locus-tag	class	description
E5N77_RS00155	COG0604	alcohol dehydrogenase
E5N77_RS00160	COG1902	pentaerythritol trinitrate reductase activity
E5N77_RS00175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5N77_RS00225	COG0477	Major facilitator Superfamily
E5N77_RS00245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5N77_RS00300	COG3033	Beta-eliminating lyase
E5N77_RS00315	COG2207	Transcriptional regulator
E5N77_RS00335	COG2272	Belongs to the type-B carboxylesterase lipase family
E5N77_RS00375	COG3046	protein related to deoxyribodipyrimidine photolyase
E5N77_RS00380	COG0142	geranyltranstransferase activity
E5N77_RS00400	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E5N77_RS00405	COG2226	methyltransferase
E5N77_RS00415	COG0300	oxidoreductase activity
E5N77_RS00470	COG0516	GMP reductase activity
E5N77_RS00470	COG0517	IMP dehydrogenase activity
E5N77_RS00475	COG1063	alcohol dehydrogenase
E5N77_RS00510	COG0589	response to stress
E5N77_RS00545	COG2197	response regulator
E5N77_RS00550	COG4585	Histidine kinase
E5N77_RS00580	COG0149	triose-phosphate isomerase activity
E5N77_RS00665	COG0517	IMP dehydrogenase activity
E5N77_RS00675	COG1063	alcohol dehydrogenase
E5N77_RS00695	COG0517	IMP dehydrogenase activity
E5N77_RS00700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5N77_RS00700	COG0045	succinate-CoA ligase (ADP-forming) activity
E5N77_RS00700	COG1042	CoA-binding domain protein
E5N77_RS00740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5N77_RS00750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5N77_RS00765	COG0574	Belongs to the PEP-utilizing enzyme family
E5N77_RS00765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5N77_RS00775	COG0516	GMP reductase activity
E5N77_RS00775	COG0517	IMP dehydrogenase activity
E5N77_RS00780	COG1454	alcohol dehydrogenase
E5N77_RS00780	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS00790	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E5N77_RS00815	COG2985	domain, Protein
E5N77_RS00815	COG0490	domain, Protein
E5N77_RS00860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5N77_RS00885	COG0655	NAD(P)H dehydrogenase (quinone) activity
E5N77_RS00910	COG2226	methyltransferase
E5N77_RS00935	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS00940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5N77_RS00945	COG2151	metal-sulfur cluster biosynthetic enzyme
E5N77_RS00950	COG3396	Phenylacetate-CoA oxygenase
E5N77_RS00960	COG3396	Phenylacetate-CoA oxygenase
E5N77_RS00985	COG0604	alcohol dehydrogenase
E5N77_RS01000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5N77_RS01005	COG1595	DNA-templated transcription, initiation
E5N77_RS01050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5N77_RS01060	COG3959	Transketolase, thiamine diphosphate binding domain
E5N77_RS01125	COG0604	alcohol dehydrogenase
E5N77_RS01125	COG3321	synthase
E5N77_RS01140	COG3321	synthase
E5N77_RS01140	COG0604	alcohol dehydrogenase
E5N77_RS01180	COG3321	synthase
E5N77_RS01180	COG0604	alcohol dehydrogenase
E5N77_RS01195	COG3321	synthase
E5N77_RS01195	COG0604	alcohol dehydrogenase
E5N77_RS01220	COG0604	alcohol dehydrogenase
E5N77_RS01220	COG3321	synthase
E5N77_RS01250	COG2124	cytochrome p450
E5N77_RS01260	COG0142	geranyltranstransferase activity
E5N77_RS01280	COG2208	phosphoserine phosphatase activity
E5N77_RS01280	COG2770	Histidine kinase
E5N77_RS01285	COG0596	Alpha beta hydrolase
E5N77_RS01290	COG3321	synthase
E5N77_RS01290	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS01290	COG0604	alcohol dehydrogenase
E5N77_RS01325	COG0702	epimerase
E5N77_RS01330	COG2267	carboxylic ester hydrolase activity
E5N77_RS01340	COG1309	transcriptional regulator
E5N77_RS01355	COG3631	Ketosteroid isomerase-related protein
E5N77_RS01360	COG0702	epimerase
E5N77_RS01365	COG2409	Drug exporters of the RND superfamily
E5N77_RS01370	COG2197	response regulator
E5N77_RS01380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5N77_RS01410	COG2353	YceI-like domain
E5N77_RS01415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5N77_RS01420	COG2318	DinB family
E5N77_RS01430	COG4152	abc transporter atp-binding protein
E5N77_RS01435	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS01455	COG0842	Transport permease protein
E5N77_RS01455	COG1129	ABC transporter
E5N77_RS01500	COG0494	nUDIX hydrolase
E5N77_RS01515	COG0702	epimerase
E5N77_RS01535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5N77_RS01565	COG1231	oxidoreductase activity
E5N77_RS01570	COG2132	Multicopper oxidase
E5N77_RS01585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E5N77_RS01650	COG0542	response to heat
E5N77_RS01670	COG0395	ABC-type sugar transport system, permease component
E5N77_RS01735	COG2186	Transcriptional regulator
E5N77_RS01750	COG2188	Transcriptional regulator
E5N77_RS01780	COG0745	RESPONSE REGULATOR receiver
E5N77_RS01800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5N77_RS01800	COG1116	anion transmembrane transporter activity
E5N77_RS01805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5N77_RS01815	COG0431	NADPH-dependent FMN reductase
E5N77_RS01825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5N77_RS01830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5N77_RS01840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5N77_RS01845	COG1126	abc transporter atp-binding protein
E5N77_RS01850	COG0765	amino acid transport
E5N77_RS01865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5N77_RS01870	COG0765	amino acid transport
E5N77_RS01890	COG0488	(ABC) transporter
E5N77_RS01895	COG0798	PFAM Bile acid sodium symporter
E5N77_RS01900	COG0640	Transcriptional regulator
E5N77_RS01905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5N77_RS01940	COG2226	methyltransferase
E5N77_RS01960	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5N77_RS01995	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5N77_RS02005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5N77_RS02010	COG1120	ATPase activity
E5N77_RS02030	COG0531	amino acid
E5N77_RS02075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5N77_RS02090	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5N77_RS02125	COG1366	Belongs to the anti-sigma-factor antagonist family
E5N77_RS02130	COG1366	Belongs to the anti-sigma-factor antagonist family
E5N77_RS02135	COG2172	sigma factor antagonist activity
E5N77_RS02150	COG0667	Aldo Keto reductase
E5N77_RS02155	COG1733	regulation of RNA biosynthetic process
E5N77_RS02175	COG0477	Major facilitator Superfamily
E5N77_RS02185	COG4191	Histidine kinase
E5N77_RS02205	COG2072	flavoprotein involved in K transport
E5N77_RS02230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS02235	COG1120	ATPase activity
E5N77_RS02245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5N77_RS02250	COG0583	DNA-binding transcription factor activity
E5N77_RS02255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5N77_RS02265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5N77_RS02280	COG4709	membrane
E5N77_RS02300	COG2814	Major facilitator Superfamily
E5N77_RS02310	COG1609	Transcriptional regulator
E5N77_RS02315	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E5N77_RS02320	COG0659	secondary active sulfate transmembrane transporter activity
E5N77_RS02325	COG0789	Transcriptional regulator
E5N77_RS02405	COG1309	transcriptional regulator
E5N77_RS02460	COG2755	lipolytic protein G-D-S-L family
E5N77_RS02460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5N77_RS02470	COG0666	response to abiotic stimulus
E5N77_RS02475	COG2208	phosphoserine phosphatase activity
E5N77_RS02525	COG1733	regulation of RNA biosynthetic process
E5N77_RS02545	COG0596	Alpha beta hydrolase
E5N77_RS02570	COG4941	Belongs to the sigma-70 factor family
E5N77_RS02575	COG3795	YCII-related domain
E5N77_RS02590	COG1733	regulation of RNA biosynthetic process
E5N77_RS02610	COG2353	YceI-like domain
E5N77_RS02640	COG0154	amidase activity
E5N77_RS02645	COG1309	transcriptional regulator
E5N77_RS02670	COG0346	lactoylglutathione lyase activity
E5N77_RS02725	COG0395	ABC-type sugar transport system, permease component
E5N77_RS02765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5N77_RS02770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5N77_RS02790	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E5N77_RS02805	COG2239	Acts as a magnesium transporter
E5N77_RS02860	COG3226	Transcriptional regulator
E5N77_RS02865	COG2391	methyltransferase activity
E5N77_RS02870	COG0326	Molecular chaperone. Has ATPase activity
E5N77_RS02885	COG2755	lipolytic protein G-D-S-L family
E5N77_RS02890	COG4977	sequence-specific DNA binding
E5N77_RS02935	COG2175	clavaminate synthase activity
E5N77_RS02945	COG0395	ABC-type sugar transport system, permease component
E5N77_RS02950	COG1175	transmembrane transport
E5N77_RS02970	COG1953	Uracil, thiamine, allantoin
E5N77_RS02995	COG3795	YCII-related domain
E5N77_RS03000	COG4941	Belongs to the sigma-70 factor family
E5N77_RS03015	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS03040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5N77_RS03045	COG2151	metal-sulfur cluster biosynthetic enzyme
E5N77_RS03050	COG3396	Phenylacetate-CoA oxygenase
E5N77_RS03055	COG3460	Phenylacetate-CoA oxygenase
E5N77_RS03060	COG3396	Phenylacetate-CoA oxygenase
E5N77_RS03065	COG2050	protein possibly involved in aromatic compounds catabolism
E5N77_RS03115	COG5640	endopeptidase activity
E5N77_RS03120	COG1119	ATPase activity
E5N77_RS03135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5N77_RS03145	COG1335	isochorismatase
E5N77_RS03210	COG0583	DNA-binding transcription factor activity
E5N77_RS03215	COG2124	cytochrome p450
E5N77_RS03235	COG3340	Belongs to the peptidase S51 family
E5N77_RS03245	COG0583	DNA-binding transcription factor activity
E5N77_RS03260	COG2814	Major facilitator Superfamily
E5N77_RS03270	COG0583	DNA-binding transcription factor activity
E5N77_RS03275	COG5640	endopeptidase activity
E5N77_RS03295	COG1017	nitric oxide dioxygenase activity
E5N77_RS03295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5N77_RS03300	COG1959	2 iron, 2 sulfur cluster binding
E5N77_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS03360	COG0028	Belongs to the TPP enzyme family
E5N77_RS03370	COG4209	transmembrane transport
E5N77_RS03375	COG0395	ABC-type sugar transport system, permease component
E5N77_RS03395	COG0110	maltose O-acetyltransferase activity
E5N77_RS03415	COG1120	ATPase activity
E5N77_RS03490	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E5N77_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS03520	COG0475	glutathione-regulated potassium exporter activity
E5N77_RS03540	COG1131	(ABC) transporter
E5N77_RS03545	COG0142	geranyltranstransferase activity
E5N77_RS03555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5N77_RS03560	COG2124	cytochrome p450
E5N77_RS03565	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5N77_RS03605	COG0456	acetyltransferase
E5N77_RS03610	COG0243	molybdopterin cofactor binding
E5N77_RS03670	COG0753	catalase activity
E5N77_RS03700	COG0009	L-threonylcarbamoyladenylate synthase
E5N77_RS03745	COG1793	dna ligase
E5N77_RS03745	COG3285	dna ligase
E5N77_RS03765	COG1191	sigma factor activity
E5N77_RS03810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5N77_RS03815	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E5N77_RS03845	COG2205	protein histidine kinase activity
E5N77_RS03845	COG0784	Response regulator, receiver
E5N77_RS03845	COG5002	protein histidine kinase activity
E5N77_RS03860	COG1366	Belongs to the anti-sigma-factor antagonist family
E5N77_RS03865	COG1366	Belongs to the anti-sigma-factor antagonist family
E5N77_RS03870	COG2172	sigma factor antagonist activity
E5N77_RS03925	COG1982	Orn Lys Arg decarboxylase major
E5N77_RS03980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5N77_RS04010	COG2197	response regulator
E5N77_RS04015	COG2340	Cysteine-rich secretory protein family
E5N77_RS04025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5N77_RS04030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5N77_RS04030	COG0515	serine threonine protein kinase
E5N77_RS04035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5N77_RS04055	COG0667	Aldo Keto reductase
E5N77_RS04065	COG0328	RNA-DNA hybrid ribonuclease activity
E5N77_RS04080	COG0740	serine-type endopeptidase activity
E5N77_RS04085	COG0740	serine-type endopeptidase activity
E5N77_RS04090	COG1396	sequence-specific DNA binding
E5N77_RS04095	COG1191	sigma factor activity
E5N77_RS04125	COG0667	Aldo Keto reductase
E5N77_RS04130	COG0583	DNA-binding transcription factor activity
E5N77_RS04140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5N77_RS04145	COG0346	lactoylglutathione lyase activity
E5N77_RS04155	COG0667	Aldo Keto reductase
E5N77_RS04165	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS04215	COG0673	inositol 2-dehydrogenase activity
E5N77_RS04255	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS04260	COG2366	antibiotic biosynthetic process
E5N77_RS04265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E5N77_RS04280	COG0515	serine threonine protein kinase
E5N77_RS04310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5N77_RS04320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5N77_RS04325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5N77_RS04340	COG2205	protein histidine kinase activity
E5N77_RS04345	COG0745	RESPONSE REGULATOR receiver
E5N77_RS04375	COG0154	amidase activity
E5N77_RS04390	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E5N77_RS04400	COG0515	serine threonine protein kinase
E5N77_RS04410	COG1959	2 iron, 2 sulfur cluster binding
E5N77_RS04415	COG2326	polyphosphate kinase activity
E5N77_RS04440	COG1132	(ABC) transporter
E5N77_RS04445	COG1132	(ABC) transporter
E5N77_RS04490	COG2175	clavaminate synthase activity
E5N77_RS04500	COG0673	inositol 2-dehydrogenase activity
E5N77_RS04505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5N77_RS04510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5N77_RS04530	COG3173	Aminoglycoside phosphotransferase
E5N77_RS04570	COG2376	Dihydroxyacetone kinase
E5N77_RS04575	COG1461	Dihydroxyacetone kinase
E5N77_RS04580	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E5N77_RS04590	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS04615	COG1902	pentaerythritol trinitrate reductase activity
E5N77_RS04615	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5N77_RS04635	COG2890	protein-(glutamine-N5) methyltransferase activity
E5N77_RS04650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5N77_RS04665	COG3458	cephalosporin-C deacetylase activity
E5N77_RS04670	COG2188	Transcriptional regulator
E5N77_RS04680	COG1695	Transcriptional regulator
E5N77_RS04690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E5N77_RS04700	COG2066	Belongs to the glutaminase family
E5N77_RS04710	COG1968	undecaprenyl-diphosphatase activity
E5N77_RS04730	COG1175	transmembrane transport
E5N77_RS04735	COG0395	ABC-type sugar transport system, permease component
E5N77_RS04745	COG1846	Transcriptional regulator
E5N77_RS04770	COG0137	argininosuccinate synthase activity
E5N77_RS04795	COG1175	transmembrane transport
E5N77_RS04800	COG1653	transport
E5N77_RS04805	COG1609	Transcriptional regulator
E5N77_RS04830	COG1309	transcriptional regulator
E5N77_RS04845	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS04865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5N77_RS04870	COG0463	Glycosyl transferase, family 2
E5N77_RS04905	COG1349	DNA-binding transcription factor activity
E5N77_RS04955	COG1940	carbohydrate kinase activity
E5N77_RS04965	COG2813	Specifically methylates the guanine in position
E5N77_RS04975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5N77_RS05025	COG0783	Belongs to the Dps family
E5N77_RS05040	COG1501	Belongs to the glycosyl hydrolase 31 family
E5N77_RS05050	COG1175	transmembrane transport
E5N77_RS05055	COG0395	ABC-type sugar transport system, permease component
E5N77_RS05060	COG2723	6-phospho-beta-galactosidase activity
E5N77_RS05090	COG2197	response regulator
E5N77_RS05095	COG4585	Histidine kinase
E5N77_RS05105	COG0445	tRNA wobble uridine modification
E5N77_RS05120	COG1660	Displays ATPase and GTPase activities
E5N77_RS05170	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E5N77_RS05190	COG0204	Acyl-transferase
E5N77_RS05215	COG0584	glycerophosphoryl diester phosphodiesterase
E5N77_RS05255	COG0671	phosphoesterase, PA-phosphatase related
E5N77_RS05280	COG0640	Transcriptional regulator
E5N77_RS05285	COG1902	pentaerythritol trinitrate reductase activity
E5N77_RS05300	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS05310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5N77_RS05325	COG2706	6-phosphogluconolactonase activity
E5N77_RS05340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5N77_RS05375	COG4221	oxidoreductase activity
E5N77_RS05385	COG0726	polysaccharide deacetylase
E5N77_RS05395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5N77_RS05400	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5N77_RS05405	COG2080	2 iron, 2 sulfur cluster binding
E5N77_RS05415	COG4565	transcriptional regulatory protein
E5N77_RS05420	COG3290	protein histidine kinase activity
E5N77_RS05455	COG1063	alcohol dehydrogenase
E5N77_RS05465	COG0432	Pfam Uncharacterised protein family UPF0047
E5N77_RS05470	COG2072	flavoprotein involved in K transport
E5N77_RS05480	COG1132	(ABC) transporter
E5N77_RS05495	COG1132	(ABC) transporter
E5N77_RS05500	COG1132	(ABC) transporter
E5N77_RS05510	COG0254	rRNA binding
E5N77_RS05525	COG1946	Acyl-CoA thioesterase
E5N77_RS05530	COG2018	Roadblock/LC7 domain
E5N77_RS05595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5N77_RS05605	COG2115	Belongs to the xylose isomerase family
E5N77_RS05610	COG1070	Carbohydrate kinase
E5N77_RS05615	COG1846	Transcriptional regulator
E5N77_RS05615	COG1940	carbohydrate kinase activity
E5N77_RS05630	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS05635	COG1472	Belongs to the glycosyl hydrolase 3 family
E5N77_RS05645	COG0592	DNA-directed DNA polymerase activity
E5N77_RS05660	COG0714	Associated with various cellular activities
E5N77_RS05710	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS05715	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS05725	COG3800	Transcriptional regulator
E5N77_RS05725	COG1396	sequence-specific DNA binding
E5N77_RS05735	COG1793	dna ligase
E5N77_RS05745	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS05755	COG3424	synthase
E5N77_RS05760	COG2124	cytochrome p450
E5N77_RS05770	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS05780	COG0242	peptide deformylase activity
E5N77_RS05785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5N77_RS05790	COG3442	glutamine amidotransferase
E5N77_RS05795	COG0205	6-phosphofructokinase activity
E5N77_RS05810	COG3275	phosphorelay sensor kinase activity
E5N77_RS05815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5N77_RS05825	COG3279	Response regulator of the LytR AlgR family
E5N77_RS05830	COG1522	sequence-specific DNA binding
E5N77_RS05835	COG1834	amidinotransferase
E5N77_RS05840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5N77_RS05850	COG0477	Major facilitator Superfamily
E5N77_RS05870	COG0829	nickel cation binding
E5N77_RS05875	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E5N77_RS05885	COG0804	urea catabolic process
E5N77_RS05890	COG0832	Belongs to the urease beta subunit family
E5N77_RS05895	COG0831	urea catabolic process
E5N77_RS05900	COG1309	transcriptional regulator
E5N77_RS05915	COG0740	serine-type endopeptidase activity
E5N77_RS05950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5N77_RS05955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E5N77_RS05960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E5N77_RS05965	COG2226	methyltransferase
E5N77_RS05985	COG0456	acetyltransferase
E5N77_RS06005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5N77_RS06010	COG3663	DNA glycosylase
E5N77_RS06025	COG1131	(ABC) transporter
E5N77_RS06030	COG4585	Histidine kinase
E5N77_RS06035	COG2197	response regulator
E5N77_RS06040	COG1940	carbohydrate kinase activity
E5N77_RS06045	COG2188	Transcriptional regulator
E5N77_RS06050	COG1595	DNA-templated transcription, initiation
E5N77_RS06055	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5N77_RS06055	COG0596	Alpha beta hydrolase
E5N77_RS06085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5N77_RS06090	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E5N77_RS06100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E5N77_RS06100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5N77_RS06145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5N77_RS06160	COG0626	cystathionine gamma-synthase activity
E5N77_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS06185	COG1522	sequence-specific DNA binding
E5N77_RS06190	COG0419	ATPase involved in DNA repair
E5N77_RS06195	COG0420	3'-5' exonuclease activity
E5N77_RS06200	COG1739	Uncharacterized protein family UPF0029
E5N77_RS06210	COG1832	CoA-binding protein
E5N77_RS06220	COG0640	Transcriptional regulator
E5N77_RS06240	COG0110	maltose O-acetyltransferase activity
E5N77_RS06290	COG1968	undecaprenyl-diphosphatase activity
E5N77_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS06325	COG2318	DinB family
E5N77_RS06340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5N77_RS06375	COG0723	plastoquinol--plastocyanin reductase activity
E5N77_RS06390	COG0697	spore germination
E5N77_RS06430	COG0384	phenazine biosynthesis protein PhzF
E5N77_RS06455	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E5N77_RS06460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E5N77_RS06465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E5N77_RS06480	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5N77_RS06500	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5N77_RS06500	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5N77_RS06550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5N77_RS06590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5N77_RS06645	COG2018	Roadblock/LC7 domain
E5N77_RS06670	COG1414	Transcriptional regulator
E5N77_RS06685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5N77_RS06715	COG2814	Major facilitator Superfamily
E5N77_RS06720	COG4336	lyase activity
E5N77_RS06725	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E5N77_RS06735	COG1984	allophanate hydrolase subunit 2
E5N77_RS06745	COG0438	transferase activity, transferring glycosyl groups
E5N77_RS06750	COG0438	transferase activity, transferring glycosyl groups
E5N77_RS06785	COG2364	Membrane
E5N77_RS06795	COG2270	Major facilitator Superfamily
E5N77_RS06810	COG1216	Glycosyl transferase, family 2
E5N77_RS06835	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS06885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5N77_RS06890	COG0140	phosphoribosyl-ATP diphosphatase activity
E5N77_RS06895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5N77_RS06900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5N77_RS06900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5N77_RS06905	COG3201	nicotinamide mononucleotide transporter
E5N77_RS06925	COG2223	nitrite transmembrane transporter activity
E5N77_RS06935	COG2233	PERMEase
E5N77_RS06960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5N77_RS06980	COG0531	amino acid
E5N77_RS06995	COG2390	Transcriptional regulator
E5N77_RS07000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5N77_RS07010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5N77_RS07025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5N77_RS07035	COG1758	RNA polymerase activity
E5N77_RS07040	COG0194	GDP metabolic process
E5N77_RS07050	COG0284	orotidine-5'-phosphate decarboxylase activity
E5N77_RS07055	COG0167	dihydroorotate dehydrogenase activity
E5N77_RS07060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5N77_RS07065	COG0505	Belongs to the CarA family
E5N77_RS07075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5N77_RS07080	COG0540	Belongs to the ATCase OTCase family
E5N77_RS07085	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E5N77_RS07095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5N77_RS07100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5N77_RS07105	COG0006	proline dipeptidase activity
E5N77_RS07115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5N77_RS07120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5N77_RS07125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5N77_RS07130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5N77_RS07145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5N77_RS07150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5N77_RS07170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5N77_RS07185	COG0124	histidyl-tRNA synthetase
E5N77_RS07195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5N77_RS07200	COG1196	nuclear chromosome segregation
E5N77_RS07205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5N77_RS07215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5N77_RS07220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5N77_RS07225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5N77_RS07235	COG2255	four-way junction helicase activity
E5N77_RS07240	COG0632	four-way junction helicase activity
E5N77_RS07245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E5N77_RS07250	COG0217	transcriptional regulatory protein
E5N77_RS07255	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E5N77_RS07260	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E5N77_RS07270	COG0438	transferase activity, transferring glycosyl groups
E5N77_RS07275	COG1560	Kdo2-lipid A biosynthetic process
E5N77_RS07280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5N77_RS07300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5N77_RS07315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5N77_RS07340	COG0395	ABC-type sugar transport system, permease component
E5N77_RS07345	COG1175	transmembrane transport
E5N77_RS07400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5N77_RS07460	COG1648	precorrin-2 dehydrogenase activity
E5N77_RS07460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5N77_RS07465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5N77_RS07485	COG2011	ABC-type metal ion transport system permease component
E5N77_RS07490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5N77_RS07515	COG0584	glycerophosphoryl diester phosphodiesterase
E5N77_RS07520	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS07520	COG0204	Acyl-transferase
E5N77_RS07525	COG0477	Major facilitator Superfamily
E5N77_RS07540	COG0165	Argininosuccinate lyase
E5N77_RS07570	COG1438	arginine binding
E5N77_RS07575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5N77_RS07580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5N77_RS07585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5N77_RS07590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5N77_RS07620	COG0697	spore germination
E5N77_RS07630	COG1649	PFAM Uncharacterised BCR, COG1649
E5N77_RS07655	COG0072	phenylalanine-tRNA ligase activity
E5N77_RS07655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5N77_RS07660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5N77_RS07665	COG5002	protein histidine kinase activity
E5N77_RS07670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5N77_RS07675	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5N77_RS07680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5N77_RS07685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5N77_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS07730	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS07735	COG0174	glutamine synthetase
E5N77_RS07745	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5N77_RS07770	COG4176	ABC-type proline glycine betaine transport system permease component
E5N77_RS07775	COG0517	IMP dehydrogenase activity
E5N77_RS07775	COG4175	Glycine betaine
E5N77_RS07780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5N77_RS07795	COG0564	pseudouridine synthase activity
E5N77_RS07830	COG0805	protein transport
E5N77_RS07835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5N77_RS07865	COG0545	Peptidyl-prolyl cis-trans isomerase
E5N77_RS07870	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E5N77_RS07880	COG1609	Transcriptional regulator
E5N77_RS07885	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E5N77_RS07890	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E5N77_RS07905	COG4122	O-methyltransferase activity
E5N77_RS07910	COG1222	aaa ATPase
E5N77_RS07935	COG0517	IMP dehydrogenase activity
E5N77_RS07935	COG1994	Peptidase M50
E5N77_RS07945	COG2197	response regulator
E5N77_RS07950	COG4166	transmembrane transport
E5N77_RS07960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5N77_RS07965	COG1410	methionine synthase
E5N77_RS07965	COG0646	methionine synthase
E5N77_RS07970	COG1414	Transcriptional regulator
E5N77_RS07975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5N77_RS07980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5N77_RS07985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5N77_RS07995	COG0215	cysteine-tRNA ligase activity
E5N77_RS08010	COG0588	phosphoglycerate mutase activity
E5N77_RS08015	COG0598	Magnesium transport protein CorA
E5N77_RS08025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5N77_RS08030	COG0667	Aldo Keto reductase
E5N77_RS08060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5N77_RS08070	COG3012	SEC-C Motif Domain Protein
E5N77_RS08075	COG2186	Transcriptional regulator
E5N77_RS08080	COG3265	gluconokinase activity
E5N77_RS08105	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E5N77_RS08120	COG2149	membrane
E5N77_RS08160	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS08195	COG0789	Transcriptional regulator
E5N77_RS08215	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS08225	COG0640	Transcriptional regulator
E5N77_RS08230	COG0697	spore germination
E5N77_RS08245	COG3842	ATPase activity
E5N77_RS08260	COG2851	Citrate transporter
E5N77_RS08265	COG0243	molybdopterin cofactor binding
E5N77_RS08270	COG1309	transcriptional regulator
E5N77_RS08280	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E5N77_RS08285	COG2188	Transcriptional regulator
E5N77_RS08320	COG1595	DNA-templated transcription, initiation
E5N77_RS08325	COG2815	serine threonine protein kinase
E5N77_RS08325	COG0515	serine threonine protein kinase
E5N77_RS08330	COG2755	lipolytic protein G-D-S-L family
E5N77_RS08335	COG0463	Glycosyl transferase, family 2
E5N77_RS08345	COG1649	PFAM Uncharacterised BCR, COG1649
E5N77_RS08345	COG0726	polysaccharide deacetylase
E5N77_RS08360	COG1725	Transcriptional regulator
E5N77_RS08380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5N77_RS08380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5N77_RS08395	COG0662	Cupin 2, conserved barrel domain protein
E5N77_RS08395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5N77_RS08405	COG0587	DNA-directed DNA polymerase activity
E5N77_RS08430	COG1799	cell septum assembly
E5N77_RS08435	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS08440	COG0477	Major facilitator Superfamily
E5N77_RS08450	COG0671	phosphoesterase, PA-phosphatase related
E5N77_RS08475	COG1160	GTP binding
E5N77_RS08485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5N77_RS08500	COG0723	plastoquinol--plastocyanin reductase activity
E5N77_RS08535	COG1187	pseudouridine synthase activity
E5N77_RS08540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5N77_RS08545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5N77_RS08560	COG0686	Belongs to the AlaDH PNT family
E5N77_RS08570	COG0494	nUDIX hydrolase
E5N77_RS08575	COG0504	CTP synthase activity
E5N77_RS08580	COG3387	PFAM Glycoside hydrolase 15-related
E5N77_RS08590	COG0297	glycogen (starch) synthase activity
E5N77_RS08600	COG0497	DNA recombination
E5N77_RS08605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5N77_RS08625	COG1120	ATPase activity
E5N77_RS08630	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS08635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS08640	COG0647	UMP catabolic process
E5N77_RS08680	COG2094	Belongs to the DNA glycosylase MPG family
E5N77_RS08690	COG1881	PFAM PEBP family protein
E5N77_RS08710	COG1119	ATPase activity
E5N77_RS08725	COG2197	response regulator
E5N77_RS08730	COG4585	Histidine kinase
E5N77_RS08735	COG4221	oxidoreductase activity
E5N77_RS08750	COG1131	(ABC) transporter
E5N77_RS08750	COG0842	Transport permease protein
E5N77_RS08750	COG1716	ATPase activity
E5N77_RS08760	COG3830	Belongs to the UPF0237 family
E5N77_RS08760	COG0560	Phosphoserine phosphatase
E5N77_RS08765	COG0588	phosphoglycerate mutase activity
E5N77_RS08785	COG2186	Transcriptional regulator
E5N77_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS08815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5N77_RS08835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5N77_RS08840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5N77_RS08860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5N77_RS08870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5N77_RS08885	COG3387	PFAM Glycoside hydrolase 15-related
E5N77_RS08925	COG1024	Enoyl-CoA hydratase
E5N77_RS08940	COG0488	(ABC) transporter
E5N77_RS08960	COG0235	Class ii aldolase
E5N77_RS08975	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E5N77_RS08980	COG1492	cobalamin metabolic process
E5N77_RS09000	COG1797	cobyrinic acid a,c-diamide synthase activity
E5N77_RS09035	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
E5N77_RS09065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5N77_RS09070	COG0456	acetyltransferase
E5N77_RS09075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5N77_RS09080	COG1917	Cupin 2, conserved barrel domain protein
E5N77_RS09085	COG5285	phytanoyl-CoA dioxygenase
E5N77_RS09115	COG1414	Transcriptional regulator
E5N77_RS09130	COG4585	Histidine kinase
E5N77_RS09135	COG2197	response regulator
E5N77_RS09145	COG1595	DNA-templated transcription, initiation
E5N77_RS09170	COG4677	pectinesterase activity
E5N77_RS09175	COG3866	Pectate lyase
E5N77_RS09180	COG2755	lipolytic protein G-D-S-L family
E5N77_RS09195	COG3507	Belongs to the glycosyl hydrolase 43 family
E5N77_RS09210	COG0395	ABC-type sugar transport system, permease component
E5N77_RS09230	COG1802	Transcriptional regulator
E5N77_RS09250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5N77_RS09255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5N77_RS09260	COG1349	DNA-binding transcription factor activity
E5N77_RS09280	COG1063	alcohol dehydrogenase
E5N77_RS09295	COG1309	transcriptional regulator
E5N77_RS09305	COG1802	Transcriptional regulator
E5N77_RS09345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5N77_RS09360	COG2171	N-acyltransferase activity
E5N77_RS09365	COG3226	Transcriptional regulator
E5N77_RS09375	COG2151	metal-sulfur cluster biosynthetic enzyme
E5N77_RS09380	COG0822	iron-sulfur transferase activity
E5N77_RS09385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5N77_RS09390	COG0396	ATPase activity
E5N77_RS09400	COG0719	Fe-S assembly protein
E5N77_RS09415	COG2746	aminoglycoside 3-N-acetyltransferase activity
E5N77_RS09420	COG1131	(ABC) transporter
E5N77_RS09445	COG0109	protoheme IX farnesyltransferase activity
E5N77_RS09460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5N77_RS09475	COG0363	glucosamine-6-phosphate deaminase activity
E5N77_RS09485	COG0148	phosphopyruvate hydratase activity
E5N77_RS09490	COG0395	ABC-type sugar transport system, permease component
E5N77_RS09495	COG1175	transmembrane transport
E5N77_RS09500	COG1653	transport
E5N77_RS09505	COG0366	Alpha amylase catalytic
E5N77_RS09510	COG1653	transport
E5N77_RS09515	COG1695	Transcriptional regulator
E5N77_RS09520	COG1136	(ABC) transporter
E5N77_RS09530	COG0166	Belongs to the GPI family
E5N77_RS09540	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5N77_RS09545	COG0149	triose-phosphate isomerase activity
E5N77_RS09550	COG0126	phosphoglycerate kinase activity
E5N77_RS09555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5N77_RS09565	COG1481	regulation of sporulation
E5N77_RS09570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5N77_RS09575	COG1660	Displays ATPase and GTPase activities
E5N77_RS09580	COG0322	excinuclease ABC activity
E5N77_RS09605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5N77_RS09620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E5N77_RS09625	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5N77_RS09630	COG0387	Pfam Sodium calcium exchanger
E5N77_RS09650	COG0556	nucleotide-excision repair
E5N77_RS09660	COG0584	glycerophosphoryl diester phosphodiesterase
E5N77_RS09665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5N77_RS09675	COG2313	pseudouridylate synthase activity
E5N77_RS09685	COG2226	methyltransferase
E5N77_RS09690	COG0598	Magnesium transport protein CorA
E5N77_RS09740	COG0402	S-adenosylhomocysteine deaminase activity
E5N77_RS09760	COG2267	carboxylic ester hydrolase activity
E5N77_RS09775	COG2226	methyltransferase
E5N77_RS09790	COG0237	dephospho-CoA kinase activity
E5N77_RS09800	COG0539	negative regulation of cytoplasmic translation
E5N77_RS09805	COG2226	methyltransferase
E5N77_RS09810	COG1643	Atp-dependent helicase
E5N77_RS09840	COG2050	protein possibly involved in aromatic compounds catabolism
E5N77_RS09900	COG0737	Belongs to the 5'-nucleotidase family
E5N77_RS09920	COG1605	Chorismate mutase
E5N77_RS09920	COG0287	Prephenate dehydrogenase
E5N77_RS09935	COG2304	oxidoreductase activity
E5N77_RS09955	COG0069	glutamate synthase activity
E5N77_RS09955	COG0067	glutamate synthase
E5N77_RS09955	COG0070	glutamate synthase
E5N77_RS09985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5N77_RS09990	COG2301	Belongs to the HpcH HpaI aldolase family
E5N77_RS09995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5N77_RS10005	COG0159	tryptophan synthase activity
E5N77_RS10010	COG0133	tryptophan synthase activity
E5N77_RS10020	COG0134	indole-3-glycerol-phosphate synthase activity
E5N77_RS10045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5N77_RS10060	COG0107	imidazoleglycerol-phosphate synthase activity
E5N77_RS10065	COG0251	oxidation-reduction process
E5N77_RS10070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5N77_RS10075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5N77_RS10080	COG0131	Imidazoleglycerol-phosphate dehydratase
E5N77_RS10085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5N77_RS10090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5N77_RS10110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5N77_RS10130	COG1432	Conserved Protein
E5N77_RS10140	COG0587	DNA-directed DNA polymerase activity
E5N77_RS10190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5N77_RS10200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5N77_RS10205	COG3599	regulation of cell shape
E5N77_RS10215	COG1799	cell septum assembly
E5N77_RS10225	COG1496	oxidoreductase activity
E5N77_RS10230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5N77_RS10235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5N77_RS10240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5N77_RS10250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5N77_RS10255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5N77_RS10265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5N77_RS10270	COG0768	penicillin binding
E5N77_RS10280	COG0275	rRNA processing
E5N77_RS10290	COG0714	Associated with various cellular activities
E5N77_RS10310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5N77_RS10360	COG1129	ABC transporter
E5N77_RS10370	COG1309	transcriptional regulator
E5N77_RS10390	COG0352	thiamine-phosphate diphosphorylase activity
E5N77_RS10410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5N77_RS10410	COG2022	thiamine diphosphate biosynthetic process
E5N77_RS10420	COG2022	thiamine diphosphate biosynthetic process
E5N77_RS10425	COG2815	serine threonine protein kinase
E5N77_RS10425	COG0515	serine threonine protein kinase
E5N77_RS10430	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E5N77_RS10435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5N77_RS10440	COG2193	ferroxidase activity
E5N77_RS10450	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E5N77_RS10465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5N77_RS10470	COG0205	6-phosphofructokinase activity
E5N77_RS10475	COG2197	response regulator
E5N77_RS10480	COG4585	Histidine kinase
E5N77_RS10505	COG1940	carbohydrate kinase activity
E5N77_RS10515	COG0003	Pfam Anion-transporting ATPase
E5N77_RS10535	COG0438	transferase activity, transferring glycosyl groups
E5N77_RS10555	COG0791	NLP P60 protein
E5N77_RS10555	COG3103	Sh3 type 3 domain protein
E5N77_RS10555	COG1388	LysM domain
E5N77_RS10585	COG2205	protein histidine kinase activity
E5N77_RS10590	COG0745	RESPONSE REGULATOR receiver
E5N77_RS10600	COG1929	Belongs to the glycerate kinase type-1 family
E5N77_RS10605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5N77_RS10610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5N77_RS10615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5N77_RS10620	COG0723	plastoquinol--plastocyanin reductase activity
E5N77_RS10625	COG2010	Cytochrome c
E5N77_RS10630	COG1845	cytochrome c oxidase, subunit III
E5N77_RS10640	COG1376	ErfK ybiS ycfS ynhG family protein
E5N77_RS10650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5N77_RS10655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5N77_RS10665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5N77_RS10690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5N77_RS10700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5N77_RS10705	COG2197	response regulator
E5N77_RS10710	COG4585	Histidine kinase
E5N77_RS10730	COG2226	methyltransferase
E5N77_RS10735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5N77_RS10750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5N77_RS10755	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5N77_RS10770	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E5N77_RS10780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5N77_RS10785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5N77_RS10790	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5N77_RS10800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E5N77_RS10820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5N77_RS10845	COG0321	lipoyl(octanoyl) transferase activity
E5N77_RS10850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5N77_RS10870	COG0174	glutamine synthetase
E5N77_RS10875	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5N77_RS11010	COG0745	RESPONSE REGULATOR receiver
E5N77_RS11025	COG2197	response regulator
E5N77_RS11075	COG0366	Alpha amylase catalytic
E5N77_RS11080	COG3833	ABC-type maltose transport systems, permease component
E5N77_RS11085	COG1175	transmembrane transport
E5N77_RS11090	COG1653	transport
E5N77_RS11095	COG1609	Transcriptional regulator
E5N77_RS11105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5N77_RS11115	COG2161	toxin-antitoxin pair type II binding
E5N77_RS11120	COG4115	mRNA cleavage
E5N77_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS11135	COG3321	synthase
E5N77_RS11135	COG0604	alcohol dehydrogenase
E5N77_RS11140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5N77_RS11140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5N77_RS11160	COG0174	glutamine synthetase
E5N77_RS11185	COG2814	Major facilitator Superfamily
E5N77_RS11195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5N77_RS11215	COG1994	Peptidase M50
E5N77_RS11275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS11280	COG1120	ATPase activity
E5N77_RS11310	COG2814	Major facilitator Superfamily
E5N77_RS11320	COG3540	Alkaline phosphatase
E5N77_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS11375	COG0789	Transcriptional regulator
E5N77_RS11385	COG3022	response to hydroperoxide
E5N77_RS11390	COG0800	Aldolase
E5N77_RS11405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5N77_RS11420	COG2030	dehydratase
E5N77_RS11425	COG1131	(ABC) transporter
E5N77_RS11435	COG4585	Histidine kinase
E5N77_RS11440	COG2197	response regulator
E5N77_RS11450	COG0477	Major facilitator Superfamily
E5N77_RS11460	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5N77_RS11460	COG2247	cell wall binding repeat
E5N77_RS11485	COG0297	glycogen (starch) synthase activity
E5N77_RS11490	COG1309	transcriptional regulator
E5N77_RS11510	COG3845	ABC transporter
E5N77_RS11545	COG0477	Major facilitator Superfamily
E5N77_RS11550	COG4122	O-methyltransferase activity
E5N77_RS11655	COG4585	Histidine kinase
E5N77_RS11660	COG0586	Pfam SNARE associated Golgi protein
E5N77_RS11670	COG1358	cellular component organization or biogenesis
E5N77_RS11720	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E5N77_RS11725	COG0477	Major facilitator Superfamily
E5N77_RS11740	COG0667	Aldo Keto reductase
E5N77_RS11745	COG0789	Transcriptional regulator
E5N77_RS11775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5N77_RS11780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5N77_RS11785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5N77_RS11825	COG1764	response to oxidative stress
E5N77_RS11830	COG2130	NADP-dependent
E5N77_RS11870	COG1129	ABC transporter
E5N77_RS11875	COG4214	carbohydrate transport
E5N77_RS11885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5N77_RS11890	COG3507	Belongs to the glycosyl hydrolase 43 family
E5N77_RS11895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5N77_RS11915	COG0395	ABC-type sugar transport system, permease component
E5N77_RS11920	COG1175	transmembrane transport
E5N77_RS11950	COG3386	PFAM SMP-30 Gluconolaconase
E5N77_RS11955	COG1414	Transcriptional regulator
E5N77_RS11970	COG2186	Transcriptional regulator
E5N77_RS11980	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS11985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5N77_RS11985	COG0825	malonyl-CoA metabolic process
E5N77_RS11990	COG1404	Belongs to the peptidase S8 family
E5N77_RS12015	COG1077	Cell shape determining protein MreB Mrl
E5N77_RS12050	COG1070	Carbohydrate kinase
E5N77_RS12075	COG0358	DNA primase activity
E5N77_RS12085	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E5N77_RS12095	COG2949	membrane
E5N77_RS12100	COG0243	molybdopterin cofactor binding
E5N77_RS12130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5N77_RS12135	COG2146	nitrite reductase [NAD(P)H] activity
E5N77_RS12135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5N77_RS12155	COG0574	Belongs to the PEP-utilizing enzyme family
E5N77_RS12155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5N77_RS12190	COG0477	Major facilitator Superfamily
E5N77_RS12200	COG0423	glycine-tRNA ligase activity
E5N77_RS12205	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5N77_RS12205	COG3443	Belongs to the bacterial solute-binding protein 9 family
E5N77_RS12210	COG1121	(ABC) transporter
E5N77_RS12215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5N77_RS12225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5N77_RS12230	COG1381	Involved in DNA repair and RecF pathway recombination
E5N77_RS12265	COG2197	response regulator
E5N77_RS12270	COG4585	Histidine kinase
E5N77_RS12275	COG2409	Drug exporters of the RND superfamily
E5N77_RS12295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5N77_RS12320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5N77_RS12330	COG2315	Protein conserved in bacteria
E5N77_RS12365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5N77_RS12370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5N77_RS12380	COG4948	Mandelate Racemase Muconate Lactonizing
E5N77_RS12385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5N77_RS12390	COG1414	Transcriptional regulator
E5N77_RS12400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5N77_RS12405	COG1234	tRNA 3'-trailer cleavage
E5N77_RS12410	COG0537	adenosine 5'-monophosphoramidase activity
E5N77_RS12415	COG0793	Belongs to the peptidase S41A family
E5N77_RS12415	COG4946	Tricorn protease homolog
E5N77_RS12435	COG0484	heat shock protein binding
E5N77_RS12440	COG1420	regulation of RNA biosynthetic process
E5N77_RS12470	COG0481	GTPase activity
E5N77_RS12475	COG0268	Binds directly to 16S ribosomal RNA
E5N77_RS12490	COG2353	YceI-like domain
E5N77_RS12500	COG1234	tRNA 3'-trailer cleavage
E5N77_RS12505	COG1555	photosystem II stabilization
E5N77_RS12510	COG1307	EDD domain protein, DegV family
E5N77_RS12520	COG0495	leucyl-tRNA aminoacylation
E5N77_RS12535	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5N77_RS12560	COG0588	phosphoglycerate mutase activity
E5N77_RS12565	COG0799	negative regulation of ribosome biogenesis
E5N77_RS12575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5N77_RS12590	COG0501	Belongs to the peptidase M48B family
E5N77_RS12605	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5N77_RS12615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5N77_RS12630	COG1216	Glycosyl transferase, family 2
E5N77_RS12635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5N77_RS12635	COG0463	Glycosyl transferase, family 2
E5N77_RS12640	COG0438	transferase activity, transferring glycosyl groups
E5N77_RS12645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5N77_RS12650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5N77_RS12655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5N77_RS12660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5N77_RS12665	COG0371	Dehydrogenase
E5N77_RS12670	COG1530	ribonuclease E activity
E5N77_RS12690	COG0772	Belongs to the SEDS family
E5N77_RS12695	COG0768	penicillin binding
E5N77_RS12710	COG1077	Cell shape determining protein MreB Mrl
E5N77_RS12715	COG0105	UTP biosynthetic process
E5N77_RS12725	COG0285	dihydrofolate synthase activity
E5N77_RS12730	COG0525	valine-tRNA ligase activity
E5N77_RS12740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5N77_RS12745	COG0740	serine-type endopeptidase activity
E5N77_RS12750	COG0740	serine-type endopeptidase activity
E5N77_RS12755	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5N77_RS12775	COG3594	Acyltransferase
E5N77_RS12790	COG4552	Acetyltransferase involved in intracellular survival and related
E5N77_RS12805	COG1113	amino acid transport
E5N77_RS12810	COG1268	BioY protein
E5N77_RS12815	COG1113	amino acid transport
E5N77_RS12820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5N77_RS12830	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5N77_RS12890	COG0697	spore germination
E5N77_RS12895	COG1846	Transcriptional regulator
E5N77_RS12920	COG0668	transmembrane transport
E5N77_RS12930	COG1486	melibiose metabolic process
E5N77_RS12945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5N77_RS12975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5N77_RS12995	COG1136	(ABC) transporter
E5N77_RS12995	COG0577	efflux transmembrane transporter activity
E5N77_RS13035	COG0629	single-stranded DNA binding
E5N77_RS13060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5N77_RS13075	COG2304	oxidoreductase activity
E5N77_RS13105	COG0297	glycogen (starch) synthase activity
E5N77_RS13110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5N77_RS13120	COG0728	peptidoglycan biosynthetic process
E5N77_RS13130	COG0297	glycogen (starch) synthase activity
E5N77_RS13150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5N77_RS13220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5N77_RS13245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5N77_RS13255	COG0640	Transcriptional regulator
E5N77_RS13260	COG1595	DNA-templated transcription, initiation
E5N77_RS13270	COG1609	Transcriptional regulator
E5N77_RS13275	COG1129	ABC transporter
E5N77_RS13285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5N77_RS13290	COG1869	D-ribose catabolic process
E5N77_RS13305	COG0673	inositol 2-dehydrogenase activity
E5N77_RS13310	COG1609	Transcriptional regulator
E5N77_RS13320	COG0488	(ABC) transporter
E5N77_RS13335	COG1472	Belongs to the glycosyl hydrolase 3 family
E5N77_RS13385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5N77_RS13390	COG2356	endonuclease I
E5N77_RS13395	COG0028	Belongs to the TPP enzyme family
E5N77_RS13425	COG1946	Acyl-CoA thioesterase
E5N77_RS13435	COG1309	transcriptional regulator
E5N77_RS13440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5N77_RS13455	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS13475	COG3486	L-lysine 6-monooxygenase (NADPH) activity
E5N77_RS13505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5N77_RS13510	COG0589	response to stress
E5N77_RS13520	COG4977	sequence-specific DNA binding
E5N77_RS13525	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5N77_RS13550	COG0395	ABC-type sugar transport system, permease component
E5N77_RS13565	COG0745	RESPONSE REGULATOR receiver
E5N77_RS13575	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5N77_RS13615	COG1846	Transcriptional regulator
E5N77_RS13655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5N77_RS13655	COG0596	Alpha beta hydrolase
E5N77_RS13675	COG0477	Major facilitator Superfamily
E5N77_RS13690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5N77_RS13735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5N77_RS13750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5N77_RS13755	COG0765	amino acid transport
E5N77_RS13760	COG0765	amino acid transport
E5N77_RS13765	COG1126	abc transporter atp-binding protein
E5N77_RS13780	COG3397	chitin binding
E5N77_RS13850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5N77_RS13855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5N77_RS13860	COG2188	Transcriptional regulator
E5N77_RS13880	COG0673	inositol 2-dehydrogenase activity
E5N77_RS13885	COG4702	Belongs to the UPF0303 family
E5N77_RS13940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5N77_RS13960	COG2814	Major facilitator Superfamily
E5N77_RS13965	COG2733	membrane
E5N77_RS13980	COG4555	ABC transporter
E5N77_RS13995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5N77_RS14025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5N77_RS14035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5N77_RS14040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5N77_RS14045	COG1263	PTS System
E5N77_RS14050	COG1263	PTS System
E5N77_RS14055	COG1234	tRNA 3'-trailer cleavage
E5N77_RS14085	COG1113	amino acid transport
E5N77_RS14100	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5N77_RS14110	COG1335	isochorismatase
E5N77_RS14135	COG1714	RDD family
E5N77_RS14150	COG0277	FAD linked oxidase domain protein
E5N77_RS14160	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E5N77_RS14170	COG1174	glycine betaine transport
E5N77_RS14180	COG1174	glycine betaine transport
E5N77_RS14190	COG3480	Lon protease (S16) C-terminal proteolytic domain
E5N77_RS14220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5N77_RS14235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
E5N77_RS14240	COG0395	ABC-type sugar transport system, permease component
E5N77_RS14245	COG1175	transmembrane transport
E5N77_RS14260	COG1678	Uncharacterized ACR, COG1678
E5N77_RS14265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5N77_RS14270	COG0776	regulation of translation
E5N77_RS14280	COG3973	AAA domain
E5N77_RS14305	COG2223	nitrite transmembrane transporter activity
E5N77_RS14340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5N77_RS14345	COG0793	Belongs to the peptidase S41A family
E5N77_RS14355	COG2884	Cell division ATP-binding protein ftsE
E5N77_RS14370	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E5N77_RS14375	COG0515	serine threonine protein kinase
E5N77_RS14380	COG0515	serine threonine protein kinase
E5N77_RS14395	COG1175	transmembrane transport
E5N77_RS14400	COG0395	ABC-type sugar transport system, permease component
E5N77_RS14405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5N77_RS14410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5N77_RS14430	COG1764	response to oxidative stress
E5N77_RS14435	COG1846	Transcriptional regulator
E5N77_RS14460	COG1134	teichoic acid transport
E5N77_RS14465	COG2902	Dehydrogenase
E5N77_RS14485	COG0653	protein targeting
E5N77_RS14495	COG3214	Protein conserved in bacteria
E5N77_RS14500	COG2197	response regulator
E5N77_RS14505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E5N77_RS14520	COG0823	Involved in the tonB-independent uptake of proteins
E5N77_RS14525	COG5002	protein histidine kinase activity
E5N77_RS14525	COG5000	phosphorelay sensor kinase activity
E5N77_RS14530	COG0745	RESPONSE REGULATOR receiver
E5N77_RS14535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E5N77_RS14555	COG0714	Associated with various cellular activities
E5N77_RS14600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5N77_RS14610	COG1482	cell wall glycoprotein biosynthetic process
E5N77_RS14625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5N77_RS14630	COG1620	l-lactate permease
E5N77_RS14670	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5N77_RS14675	COG0778	Nitroreductase
E5N77_RS14675	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
E5N77_RS14705	COG1316	TRANSCRIPTIONal
E5N77_RS14710	COG1316	TRANSCRIPTIONal
E5N77_RS14715	COG1316	TRANSCRIPTIONal
E5N77_RS14720	COG1316	TRANSCRIPTIONal
E5N77_RS14735	COG1316	TRANSCRIPTIONal
E5N77_RS14740	COG1316	TRANSCRIPTIONal
E5N77_RS14755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5N77_RS14790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5N77_RS14805	COG2205	protein histidine kinase activity
E5N77_RS14810	COG0745	RESPONSE REGULATOR receiver
E5N77_RS14815	COG3104	oligopeptide transport
E5N77_RS14825	COG1366	Belongs to the anti-sigma-factor antagonist family
E5N77_RS14830	COG1191	sigma factor activity
E5N77_RS14840	COG1228	amidohydrolase
E5N77_RS14850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5N77_RS14855	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5N77_RS14885	COG2755	lipolytic protein G-D-S-L family
E5N77_RS14890	COG0183	Belongs to the thiolase family
E5N77_RS14930	COG1136	(ABC) transporter
E5N77_RS14935	COG0577	efflux transmembrane transporter activity
E5N77_RS14940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5N77_RS14945	COG1252	NADH dehydrogenase
E5N77_RS14965	COG0148	phosphopyruvate hydratase activity
E5N77_RS15040	COG0577	efflux transmembrane transporter activity
E5N77_RS15045	COG1136	(ABC) transporter
E5N77_RS15050	COG0477	Major facilitator Superfamily
E5N77_RS15060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5N77_RS15095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5N77_RS15100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5N77_RS15105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5N77_RS15110	COG0193	aminoacyl-tRNA hydrolase activity
E5N77_RS15120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5N77_RS15130	COG1309	transcriptional regulator
E5N77_RS15140	COG4106	trans-aconitate 2-methyltransferase activity
E5N77_RS15150	COG2197	response regulator
E5N77_RS15160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5N77_RS15205	COG0488	(ABC) transporter
E5N77_RS15210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5N77_RS15215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5N77_RS15225	COG0084	hydrolase, TatD family'
E5N77_RS15260	COG0310	cobalt ion transport
E5N77_RS15270	COG1122	ATPase activity
E5N77_RS15275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E5N77_RS15285	COG0442	prolyl-tRNA aminoacylation
E5N77_RS15290	COG2409	Drug exporters of the RND superfamily
E5N77_RS15300	COG0793	Belongs to the peptidase S41A family
E5N77_RS15300	COG4946	Tricorn protease homolog
E5N77_RS15315	COG2267	carboxylic ester hydrolase activity
E5N77_RS15320	COG2072	flavoprotein involved in K transport
E5N77_RS15350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5N77_RS15355	COG0315	cyclic pyranopterin monophosphate synthase activity
E5N77_RS15355	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5N77_RS15360	COG0315	cyclic pyranopterin monophosphate synthase activity
E5N77_RS15370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5N77_RS15375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5N77_RS15400	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E5N77_RS15410	COG1970	mechanosensitive ion channel activity
E5N77_RS15425	COG3191	aminopeptidase activity
E5N77_RS15450	COG1349	DNA-binding transcription factor activity
E5N77_RS15455	COG0477	Major facilitator Superfamily
E5N77_RS15470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5N77_RS15475	COG1247	-acetyltransferase
E5N77_RS15480	COG3384	dioxygenase
E5N77_RS15485	COG1846	Transcriptional regulator
E5N77_RS15505	COG1414	Transcriptional regulator
E5N77_RS15515	COG0582	viral genome integration into host DNA
E5N77_RS15640	COG2814	Major facilitator Superfamily
E5N77_RS15655	COG1309	transcriptional regulator
E5N77_RS15660	COG4257	antibiotic catabolic process
E5N77_RS15670	COG2208	phosphoserine phosphatase activity
E5N77_RS15685	COG0386	Belongs to the glutathione peroxidase family
E5N77_RS15710	COG1686	Belongs to the peptidase S11 family
E5N77_RS15735	COG0583	DNA-binding transcription factor activity
E5N77_RS15765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E5N77_RS15785	COG3903	Transcriptional regulator
E5N77_RS15785	COG3629	intracellular signal transduction
E5N77_RS15795	COG0515	serine threonine protein kinase
E5N77_RS15795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5N77_RS15805	COG1309	transcriptional regulator
E5N77_RS15825	COG0259	pyridoxamine-phosphate oxidase activity
E5N77_RS15835	COG2072	flavoprotein involved in K transport
E5N77_RS15840	COG2271	Major facilitator Superfamily
E5N77_RS15865	COG1366	Belongs to the anti-sigma-factor antagonist family
E5N77_RS15930	COG0596	Alpha beta hydrolase
E5N77_RS15930	COG2945	thiolester hydrolase activity
E5N77_RS15940	COG4821	SIS domain
E5N77_RS15960	COG0259	pyridoxamine-phosphate oxidase activity
E5N77_RS15975	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS15990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5N77_RS16005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5N77_RS16005	COG0515	serine threonine protein kinase
E5N77_RS16030	COG0277	FAD linked oxidase domain protein
E5N77_RS16030	COG0247	lactate metabolic process
E5N77_RS16035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5N77_RS16075	COG0667	Aldo Keto reductase
E5N77_RS16100	COG2252	PERMEase
E5N77_RS16115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5N77_RS16130	COG2814	Major facilitator Superfamily
E5N77_RS16140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5N77_RS16145	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E5N77_RS16150	COG1278	Cold shock
E5N77_RS16185	COG1061	Type III restriction enzyme res subunit
E5N77_RS16195	COG3973	AAA domain
E5N77_RS16235	COG1737	Transcriptional regulator
E5N77_RS16240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E5N77_RS16270	COG0459	protein refolding
E5N77_RS16275	COG1278	Cold shock
E5N77_RS16290	COG0463	Glycosyl transferase, family 2
E5N77_RS16325	COG1105	Belongs to the carbohydrate kinase PfkB family
E5N77_RS16335	COG5001	Diguanylate cyclase
E5N77_RS16335	COG3300	MHYT domain
E5N77_RS16360	COG2197	response regulator
E5N77_RS16365	COG4585	Histidine kinase
E5N77_RS16405	COG0723	plastoquinol--plastocyanin reductase activity
E5N77_RS16405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5N77_RS16435	COG0464	growth
E5N77_RS16525	COG3842	ATPase activity
E5N77_RS16550	COG0215	cysteine-tRNA ligase activity
E5N77_RS16555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5N77_RS16560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5N77_RS16570	COG1329	Transcriptional regulator
E5N77_RS16590	COG5002	protein histidine kinase activity
E5N77_RS16630	COG2318	DinB family
E5N77_RS16640	COG2172	sigma factor antagonist activity
E5N77_RS16650	COG0222	ribosome binding
E5N77_RS16655	COG0588	phosphoglycerate mutase activity
E5N77_RS16680	COG0438	transferase activity, transferring glycosyl groups
E5N77_RS16715	COG2815	serine threonine protein kinase
E5N77_RS16715	COG0515	serine threonine protein kinase
E5N77_RS16720	COG1733	regulation of RNA biosynthetic process
E5N77_RS16725	COG2084	Dehydrogenase
E5N77_RS16740	COG0546	phosphoglycolate phosphatase activity
E5N77_RS16745	COG0546	phosphoglycolate phosphatase activity
E5N77_RS16750	COG2186	Transcriptional regulator
E5N77_RS16765	COG4552	Acetyltransferase involved in intracellular survival and related
E5N77_RS16780	COG1490	D-aminoacyl-tRNA deacylase activity
E5N77_RS16790	COG0735	belongs to the Fur family
E5N77_RS16795	COG3485	protocatechuate 3,4-dioxygenase
E5N77_RS16815	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS16835	COG2897	thiosulfate sulfurtransferase activity
E5N77_RS16860	COG0745	RESPONSE REGULATOR receiver
E5N77_RS16865	COG1609	Transcriptional regulator
E5N77_RS16870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5N77_RS16875	COG0745	RESPONSE REGULATOR receiver
E5N77_RS16905	COG0737	Belongs to the 5'-nucleotidase family
E5N77_RS16910	COG0456	acetyltransferase
E5N77_RS16925	COG1131	(ABC) transporter
E5N77_RS16940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5N77_RS16950	COG0406	alpha-ribazole phosphatase activity
E5N77_RS16950	COG0494	nUDIX hydrolase
E5N77_RS16970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5N77_RS16975	COG0306	phosphate transporter
E5N77_RS16985	COG1937	Protein conserved in bacteria
E5N77_RS17005	COG0671	phosphoesterase, PA-phosphatase related
E5N77_RS17010	COG0741	lytic transglycosylase activity
E5N77_RS17010	COG1196	nuclear chromosome segregation
E5N77_RS17010	COG0739	heme binding
E5N77_RS17055	COG2197	response regulator
E5N77_RS17095	COG1252	NADH dehydrogenase
E5N77_RS17120	COG0579	oxidoreductase
E5N77_RS17125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5N77_RS17155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5N77_RS17155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5N77_RS17170	COG0513	Belongs to the DEAD box helicase family
E5N77_RS17205	COG1643	Atp-dependent helicase
E5N77_RS17245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5N77_RS17285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5N77_RS17290	COG0047	phosphoribosylformylglycinamidine synthase activity
E5N77_RS17295	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5N77_RS17325	COG3851	Histidine kinase
E5N77_RS17330	COG2197	response regulator
E5N77_RS17340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5N77_RS17355	COG0151	Belongs to the GarS family
E5N77_RS17375	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS17380	COG0583	DNA-binding transcription factor activity
E5N77_RS17390	COG1276	copper resistance
E5N77_RS17390	COG2372	response to copper ion
E5N77_RS17400	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS17455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5N77_RS17490	COG1191	sigma factor activity
E5N77_RS17495	COG1191	sigma factor activity
E5N77_RS17515	COG2353	YceI-like domain
E5N77_RS17540	COG3467	pyridoxamine 5'-phosphate
E5N77_RS17550	COG0477	Major facilitator Superfamily
E5N77_RS17555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5N77_RS17565	COG2205	protein histidine kinase activity
E5N77_RS17570	COG0745	RESPONSE REGULATOR receiver
E5N77_RS17585	COG1733	regulation of RNA biosynthetic process
E5N77_RS17590	COG0768	penicillin binding
E5N77_RS17615	COG0784	Response regulator, receiver
E5N77_RS17620	COG1309	transcriptional regulator
E5N77_RS17625	COG2814	Major facilitator Superfamily
E5N77_RS17630	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS17635	COG1595	DNA-templated transcription, initiation
E5N77_RS17660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5N77_RS17695	COG0006	proline dipeptidase activity
E5N77_RS17720	COG1999	signal sequence binding
E5N77_RS17735	COG2837	iron assimilation
E5N77_RS17740	COG0077	Prephenate dehydratase
E5N77_RS17745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5N77_RS17750	COG0561	phosphatase activity
E5N77_RS17790	COG0561	phosphatase activity
E5N77_RS17795	COG0739	heme binding
E5N77_RS17805	COG4988	ABC transporter
E5N77_RS17810	COG1294	oxidase, subunit
E5N77_RS17815	COG1271	oxidase subunit
E5N77_RS17825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5N77_RS17830	COG1609	Transcriptional regulator
E5N77_RS17845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5N77_RS17870	COG0662	Cupin 2, conserved barrel domain protein
E5N77_RS17875	COG1950	PFAM Membrane protein of
E5N77_RS17880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5N77_RS17885	COG0626	cystathionine gamma-synthase activity
E5N77_RS17910	COG2814	Major facilitator Superfamily
E5N77_RS17930	COG0305	Participates in initiation and elongation during chromosome replication
E5N77_RS17940	COG0359	binds to the 23S rRNA
E5N77_RS17945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5N77_RS17950	COG0629	single-stranded DNA binding
E5N77_RS17955	COG0360	Binds together with S18 to 16S ribosomal RNA
E5N77_RS17980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5N77_RS18010	COG0617	tRNA 3'-terminal CCA addition
E5N77_RS18030	COG1595	DNA-templated transcription, initiation
E5N77_RS18040	COG0492	ferredoxin-NADP+ reductase activity
E5N77_RS18045	COG3118	belongs to the thioredoxin family
E5N77_RS18060	COG1192	Involved in chromosome partitioning
E5N77_RS18065	COG0357	Ribosomal RNA small subunit methyltransferase G
E5N77_RS18075	COG0706	membrane insertase activity
E5N77_RS18080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5N77_RS18085	COG0594	ribonuclease P activity
E5N77_RS18090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5N77_RS18095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5N77_RS18105	COG0592	DNA-directed DNA polymerase activity
E5N77_RS18110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E5N77_RS18115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5N77_RS18120	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E5N77_RS18125	COG0187	DNA topoisomerase II activity
E5N77_RS18130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5N77_RS18145	COG2319	Wd-40 repeat
E5N77_RS18145	COG4249	Peptidase C14 caspase catalytic subunit p20
E5N77_RS18205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5N77_RS18210	COG0431	NADPH-dependent FMN reductase
E5N77_RS18215	COG1045	serine acetyltransferase
E5N77_RS18230	COG0151	Belongs to the GarS family
E5N77_RS18240	COG1942	4-Oxalocrotonate Tautomerase
E5N77_RS18260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5N77_RS18275	COG0705	Rhomboid family
E5N77_RS18300	COG3764	Sortase (surface protein transpeptidase)
E5N77_RS18305	COG3764	Sortase (surface protein transpeptidase)
E5N77_RS18310	COG0515	serine threonine protein kinase
E5N77_RS18320	COG0768	penicillin binding
E5N77_RS18335	COG1716	ATPase activity
E5N77_RS18340	COG1716	ATPase activity
E5N77_RS18390	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5N77_RS18395	COG1309	transcriptional regulator
E5N77_RS18400	COG1522	sequence-specific DNA binding
E5N77_RS18445	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS18445	COG0604	alcohol dehydrogenase
E5N77_RS18445	COG3321	synthase
E5N77_RS18460	COG0515	serine threonine protein kinase
E5N77_RS18465	COG0515	serine threonine protein kinase
E5N77_RS18485	COG0022	dehydrogenase e1 component
E5N77_RS18490	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5N77_RS18510	COG2186	Transcriptional regulator
E5N77_RS18545	COG1362	aminopeptidase activity
E5N77_RS18550	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS18560	COG1741	Belongs to the pirin family
E5N77_RS18575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5N77_RS18595	COG0326	Molecular chaperone. Has ATPase activity
E5N77_RS18605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5N77_RS18655	COG1653	transport
E5N77_RS18680	COG0366	Alpha amylase catalytic
E5N77_RS18705	COG0583	DNA-binding transcription factor activity
E5N77_RS18765	COG0513	Belongs to the DEAD box helicase family
E5N77_RS18770	COG1278	Cold shock
E5N77_RS18810	COG0475	glutathione-regulated potassium exporter activity
E5N77_RS18810	COG0569	domain protein
E5N77_RS18830	COG0640	Transcriptional regulator
E5N77_RS18880	COG0717	Belongs to the dCTP deaminase family
E5N77_RS18885	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E5N77_RS18895	COG0247	lactate metabolic process
E5N77_RS18895	COG2181	nitrate reductase activity
E5N77_RS18900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5N77_RS18905	COG0443	Heat shock 70 kDa protein
E5N77_RS18910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5N77_RS18915	COG0484	heat shock protein binding
E5N77_RS18920	COG0789	Transcriptional regulator
E5N77_RS18945	COG1132	(ABC) transporter
E5N77_RS18975	COG2226	methyltransferase
E5N77_RS18980	COG0612	Peptidase, M16
E5N77_RS18995	COG4213	ABC transporter substrate-binding protein
E5N77_RS19020	COG0542	response to heat
E5N77_RS19050	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5N77_RS19055	COG4585	Histidine kinase
E5N77_RS19060	COG2197	response regulator
E5N77_RS19075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5N77_RS19080	COG0191	fructose-bisphosphate aldolase activity
E5N77_RS19085	COG0477	Major facilitator Superfamily
E5N77_RS19100	COG3844	kynureninase activity
E5N77_RS19125	COG4585	Histidine kinase
E5N77_RS19130	COG2197	response regulator
E5N77_RS19135	COG4585	Histidine kinase
E5N77_RS19140	COG2197	response regulator
E5N77_RS19150	COG3559	Exporter of polyketide antibiotics
E5N77_RS19155	COG1131	(ABC) transporter
E5N77_RS19170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5N77_RS19185	COG1595	DNA-templated transcription, initiation
E5N77_RS19200	COG1802	Transcriptional regulator
E5N77_RS19210	COG0693	protein deglycase activity
E5N77_RS19225	COG2319	Wd-40 repeat
E5N77_RS19225	COG4249	Peptidase C14 caspase catalytic subunit p20
E5N77_RS19240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5N77_RS19245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5N77_RS19265	COG1595	DNA-templated transcription, initiation
E5N77_RS19290	COG1585	Membrane protein implicated in regulation of membrane protease activity
E5N77_RS19310	COG3655	Transcriptional regulator
E5N77_RS19330	COG3263	regulation of cellular component size
E5N77_RS19345	COG0515	serine threonine protein kinase
E5N77_RS19355	COG1132	(ABC) transporter
E5N77_RS19360	COG1132	(ABC) transporter
E5N77_RS19365	COG2197	response regulator
E5N77_RS19370	COG1115	amino acid carrier protein
E5N77_RS19390	COG2255	four-way junction helicase activity
E5N77_RS19480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5N77_RS19485	COG2192	nodulation
E5N77_RS19500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5N77_RS19510	COG0297	glycogen (starch) synthase activity
E5N77_RS19600	COG1408	metallophosphoesterase
E5N77_RS19610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5N77_RS19625	COG0003	Pfam Anion-transporting ATPase
E5N77_RS19640	COG0251	oxidation-reduction process
E5N77_RS19645	COG0596	Alpha beta hydrolase
E5N77_RS19655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5N77_RS19685	COG2267	carboxylic ester hydrolase activity
E5N77_RS19695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5N77_RS19700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5N77_RS19705	COG0659	secondary active sulfate transmembrane transporter activity
E5N77_RS19770	COG1366	Belongs to the anti-sigma-factor antagonist family
E5N77_RS19775	COG2172	sigma factor antagonist activity
E5N77_RS19780	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E5N77_RS19790	COG2264	protein methyltransferase activity
E5N77_RS19800	COG1754	DNA topoisomerase type I activity
E5N77_RS19800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5N77_RS19805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5N77_RS19810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5N77_RS19830	COG3903	Transcriptional regulator
E5N77_RS19830	COG3629	intracellular signal transduction
E5N77_RS19855	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5N77_RS19860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5N77_RS19865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5N77_RS19870	COG0254	rRNA binding
E5N77_RS19880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5N77_RS19905	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS19925	COG0076	glutamate decarboxylase activity
E5N77_RS19930	COG0789	Transcriptional regulator
E5N77_RS19935	COG0393	Putative heavy-metal-binding
E5N77_RS19940	COG0586	Pfam SNARE associated Golgi protein
E5N77_RS19950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5N77_RS19955	COG2027	D-alanyl-D-alanine carboxypeptidase
E5N77_RS19965	COG0037	tRNA processing
E5N77_RS19980	COG0302	gtp cyclohydrolase
E5N77_RS19995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5N77_RS20015	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E5N77_RS20015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E5N77_RS20040	COG0649	NAD binding
E5N77_RS20060	COG1660	Displays ATPase and GTPase activities
E5N77_RS20090	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5N77_RS20095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5N77_RS20105	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E5N77_RS20130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5N77_RS20165	COG0739	heme binding
E5N77_RS20180	COG2205	protein histidine kinase activity
E5N77_RS20185	COG0745	RESPONSE REGULATOR receiver
E5N77_RS20195	COG1595	DNA-templated transcription, initiation
E5N77_RS20200	COG1194	a g-specific adenine glycosylase
E5N77_RS20205	COG4585	Histidine kinase
E5N77_RS20215	COG0671	phosphoesterase, PA-phosphatase related
E5N77_RS20225	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E5N77_RS20255	COG0248	Ppx GppA phosphatase
E5N77_RS20265	COG1082	Xylose isomerase domain protein TIM barrel
E5N77_RS20270	COG1309	transcriptional regulator
E5N77_RS20275	COG0129	dihydroxy-acid dehydratase activity
E5N77_RS20280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5N77_RS20280	COG0515	serine threonine protein kinase
E5N77_RS20315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5N77_RS20320	COG0180	Tryptophanyl-tRNA synthetase
E5N77_RS20345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5N77_RS20355	COG2223	nitrite transmembrane transporter activity
E5N77_RS20360	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5N77_RS20410	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E5N77_RS20415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5N77_RS20420	COG0181	hydroxymethylbilane synthase activity
E5N77_RS20425	COG1648	precorrin-2 dehydrogenase activity
E5N77_RS20425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5N77_RS20440	COG0113	porphobilinogen synthase activity
E5N77_RS20460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5N77_RS20470	COG0018	arginyl-trna synthetase
E5N77_RS20475	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E5N77_RS20495	COG1690	Belongs to the RtcB family
E5N77_RS20505	COG1742	UPF0060 membrane protein
E5N77_RS20510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5N77_RS20515	COG0431	NADPH-dependent FMN reductase
E5N77_RS20520	COG0745	RESPONSE REGULATOR receiver
E5N77_RS20580	COG1695	Transcriptional regulator
E5N77_RS20585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5N77_RS20590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5N77_RS20605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5N77_RS20610	COG0406	alpha-ribazole phosphatase activity
E5N77_RS20620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5N77_RS20625	COG0785	Cytochrome C biogenesis protein
E5N77_RS20630	COG1333	cytochrome c biogenesis protein
E5N77_RS20635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5N77_RS20645	COG0789	Transcriptional regulator
E5N77_RS20680	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E5N77_RS20685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5N77_RS20690	COG0163	prenyltransferase activity
E5N77_RS20700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E5N77_RS20705	COG1573	uracil-dna glycosylase
E5N77_RS20720	COG1301	dicarboxylic acid transport
E5N77_RS20730	COG1309	transcriptional regulator
E5N77_RS20735	COG1309	transcriptional regulator
E5N77_RS20750	COG0183	Belongs to the thiolase family
E5N77_RS20765	COG1278	Cold shock
E5N77_RS20770	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E5N77_RS20785	COG1674	ftsk spoiiie
E5N77_RS20880	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E5N77_RS20990	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E5N77_RS21025	COG2226	methyltransferase
E5N77_RS21040	COG0242	peptide deformylase activity
E5N77_RS21045	COG3103	Sh3 type 3 domain protein
E5N77_RS21045	COG0791	NLP P60 protein
E5N77_RS21045	COG1388	LysM domain
E5N77_RS21055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5N77_RS21060	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5N77_RS21065	COG0649	NAD binding
E5N77_RS21075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5N77_RS21080	COG1034	ATP synthesis coupled electron transport
E5N77_RS21085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5N77_RS21090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5N77_RS21100	COG0713	ATP synthesis coupled electron transport
E5N77_RS21105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5N77_RS21115	COG1007	ATP synthesis coupled electron transport
E5N77_RS21125	COG0514	ATP-dependent DNA helicase (RecQ)
E5N77_RS21140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5N77_RS21185	COG0561	phosphatase activity
E5N77_RS21195	COG0142	geranyltranstransferase activity
E5N77_RS21245	COG0702	epimerase
E5N77_RS21250	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5N77_RS21255	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5N77_RS21255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5N77_RS21275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5N77_RS21280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5N77_RS21285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5N77_RS21290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5N77_RS21295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5N77_RS21305	COG0713	ATP synthesis coupled electron transport
E5N77_RS21310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5N77_RS21320	COG1007	ATP synthesis coupled electron transport
E5N77_RS21325	COG0501	Belongs to the peptidase M48B family
E5N77_RS21330	COG3304	Inner membrane component domain
E5N77_RS21335	COG2261	transglycosylase associated protein
E5N77_RS21340	COG1666	GTP binding
E5N77_RS21355	COG0702	epimerase
E5N77_RS21360	COG0402	S-adenosylhomocysteine deaminase activity
E5N77_RS21375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5N77_RS21380	COG2030	dehydratase
E5N77_RS21395	COG0477	Major facilitator Superfamily
E5N77_RS21405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5N77_RS21410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5N77_RS21420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5N77_RS21425	COG0436	Aminotransferase
E5N77_RS21440	COG0250	Participates in transcription elongation, termination and antitermination
E5N77_RS21445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5N77_RS21450	COG0081	regulation of translation
E5N77_RS21465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5N77_RS21470	COG0222	ribosome binding
E5N77_RS21480	COG0085	RNA polymerase activity
E5N77_RS21485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5N77_RS21495	COG0463	Glycosyl transferase, family 2
E5N77_RS21500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5N77_RS21505	COG0049	tRNA binding
E5N77_RS21510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5N77_RS21515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5N77_RS21520	COG0577	efflux transmembrane transporter activity
E5N77_RS21525	COG1136	(ABC) transporter
E5N77_RS21530	COG4585	Histidine kinase
E5N77_RS21535	COG2197	response regulator
E5N77_RS21580	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS21590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5N77_RS21595	COG1278	Cold shock
E5N77_RS21600	COG0513	Belongs to the DEAD box helicase family
E5N77_RS21635	COG0051	transcription antitermination factor activity, RNA binding
E5N77_RS21640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5N77_RS21645	COG0088	Forms part of the polypeptide exit tunnel
E5N77_RS21650	COG0089	rRNA binding
E5N77_RS21655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5N77_RS21660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5N77_RS21665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5N77_RS21670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5N77_RS21675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5N77_RS21680	COG0255	Belongs to the universal ribosomal protein uL29 family
E5N77_RS21685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5N77_RS21690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5N77_RS21695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5N77_RS21700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5N77_RS21705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5N77_RS21715	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5N77_RS21720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5N77_RS21725	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5N77_RS21730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5N77_RS21735	COG1841	ribosomal large subunit assembly
E5N77_RS21740	COG0200	Binds to the 23S rRNA
E5N77_RS21745	COG0201	protein transport
E5N77_RS21750	COG0563	adenylate kinase activity
E5N77_RS21770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5N77_RS21775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5N77_RS21780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5N77_RS21785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5N77_RS21790	COG0202	RNA polymerase activity
E5N77_RS21795	COG0203	ribosomal protein L17
E5N77_RS21800	COG0101	tRNA pseudouridine synthase activity
E5N77_RS21815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5N77_RS21820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5N77_RS21825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5N77_RS21835	COG1072	(Pantothenic acid kinase))
E5N77_RS21845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5N77_RS21855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5N77_RS21855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5N77_RS21865	COG0736	holo-[acyl-carrier-protein] synthase activity
E5N77_RS21870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5N77_RS21880	COG0802	atpase or kinase
E5N77_RS21890	COG1214	PFAM Peptidase M22, glycoprotease
E5N77_RS21890	COG0456	acetyltransferase
E5N77_RS21900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5N77_RS21920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5N77_RS21920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5N77_RS21930	COG1609	Transcriptional regulator
E5N77_RS21935	COG1316	TRANSCRIPTIONal
E5N77_RS21945	COG0726	polysaccharide deacetylase
E5N77_RS21950	COG0726	polysaccharide deacetylase
E5N77_RS21955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5N77_RS21960	COG0459	protein refolding
E5N77_RS21965	COG1278	Cold shock
E5N77_RS21970	COG4221	oxidoreductase activity
E5N77_RS21980	COG0583	DNA-binding transcription factor activity
E5N77_RS21995	COG1595	DNA-templated transcription, initiation
E5N77_RS22005	COG0516	GMP reductase activity
E5N77_RS22015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5N77_RS22025	COG2815	serine threonine protein kinase
E5N77_RS22025	COG0515	serine threonine protein kinase
E5N77_RS22030	COG0515	serine threonine protein kinase
E5N77_RS22045	COG0515	serine threonine protein kinase
E5N77_RS22050	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS22070	COG0519	Catalyzes the synthesis of GMP from XMP
E5N77_RS22070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5N77_RS22105	COG2197	response regulator
E5N77_RS22110	COG0791	NLP P60 protein
E5N77_RS22135	COG0739	heme binding
E5N77_RS22145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5N77_RS22145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5N77_RS22160	COG0714	Associated with various cellular activities
E5N77_RS22165	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E5N77_RS22170	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E5N77_RS22185	COG0045	succinate-CoA ligase (ADP-forming) activity
E5N77_RS22215	COG0138	bifunctional purine biosynthesis protein purh
E5N77_RS22240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5N77_RS22255	COG0039	L-malate dehydrogenase activity
E5N77_RS22260	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS22270	COG0517	IMP dehydrogenase activity
E5N77_RS22270	COG4175	Glycine betaine
E5N77_RS22290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5N77_RS22295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5N77_RS22305	COG0754	glutathionylspermidine amidase activity
E5N77_RS22310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5N77_RS22315	COG0180	Tryptophanyl-tRNA synthetase
E5N77_RS22335	COG0671	phosphoesterase, PA-phosphatase related
E5N77_RS22350	COG1295	ribonuclease BN
E5N77_RS22355	COG1686	Belongs to the peptidase S11 family
E5N77_RS22365	COG1408	metallophosphoesterase
E5N77_RS22370	COG1309	transcriptional regulator
E5N77_RS22410	COG1053	succinate dehydrogenase
E5N77_RS22420	COG2009	succinate dehydrogenase
E5N77_RS22460	COG1595	DNA-templated transcription, initiation
E5N77_RS22475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5N77_RS22475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5N77_RS22505	COG1216	Glycosyl transferase, family 2
E5N77_RS22515	COG1216	Glycosyl transferase, family 2
E5N77_RS22530	COG2089	acid synthase
E5N77_RS22540	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E5N77_RS22540	COG1473	amidohydrolase
E5N77_RS22545	COG1744	ABC transporter substrate-binding protein PnrA-like
E5N77_RS22550	COG1744	ABC transporter substrate-binding protein PnrA-like
E5N77_RS22555	COG3845	ABC transporter
E5N77_RS22560	COG4603	Belongs to the binding-protein-dependent transport system permease family
E5N77_RS22565	COG1079	Belongs to the binding-protein-dependent transport system permease family
E5N77_RS22600	COG2814	Major facilitator Superfamily
E5N77_RS22605	COG0583	DNA-binding transcription factor activity
E5N77_RS22615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5N77_RS22640	COG2205	protein histidine kinase activity
E5N77_RS22645	COG0745	RESPONSE REGULATOR receiver
E5N77_RS22650	COG1595	DNA-templated transcription, initiation
E5N77_RS22665	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS22670	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS22690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5N77_RS22720	COG4770	biotin carboxylase activity
E5N77_RS22730	COG0424	maF-like protein
E5N77_RS22745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5N77_RS22755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E5N77_RS22765	COG1024	Enoyl-CoA hydratase
E5N77_RS22775	COG2986	histidine ammonia-lyase
E5N77_RS22795	COG1064	alcohol dehydrogenase
E5N77_RS22800	COG1090	epimerase
E5N77_RS22805	COG0667	Aldo Keto reductase
E5N77_RS22820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5N77_RS22845	COG2255	four-way junction helicase activity
E5N77_RS22850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5N77_RS22865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5N77_RS22875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5N77_RS22905	COG0590	tRNA wobble adenosine to inosine editing
E5N77_RS22910	COG1331	Highly conserved protein containing a thioredoxin domain
E5N77_RS22945	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E5N77_RS22980	COG0436	Aminotransferase
E5N77_RS22985	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E5N77_RS23000	COG1414	Transcriptional regulator
E5N77_RS23005	COG0251	oxidation-reduction process
E5N77_RS23010	COG2610	gluconate transmembrane transporter activity
E5N77_RS23065	COG2894	cell division
E5N77_RS23095	COG3920	Histidine kinase
E5N77_RS23100	COG2197	response regulator
E5N77_RS23175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E5N77_RS23190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5N77_RS23195	COG0450	alkyl hydroperoxide reductase
E5N77_RS23210	COG1136	(ABC) transporter
E5N77_RS23220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5N77_RS23235	COG0114	fumarate hydratase activity
E5N77_RS23240	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E5N77_RS23240	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E5N77_RS23265	COG0778	Nitroreductase
E5N77_RS23275	COG1722	exodeoxyribonuclease VII activity
E5N77_RS23280	COG1570	exodeoxyribonuclease VII activity
E5N77_RS23290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5N77_RS23305	COG0012	GTP binding
E5N77_RS23370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5N77_RS23375	COG1053	succinate dehydrogenase
E5N77_RS23395	COG1217	gtp-binding protein TYPA
E5N77_RS23400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5N77_RS23405	COG4166	transmembrane transport
E5N77_RS23410	COG0601	transmembrane transport
E5N77_RS23415	COG0444	Belongs to the ABC transporter superfamily
E5N77_RS23420	COG4608	Belongs to the ABC transporter superfamily
E5N77_RS23425	COG4608	Belongs to the ABC transporter superfamily
E5N77_RS23430	COG0444	Belongs to the ABC transporter superfamily
E5N77_RS23435	COG0601	transmembrane transport
E5N77_RS23440	COG0747	negative chemotaxis
E5N77_RS23445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5N77_RS23455	COG0601	transmembrane transport
E5N77_RS23460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5N77_RS23465	COG0444	Belongs to the ABC transporter superfamily
E5N77_RS23470	COG4608	Belongs to the ABC transporter superfamily
E5N77_RS23485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5N77_RS23505	COG0456	acetyltransferase
E5N77_RS23505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5N77_RS23530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5N77_RS23540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5N77_RS23550	COG0519	Catalyzes the synthesis of GMP from XMP
E5N77_RS23555	COG1024	Enoyl-CoA hydratase
E5N77_RS23570	COG1595	DNA-templated transcription, initiation
E5N77_RS23580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5N77_RS23585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5N77_RS23610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5N77_RS23620	COG0598	Magnesium transport protein CorA
E5N77_RS23630	COG2814	Major facilitator Superfamily
E5N77_RS23645	COG2095	MarC family integral membrane protein
E5N77_RS23655	COG1432	Conserved Protein
E5N77_RS23665	COG0513	Belongs to the DEAD box helicase family
E5N77_RS23745	COG0210	DNA helicase
E5N77_RS23785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5N77_RS23835	COG3480	Lon protease (S16) C-terminal proteolytic domain
E5N77_RS23845	COG1615	UPF0182 protein
E5N77_RS23870	COG0753	catalase activity
E5N77_RS23880	COG0483	inositol monophosphate 1-phosphatase activity
E5N77_RS23895	COG1162	GTPase activity
E5N77_RS23900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5N77_RS23910	COG2135	peptidase activity
E5N77_RS23920	COG1595	DNA-templated transcription, initiation
E5N77_RS23925	COG5662	AntiSigma factor
E5N77_RS23945	COG0242	peptide deformylase activity
E5N77_RS23955	COG2124	cytochrome p450
E5N77_RS23995	COG2188	Transcriptional regulator
E5N77_RS24000	COG2182	Extracellular solute-binding protein
E5N77_RS24005	COG1175	transmembrane transport
E5N77_RS24010	COG0395	ABC-type sugar transport system, permease component
E5N77_RS24015	COG1472	Belongs to the glycosyl hydrolase 3 family
E5N77_RS24020	COG0363	glucosamine-6-phosphate deaminase activity
E5N77_RS24025	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS24045	COG1597	lipid kinase activity
E5N77_RS24075	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E5N77_RS24085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5N77_RS24090	COG0142	geranyltranstransferase activity
E5N77_RS24115	COG4106	trans-aconitate 2-methyltransferase activity
E5N77_RS24120	COG1126	abc transporter atp-binding protein
E5N77_RS24140	COG0281	malic enzyme
E5N77_RS24145	COG0604	alcohol dehydrogenase
E5N77_RS24155	COG0542	response to heat
E5N77_RS24180	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5N77_RS24180	COG0567	Dehydrogenase, E1 component
E5N77_RS24185	COG2205	protein histidine kinase activity
E5N77_RS24190	COG0745	RESPONSE REGULATOR receiver
E5N77_RS24200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5N77_RS24245	COG3883	PFAM NLP P60 protein
E5N77_RS24245	COG0791	NLP P60 protein
E5N77_RS24255	COG1309	transcriptional regulator
E5N77_RS24285	COG2205	protein histidine kinase activity
E5N77_RS24305	COG1793	dna ligase
E5N77_RS24305	COG3285	dna ligase
E5N77_RS24310	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E5N77_RS24330	COG3467	pyridoxamine 5'-phosphate
E5N77_RS24345	COG2867	negative regulation of translational initiation
E5N77_RS24350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5N77_RS24355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5N77_RS24360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5N77_RS24365	COG0662	Cupin 2, conserved barrel domain protein
E5N77_RS24370	COG2329	Antibiotic biosynthesis monooxygenase
E5N77_RS24375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5N77_RS24390	COG0513	Belongs to the DEAD box helicase family
E5N77_RS24425	COG0018	arginyl-trna synthetase
E5N77_RS24430	COG0019	diaminopimelate decarboxylase activity
E5N77_RS24435	COG0460	homoserine dehydrogenase
E5N77_RS24440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5N77_RS24445	COG0083	homoserine kinase activity
E5N77_RS24460	COG1316	TRANSCRIPTIONal
E5N77_RS24465	COG0254	rRNA binding
E5N77_RS24470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5N77_RS24475	COG2890	protein-(glutamine-N5) methyltransferase activity
E5N77_RS24485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5N77_RS24490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5N77_RS24510	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5N77_RS24515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5N77_RS24520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5N77_RS24525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5N77_RS24530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5N77_RS24535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5N77_RS24540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5N77_RS24555	COG2197	response regulator
E5N77_RS24560	COG4585	Histidine kinase
E5N77_RS24590	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5N77_RS24605	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
E5N77_RS24640	COG1131	(ABC) transporter
E5N77_RS24660	COG0183	Belongs to the thiolase family
E5N77_RS24680	COG0745	RESPONSE REGULATOR receiver
E5N77_RS24685	COG2205	protein histidine kinase activity
E5N77_RS24730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5N77_RS24730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5N77_RS24770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5N77_RS24775	COG0280	phosphate acetyltransferase
E5N77_RS24775	COG0857	belongs to the CobB CobQ family
E5N77_RS24780	COG0205	6-phosphofructokinase activity
E5N77_RS24790	COG0395	ABC-type sugar transport system, permease component
E5N77_RS24800	COG1653	transport
E5N77_RS24805	COG4565	transcriptional regulatory protein
E5N77_RS24810	COG2205	protein histidine kinase activity
E5N77_RS24810	COG4191	Histidine kinase
E5N77_RS24810	COG0745	RESPONSE REGULATOR receiver
E5N77_RS24815	COG1301	dicarboxylic acid transport
E5N77_RS24825	COG3118	belongs to the thioredoxin family
E5N77_RS24825	COG0492	ferredoxin-NADP+ reductase activity
E5N77_RS24840	COG3281	Trehalose synthase
E5N77_RS24850	COG0366	Alpha amylase catalytic
E5N77_RS24855	COG0058	SHG alpha-glucan phosphorylase activity
E5N77_RS24870	COG1132	(ABC) transporter
E5N77_RS24875	COG1132	(ABC) transporter
E5N77_RS24880	COG1132	(ABC) transporter
E5N77_RS24885	COG1132	(ABC) transporter
E5N77_RS24890	COG3119	arylsulfatase activity
E5N77_RS24905	COG1376	ErfK ybiS ycfS ynhG family protein
E5N77_RS24935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5N77_RS24940	COG3757	hydrolase, family 25
E5N77_RS24940	COG3409	Peptidoglycan-binding domain 1 protein
E5N77_RS24945	COG0477	Major facilitator Superfamily
E5N77_RS24950	COG4977	sequence-specific DNA binding
E5N77_RS24975	COG1760	l-serine dehydratase
E5N77_RS24980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5N77_RS24985	COG0509	glycine decarboxylation via glycine cleavage system
E5N77_RS24990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5N77_RS25010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5N77_RS25015	COG4166	transmembrane transport
E5N77_RS25025	COG0444	Belongs to the ABC transporter superfamily
E5N77_RS25030	COG4608	Belongs to the ABC transporter superfamily
E5N77_RS25035	COG2860	membrane
E5N77_RS25045	COG0789	Transcriptional regulator
E5N77_RS25080	COG0482	sulfurtransferase activity
E5N77_RS25095	COG1611	Belongs to the LOG family
E5N77_RS25110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5N77_RS25120	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5N77_RS25125	COG0154	amidase activity
E5N77_RS25135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5N77_RS25140	COG2409	Drug exporters of the RND superfamily
E5N77_RS25145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5N77_RS25160	COG2197	response regulator
E5N77_RS25170	COG2133	pyrroloquinoline quinone binding
E5N77_RS25175	COG0667	Aldo Keto reductase
E5N77_RS25185	COG5001	Diguanylate cyclase
E5N77_RS25195	COG0440	acetolactate synthase activity
E5N77_RS25200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5N77_RS25205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5N77_RS25215	COG0506	proline dehydrogenase activity
E5N77_RS25220	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS25230	COG0473	3-isopropylmalate dehydrogenase activity
E5N77_RS25235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5N77_RS25245	COG0832	Belongs to the urease beta subunit family
E5N77_RS25245	COG0831	urea catabolic process
E5N77_RS25250	COG0804	urea catabolic process
E5N77_RS25255	COG2957	Belongs to the agmatine deiminase family
E5N77_RS25265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5N77_RS25290	COG1335	isochorismatase
E5N77_RS25300	COG1032	radical SAM domain protein
E5N77_RS25305	COG5492	domain, Protein
E5N77_RS25310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5N77_RS25330	COG2018	Roadblock/LC7 domain
E5N77_RS25350	COG2018	Roadblock/LC7 domain
E5N77_RS25355	COG5002	protein histidine kinase activity
E5N77_RS25365	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5N77_RS25370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5N77_RS25410	COG1414	Transcriptional regulator
E5N77_RS25415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5N77_RS25420	COG0066	3-isopropylmalate dehydratase activity
E5N77_RS25430	COG0776	regulation of translation
E5N77_RS25440	COG1920	GTP binding
E5N77_RS25450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5N77_RS25455	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5N77_RS25470	COG0351	phosphomethylpyrimidine kinase
E5N77_RS25475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5N77_RS25480	COG1461	Dihydroxyacetone kinase
E5N77_RS25490	COG0742	ribosomal rna small subunit methyltransferase
E5N77_RS25495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5N77_RS25510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5N77_RS25515	COG0571	ribonuclease III activity
E5N77_RS25520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5N77_RS25525	COG1733	regulation of RNA biosynthetic process
E5N77_RS25530	COG2340	Cysteine-rich secretory protein family
E5N77_RS25535	COG1254	Belongs to the acylphosphatase family
E5N77_RS25555	COG1196	nuclear chromosome segregation
E5N77_RS25560	COG0477	Major facilitator Superfamily
E5N77_RS25595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5N77_RS25605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5N77_RS25625	COG0228	four-way junction DNA binding
E5N77_RS25630	COG1837	Belongs to the UPF0109 family
E5N77_RS25635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5N77_RS25640	COG0336	Belongs to the RNA methyltransferase TrmD family
E5N77_RS25645	COG0335	large ribosomal subunit rRNA binding
E5N77_RS25650	COG0681	Belongs to the peptidase S26 family
E5N77_RS25660	COG0681	Belongs to the peptidase S26 family
E5N77_RS25680	COG0792	nuclease activity
E5N77_RS25695	COG1191	sigma factor activity
E5N77_RS25710	COG0052	Belongs to the universal ribosomal protein uS2 family
E5N77_RS25715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5N77_RS25720	COG0528	UMP kinase activity
E5N77_RS25725	COG0233	cytoplasmic translational termination
E5N77_RS25730	COG0575	Belongs to the CDS family
E5N77_RS25735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5N77_RS25745	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E5N77_RS25750	COG3842	ATPase activity
E5N77_RS25785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E5N77_RS25795	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS25815	COG0584	glycerophosphoryl diester phosphodiesterase
E5N77_RS25820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5N77_RS25845	COG3842	ATPase activity
E5N77_RS25850	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5N77_RS25855	COG1177	transmembrane transport
E5N77_RS25860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5N77_RS25895	COG2508	Transcriptional regulator
E5N77_RS25900	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS25910	COG2226	methyltransferase
E5N77_RS25915	COG1472	Belongs to the glycosyl hydrolase 3 family
E5N77_RS25925	COG4209	transmembrane transport
E5N77_RS25930	COG0395	ABC-type sugar transport system, permease component
E5N77_RS25965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5N77_RS25970	COG0750	zinc metalloprotease
E5N77_RS25975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5N77_RS25990	COG0442	prolyl-tRNA aminoacylation
E5N77_RS26015	COG0779	Required for maturation of 30S ribosomal subunits
E5N77_RS26030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5N77_RS26040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5N77_RS26045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5N77_RS26060	COG0455	bacterial-type flagellum organization
E5N77_RS26075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5N77_RS26080	COG1185	polyribonucleotide nucleotidyltransferase activity
E5N77_RS26085	COG0612	Peptidase, M16
E5N77_RS26090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5N77_RS26110	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E5N77_RS26115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5N77_RS26120	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5N77_RS26155	COG2208	phosphoserine phosphatase activity
E5N77_RS26155	COG2770	Histidine kinase
E5N77_RS26165	COG4999	Histidine kinase
E5N77_RS26165	COG2205	protein histidine kinase activity
E5N77_RS26165	COG3850	Histidine kinase
E5N77_RS26165	COG3437	response regulator, receiver
E5N77_RS26175	COG1674	ftsk spoiiie
E5N77_RS26185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5N77_RS26195	COG1058	Belongs to the CinA family
E5N77_RS26195	COG1546	Belongs to the CinA family
E5N77_RS26200	COG1396	sequence-specific DNA binding
E5N77_RS26205	COG0783	Belongs to the Dps family
E5N77_RS26225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5N77_RS26230	COG1201	RNA secondary structure unwinding
E5N77_RS26235	COG1917	Cupin 2, conserved barrel domain protein
E5N77_RS26235	COG2207	Transcriptional regulator
E5N77_RS26260	COG0628	permease
E5N77_RS26280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5N77_RS26295	COG0765	amino acid transport
E5N77_RS26300	COG0765	amino acid transport
E5N77_RS26305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5N77_RS26310	COG1126	abc transporter atp-binding protein
E5N77_RS26315	COG0745	RESPONSE REGULATOR receiver
E5N77_RS26320	COG2205	protein histidine kinase activity
E5N77_RS26350	COG3851	Histidine kinase
E5N77_RS26355	COG2197	response regulator
E5N77_RS26360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5N77_RS26380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5N77_RS26390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5N77_RS26395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5N77_RS26405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5N77_RS26440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5N77_RS26445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5N77_RS26450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5N77_RS26465	COG0588	phosphoglycerate mutase activity
E5N77_RS26490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5N77_RS26530	COG2186	Transcriptional regulator
E5N77_RS26535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5N77_RS26550	COG0187	DNA topoisomerase II activity
E5N77_RS26560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5N77_RS26565	COG4565	transcriptional regulatory protein
E5N77_RS26570	COG3290	protein histidine kinase activity
E5N77_RS26595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5N77_RS26600	COG0612	Peptidase, M16
E5N77_RS26615	COG1802	Transcriptional regulator
E5N77_RS26620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5N77_RS26625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5N77_RS26625	COG1042	CoA-binding domain protein
E5N77_RS26625	COG0045	succinate-CoA ligase (ADP-forming) activity
E5N77_RS26640	COG1435	thymidine kinase activity
E5N77_RS26675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E5N77_RS26685	COG0745	RESPONSE REGULATOR receiver
E5N77_RS26690	COG2205	protein histidine kinase activity
E5N77_RS26715	COG0756	dUTP diphosphatase activity
E5N77_RS26725	COG1136	(ABC) transporter
E5N77_RS26725	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5N77_RS26755	COG0569	domain protein
E5N77_RS26760	COG0531	amino acid
E5N77_RS26765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5N77_RS26825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5N77_RS26880	COG3693	PFAM glycoside hydrolase, family 10
E5N77_RS26910	COG0456	acetyltransferase
E5N77_RS26920	COG0531	amino acid
E5N77_RS26935	COG0477	Major facilitator Superfamily
E5N77_RS26940	COG1122	ATPase activity
E5N77_RS26950	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
E5N77_RS26955	COG0310	cobalt ion transport
E5N77_RS26960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5N77_RS26975	COG1799	cell septum assembly
E5N77_RS26980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5N77_RS27005	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5N77_RS27015	COG2255	four-way junction helicase activity
E5N77_RS27025	COG0475	glutathione-regulated potassium exporter activity
E5N77_RS27050	COG2235	arginine
E5N77_RS27055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5N77_RS27060	COG0531	amino acid
E5N77_RS27070	COG1024	Enoyl-CoA hydratase
E5N77_RS27095	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS27130	COG4977	sequence-specific DNA binding
E5N77_RS27155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5N77_RS27165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5N77_RS27180	COG1653	transport
E5N77_RS27185	COG1175	transmembrane transport
E5N77_RS27190	COG0395	ABC-type sugar transport system, permease component
E5N77_RS27195	COG1940	carbohydrate kinase activity
E5N77_RS27200	COG4213	ABC transporter substrate-binding protein
E5N77_RS27210	COG4214	carbohydrate transport
E5N77_RS27220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5N77_RS27225	COG0531	amino acid
E5N77_RS27240	COG1316	TRANSCRIPTIONal
E5N77_RS27260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5N77_RS27260	COG1215	transferase activity, transferring glycosyl groups
E5N77_RS27265	COG2755	lipolytic protein G-D-S-L family
E5N77_RS27280	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5N77_RS27280	COG1024	Enoyl-CoA hydratase
E5N77_RS27285	COG0183	Belongs to the thiolase family
E5N77_RS27290	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E5N77_RS27305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5N77_RS27335	COG0076	glutamate decarboxylase activity
E5N77_RS27360	COG1472	Belongs to the glycosyl hydrolase 3 family
E5N77_RS27400	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5N77_RS27410	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E5N77_RS27415	COG3253	May function as heme-dependent peroxidase
E5N77_RS27430	COG3220	belongs to the UPF0276 family
E5N77_RS27455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5N77_RS27455	COG0723	plastoquinol--plastocyanin reductase activity
E5N77_RS27465	COG0330	HflC and HflK could
E5N77_RS27500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5N77_RS27505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5N77_RS27510	COG2205	protein histidine kinase activity
E5N77_RS27515	COG0745	RESPONSE REGULATOR receiver
E5N77_RS27525	COG1174	glycine betaine transport
E5N77_RS27530	COG1174	glycine betaine transport
E5N77_RS27535	COG1732	Glycine betaine
E5N77_RS27580	COG1309	transcriptional regulator
E5N77_RS27595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5N77_RS27675	COG2409	Drug exporters of the RND superfamily
E5N77_RS27695	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5N77_RS27715	COG0529	Catalyzes the synthesis of activated sulfate
E5N77_RS27720	COG0175	sulfate reduction
E5N77_RS27750	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS27765	COG4977	sequence-specific DNA binding
E5N77_RS27765	COG1917	Cupin 2, conserved barrel domain protein
E5N77_RS27785	COG1131	(ABC) transporter
E5N77_RS27825	COG0714	Associated with various cellular activities
E5N77_RS27840	COG2040	homocysteine
E5N77_RS27855	COG2197	response regulator
E5N77_RS27865	COG2755	lipolytic protein G-D-S-L family
E5N77_RS27880	COG1309	transcriptional regulator
E5N77_RS27900	COG0277	FAD linked oxidase domain protein
E5N77_RS27910	COG1162	GTPase activity
E5N77_RS27920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5N77_RS27945	COG0028	Belongs to the TPP enzyme family
E5N77_RS27965	COG1802	Transcriptional regulator
E5N77_RS27970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5N77_RS27980	COG2197	response regulator
E5N77_RS27985	COG3851	Histidine kinase
E5N77_RS28020	COG3835	regulator
E5N77_RS28030	COG2252	PERMEase
E5N77_RS28050	COG0726	polysaccharide deacetylase
E5N77_RS28060	COG2192	nodulation
E5N77_RS28070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5N77_RS28075	COG0859	PFAM glycosyl transferase family 9
E5N77_RS28080	COG0438	transferase activity, transferring glycosyl groups
E5N77_RS28085	COG0438	transferase activity, transferring glycosyl groups
E5N77_RS28090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5N77_RS28095	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E5N77_RS28095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E5N77_RS28135	COG2197	response regulator
E5N77_RS28140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5N77_RS28145	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS28155	COG3960	tartronate-semialdehyde synthase activity
E5N77_RS28170	COG0753	catalase activity
E5N77_RS28175	COG2084	Dehydrogenase
E5N77_RS28180	COG3622	Belongs to the hyi family
E5N77_RS28200	COG2351	hydroxyisourate hydrolase activity
E5N77_RS28210	COG2233	PERMEase
E5N77_RS28220	COG2233	PERMEase
E5N77_RS28235	COG0406	alpha-ribazole phosphatase activity
E5N77_RS28260	COG4264	IucA IucC family
E5N77_RS28275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5N77_RS28290	COG1414	Transcriptional regulator
E5N77_RS28295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5N77_RS28300	COG4266	Belongs to the allantoicase family
E5N77_RS28305	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS28325	COG2197	response regulator
E5N77_RS28330	COG0673	inositol 2-dehydrogenase activity
E5N77_RS28335	COG2188	Transcriptional regulator
E5N77_RS28355	COG1940	carbohydrate kinase activity
E5N77_RS28365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5N77_RS28380	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5N77_RS28385	COG3246	L-lysine catabolic process to acetate
E5N77_RS28405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5N77_RS28415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5N77_RS28430	COG2175	clavaminate synthase activity
E5N77_RS28435	COG1132	(ABC) transporter
E5N77_RS28440	COG0510	thiamine kinase activity
E5N77_RS28450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5N77_RS28480	COG2197	response regulator
E5N77_RS28485	COG4585	Histidine kinase
E5N77_RS28525	COG3629	intracellular signal transduction
E5N77_RS28525	COG3903	Transcriptional regulator
E5N77_RS28530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5N77_RS28535	COG4122	O-methyltransferase activity
E5N77_RS28540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5N77_RS28545	COG0512	Glutamine amidotransferase of anthranilate synthase
E5N77_RS28545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5N77_RS28550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5N77_RS28555	COG0134	indole-3-glycerol-phosphate synthase activity
E5N77_RS28560	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E5N77_RS28595	COG3833	ABC-type maltose transport systems, permease component
E5N77_RS28600	COG1175	transmembrane transport
E5N77_RS28615	COG1609	Transcriptional regulator
E5N77_RS28620	COG1940	carbohydrate kinase activity
E5N77_RS28625	COG1482	cell wall glycoprotein biosynthetic process
E5N77_RS28660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5N77_RS28665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5N77_RS28670	COG2080	2 iron, 2 sulfur cluster binding
E5N77_RS28680	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS28720	COG3547	Transposase (IS116 IS110 IS902 family)
E5N77_RS28745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5N77_RS28800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5N77_RS28815	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS28825	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS28830	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS28835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5N77_RS28845	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS28865	COG2072	flavoprotein involved in K transport
E5N77_RS28900	COG0464	growth
E5N77_RS28905	COG3118	belongs to the thioredoxin family
E5N77_RS28910	COG0492	ferredoxin-NADP+ reductase activity
E5N77_RS28915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5N77_RS28925	COG0798	PFAM Bile acid sodium symporter
E5N77_RS28935	COG2072	flavoprotein involved in K transport
E5N77_RS28940	COG0640	Transcriptional regulator
E5N77_RS29010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5N77_RS29010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5N77_RS29035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5N77_RS29045	COG0789	Transcriptional regulator
E5N77_RS29085	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
E5N77_RS29095	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS29100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5N77_RS29125	COG2409	Drug exporters of the RND superfamily
E5N77_RS29135	COG0745	RESPONSE REGULATOR receiver
E5N77_RS29150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5N77_RS29165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5N77_RS29170	COG0785	Cytochrome C biogenesis protein
E5N77_RS29295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5N77_RS29305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5N77_RS29310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5N77_RS29315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5N77_RS29325	COG0713	ATP synthesis coupled electron transport
E5N77_RS29330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5N77_RS29340	COG1007	ATP synthesis coupled electron transport
E5N77_RS29405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5N77_RS29420	COG0159	tryptophan synthase activity
E5N77_RS29435	COG3547	Transposase (IS116 IS110 IS902 family)
E5N77_RS29530	COG0714	Associated with various cellular activities
E5N77_RS29805	COG0494	nUDIX hydrolase
E5N77_RS29820	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS29835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5N77_RS29880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5N77_RS29930	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS29960	COG3387	PFAM Glycoside hydrolase 15-related
E5N77_RS30015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5N77_RS30020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5N77_RS30040	COG0405	Gamma-glutamyltransferase
E5N77_RS30045	COG0542	response to heat
E5N77_RS30065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5N77_RS30080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5N77_RS30090	COG1953	Uracil, thiamine, allantoin
E5N77_RS30115	COG2197	response regulator
E5N77_RS30120	COG0095	Lipoate-protein ligase
E5N77_RS30140	COG0483	inositol monophosphate 1-phosphatase activity
E5N77_RS30145	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5N77_RS30160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E5N77_RS30175	COG0601	transmembrane transport
E5N77_RS30180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5N77_RS30185	COG0444	Belongs to the ABC transporter superfamily
E5N77_RS30195	COG3540	Alkaline phosphatase
E5N77_RS30210	COG0640	Transcriptional regulator
E5N77_RS30230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5N77_RS30240	COG1929	Belongs to the glycerate kinase type-1 family
E5N77_RS30250	COG0688	phosphatidylethanolamine metabolic process
E5N77_RS30255	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS30265	COG2301	Belongs to the HpcH HpaI aldolase family
E5N77_RS30270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5N77_RS30270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5N77_RS30275	COG0604	alcohol dehydrogenase
E5N77_RS30285	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5N77_RS30300	COG0596	Alpha beta hydrolase
E5N77_RS30320	COG2172	sigma factor antagonist activity
E5N77_RS30320	COG1366	Belongs to the anti-sigma-factor antagonist family
E5N77_RS30320	COG2208	phosphoserine phosphatase activity
E5N77_RS30325	COG2226	methyltransferase
E5N77_RS30330	COG2362	D-Aminopeptidase
E5N77_RS30335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5N77_RS30345	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5N77_RS30375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5N77_RS30390	COG1793	dna ligase
E5N77_RS30390	COG3285	dna ligase
E5N77_RS30455	COG1597	lipid kinase activity
E5N77_RS30475	COG0693	protein deglycase activity
E5N77_RS30485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5N77_RS30540	COG0531	amino acid
E5N77_RS30570	COG1140	nitrate reductase beta subunit
E5N77_RS30600	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5N77_RS30605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E5N77_RS30605	COG4106	trans-aconitate 2-methyltransferase activity
E5N77_RS30610	COG3401	FG-GAP repeat protein
E5N77_RS30625	COG5297	Belongs to the glycosyl hydrolase family 6
E5N77_RS30625	COG4733	cellulase activity
E5N77_RS30635	COG5297	Belongs to the glycosyl hydrolase family 6
E5N77_RS30645	COG0656	L-ascorbic acid biosynthetic process
E5N77_RS30670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5N77_RS30680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5N77_RS30685	COG3383	formate dehydrogenase (NAD+) activity
E5N77_RS30690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5N77_RS30700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5N77_RS30715	COG1129	ABC transporter
E5N77_RS30720	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5N77_RS30730	COG0673	inositol 2-dehydrogenase activity
E5N77_RS30750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5N77_RS30785	COG2223	nitrite transmembrane transporter activity
E5N77_RS30795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5N77_RS30805	COG0045	succinate-CoA ligase (ADP-forming) activity
E5N77_RS30815	COG1012	belongs to the aldehyde dehydrogenase family
E5N77_RS30830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5N77_RS30850	COG0714	Associated with various cellular activities
E5N77_RS30855	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E5N77_RS30870	COG4632	Exopolysaccharide biosynthesis protein
E5N77_RS30870	COG5434	Belongs to the glycosyl hydrolase 28 family
E5N77_RS30890	COG0210	DNA helicase
E5N77_RS30905	COG0747	negative chemotaxis
E5N77_RS30910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5N77_RS30935	COG0297	glycogen (starch) synthase activity
E5N77_RS30950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5N77_RS30970	COG0477	Major facilitator Superfamily
E5N77_RS30980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5N77_RS30985	COG1082	Xylose isomerase domain protein TIM barrel
E5N77_RS30985	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E5N77_RS30995	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E5N77_RS31000	COG0166	Belongs to the GPI family
E5N77_RS31015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5N77_RS31045	COG1486	melibiose metabolic process
E5N77_RS31055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5N77_RS31085	COG0477	Major facilitator Superfamily
E5N77_RS31090	COG3511	phospholipase C
E5N77_RS31120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5N77_RS31125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5N77_RS31130	COG3485	protocatechuate 3,4-dioxygenase
E5N77_RS31135	COG3485	protocatechuate 3,4-dioxygenase
E5N77_RS31140	COG0183	Belongs to the thiolase family
E5N77_RS31160	COG1470	cell adhesion involved in biofilm formation
E5N77_RS31170	COG1793	dna ligase
E5N77_RS31175	COG0488	(ABC) transporter
E5N77_RS31215	COG1834	amidinotransferase
E5N77_RS31220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5N77_RS31225	COG0488	(ABC) transporter
E5N77_RS31250	COG1515	deoxyribonuclease V activity
E5N77_RS31265	COG3268	Saccharopine dehydrogenase
E5N77_RS31270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5N77_RS31275	COG0183	Belongs to the thiolase family
E5N77_RS31280	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5N77_RS31280	COG1024	Enoyl-CoA hydratase
E5N77_RS31295	COG1113	amino acid transport
E5N77_RS31310	COG2936	dipeptidyl-peptidase activity
E5N77_RS31320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5N77_RS31340	COG0488	(ABC) transporter
E5N77_RS31365	COG1024	Enoyl-CoA hydratase
E5N77_RS31375	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E5N77_RS31420	COG1134	teichoic acid transport
E5N77_RS31425	COG1562	ergosterol biosynthetic process
E5N77_RS31435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E5N77_RS31445	COG1657	PFAM Prenyltransferase squalene oxidase
E5N77_RS31460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5N77_RS31465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5N77_RS31485	COG2365	Tyrosine phosphatase family
E5N77_RS31495	COG2755	lipolytic protein G-D-S-L family
E5N77_RS31540	COG1063	alcohol dehydrogenase
E5N77_RS31545	COG0156	8-amino-7-oxononanoate synthase activity
E5N77_RS31550	COG0583	DNA-binding transcription factor activity
E5N77_RS31580	COG2111	Na H antiporter
E5N77_RS31580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5N77_RS31585	COG1006	Multisubunit Na H antiporter MnhC subunit
E5N77_RS31590	COG0651	ATP synthesis coupled electron transport
E5N77_RS31605	COG1320	monovalent cation:proton antiporter activity
E5N77_RS31620	COG0174	glutamine synthetase
E5N77_RS31640	COG2267	carboxylic ester hydrolase activity
E5N77_RS31645	COG0183	Belongs to the thiolase family
E5N77_RS31650	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS31690	COG0494	nUDIX hydrolase
E5N77_RS31695	COG2188	Transcriptional regulator
E5N77_RS31700	COG3962	Belongs to the TPP enzyme family
E5N77_RS31705	COG3718	enzyme involved in inositol metabolism
E5N77_RS31715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5N77_RS31740	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E5N77_RS31745	COG0673	inositol 2-dehydrogenase activity
E5N77_RS31750	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS31760	COG1609	Transcriptional regulator
E5N77_RS31770	COG0673	inositol 2-dehydrogenase activity
E5N77_RS31780	COG0385	Bile acid
E5N77_RS31795	COG2197	response regulator
E5N77_RS31820	COG2124	cytochrome p450
E5N77_RS31830	COG2838	Isocitrate dehydrogenase
E5N77_RS31835	COG0668	transmembrane transport
E5N77_RS31845	COG1132	(ABC) transporter
E5N77_RS31855	COG0366	Alpha amylase catalytic
E5N77_RS31860	COG0395	ABC-type sugar transport system, permease component
E5N77_RS31865	COG1175	transmembrane transport
E5N77_RS31870	COG1653	transport
E5N77_RS31895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5N77_RS31915	COG3938	Belongs to the proline racemase family
E5N77_RS31920	COG1802	Transcriptional regulator
E5N77_RS31925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS31930	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E5N77_RS31940	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5N77_RS31945	COG4106	trans-aconitate 2-methyltransferase activity
E5N77_RS31955	COG2267	carboxylic ester hydrolase activity
E5N77_RS31960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5N77_RS31970	COG0019	diaminopimelate decarboxylase activity
E5N77_RS31980	COG4865	methylaspartate mutase activity
E5N77_RS31990	COG0477	Major facilitator Superfamily
E5N77_RS32020	COG0667	Aldo Keto reductase
E5N77_RS32050	COG3321	synthase
E5N77_RS32050	COG0604	alcohol dehydrogenase
E5N77_RS32055	COG0604	alcohol dehydrogenase
E5N77_RS32055	COG3321	synthase
E5N77_RS32120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E5N77_RS32140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E5N77_RS32165	COG0297	glycogen (starch) synthase activity
E5N77_RS32170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5N77_RS32210	COG1609	Transcriptional regulator
E5N77_RS32215	COG1653	transport
E5N77_RS32220	COG1175	transmembrane transport
E5N77_RS32225	COG0395	ABC-type sugar transport system, permease component
E5N77_RS32255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5N77_RS32290	COG0531	amino acid
E5N77_RS32300	COG0726	polysaccharide deacetylase
E5N77_RS32345	COG0583	DNA-binding transcription factor activity
E5N77_RS32355	COG1053	succinate dehydrogenase
E5N77_RS32360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5N77_RS32385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5N77_RS32395	COG3360	Dodecin
E5N77_RS32410	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E5N77_RS32415	COG0121	glutamine amidotransferase
E5N77_RS32420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5N77_RS32430	COG3572	ergothioneine biosynthetic process
E5N77_RS32470	COG0596	Alpha beta hydrolase
E5N77_RS32475	COG3903	Transcriptional regulator
E5N77_RS32475	COG3629	intracellular signal transduction
E5N77_RS32495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5N77_RS32500	COG3976	FMN-binding domain protein
E5N77_RS32500	COG1053	succinate dehydrogenase
E5N77_RS32520	COG0583	DNA-binding transcription factor activity
E5N77_RS32535	COG1609	Transcriptional regulator
E5N77_RS32540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5N77_RS32550	COG0242	peptide deformylase activity
E5N77_RS32570	COG1683	Conserved Protein
E5N77_RS32610	COG1846	Transcriptional regulator
E5N77_RS32615	COG2409	Drug exporters of the RND superfamily
E5N77_RS32630	COG0668	transmembrane transport
E5N77_RS32670	COG3540	Alkaline phosphatase
E5N77_RS32695	COG1136	(ABC) transporter
E5N77_RS32695	COG0577	efflux transmembrane transporter activity
E5N77_RS32700	COG1556	Lactate utilization protein
E5N77_RS32705	COG1139	Iron-sulfur cluster binding protein
E5N77_RS32710	COG0247	lactate metabolic process
E5N77_RS32715	COG1070	Carbohydrate kinase
E5N77_RS32720	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS32720	COG3347	Dehydrogenase
E5N77_RS32725	COG4952	isomerase
E5N77_RS32730	COG1129	ABC transporter
E5N77_RS32735	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5N77_RS32755	COG1609	Transcriptional regulator
E5N77_RS32770	COG1357	PFAM Pentapeptide repeats (8 copies)
E5N77_RS32780	COG1309	transcriptional regulator
E5N77_RS32825	COG1796	DNA polymerase
E5N77_RS32825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5N77_RS32830	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS32860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5N77_RS32900	COG2124	cytochrome p450
E5N77_RS32920	COG0435	Glutathione S-transferase
E5N77_RS32935	COG2124	cytochrome p450
E5N77_RS32950	COG0667	Aldo Keto reductase
E5N77_RS32985	COG1304	FMN binding
E5N77_RS33000	COG2890	protein-(glutamine-N5) methyltransferase activity
E5N77_RS33015	COG0248	Ppx GppA phosphatase
E5N77_RS33055	COG0517	IMP dehydrogenase activity
E5N77_RS33095	COG1132	(ABC) transporter
E5N77_RS33125	COG2182	Extracellular solute-binding protein
E5N77_RS33130	COG0395	ABC-type sugar transport system, permease component
E5N77_RS33135	COG1175	transmembrane transport
E5N77_RS33140	COG1846	Transcriptional regulator
E5N77_RS33140	COG1940	carbohydrate kinase activity
E5N77_RS33170	COG1309	transcriptional regulator
E5N77_RS33195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5N77_RS33245	COG0673	inositol 2-dehydrogenase activity
E5N77_RS33260	COG2508	Transcriptional regulator
E5N77_RS33265	COG0410	ABC transporter
E5N77_RS33270	COG0411	ABC transporter
E5N77_RS33315	COG1132	(ABC) transporter
E5N77_RS33360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5N77_RS33365	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5N77_RS33370	COG2080	2 iron, 2 sulfur cluster binding
E5N77_RS33380	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS33385	COG1295	ribonuclease BN
E5N77_RS33415	COG0477	Major facilitator Superfamily
E5N77_RS33430	COG3290	protein histidine kinase activity
E5N77_RS33470	COG0277	FAD linked oxidase domain protein
E5N77_RS33475	COG1597	lipid kinase activity
E5N77_RS33500	COG0395	ABC-type sugar transport system, permease component
E5N77_RS33505	COG1175	transmembrane transport
E5N77_RS33515	COG1609	Transcriptional regulator
E5N77_RS33575	COG2264	protein methyltransferase activity
E5N77_RS33580	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS33610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5N77_RS33620	COG4608	Belongs to the ABC transporter superfamily
E5N77_RS33640	COG3397	chitin binding
E5N77_RS33665	COG0488	(ABC) transporter
E5N77_RS33685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5N77_RS33690	COG1937	Protein conserved in bacteria
E5N77_RS33695	COG0730	response to heat
E5N77_RS33705	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E5N77_RS33730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5N77_RS33740	COG2235	arginine
E5N77_RS33795	COG0505	Belongs to the CarA family
E5N77_RS33825	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E5N77_RS33830	COG1191	sigma factor activity
E5N77_RS33850	COG0783	Belongs to the Dps family
E5N77_RS33855	COG0655	NAD(P)H dehydrogenase (quinone) activity
E5N77_RS33895	COG4232	protein-disulfide reductase activity
E5N77_RS33900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5N77_RS33900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5N77_RS33920	COG2018	Roadblock/LC7 domain
E5N77_RS33935	COG2124	cytochrome p450
E5N77_RS33940	COG2124	cytochrome p450
E5N77_RS33950	COG2186	Transcriptional regulator
E5N77_RS33960	COG2376	Dihydroxyacetone kinase
E5N77_RS33965	COG0698	ribose 5-phosphate isomerase
E5N77_RS33970	COG0149	triose-phosphate isomerase activity
E5N77_RS33975	COG1082	Xylose isomerase domain protein TIM barrel
E5N77_RS33980	COG2084	Dehydrogenase
E5N77_RS33985	COG3340	Belongs to the peptidase S51 family
E5N77_RS34000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E5N77_RS34005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5N77_RS34010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5N77_RS34015	COG0142	geranyltranstransferase activity
E5N77_RS34025	COG0142	geranyltranstransferase activity
E5N77_RS34065	COG0789	Transcriptional regulator
E5N77_RS34100	COG0745	RESPONSE REGULATOR receiver
E5N77_RS34105	COG2205	protein histidine kinase activity
E5N77_RS34110	COG2340	Cysteine-rich secretory protein family
E5N77_RS34115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5N77_RS34120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5N77_RS34135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5N77_RS34160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5N77_RS34165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5N77_RS34175	COG0438	transferase activity, transferring glycosyl groups
E5N77_RS34195	COG0667	Aldo Keto reductase
E5N77_RS34210	COG0741	lytic transglycosylase activity
E5N77_RS34210	COG1196	nuclear chromosome segregation
E5N77_RS34210	COG0739	heme binding
E5N77_RS34220	COG1309	transcriptional regulator
E5N77_RS34225	COG0318	PFAM AMP-dependent synthetase and ligase
E5N77_RS34230	COG1960	acyl-CoA dehydrogenase activity
E5N77_RS34235	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E5N77_RS34255	COG0673	inositol 2-dehydrogenase activity
E5N77_RS34265	COG1278	Cold shock
E5N77_RS34280	COG3386	PFAM SMP-30 Gluconolaconase
E5N77_RS34295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5N77_RS34305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5N77_RS34325	COG0583	DNA-binding transcription factor activity
E5N77_RS34340	COG3486	L-lysine 6-monooxygenase (NADPH) activity
E5N77_RS34345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS34350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS34355	COG1120	ATPase activity
E5N77_RS34360	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E5N77_RS34365	COG1132	(ABC) transporter
E5N77_RS34375	COG1132	(ABC) transporter
E5N77_RS34380	COG2382	esterase
E5N77_RS34405	COG4106	trans-aconitate 2-methyltransferase activity
E5N77_RS34415	COG0477	Major facilitator Superfamily
E5N77_RS34430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5N77_RS34445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5N77_RS34525	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E5N77_RS34535	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS34540	COG0667	Aldo Keto reductase
E5N77_RS34545	COG1470	cell adhesion involved in biofilm formation
E5N77_RS34545	COG0366	Alpha amylase catalytic
E5N77_RS34550	COG1609	Transcriptional regulator
E5N77_RS34575	COG2375	cellular response to nickel ion
E5N77_RS34600	COG1984	allophanate hydrolase subunit 2
E5N77_RS34605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E5N77_RS34610	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E5N77_RS34625	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E5N77_RS34635	COG0667	Aldo Keto reductase
E5N77_RS34640	COG2770	Histidine kinase
E5N77_RS34640	COG2208	phosphoserine phosphatase activity
E5N77_RS34645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5N77_RS34660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5N77_RS34665	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
E5N77_RS34675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5N77_RS34685	COG2814	Major facilitator Superfamily
E5N77_RS34690	COG0384	phenazine biosynthesis protein PhzF
E5N77_RS34695	COG1609	Transcriptional regulator
E5N77_RS34705	COG0402	S-adenosylhomocysteine deaminase activity
E5N77_RS34735	COG4221	oxidoreductase activity
E5N77_RS34765	COG1595	DNA-templated transcription, initiation
E5N77_RS34795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS34800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E5N77_RS34830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5N77_RS34840	COG0302	gtp cyclohydrolase
E5N77_RS34855	COG0667	Aldo Keto reductase
E5N77_RS34875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5N77_RS34880	COG0739	heme binding
E5N77_RS34905	COG0583	DNA-binding transcription factor activity
E5N77_RS34930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5N77_RS34935	COG0747	negative chemotaxis
E5N77_RS34965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5N77_RS34970	COG1021	2,3-dihydroxybenzoate-AMP ligase
E5N77_RS34975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5N77_RS34975	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
E5N77_RS34980	COG3433	isochorismatase activity
E5N77_RS34980	COG2226	methyltransferase
E5N77_RS34980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5N77_RS35010	COG2375	cellular response to nickel ion
E5N77_RS35010	COG1132	(ABC) transporter
E5N77_RS35015	COG1132	(ABC) transporter
E5N77_RS35020	COG1169	isochorismate synthase
E5N77_RS35030	COG0523	cobalamin synthesis protein
E5N77_RS35040	COG0778	Nitroreductase
E5N77_RS35150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5N77_RS35165	COG2723	6-phospho-beta-galactosidase activity
E5N77_RS35170	COG3833	ABC-type maltose transport systems, permease component
E5N77_RS35175	COG1175	transmembrane transport
E5N77_RS35180	COG2182	Extracellular solute-binding protein
E5N77_RS35235	COG2197	response regulator
E5N77_RS35240	COG1132	(ABC) transporter
E5N77_RS35245	COG1132	(ABC) transporter
E5N77_RS35255	COG0515	serine threonine protein kinase
E5N77_RS35295	COG3226	Transcriptional regulator
E5N77_RS35300	COG0738	Major facilitator superfamily
E5N77_RS35315	COG4221	oxidoreductase activity
E5N77_RS35320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5N77_RS35350	COG0583	DNA-binding transcription factor activity
E5N77_RS35355	COG1136	(ABC) transporter
E5N77_RS35400	COG2814	Major facilitator Superfamily
E5N77_RS35405	COG4585	Histidine kinase
E5N77_RS35410	COG2197	response regulator
E5N77_RS35420	COG0745	RESPONSE REGULATOR receiver
E5N77_RS35425	COG5002	protein histidine kinase activity
E5N77_RS35440	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E5N77_RS35460	COG1309	transcriptional regulator
E5N77_RS35465	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS35470	COG1028	Short-chain dehydrogenase reductase Sdr
E5N77_RS35510	COG2223	nitrite transmembrane transporter activity
E5N77_RS35530	COG2205	protein histidine kinase activity
E5N77_RS35535	COG0745	RESPONSE REGULATOR receiver
E5N77_RS35545	COG1131	(ABC) transporter
E5N77_RS35560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS35565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5N77_RS35570	COG1120	ATPase activity
E5N77_RS35575	COG1132	(ABC) transporter
E5N77_RS35580	COG1132	(ABC) transporter
E5N77_RS35605	COG2208	phosphoserine phosphatase activity
E5N77_RS35605	COG2770	Histidine kinase
E5N77_RS35610	COG1366	Belongs to the anti-sigma-factor antagonist family
E5N77_RS35620	COG1191	sigma factor activity
E5N77_RS35705	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5N77_RS35745	COG0583	DNA-binding transcription factor activity
E5N77_RS35785	COG2197	response regulator
E5N77_RS35790	COG4585	Histidine kinase
E5N77_RS35800	COG0577	efflux transmembrane transporter activity
E5N77_RS35800	COG1136	(ABC) transporter
E5N77_RS35810	COG0477	Major facilitator Superfamily
E5N77_RS35820	COG1609	Transcriptional regulator
E5N77_RS35840	COG4585	Histidine kinase
E5N77_RS35845	COG2197	response regulator
E5N77_RS35855	COG1132	(ABC) transporter
E5N77_RS35880	COG3250	beta-galactosidase activity
E5N77_RS35885	COG0395	ABC-type sugar transport system, permease component
E5N77_RS35890	COG1175	transmembrane transport
E5N77_RS35900	COG1609	Transcriptional regulator
E5N77_RS35930	COG0300	oxidoreductase activity
E5N77_RS35945	COG0583	DNA-binding transcription factor activity
E5N77_RS35965	COG0604	alcohol dehydrogenase
E5N77_RS36050	COG0537	adenosine 5'-monophosphoramidase activity
E5N77_RS36080	COG2226	methyltransferase
E5N77_RS36095	COG1063	alcohol dehydrogenase
E5N77_RS36110	COG0300	oxidoreductase activity
E5N77_RS36165	COG2828	Protein conserved in bacteria
E5N77_RS36220	COG1857	crispr-associated protein
E5N77_RS36255	COG1414	Transcriptional regulator
E5N77_RS36260	COG0477	Major facilitator Superfamily
E5N77_RS36265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5N77_RS36270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5N77_RS36290	COG0583	DNA-binding transcription factor activity
E5N77_RS36515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5N77_RS36530	COG1902	pentaerythritol trinitrate reductase activity
E5N77_RS36535	COG0604	alcohol dehydrogenase