21775	COG1615	UPF0182 protein
B9S66_RS21800	COG0753	catalase activity
B9S66_RS21805	COG0483	inositol monophosphate 1-phosphatase activity
B9S66_RS21815	COG2076	Multidrug Resistance protein
B9S66_RS21825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B9S66_RS21835	COG2135	peptidase activity
B9S66_RS21845	COG1595	DNA-templated transcription, initiation
B9S66_RS21850	COG5662	AntiSigma factor
B9S66_RS21860	COG0242	peptide deformylase activity
B9S66_RS21870	COG2124	cytochrome p450
B9S66_RS21890	COG1966	Carbon starvation protein
B9S66_RS21895	COG2188	Transcriptional regulator
B9S66_RS21900	COG2182	Extracellular solute-binding protein
B9S66_RS21905	COG1175	transmembrane transport
B9S66_RS21910	COG0395	ABC-type sugar transport system, permease component
B9S66_RS21915	COG1472	Belongs to the glycosyl hydrolase 3 family
B9S66_RS21920	COG0363	glucosamine-6-phosphate deaminase activity
B9S66_RS21940	COG1597	lipid kinase activity
B9S66_RS21955	COG2172	sigma factor antagonist activity
B9S66_RS21970	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B9S66_RS21990	COG1959	2 iron, 2 sulfur cluster binding
B9S66_RS21995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B9S66_RS22005	COG0142	geranyltranstransferase activity
B9S66_RS22055	COG4106	trans-aconitate 2-methyltransferase activity
B9S66_RS22060	COG1126	abc transporter atp-binding protein
B9S66_RS22080	COG0281	malic enzyme
B9S66_RS22085	COG0604	alcohol dehydrogenase
B9S66_RS22130	COG2255	four-way junction helicase activity
B9S66_RS22160	COG0508	dehydrogenase complex catalyzes the overall conversion of
B9S66_RS22160	COG0567	Dehydrogenase, E1 component
B9S66_RS22165	COG2205	protein histidine kinase activity
B9S66_RS22170	COG0745	RESPONSE REGULATOR receiver
B9S66_RS22190	COG1131	(ABC) transporter
B9S66_RS22215	COG0477	Major facilitator Superfamily
B9S66_RS22220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B9S66_RS22225	COG0726	polysaccharide deacetylase
B9S66_RS22305	COG0772	Belongs to the SEDS family
B9S66_RS22320	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B9S66_RS22325	COG2267	carboxylic ester hydrolase activity
B9S66_RS22335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9S66_RS22335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B9S66_RS22340	COG1191	sigma factor activity
B9S66_RS22350	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS22375	COG0018	arginyl-trna synthetase
B9S66_RS22380	COG0019	diaminopimelate decarboxylase activity
B9S66_RS22385	COG0460	homoserine dehydrogenase
B9S66_RS22390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B9S66_RS22395	COG0083	homoserine kinase activity
B9S66_RS22405	COG1316	TRANSCRIPTIONal
B9S66_RS22410	COG0254	rRNA binding
B9S66_RS22415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B9S66_RS22420	COG2890	protein-(glutamine-N5) methyltransferase activity
B9S66_RS22430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B9S66_RS22435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B9S66_RS22450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B9S66_RS22455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B9S66_RS22460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B9S66_RS22465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B9S66_RS22470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B9S66_RS22475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B9S66_RS22480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B9S66_RS22500	COG2197	response regulator
B9S66_RS22505	COG4585	Histidine kinase
B9S66_RS22520	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9S66_RS22535	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B9S66_RS22570	COG1131	(ABC) transporter
B9S66_RS22590	COG0183	Belongs to the thiolase family
B9S66_RS22620	COG1335	isochorismatase
B9S66_RS22695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9S66_RS22695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9S66_RS22740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B9S66_RS22745	COG0857	belongs to the CobB CobQ family
B9S66_RS22745	COG0280	phosphate acetyltransferase
B9S66_RS22750	COG0205	6-phosphofructokinase activity
B9S66_RS22755	COG4565	transcriptional regulatory protein
B9S66_RS22760	COG3290	protein histidine kinase activity
B9S66_RS22765	COG1301	dicarboxylic acid transport
B9S66_RS22790	COG1119	ATPase activity
B9S66_RS22805	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B9S66_RS22810	COG3281	Trehalose synthase
B9S66_RS22815	COG0366	Alpha amylase catalytic
B9S66_RS22820	COG0366	Alpha amylase catalytic
B9S66_RS22840	COG1733	regulation of RNA biosynthetic process
B9S66_RS22850	COG1132	(ABC) transporter
B9S66_RS22855	COG1132	(ABC) transporter
B9S66_RS22880	COG1376	ErfK ybiS ycfS ynhG family protein
B9S66_RS22905	COG2085	NADP oxidoreductase coenzyme F420-dependent
B9S66_RS22930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9S66_RS22945	COG0477	Major facilitator Superfamily
B9S66_RS22960	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B9S66_RS22965	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B9S66_RS22970	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B9S66_RS22985	COG1760	l-serine dehydratase
B9S66_RS22990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B9S66_RS22995	COG0509	glycine decarboxylation via glycine cleavage system
B9S66_RS23000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B9S66_RS23020	COG0747	negative chemotaxis
B9S66_RS23025	COG0601	transmembrane transport
B9S66_RS23030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS23035	COG0444	Belongs to the ABC transporter superfamily
B9S66_RS23040	COG4608	Belongs to the ABC transporter superfamily
B9S66_RS23045	COG2860	membrane
B9S66_RS23070	COG0482	sulfurtransferase activity
B9S66_RS23090	COG4221	oxidoreductase activity
B9S66_RS23100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B9S66_RS23110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B9S66_RS23115	COG0154	amidase activity
B9S66_RS23125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B9S66_RS23130	COG2409	Drug exporters of the RND superfamily
B9S66_RS23145	COG2197	response regulator
B9S66_RS23160	COG2133	pyrroloquinoline quinone binding
B9S66_RS23165	COG0667	Aldo Keto reductase
B9S66_RS23185	COG0440	acetolactate synthase activity
B9S66_RS23190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B9S66_RS23200	COG2890	protein-(glutamine-N5) methyltransferase activity
B9S66_RS23220	COG3835	regulator
B9S66_RS23225	COG0506	proline dehydrogenase activity
B9S66_RS23230	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS23245	COG0575	Belongs to the CDS family
B9S66_RS23255	COG0473	3-isopropylmalate dehydrogenase activity
B9S66_RS23260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B9S66_RS23265	COG0831	urea catabolic process
B9S66_RS23265	COG0832	Belongs to the urease beta subunit family
B9S66_RS23270	COG0804	urea catabolic process
B9S66_RS23275	COG2957	Belongs to the agmatine deiminase family
B9S66_RS23280	COG0477	Major facilitator Superfamily
B9S66_RS23290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B9S66_RS23325	COG4221	oxidoreductase activity
B9S66_RS23345	COG0789	Transcriptional regulator
B9S66_RS23385	COG2353	YceI-like domain
B9S66_RS23395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B9S66_RS23415	COG2018	Roadblock/LC7 domain
B9S66_RS23440	COG2018	Roadblock/LC7 domain
B9S66_RS23455	COG0179	Fumarylacetoacetate (FAA) hydrolase
B9S66_RS23460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B9S66_RS23505	COG1414	Transcriptional regulator
B9S66_RS23510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B9S66_RS23515	COG0066	3-isopropylmalate dehydratase activity
B9S66_RS23525	COG0776	regulation of translation
B9S66_RS23535	COG1920	GTP binding
B9S66_RS23545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B9S66_RS23550	COG1181	Belongs to the D-alanine--D-alanine ligase family
B9S66_RS23570	COG0351	phosphomethylpyrimidine kinase
B9S66_RS23575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B9S66_RS23580	COG1461	Dihydroxyacetone kinase
B9S66_RS23590	COG0742	ribosomal rna small subunit methyltransferase
B9S66_RS23595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B9S66_RS23610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B9S66_RS23615	COG0571	ribonuclease III activity
B9S66_RS23620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B9S66_RS23630	COG2188	Transcriptional regulator
B9S66_RS23660	COG2340	Cysteine-rich secretory protein family
B9S66_RS23665	COG1254	Belongs to the acylphosphatase family
B9S66_RS23680	COG1196	nuclear chromosome segregation
B9S66_RS23685	COG0477	Major facilitator Superfamily
B9S66_RS23715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B9S66_RS23725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B9S66_RS23740	COG0228	four-way junction DNA binding
B9S66_RS23745	COG1837	Belongs to the UPF0109 family
B9S66_RS23755	COG0336	Belongs to the RNA methyltransferase TrmD family
B9S66_RS23760	COG0335	large ribosomal subunit rRNA binding
B9S66_RS23765	COG0681	Belongs to the peptidase S26 family
B9S66_RS23775	COG0681	Belongs to the peptidase S26 family
B9S66_RS23780	COG0681	Belongs to the peptidase S26 family
B9S66_RS23795	COG0792	nuclease activity
B9S66_RS23810	COG1191	sigma factor activity
B9S66_RS23825	COG0052	Belongs to the universal ribosomal protein uS2 family
B9S66_RS23830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B9S66_RS23835	COG0528	UMP kinase activity
B9S66_RS23840	COG0233	cytoplasmic translational termination
B9S66_RS23845	COG0575	Belongs to the CDS family
B9S66_RS23850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B9S66_RS23860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B9S66_RS23865	COG3842	ATPase activity
B9S66_RS23890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B9S66_RS23900	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS23920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B9S66_RS23935	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS23945	COG3842	ATPase activity
B9S66_RS23950	COG1176	ABC-type spermidine putrescine transport system, permease component I
B9S66_RS23955	COG1177	transmembrane transport
B9S66_RS23960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9S66_RS23990	COG2508	Transcriptional regulator
B9S66_RS23995	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS24000	COG1940	carbohydrate kinase activity
B9S66_RS24005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B9S66_RS24010	COG0750	zinc metalloprotease
B9S66_RS24015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B9S66_RS24030	COG0747	negative chemotaxis
B9S66_RS24035	COG0601	transmembrane transport
B9S66_RS24040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS24060	COG0442	prolyl-tRNA aminoacylation
B9S66_RS24080	COG0779	Required for maturation of 30S ribosomal subunits
B9S66_RS24095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B9S66_RS24105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B9S66_RS24110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B9S66_RS24125	COG1357	PFAM Pentapeptide repeats (8 copies)
B9S66_RS24130	COG4608	Belongs to the ABC transporter superfamily
B9S66_RS24135	COG0444	Belongs to the ABC transporter superfamily
B9S66_RS24140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS24145	COG0601	transmembrane transport
B9S66_RS24150	COG0747	negative chemotaxis
B9S66_RS24155	COG0455	bacterial-type flagellum organization
B9S66_RS24165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B9S66_RS24170	COG1185	polyribonucleotide nucleotidyltransferase activity
B9S66_RS24175	COG0612	Peptidase, M16
B9S66_RS24180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B9S66_RS24200	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B9S66_RS24205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B9S66_RS24210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B9S66_RS24245	COG2770	Histidine kinase
B9S66_RS24245	COG2208	phosphoserine phosphatase activity
B9S66_RS24255	COG3850	Histidine kinase
B9S66_RS24255	COG4999	Histidine kinase
B9S66_RS24255	COG3437	response regulator, receiver
B9S66_RS24255	COG2205	protein histidine kinase activity
B9S66_RS24265	COG1674	ftsk spoiiie
B9S66_RS24275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B9S66_RS24285	COG1058	Belongs to the CinA family
B9S66_RS24285	COG1546	Belongs to the CinA family
B9S66_RS24290	COG1396	sequence-specific DNA binding
B9S66_RS24295	COG0783	Belongs to the Dps family
B9S66_RS24305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B9S66_RS24325	COG0596	Alpha beta hydrolase
B9S66_RS24330	COG1201	RNA secondary structure unwinding
B9S66_RS24355	COG0628	permease
B9S66_RS24380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B9S66_RS24385	COG2137	regulation of response to DNA damage stimulus
B9S66_RS24390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B9S66_RS24405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9S66_RS24410	COG0765	amino acid transport
B9S66_RS24415	COG0765	amino acid transport
B9S66_RS24420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9S66_RS24425	COG1126	abc transporter atp-binding protein
B9S66_RS24430	COG0745	RESPONSE REGULATOR receiver
B9S66_RS24435	COG2205	protein histidine kinase activity
B9S66_RS24445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B9S66_RS24465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B9S66_RS24475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B9S66_RS24480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B9S66_RS24490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B9S66_RS24530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9S66_RS24535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B9S66_RS24540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B9S66_RS24565	COG0588	phosphoglycerate mutase activity
B9S66_RS24580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B9S66_RS24615	COG1802	Transcriptional regulator
B9S66_RS24620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B9S66_RS24655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9S66_RS24670	COG1653	transport
B9S66_RS24675	COG1175	transmembrane transport
B9S66_RS24680	COG0395	ABC-type sugar transport system, permease component
B9S66_RS24685	COG0366	Alpha amylase catalytic
B9S66_RS24695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B9S66_RS24700	COG0612	Peptidase, M16
B9S66_RS24715	COG1802	Transcriptional regulator
B9S66_RS24720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B9S66_RS24770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B9S66_RS24775	COG0483	inositol monophosphate 1-phosphatase activity
B9S66_RS24780	COG0745	RESPONSE REGULATOR receiver
B9S66_RS24785	COG2205	protein histidine kinase activity
B9S66_RS24810	COG0756	dUTP diphosphatase activity
B9S66_RS24830	COG1136	(ABC) transporter
B9S66_RS24860	COG0569	domain protein
B9S66_RS24865	COG0531	amino acid
B9S66_RS24915	COG2175	clavaminate synthase activity
B9S66_RS24925	COG3251	PFAM MbtH domain protein
B9S66_RS24935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B9S66_RS24945	COG2197	response regulator
B9S66_RS24955	COG1136	(ABC) transporter
B9S66_RS24955	COG0577	efflux transmembrane transporter activity
B9S66_RS24965	COG2197	response regulator
B9S66_RS24970	COG0438	transferase activity, transferring glycosyl groups
B9S66_RS24985	COG1063	alcohol dehydrogenase
B9S66_RS24990	COG0395	ABC-type sugar transport system, permease component
B9S66_RS25025	COG0559	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS25040	COG0402	S-adenosylhomocysteine deaminase activity
B9S66_RS25045	COG2233	PERMEase
B9S66_RS25100	COG0300	oxidoreductase activity
B9S66_RS25105	COG4221	oxidoreductase activity
B9S66_RS25120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B9S66_RS25130	COG0583	DNA-binding transcription factor activity
B9S66_RS25175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B9S66_RS25200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B9S66_RS25235	COG0656	L-ascorbic acid biosynthetic process
B9S66_RS25250	COG0473	3-isopropylmalate dehydrogenase activity
B9S66_RS25260	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B9S66_RS25290	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS25305	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS25325	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS25335	COG0252	asparaginase activity
B9S66_RS25340	COG1846	Transcriptional regulator
B9S66_RS25340	COG1940	carbohydrate kinase activity
B9S66_RS25345	COG1129	ABC transporter
B9S66_RS25350	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS25355	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS25360	COG4213	ABC transporter substrate-binding protein
B9S66_RS25375	COG0738	Major facilitator superfamily
B9S66_RS25380	COG3226	Transcriptional regulator
B9S66_RS25430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B9S66_RS25450	COG0640	Transcriptional regulator
B9S66_RS25460	COG0789	Transcriptional regulator
B9S66_RS25475	COG2050	protein possibly involved in aromatic compounds catabolism
B9S66_RS25485	COG3540	Alkaline phosphatase
B9S66_RS25505	COG2936	dipeptidyl-peptidase activity
B9S66_RS25520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B9S66_RS25535	COG1309	transcriptional regulator
B9S66_RS25545	COG0747	negative chemotaxis
B9S66_RS25555	COG0601	transmembrane transport
B9S66_RS25560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS25580	COG1733	regulation of RNA biosynthetic process
B9S66_RS25590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS25595	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS25600	COG1120	ATPase activity
B9S66_RS25615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B9S66_RS25625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B9S66_RS25665	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B9S66_RS25675	COG1620	l-lactate permease
B9S66_RS25680	COG0247	lactate metabolic process
B9S66_RS25685	COG1139	Iron-sulfur cluster binding protein
B9S66_RS25690	COG1556	Lactate utilization protein
B9S66_RS25705	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B9S66_RS25715	COG1799	cell septum assembly
B9S66_RS25755	COG2235	arginine
B9S66_RS25760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B9S66_RS25765	COG0531	amino acid
B9S66_RS25795	COG2124	cytochrome p450
B9S66_RS25805	COG2111	Na H antiporter
B9S66_RS25805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B9S66_RS25810	COG1006	Multisubunit Na H antiporter MnhC subunit
B9S66_RS25815	COG0651	ATP synthesis coupled electron transport
B9S66_RS25830	COG1320	monovalent cation:proton antiporter activity
B9S66_RS25835	COG2235	arginine
B9S66_RS25855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B9S66_RS25860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS25865	COG1120	ATPase activity
B9S66_RS25915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B9S66_RS25940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B9S66_RS25945	COG1653	transport
B9S66_RS25950	COG1175	transmembrane transport
B9S66_RS25955	COG0395	ABC-type sugar transport system, permease component
B9S66_RS25965	COG4213	ABC transporter substrate-binding protein
B9S66_RS25975	COG4214	carbohydrate transport
B9S66_RS25980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B9S66_RS25985	COG0531	amino acid
B9S66_RS26005	COG1024	Enoyl-CoA hydratase
B9S66_RS26005	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9S66_RS26010	COG0183	Belongs to the thiolase family
B9S66_RS26030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B9S66_RS26035	COG0446	pyridine nucleotide-disulphide oxidoreductase
B9S66_RS26045	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B9S66_RS26050	COG3253	May function as heme-dependent peroxidase
B9S66_RS26065	COG3220	belongs to the UPF0276 family
B9S66_RS26075	COG0726	polysaccharide deacetylase
B9S66_RS26090	COG1595	DNA-templated transcription, initiation
B9S66_RS26095	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B9S66_RS26115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B9S66_RS26120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B9S66_RS26190	COG5002	protein histidine kinase activity
B9S66_RS26190	COG2176	DNA-directed DNA polymerase activity
B9S66_RS26225	COG0386	Belongs to the glutathione peroxidase family
B9S66_RS26240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9S66_RS26245	COG1116	anion transmembrane transporter activity
B9S66_RS26270	COG0529	Catalyzes the synthesis of activated sulfate
B9S66_RS26275	COG0175	sulfate reduction
B9S66_RS26285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9S66_RS26310	COG0604	alcohol dehydrogenase
B9S66_RS26320	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS26340	COG2040	homocysteine
B9S66_RS26365	COG2255	four-way junction helicase activity
B9S66_RS26375	COG1120	ATPase activity
B9S66_RS26380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS26390	COG2409	Drug exporters of the RND superfamily
B9S66_RS26395	COG1846	Transcriptional regulator
B9S66_RS26400	COG0702	epimerase
B9S66_RS26410	COG0789	Transcriptional regulator
B9S66_RS26420	COG1595	DNA-templated transcription, initiation
B9S66_RS26460	COG2365	Tyrosine phosphatase family
B9S66_RS26470	COG1162	GTPase activity
B9S66_RS26475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B9S66_RS26495	COG0028	Belongs to the TPP enzyme family
B9S66_RS26510	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS26525	COG1802	Transcriptional regulator
B9S66_RS26535	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B9S66_RS26540	COG3835	regulator
B9S66_RS26555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B9S66_RS26560	COG2252	PERMEase
B9S66_RS26600	COG1309	transcriptional regulator
B9S66_RS26610	COG2197	response regulator
B9S66_RS26615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B9S66_RS26620	COG0318	PFAM AMP-dependent synthetase and ligase
B9S66_RS26630	COG3960	tartronate-semialdehyde synthase activity
B9S66_RS26640	COG0753	catalase activity
B9S66_RS26645	COG2084	Dehydrogenase
B9S66_RS26650	COG3622	Belongs to the hyi family
B9S66_RS26670	COG2351	hydroxyisourate hydrolase activity
B9S66_RS26685	COG2233	PERMEase
B9S66_RS26735	COG1609	Transcriptional regulator
B9S66_RS26755	COG1621	beta-fructofuranosidase activity
B9S66_RS26760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B9S66_RS26765	COG3795	YCII-related domain
B9S66_RS26770	COG4941	Belongs to the sigma-70 factor family
B9S66_RS26785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B9S66_RS26790	COG2080	2 iron, 2 sulfur cluster binding
B9S66_RS26795	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B9S66_RS26800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B9S66_RS26815	COG1414	Transcriptional regulator
B9S66_RS26820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B9S66_RS26835	COG4585	Histidine kinase
B9S66_RS26840	COG2197	response regulator
B9S66_RS26855	COG0673	inositol 2-dehydrogenase activity
B9S66_RS26860	COG2188	Transcriptional regulator
B9S66_RS26870	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS26880	COG1940	carbohydrate kinase activity
B9S66_RS26890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B9S66_RS26970	COG0464	growth
B9S66_RS26980	COG2197	response regulator
B9S66_RS27010	COG2207	Transcriptional regulator
B9S66_RS27015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B9S66_RS27020	COG2375	cellular response to nickel ion
B9S66_RS27025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS27030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS27035	COG1120	ATPase activity
B9S66_RS27040	COG1132	(ABC) transporter
B9S66_RS27045	COG1132	(ABC) transporter
B9S66_RS27050	COG2133	pyrroloquinoline quinone binding
B9S66_RS27050	COG5183	chlorophyll binding
B9S66_RS27080	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS27095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B9S66_RS27130	COG1126	abc transporter atp-binding protein
B9S66_RS27135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9S66_RS27140	COG0765	amino acid transport
B9S66_RS27145	COG0765	amino acid transport
B9S66_RS27175	COG0405	Gamma-glutamyltransferase
B9S66_RS27200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B9S66_RS27220	COG0095	Lipoate-protein ligase
B9S66_RS27230	COG0483	inositol monophosphate 1-phosphatase activity
B9S66_RS27245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B9S66_RS27260	COG0159	tryptophan synthase activity
B9S66_RS27285	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B9S66_RS27295	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS27300	COG0702	epimerase
B9S66_RS27305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B9S66_RS27320	COG0488	(ABC) transporter
B9S66_RS27325	COG1929	Belongs to the glycerate kinase type-1 family
B9S66_RS27335	COG0688	phosphatidylethanolamine metabolic process
B9S66_RS27350	COG2301	Belongs to the HpcH HpaI aldolase family
B9S66_RS27355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9S66_RS27355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9S66_RS27360	COG0604	alcohol dehydrogenase
B9S66_RS27370	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9S66_RS27375	COG1120	ATPase activity
B9S66_RS27380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS27385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9S66_RS27430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B9S66_RS27440	COG1619	proteins homologs of microcin C7 resistance protein MccF
B9S66_RS27460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B9S66_RS27485	COG3226	Transcriptional regulator
B9S66_RS27500	COG4106	trans-aconitate 2-methyltransferase activity
B9S66_RS27505	COG1597	lipid kinase activity
B9S66_RS27515	COG0693	protein deglycase activity
B9S66_RS27575	COG1140	nitrate reductase beta subunit
B9S66_RS27605	COG2154	pterin-4-alpha-carbinolamine dehydratase
B9S66_RS27620	COG2826	transposase and inactivated derivatives, IS30 family
B9S66_RS27635	COG1115	amino acid carrier protein
B9S66_RS27640	COG0583	DNA-binding transcription factor activity
B9S66_RS27650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B9S66_RS27660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B9S66_RS27665	COG1940	carbohydrate kinase activity
B9S66_RS27670	COG1129	ABC transporter
B9S66_RS27675	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS27685	COG0673	inositol 2-dehydrogenase activity
B9S66_RS27750	COG1295	ribonuclease BN
B9S66_RS27770	COG1609	Transcriptional regulator
B9S66_RS27775	COG1129	ABC transporter
B9S66_RS27780	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS27785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9S66_RS27790	COG1869	D-ribose catabolic process
B9S66_RS27800	COG2259	Doxx family
B9S66_RS27805	COG2814	Major facilitator Superfamily
B9S66_RS27825	COG1012	belongs to the aldehyde dehydrogenase family
B9S66_RS27885	COG1846	Transcriptional regulator
B9S66_RS27890	COG2274	protein secretion by the type I secretion system
B9S66_RS27930	COG0789	Transcriptional regulator
B9S66_RS27965	COG1024	Enoyl-CoA hydratase
B9S66_RS27970	COG1793	dna ligase
B9S66_RS27980	COG0254	rRNA binding
B9S66_RS28035	COG0488	(ABC) transporter
B9S66_RS28045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B9S66_RS28045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B9S66_RS28085	COG1515	deoxyribonuclease V activity
B9S66_RS28090	COG1683	Conserved Protein
B9S66_RS28095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B9S66_RS28105	COG0183	Belongs to the thiolase family
B9S66_RS28110	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9S66_RS28110	COG1024	Enoyl-CoA hydratase
B9S66_RS28115	COG0789	Transcriptional regulator
B9S66_RS28120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9S66_RS28140	COG2226	methyltransferase
B9S66_RS28145	COG0402	S-adenosylhomocysteine deaminase activity
B9S66_RS28150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B9S66_RS28155	COG1802	Transcriptional regulator
B9S66_RS28170	COG2183	response to ionizing radiation
B9S66_RS28190	COG1024	Enoyl-CoA hydratase
B9S66_RS28205	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B9S66_RS28220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B9S66_RS28245	COG1134	teichoic acid transport
B9S66_RS28245	COG1388	LysM domain
B9S66_RS28250	COG1562	ergosterol biosynthetic process
B9S66_RS28260	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B9S66_RS28270	COG1657	PFAM Prenyltransferase squalene oxidase
B9S66_RS28300	COG2365	Tyrosine phosphatase family
B9S66_RS28305	COG2755	lipolytic protein G-D-S-L family
B9S66_RS28375	COG3958	Transketolase
B9S66_RS28380	COG3959	Transketolase, thiamine diphosphate binding domain
B9S66_RS28400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9S66_RS28405	COG4521	taurine ABC transporter
B9S66_RS28440	COG0740	serine-type endopeptidase activity
B9S66_RS28445	COG0740	serine-type endopeptidase activity
B9S66_RS28490	COG2391	methyltransferase activity
B9S66_RS28495	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS28500	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9S66_RS28505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B9S66_RS28510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B9S66_RS28515	COG0583	DNA-binding transcription factor activity
B9S66_RS28520	COG0183	Belongs to the thiolase family
B9S66_RS28525	COG0477	Major facilitator Superfamily
B9S66_RS28595	COG1233	COG1233 Phytoene dehydrogenase and related
B9S66_RS28600	COG2130	NADP-dependent
B9S66_RS28605	COG2124	cytochrome p450
B9S66_RS28640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B9S66_RS28685	COG2018	Roadblock/LC7 domain
B9S66_RS28700	COG1946	Acyl-CoA thioesterase
B9S66_RS28715	COG1132	(ABC) transporter
B9S66_RS28720	COG1132	(ABC) transporter
B9S66_RS28740	COG1132	(ABC) transporter
B9S66_RS28745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B9S66_RS28750	COG0492	ferredoxin-NADP+ reductase activity
B9S66_RS28755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9S66_RS28765	COG1116	anion transmembrane transporter activity
B9S66_RS28770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9S66_RS28775	COG0432	Pfam Uncharacterised protein family UPF0047
B9S66_RS28780	COG1609	Transcriptional regulator
B9S66_RS28790	COG1175	transmembrane transport
B9S66_RS28800	COG1472	Belongs to the glycosyl hydrolase 3 family
B9S66_RS28810	COG1309	transcriptional regulator
B9S66_RS28815	COG0477	Major facilitator Superfamily
B9S66_RS28845	COG2814	Major facilitator Superfamily
B9S66_RS28850	COG2207	Transcriptional regulator
B9S66_RS28855	COG1120	ATPase activity
B9S66_RS28860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B9S66_RS28880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B9S66_RS28905	COG0583	DNA-binding transcription factor activity
B9S66_RS28925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B9S66_RS28930	COG0303	'Molybdopterin
B9S66_RS28945	COG0243	molybdopterin cofactor binding
B9S66_RS28950	COG0076	glutamate decarboxylase activity
B9S66_RS28960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B9S66_RS28970	COG2706	6-phosphogluconolactonase activity
B9S66_RS28985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B9S66_RS29000	COG1902	pentaerythritol trinitrate reductase activity
B9S66_RS29005	COG0640	Transcriptional regulator
B9S66_RS29010	COG2233	PERMEase
B9S66_RS29040	COG0671	phosphoesterase, PA-phosphatase related
B9S66_RS29060	COG1846	Transcriptional regulator
B9S66_RS29075	COG0584	glycerophosphoryl diester phosphodiesterase
B9S66_RS29115	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B9S66_RS29140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B9S66_RS29170	COG2223	nitrite transmembrane transporter activity
B9S66_RS29180	COG1940	carbohydrate kinase activity
B9S66_RS29200	COG1349	DNA-binding transcription factor activity
B9S66_RS29220	COG0633	Ferredoxin
B9S66_RS29220	COG3217	Mosc domain protein beta barrel domain protein
B9S66_RS29235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B9S66_RS29245	COG0513	Belongs to the DEAD box helicase family
B9S66_RS29260	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS29290	COG1695	Transcriptional regulator
B9S66_RS29300	COG2226	methyltransferase
B9S66_RS29320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B9S66_RS29345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B9S66_RS29350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B9S66_RS29350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B9S66_RS29355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B9S66_RS29355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B9S66_RS29355	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B9S66_RS29365	COG1349	DNA-binding transcription factor activity
B9S66_RS29380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B9S66_RS29390	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9S66_RS29400	COG1960	acyl-CoA dehydrogenase activity
B9S66_RS29410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B9S66_RS29430	COG1120	ATPase activity
B9S66_RS29445	COG0640	Transcriptional regulator
B9S66_RS29450	COG0346	lactoylglutathione lyase activity
B9S66_RS29460	COG0702	epimerase
B9S66_RS29480	COG0326	Molecular chaperone. Has ATPase activity
B9S66_RS29500	COG1131	(ABC) transporter
B9S66_RS29505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B9S66_RS29510	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS29540	COG0667	Aldo Keto reductase
B9S66_RS29565	COG1595	DNA-templated transcription, initiation
B9S66_RS29595	COG0431	NADPH-dependent FMN reductase
B9S66_RS29600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9S66_RS29605	COG0328	RNA-DNA hybrid ribonuclease activity
B9S66_RS29620	COG0477	Major facilitator Superfamily
B9S66_RS29645	COG3268	Saccharopine dehydrogenase
B9S66_RS29660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B9S66_RS29675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B9S66_RS29690	COG2197	response regulator
B9S66_RS29710	COG0475	glutathione-regulated potassium exporter activity
B9S66_RS29745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B9S66_RS29755	COG0446	pyridine nucleotide-disulphide oxidoreductase
B9S66_RS29755	COG1902	pentaerythritol trinitrate reductase activity
B9S66_RS29775	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9S66_RS29785	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B9S66_RS29795	COG0713	ATP synthesis coupled electron transport
B9S66_RS29800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B9S66_RS29805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9S66_RS29810	COG1007	ATP synthesis coupled electron transport
B9S66_RS29830	COG2267	carboxylic ester hydrolase activity
B9S66_RS29845	COG2084	Dehydrogenase
B9S66_RS29895	COG2356	endonuclease I
B9S66_RS29905	COG2813	Specifically methylates the guanine in position
B9S66_RS29910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B9S66_RS29915	COG0589	response to stress
B9S66_RS29920	COG0318	PFAM AMP-dependent synthetase and ligase
B9S66_RS29980	COG0277	FAD linked oxidase domain protein
B9S66_RS30015	COG1793	dna ligase
B9S66_RS30040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B9S66_RS30050	COG0747	negative chemotaxis
B9S66_RS30055	COG0601	transmembrane transport
B9S66_RS30060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9S66_RS30065	COG0444	Belongs to the ABC transporter superfamily
B9S66_RS30070	COG4608	Belongs to the ABC transporter superfamily
B9S66_RS30120	COG0446	pyridine nucleotide-disulphide oxidoreductase
B9S66_RS30120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B9S66_RS30195	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
B9S66_RS30200	COG4585	Histidine kinase
B9S66_RS30205	COG2197	response regulator
B9S66_RS30215	COG2080	2 iron, 2 sulfur cluster binding
B9S66_RS30220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B9S66_RS30225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B9S66_RS30250	COG0477	Major facilitator Superfamily
B9S66_RS30255	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS30275	COG1175	transmembrane transport
B9S66_RS30280	COG0395	ABC-type sugar transport system, permease component
B9S66_RS30285	COG1609	Transcriptional regulator
B9S66_RS30290	COG1874	Beta-galactosidase
B9S66_RS30295	COG1472	Belongs to the glycosyl hydrolase 3 family
B9S66_RS30315	COG4977	sequence-specific DNA binding
B9S66_RS30320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B9S66_RS30355	COG1063	alcohol dehydrogenase
B9S66_RS30370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B9S66_RS30405	COG1879	ABC-type sugar transport system periplasmic component
B9S66_RS30410	COG1129	ABC transporter
B9S66_RS30415	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9S66_RS30420	COG1063	alcohol dehydrogenase
B9S66_RS30430	COG2186	Transcriptional regulator
B9S66_RS30435	COG4948	Mandelate Racemase Muconate Lactonizing
B9S66_RS30440	COG0800	Aldolase
B9S66_RS30445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9S66_RS30450	COG3386	PFAM SMP-30 Gluconolaconase
B9S66_RS30480	COG1136	(ABC) transporter
B9S66_RS30490	COG0577	efflux transmembrane transporter activity
B9S66_RS30495	COG0745	RESPONSE REGULATOR receiver
B9S66_RS30500	COG2205	protein histidine kinase activity
B9S66_RS30600	COG2197	response regulator
B9S66_RS30605	COG4585	Histidine kinase
B9S66_RS30625	COG1136	(ABC) transporter
B9S66_RS30625	COG4591	ABC-type transport system involved in lipoprotein release permease component
B9S66_RS30710	COG1959	2 iron, 2 sulfur cluster binding
B9S66_RS30715	COG1028	Short-chain dehydrogenase reductase Sdr
B9S66_RS30740	COG1192	Involved in chromosome partitioning
B9S66_RS30840	COG0640	Transcriptional regulator
B9S66_RS30985	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B9S66_RS30995	COG2205	protein histidine kinase activity
B9S66_RS31090	COG1857	crispr-associated protein
B9S66_RS31105	COG1518	maintenance of DNA repeat elements
B9S66_RS31110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B9S66_RS31120	COG0305	Participates in initiation and elongation during chromosome replication
B9S66_RS31225	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B9S66_RS31350	COG1051	belongs to the nudix hydrolase family
B9S66_RS31435	COG1051	belongs to the nudix hydrolase family