locus-tag	class	description
RVR_RS00085	COG0745	RESPONSE REGULATOR receiver
RVR_RS00105	COG3250	beta-galactosidase activity
RVR_RS00120	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS00160	COG0789	Transcriptional regulator
RVR_RS00175	COG1609	Transcriptional regulator
RVR_RS00185	COG0395	ABC-type sugar transport system, permease component
RVR_RS00195	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RVR_RS00210	COG1891	lyase activity
RVR_RS00215	COG1309	transcriptional regulator
RVR_RS00230	COG0583	DNA-binding transcription factor activity
RVR_RS00235	COG0156	8-amino-7-oxononanoate synthase activity
RVR_RS00240	COG1063	alcohol dehydrogenase
RVR_RS00245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RVR_RS00260	COG3537	Alpha-1,2-mannosidase
RVR_RS00280	COG1063	alcohol dehydrogenase
RVR_RS00305	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS00315	COG2814	Major facilitator Superfamily
RVR_RS00320	COG1309	transcriptional regulator
RVR_RS00325	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
RVR_RS00370	COG2770	Histidine kinase
RVR_RS00370	COG2208	phosphoserine phosphatase activity
RVR_RS00375	COG0328	RNA-DNA hybrid ribonuclease activity
RVR_RS00390	COG3547	Transposase (IS116 IS110 IS902 family)
RVR_RS00395	COG1846	Transcriptional regulator
RVR_RS00430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RVR_RS00430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RVR_RS00440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RVR_RS00445	COG2197	response regulator
RVR_RS00450	COG4585	Histidine kinase
RVR_RS00460	COG1131	(ABC) transporter
RVR_RS00470	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RVR_RS00475	COG2890	protein-(glutamine-N5) methyltransferase activity
RVR_RS00480	COG3250	beta-galactosidase activity
RVR_RS00495	COG0714	Associated with various cellular activities
RVR_RS00510	COG2066	Belongs to the glutaminase family
RVR_RS00510	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
RVR_RS00545	COG0745	RESPONSE REGULATOR receiver
RVR_RS00560	COG1960	acyl-CoA dehydrogenase activity
RVR_RS00575	COG3442	glutamine amidotransferase
RVR_RS00580	COG0205	6-phosphofructokinase activity
RVR_RS00600	COG0477	Major facilitator Superfamily
RVR_RS00620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RVR_RS00625	COG0829	nickel cation binding
RVR_RS00630	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RVR_RS00635	COG0830	nickel cation binding
RVR_RS00640	COG0804	urea catabolic process
RVR_RS00645	COG0832	Belongs to the urease beta subunit family
RVR_RS00650	COG0831	urea catabolic process
RVR_RS00660	COG0740	serine-type endopeptidase activity
RVR_RS00670	COG1388	LysM domain
RVR_RS00670	COG0791	NLP P60 protein
RVR_RS00680	COG1131	(ABC) transporter
RVR_RS00690	COG0701	Predicted permease
RVR_RS00715	COG0156	8-amino-7-oxononanoate synthase activity
RVR_RS00720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RVR_RS00725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RVR_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS00740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RVR_RS00770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RVR_RS00785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RVR_RS00800	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS00805	COG1940	carbohydrate kinase activity
RVR_RS00810	COG2188	Transcriptional regulator
RVR_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS00820	COG2252	PERMEase
RVR_RS00840	COG0419	ATPase involved in DNA repair
RVR_RS00845	COG0420	3'-5' exonuclease activity
RVR_RS00850	COG1739	Uncharacterized protein family UPF0029
RVR_RS00855	COG1832	CoA-binding protein
RVR_RS00865	COG0110	maltose O-acetyltransferase activity
RVR_RS00900	COG2814	Major facilitator Superfamily
RVR_RS00910	COG1959	2 iron, 2 sulfur cluster binding
RVR_RS00915	COG0667	Aldo Keto reductase
RVR_RS00930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RVR_RS00935	COG0583	DNA-binding transcription factor activity
RVR_RS00955	COG1295	ribonuclease BN
RVR_RS01025	COG2890	protein-(glutamine-N5) methyltransferase activity
RVR_RS01030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RVR_RS01035	COG1982	Orn Lys Arg decarboxylase major
RVR_RS01045	COG1366	Belongs to the anti-sigma-factor antagonist family
RVR_RS01060	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RVR_RS01080	COG0142	geranyltranstransferase activity
RVR_RS01085	COG0783	Belongs to the Dps family
RVR_RS01090	COG0596	Alpha beta hydrolase
RVR_RS01110	COG1191	sigma factor activity
RVR_RS01190	COG2124	cytochrome p450
RVR_RS01205	COG1132	(ABC) transporter
RVR_RS01235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RVR_RS01240	COG0174	glutamine synthetase
RVR_RS01260	COG0596	Alpha beta hydrolase
RVR_RS01305	COG0765	amino acid transport
RVR_RS01310	COG1126	abc transporter atp-binding protein
RVR_RS01315	COG2843	Capsule synthesis protein
RVR_RS01325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RVR_RS01330	COG0277	FAD linked oxidase domain protein
RVR_RS01400	COG2197	response regulator
RVR_RS01410	COG2382	esterase
RVR_RS01420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RVR_RS01495	COG0437	4 iron, 4 sulfur cluster binding
RVR_RS01500	COG3383	formate dehydrogenase (NAD+) activity
RVR_RS01500	COG0243	molybdopterin cofactor binding
RVR_RS01515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RVR_RS01520	COG0028	Belongs to the TPP enzyme family
RVR_RS01530	COG3842	ATPase activity
RVR_RS01545	COG2843	Capsule synthesis protein
RVR_RS01560	COG0300	oxidoreductase activity
RVR_RS01565	COG0789	Transcriptional regulator
RVR_RS01635	COG1006	Multisubunit Na H antiporter MnhC subunit
RVR_RS01640	COG0651	ATP synthesis coupled electron transport
RVR_RS01655	COG2890	protein-(glutamine-N5) methyltransferase activity
RVR_RS01660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS01675	COG1335	isochorismatase
RVR_RS01680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RVR_RS01690	COG0028	Belongs to the TPP enzyme family
RVR_RS01705	COG2770	Histidine kinase
RVR_RS01705	COG2208	phosphoserine phosphatase activity
RVR_RS01775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RVR_RS01790	COG4555	ABC transporter
RVR_RS01805	COG0312	modulator of DNA gyrase
RVR_RS01825	COG1940	carbohydrate kinase activity
RVR_RS01835	COG2382	esterase
RVR_RS01835	COG3693	PFAM glycoside hydrolase, family 10
RVR_RS01835	COG3507	Belongs to the glycosyl hydrolase 43 family
RVR_RS01875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RVR_RS01900	COG1012	belongs to the aldehyde dehydrogenase family
RVR_RS01945	COG0517	IMP dehydrogenase activity
RVR_RS01945	COG0516	GMP reductase activity
RVR_RS01950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RVR_RS01975	COG3119	arylsulfatase activity
RVR_RS02010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RVR_RS02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RVR_RS02055	COG3285	dna ligase
RVR_RS02055	COG1793	dna ligase
RVR_RS02060	COG0693	protein deglycase activity
RVR_RS02080	COG3458	cephalosporin-C deacetylase activity
RVR_RS02085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RVR_RS02095	COG0393	Putative heavy-metal-binding
RVR_RS02105	COG3940	Belongs to the glycosyl hydrolase 43 family
RVR_RS02125	COG1846	Transcriptional regulator
RVR_RS02135	COG2936	dipeptidyl-peptidase activity
RVR_RS02150	COG1175	transmembrane transport
RVR_RS02155	COG0395	ABC-type sugar transport system, permease component
RVR_RS02160	COG1501	Belongs to the glycosyl hydrolase 31 family
RVR_RS02165	COG1609	Transcriptional regulator
RVR_RS02170	COG0738	Major facilitator superfamily
RVR_RS02190	COG0745	RESPONSE REGULATOR receiver
RVR_RS02195	COG2205	protein histidine kinase activity
RVR_RS02200	COG2135	peptidase activity
RVR_RS02205	COG2205	protein histidine kinase activity
RVR_RS02210	COG0745	RESPONSE REGULATOR receiver
RVR_RS02220	COG2226	methyltransferase
RVR_RS02235	COG0659	secondary active sulfate transmembrane transporter activity
RVR_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS02265	COG1609	Transcriptional regulator
RVR_RS02275	COG1609	Transcriptional regulator
RVR_RS02295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RVR_RS02300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RVR_RS02310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RVR_RS02320	COG0477	Major facilitator Superfamily
RVR_RS02330	COG1609	Transcriptional regulator
RVR_RS02360	COG3345	alpha-galactosidase
RVR_RS02375	COG5280	Phage tail tape measure protein TP901
RVR_RS02375	COG3953	SLT domain
RVR_RS02410	COG1175	transmembrane transport
RVR_RS02445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RVR_RS02450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RVR_RS02465	COG3347	Dehydrogenase
RVR_RS02465	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS02470	COG1070	Carbohydrate kinase
RVR_RS02475	COG0247	lactate metabolic process
RVR_RS02480	COG1139	Iron-sulfur cluster binding protein
RVR_RS02485	COG1556	Lactate utilization protein
RVR_RS02490	COG1609	Transcriptional regulator
RVR_RS02520	COG0582	viral genome integration into host DNA
RVR_RS02565	COG1309	transcriptional regulator
RVR_RS02605	COG4257	antibiotic catabolic process
RVR_RS02620	COG1879	ABC-type sugar transport system periplasmic component
RVR_RS02625	COG1129	ABC transporter
RVR_RS02630	COG1172	Belongs to the binding-protein-dependent transport system permease family
RVR_RS02640	COG1609	Transcriptional regulator
RVR_RS02685	COG1725	Transcriptional regulator
RVR_RS02700	COG0667	Aldo Keto reductase
RVR_RS02715	COG1063	alcohol dehydrogenase
RVR_RS02760	COG0583	DNA-binding transcription factor activity
RVR_RS02765	COG2814	Major facilitator Superfamily
RVR_RS02770	COG0490	domain, Protein
RVR_RS02775	COG0475	glutathione-regulated potassium exporter activity
RVR_RS02780	COG2837	iron assimilation
RVR_RS02805	COG2315	Protein conserved in bacteria
RVR_RS02815	COG2172	sigma factor antagonist activity
RVR_RS02815	COG2208	phosphoserine phosphatase activity
RVR_RS02815	COG1366	Belongs to the anti-sigma-factor antagonist family
RVR_RS02825	COG1175	transmembrane transport
RVR_RS02835	COG1472	Belongs to the glycosyl hydrolase 3 family
RVR_RS02855	COG0583	DNA-binding transcription factor activity
RVR_RS02870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RVR_RS02880	COG2186	Transcriptional regulator
RVR_RS02885	COG1609	Transcriptional regulator
RVR_RS02920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RVR_RS02925	COG1012	belongs to the aldehyde dehydrogenase family
RVR_RS02935	COG3511	phospholipase C
RVR_RS02940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RVR_RS02945	COG1053	succinate dehydrogenase
RVR_RS02980	COG2207	Transcriptional regulator
RVR_RS02985	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS03000	COG3511	phospholipase C
RVR_RS03025	COG0477	Major facilitator Superfamily
RVR_RS03030	COG1309	transcriptional regulator
RVR_RS03060	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS03080	COG0656	L-ascorbic acid biosynthetic process
RVR_RS03090	COG1404	Belongs to the peptidase S8 family
RVR_RS03115	COG3629	intracellular signal transduction
RVR_RS03115	COG3903	Transcriptional regulator
RVR_RS03130	COG0515	serine threonine protein kinase
RVR_RS03145	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RVR_RS03150	COG0297	glycogen (starch) synthase activity
RVR_RS03160	COG3458	cephalosporin-C deacetylase activity
RVR_RS03165	COG1191	sigma factor activity
RVR_RS03170	COG2814	Major facilitator Superfamily
RVR_RS03175	COG1472	Belongs to the glycosyl hydrolase 3 family
RVR_RS03185	COG2822	iron ion transport
RVR_RS03235	COG1793	dna ligase
RVR_RS03250	COG3012	SEC-C Motif Domain Protein
RVR_RS03260	COG0477	Major facilitator Superfamily
RVR_RS03280	COG1132	(ABC) transporter
RVR_RS03300	COG2814	Major facilitator Superfamily
RVR_RS03360	COG0508	dehydrogenase complex catalyzes the overall conversion of
RVR_RS03360	COG0596	Alpha beta hydrolase
RVR_RS03375	COG1012	belongs to the aldehyde dehydrogenase family
RVR_RS03410	COG1940	carbohydrate kinase activity
RVR_RS03415	COG0673	inositol 2-dehydrogenase activity
RVR_RS03420	COG1082	Xylose isomerase domain protein TIM barrel
RVR_RS03430	COG0673	inositol 2-dehydrogenase activity
RVR_RS03435	COG1968	undecaprenyl-diphosphatase activity
RVR_RS03440	COG3979	chitinase
RVR_RS03465	COG0667	Aldo Keto reductase
RVR_RS03470	COG0671	phosphoesterase, PA-phosphatase related
RVR_RS03480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS03485	COG1686	Belongs to the peptidase S11 family
RVR_RS03495	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RVR_RS03505	COG0739	heme binding
RVR_RS03530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RVR_RS03535	COG2364	Membrane
RVR_RS03550	COG1216	Glycosyl transferase, family 2
RVR_RS03565	COG1522	sequence-specific DNA binding
RVR_RS03570	COG0277	FAD linked oxidase domain protein
RVR_RS03580	COG1960	acyl-CoA dehydrogenase activity
RVR_RS03585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RVR_RS03585	COG0515	serine threonine protein kinase
RVR_RS03590	COG5001	Diguanylate cyclase
RVR_RS03590	COG3300	MHYT domain
RVR_RS03600	COG3469	chitinase activity
RVR_RS03640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RVR_RS03645	COG0140	phosphoribosyl-ATP diphosphatase activity
RVR_RS03650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RVR_RS03655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RVR_RS03655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RVR_RS03660	COG3201	nicotinamide mononucleotide transporter
RVR_RS03690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RVR_RS03720	COG2390	Transcriptional regulator
RVR_RS03725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RVR_RS03730	COG3345	alpha-galactosidase
RVR_RS03740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RVR_RS03745	COG0242	peptide deformylase activity
RVR_RS03760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RVR_RS03770	COG1758	RNA polymerase activity
RVR_RS03785	COG0284	orotidine-5'-phosphate decarboxylase activity
RVR_RS03790	COG0167	dihydroorotate dehydrogenase activity
RVR_RS03795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RVR_RS03800	COG0505	Belongs to the CarA family
RVR_RS03810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RVR_RS03815	COG0540	Belongs to the ATCase OTCase family
RVR_RS03820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RVR_RS03845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RVR_RS03850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RVR_RS03855	COG0006	proline dipeptidase activity
RVR_RS03875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RVR_RS03880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RVR_RS03885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RVR_RS03890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RVR_RS03895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RVR_RS03900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RVR_RS03905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RVR_RS03910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RVR_RS03930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RVR_RS03950	COG0124	histidyl-tRNA synthetase
RVR_RS03960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RVR_RS03965	COG1196	nuclear chromosome segregation
RVR_RS03970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RVR_RS03980	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RVR_RS03985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RVR_RS03995	COG2255	four-way junction helicase activity
RVR_RS04000	COG0632	four-way junction helicase activity
RVR_RS04005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RVR_RS04010	COG0217	transcriptional regulatory protein
RVR_RS04015	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RVR_RS04020	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
RVR_RS04030	COG0438	transferase activity, transferring glycosyl groups
RVR_RS04035	COG1560	Kdo2-lipid A biosynthetic process
RVR_RS04040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RVR_RS04065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RVR_RS04085	COG3547	Transposase (IS116 IS110 IS902 family)
RVR_RS04095	COG1733	regulation of RNA biosynthetic process
RVR_RS04200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RVR_RS04235	COG1960	acyl-CoA dehydrogenase activity
RVR_RS04240	COG1960	acyl-CoA dehydrogenase activity
RVR_RS04250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RVR_RS04255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RVR_RS04255	COG1648	precorrin-2 dehydrogenase activity
RVR_RS04260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RVR_RS04275	COG2226	methyltransferase
RVR_RS04295	COG0204	Acyl-transferase
RVR_RS04295	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS04300	COG0165	Argininosuccinate lyase
RVR_RS04305	COG1438	arginine binding
RVR_RS04310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RVR_RS04320	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RVR_RS04325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RVR_RS04330	COG2838	Isocitrate dehydrogenase
RVR_RS04335	COG2813	Specifically methylates the guanine in position
RVR_RS04355	COG1649	PFAM Uncharacterised BCR, COG1649
RVR_RS04370	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RVR_RS04375	COG2188	Transcriptional regulator
RVR_RS04440	COG2274	protein secretion by the type I secretion system
RVR_RS04495	COG0667	Aldo Keto reductase
RVR_RS04500	COG1414	Transcriptional regulator
RVR_RS04515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RVR_RS04520	COG1388	LysM domain
RVR_RS04520	COG1134	teichoic acid transport
RVR_RS04525	COG0072	phenylalanine-tRNA ligase activity
RVR_RS04525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RVR_RS04530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RVR_RS04535	COG5002	protein histidine kinase activity
RVR_RS04540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RVR_RS04545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RVR_RS04550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RVR_RS04555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RVR_RS04565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RVR_RS04600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RVR_RS04615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RVR_RS04645	COG3959	Transketolase, thiamine diphosphate binding domain
RVR_RS04685	COG0805	protein transport
RVR_RS04690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RVR_RS04705	COG2378	regulation of single-species biofilm formation
RVR_RS04725	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
RVR_RS04735	COG1609	Transcriptional regulator
RVR_RS04740	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
RVR_RS04745	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
RVR_RS04755	COG4122	O-methyltransferase activity
RVR_RS04760	COG1222	aaa ATPase
RVR_RS04780	COG0517	IMP dehydrogenase activity
RVR_RS04780	COG1994	Peptidase M50
RVR_RS04790	COG2197	response regulator
RVR_RS04795	COG4166	transmembrane transport
RVR_RS04800	COG0546	phosphoglycolate phosphatase activity
RVR_RS04805	COG1410	methionine synthase
RVR_RS04805	COG0646	methionine synthase
RVR_RS04810	COG1414	Transcriptional regulator
RVR_RS04815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RVR_RS04820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RVR_RS04825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RVR_RS04835	COG2186	Transcriptional regulator
RVR_RS04855	COG4948	Mandelate Racemase Muconate Lactonizing
RVR_RS04865	COG0215	cysteine-tRNA ligase activity
RVR_RS04890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS04895	COG0667	Aldo Keto reductase
RVR_RS04925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RVR_RS04945	COG2850	peptidyl-arginine hydroxylation
RVR_RS04975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RVR_RS04985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS04990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RVR_RS04995	COG2208	phosphoserine phosphatase activity
RVR_RS04995	COG2172	sigma factor antagonist activity
RVR_RS04995	COG1366	Belongs to the anti-sigma-factor antagonist family
RVR_RS05010	COG1309	transcriptional regulator
RVR_RS05015	COG0477	Major facilitator Superfamily
RVR_RS05020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RVR_RS05040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS05055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS05065	COG1126	abc transporter atp-binding protein
RVR_RS05080	COG0179	Fumarylacetoacetate (FAA) hydrolase
RVR_RS05100	COG0395	ABC-type sugar transport system, permease component
RVR_RS05105	COG1175	transmembrane transport
RVR_RS05125	COG1414	Transcriptional regulator
RVR_RS05130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RVR_RS05135	COG4948	Mandelate Racemase Muconate Lactonizing
RVR_RS05140	COG0418	dihydroorotase activity
RVR_RS05145	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS05170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RVR_RS05180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RVR_RS05200	COG3340	Belongs to the peptidase S51 family
RVR_RS05215	COG1940	carbohydrate kinase activity
RVR_RS05230	COG3833	ABC-type maltose transport systems, permease component
RVR_RS05265	COG0395	ABC-type sugar transport system, permease component
RVR_RS05270	COG4209	transmembrane transport
RVR_RS05275	COG1653	transport
RVR_RS05285	COG1233	COG1233 Phytoene dehydrogenase and related
RVR_RS05295	COG0583	DNA-binding transcription factor activity
RVR_RS05310	COG0531	amino acid
RVR_RS05325	COG0477	Major facilitator Superfamily
RVR_RS05340	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RVR_RS05345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RVR_RS05350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RVR_RS05355	COG1120	ATPase activity
RVR_RS05360	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RVR_RS05370	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RVR_RS05375	COG0697	spore germination
RVR_RS05380	COG1846	Transcriptional regulator
RVR_RS05390	COG1609	Transcriptional regulator
RVR_RS05400	COG0640	Transcriptional regulator
RVR_RS05405	COG0798	PFAM Bile acid sodium symporter
RVR_RS05435	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RVR_RS05490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RVR_RS05500	COG3540	Alkaline phosphatase
RVR_RS05510	COG2154	pterin-4-alpha-carbinolamine dehydratase
RVR_RS05540	COG0477	Major facilitator Superfamily
RVR_RS05620	COG3547	Transposase (IS116 IS110 IS902 family)
RVR_RS05625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RVR_RS05630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RVR_RS05640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RVR_RS05645	COG0583	DNA-binding transcription factor activity
RVR_RS05655	COG3971	2-oxopent-4-enoate hydratase activity
RVR_RS05660	COG2186	Transcriptional regulator
RVR_RS05720	COG2409	Drug exporters of the RND superfamily
RVR_RS05745	COG2409	Drug exporters of the RND superfamily
RVR_RS05750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RVR_RS05765	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RVR_RS05770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RVR_RS05785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RVR_RS05790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RVR_RS05805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RVR_RS05830	COG0529	Catalyzes the synthesis of activated sulfate
RVR_RS05915	COG1595	DNA-templated transcription, initiation
RVR_RS05940	COG0154	amidase activity
RVR_RS05950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RVR_RS05960	COG0745	RESPONSE REGULATOR receiver
RVR_RS05970	COG2226	methyltransferase
RVR_RS05985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RVR_RS05995	COG3485	protocatechuate 3,4-dioxygenase
RVR_RS06000	COG3485	protocatechuate 3,4-dioxygenase
RVR_RS06015	COG4993	Dehydrogenase
RVR_RS06025	COG1414	Transcriptional regulator
RVR_RS06035	COG3420	alginic acid biosynthetic process
RVR_RS06050	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RVR_RS06055	COG1309	transcriptional regulator
RVR_RS06060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RVR_RS06070	COG0508	dehydrogenase complex catalyzes the overall conversion of
RVR_RS06100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS06155	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RVR_RS06165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RVR_RS06165	COG3321	synthase
RVR_RS06170	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS06175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RVR_RS06190	COG3265	gluconokinase activity
RVR_RS06195	COG4948	Mandelate Racemase Muconate Lactonizing
RVR_RS06205	COG1960	acyl-CoA dehydrogenase activity
RVR_RS06215	COG3226	Transcriptional regulator
RVR_RS06220	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS06235	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RVR_RS06240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RVR_RS06260	COG1960	acyl-CoA dehydrogenase activity
RVR_RS06285	COG1309	transcriptional regulator
RVR_RS06290	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RVR_RS06295	COG2188	Transcriptional regulator
RVR_RS06315	COG1725	Transcriptional regulator
RVR_RS06320	COG2226	methyltransferase
RVR_RS06330	COG0142	geranyltranstransferase activity
RVR_RS06335	COG0587	DNA-directed DNA polymerase activity
RVR_RS06340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RVR_RS06345	COG3467	pyridoxamine 5'-phosphate
RVR_RS06360	COG1799	cell septum assembly
RVR_RS06365	COG1960	acyl-CoA dehydrogenase activity
RVR_RS06370	COG0477	Major facilitator Superfamily
RVR_RS06375	COG0671	phosphoesterase, PA-phosphatase related
RVR_RS06400	COG1160	GTP binding
RVR_RS06410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RVR_RS06425	COG3541	Predicted nucleotidyltransferase
RVR_RS06430	COG1187	pseudouridine synthase activity
RVR_RS06435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RVR_RS06440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RVR_RS06455	COG0686	Belongs to the AlaDH PNT family
RVR_RS06465	COG0494	nUDIX hydrolase
RVR_RS06470	COG0504	CTP synthase activity
RVR_RS06475	COG3387	PFAM Glycoside hydrolase 15-related
RVR_RS06480	COG0297	glycogen (starch) synthase activity
RVR_RS06490	COG0497	DNA recombination
RVR_RS06495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RVR_RS06520	COG1120	ATPase activity
RVR_RS06525	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RVR_RS06530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RVR_RS06550	COG0647	UMP catabolic process
RVR_RS06585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RVR_RS06590	COG2094	Belongs to the DNA glycosylase MPG family
RVR_RS06595	COG1881	PFAM PEBP family protein
RVR_RS06620	COG1119	ATPase activity
RVR_RS06635	COG2197	response regulator
RVR_RS06640	COG4585	Histidine kinase
RVR_RS06645	COG4221	oxidoreductase activity
RVR_RS06650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RVR_RS06655	COG3953	SLT domain
RVR_RS06655	COG5412	phage tail tape measure protein
RVR_RS06660	COG1716	ATPase activity
RVR_RS06660	COG1131	(ABC) transporter
RVR_RS06660	COG0842	Transport permease protein
RVR_RS06665	COG3830	Belongs to the UPF0237 family
RVR_RS06665	COG0560	Phosphoserine phosphatase
RVR_RS06690	COG2186	Transcriptional regulator
RVR_RS06695	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RVR_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS06715	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
RVR_RS06720	COG2261	transglycosylase associated protein
RVR_RS06735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RVR_RS06740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RVR_RS06750	COG3387	PFAM Glycoside hydrolase 15-related
RVR_RS06795	COG0488	(ABC) transporter
RVR_RS06815	COG0235	Class ii aldolase
RVR_RS06820	COG0723	plastoquinol--plastocyanin reductase activity
RVR_RS06820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RVR_RS06845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RVR_RS06850	COG1492	cobalamin metabolic process
RVR_RS06865	COG1797	cobyrinic acid a,c-diamide synthase activity
RVR_RS06875	COG0515	serine threonine protein kinase
RVR_RS06875	COG2815	serine threonine protein kinase
RVR_RS06895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RVR_RS06895	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
RVR_RS06900	COG4977	sequence-specific DNA binding
RVR_RS06910	COG3189	MarR family transcriptional regulator
RVR_RS06920	COG1414	Transcriptional regulator
RVR_RS06945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RVR_RS06950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RVR_RS06960	COG1132	(ABC) transporter
RVR_RS06960	COG2375	cellular response to nickel ion
RVR_RS06980	COG3250	beta-galactosidase activity
RVR_RS06990	COG1175	transmembrane transport
RVR_RS06995	COG0395	ABC-type sugar transport system, permease component
RVR_RS07015	COG1349	DNA-binding transcription factor activity
RVR_RS07025	COG0406	alpha-ribazole phosphatase activity
RVR_RS07030	COG2171	N-acyltransferase activity
RVR_RS07035	COG3250	beta-galactosidase activity
RVR_RS07080	COG2151	metal-sulfur cluster biosynthetic enzyme
RVR_RS07085	COG0822	iron-sulfur transferase activity
RVR_RS07090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RVR_RS07095	COG0396	ATPase activity
RVR_RS07105	COG0719	Fe-S assembly protein
RVR_RS07130	COG2814	Major facilitator Superfamily
RVR_RS07140	COG2188	Transcriptional regulator
RVR_RS07165	COG3537	Alpha-1,2-mannosidase
RVR_RS07170	COG0109	protoheme IX farnesyltransferase activity
RVR_RS07180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RVR_RS07195	COG0363	glucosamine-6-phosphate deaminase activity
RVR_RS07200	COG0166	Belongs to the GPI family
RVR_RS07215	COG1737	Transcriptional regulator
RVR_RS07225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RVR_RS07235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RVR_RS07240	COG1481	regulation of sporulation
RVR_RS07245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RVR_RS07250	COG1660	Displays ATPase and GTPase activities
RVR_RS07255	COG0322	excinuclease ABC activity
RVR_RS07265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RVR_RS07295	COG0556	nucleotide-excision repair
RVR_RS07300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RVR_RS07310	COG0237	dephospho-CoA kinase activity
RVR_RS07320	COG0539	negative regulation of cytoplasmic translation
RVR_RS07325	COG2226	methyltransferase
RVR_RS07330	COG1643	Atp-dependent helicase
RVR_RS07350	COG2050	protein possibly involved in aromatic compounds catabolism
RVR_RS07360	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RVR_RS07365	COG0644	oxidoreductase
RVR_RS07370	COG4946	Tricorn protease homolog
RVR_RS07370	COG0793	Belongs to the peptidase S41A family
RVR_RS07380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RVR_RS07385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RVR_RS07390	COG0736	holo-[acyl-carrier-protein] synthase activity
RVR_RS07425	COG1960	acyl-CoA dehydrogenase activity
RVR_RS07435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RVR_RS07460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RVR_RS07485	COG2197	response regulator
RVR_RS07535	COG0737	Belongs to the 5'-nucleotidase family
RVR_RS07565	COG0067	glutamate synthase
RVR_RS07565	COG0070	glutamate synthase
RVR_RS07565	COG0069	glutamate synthase activity
RVR_RS07575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RVR_RS07585	COG0159	tryptophan synthase activity
RVR_RS07590	COG0133	tryptophan synthase activity
RVR_RS07595	COG0134	indole-3-glycerol-phosphate synthase activity
RVR_RS07620	COG1672	PFAM Archaeal ATPase
RVR_RS07620	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RVR_RS07635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RVR_RS07660	COG0107	imidazoleglycerol-phosphate synthase activity
RVR_RS07665	COG0251	oxidation-reduction process
RVR_RS07670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RVR_RS07675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RVR_RS07685	COG0131	Imidazoleglycerol-phosphate dehydratase
RVR_RS07690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RVR_RS07695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RVR_RS07725	COG1432	Conserved Protein
RVR_RS07735	COG0587	DNA-directed DNA polymerase activity
RVR_RS07770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RVR_RS07780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RVR_RS07785	COG3599	regulation of cell shape
RVR_RS07795	COG1799	cell septum assembly
RVR_RS07805	COG1496	oxidoreductase activity
RVR_RS07815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RVR_RS07820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RVR_RS07830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RVR_RS07835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RVR_RS07840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RVR_RS07845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RVR_RS07850	COG0768	penicillin binding
RVR_RS07860	COG0275	rRNA processing
RVR_RS07865	COG2001	Belongs to the MraZ family
RVR_RS07895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RVR_RS07905	COG1309	transcriptional regulator
RVR_RS07910	COG1233	COG1233 Phytoene dehydrogenase and related
RVR_RS07930	COG0352	thiamine-phosphate diphosphorylase activity
RVR_RS07945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RVR_RS07945	COG2022	thiamine diphosphate biosynthetic process
RVR_RS07955	COG2022	thiamine diphosphate biosynthetic process
RVR_RS07960	COG0515	serine threonine protein kinase
RVR_RS07960	COG2815	serine threonine protein kinase
RVR_RS07965	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
RVR_RS07970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RVR_RS07975	COG2193	ferroxidase activity
RVR_RS07980	COG0243	molybdopterin cofactor binding
RVR_RS07985	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RVR_RS08000	COG2197	response regulator
RVR_RS08030	COG1940	carbohydrate kinase activity
RVR_RS08040	COG0003	Pfam Anion-transporting ATPase
RVR_RS08070	COG0438	transferase activity, transferring glycosyl groups
RVR_RS08075	COG0501	Belongs to the peptidase M48B family
RVR_RS08090	COG0791	NLP P60 protein
RVR_RS08105	COG0705	Rhomboid family
RVR_RS08115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RVR_RS08120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RVR_RS08125	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RVR_RS08130	COG0723	plastoquinol--plastocyanin reductase activity
RVR_RS08135	COG2010	Cytochrome c
RVR_RS08140	COG1845	cytochrome c oxidase, subunit III
RVR_RS08150	COG1376	ErfK ybiS ycfS ynhG family protein
RVR_RS08160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RVR_RS08165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RVR_RS08170	COG1104	cysteine desulfurase activity
RVR_RS08175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RVR_RS08195	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RVR_RS08205	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RVR_RS08220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RVR_RS08245	COG4585	Histidine kinase
RVR_RS08250	COG2197	response regulator
RVR_RS08275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RVR_RS08280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RVR_RS08285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RVR_RS08290	COG0508	dehydrogenase complex catalyzes the overall conversion of
RVR_RS08300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RVR_RS08305	COG0456	acetyltransferase
RVR_RS08330	COG0321	lipoyl(octanoyl) transferase activity
RVR_RS08335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RVR_RS08395	COG0702	epimerase
RVR_RS08455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RVR_RS08490	COG0577	efflux transmembrane transporter activity
RVR_RS08490	COG1136	(ABC) transporter
RVR_RS08500	COG1653	transport
RVR_RS08505	COG0366	Alpha amylase catalytic
RVR_RS08515	COG1175	transmembrane transport
RVR_RS08520	COG0395	ABC-type sugar transport system, permease component
RVR_RS08595	COG0765	amino acid transport
RVR_RS08600	COG0765	amino acid transport
RVR_RS08605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RVR_RS08610	COG1126	abc transporter atp-binding protein
RVR_RS08615	COG0583	DNA-binding transcription factor activity
RVR_RS08625	COG1674	ftsk spoiiie
RVR_RS08645	COG0464	growth
RVR_RS08710	COG2963	transposase activity
RVR_RS08725	COG1674	ftsk spoiiie
RVR_RS08730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RVR_RS08755	COG0464	growth
RVR_RS08800	COG4597	amino acid ABC transporter
RVR_RS08855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RVR_RS08865	COG0254	rRNA binding
RVR_RS08870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RVR_RS08875	COG1132	(ABC) transporter
RVR_RS08880	COG1132	(ABC) transporter
RVR_RS08900	COG1063	alcohol dehydrogenase
RVR_RS08910	COG0673	inositol 2-dehydrogenase activity
RVR_RS08940	COG2182	Extracellular solute-binding protein
RVR_RS08945	COG1175	transmembrane transport
RVR_RS08950	COG3833	ABC-type maltose transport systems, permease component
RVR_RS08955	COG0366	Alpha amylase catalytic
RVR_RS08960	COG1609	Transcriptional regulator
RVR_RS08970	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RVR_RS08980	COG1302	Protein conserved in bacteria
RVR_RS08985	COG0174	glutamine synthetase
RVR_RS09040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RVR_RS09080	COG1175	transmembrane transport
RVR_RS09085	COG0395	ABC-type sugar transport system, permease component
RVR_RS09090	COG0366	Alpha amylase catalytic
RVR_RS09095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RVR_RS09095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RVR_RS09100	COG1335	isochorismatase
RVR_RS09105	COG0477	Major facilitator Superfamily
RVR_RS09110	COG1309	transcriptional regulator
RVR_RS09135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RVR_RS09165	COG1994	Peptidase M50
RVR_RS09205	COG5398	heme oxygenase
RVR_RS09230	COG1120	ATPase activity
RVR_RS09235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RVR_RS09240	COG4558	Periplasmic binding protein
RVR_RS09245	COG1834	amidinotransferase
RVR_RS09250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RVR_RS09260	COG0598	Magnesium transport protein CorA
RVR_RS09270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RVR_RS09275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RVR_RS09280	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RVR_RS09315	COG0477	Major facilitator Superfamily
RVR_RS09375	COG1064	alcohol dehydrogenase
RVR_RS09385	COG0489	protein tyrosine kinase activity
RVR_RS09390	COG0297	glycogen (starch) synthase activity
RVR_RS09415	COG0667	Aldo Keto reductase
RVR_RS09425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RVR_RS09435	COG2814	Major facilitator Superfamily
RVR_RS09450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RVR_RS09460	COG3629	intracellular signal transduction
RVR_RS09460	COG3903	Transcriptional regulator
RVR_RS09465	COG3629	intracellular signal transduction
RVR_RS09465	COG3903	Transcriptional regulator
RVR_RS09485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS09505	COG1134	teichoic acid transport
RVR_RS09525	COG1349	DNA-binding transcription factor activity
RVR_RS09540	COG3395	kinase activity
RVR_RS09545	COG0235	Class ii aldolase
RVR_RS09560	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS09660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RVR_RS09665	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS09685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RVR_RS09695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RVR_RS09710	COG2197	response regulator
RVR_RS09715	COG2197	response regulator
RVR_RS09725	COG0604	alcohol dehydrogenase
RVR_RS09730	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RVR_RS09745	COG0583	DNA-binding transcription factor activity
RVR_RS09750	COG4221	oxidoreductase activity
RVR_RS09765	COG3022	response to hydroperoxide
RVR_RS09770	COG0800	Aldolase
RVR_RS09785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RVR_RS09805	COG4585	Histidine kinase
RVR_RS09825	COG0860	N-Acetylmuramoyl-L-alanine amidase
RVR_RS09835	COG2124	cytochrome p450
RVR_RS09865	COG0667	Aldo Keto reductase
RVR_RS09890	COG0438	transferase activity, transferring glycosyl groups
RVR_RS09895	COG1309	transcriptional regulator
RVR_RS09900	COG2197	response regulator
RVR_RS09935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RVR_RS09955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RVR_RS09975	COG1309	transcriptional regulator
RVR_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS10050	COG0477	Major facilitator Superfamily
RVR_RS10060	COG1358	cellular component organization or biogenesis
RVR_RS10115	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RVR_RS10130	COG0789	Transcriptional regulator
RVR_RS10140	COG1741	Belongs to the pirin family
RVR_RS10155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RVR_RS10160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RVR_RS10165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RVR_RS10170	COG2084	Dehydrogenase
RVR_RS10185	COG1764	response to oxidative stress
RVR_RS10215	COG2837	iron assimilation
RVR_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS10240	COG1653	transport
RVR_RS10270	COG0321	lipoyl(octanoyl) transferase activity
RVR_RS10270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RVR_RS10280	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS10295	COG3842	ATPase activity
RVR_RS10315	COG0673	inositol 2-dehydrogenase activity
RVR_RS10330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RVR_RS10345	COG0745	RESPONSE REGULATOR receiver
RVR_RS10365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RVR_RS10410	COG1960	acyl-CoA dehydrogenase activity
RVR_RS10415	COG0702	epimerase
RVR_RS10420	COG0702	epimerase
RVR_RS10445	COG0277	FAD linked oxidase domain protein
RVR_RS10460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RVR_RS10480	COG2272	Belongs to the type-B carboxylesterase lipase family
RVR_RS10490	COG2079	MmgE PrpD family protein
RVR_RS10495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RVR_RS10500	COG2301	Belongs to the HpcH HpaI aldolase family
RVR_RS10530	COG1070	Carbohydrate kinase
RVR_RS10565	COG0358	DNA primase activity
RVR_RS10595	COG2188	Transcriptional regulator
RVR_RS10600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RVR_RS10605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RVR_RS10615	COG1733	regulation of RNA biosynthetic process
RVR_RS10620	COG0702	epimerase
RVR_RS10635	COG0714	Associated with various cellular activities
RVR_RS10640	COG3552	Protein containing von Willebrand factor type A (VWA) domain
RVR_RS10665	COG2146	nitrite reductase [NAD(P)H] activity
RVR_RS10665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RVR_RS10700	COG0574	Belongs to the PEP-utilizing enzyme family
RVR_RS10700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RVR_RS10705	COG1051	belongs to the nudix hydrolase family
RVR_RS10735	COG0477	Major facilitator Superfamily
RVR_RS10750	COG0423	glycine-tRNA ligase activity
RVR_RS10755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RVR_RS10760	COG1381	Involved in DNA repair and RecF pathway recombination
RVR_RS10770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RVR_RS10795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RVR_RS10830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RVR_RS10840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RVR_RS10845	COG1486	melibiose metabolic process
RVR_RS10855	COG1234	tRNA 3'-trailer cleavage
RVR_RS10860	COG0537	adenosine 5'-monophosphoramidase activity
RVR_RS10870	COG4946	Tricorn protease homolog
RVR_RS10870	COG0793	Belongs to the peptidase S41A family
RVR_RS10875	COG1472	Belongs to the glycosyl hydrolase 3 family
RVR_RS10885	COG1720	tRNA m6t6A37 methyltransferase activity
RVR_RS10940	COG0484	heat shock protein binding
RVR_RS10945	COG1420	regulation of RNA biosynthetic process
RVR_RS10970	COG0481	GTPase activity
RVR_RS10975	COG0268	Binds directly to 16S ribosomal RNA
RVR_RS10995	COG1307	EDD domain protein, DegV family
RVR_RS11005	COG0495	leucyl-tRNA aminoacylation
RVR_RS11020	COG1902	pentaerythritol trinitrate reductase activity
RVR_RS11030	COG0588	phosphoglycerate mutase activity
RVR_RS11045	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RVR_RS11055	COG0501	Belongs to the peptidase M48B family
RVR_RS11065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RVR_RS11075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RVR_RS11095	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
RVR_RS11155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RVR_RS11160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RVR_RS11165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RVR_RS11170	COG1530	ribonuclease E activity
RVR_RS11210	COG0772	Belongs to the SEDS family
RVR_RS11215	COG0768	penicillin binding
RVR_RS11230	COG1077	Cell shape determining protein MreB Mrl
RVR_RS11235	COG0105	UTP biosynthetic process
RVR_RS11245	COG0285	dihydrofolate synthase activity
RVR_RS11250	COG0525	valine-tRNA ligase activity
RVR_RS11265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RVR_RS11270	COG0740	serine-type endopeptidase activity
RVR_RS11275	COG0740	serine-type endopeptidase activity
RVR_RS11280	COG0544	peptidyl-prolyl cis-trans isomerase activity
RVR_RS11300	COG4552	Acetyltransferase involved in intracellular survival and related
RVR_RS11315	COG0252	asparaginase activity
RVR_RS11340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RVR_RS11365	COG0577	efflux transmembrane transporter activity
RVR_RS11365	COG1136	(ABC) transporter
RVR_RS11405	COG0668	transmembrane transport
RVR_RS11445	COG0300	oxidoreductase activity
RVR_RS11455	COG1595	DNA-templated transcription, initiation
RVR_RS11485	COG4977	sequence-specific DNA binding
RVR_RS11515	COG1175	transmembrane transport
RVR_RS11520	COG0395	ABC-type sugar transport system, permease component
RVR_RS11525	COG1486	melibiose metabolic process
RVR_RS11570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RVR_RS11590	COG1136	(ABC) transporter
RVR_RS11615	COG0629	single-stranded DNA binding
RVR_RS11620	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
RVR_RS11640	COG1309	transcriptional regulator
RVR_RS11675	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RVR_RS11680	COG2267	carboxylic ester hydrolase activity
RVR_RS11695	COG1846	Transcriptional regulator
RVR_RS11700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RVR_RS11730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RVR_RS11745	COG0673	inositol 2-dehydrogenase activity
RVR_RS11750	COG1609	Transcriptional regulator
RVR_RS11755	COG0456	acetyltransferase
RVR_RS11755	COG0454	-acetyltransferase
RVR_RS11770	COG1132	(ABC) transporter
RVR_RS11785	COG1946	Acyl-CoA thioesterase
RVR_RS11795	COG1309	transcriptional regulator
RVR_RS11800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RVR_RS11815	COG1960	acyl-CoA dehydrogenase activity
RVR_RS11825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RVR_RS11830	COG0589	response to stress
RVR_RS11835	COG4977	sequence-specific DNA binding
RVR_RS11840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RVR_RS11880	COG1175	transmembrane transport
RVR_RS11885	COG0395	ABC-type sugar transport system, permease component
RVR_RS11895	COG3979	chitinase
RVR_RS11920	COG2329	Antibiotic biosynthesis monooxygenase
RVR_RS11935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RVR_RS11940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RVR_RS11955	COG2226	methyltransferase
RVR_RS11970	COG0745	RESPONSE REGULATOR receiver
RVR_RS11990	COG0406	alpha-ribazole phosphatase activity
RVR_RS12020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RVR_RS12065	COG2207	Transcriptional regulator
RVR_RS12080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS12095	COG2807	transmembrane transport
RVR_RS12100	COG2186	Transcriptional regulator
RVR_RS12105	COG1357	PFAM Pentapeptide repeats (8 copies)
RVR_RS12115	COG0277	FAD linked oxidase domain protein
RVR_RS12115	COG0247	lactate metabolic process
RVR_RS12135	COG0673	inositol 2-dehydrogenase activity
RVR_RS12140	COG0179	Fumarylacetoacetate (FAA) hydrolase
RVR_RS12145	COG2733	membrane
RVR_RS12170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RVR_RS12205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RVR_RS12215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RVR_RS12220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RVR_RS12225	COG1234	tRNA 3'-trailer cleavage
RVR_RS12245	COG1113	amino acid transport
RVR_RS12255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RVR_RS12265	COG1335	isochorismatase
RVR_RS12290	COG0667	Aldo Keto reductase
RVR_RS12315	COG0277	FAD linked oxidase domain protein
RVR_RS12320	COG3185	4-Hydroxyphenylpyruvate dioxygenase
RVR_RS12330	COG1174	glycine betaine transport
RVR_RS12335	COG0517	IMP dehydrogenase activity
RVR_RS12335	COG1125	glycine betaine transport
RVR_RS12340	COG1174	glycine betaine transport
RVR_RS12345	COG1732	Glycine betaine
RVR_RS12395	COG4260	virion core protein, lumpy skin disease virus
RVR_RS12400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RVR_RS12410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RVR_RS12425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
RVR_RS12440	COG1678	Uncharacterized ACR, COG1678
RVR_RS12445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RVR_RS12450	COG0776	regulation of translation
RVR_RS12460	COG3973	AAA domain
RVR_RS12470	COG2223	nitrite transmembrane transporter activity
RVR_RS12480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RVR_RS12485	COG0793	Belongs to the peptidase S41A family
RVR_RS12490	COG2177	Part of the ABC transporter FtsEX involved in
RVR_RS12495	COG2884	Cell division ATP-binding protein ftsE
RVR_RS12510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RVR_RS12515	COG0515	serine threonine protein kinase
RVR_RS12520	COG0515	serine threonine protein kinase
RVR_RS12525	COG1674	ftsk spoiiie
RVR_RS12535	COG1175	transmembrane transport
RVR_RS12540	COG0395	ABC-type sugar transport system, permease component
RVR_RS12545	COG2902	Dehydrogenase
RVR_RS12565	COG0653	protein targeting
RVR_RS12575	COG3214	Protein conserved in bacteria
RVR_RS12580	COG2197	response regulator
RVR_RS12585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RVR_RS12595	COG0823	Involved in the tonB-independent uptake of proteins
RVR_RS12600	COG5000	phosphorelay sensor kinase activity
RVR_RS12600	COG5002	protein histidine kinase activity
RVR_RS12605	COG0745	RESPONSE REGULATOR receiver
RVR_RS12610	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RVR_RS12640	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RVR_RS12650	COG1482	cell wall glycoprotein biosynthetic process
RVR_RS12660	COG2835	tetraacyldisaccharide 4'-kinase activity
RVR_RS12665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RVR_RS12700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RVR_RS12705	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
RVR_RS12705	COG0778	Nitroreductase
RVR_RS12715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RVR_RS12725	COG1316	TRANSCRIPTIONal
RVR_RS12735	COG1316	TRANSCRIPTIONal
RVR_RS12750	COG1316	TRANSCRIPTIONal
RVR_RS12760	COG1316	TRANSCRIPTIONal
RVR_RS12780	COG1316	TRANSCRIPTIONal
RVR_RS12785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RVR_RS12800	COG0745	RESPONSE REGULATOR receiver
RVR_RS12805	COG2205	protein histidine kinase activity
RVR_RS12820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RVR_RS12840	COG1191	sigma factor activity
RVR_RS12845	COG1733	regulation of RNA biosynthetic process
RVR_RS12855	COG2409	Drug exporters of the RND superfamily
RVR_RS12860	COG1309	transcriptional regulator
RVR_RS12865	COG1228	amidohydrolase
RVR_RS12875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RVR_RS12880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RVR_RS12905	COG2409	Drug exporters of the RND superfamily
RVR_RS12910	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS12925	COG2755	lipolytic protein G-D-S-L family
RVR_RS12935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RVR_RS12975	COG0183	Belongs to the thiolase family
RVR_RS12995	COG0148	phosphopyruvate hydratase activity
RVR_RS13010	COG2124	cytochrome p450
RVR_RS13020	COG1515	deoxyribonuclease V activity
RVR_RS13040	COG2815	serine threonine protein kinase
RVR_RS13040	COG0515	serine threonine protein kinase
RVR_RS13065	COG0577	efflux transmembrane transporter activity
RVR_RS13065	COG1136	(ABC) transporter
RVR_RS13070	COG1136	(ABC) transporter
RVR_RS13080	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS13120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RVR_RS13125	COG2197	response regulator
RVR_RS13135	COG4106	trans-aconitate 2-methyltransferase activity
RVR_RS13145	COG0193	aminoacyl-tRNA hydrolase activity
RVR_RS13150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RVR_RS13155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RVR_RS13160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RVR_RS13180	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RVR_RS13205	COG0488	(ABC) transporter
RVR_RS13210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RVR_RS13215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RVR_RS13220	COG0084	hydrolase, TatD family'
RVR_RS13250	COG5297	Belongs to the glycosyl hydrolase family 6
RVR_RS13255	COG3573	Dehydrogenase
RVR_RS13260	COG4946	Tricorn protease homolog
RVR_RS13260	COG0793	Belongs to the peptidase S41A family
RVR_RS13280	COG2072	flavoprotein involved in K transport
RVR_RS13305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RVR_RS13310	COG2409	Drug exporters of the RND superfamily
RVR_RS13320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RVR_RS13345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RVR_RS13350	COG0521	Mo-molybdopterin cofactor biosynthetic process
RVR_RS13350	COG0315	cyclic pyranopterin monophosphate synthase activity
RVR_RS13355	COG0315	cyclic pyranopterin monophosphate synthase activity
RVR_RS13365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RVR_RS13370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RVR_RS13380	COG3263	regulation of cellular component size
RVR_RS13395	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RVR_RS13405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RVR_RS13420	COG1247	-acetyltransferase
RVR_RS13425	COG3384	dioxygenase
RVR_RS13445	COG1119	ATPase activity
RVR_RS13475	COG3460	Phenylacetate-CoA oxygenase
RVR_RS13480	COG3396	Phenylacetate-CoA oxygenase
RVR_RS13485	COG2151	metal-sulfur cluster biosynthetic enzyme
RVR_RS13490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RVR_RS13500	COG4974	Belongs to the 'phage' integrase family
RVR_RS13585	COG0500	methyltransferase
RVR_RS13595	COG1349	DNA-binding transcription factor activity
RVR_RS13600	COG1175	transmembrane transport
RVR_RS13605	COG0395	ABC-type sugar transport system, permease component
RVR_RS13615	COG3345	alpha-galactosidase
RVR_RS13625	COG1486	melibiose metabolic process
RVR_RS13630	COG1349	DNA-binding transcription factor activity
RVR_RS13645	COG0564	pseudouridine synthase activity
RVR_RS13660	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RVR_RS13710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RVR_RS13735	COG3903	Transcriptional regulator
RVR_RS13735	COG3629	intracellular signal transduction
RVR_RS13750	COG0515	serine threonine protein kinase
RVR_RS13750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RVR_RS13765	COG2072	flavoprotein involved in K transport
RVR_RS13775	COG4977	sequence-specific DNA binding
RVR_RS13785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RVR_RS13790	COG1366	Belongs to the anti-sigma-factor antagonist family
RVR_RS13835	COG1131	(ABC) transporter
RVR_RS13910	COG1674	ftsk spoiiie
RVR_RS13935	COG4821	SIS domain
RVR_RS13940	COG0259	pyridoxamine-phosphate oxidase activity
RVR_RS13950	COG0247	lactate metabolic process
RVR_RS13950	COG0277	FAD linked oxidase domain protein
RVR_RS13955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RVR_RS13965	COG0667	Aldo Keto reductase
RVR_RS13990	COG2252	PERMEase
RVR_RS14000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RVR_RS14015	COG2814	Major facilitator Superfamily
RVR_RS14025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RVR_RS14030	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RVR_RS14035	COG1278	Cold shock
RVR_RS14070	COG1061	Type III restriction enzyme res subunit
RVR_RS14080	COG3973	AAA domain
RVR_RS14095	COG1309	transcriptional regulator
RVR_RS14110	COG2376	Dihydroxyacetone kinase
RVR_RS14115	COG2376	Dihydroxyacetone kinase
RVR_RS14145	COG1737	Transcriptional regulator
RVR_RS14150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RVR_RS14155	COG0386	Belongs to the glutathione peroxidase family
RVR_RS14165	COG1278	Cold shock
RVR_RS14180	COG0463	Glycosyl transferase, family 2
RVR_RS14210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RVR_RS14230	COG0649	NAD binding
RVR_RS14240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RVR_RS14260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RVR_RS14265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RVR_RS14280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RVR_RS14280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RVR_RS14285	COG0302	gtp cyclohydrolase
RVR_RS14295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RVR_RS14300	COG0037	tRNA processing
RVR_RS14310	COG2027	D-alanyl-D-alanine carboxypeptidase
RVR_RS14315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RVR_RS14320	COG0477	Major facilitator Superfamily
RVR_RS14335	COG4941	Belongs to the sigma-70 factor family
RVR_RS14340	COG3795	YCII-related domain
RVR_RS14350	COG1595	DNA-templated transcription, initiation
RVR_RS14395	COG2814	Major facilitator Superfamily
RVR_RS14400	COG1309	transcriptional regulator
RVR_RS14435	COG0076	glutamate decarboxylase activity
RVR_RS14440	COG3360	Dodecin
RVR_RS14450	COG1077	Cell shape determining protein MreB Mrl
RVR_RS14465	COG0501	Belongs to the peptidase M48B family
RVR_RS14490	COG2353	YceI-like domain
RVR_RS14505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RVR_RS14515	COG3629	intracellular signal transduction
RVR_RS14515	COG3903	Transcriptional regulator
RVR_RS14525	COG0412	Dienelactone hydrolase
RVR_RS14535	COG2814	Major facilitator Superfamily
RVR_RS14550	COG3850	Histidine kinase
RVR_RS14555	COG2197	response regulator
RVR_RS14585	COG1285	pathogenesis
RVR_RS14635	COG0655	NAD(P)H dehydrogenase (quinone) activity
RVR_RS14640	COG1595	DNA-templated transcription, initiation
RVR_RS14645	COG3903	Transcriptional regulator
RVR_RS14645	COG3629	intracellular signal transduction
RVR_RS14660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RVR_RS14665	COG0142	geranyltranstransferase activity
RVR_RS14675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RVR_RS14690	COG3425	synthase
RVR_RS14715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RVR_RS14735	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS14740	COG2345	Transcriptional regulator
RVR_RS14745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RVR_RS14755	COG3424	synthase
RVR_RS14775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RVR_RS14805	COG0539	negative regulation of cytoplasmic translation
RVR_RS14870	COG0419	ATPase involved in DNA repair
RVR_RS14920	COG3328	transposase activity
RVR_RS14955	COG0470	DNA polymerase III
RVR_RS14970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RVR_RS15000	COG0739	heme binding
RVR_RS15000	COG0741	lytic transglycosylase activity
RVR_RS15000	COG1196	nuclear chromosome segregation
RVR_RS15010	COG0243	molybdopterin cofactor binding
RVR_RS15095	COG0513	Belongs to the DEAD box helicase family
RVR_RS15115	COG3250	beta-galactosidase activity
RVR_RS15125	COG1609	Transcriptional regulator
RVR_RS15135	COG1653	transport
RVR_RS15140	COG1175	transmembrane transport
RVR_RS15145	COG0395	ABC-type sugar transport system, permease component
RVR_RS15165	COG0640	Transcriptional regulator
RVR_RS15180	COG3033	Beta-eliminating lyase
RVR_RS15220	COG1316	TRANSCRIPTIONal
RVR_RS15230	COG1316	TRANSCRIPTIONal
RVR_RS15240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RVR_RS15250	COG0477	Major facilitator Superfamily
RVR_RS15275	COG1595	DNA-templated transcription, initiation
RVR_RS15295	COG1584	GPR1 FUN34 yaaH family protein
RVR_RS15315	COG3275	phosphorelay sensor kinase activity
RVR_RS15330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RVR_RS15335	COG1132	(ABC) transporter
RVR_RS15355	COG4221	oxidoreductase activity
RVR_RS15380	COG1643	Atp-dependent helicase
RVR_RS15400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RVR_RS15410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RVR_RS15455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RVR_RS15460	COG0047	phosphoribosylformylglycinamidine synthase activity
RVR_RS15465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RVR_RS15495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RVR_RS15510	COG0151	Belongs to the GarS family
RVR_RS15525	COG1802	Transcriptional regulator
RVR_RS15530	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RVR_RS15530	COG0515	serine threonine protein kinase
RVR_RS15535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RVR_RS15545	COG2124	cytochrome p450
RVR_RS15550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RVR_RS15580	COG0003	Pfam Anion-transporting ATPase
RVR_RS15590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RVR_RS15600	COG1408	metallophosphoesterase
RVR_RS15610	COG1609	Transcriptional regulator
RVR_RS16250	COG1609	Transcriptional regulator
RVR_RS16345	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RVR_RS16440	COG0747	negative chemotaxis
RVR_RS16445	COG0601	transmembrane transport
RVR_RS16450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS16455	COG4172	Belongs to the ABC transporter superfamily
RVR_RS16500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RVR_RS16505	COG1397	ADP-ribosylglycohydrolase
RVR_RS16510	COG0326	Molecular chaperone. Has ATPase activity
RVR_RS16530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RVR_RS16535	COG2084	Dehydrogenase
RVR_RS16570	COG1595	DNA-templated transcription, initiation
RVR_RS16585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RVR_RS16590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RVR_RS16695	COG0494	nUDIX hydrolase
RVR_RS16765	COG3328	transposase activity
RVR_RS16800	COG0277	FAD linked oxidase domain protein
RVR_RS16805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RVR_RS16820	COG4565	transcriptional regulatory protein
RVR_RS16825	COG3290	protein histidine kinase activity
RVR_RS16830	COG1301	dicarboxylic acid transport
RVR_RS16870	COG1672	PFAM Archaeal ATPase
RVR_RS16870	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RVR_RS16895	COG3469	chitinase activity
RVR_RS16900	COG1408	metallophosphoesterase
RVR_RS16955	COG1404	Belongs to the peptidase S8 family
RVR_RS16975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RVR_RS17035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RVR_RS17045	COG1278	Cold shock
RVR_RS17050	COG0513	Belongs to the DEAD box helicase family
RVR_RS17085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RVR_RS17095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RVR_RS17150	COG0438	transferase activity, transferring glycosyl groups
RVR_RS17155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RVR_RS17175	COG0438	transferase activity, transferring glycosyl groups
RVR_RS17245	COG2770	Histidine kinase
RVR_RS17245	COG2208	phosphoserine phosphatase activity
RVR_RS17265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RVR_RS17300	COG1191	sigma factor activity
RVR_RS17305	COG1191	sigma factor activity
RVR_RS17315	COG0667	Aldo Keto reductase
RVR_RS17330	COG0463	Glycosyl transferase, family 2
RVR_RS17335	COG2205	protein histidine kinase activity
RVR_RS17340	COG0745	RESPONSE REGULATOR receiver
RVR_RS17345	COG1660	Displays ATPase and GTPase activities
RVR_RS17350	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RVR_RS17360	COG0181	hydroxymethylbilane synthase activity
RVR_RS17365	COG2130	NADP-dependent
RVR_RS17395	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS17400	COG1595	DNA-templated transcription, initiation
RVR_RS17420	COG3511	phospholipase C
RVR_RS17435	COG4221	oxidoreductase activity
RVR_RS17445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RVR_RS17460	COG0653	protein targeting
RVR_RS17480	COG0006	proline dipeptidase activity
RVR_RS17510	COG2372	response to copper ion
RVR_RS17510	COG1276	copper resistance
RVR_RS17515	COG2837	iron assimilation
RVR_RS17520	COG0077	Prephenate dehydratase
RVR_RS17525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RVR_RS17530	COG0561	phosphatase activity
RVR_RS17545	COG1131	(ABC) transporter
RVR_RS17555	COG1131	(ABC) transporter
RVR_RS17615	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RVR_RS17620	COG1140	nitrate reductase beta subunit
RVR_RS17640	COG0561	phosphatase activity
RVR_RS17645	COG4988	ABC transporter
RVR_RS17650	COG1294	oxidase, subunit
RVR_RS17655	COG1271	oxidase subunit
RVR_RS17660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RVR_RS17665	COG1609	Transcriptional regulator
RVR_RS17685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RVR_RS17700	COG0662	Cupin 2, conserved barrel domain protein
RVR_RS17705	COG1950	PFAM Membrane protein of
RVR_RS17710	COG0626	cystathionine gamma-synthase activity
RVR_RS17745	COG1472	Belongs to the glycosyl hydrolase 3 family
RVR_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS17780	COG0305	Participates in initiation and elongation during chromosome replication
RVR_RS17790	COG0359	binds to the 23S rRNA
RVR_RS17795	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RVR_RS17800	COG0629	single-stranded DNA binding
RVR_RS17805	COG0360	Binds together with S18 to 16S ribosomal RNA
RVR_RS17830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RVR_RS17850	COG0617	tRNA 3'-terminal CCA addition
RVR_RS17870	COG1595	DNA-templated transcription, initiation
RVR_RS17880	COG0492	ferredoxin-NADP+ reductase activity
RVR_RS17885	COG3118	belongs to the thioredoxin family
RVR_RS17900	COG1192	Involved in chromosome partitioning
RVR_RS17905	COG0357	Ribosomal RNA small subunit methyltransferase G
RVR_RS17915	COG0706	membrane insertase activity
RVR_RS17920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RVR_RS17925	COG0594	ribonuclease P activity
RVR_RS17930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RVR_RS17935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RVR_RS17940	COG0592	DNA-directed DNA polymerase activity
RVR_RS17945	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
RVR_RS17950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RVR_RS17955	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
RVR_RS17965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RVR_RS17970	COG3266	domain, Protein
RVR_RS17990	COG0515	serine threonine protein kinase
RVR_RS18005	COG4974	Belongs to the 'phage' integrase family
RVR_RS18095	COG0705	Rhomboid family
RVR_RS18120	COG3764	Sortase (surface protein transpeptidase)
RVR_RS18125	COG3764	Sortase (surface protein transpeptidase)
RVR_RS18130	COG0515	serine threonine protein kinase
RVR_RS18135	COG0768	penicillin binding
RVR_RS18150	COG1716	ATPase activity
RVR_RS18155	COG1716	ATPase activity
RVR_RS18170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RVR_RS18175	COG1733	regulation of RNA biosynthetic process
RVR_RS18230	COG1250	3-hydroxyacyl-CoA dehydrogenase
RVR_RS18240	COG1522	sequence-specific DNA binding
RVR_RS18255	COG0508	dehydrogenase complex catalyzes the overall conversion of
RVR_RS18265	COG0303	'Molybdopterin
RVR_RS18270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RVR_RS18275	COG0477	Major facilitator Superfamily
RVR_RS18285	COG0604	alcohol dehydrogenase
RVR_RS18300	COG0515	serine threonine protein kinase
RVR_RS18305	COG0515	serine threonine protein kinase
RVR_RS18320	COG0022	dehydrogenase e1 component
RVR_RS18325	COG0508	dehydrogenase complex catalyzes the overall conversion of
RVR_RS18360	COG2018	Roadblock/LC7 domain
RVR_RS18365	COG0642	Histidine kinase
RVR_RS18410	COG1362	aminopeptidase activity
RVR_RS18415	COG1960	acyl-CoA dehydrogenase activity
RVR_RS18425	COG1741	Belongs to the pirin family
RVR_RS18450	COG0583	DNA-binding transcription factor activity
RVR_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS18550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RVR_RS18570	COG1595	DNA-templated transcription, initiation
RVR_RS18585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RVR_RS18605	COG1316	TRANSCRIPTIONal
RVR_RS18660	COG2205	protein histidine kinase activity
RVR_RS18665	COG0745	RESPONSE REGULATOR receiver
RVR_RS18675	COG1136	(ABC) transporter
RVR_RS18675	COG0577	efflux transmembrane transporter activity
RVR_RS18680	COG4591	ABC-type transport system involved in lipoprotein release permease component
RVR_RS18680	COG1136	(ABC) transporter
RVR_RS18685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RVR_RS18685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RVR_RS18710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RVR_RS18715	COG1595	DNA-templated transcription, initiation
RVR_RS18720	COG0667	Aldo Keto reductase
RVR_RS18745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RVR_RS18775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RVR_RS18800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RVR_RS18805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RVR_RS18830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RVR_RS18835	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS18840	COG1309	transcriptional regulator
RVR_RS18850	COG2304	oxidoreductase activity
RVR_RS18855	COG0395	ABC-type sugar transport system, permease component
RVR_RS18870	COG1609	Transcriptional regulator
RVR_RS18880	COG3458	cephalosporin-C deacetylase activity
RVR_RS18910	COG0395	ABC-type sugar transport system, permease component
RVR_RS18915	COG1175	transmembrane transport
RVR_RS18925	COG1609	Transcriptional regulator
RVR_RS18940	COG2814	Major facilitator Superfamily
RVR_RS19040	COG0464	growth
RVR_RS19050	COG2197	response regulator
RVR_RS19075	COG1595	DNA-templated transcription, initiation
RVR_RS19105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS19125	COG1595	DNA-templated transcription, initiation
RVR_RS19135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS19140	COG0596	Alpha beta hydrolase
RVR_RS19150	COG0714	Associated with various cellular activities
RVR_RS19200	COG1309	transcriptional regulator
RVR_RS19220	COG4585	Histidine kinase
RVR_RS19225	COG2197	response regulator
RVR_RS19270	COG0154	amidase activity
RVR_RS19300	COG0477	Major facilitator Superfamily
RVR_RS19325	COG1595	DNA-templated transcription, initiation
RVR_RS19350	COG1397	ADP-ribosylglycohydrolase
RVR_RS19360	COG1401	restriction endodeoxyribonuclease activity
RVR_RS19365	COG0069	glutamate synthase activity
RVR_RS19370	COG0028	Belongs to the TPP enzyme family
RVR_RS19410	COG4989	oxidoreductase activity
RVR_RS19450	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RVR_RS19455	COG0515	serine threonine protein kinase
RVR_RS19555	COG1518	maintenance of DNA repeat elements
RVR_RS19680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RVR_RS19725	COG0717	Belongs to the dCTP deaminase family
RVR_RS19745	COG0247	lactate metabolic process
RVR_RS19745	COG2181	nitrate reductase activity
RVR_RS19750	COG0443	Heat shock 70 kDa protein
RVR_RS19755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RVR_RS19760	COG0484	heat shock protein binding
RVR_RS19765	COG0789	Transcriptional regulator
RVR_RS19790	COG2124	cytochrome p450
RVR_RS19795	COG0542	response to heat
RVR_RS19810	COG0137	argininosuccinate synthase activity
RVR_RS19840	COG0709	Synthesizes selenophosphate from selenide and ATP
RVR_RS19855	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RVR_RS19890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RVR_RS19895	COG0191	fructose-bisphosphate aldolase activity
RVR_RS19905	COG3483	tryptophan 2,3-dioxygenase activity
RVR_RS19910	COG3844	kynureninase activity
RVR_RS19940	COG0596	Alpha beta hydrolase
RVR_RS19950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RVR_RS19955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RVR_RS20010	COG1205	dead DEAH box helicase
RVR_RS20010	COG1111	helicase
RVR_RS20015	COG1366	Belongs to the anti-sigma-factor antagonist family
RVR_RS20020	COG2172	sigma factor antagonist activity
RVR_RS20030	COG2890	protein-(glutamine-N5) methyltransferase activity
RVR_RS20045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RVR_RS20045	COG1754	DNA topoisomerase type I activity
RVR_RS20050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RVR_RS20075	COG1252	NADH dehydrogenase
RVR_RS20130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RVR_RS20170	COG0739	heme binding
RVR_RS20170	COG1196	nuclear chromosome segregation
RVR_RS20170	COG0741	lytic transglycosylase activity
RVR_RS20180	COG0277	FAD linked oxidase domain protein
RVR_RS20200	COG1937	Protein conserved in bacteria
RVR_RS20230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RVR_RS20235	COG0494	nUDIX hydrolase
RVR_RS20235	COG0406	alpha-ribazole phosphatase activity
RVR_RS20250	COG0456	acetyltransferase
RVR_RS20255	COG2271	Major facilitator Superfamily
RVR_RS20260	COG2205	protein histidine kinase activity
RVR_RS20265	COG0745	RESPONSE REGULATOR receiver
RVR_RS20270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RVR_RS20275	COG1609	Transcriptional regulator
RVR_RS20280	COG0745	RESPONSE REGULATOR receiver
RVR_RS20305	COG2897	thiosulfate sulfurtransferase activity
RVR_RS20335	COG3485	protocatechuate 3,4-dioxygenase
RVR_RS20340	COG0735	belongs to the Fur family
RVR_RS20345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RVR_RS20350	COG1490	D-aminoacyl-tRNA deacylase activity
RVR_RS20360	COG4552	Acetyltransferase involved in intracellular survival and related
RVR_RS20370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RVR_RS20435	COG0613	PHP domain protein
RVR_RS20485	COG0438	transferase activity, transferring glycosyl groups
RVR_RS20495	COG0588	phosphoglycerate mutase activity
RVR_RS20505	COG1846	Transcriptional regulator
RVR_RS20520	COG5002	protein histidine kinase activity
RVR_RS20535	COG1329	Transcriptional regulator
RVR_RS20540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RVR_RS20545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RVR_RS20550	COG0215	cysteine-tRNA ligase activity
RVR_RS20570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RVR_RS20580	COG3842	ATPase activity
RVR_RS20965	COG1595	DNA-templated transcription, initiation
RVR_RS20980	COG3537	Alpha-1,2-mannosidase
RVR_RS21005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RVR_RS21025	COG2197	response regulator
RVR_RS21045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RVR_RS21050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RVR_RS21055	COG0157	Belongs to the NadC ModD family
RVR_RS21060	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RVR_RS21080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RVR_RS21105	COG0739	heme binding
RVR_RS21110	COG1309	transcriptional regulator
RVR_RS21120	COG2205	protein histidine kinase activity
RVR_RS21125	COG0745	RESPONSE REGULATOR receiver
RVR_RS21135	COG1595	DNA-templated transcription, initiation
RVR_RS21150	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
RVR_RS21170	COG0248	Ppx GppA phosphatase
RVR_RS21175	COG1082	Xylose isomerase domain protein TIM barrel
RVR_RS21180	COG0129	dihydroxy-acid dehydratase activity
RVR_RS21190	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS21195	COG1309	transcriptional regulator
RVR_RS21205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RVR_RS21210	COG0180	Tryptophanyl-tRNA synthetase
RVR_RS21230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RVR_RS21240	COG0123	including yeast histone deacetylase and acetoin utilization protein
RVR_RS21300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
RVR_RS21305	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RVR_RS21310	COG0181	hydroxymethylbilane synthase activity
RVR_RS21315	COG1648	precorrin-2 dehydrogenase activity
RVR_RS21315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RVR_RS21320	COG0113	porphobilinogen synthase activity
RVR_RS21335	COG0018	arginyl-trna synthetase
RVR_RS21340	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
RVR_RS21360	COG1690	Belongs to the RtcB family
RVR_RS21370	COG5434	Belongs to the glycosyl hydrolase 28 family
RVR_RS21385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RVR_RS21390	COG0406	alpha-ribazole phosphatase activity
RVR_RS21400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RVR_RS21405	COG0785	Cytochrome C biogenesis protein
RVR_RS21410	COG1333	cytochrome c biogenesis protein
RVR_RS21415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RVR_RS21425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RVR_RS21430	COG0109	protoheme IX farnesyltransferase activity
RVR_RS21445	COG0163	prenyltransferase activity
RVR_RS21450	COG1522	sequence-specific DNA binding
RVR_RS21455	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RVR_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS21490	COG0183	Belongs to the thiolase family
RVR_RS21500	COG1278	Cold shock
RVR_RS21505	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RVR_RS21510	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RVR_RS21515	COG2226	methyltransferase
RVR_RS21540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RVR_RS21545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RVR_RS21550	COG0649	NAD binding
RVR_RS21560	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RVR_RS21565	COG1034	ATP synthesis coupled electron transport
RVR_RS21570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RVR_RS21575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RVR_RS21580	COG0839	Belongs to the complex I subunit 6 family
RVR_RS21585	COG0713	ATP synthesis coupled electron transport
RVR_RS21590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RVR_RS21600	COG1007	ATP synthesis coupled electron transport
RVR_RS21635	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RVR_RS21640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RVR_RS21645	COG3572	ergothioneine biosynthetic process
RVR_RS21650	COG0142	geranyltranstransferase activity
RVR_RS21675	COG0702	epimerase
RVR_RS21680	COG1733	regulation of RNA biosynthetic process
RVR_RS21685	COG1013	pyruvate-flavodoxin oxidoreductase activity
RVR_RS21690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RVR_RS21690	COG0674	pyruvate-flavodoxin oxidoreductase activity
RVR_RS21720	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RVR_RS21725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RVR_RS21730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RVR_RS21735	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RVR_RS21740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RVR_RS21750	COG0713	ATP synthesis coupled electron transport
RVR_RS21755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RVR_RS21760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RVR_RS21765	COG1007	ATP synthesis coupled electron transport
RVR_RS21770	COG0501	Belongs to the peptidase M48B family
RVR_RS21775	COG3304	Inner membrane component domain
RVR_RS21780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RVR_RS21785	COG1666	GTP binding
RVR_RS21835	COG1674	ftsk spoiiie
RVR_RS21855	COG2188	Transcriptional regulator
RVR_RS21875	COG2188	Transcriptional regulator
RVR_RS21920	COG2175	clavaminate synthase activity
RVR_RS21925	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RVR_RS21930	COG4521	taurine ABC transporter
RVR_RS21935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RVR_RS21965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RVR_RS21985	COG2205	protein histidine kinase activity
RVR_RS21990	COG2018	Roadblock/LC7 domain
RVR_RS22005	COG0702	epimerase
RVR_RS22025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RVR_RS22030	COG2030	dehydratase
RVR_RS22040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RVR_RS22045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RVR_RS22050	COG0436	Aminotransferase
RVR_RS22065	COG0250	Participates in transcription elongation, termination and antitermination
RVR_RS22070	COG2755	lipolytic protein G-D-S-L family
RVR_RS22085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RVR_RS22090	COG0081	regulation of translation
RVR_RS22095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RVR_RS22100	COG0222	ribosome binding
RVR_RS22105	COG0085	RNA polymerase activity
RVR_RS22110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RVR_RS22115	COG0477	Major facilitator Superfamily
RVR_RS22130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RVR_RS22135	COG0049	tRNA binding
RVR_RS22140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RVR_RS22145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RVR_RS22165	COG0051	transcription antitermination factor activity, RNA binding
RVR_RS22170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RVR_RS22175	COG0088	Forms part of the polypeptide exit tunnel
RVR_RS22180	COG0089	rRNA binding
RVR_RS22185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RVR_RS22190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RVR_RS22195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RVR_RS22200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RVR_RS22205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RVR_RS22210	COG0255	Belongs to the universal ribosomal protein uL29 family
RVR_RS22215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RVR_RS22220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RVR_RS22225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RVR_RS22230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RVR_RS22235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RVR_RS22240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RVR_RS22245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RVR_RS22250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RVR_RS22255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RVR_RS22260	COG1841	ribosomal large subunit assembly
RVR_RS22265	COG0200	Binds to the 23S rRNA
RVR_RS22275	COG0563	adenylate kinase activity
RVR_RS22285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RVR_RS22290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RVR_RS22295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RVR_RS22300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RVR_RS22305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RVR_RS22315	COG0203	ribosomal protein L17
RVR_RS22320	COG0101	tRNA pseudouridine synthase activity
RVR_RS22330	COG0488	(ABC) transporter
RVR_RS22335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RVR_RS22340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RVR_RS22345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RVR_RS22350	COG1072	(Pantothenic acid kinase))
RVR_RS22355	COG0736	holo-[acyl-carrier-protein] synthase activity
RVR_RS22360	COG4115	mRNA cleavage
RVR_RS22365	COG2161	toxin-antitoxin pair type II binding
RVR_RS22375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RVR_RS22385	COG0802	atpase or kinase
RVR_RS22405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RVR_RS22420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RVR_RS22425	COG0459	protein refolding
RVR_RS22435	COG2258	MOSC domain
RVR_RS22445	COG0583	DNA-binding transcription factor activity
RVR_RS22455	COG2197	response regulator
RVR_RS22460	COG1595	DNA-templated transcription, initiation
RVR_RS22470	COG0516	GMP reductase activity
RVR_RS22485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RVR_RS22490	COG0515	serine threonine protein kinase
RVR_RS22490	COG2815	serine threonine protein kinase
RVR_RS22495	COG0515	serine threonine protein kinase
RVR_RS22495	COG2815	serine threonine protein kinase
RVR_RS22505	COG1012	belongs to the aldehyde dehydrogenase family
RVR_RS22520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RVR_RS22520	COG0519	Catalyzes the synthesis of GMP from XMP
RVR_RS22545	COG2197	response regulator
RVR_RS22605	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RVR_RS22605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RVR_RS22620	COG0714	Associated with various cellular activities
RVR_RS22630	COG3552	Protein containing von Willebrand factor type A (VWA) domain
RVR_RS22635	COG0045	succinate-CoA ligase (ADP-forming) activity
RVR_RS22665	COG0138	bifunctional purine biosynthesis protein purh
RVR_RS22670	COG1714	RDD family
RVR_RS22675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RVR_RS22690	COG0039	L-malate dehydrogenase activity
RVR_RS22695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RVR_RS22700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RVR_RS22720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RVR_RS22725	COG0180	Tryptophanyl-tRNA synthetase
RVR_RS22745	COG0671	phosphoesterase, PA-phosphatase related
RVR_RS22765	COG1686	Belongs to the peptidase S11 family
RVR_RS22785	COG2409	Drug exporters of the RND superfamily
RVR_RS22795	COG2205	protein histidine kinase activity
RVR_RS22805	COG1053	succinate dehydrogenase
RVR_RS22815	COG2009	succinate dehydrogenase
RVR_RS22850	COG1216	Glycosyl transferase, family 2
RVR_RS22865	COG2089	acid synthase
RVR_RS22890	COG2205	protein histidine kinase activity
RVR_RS22910	COG1473	amidohydrolase
RVR_RS22910	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RVR_RS22915	COG1744	ABC transporter substrate-binding protein PnrA-like
RVR_RS22920	COG3845	ABC transporter
RVR_RS22925	COG4603	Belongs to the binding-protein-dependent transport system permease family
RVR_RS22930	COG1079	Belongs to the binding-protein-dependent transport system permease family
RVR_RS22965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RVR_RS22985	COG2205	protein histidine kinase activity
RVR_RS22990	COG0745	RESPONSE REGULATOR receiver
RVR_RS22995	COG1595	DNA-templated transcription, initiation
RVR_RS23010	COG1012	belongs to the aldehyde dehydrogenase family
RVR_RS23015	COG1012	belongs to the aldehyde dehydrogenase family
RVR_RS23030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RVR_RS23065	COG4770	biotin carboxylase activity
RVR_RS23075	COG0424	maF-like protein
RVR_RS23085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RVR_RS23105	COG1024	Enoyl-CoA hydratase
RVR_RS23110	COG2986	histidine ammonia-lyase
RVR_RS23125	COG1940	carbohydrate kinase activity
RVR_RS23145	COG1136	(ABC) transporter
RVR_RS23150	COG1733	regulation of RNA biosynthetic process
RVR_RS23175	COG1846	Transcriptional regulator
RVR_RS23180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RVR_RS23195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RVR_RS23210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RVR_RS23235	COG1331	Highly conserved protein containing a thioredoxin domain
RVR_RS23245	COG0477	Major facilitator Superfamily
RVR_RS23255	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RVR_RS23270	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RVR_RS23310	COG2894	cell division
RVR_RS23365	COG0667	Aldo Keto reductase
RVR_RS23370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RVR_RS23375	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RVR_RS23395	COG1136	(ABC) transporter
RVR_RS23425	COG4106	trans-aconitate 2-methyltransferase activity
RVR_RS23435	COG0114	fumarate hydratase activity
RVR_RS23470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RVR_RS23470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RVR_RS23495	COG1722	exodeoxyribonuclease VII activity
RVR_RS23510	COG1570	exodeoxyribonuclease VII activity
RVR_RS23515	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RVR_RS23530	COG0012	GTP binding
RVR_RS23575	COG1309	transcriptional regulator
RVR_RS23605	COG2130	NADP-dependent
RVR_RS23635	COG3469	chitinase activity
RVR_RS23655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RVR_RS23680	COG2318	DinB family
RVR_RS23710	COG1842	Phage shock protein A
RVR_RS23725	COG1053	succinate dehydrogenase
RVR_RS23745	COG1217	gtp-binding protein TYPA
RVR_RS23750	COG0747	negative chemotaxis
RVR_RS23755	COG0601	transmembrane transport
RVR_RS23760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS23765	COG0444	Belongs to the ABC transporter superfamily
RVR_RS23770	COG4608	Belongs to the ABC transporter superfamily
RVR_RS23775	COG4166	transmembrane transport
RVR_RS23780	COG0601	transmembrane transport
RVR_RS23785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS23790	COG0444	Belongs to the ABC transporter superfamily
RVR_RS23795	COG4608	Belongs to the ABC transporter superfamily
RVR_RS23800	COG4608	Belongs to the ABC transporter superfamily
RVR_RS23805	COG0444	Belongs to the ABC transporter superfamily
RVR_RS23810	COG0601	transmembrane transport
RVR_RS23815	COG0747	negative chemotaxis
RVR_RS23820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS23835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RVR_RS23855	COG4585	Histidine kinase
RVR_RS23865	COG1131	(ABC) transporter
RVR_RS23875	COG2197	response regulator
RVR_RS23880	COG2912	Transglutaminase-like superfamily
RVR_RS23885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RVR_RS23885	COG0456	acetyltransferase
RVR_RS23905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RVR_RS23910	COG1611	Belongs to the LOG family
RVR_RS23925	COG0519	Catalyzes the synthesis of GMP from XMP
RVR_RS23930	COG1024	Enoyl-CoA hydratase
RVR_RS23945	COG1595	DNA-templated transcription, initiation
RVR_RS23955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RVR_RS23995	COG0598	Magnesium transport protein CorA
RVR_RS24015	COG2095	MarC family integral membrane protein
RVR_RS24060	COG0395	ABC-type sugar transport system, permease component
RVR_RS24065	COG4209	transmembrane transport
RVR_RS24075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RVR_RS24105	COG0596	Alpha beta hydrolase
RVR_RS24175	COG0210	DNA helicase
RVR_RS24180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RVR_RS24190	COG1335	isochorismatase
RVR_RS24200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RVR_RS24235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RVR_RS24280	COG0314	molybdopterin synthase activity
RVR_RS24290	COG3480	Lon protease (S16) C-terminal proteolytic domain
RVR_RS24300	COG1615	UPF0182 protein
RVR_RS24335	COG0483	inositol monophosphate 1-phosphatase activity
RVR_RS24345	COG2076	Multidrug Resistance protein
RVR_RS24350	COG1162	GTPase activity
RVR_RS24355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RVR_RS24365	COG2135	peptidase activity
RVR_RS24375	COG1595	DNA-templated transcription, initiation
RVR_RS24380	COG5662	AntiSigma factor
RVR_RS24385	COG2199	diguanylate cyclase activity
RVR_RS24385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RVR_RS24395	COG0242	peptide deformylase activity
RVR_RS24400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RVR_RS24430	COG2188	Transcriptional regulator
RVR_RS24435	COG2182	Extracellular solute-binding protein
RVR_RS24440	COG1175	transmembrane transport
RVR_RS24445	COG0395	ABC-type sugar transport system, permease component
RVR_RS24450	COG1472	Belongs to the glycosyl hydrolase 3 family
RVR_RS24455	COG0363	glucosamine-6-phosphate deaminase activity
RVR_RS24470	COG1597	lipid kinase activity
RVR_RS24495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
RVR_RS24500	COG1737	Transcriptional regulator
RVR_RS24525	COG0681	Belongs to the peptidase S26 family
RVR_RS24540	COG0765	amino acid transport
RVR_RS24550	COG0281	malic enzyme
RVR_RS24555	COG0604	alcohol dehydrogenase
RVR_RS24610	COG0508	dehydrogenase complex catalyzes the overall conversion of
RVR_RS24610	COG0567	Dehydrogenase, E1 component
RVR_RS24615	COG2205	protein histidine kinase activity
RVR_RS24620	COG0745	RESPONSE REGULATOR receiver
RVR_RS24635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RVR_RS24655	COG5002	protein histidine kinase activity
RVR_RS24655	COG0784	Response regulator, receiver
RVR_RS24655	COG2198	Histidine kinase
RVR_RS24680	COG0791	NLP P60 protein
RVR_RS24695	COG1309	transcriptional regulator
RVR_RS24775	COG0512	Glutamine amidotransferase of anthranilate synthase
RVR_RS24775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RVR_RS24830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RVR_RS24865	COG1349	DNA-binding transcription factor activity
RVR_RS24870	COG2223	nitrite transmembrane transporter activity
RVR_RS24905	COG1120	ATPase activity
RVR_RS24930	COG2318	DinB family
RVR_RS24945	COG2018	Roadblock/LC7 domain
RVR_RS24965	COG2986	histidine ammonia-lyase
RVR_RS25015	COG2124	cytochrome p450
RVR_RS25040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RVR_RS25040	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RVR_RS25070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RVR_RS25075	COG1942	4-Oxalocrotonate Tautomerase
RVR_RS25080	COG1132	(ABC) transporter
RVR_RS25085	COG1132	(ABC) transporter
RVR_RS25085	COG2375	cellular response to nickel ion
RVR_RS25105	COG1021	2,3-dihydroxybenzoate-AMP ligase
RVR_RS25115	COG0402	S-adenosylhomocysteine deaminase activity
RVR_RS25120	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS25135	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RVR_RS25145	COG3903	Transcriptional regulator
RVR_RS25145	COG3629	intracellular signal transduction
RVR_RS25160	COG3321	synthase
RVR_RS25160	COG0604	alcohol dehydrogenase
RVR_RS25170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RVR_RS25170	COG2070	2-Nitropropane dioxygenase
RVR_RS25190	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RVR_RS25190	COG0493	'glutamate synthase
RVR_RS25230	COG0501	Belongs to the peptidase M48B family
RVR_RS25250	COG3953	SLT domain
RVR_RS25250	COG5412	phage tail tape measure protein
RVR_RS25255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS25270	COG2208	phosphoserine phosphatase activity
RVR_RS25270	COG2770	Histidine kinase
RVR_RS25305	COG1175	transmembrane transport
RVR_RS25310	COG0395	ABC-type sugar transport system, permease component
RVR_RS25315	COG0366	Alpha amylase catalytic
RVR_RS25350	COG0582	viral genome integration into host DNA
RVR_RS25390	COG1309	transcriptional regulator
RVR_RS25500	COG0745	RESPONSE REGULATOR receiver
RVR_RS25505	COG0018	arginyl-trna synthetase
RVR_RS25510	COG0019	diaminopimelate decarboxylase activity
RVR_RS25520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RVR_RS25525	COG0083	homoserine kinase activity
RVR_RS25535	COG1316	TRANSCRIPTIONal
RVR_RS25540	COG0254	rRNA binding
RVR_RS25545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RVR_RS25550	COG2890	protein-(glutamine-N5) methyltransferase activity
RVR_RS25565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RVR_RS25580	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RVR_RS25585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RVR_RS25590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RVR_RS25595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RVR_RS25600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RVR_RS25605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RVR_RS25610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RVR_RS25625	COG1250	3-hydroxyacyl-CoA dehydrogenase
RVR_RS25640	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
RVR_RS25685	COG0183	Belongs to the thiolase family
RVR_RS25750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RVR_RS25750	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RVR_RS25790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RVR_RS25795	COG0280	phosphate acetyltransferase
RVR_RS25795	COG0857	belongs to the CobB CobQ family
RVR_RS25800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RVR_RS25805	COG0205	6-phosphofructokinase activity
RVR_RS25825	COG0366	Alpha amylase catalytic
RVR_RS25830	COG0058	SHG alpha-glucan phosphorylase activity
RVR_RS25835	COG1278	Cold shock
RVR_RS25845	COG1132	(ABC) transporter
RVR_RS25850	COG1132	(ABC) transporter
RVR_RS25890	COG0454	-acetyltransferase
RVR_RS25905	COG1376	ErfK ybiS ycfS ynhG family protein
RVR_RS25910	COG1376	ErfK ybiS ycfS ynhG family protein
RVR_RS26025	COG0531	amino acid
RVR_RS26075	COG0765	amino acid transport
RVR_RS26080	COG0765	amino acid transport
RVR_RS26090	COG1126	abc transporter atp-binding protein
RVR_RS26100	COG1349	DNA-binding transcription factor activity
RVR_RS26110	COG4221	oxidoreductase activity
RVR_RS26115	COG3537	Alpha-1,2-mannosidase
RVR_RS26120	COG0179	Fumarylacetoacetate (FAA) hydrolase
RVR_RS26130	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS26145	COG0583	DNA-binding transcription factor activity
RVR_RS26160	COG1309	transcriptional regulator
RVR_RS26165	COG0667	Aldo Keto reductase
RVR_RS26215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RVR_RS26240	COG2197	response regulator
RVR_RS26245	COG1760	l-serine dehydratase
RVR_RS26250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RVR_RS26255	COG0509	glycine decarboxylation via glycine cleavage system
RVR_RS26260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RVR_RS26285	COG0747	negative chemotaxis
RVR_RS26295	COG0444	Belongs to the ABC transporter superfamily
RVR_RS26300	COG4608	Belongs to the ABC transporter superfamily
RVR_RS26305	COG1126	abc transporter atp-binding protein
RVR_RS26310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RVR_RS26315	COG0765	amino acid transport
RVR_RS26320	COG0765	amino acid transport
RVR_RS26335	COG0482	sulfurtransferase activity
RVR_RS26360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RVR_RS26370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RVR_RS26375	COG0154	amidase activity
RVR_RS26385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RVR_RS26390	COG2409	Drug exporters of the RND superfamily
RVR_RS26395	COG2133	pyrroloquinoline quinone binding
RVR_RS26400	COG0667	Aldo Keto reductase
RVR_RS26415	COG3300	MHYT domain
RVR_RS26415	COG5001	Diguanylate cyclase
RVR_RS26425	COG0440	acetolactate synthase activity
RVR_RS26430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RVR_RS26435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RVR_RS26450	COG0506	proline dehydrogenase activity
RVR_RS26460	COG0473	3-isopropylmalate dehydrogenase activity
RVR_RS26465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RVR_RS26470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RVR_RS26480	COG2301	Belongs to the HpcH HpaI aldolase family
RVR_RS26490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RVR_RS26500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RVR_RS26505	COG0179	Fumarylacetoacetate (FAA) hydrolase
RVR_RS26520	COG2018	Roadblock/LC7 domain
RVR_RS26540	COG2018	Roadblock/LC7 domain
RVR_RS26570	COG1414	Transcriptional regulator
RVR_RS26575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RVR_RS26580	COG0066	3-isopropylmalate dehydratase activity
RVR_RS26590	COG0776	regulation of translation
RVR_RS26600	COG1920	GTP binding
RVR_RS26610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RVR_RS26615	COG1181	Belongs to the D-alanine--D-alanine ligase family
RVR_RS26635	COG0351	phosphomethylpyrimidine kinase
RVR_RS26640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RVR_RS26645	COG1461	Dihydroxyacetone kinase
RVR_RS26650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RVR_RS26655	COG0742	ribosomal rna small subunit methyltransferase
RVR_RS26660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RVR_RS26675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RVR_RS26680	COG0571	ribonuclease III activity
RVR_RS26685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RVR_RS26690	COG1733	regulation of RNA biosynthetic process
RVR_RS26695	COG2340	Cysteine-rich secretory protein family
RVR_RS26700	COG1254	Belongs to the acylphosphatase family
RVR_RS26710	COG1196	nuclear chromosome segregation
RVR_RS26715	COG0477	Major facilitator Superfamily
RVR_RS26795	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RVR_RS26820	COG0442	prolyl-tRNA aminoacylation
RVR_RS26830	COG0228	four-way junction DNA binding
RVR_RS26835	COG1837	Belongs to the UPF0109 family
RVR_RS26840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RVR_RS26845	COG0336	Belongs to the RNA methyltransferase TrmD family
RVR_RS26850	COG0335	large ribosomal subunit rRNA binding
RVR_RS26860	COG0681	Belongs to the peptidase S26 family
RVR_RS26865	COG0681	Belongs to the peptidase S26 family
RVR_RS26870	COG0681	Belongs to the peptidase S26 family
RVR_RS26880	COG0792	nuclease activity
RVR_RS26895	COG1191	sigma factor activity
RVR_RS26915	COG0052	Belongs to the universal ribosomal protein uS2 family
RVR_RS26920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RVR_RS26925	COG0528	UMP kinase activity
RVR_RS26930	COG0233	cytoplasmic translational termination
RVR_RS26935	COG0575	Belongs to the CDS family
RVR_RS26940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RVR_RS26950	COG1177	transmembrane transport
RVR_RS26955	COG3842	ATPase activity
RVR_RS26960	COG1611	Belongs to the LOG family
RVR_RS26970	COG1136	(ABC) transporter
RVR_RS26975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RVR_RS26985	COG1012	belongs to the aldehyde dehydrogenase family
RVR_RS26990	COG0584	glycerophosphoryl diester phosphodiesterase
RVR_RS26995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RVR_RS27005	COG3842	ATPase activity
RVR_RS27010	COG1176	ABC-type spermidine putrescine transport system, permease component I
RVR_RS27015	COG1177	transmembrane transport
RVR_RS27020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RVR_RS27055	COG1012	belongs to the aldehyde dehydrogenase family
RVR_RS27065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RVR_RS27070	COG0750	zinc metalloprotease
RVR_RS27075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RVR_RS27105	COG0779	Required for maturation of 30S ribosomal subunits
RVR_RS27120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RVR_RS27130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RVR_RS27135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RVR_RS27165	COG0455	bacterial-type flagellum organization
RVR_RS27175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RVR_RS27180	COG1185	polyribonucleotide nucleotidyltransferase activity
RVR_RS27185	COG0612	Peptidase, M16
RVR_RS27190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RVR_RS27205	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
RVR_RS27210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RVR_RS27215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RVR_RS27245	COG2770	Histidine kinase
RVR_RS27245	COG2208	phosphoserine phosphatase activity
RVR_RS27260	COG1674	ftsk spoiiie
RVR_RS27270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RVR_RS27280	COG1058	Belongs to the CinA family
RVR_RS27280	COG1546	Belongs to the CinA family
RVR_RS27285	COG1396	sequence-specific DNA binding
RVR_RS27290	COG0783	Belongs to the Dps family
RVR_RS27820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RVR_RS27825	COG1201	RNA secondary structure unwinding
RVR_RS27830	COG1917	Cupin 2, conserved barrel domain protein
RVR_RS27830	COG2207	Transcriptional regulator
RVR_RS27855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RVR_RS27870	COG0745	RESPONSE REGULATOR receiver
RVR_RS27875	COG2205	protein histidine kinase activity
RVR_RS27885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RVR_RS27900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RVR_RS27910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RVR_RS27915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RVR_RS27920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RVR_RS27955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RVR_RS27960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RVR_RS27965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RVR_RS27970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RVR_RS27980	COG0588	phosphoglycerate mutase activity
RVR_RS27990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RVR_RS28020	COG1131	(ABC) transporter
RVR_RS28025	COG2186	Transcriptional regulator
RVR_RS28030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RVR_RS28045	COG0187	DNA topoisomerase II activity
RVR_RS28055	COG4585	Histidine kinase
RVR_RS28060	COG2197	response regulator
RVR_RS28070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RVR_RS28080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RVR_RS28085	COG0612	Peptidase, M16
RVR_RS28095	COG1802	Transcriptional regulator
RVR_RS28100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RVR_RS28120	COG1435	thymidine kinase activity
RVR_RS28145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RVR_RS28150	COG0483	inositol monophosphate 1-phosphatase activity
RVR_RS28160	COG0745	RESPONSE REGULATOR receiver
RVR_RS28165	COG2205	protein histidine kinase activity
RVR_RS28190	COG0756	dUTP diphosphatase activity
RVR_RS28200	COG1136	(ABC) transporter
RVR_RS28200	COG4591	ABC-type transport system involved in lipoprotein release permease component
RVR_RS28220	COG0569	domain protein
RVR_RS28225	COG0531	amino acid
RVR_RS28230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RVR_RS28235	COG0477	Major facilitator Superfamily
RVR_RS28250	COG0179	Fumarylacetoacetate (FAA) hydrolase
RVR_RS28260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RVR_RS28270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RVR_RS28275	COG1309	transcriptional regulator
RVR_RS28290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RVR_RS28295	COG0657	acetylesterase activity
RVR_RS28300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RVR_RS28335	COG2040	homocysteine
RVR_RS28340	COG2890	protein-(glutamine-N5) methyltransferase activity
RVR_RS28390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RVR_RS28420	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS28460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RVR_RS28465	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RVR_RS28470	COG1653	transport
RVR_RS28475	COG1175	transmembrane transport
RVR_RS28480	COG0395	ABC-type sugar transport system, permease component
RVR_RS28485	COG1940	carbohydrate kinase activity
RVR_RS28490	COG4213	ABC transporter substrate-binding protein
RVR_RS28500	COG4214	carbohydrate transport
RVR_RS28505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RVR_RS28510	COG0531	amino acid
RVR_RS28520	COG1024	Enoyl-CoA hydratase
RVR_RS28520	COG1250	3-hydroxyacyl-CoA dehydrogenase
RVR_RS28525	COG0183	Belongs to the thiolase family
RVR_RS28545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RVR_RS28550	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RVR_RS28555	COG3253	May function as heme-dependent peroxidase
RVR_RS28565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RVR_RS28570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RVR_RS28575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RVR_RS28595	COG2326	polyphosphate kinase activity
RVR_RS28615	COG0596	Alpha beta hydrolase
RVR_RS28620	COG3903	Transcriptional regulator
RVR_RS28620	COG3629	intracellular signal transduction
RVR_RS28640	COG5002	protein histidine kinase activity
RVR_RS28640	COG2176	DNA-directed DNA polymerase activity
RVR_RS28655	COG2409	Drug exporters of the RND superfamily
RVR_RS28670	COG1116	anion transmembrane transporter activity
RVR_RS28670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RVR_RS28690	COG0529	Catalyzes the synthesis of activated sulfate
RVR_RS28695	COG0175	sulfate reduction
RVR_RS28715	COG1960	acyl-CoA dehydrogenase activity
RVR_RS28750	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RVR_RS28755	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RVR_RS28760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RVR_RS28775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RVR_RS28780	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS28795	COG5441	Belongs to the UPF0261 family
RVR_RS28800	COG5564	TIM-barrel signal transduction protein
RVR_RS28825	COG0038	chloride channel
RVR_RS28840	COG0596	Alpha beta hydrolase
RVR_RS28850	COG0488	(ABC) transporter
RVR_RS28860	COG2226	methyltransferase
RVR_RS28865	COG0671	phosphoesterase, PA-phosphatase related
RVR_RS28875	COG0789	Transcriptional regulator
RVR_RS28895	COG1162	GTPase activity
RVR_RS28925	COG0028	Belongs to the TPP enzyme family
RVR_RS28950	COG0367	asparagine synthase
RVR_RS28970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RVR_RS28985	COG3835	regulator
RVR_RS29000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RVR_RS29045	COG2197	response regulator
RVR_RS29050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RVR_RS29055	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS29080	COG2351	hydroxyisourate hydrolase activity
RVR_RS29095	COG0456	acetyltransferase
RVR_RS29100	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RVR_RS29120	COG1414	Transcriptional regulator
RVR_RS29125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RVR_RS29130	COG2723	6-phospho-beta-galactosidase activity
RVR_RS29135	COG0395	ABC-type sugar transport system, permease component
RVR_RS29140	COG1175	transmembrane transport
RVR_RS29150	COG1940	carbohydrate kinase activity
RVR_RS29160	COG0800	Aldolase
RVR_RS29165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RVR_RS29170	COG3962	Belongs to the TPP enzyme family
RVR_RS29175	COG3718	enzyme involved in inositol metabolism
RVR_RS29205	COG1129	ABC transporter
RVR_RS29210	COG1940	carbohydrate kinase activity
RVR_RS29220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RVR_RS29225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RVR_RS29240	COG3958	Transketolase
RVR_RS29265	COG1335	isochorismatase
RVR_RS29270	COG0477	Major facilitator Superfamily
RVR_RS29290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RVR_RS29295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RVR_RS29300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS29310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RVR_RS29325	COG3618	amidohydrolase
RVR_RS29350	COG0483	inositol monophosphate 1-phosphatase activity
RVR_RS29385	COG1929	Belongs to the glycerate kinase type-1 family
RVR_RS29395	COG0688	phosphatidylethanolamine metabolic process
RVR_RS29400	COG1960	acyl-CoA dehydrogenase activity
RVR_RS29410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RVR_RS29410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RVR_RS29445	COG2814	Major facilitator Superfamily
RVR_RS29455	COG2362	D-Aminopeptidase
RVR_RS29460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RVR_RS29470	COG1619	proteins homologs of microcin C7 resistance protein MccF
RVR_RS29475	COG2814	Major facilitator Superfamily
RVR_RS29485	COG2205	protein histidine kinase activity
RVR_RS29490	COG0745	RESPONSE REGULATOR receiver
RVR_RS29620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RVR_RS29660	COG2304	oxidoreductase activity
RVR_RS29680	COG1484	DNA-dependent DNA replication
RVR_RS30175	COG4266	Belongs to the allantoicase family
RVR_RS30200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RVR_RS30265	COG0583	DNA-binding transcription factor activity
RVR_RS30275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RVR_RS30280	COG1605	Chorismate mutase
RVR_RS30280	COG0287	Prephenate dehydrogenase
RVR_RS30305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RVR_RS30345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RVR_RS30360	COG1073	alpha beta
RVR_RS30365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RVR_RS30370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RVR_RS30390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RVR_RS30395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RVR_RS30410	COG1121	(ABC) transporter
RVR_RS30415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RVR_RS30440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RVR_RS30450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RVR_RS30460	COG1959	2 iron, 2 sulfur cluster binding
RVR_RS30475	COG0601	transmembrane transport
RVR_RS30480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS30495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS30500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RVR_RS30510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RVR_RS30515	COG0583	DNA-binding transcription factor activity
RVR_RS30525	COG1472	Belongs to the glycosyl hydrolase 3 family
RVR_RS30540	COG0019	diaminopimelate decarboxylase activity
RVR_RS30600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RVR_RS30615	COG0546	phosphoglycolate phosphatase activity
RVR_RS30620	COG0488	(ABC) transporter
RVR_RS30625	COG0667	Aldo Keto reductase
RVR_RS30630	COG2207	Transcriptional regulator
RVR_RS30650	COG1024	Enoyl-CoA hydratase
RVR_RS30660	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RVR_RS30680	COG0371	Dehydrogenase
RVR_RS30700	COG1134	teichoic acid transport
RVR_RS30705	COG1562	ergosterol biosynthetic process
RVR_RS30715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RVR_RS30725	COG1657	PFAM Prenyltransferase squalene oxidase
RVR_RS30755	COG2755	lipolytic protein G-D-S-L family
RVR_RS30780	COG3268	Saccharopine dehydrogenase
RVR_RS30800	COG0456	acetyltransferase
RVR_RS30815	COG2186	Transcriptional regulator
RVR_RS30830	COG1366	Belongs to the anti-sigma-factor antagonist family
RVR_RS30830	COG2172	sigma factor antagonist activity
RVR_RS30830	COG2208	phosphoserine phosphatase activity
RVR_RS30835	COG1116	anion transmembrane transporter activity
RVR_RS30850	COG2159	amidohydrolase
RVR_RS30855	COG0028	Belongs to the TPP enzyme family
RVR_RS30895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RVR_RS30915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RVR_RS30950	COG2159	amidohydrolase
RVR_RS30960	COG1301	dicarboxylic acid transport
RVR_RS30975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RVR_RS30980	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS30995	COG3321	synthase
RVR_RS30995	COG0604	alcohol dehydrogenase
RVR_RS31040	COG1063	alcohol dehydrogenase
RVR_RS31045	COG0657	acetylesterase activity
RVR_RS31060	COG2197	response regulator
RVR_RS31075	COG3842	ATPase activity
RVR_RS31080	COG0006	proline dipeptidase activity
RVR_RS31090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RVR_RS31110	COG1802	Transcriptional regulator
RVR_RS31125	COG1819	glycosyl
RVR_RS31135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RVR_RS31140	COG0142	geranyltranstransferase activity
RVR_RS31155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RVR_RS31165	COG2175	clavaminate synthase activity
RVR_RS31170	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS31215	COG0183	Belongs to the thiolase family
RVR_RS31225	COG0492	ferredoxin-NADP+ reductase activity
RVR_RS31235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RVR_RS31290	COG0778	Nitroreductase
RVR_RS31295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RVR_RS31305	COG2159	amidohydrolase
RVR_RS31310	COG2030	dehydratase
RVR_RS31315	COG1024	Enoyl-CoA hydratase
RVR_RS31320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RVR_RS31325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RVR_RS31335	COG0583	DNA-binding transcription factor activity
RVR_RS31340	COG3384	dioxygenase
RVR_RS31345	COG0667	Aldo Keto reductase
RVR_RS31350	COG0492	ferredoxin-NADP+ reductase activity
RVR_RS31365	COG0667	Aldo Keto reductase
RVR_RS31400	COG2272	Belongs to the type-B carboxylesterase lipase family
RVR_RS31405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RVR_RS31420	COG1024	Enoyl-CoA hydratase
RVR_RS31445	COG0604	alcohol dehydrogenase
RVR_RS31445	COG3321	synthase
RVR_RS31475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RVR_RS31490	COG0604	alcohol dehydrogenase
RVR_RS31490	COG3321	synthase
RVR_RS31495	COG0604	alcohol dehydrogenase
RVR_RS31495	COG3321	synthase
RVR_RS31585	COG1175	transmembrane transport
RVR_RS31590	COG0395	ABC-type sugar transport system, permease component
RVR_RS31600	COG3401	FG-GAP repeat protein
RVR_RS31635	COG0745	RESPONSE REGULATOR receiver
RVR_RS31660	COG1522	sequence-specific DNA binding
RVR_RS31665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RVR_RS31670	COG0028	Belongs to the TPP enzyme family
RVR_RS31680	COG1309	transcriptional regulator
RVR_RS31685	COG2267	carboxylic ester hydrolase activity
RVR_RS31690	COG2301	Belongs to the HpcH HpaI aldolase family
RVR_RS31715	COG1414	Transcriptional regulator
RVR_RS31720	COG1960	acyl-CoA dehydrogenase activity
RVR_RS31775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS31800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS31805	COG0601	transmembrane transport
RVR_RS31810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS31830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RVR_RS31850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RVR_RS31880	COG3321	synthase
RVR_RS31880	COG0604	alcohol dehydrogenase
RVR_RS31885	COG0446	pyridine nucleotide-disulphide oxidoreductase
RVR_RS31890	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS31895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RVR_RS31905	COG4172	Belongs to the ABC transporter superfamily
RVR_RS31910	COG0747	negative chemotaxis
RVR_RS31915	COG0601	transmembrane transport
RVR_RS31920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS31940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS31955	COG2801	Transposase and inactivated derivatives
RVR_RS31975	COG0789	Transcriptional regulator
RVR_RS31980	COG3959	Transketolase, thiamine diphosphate binding domain
RVR_RS31985	COG3958	Transketolase
RVR_RS32005	COG3250	beta-galactosidase activity
RVR_RS32010	COG1501	Belongs to the glycosyl hydrolase 31 family
RVR_RS32015	COG4952	isomerase
RVR_RS32035	COG1172	Belongs to the binding-protein-dependent transport system permease family
RVR_RS32040	COG1172	Belongs to the binding-protein-dependent transport system permease family
RVR_RS32045	COG1129	ABC transporter
RVR_RS32095	COG2364	Membrane
RVR_RS32150	COG1472	Belongs to the glycosyl hydrolase 3 family
RVR_RS32160	COG0702	epimerase
RVR_RS32185	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS32200	COG2318	DinB family
RVR_RS32205	COG2095	MarC family integral membrane protein
RVR_RS32215	COG2755	lipolytic protein G-D-S-L family
RVR_RS32215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RVR_RS32240	COG1349	DNA-binding transcription factor activity
RVR_RS32260	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RVR_RS32270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RVR_RS32275	COG2376	Dihydroxyacetone kinase
RVR_RS32280	COG1461	Dihydroxyacetone kinase
RVR_RS32285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RVR_RS32285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RVR_RS32290	COG1376	ErfK ybiS ycfS ynhG family protein
RVR_RS32295	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RVR_RS32300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RVR_RS32305	COG1278	Cold shock
RVR_RS32325	COG1446	asparaginase
RVR_RS32345	COG0475	glutathione-regulated potassium exporter activity
RVR_RS32360	COG0492	ferredoxin-NADP+ reductase activity
RVR_RS32405	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RVR_RS32435	COG0656	L-ascorbic acid biosynthetic process
RVR_RS32440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RVR_RS32460	COG3835	regulator
RVR_RS32465	COG0395	ABC-type sugar transport system, permease component
RVR_RS32470	COG1175	transmembrane transport
RVR_RS32485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RVR_RS32510	COG1846	Transcriptional regulator
RVR_RS32520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RVR_RS32570	COG1309	transcriptional regulator
RVR_RS32585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RVR_RS32590	COG1024	Enoyl-CoA hydratase
RVR_RS32600	COG1609	Transcriptional regulator
RVR_RS32620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RVR_RS32630	COG0372	Belongs to the citrate synthase family
RVR_RS32635	COG0372	Belongs to the citrate synthase family
RVR_RS32645	COG0501	Belongs to the peptidase M48B family
RVR_RS32670	COG0477	Major facilitator Superfamily
RVR_RS32680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RVR_RS32685	COG0183	Belongs to the thiolase family
RVR_RS32690	COG1024	Enoyl-CoA hydratase
RVR_RS32690	COG1250	3-hydroxyacyl-CoA dehydrogenase
RVR_RS32710	COG2183	response to ionizing radiation
RVR_RS32730	COG0446	pyridine nucleotide-disulphide oxidoreductase
RVR_RS32745	COG1742	UPF0060 membrane protein
RVR_RS32780	COG0583	DNA-binding transcription factor activity
RVR_RS32790	COG1132	(ABC) transporter
RVR_RS32795	COG1132	(ABC) transporter
RVR_RS32800	COG1970	mechanosensitive ion channel activity
RVR_RS32805	COG1846	Transcriptional regulator
RVR_RS32810	COG1132	(ABC) transporter
RVR_RS32820	COG0492	ferredoxin-NADP+ reductase activity
RVR_RS32825	COG1472	Belongs to the glycosyl hydrolase 3 family
RVR_RS32830	COG0432	Pfam Uncharacterised protein family UPF0047
RVR_RS32835	COG1793	dna ligase
RVR_RS32850	COG1609	Transcriptional regulator
RVR_RS32870	COG4977	sequence-specific DNA binding
RVR_RS32890	COG2706	6-phosphogluconolactonase activity
RVR_RS32910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RVR_RS32915	COG1309	transcriptional regulator
RVR_RS32945	COG0765	amino acid transport
RVR_RS32955	COG0584	glycerophosphoryl diester phosphodiesterase
RVR_RS33000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RVR_RS33020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RVR_RS33030	COG1940	carbohydrate kinase activity
RVR_RS33035	COG0738	Major facilitator superfamily
RVR_RS33065	COG1660	Displays ATPase and GTPase activities
RVR_RS33095	COG0596	Alpha beta hydrolase
RVR_RS33120	COG1349	DNA-binding transcription factor activity
RVR_RS33145	COG1215	transferase activity, transferring glycosyl groups
RVR_RS33150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RVR_RS33165	COG1051	belongs to the nudix hydrolase family
RVR_RS33180	COG1461	Dihydroxyacetone kinase
RVR_RS33185	COG2376	Dihydroxyacetone kinase
RVR_RS33200	COG2197	response regulator
RVR_RS33215	COG0456	acetyltransferase
RVR_RS33215	COG1846	Transcriptional regulator
RVR_RS33220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RVR_RS33230	COG4977	sequence-specific DNA binding
RVR_RS33235	COG3547	Transposase (IS116 IS110 IS902 family)
RVR_RS33255	COG1396	sequence-specific DNA binding
RVR_RS33260	COG3135	benzoate transporter
RVR_RS33265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RVR_RS33270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RVR_RS33280	COG2815	serine threonine protein kinase
RVR_RS33280	COG0515	serine threonine protein kinase
RVR_RS33285	COG3896	Chloramphenicol phosphotransferase-like protein
RVR_RS33305	COG1335	isochorismatase
RVR_RS33320	COG0259	pyridoxamine-phosphate oxidase activity
RVR_RS33345	COG0510	thiamine kinase activity
RVR_RS33385	COG1984	allophanate hydrolase subunit 2
RVR_RS33390	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RVR_RS33395	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RVR_RS33425	COG2018	Roadblock/LC7 domain
RVR_RS33475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RVR_RS33485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RVR_RS33515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RVR_RS33535	COG1716	ATPase activity
RVR_RS33555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RVR_RS33565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RVR_RS33565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RVR_RS33590	COG0384	phenazine biosynthesis protein PhzF
RVR_RS33620	COG1609	Transcriptional regulator
RVR_RS33635	COG0697	spore germination
RVR_RS33660	COG0697	spore germination
RVR_RS33695	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS33700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RVR_RS33715	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RVR_RS33725	COG0588	phosphoglycerate mutase activity
RVR_RS33745	COG1132	(ABC) transporter
RVR_RS33750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS33755	COG0456	acetyltransferase
RVR_RS33765	COG1126	abc transporter atp-binding protein
RVR_RS33770	COG0765	amino acid transport
RVR_RS33775	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RVR_RS33780	COG1793	dna ligase
RVR_RS33780	COG3285	dna ligase
RVR_RS33800	COG0667	Aldo Keto reductase
RVR_RS33815	COG1733	regulation of RNA biosynthetic process
RVR_RS33825	COG3537	Alpha-1,2-mannosidase
RVR_RS33835	COG3537	Alpha-1,2-mannosidase
RVR_RS33860	COG0154	amidase activity
RVR_RS33865	COG2188	Transcriptional regulator
RVR_RS33880	COG0009	L-threonylcarbamoyladenylate synthase
RVR_RS33965	COG2197	response regulator
RVR_RS33995	COG0579	oxidoreductase
RVR_RS34000	COG1509	lysine 2,3-aminomutase activity
RVR_RS34005	COG0697	spore germination
RVR_RS34010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RVR_RS34015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RVR_RS34030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RVR_RS34035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RVR_RS34055	COG2264	protein methyltransferase activity
RVR_RS34070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RVR_RS34080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RVR_RS34100	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS34115	COG1672	PFAM Archaeal ATPase
RVR_RS34115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RVR_RS34140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RVR_RS34165	COG1024	Enoyl-CoA hydratase
RVR_RS34170	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS34200	COG2192	nodulation
RVR_RS34205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RVR_RS34225	COG0142	geranyltranstransferase activity
RVR_RS34230	COG0494	nUDIX hydrolase
RVR_RS34250	COG2205	protein histidine kinase activity
RVR_RS34250	COG0784	Response regulator, receiver
RVR_RS34275	COG1175	transmembrane transport
RVR_RS34280	COG3842	ATPase activity
RVR_RS34285	COG4134	Bacterial extracellular solute-binding protein
RVR_RS34295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RVR_RS34300	COG1802	Transcriptional regulator
RVR_RS34310	COG0596	Alpha beta hydrolase
RVR_RS34320	COG2197	response regulator
RVR_RS34395	COG4585	Histidine kinase
RVR_RS34400	COG2197	response regulator
RVR_RS34440	COG1595	DNA-templated transcription, initiation
RVR_RS34450	COG0667	Aldo Keto reductase
RVR_RS34460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RVR_RS34465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RVR_RS34470	COG1132	(ABC) transporter
RVR_RS34475	COG1132	(ABC) transporter
RVR_RS34525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RVR_RS34545	COG3251	PFAM MbtH domain protein
RVR_RS34555	COG0515	serine threonine protein kinase
RVR_RS34560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RVR_RS34680	COG4249	Peptidase C14 caspase catalytic subunit p20
RVR_RS34680	COG2319	Wd-40 repeat
RVR_RS34760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS34800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS34805	COG1960	acyl-CoA dehydrogenase activity
RVR_RS34810	COG0667	Aldo Keto reductase
RVR_RS34815	COG0667	Aldo Keto reductase
RVR_RS34825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RVR_RS34830	COG2072	flavoprotein involved in K transport
RVR_RS34835	COG0431	NADPH-dependent FMN reductase
RVR_RS34885	COG1012	belongs to the aldehyde dehydrogenase family
RVR_RS34905	COG1940	carbohydrate kinase activity
RVR_RS34905	COG1846	Transcriptional regulator
RVR_RS34945	COG2409	Drug exporters of the RND superfamily
RVR_RS34970	COG2814	Major facilitator Superfamily
RVR_RS34980	COG0697	spore germination
RVR_RS35010	COG1733	regulation of RNA biosynthetic process
RVR_RS35060	COG0673	inositol 2-dehydrogenase activity
RVR_RS35065	COG1940	carbohydrate kinase activity
RVR_RS35075	COG1175	transmembrane transport
RVR_RS35080	COG0395	ABC-type sugar transport system, permease component
RVR_RS35090	COG1486	melibiose metabolic process
RVR_RS35095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RVR_RS35100	COG0395	ABC-type sugar transport system, permease component
RVR_RS35110	COG2182	Extracellular solute-binding protein
RVR_RS35135	COG0300	oxidoreductase activity
RVR_RS35175	COG1063	alcohol dehydrogenase
RVR_RS35180	COG0395	ABC-type sugar transport system, permease component
RVR_RS35205	COG0667	Aldo Keto reductase
RVR_RS35210	COG0667	Aldo Keto reductase
RVR_RS35215	COG1132	(ABC) transporter
RVR_RS35230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RVR_RS35245	COG0586	Pfam SNARE associated Golgi protein
RVR_RS35255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RVR_RS35255	COG1796	DNA polymerase
RVR_RS35270	COG0598	Magnesium transport protein CorA
RVR_RS35315	COG1609	Transcriptional regulator
RVR_RS35340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RVR_RS35350	COG0789	Transcriptional regulator
RVR_RS35365	COG1522	sequence-specific DNA binding
RVR_RS35385	COG1063	alcohol dehydrogenase
RVR_RS35395	COG0494	nUDIX hydrolase
RVR_RS35400	COG4948	Mandelate Racemase Muconate Lactonizing
RVR_RS35415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS35420	COG0601	transmembrane transport
RVR_RS35430	COG0655	NAD(P)H dehydrogenase (quinone) activity
RVR_RS35440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RVR_RS35465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RVR_RS35475	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
RVR_RS35485	COG1309	transcriptional regulator
RVR_RS35495	COG3321	synthase
RVR_RS35495	COG4221	oxidoreductase activity
RVR_RS35495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RVR_RS35495	COG0604	alcohol dehydrogenase
RVR_RS35500	COG1733	regulation of RNA biosynthetic process
RVR_RS35505	COG1609	Transcriptional regulator
RVR_RS35520	COG2160	L-arabinose isomerase activity
RVR_RS35530	COG1129	ABC transporter
RVR_RS35545	COG2814	Major facilitator Superfamily
RVR_RS35570	COG2971	BadF BadG BcrA BcrD
RVR_RS35595	COG2188	Transcriptional regulator
RVR_RS35600	COG0673	inositol 2-dehydrogenase activity
RVR_RS35605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RVR_RS35620	COG0747	negative chemotaxis
RVR_RS35625	COG4608	Belongs to the ABC transporter superfamily
RVR_RS35630	COG0444	Belongs to the ABC transporter superfamily
RVR_RS35635	COG0601	transmembrane transport
RVR_RS35640	COG1063	alcohol dehydrogenase
RVR_RS35645	COG2188	Transcriptional regulator
RVR_RS35650	COG2409	Drug exporters of the RND superfamily
RVR_RS35765	COG0604	alcohol dehydrogenase
RVR_RS35765	COG3321	synthase
RVR_RS35845	COG1250	3-hydroxyacyl-CoA dehydrogenase
RVR_RS35855	COG1960	acyl-CoA dehydrogenase activity
RVR_RS35965	COG0671	phosphoesterase, PA-phosphatase related
RVR_RS35970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RVR_RS36000	COG1278	Cold shock
RVR_RS36015	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RVR_RS36070	COG0604	alcohol dehydrogenase
RVR_RS36070	COG3321	synthase
RVR_RS36090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RVR_RS36140	COG1674	ftsk spoiiie
RVR_RS36160	COG0464	growth
RVR_RS36215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RVR_RS36220	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RVR_RS36225	COG1120	ATPase activity
RVR_RS36255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RVR_RS36255	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS36255	COG0300	oxidoreductase activity
RVR_RS36255	COG3321	synthase
RVR_RS36255	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS36255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RVR_RS36255	COG1028	Short-chain dehydrogenase reductase Sdr
RVR_RS36255	COG0318	PFAM AMP-dependent synthetase and ligase
RVR_RS36255	COG3321	synthase
RVR_RS36255	COG0300	oxidoreductase activity
RVR_RS36265	COG2226	methyltransferase
RVR_RS36265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RVR_RS36265	COG3433	isochorismatase activity
RVR_RS36350	COG0601	transmembrane transport
RVR_RS36355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RVR_RS36505	COG0741	lytic transglycosylase activity
RVR_RS36650	COG0305	Participates in initiation and elongation during chromosome replication
RVR_RS36655	COG2188	Transcriptional regulator
RVR_RS36815	COG0592	DNA-directed DNA polymerase activity
RVR_RS36870	COG1192	Involved in chromosome partitioning
RVR_RS37025	COG2376	Dihydroxyacetone kinase
RVR_RS37060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RVR_RS37215	COG1660	Displays ATPase and GTPase activities