locus-tag	class	description
K9S39_RS00160	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K9S39_RS00210	COG0583	DNA-binding transcription factor activity
K9S39_RS00215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K9S39_RS00230	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9S39_RS00235	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS00250	COG1733	regulation of RNA biosynthetic process
K9S39_RS00270	COG0513	Belongs to the DEAD box helicase family
K9S39_RS00275	COG1278	Cold shock
K9S39_RS00295	COG2814	Major facilitator Superfamily
K9S39_RS00315	COG0583	DNA-binding transcription factor activity
K9S39_RS00365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K9S39_RS00370	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K9S39_RS00455	COG1278	Cold shock
K9S39_RS00475	COG0300	oxidoreductase activity
K9S39_RS00490	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS00505	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS00525	COG0477	Major facilitator Superfamily
K9S39_RS00555	COG0477	Major facilitator Superfamily
K9S39_RS00585	COG0142	geranyltranstransferase activity
K9S39_RS00620	COG1228	amidohydrolase
K9S39_RS00640	COG0156	8-amino-7-oxononanoate synthase activity
K9S39_RS00655	COG0604	alcohol dehydrogenase
K9S39_RS00655	COG3321	synthase
K9S39_RS00660	COG0604	alcohol dehydrogenase
K9S39_RS00660	COG3321	synthase
K9S39_RS00670	COG0604	alcohol dehydrogenase
K9S39_RS00670	COG3321	synthase
K9S39_RS00680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K9S39_RS00685	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K9S39_RS00695	COG2124	cytochrome p450
K9S39_RS00740	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS00755	COG0829	nickel cation binding
K9S39_RS00760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K9S39_RS00770	COG0804	urea catabolic process
K9S39_RS00775	COG0832	Belongs to the urease beta subunit family
K9S39_RS00775	COG0831	urea catabolic process
K9S39_RS00810	COG0277	FAD linked oxidase domain protein
K9S39_RS00835	COG0142	geranyltranstransferase activity
K9S39_RS00840	COG2409	Drug exporters of the RND superfamily
K9S39_RS00850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K9S39_RS00880	COG3573	Dehydrogenase
K9S39_RS00955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K9S39_RS00970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K9S39_RS00975	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K9S39_RS01045	COG0028	Belongs to the TPP enzyme family
K9S39_RS01050	COG0277	FAD linked oxidase domain protein
K9S39_RS01050	COG0247	lactate metabolic process
K9S39_RS01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K9S39_RS01250	COG0688	phosphatidylethanolamine metabolic process
K9S39_RS01260	COG1595	DNA-templated transcription, initiation
K9S39_RS01285	COG1063	alcohol dehydrogenase
K9S39_RS01310	COG2409	Drug exporters of the RND superfamily
K9S39_RS01335	COG4585	Histidine kinase
K9S39_RS01415	COG1595	DNA-templated transcription, initiation
K9S39_RS01580	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K9S39_RS01585	COG1518	maintenance of DNA repeat elements
K9S39_RS01675	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS01715	COG2409	Drug exporters of the RND superfamily
K9S39_RS01720	COG2409	Drug exporters of the RND superfamily
K9S39_RS01785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K9S39_RS01795	COG1247	-acetyltransferase
K9S39_RS01800	COG0640	Transcriptional regulator
K9S39_RS01855	COG0443	Heat shock 70 kDa protein
K9S39_RS01875	COG0395	ABC-type sugar transport system, permease component
K9S39_RS01910	COG1695	Transcriptional regulator
K9S39_RS01950	COG1285	pathogenesis
K9S39_RS01960	COG1116	anion transmembrane transporter activity
K9S39_RS01965	COG0640	Transcriptional regulator
K9S39_RS01980	COG0640	Transcriptional regulator
K9S39_RS02065	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS02075	COG1982	Orn Lys Arg decarboxylase major
K9S39_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS02110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K9S39_RS02120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K9S39_RS02165	COG0789	Transcriptional regulator
K9S39_RS02200	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K9S39_RS02200	COG3608	succinylglutamate desuccinylase aspartoacylase
K9S39_RS02205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9S39_RS02210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K9S39_RS02215	COG2080	2 iron, 2 sulfur cluster binding
K9S39_RS02245	COG3848	Pyruvate phosphate dikinase
K9S39_RS02245	COG0574	Belongs to the PEP-utilizing enzyme family
K9S39_RS02255	COG0789	Transcriptional regulator
K9S39_RS02275	COG0477	Major facilitator Superfamily
K9S39_RS02285	COG0156	8-amino-7-oxononanoate synthase activity
K9S39_RS02290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K9S39_RS02300	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K9S39_RS02310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K9S39_RS02330	COG1819	glycosyl
K9S39_RS02355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9S39_RS02385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9S39_RS02390	COG0596	Alpha beta hydrolase
K9S39_RS02395	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS02400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9S39_RS02410	COG1309	transcriptional regulator
K9S39_RS02415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K9S39_RS02440	COG0738	Major facilitator superfamily
K9S39_RS02450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K9S39_RS02455	COG3290	protein histidine kinase activity
K9S39_RS02460	COG1169	isochorismate synthase
K9S39_RS02490	COG2226	methyltransferase
K9S39_RS02500	COG1473	amidohydrolase
K9S39_RS02560	COG2814	Major facilitator Superfamily
K9S39_RS02565	COG1349	DNA-binding transcription factor activity
K9S39_RS02570	COG1063	alcohol dehydrogenase
K9S39_RS02575	COG1070	Carbohydrate kinase
K9S39_RS02610	COG3290	protein histidine kinase activity
K9S39_RS02630	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS02645	COG1793	dna ligase
K9S39_RS02700	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K9S39_RS02725	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS02735	COG2124	cytochrome p450
K9S39_RS02740	COG2084	Dehydrogenase
K9S39_RS02745	COG3622	Belongs to the hyi family
K9S39_RS02750	COG3960	tartronate-semialdehyde synthase activity
K9S39_RS02755	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS02765	COG0242	peptide deformylase activity
K9S39_RS02775	COG3442	glutamine amidotransferase
K9S39_RS02780	COG0205	6-phosphofructokinase activity
K9S39_RS02800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K9S39_RS02805	COG0508	dehydrogenase complex catalyzes the overall conversion of
K9S39_RS02880	COG0829	nickel cation binding
K9S39_RS02885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K9S39_RS02890	COG0830	nickel cation binding
K9S39_RS02895	COG0804	urea catabolic process
K9S39_RS02900	COG0832	Belongs to the urease beta subunit family
K9S39_RS02905	COG0831	urea catabolic process
K9S39_RS02910	COG2234	aminopeptidase activity
K9S39_RS02910	COG4935	Belongs to the peptidase S8 family
K9S39_RS02920	COG0740	serine-type endopeptidase activity
K9S39_RS02950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K9S39_RS02955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K9S39_RS02960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K9S39_RS03005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K9S39_RS03010	COG3663	DNA glycosylase
K9S39_RS03020	COG1940	carbohydrate kinase activity
K9S39_RS03025	COG2188	Transcriptional regulator
K9S39_RS03035	COG1595	DNA-templated transcription, initiation
K9S39_RS03040	COG2267	carboxylic ester hydrolase activity
K9S39_RS03090	COG1522	sequence-specific DNA binding
K9S39_RS03095	COG0419	ATPase involved in DNA repair
K9S39_RS03100	COG0420	3'-5' exonuclease activity
K9S39_RS03105	COG1739	Uncharacterized protein family UPF0029
K9S39_RS03130	COG1832	CoA-binding protein
K9S39_RS03165	COG2124	cytochrome p450
K9S39_RS03230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K9S39_RS03250	COG1968	undecaprenyl-diphosphatase activity
K9S39_RS03270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9S39_RS03275	COG2364	Membrane
K9S39_RS03300	COG2223	nitrite transmembrane transporter activity
K9S39_RS03310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K9S39_RS03325	COG0045	succinate-CoA ligase (ADP-forming) activity
K9S39_RS03460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K9S39_RS03550	COG1999	signal sequence binding
K9S39_RS03620	COG3387	PFAM Glycoside hydrolase 15-related
K9S39_RS03680	COG2132	Multicopper oxidase
K9S39_RS03710	COG4974	Belongs to the 'phage' integrase family
K9S39_RS03805	COG4264	IucA IucC family
K9S39_RS03855	COG2226	methyltransferase
K9S39_RS03865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K9S39_RS03880	COG3594	Acyltransferase
K9S39_RS03900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K9S39_RS03925	COG0745	RESPONSE REGULATOR receiver
K9S39_RS03930	COG2205	protein histidine kinase activity
K9S39_RS03995	COG0542	response to heat
K9S39_RS04010	COG0085	RNA polymerase activity
K9S39_RS04060	COG4716	Myosin-crossreactive antigen
K9S39_RS04100	COG2890	protein-(glutamine-N5) methyltransferase activity
K9S39_RS04155	COG0789	Transcriptional regulator
K9S39_RS04220	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS04270	COG1597	lipid kinase activity
K9S39_RS04295	COG0659	secondary active sulfate transmembrane transporter activity
K9S39_RS04330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K9S39_RS04450	COG1074	ATP-dependent DNA helicase activity
K9S39_RS04460	COG0542	response to heat
K9S39_RS04790	COG3387	PFAM Glycoside hydrolase 15-related
K9S39_RS04985	COG2186	Transcriptional regulator
K9S39_RS04995	COG1942	4-Oxalocrotonate Tautomerase
K9S39_RS05005	COG2814	Major facilitator Superfamily
K9S39_RS05035	COG0187	DNA topoisomerase II activity
K9S39_RS05110	COG3415	Transposase
K9S39_RS05115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K9S39_RS05130	COG4257	antibiotic catabolic process
K9S39_RS05235	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K9S39_RS05400	COG0587	DNA-directed DNA polymerase activity
K9S39_RS05425	COG2801	Transposase and inactivated derivatives
K9S39_RS05440	COG2801	Transposase and inactivated derivatives
K9S39_RS05455	COG2409	Drug exporters of the RND superfamily
K9S39_RS05470	COG2124	cytochrome p450
K9S39_RS05500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K9S39_RS05560	COG1674	ftsk spoiiie
K9S39_RS05625	COG0242	peptide deformylase activity
K9S39_RS05645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K9S39_RS05960	COG0515	serine threonine protein kinase
K9S39_RS06035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K9S39_RS06050	COG2133	pyrroloquinoline quinone binding
K9S39_RS06155	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS06190	COG1131	(ABC) transporter
K9S39_RS06200	COG2197	response regulator
K9S39_RS06215	COG2223	nitrite transmembrane transporter activity
K9S39_RS06225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K9S39_RS06240	COG0045	succinate-CoA ligase (ADP-forming) activity
K9S39_RS06285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K9S39_RS06365	COG0582	viral genome integration into host DNA
K9S39_RS06435	COG0492	ferredoxin-NADP+ reductase activity
K9S39_RS06440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K9S39_RS06460	COG0798	PFAM Bile acid sodium symporter
K9S39_RS06465	COG2072	flavoprotein involved in K transport
K9S39_RS06470	COG0789	Transcriptional regulator
K9S39_RS06475	COG0640	Transcriptional regulator
K9S39_RS06535	COG4335	DNA alkylation repair
K9S39_RS06540	COG0477	Major facilitator Superfamily
K9S39_RS06560	COG0659	secondary active sulfate transmembrane transporter activity
K9S39_RS06580	COG3385	transposase activity
K9S39_RS06620	COG0584	glycerophosphoryl diester phosphodiesterase
K9S39_RS06655	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
K9S39_RS06655	COG1672	PFAM Archaeal ATPase
K9S39_RS06665	COG0477	Major facilitator Superfamily
K9S39_RS06670	COG0247	lactate metabolic process
K9S39_RS06675	COG1139	Iron-sulfur cluster binding protein
K9S39_RS06680	COG1556	Lactate utilization protein
K9S39_RS06690	COG1132	(ABC) transporter
K9S39_RS06730	COG1946	Acyl-CoA thioesterase
K9S39_RS06755	COG2018	Roadblock/LC7 domain
K9S39_RS06935	COG0791	NLP P60 protein
K9S39_RS07140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K9S39_RS07150	COG2040	homocysteine
K9S39_RS07155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K9S39_RS07160	COG0765	amino acid transport
K9S39_RS07175	COG3458	cephalosporin-C deacetylase activity
K9S39_RS07185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9S39_RS07190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9S39_RS07190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9S39_RS07195	COG3023	N-Acetylmuramoyl-L-alanine amidase
K9S39_RS07220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K9S39_RS07220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K9S39_RS07230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K9S39_RS07235	COG0588	phosphoglycerate mutase activity
K9S39_RS07240	COG1070	Carbohydrate kinase
K9S39_RS07250	COG2814	Major facilitator Superfamily
K9S39_RS07255	COG1349	DNA-binding transcription factor activity
K9S39_RS07275	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS07280	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS07305	COG3572	ergothioneine biosynthetic process
K9S39_RS07310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K9S39_RS07320	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K9S39_RS07355	COG3360	Dodecin
K9S39_RS07360	COG0531	amino acid
K9S39_RS07370	COG3537	Alpha-1,2-mannosidase
K9S39_RS07405	COG0149	triose-phosphate isomerase activity
K9S39_RS07410	COG0698	ribose 5-phosphate isomerase
K9S39_RS07415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K9S39_RS07425	COG1063	alcohol dehydrogenase
K9S39_RS07455	COG2706	6-phosphogluconolactonase activity
K9S39_RS07460	COG4552	Acetyltransferase involved in intracellular survival and related
K9S39_RS07465	COG1652	LysM domain
K9S39_RS07475	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS07500	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS07510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K9S39_RS07520	COG0747	negative chemotaxis
K9S39_RS07525	COG1940	carbohydrate kinase activity
K9S39_RS07525	COG1846	Transcriptional regulator
K9S39_RS07575	COG0174	glutamine synthetase
K9S39_RS07620	COG1686	Belongs to the peptidase S11 family
K9S39_RS07655	COG3959	Transketolase, thiamine diphosphate binding domain
K9S39_RS07660	COG3958	Transketolase
K9S39_RS07665	COG2267	carboxylic ester hydrolase activity
K9S39_RS07670	COG0402	S-adenosylhomocysteine deaminase activity
K9S39_RS07675	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS07695	COG2018	Roadblock/LC7 domain
K9S39_RS07720	COG1278	Cold shock
K9S39_RS07830	COG2755	lipolytic protein G-D-S-L family
K9S39_RS07835	COG2365	Tyrosine phosphatase family
K9S39_RS07850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K9S39_RS07865	COG1657	PFAM Prenyltransferase squalene oxidase
K9S39_RS07875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K9S39_RS07885	COG1562	ergosterol biosynthetic process
K9S39_RS07890	COG1134	teichoic acid transport
K9S39_RS07925	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K9S39_RS07955	COG4977	sequence-specific DNA binding
K9S39_RS07965	COG2183	response to ionizing radiation
K9S39_RS07985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K9S39_RS07995	COG2936	dipeptidyl-peptidase activity
K9S39_RS08040	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS08045	COG3568	Endonuclease Exonuclease Phosphatase
K9S39_RS08055	COG1113	amino acid transport
K9S39_RS08070	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9S39_RS08070	COG1024	Enoyl-CoA hydratase
K9S39_RS08075	COG0183	Belongs to the thiolase family
K9S39_RS08080	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS08085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K9S39_RS08090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K9S39_RS08105	COG3268	Saccharopine dehydrogenase
K9S39_RS08110	COG1515	deoxyribonuclease V activity
K9S39_RS08120	COG2814	Major facilitator Superfamily
K9S39_RS08125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K9S39_RS08135	COG1349	DNA-binding transcription factor activity
K9S39_RS08140	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS08180	COG0183	Belongs to the thiolase family
K9S39_RS08185	COG1309	transcriptional regulator
K9S39_RS08190	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS08195	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS08205	COG1846	Transcriptional regulator
K9S39_RS08225	COG3226	Transcriptional regulator
K9S39_RS08250	COG0745	RESPONSE REGULATOR receiver
K9S39_RS08255	COG2205	protein histidine kinase activity
K9S39_RS08295	COG0405	Gamma-glutamyltransferase
K9S39_RS08305	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS08345	COG3903	Transcriptional regulator
K9S39_RS08345	COG3629	intracellular signal transduction
K9S39_RS08360	COG0494	nUDIX hydrolase
K9S39_RS08375	COG2205	protein histidine kinase activity
K9S39_RS08460	COG1999	signal sequence binding
K9S39_RS08500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K9S39_RS08525	COG0019	diaminopimelate decarboxylase activity
K9S39_RS08540	COG4264	IucA IucC family
K9S39_RS08545	COG2814	Major facilitator Superfamily
K9S39_RS08550	COG4264	IucA IucC family
K9S39_RS08555	COG2423	ornithine cyclodeaminase activity
K9S39_RS08560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K9S39_RS08565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K9S39_RS08570	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K9S39_RS08575	COG1120	ATPase activity
K9S39_RS08580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K9S39_RS08615	COG2239	Acts as a magnesium transporter
K9S39_RS08625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K9S39_RS08640	COG0604	alcohol dehydrogenase
K9S39_RS08640	COG3321	synthase
K9S39_RS08660	COG1819	glycosyl
K9S39_RS08675	COG3540	Alkaline phosphatase
K9S39_RS08685	COG0798	PFAM Bile acid sodium symporter
K9S39_RS08695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K9S39_RS08705	COG1695	Transcriptional regulator
K9S39_RS08710	COG2259	Doxx family
K9S39_RS08755	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K9S39_RS08770	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K9S39_RS08835	COG0789	Transcriptional regulator
K9S39_RS08855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K9S39_RS08865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K9S39_RS08915	COG0477	Major facilitator Superfamily
K9S39_RS08920	COG0477	Major facilitator Superfamily
K9S39_RS08965	COG3903	Transcriptional regulator
K9S39_RS08965	COG3629	intracellular signal transduction
K9S39_RS08980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K9S39_RS09005	COG0688	phosphatidylethanolamine metabolic process
K9S39_RS09050	COG0156	8-amino-7-oxononanoate synthase activity
K9S39_RS09055	COG0300	oxidoreductase activity
K9S39_RS09090	COG3012	SEC-C Motif Domain Protein
K9S39_RS09130	COG2234	aminopeptidase activity
K9S39_RS09130	COG4935	Belongs to the peptidase S8 family
K9S39_RS09140	COG2814	Major facilitator Superfamily
K9S39_RS09145	COG1309	transcriptional regulator
K9S39_RS09210	COG0515	serine threonine protein kinase
K9S39_RS09220	COG0019	diaminopimelate decarboxylase activity
K9S39_RS09255	COG0174	glutamine synthetase
K9S39_RS09260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K9S39_RS09265	COG1120	ATPase activity
K9S39_RS09270	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K9S39_RS09275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K9S39_RS09285	COG4651	solute:proton antiporter activity
K9S39_RS09285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K9S39_RS09300	COG3835	regulator
K9S39_RS09415	COG0583	DNA-binding transcription factor activity
K9S39_RS09420	COG2409	Drug exporters of the RND superfamily
K9S39_RS09450	COG1105	Belongs to the carbohydrate kinase PfkB family
K9S39_RS09455	COG1940	carbohydrate kinase activity
K9S39_RS09460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K9S39_RS09465	COG0395	ABC-type sugar transport system, permease component
K9S39_RS09480	COG1349	DNA-binding transcription factor activity
K9S39_RS09505	COG1295	ribonuclease BN
K9S39_RS09595	COG2814	Major facilitator Superfamily
K9S39_RS09600	COG2814	Major facilitator Superfamily
K9S39_RS09615	COG0577	efflux transmembrane transporter activity
K9S39_RS09620	COG1136	(ABC) transporter
K9S39_RS09620	COG0577	efflux transmembrane transporter activity
K9S39_RS09625	COG2197	response regulator
K9S39_RS09630	COG4585	Histidine kinase
K9S39_RS09635	COG1695	Transcriptional regulator
K9S39_RS09670	COG3291	Pkd domain containing protein
K9S39_RS09695	COG1802	Transcriptional regulator
K9S39_RS09705	COG3938	Belongs to the proline racemase family
K9S39_RS09725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9S39_RS09730	COG0006	proline dipeptidase activity
K9S39_RS09740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K9S39_RS09755	COG4608	Belongs to the ABC transporter superfamily
K9S39_RS09765	COG0583	DNA-binding transcription factor activity
K9S39_RS09775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K9S39_RS09775	COG2146	nitrite reductase [NAD(P)H] activity
K9S39_RS09805	COG1953	Uracil, thiamine, allantoin
K9S39_RS09815	COG3118	belongs to the thioredoxin family
K9S39_RS09975	COG0583	DNA-binding transcription factor activity
K9S39_RS09990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K9S39_RS10005	COG0697	spore germination
K9S39_RS10040	COG2124	cytochrome p450
K9S39_RS10065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9S39_RS10065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9S39_RS10075	COG1022	Amp-dependent synthetase and ligase
K9S39_RS10095	COG2091	lysine biosynthetic process via aminoadipic acid
K9S39_RS10125	COG2801	Transposase and inactivated derivatives
K9S39_RS10285	COG1605	Chorismate mutase
K9S39_RS10285	COG0287	Prephenate dehydrogenase
K9S39_RS10295	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K9S39_RS10325	COG0583	DNA-binding transcription factor activity
K9S39_RS10335	COG0656	L-ascorbic acid biosynthetic process
K9S39_RS10345	COG4977	sequence-specific DNA binding
K9S39_RS10355	COG2814	Major facilitator Superfamily
K9S39_RS10370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K9S39_RS10415	COG4106	trans-aconitate 2-methyltransferase activity
K9S39_RS10425	COG1295	ribonuclease BN
K9S39_RS10430	COG2154	pterin-4-alpha-carbinolamine dehydratase
K9S39_RS10445	COG0531	amino acid
K9S39_RS10465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K9S39_RS10515	COG2124	cytochrome p450
K9S39_RS10535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9S39_RS10540	COG2362	D-Aminopeptidase
K9S39_RS10555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K9S39_RS10565	COG1136	(ABC) transporter
K9S39_RS10565	COG0577	efflux transmembrane transporter activity
K9S39_RS10575	COG1653	transport
K9S39_RS10580	COG0366	Alpha amylase catalytic
K9S39_RS10585	COG1653	transport
K9S39_RS10590	COG1175	transmembrane transport
K9S39_RS10595	COG0395	ABC-type sugar transport system, permease component
K9S39_RS10605	COG0647	UMP catabolic process
K9S39_RS10625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K9S39_RS10630	COG1366	Belongs to the anti-sigma-factor antagonist family
K9S39_RS10630	COG2208	phosphoserine phosphatase activity
K9S39_RS10630	COG2172	sigma factor antagonist activity
K9S39_RS10635	COG0477	Major facilitator Superfamily
K9S39_RS10670	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9S39_RS10685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K9S39_RS10685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K9S39_RS10690	COG2301	Belongs to the HpcH HpaI aldolase family
K9S39_RS10700	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS10705	COG0688	phosphatidylethanolamine metabolic process
K9S39_RS10715	COG1929	Belongs to the glycerate kinase type-1 family
K9S39_RS10735	COG2267	carboxylic ester hydrolase activity
K9S39_RS10750	COG0697	spore germination
K9S39_RS10775	COG1461	Dihydroxyacetone kinase
K9S39_RS10785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K9S39_RS10785	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K9S39_RS10785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K9S39_RS10800	COG0483	inositol monophosphate 1-phosphatase activity
K9S39_RS10815	COG0095	Lipoate-protein ligase
K9S39_RS10825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K9S39_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS10875	COG0300	oxidoreductase activity
K9S39_RS10925	COG0765	amino acid transport
K9S39_RS10930	COG0765	amino acid transport
K9S39_RS10935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K9S39_RS10940	COG1126	abc transporter atp-binding protein
K9S39_RS10965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K9S39_RS10980	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS11020	COG1132	(ABC) transporter
K9S39_RS11050	COG2124	cytochrome p450
K9S39_RS11185	COG0357	Ribosomal RNA small subunit methyltransferase G
K9S39_RS11245	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K9S39_RS11270	COG2072	flavoprotein involved in K transport
K9S39_RS11295	COG3387	PFAM Glycoside hydrolase 15-related
K9S39_RS11330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9S39_RS11345	COG1940	carbohydrate kinase activity
K9S39_RS11355	COG1172	Belongs to the binding-protein-dependent transport system permease family
K9S39_RS11370	COG2188	Transcriptional regulator
K9S39_RS11380	COG0800	Aldolase
K9S39_RS11405	COG4266	Belongs to the allantoicase family
K9S39_RS11410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K9S39_RS11415	COG1414	Transcriptional regulator
K9S39_RS11440	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K9S39_RS11455	COG2233	PERMEase
K9S39_RS11470	COG2351	hydroxyisourate hydrolase activity
K9S39_RS11490	COG3622	Belongs to the hyi family
K9S39_RS11495	COG2084	Dehydrogenase
K9S39_RS11500	COG0753	catalase activity
K9S39_RS11515	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS11520	COG0475	glutathione-regulated potassium exporter activity
K9S39_RS11525	COG0038	chloride channel
K9S39_RS11540	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS11545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K9S39_RS11565	COG2252	PERMEase
K9S39_RS11570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9S39_RS11585	COG3835	regulator
K9S39_RS11600	COG1802	Transcriptional regulator
K9S39_RS11650	COG2208	phosphoserine phosphatase activity
K9S39_RS11650	COG2770	Histidine kinase
K9S39_RS11675	COG0473	3-isopropylmalate dehydrogenase activity
K9S39_RS11675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K9S39_RS11685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K9S39_RS11690	COG0583	DNA-binding transcription factor activity
K9S39_RS11695	COG2814	Major facilitator Superfamily
K9S39_RS11705	COG1942	4-Oxalocrotonate Tautomerase
K9S39_RS11710	COG2814	Major facilitator Superfamily
K9S39_RS11715	COG0583	DNA-binding transcription factor activity
K9S39_RS11750	COG1115	amino acid carrier protein
K9S39_RS11755	COG0569	domain protein
K9S39_RS11760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K9S39_RS11775	COG2255	four-way junction helicase activity
K9S39_RS11795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K9S39_RS11800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9S39_RS11800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9S39_RS11810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K9S39_RS11810	COG2755	lipolytic protein G-D-S-L family
K9S39_RS11815	COG1215	transferase activity, transferring glycosyl groups
K9S39_RS11840	COG1376	ErfK ybiS ycfS ynhG family protein
K9S39_RS11845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K9S39_RS11855	COG3511	phospholipase C
K9S39_RS11865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K9S39_RS11880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9S39_RS11885	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K9S39_RS11890	COG2080	2 iron, 2 sulfur cluster binding
K9S39_RS11925	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS11965	COG0175	sulfate reduction
K9S39_RS11970	COG0529	Catalyzes the synthesis of activated sulfate
K9S39_RS11995	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
K9S39_RS12000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K9S39_RS12050	COG3251	PFAM MbtH domain protein
K9S39_RS12055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9S39_RS12065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9S39_RS12065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9S39_RS12070	COG3903	Transcriptional regulator
K9S39_RS12070	COG3629	intracellular signal transduction
K9S39_RS12095	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS12105	COG1834	amidinotransferase
K9S39_RS12125	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS12185	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS12210	COG0583	DNA-binding transcription factor activity
K9S39_RS12215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K9S39_RS12240	COG0693	protein deglycase activity
K9S39_RS12250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K9S39_RS12280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K9S39_RS12285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K9S39_RS12290	COG2197	response regulator
K9S39_RS12310	COG2409	Drug exporters of the RND superfamily
K9S39_RS12395	COG0477	Major facilitator Superfamily
K9S39_RS12430	COG1116	anion transmembrane transporter activity
K9S39_RS12450	COG1073	alpha beta
K9S39_RS12450	COG2226	methyltransferase
K9S39_RS12455	COG0789	Transcriptional regulator
K9S39_RS12475	COG1278	Cold shock
K9S39_RS12520	COG3253	May function as heme-dependent peroxidase
K9S39_RS12525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K9S39_RS12535	COG0183	Belongs to the thiolase family
K9S39_RS12545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K9S39_RS12560	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K9S39_RS12565	COG0183	Belongs to the thiolase family
K9S39_RS12570	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9S39_RS12570	COG1024	Enoyl-CoA hydratase
K9S39_RS12580	COG0531	amino acid
K9S39_RS12585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K9S39_RS12590	COG4214	carbohydrate transport
K9S39_RS12605	COG1940	carbohydrate kinase activity
K9S39_RS12610	COG0395	ABC-type sugar transport system, permease component
K9S39_RS12615	COG1175	transmembrane transport
K9S39_RS12620	COG1653	transport
K9S39_RS12630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K9S39_RS12645	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS12670	COG3480	Lon protease (S16) C-terminal proteolytic domain
K9S39_RS12680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K9S39_RS12745	COG1024	Enoyl-CoA hydratase
K9S39_RS12750	COG0531	amino acid
K9S39_RS12755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K9S39_RS12760	COG2235	arginine
K9S39_RS12765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K9S39_RS12795	COG1799	cell septum assembly
K9S39_RS12835	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS12845	COG0604	alcohol dehydrogenase
K9S39_RS12845	COG3321	synthase
K9S39_RS12870	COG2197	response regulator
K9S39_RS12890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K9S39_RS12895	COG0531	amino acid
K9S39_RS12900	COG0569	domain protein
K9S39_RS12935	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K9S39_RS12940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K9S39_RS12945	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K9S39_RS12960	COG0756	dUTP diphosphatase activity
K9S39_RS12985	COG2205	protein histidine kinase activity
K9S39_RS12990	COG0745	RESPONSE REGULATOR receiver
K9S39_RS13005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K9S39_RS13040	COG1435	thymidine kinase activity
K9S39_RS13060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K9S39_RS13065	COG1802	Transcriptional regulator
K9S39_RS13080	COG0612	Peptidase, M16
K9S39_RS13085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K9S39_RS13095	COG0372	Belongs to the citrate synthase family
K9S39_RS13115	COG3290	protein histidine kinase activity
K9S39_RS13120	COG4565	transcriptional regulatory protein
K9S39_RS13125	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS13145	COG0187	DNA topoisomerase II activity
K9S39_RS13215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K9S39_RS13220	COG2186	Transcriptional regulator
K9S39_RS13225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K9S39_RS13230	COG0494	nUDIX hydrolase
K9S39_RS13260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K9S39_RS13270	COG0588	phosphoglycerate mutase activity
K9S39_RS13295	COG0154	amidase activity
K9S39_RS13300	COG3226	Transcriptional regulator
K9S39_RS13320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K9S39_RS13325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K9S39_RS13330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K9S39_RS13365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K9S39_RS13375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K9S39_RS13380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K9S39_RS13390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K9S39_RS13405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K9S39_RS13415	COG1278	Cold shock
K9S39_RS13420	COG2205	protein histidine kinase activity
K9S39_RS13425	COG0745	RESPONSE REGULATOR receiver
K9S39_RS13430	COG1126	abc transporter atp-binding protein
K9S39_RS13435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K9S39_RS13440	COG0765	amino acid transport
K9S39_RS13445	COG0765	amino acid transport
K9S39_RS13450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9S39_RS13465	COG2137	regulation of response to DNA damage stimulus
K9S39_RS13480	COG0628	permease
K9S39_RS13495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9S39_RS13495	COG3321	synthase
K9S39_RS13535	COG1201	RNA secondary structure unwinding
K9S39_RS13540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K9S39_RS13550	COG0783	Belongs to the Dps family
K9S39_RS13555	COG1396	sequence-specific DNA binding
K9S39_RS13560	COG1058	Belongs to the CinA family
K9S39_RS13560	COG1546	Belongs to the CinA family
K9S39_RS13570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K9S39_RS13580	COG1674	ftsk spoiiie
K9S39_RS13590	COG2205	protein histidine kinase activity
K9S39_RS13590	COG3437	response regulator, receiver
K9S39_RS13590	COG3850	Histidine kinase
K9S39_RS13590	COG4999	Histidine kinase
K9S39_RS13630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K9S39_RS13635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K9S39_RS13640	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K9S39_RS13660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K9S39_RS13665	COG0612	Peptidase, M16
K9S39_RS13670	COG1185	polyribonucleotide nucleotidyltransferase activity
K9S39_RS13675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K9S39_RS13685	COG1674	ftsk spoiiie
K9S39_RS13735	COG3209	COG3209 Rhs family protein
K9S39_RS13765	COG1404	Belongs to the peptidase S8 family
K9S39_RS13815	COG0455	bacterial-type flagellum organization
K9S39_RS13830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K9S39_RS13835	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K9S39_RS13845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K9S39_RS13860	COG0779	Required for maturation of 30S ribosomal subunits
K9S39_RS13875	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
K9S39_RS13880	COG0442	prolyl-tRNA aminoacylation
K9S39_RS13895	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K9S39_RS13900	COG0750	zinc metalloprotease
K9S39_RS13905	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K9S39_RS13915	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS13945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9S39_RS13950	COG1177	transmembrane transport
K9S39_RS13955	COG1176	ABC-type spermidine putrescine transport system, permease component I
K9S39_RS13960	COG3842	ATPase activity
K9S39_RS13970	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS13980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K9S39_RS14000	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS14010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K9S39_RS14015	COG4181	ATPase activity
K9S39_RS14045	COG3842	ATPase activity
K9S39_RS14050	COG4208	sulfate ABC transporter
K9S39_RS14060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K9S39_RS14070	COG0233	cytoplasmic translational termination
K9S39_RS14075	COG0528	UMP kinase activity
K9S39_RS14080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K9S39_RS14085	COG0052	Belongs to the universal ribosomal protein uS2 family
K9S39_RS14100	COG1191	sigma factor activity
K9S39_RS14345	COG1278	Cold shock
K9S39_RS14370	COG0792	nuclease activity
K9S39_RS14390	COG0681	Belongs to the peptidase S26 family
K9S39_RS14395	COG0681	Belongs to the peptidase S26 family
K9S39_RS14400	COG0681	Belongs to the peptidase S26 family
K9S39_RS14405	COG0335	large ribosomal subunit rRNA binding
K9S39_RS14410	COG0336	Belongs to the RNA methyltransferase TrmD family
K9S39_RS14415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K9S39_RS14420	COG1837	Belongs to the UPF0109 family
K9S39_RS14425	COG0228	four-way junction DNA binding
K9S39_RS14445	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K9S39_RS14475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K9S39_RS14480	COG0477	Major facilitator Superfamily
K9S39_RS14495	COG1254	Belongs to the acylphosphatase family
K9S39_RS14500	COG2340	Cysteine-rich secretory protein family
K9S39_RS14505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K9S39_RS14510	COG0571	ribonuclease III activity
K9S39_RS14515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K9S39_RS14530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K9S39_RS14535	COG0742	ribosomal rna small subunit methyltransferase
K9S39_RS14540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K9S39_RS14545	COG1461	Dihydroxyacetone kinase
K9S39_RS14550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K9S39_RS14555	COG0351	phosphomethylpyrimidine kinase
K9S39_RS14575	COG1181	Belongs to the D-alanine--D-alanine ligase family
K9S39_RS14585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K9S39_RS14595	COG1920	GTP binding
K9S39_RS14605	COG0776	regulation of translation
K9S39_RS14615	COG0066	3-isopropylmalate dehydratase activity
K9S39_RS14620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K9S39_RS14625	COG1414	Transcriptional regulator
K9S39_RS14670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K9S39_RS14675	COG0179	Fumarylacetoacetate (FAA) hydrolase
K9S39_RS14690	COG2018	Roadblock/LC7 domain
K9S39_RS14710	COG2018	Roadblock/LC7 domain
K9S39_RS14725	COG2376	Dihydroxyacetone kinase
K9S39_RS14740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K9S39_RS14745	COG5492	domain, Protein
K9S39_RS14750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K9S39_RS14755	COG0477	Major facilitator Superfamily
K9S39_RS14760	COG1309	transcriptional regulator
K9S39_RS14765	COG2957	Belongs to the agmatine deiminase family
K9S39_RS14770	COG0804	urea catabolic process
K9S39_RS14775	COG0831	urea catabolic process
K9S39_RS14775	COG0832	Belongs to the urease beta subunit family
K9S39_RS14790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K9S39_RS14795	COG0473	3-isopropylmalate dehydrogenase activity
K9S39_RS14800	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS14805	COG0506	proline dehydrogenase activity
K9S39_RS14825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K9S39_RS14830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K9S39_RS14835	COG0440	acetolactate synthase activity
K9S39_RS14845	COG3300	MHYT domain
K9S39_RS14845	COG5001	Diguanylate cyclase
K9S39_RS14855	COG0667	Aldo Keto reductase
K9S39_RS14860	COG2133	pyrroloquinoline quinone binding
K9S39_RS14875	COG2409	Drug exporters of the RND superfamily
K9S39_RS14880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K9S39_RS14890	COG0154	amidase activity
K9S39_RS14895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K9S39_RS14905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K9S39_RS14915	COG0477	Major facilitator Superfamily
K9S39_RS14925	COG4221	oxidoreductase activity
K9S39_RS14945	COG0482	sulfurtransferase activity
K9S39_RS14960	COG3903	Transcriptional regulator
K9S39_RS14960	COG3629	intracellular signal transduction
K9S39_RS14985	COG2860	membrane
K9S39_RS15005	COG4608	Belongs to the ABC transporter superfamily
K9S39_RS15020	COG0747	negative chemotaxis
K9S39_RS15040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K9S39_RS15045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K9S39_RS15050	COG0509	glycine decarboxylation via glycine cleavage system
K9S39_RS15055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K9S39_RS15060	COG1760	l-serine dehydratase
K9S39_RS15095	COG0671	phosphoesterase, PA-phosphatase related
K9S39_RS15110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K9S39_RS15120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K9S39_RS15125	COG0785	Cytochrome C biogenesis protein
K9S39_RS15130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K9S39_RS15130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K9S39_RS15150	COG1376	ErfK ybiS ycfS ynhG family protein
K9S39_RS15165	COG1132	(ABC) transporter
K9S39_RS15170	COG1132	(ABC) transporter
K9S39_RS15185	COG0058	SHG alpha-glucan phosphorylase activity
K9S39_RS15190	COG0366	Alpha amylase catalytic
K9S39_RS15195	COG0366	Alpha amylase catalytic
K9S39_RS15200	COG3281	Trehalose synthase
K9S39_RS15205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K9S39_RS15215	COG1301	dicarboxylic acid transport
K9S39_RS15230	COG1175	transmembrane transport
K9S39_RS15235	COG0395	ABC-type sugar transport system, permease component
K9S39_RS15245	COG1136	(ABC) transporter
K9S39_RS15250	COG0577	efflux transmembrane transporter activity
K9S39_RS15255	COG0205	6-phosphofructokinase activity
K9S39_RS15260	COG0280	phosphate acetyltransferase
K9S39_RS15260	COG0857	belongs to the CobB CobQ family
K9S39_RS15265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K9S39_RS15300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9S39_RS15305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K9S39_RS15330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K9S39_RS15330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K9S39_RS15375	COG0745	RESPONSE REGULATOR receiver
K9S39_RS15390	COG0183	Belongs to the thiolase family
K9S39_RS15445	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
K9S39_RS15460	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9S39_RS15495	COG2197	response regulator
K9S39_RS15505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K9S39_RS15510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K9S39_RS15515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K9S39_RS15520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K9S39_RS15525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K9S39_RS15530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K9S39_RS15535	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K9S39_RS15555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K9S39_RS15560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K9S39_RS15570	COG2890	protein-(glutamine-N5) methyltransferase activity
K9S39_RS15575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K9S39_RS15580	COG0254	rRNA binding
K9S39_RS15595	COG0083	homoserine kinase activity
K9S39_RS15600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K9S39_RS15605	COG0460	homoserine dehydrogenase
K9S39_RS15610	COG0019	diaminopimelate decarboxylase activity
K9S39_RS15615	COG0018	arginyl-trna synthetase
K9S39_RS15720	COG2186	Transcriptional regulator
K9S39_RS15780	COG2124	cytochrome p450
K9S39_RS15810	COG0768	penicillin binding
K9S39_RS15850	COG0791	NLP P60 protein
K9S39_RS15875	COG5002	protein histidine kinase activity
K9S39_RS15895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K9S39_RS15900	COG1357	PFAM Pentapeptide repeats (8 copies)
K9S39_RS15915	COG0745	RESPONSE REGULATOR receiver
K9S39_RS15920	COG2205	protein histidine kinase activity
K9S39_RS15925	COG0508	dehydrogenase complex catalyzes the overall conversion of
K9S39_RS15925	COG0567	Dehydrogenase, E1 component
K9S39_RS15950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K9S39_RS15970	COG0604	alcohol dehydrogenase
K9S39_RS15975	COG0281	malic enzyme
K9S39_RS15990	COG1126	abc transporter atp-binding protein
K9S39_RS16030	COG0598	Magnesium transport protein CorA
K9S39_RS16035	COG0477	Major facilitator Superfamily
K9S39_RS16055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9S39_RS16065	COG2066	Belongs to the glutaminase family
K9S39_RS16085	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K9S39_RS16120	COG1597	lipid kinase activity
K9S39_RS16135	COG1309	transcriptional regulator
K9S39_RS16140	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS16145	COG0363	glucosamine-6-phosphate deaminase activity
K9S39_RS16150	COG1472	Belongs to the glycosyl hydrolase 3 family
K9S39_RS16155	COG0395	ABC-type sugar transport system, permease component
K9S39_RS16160	COG1175	transmembrane transport
K9S39_RS16165	COG2182	Extracellular solute-binding protein
K9S39_RS16170	COG2188	Transcriptional regulator
K9S39_RS16195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K9S39_RS16200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K9S39_RS16205	COG0242	peptide deformylase activity
K9S39_RS16225	COG5662	AntiSigma factor
K9S39_RS16230	COG1595	DNA-templated transcription, initiation
K9S39_RS16235	COG1396	sequence-specific DNA binding
K9S39_RS16235	COG3800	Transcriptional regulator
K9S39_RS16245	COG2135	peptidase activity
K9S39_RS16255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K9S39_RS16260	COG1162	GTPase activity
K9S39_RS16265	COG2076	Multidrug Resistance protein
K9S39_RS16275	COG0483	inositol monophosphate 1-phosphatase activity
K9S39_RS16285	COG0753	catalase activity
K9S39_RS16310	COG1615	UPF0182 protein
K9S39_RS16320	COG3480	Lon protease (S16) C-terminal proteolytic domain
K9S39_RS16375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K9S39_RS16415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9S39_RS16420	COG0210	DNA helicase
K9S39_RS16470	COG2267	carboxylic ester hydrolase activity
K9S39_RS16510	COG1432	Conserved Protein
K9S39_RS16520	COG2095	MarC family integral membrane protein
K9S39_RS16540	COG0598	Magnesium transport protein CorA
K9S39_RS16555	COG2239	Acts as a magnesium transporter
K9S39_RS16575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K9S39_RS16580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K9S39_RS16590	COG1595	DNA-templated transcription, initiation
K9S39_RS16605	COG1024	Enoyl-CoA hydratase
K9S39_RS16610	COG0519	Catalyzes the synthesis of GMP from XMP
K9S39_RS16620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K9S39_RS16625	COG1611	Belongs to the LOG family
K9S39_RS16630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9S39_RS16670	COG2197	response regulator
K9S39_RS16675	COG4585	Histidine kinase
K9S39_RS16685	COG1131	(ABC) transporter
K9S39_RS16700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K9S39_RS16715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K9S39_RS16720	COG4166	transmembrane transport
K9S39_RS16730	COG0444	Belongs to the ABC transporter superfamily
K9S39_RS16735	COG4608	Belongs to the ABC transporter superfamily
K9S39_RS16740	COG4608	Belongs to the ABC transporter superfamily
K9S39_RS16750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K9S39_RS16755	COG0601	transmembrane transport
K9S39_RS16780	COG1217	gtp-binding protein TYPA
K9S39_RS16800	COG1053	succinate dehydrogenase
K9S39_RS16810	COG0402	S-adenosylhomocysteine deaminase activity
K9S39_RS16835	COG0531	amino acid
K9S39_RS16855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K9S39_RS16860	COG2423	ornithine cyclodeaminase activity
K9S39_RS16870	COG0626	cystathionine gamma-synthase activity
K9S39_RS16875	COG3135	benzoate transporter
K9S39_RS16890	COG1414	Transcriptional regulator
K9S39_RS16895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K9S39_RS16900	COG0012	GTP binding
K9S39_RS16910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K9S39_RS16920	COG1570	exodeoxyribonuclease VII activity
K9S39_RS16925	COG1722	exodeoxyribonuclease VII activity
K9S39_RS16930	COG0778	Nitroreductase
K9S39_RS16955	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K9S39_RS16955	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K9S39_RS16995	COG0114	fumarate hydratase activity
K9S39_RS17020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K9S39_RS17045	COG1136	(ABC) transporter
K9S39_RS17070	COG0450	alkyl hydroperoxide reductase
K9S39_RS17075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K9S39_RS17090	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K9S39_RS17095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K9S39_RS17100	COG0667	Aldo Keto reductase
K9S39_RS17170	COG2894	cell division
K9S39_RS17200	COG2610	gluconate transmembrane transporter activity
K9S39_RS17205	COG0251	oxidation-reduction process
K9S39_RS17210	COG1414	Transcriptional regulator
K9S39_RS17225	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K9S39_RS17260	COG1331	Highly conserved protein containing a thioredoxin domain
K9S39_RS17275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K9S39_RS17285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K9S39_RS17315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K9S39_RS17320	COG2255	four-way junction helicase activity
K9S39_RS17335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K9S39_RS17360	COG2986	histidine ammonia-lyase
K9S39_RS17370	COG1024	Enoyl-CoA hydratase
K9S39_RS17375	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
K9S39_RS17385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K9S39_RS17395	COG0768	penicillin binding
K9S39_RS17400	COG0424	maF-like protein
K9S39_RS17410	COG0693	protein deglycase activity
K9S39_RS17425	COG4770	biotin carboxylase activity
K9S39_RS17465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K9S39_RS17495	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K9S39_RS17500	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS17505	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS17525	COG1595	DNA-templated transcription, initiation
K9S39_RS17530	COG0745	RESPONSE REGULATOR receiver
K9S39_RS17535	COG2205	protein histidine kinase activity
K9S39_RS17560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K9S39_RS17570	COG0583	DNA-binding transcription factor activity
K9S39_RS17575	COG2814	Major facilitator Superfamily
K9S39_RS17590	COG1079	Belongs to the binding-protein-dependent transport system permease family
K9S39_RS17595	COG4603	Belongs to the binding-protein-dependent transport system permease family
K9S39_RS17600	COG3845	ABC transporter
K9S39_RS17605	COG1744	ABC transporter substrate-binding protein PnrA-like
K9S39_RS17610	COG1473	amidohydrolase
K9S39_RS17610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K9S39_RS17620	COG2089	acid synthase
K9S39_RS17625	COG1083	cytidylyl-transferase
K9S39_RS17635	COG1216	Glycosyl transferase, family 2
K9S39_RS17645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K9S39_RS17680	COG3265	gluconokinase activity
K9S39_RS17690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K9S39_RS17690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K9S39_RS17705	COG1595	DNA-templated transcription, initiation
K9S39_RS17720	COG2009	succinate dehydrogenase
K9S39_RS17730	COG1053	succinate dehydrogenase
K9S39_RS17735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K9S39_RS17775	COG1686	Belongs to the peptidase S11 family
K9S39_RS17780	COG1295	ribonuclease BN
K9S39_RS17790	COG0180	Tryptophanyl-tRNA synthetase
K9S39_RS17795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K9S39_RS17800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K9S39_RS17815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9S39_RS17820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9S39_RS17825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K9S39_RS17850	COG0667	Aldo Keto reductase
K9S39_RS17860	COG2076	Multidrug Resistance protein
K9S39_RS17870	COG4176	ABC-type proline glycine betaine transport system permease component
K9S39_RS17880	COG4175	Glycine betaine
K9S39_RS17880	COG0517	IMP dehydrogenase activity
K9S39_RS17890	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS17940	COG0039	L-malate dehydrogenase activity
K9S39_RS17970	COG0538	isocitrate dehydrogenase activity
K9S39_RS17980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K9S39_RS18000	COG0138	bifunctional purine biosynthesis protein purh
K9S39_RS18035	COG0045	succinate-CoA ligase (ADP-forming) activity
K9S39_RS18055	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K9S39_RS18060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K9S39_RS18065	COG0714	Associated with various cellular activities
K9S39_RS18080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K9S39_RS18110	COG0791	NLP P60 protein
K9S39_RS18120	COG2197	response regulator
K9S39_RS18130	COG0515	serine threonine protein kinase
K9S39_RS18130	COG2815	serine threonine protein kinase
K9S39_RS18165	COG2084	Dehydrogenase
K9S39_RS18170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K9S39_RS18170	COG0519	Catalyzes the synthesis of GMP from XMP
K9S39_RS18190	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS18195	COG0515	serine threonine protein kinase
K9S39_RS18215	COG4585	Histidine kinase
K9S39_RS18265	COG1131	(ABC) transporter
K9S39_RS18285	COG4821	SIS domain
K9S39_RS18295	COG0259	pyridoxamine-phosphate oxidase activity
K9S39_RS18325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K9S39_RS18350	COG5006	permease, DMT superfamily
K9S39_RS18400	COG0277	FAD linked oxidase domain protein
K9S39_RS18400	COG0247	lactate metabolic process
K9S39_RS18415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K9S39_RS18440	COG0667	Aldo Keto reductase
K9S39_RS18465	COG2252	PERMEase
K9S39_RS18490	COG2814	Major facilitator Superfamily
K9S39_RS18500	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K9S39_RS18505	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K9S39_RS18555	COG1061	Type III restriction enzyme res subunit
K9S39_RS18570	COG3973	AAA domain
K9S39_RS18575	COG3142	Participates in the control of copper homeostasis
K9S39_RS18615	COG1737	Transcriptional regulator
K9S39_RS18620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K9S39_RS18625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K9S39_RS18625	COG1263	PTS System
K9S39_RS18650	COG1278	Cold shock
K9S39_RS18665	COG0463	Glycosyl transferase, family 2
K9S39_RS18695	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K9S39_RS18700	COG1105	Belongs to the carbohydrate kinase PfkB family
K9S39_RS18720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K9S39_RS18990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K9S39_RS19125	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
K9S39_RS19175	COG0277	FAD linked oxidase domain protein
K9S39_RS19175	COG0247	lactate metabolic process
K9S39_RS19180	COG0179	Fumarylacetoacetate (FAA) hydrolase
K9S39_RS19205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K9S39_RS19235	COG1674	ftsk spoiiie
K9S39_RS19260	COG4257	antibiotic catabolic process
K9S39_RS19270	COG4974	Belongs to the 'phage' integrase family
K9S39_RS19275	COG4974	Belongs to the 'phage' integrase family
K9S39_RS19460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K9S39_RS19515	COG1136	(ABC) transporter
K9S39_RS19585	COG1475	DNA binding
K9S39_RS19595	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS19635	COG3842	ATPase activity
K9S39_RS19645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K9S39_RS19655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K9S39_RS19660	COG0215	cysteine-tRNA ligase activity
K9S39_RS19670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K9S39_RS19675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K9S39_RS19680	COG1329	Transcriptional regulator
K9S39_RS19695	COG5002	protein histidine kinase activity
K9S39_RS19710	COG0588	phosphoglycerate mutase activity
K9S39_RS19730	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS19745	COG0667	Aldo Keto reductase
K9S39_RS19775	COG3800	Transcriptional regulator
K9S39_RS19775	COG1396	sequence-specific DNA binding
K9S39_RS19795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K9S39_RS19800	COG0456	acetyltransferase
K9S39_RS19805	COG0737	Belongs to the 5'-nucleotidase family
K9S39_RS19815	COG2205	protein histidine kinase activity
K9S39_RS19830	COG1609	Transcriptional regulator
K9S39_RS19835	COG0745	RESPONSE REGULATOR receiver
K9S39_RS19865	COG2897	thiosulfate sulfurtransferase activity
K9S39_RS19885	COG3485	protocatechuate 3,4-dioxygenase
K9S39_RS19890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K9S39_RS19895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K9S39_RS19910	COG0354	folic acid binding
K9S39_RS19915	COG1490	D-aminoacyl-tRNA deacylase activity
K9S39_RS19935	COG0431	NADPH-dependent FMN reductase
K9S39_RS19960	COG0667	Aldo Keto reductase
K9S39_RS19975	COG2890	protein-(glutamine-N5) methyltransferase activity
K9S39_RS20025	COG0306	phosphate transporter
K9S39_RS20035	COG1937	Protein conserved in bacteria
K9S39_RS20055	COG0277	FAD linked oxidase domain protein
K9S39_RS20060	COG0671	phosphoesterase, PA-phosphatase related
K9S39_RS20065	COG0739	heme binding
K9S39_RS20065	COG0741	lytic transglycosylase activity
K9S39_RS20065	COG1196	nuclear chromosome segregation
K9S39_RS20145	COG0180	Tryptophanyl-tRNA synthetase
K9S39_RS20150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K9S39_RS20180	COG4991	sh3 domain protein
K9S39_RS20185	COG0515	serine threonine protein kinase
K9S39_RS20185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9S39_RS20190	COG0129	dihydroxy-acid dehydratase activity
K9S39_RS20200	COG1082	Xylose isomerase domain protein TIM barrel
K9S39_RS20205	COG0248	Ppx GppA phosphatase
K9S39_RS20225	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K9S39_RS20245	COG1194	a g-specific adenine glycosylase
K9S39_RS20250	COG1595	DNA-templated transcription, initiation
K9S39_RS20260	COG0745	RESPONSE REGULATOR receiver
K9S39_RS20265	COG2205	protein histidine kinase activity
K9S39_RS20300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K9S39_RS20320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K9S39_RS20330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K9S39_RS20335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K9S39_RS20360	COG0640	Transcriptional regulator
K9S39_RS20365	COG2197	response regulator
K9S39_RS20380	COG0649	NAD binding
K9S39_RS20390	COG1732	Glycine betaine
K9S39_RS20395	COG1174	glycine betaine transport
K9S39_RS20400	COG1174	glycine betaine transport
K9S39_RS20405	COG0517	IMP dehydrogenase activity
K9S39_RS20405	COG1125	glycine betaine transport
K9S39_RS20415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K9S39_RS20420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K9S39_RS20440	COG0302	gtp cyclohydrolase
K9S39_RS20455	COG0037	tRNA processing
K9S39_RS20465	COG2027	D-alanyl-D-alanine carboxypeptidase
K9S39_RS20470	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K9S39_RS20485	COG0393	Putative heavy-metal-binding
K9S39_RS20490	COG0789	Transcriptional regulator
K9S39_RS20500	COG0655	NAD(P)H dehydrogenase (quinone) activity
K9S39_RS20505	COG0076	glutamate decarboxylase activity
K9S39_RS20515	COG2318	DinB family
K9S39_RS20520	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS20550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K9S39_RS20560	COG0254	rRNA binding
K9S39_RS20565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K9S39_RS20570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K9S39_RS20575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K9S39_RS20580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K9S39_RS20585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K9S39_RS20585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K9S39_RS20615	COG1349	DNA-binding transcription factor activity
K9S39_RS20625	COG3594	Acyltransferase
K9S39_RS20630	COG0584	glycerophosphoryl diester phosphodiesterase
K9S39_RS20680	COG3903	Transcriptional regulator
K9S39_RS20680	COG3629	intracellular signal transduction
K9S39_RS20705	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS20710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K9S39_RS20715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K9S39_RS20725	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS20735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9S39_RS20745	COG0583	DNA-binding transcription factor activity
K9S39_RS20785	COG3251	PFAM MbtH domain protein
K9S39_RS20815	COG1136	(ABC) transporter
K9S39_RS20820	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS20835	COG2197	response regulator
K9S39_RS20850	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS20890	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS20915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K9S39_RS20920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K9S39_RS20925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K9S39_RS20925	COG1754	DNA topoisomerase type I activity
K9S39_RS20950	COG2890	protein-(glutamine-N5) methyltransferase activity
K9S39_RS20960	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K9S39_RS20970	COG2172	sigma factor antagonist activity
K9S39_RS20975	COG1366	Belongs to the anti-sigma-factor antagonist family
K9S39_RS20980	COG1111	helicase
K9S39_RS20980	COG1205	dead DEAH box helicase
K9S39_RS21075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K9S39_RS21080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K9S39_RS21090	COG2267	carboxylic ester hydrolase activity
K9S39_RS21120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9S39_RS21145	COG0003	Pfam Anion-transporting ATPase
K9S39_RS21160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K9S39_RS21165	COG1610	YqeY-like protein
K9S39_RS21170	COG1408	metallophosphoesterase
K9S39_RS21190	COG0270	DNA (cytosine-5-)-methyltransferase activity
K9S39_RS21270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K9S39_RS21285	COG0330	HflC and HflK could
K9S39_RS21290	COG1030	water channel activity
K9S39_RS21330	COG1309	transcriptional regulator
K9S39_RS21335	COG2319	Wd-40 repeat
K9S39_RS21335	COG4249	Peptidase C14 caspase catalytic subunit p20
K9S39_RS21365	COG1316	TRANSCRIPTIONal
K9S39_RS21370	COG1215	transferase activity, transferring glycosyl groups
K9S39_RS21405	COG1595	DNA-templated transcription, initiation
K9S39_RS21425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K9S39_RS21430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K9S39_RS21460	COG0640	Transcriptional regulator
K9S39_RS21465	COG2814	Major facilitator Superfamily
K9S39_RS21510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K9S39_RS21515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K9S39_RS21525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K9S39_RS21535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K9S39_RS21555	COG0736	holo-[acyl-carrier-protein] synthase activity
K9S39_RS21570	COG0659	secondary active sulfate transmembrane transporter activity
K9S39_RS21615	COG0515	serine threonine protein kinase
K9S39_RS21615	COG2815	serine threonine protein kinase
K9S39_RS21620	COG2226	methyltransferase
K9S39_RS21625	COG1278	Cold shock
K9S39_RS21635	COG1132	(ABC) transporter
K9S39_RS21660	COG2957	Belongs to the agmatine deiminase family
K9S39_RS21690	COG1834	amidinotransferase
K9S39_RS21695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K9S39_RS21725	COG0523	cobalamin synthesis protein
K9S39_RS21745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K9S39_RS21760	COG0590	tRNA wobble adenosine to inosine editing
K9S39_RS21785	COG1191	sigma factor activity
K9S39_RS21790	COG1191	sigma factor activity
K9S39_RS21810	COG0477	Major facilitator Superfamily
K9S39_RS21815	COG2353	YceI-like domain
K9S39_RS21825	COG0477	Major facilitator Superfamily
K9S39_RS21835	COG0745	RESPONSE REGULATOR receiver
K9S39_RS21855	COG2249	NAD(P)H dehydrogenase (quinone) activity
K9S39_RS21880	COG5000	phosphorelay sensor kinase activity
K9S39_RS21885	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS21910	COG1595	DNA-templated transcription, initiation
K9S39_RS21985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K9S39_RS22000	COG0653	protein targeting
K9S39_RS22020	COG0006	proline dipeptidase activity
K9S39_RS22050	COG2372	response to copper ion
K9S39_RS22055	COG2837	iron assimilation
K9S39_RS22060	COG0077	Prephenate dehydratase
K9S39_RS22065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K9S39_RS22070	COG0561	phosphatase activity
K9S39_RS22080	COG0583	DNA-binding transcription factor activity
K9S39_RS22100	COG2807	transmembrane transport
K9S39_RS22145	COG0789	Transcriptional regulator
K9S39_RS22160	COG0501	Belongs to the peptidase M48B family
K9S39_RS22175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K9S39_RS22200	COG0561	phosphatase activity
K9S39_RS22205	COG0739	heme binding
K9S39_RS22215	COG4988	ABC transporter
K9S39_RS22220	COG1294	oxidase, subunit
K9S39_RS22225	COG1271	oxidase subunit
K9S39_RS22235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K9S39_RS22240	COG1609	Transcriptional regulator
K9S39_RS22245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K9S39_RS22260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K9S39_RS22285	COG0662	Cupin 2, conserved barrel domain protein
K9S39_RS22290	COG1950	PFAM Membrane protein of
K9S39_RS22300	COG0626	cystathionine gamma-synthase activity
K9S39_RS22340	COG2814	Major facilitator Superfamily
K9S39_RS22385	COG0242	peptide deformylase activity
K9S39_RS22395	COG0534	Mate efflux family protein
K9S39_RS22405	COG0359	binds to the 23S rRNA
K9S39_RS22410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K9S39_RS22415	COG0629	single-stranded DNA binding
K9S39_RS22420	COG0360	Binds together with S18 to 16S ribosomal RNA
K9S39_RS22445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K9S39_RS22455	COG1260	myo-inositol-1-phosphate synthase
K9S39_RS22470	COG0617	tRNA 3'-terminal CCA addition
K9S39_RS22485	COG2815	serine threonine protein kinase
K9S39_RS22485	COG0515	serine threonine protein kinase
K9S39_RS22490	COG1595	DNA-templated transcription, initiation
K9S39_RS22500	COG0492	ferredoxin-NADP+ reductase activity
K9S39_RS22505	COG3118	belongs to the thioredoxin family
K9S39_RS22520	COG1192	Involved in chromosome partitioning
K9S39_RS22525	COG0357	Ribosomal RNA small subunit methyltransferase G
K9S39_RS22535	COG0706	membrane insertase activity
K9S39_RS22540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K9S39_RS22550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K9S39_RS22560	COG0592	DNA-directed DNA polymerase activity
K9S39_RS22565	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K9S39_RS22570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K9S39_RS22575	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
K9S39_RS22580	COG0187	DNA topoisomerase II activity
K9S39_RS22585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K9S39_RS22610	COG0515	serine threonine protein kinase
K9S39_RS22650	COG0705	Rhomboid family
K9S39_RS22650	COG0457	Tetratricopeptide repeat
K9S39_RS22665	COG3764	Sortase (surface protein transpeptidase)
K9S39_RS22680	COG3764	Sortase (surface protein transpeptidase)
K9S39_RS22685	COG3764	Sortase (surface protein transpeptidase)
K9S39_RS22690	COG0515	serine threonine protein kinase
K9S39_RS22695	COG0768	penicillin binding
K9S39_RS22710	COG1716	ATPase activity
K9S39_RS22715	COG1716	ATPase activity
K9S39_RS22745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K9S39_RS22750	COG2151	metal-sulfur cluster biosynthetic enzyme
K9S39_RS22755	COG3396	Phenylacetate-CoA oxygenase
K9S39_RS22760	COG3460	Phenylacetate-CoA oxygenase
K9S39_RS22765	COG3396	Phenylacetate-CoA oxygenase
K9S39_RS22790	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9S39_RS22795	COG1309	transcriptional regulator
K9S39_RS22800	COG1522	sequence-specific DNA binding
K9S39_RS22815	COG0508	dehydrogenase complex catalyzes the overall conversion of
K9S39_RS22825	COG0303	'Molybdopterin
K9S39_RS22865	COG0515	serine threonine protein kinase
K9S39_RS22870	COG0515	serine threonine protein kinase
K9S39_RS22895	COG0022	dehydrogenase e1 component
K9S39_RS22900	COG0508	dehydrogenase complex catalyzes the overall conversion of
K9S39_RS22990	COG3903	Transcriptional regulator
K9S39_RS22990	COG3629	intracellular signal transduction
K9S39_RS22995	COG1362	aminopeptidase activity
K9S39_RS23000	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS23025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K9S39_RS23030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9S39_RS23055	COG0726	polysaccharide deacetylase
K9S39_RS23060	COG1174	glycine betaine transport
K9S39_RS23065	COG1174	glycine betaine transport
K9S39_RS23075	COG0745	RESPONSE REGULATOR receiver
K9S39_RS23110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K9S39_RS23125	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K9S39_RS23140	COG0667	Aldo Keto reductase
K9S39_RS23205	COG1316	TRANSCRIPTIONal
K9S39_RS23265	COG0517	IMP dehydrogenase activity
K9S39_RS23265	COG0516	GMP reductase activity
K9S39_RS23310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9S39_RS23345	COG2205	protein histidine kinase activity
K9S39_RS23355	COG1250	3-hydroxyacyl-CoA dehydrogenase
K9S39_RS23355	COG1024	Enoyl-CoA hydratase
K9S39_RS23360	COG1733	regulation of RNA biosynthetic process
K9S39_RS23365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K9S39_RS23385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K9S39_RS23395	COG1132	(ABC) transporter
K9S39_RS23425	COG2197	response regulator
K9S39_RS23565	COG0215	cysteine-tRNA ligase activity
K9S39_RS23595	COG4555	ABC transporter
K9S39_RS23615	COG1131	(ABC) transporter
K9S39_RS23675	COG0717	Belongs to the dCTP deaminase family
K9S39_RS23700	COG2181	nitrate reductase activity
K9S39_RS23700	COG0247	lactate metabolic process
K9S39_RS23705	COG0443	Heat shock 70 kDa protein
K9S39_RS23710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K9S39_RS23715	COG0484	heat shock protein binding
K9S39_RS23720	COG0789	Transcriptional regulator
K9S39_RS23740	COG0542	response to heat
K9S39_RS23760	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K9S39_RS23775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K9S39_RS23780	COG0191	fructose-bisphosphate aldolase activity
K9S39_RS23790	COG3483	tryptophan 2,3-dioxygenase activity
K9S39_RS23805	COG4585	Histidine kinase
K9S39_RS23810	COG2197	response regulator
K9S39_RS23820	COG3559	Exporter of polyketide antibiotics
K9S39_RS23825	COG1131	(ABC) transporter
K9S39_RS23840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K9S39_RS23885	COG0745	RESPONSE REGULATOR receiver
K9S39_RS23895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K9S39_RS23900	COG1802	Transcriptional regulator
K9S39_RS23915	COG0151	Belongs to the GarS family
K9S39_RS23930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K9S39_RS23940	COG2197	response regulator
K9S39_RS23955	COG1131	(ABC) transporter
K9S39_RS23975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K9S39_RS23980	COG0047	phosphoribosylformylglycinamidine synthase activity
K9S39_RS23985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K9S39_RS24000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K9S39_RS24035	COG1643	Atp-dependent helicase
K9S39_RS24090	COG0582	viral genome integration into host DNA
K9S39_RS24170	COG0667	Aldo Keto reductase
K9S39_RS24185	COG0667	Aldo Keto reductase
K9S39_RS24205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K9S39_RS24210	COG0579	oxidoreductase
K9S39_RS24225	COG0366	Alpha amylase catalytic
K9S39_RS24225	COG1470	cell adhesion involved in biofilm formation
K9S39_RS24235	COG1252	NADH dehydrogenase
K9S39_RS24250	COG1846	Transcriptional regulator
K9S39_RS24270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K9S39_RS24280	COG0123	including yeast histone deacetylase and acetoin utilization protein
K9S39_RS24330	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K9S39_RS24335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K9S39_RS24340	COG0181	hydroxymethylbilane synthase activity
K9S39_RS24345	COG1648	precorrin-2 dehydrogenase activity
K9S39_RS24345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K9S39_RS24350	COG0113	porphobilinogen synthase activity
K9S39_RS24375	COG0018	arginyl-trna synthetase
K9S39_RS24380	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K9S39_RS24410	COG1690	Belongs to the RtcB family
K9S39_RS24420	COG1742	UPF0060 membrane protein
K9S39_RS24430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9S39_RS24460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K9S39_RS24465	COG0406	alpha-ribazole phosphatase activity
K9S39_RS24480	COG1333	cytochrome c biogenesis protein
K9S39_RS24485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K9S39_RS24495	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K9S39_RS24510	COG0163	prenyltransferase activity
K9S39_RS24525	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K9S39_RS24535	COG1301	dicarboxylic acid transport
K9S39_RS24545	COG1309	transcriptional regulator
K9S39_RS24560	COG1278	Cold shock
K9S39_RS24565	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K9S39_RS24570	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K9S39_RS24580	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K9S39_RS24590	COG2226	methyltransferase
K9S39_RS24620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9S39_RS24625	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9S39_RS24630	COG0649	NAD binding
K9S39_RS24640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K9S39_RS24645	COG1034	ATP synthesis coupled electron transport
K9S39_RS24650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K9S39_RS24655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9S39_RS24660	COG0839	Belongs to the complex I subunit 6 family
K9S39_RS24665	COG0713	ATP synthesis coupled electron transport
K9S39_RS24670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K9S39_RS24680	COG1007	ATP synthesis coupled electron transport
K9S39_RS24700	COG0142	geranyltranstransferase activity
K9S39_RS24725	COG1013	pyruvate-flavodoxin oxidoreductase activity
K9S39_RS24730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K9S39_RS24730	COG0674	pyruvate-flavodoxin oxidoreductase activity
K9S39_RS24740	COG4585	Histidine kinase
K9S39_RS24745	COG4585	Histidine kinase
K9S39_RS24760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9S39_RS24765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9S39_RS24770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9S39_RS24775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K9S39_RS24780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K9S39_RS24785	COG0839	Belongs to the complex I subunit 6 family
K9S39_RS24790	COG0713	ATP synthesis coupled electron transport
K9S39_RS24795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K9S39_RS24805	COG1007	ATP synthesis coupled electron transport
K9S39_RS24810	COG0501	Belongs to the peptidase M48B family
K9S39_RS24815	COG3304	Inner membrane component domain
K9S39_RS24825	COG1666	GTP binding
K9S39_RS24835	COG0702	epimerase
K9S39_RS24855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K9S39_RS24860	COG2030	dehydratase
K9S39_RS24870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K9S39_RS24875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K9S39_RS24880	COG0436	Aminotransferase
K9S39_RS24895	COG0250	Participates in transcription elongation, termination and antitermination
K9S39_RS24900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K9S39_RS24905	COG0081	regulation of translation
K9S39_RS24915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K9S39_RS24920	COG0222	ribosome binding
K9S39_RS24925	COG0085	RNA polymerase activity
K9S39_RS24930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K9S39_RS24940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K9S39_RS24945	COG0049	tRNA binding
K9S39_RS24950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K9S39_RS24955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K9S39_RS24960	COG0051	transcription antitermination factor activity, RNA binding
K9S39_RS24965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K9S39_RS24970	COG0088	Forms part of the polypeptide exit tunnel
K9S39_RS24975	COG0089	rRNA binding
K9S39_RS24980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K9S39_RS24985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K9S39_RS24990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K9S39_RS24995	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K9S39_RS25000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K9S39_RS25005	COG0255	Belongs to the universal ribosomal protein uL29 family
K9S39_RS25010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K9S39_RS25015	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K9S39_RS25020	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K9S39_RS25025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K9S39_RS25030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K9S39_RS25035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K9S39_RS25040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K9S39_RS25045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K9S39_RS25050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K9S39_RS25055	COG1841	ribosomal large subunit assembly
K9S39_RS25060	COG0200	Binds to the 23S rRNA
K9S39_RS25070	COG0563	adenylate kinase activity
K9S39_RS25080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K9S39_RS25085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K9S39_RS25090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K9S39_RS25095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K9S39_RS25100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K9S39_RS25105	COG0202	RNA polymerase activity
K9S39_RS25110	COG0203	ribosomal protein L17
K9S39_RS25115	COG0101	tRNA pseudouridine synthase activity
K9S39_RS25125	COG0488	(ABC) transporter
K9S39_RS25130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K9S39_RS25135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K9S39_RS25140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K9S39_RS25145	COG1072	(Pantothenic acid kinase))
K9S39_RS25155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K9S39_RS25160	COG0736	holo-[acyl-carrier-protein] synthase activity
K9S39_RS25175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K9S39_RS25185	COG0802	atpase or kinase
K9S39_RS25210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K9S39_RS25225	COG0772	Belongs to the SEDS family
K9S39_RS25230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K9S39_RS25250	COG4221	oxidoreductase activity
K9S39_RS25260	COG0583	DNA-binding transcription factor activity
K9S39_RS25270	COG2197	response regulator
K9S39_RS25275	COG1595	DNA-templated transcription, initiation
K9S39_RS25285	COG0516	GMP reductase activity
K9S39_RS25295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K9S39_RS25315	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS25320	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS25335	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS25340	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS25355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9S39_RS25360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K9S39_RS25370	COG1024	Enoyl-CoA hydratase
K9S39_RS25420	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS25430	COG1309	transcriptional regulator
K9S39_RS25435	COG0515	serine threonine protein kinase
K9S39_RS25435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K9S39_RS25450	COG1024	Enoyl-CoA hydratase
K9S39_RS25555	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K9S39_RS25595	COG1686	Belongs to the peptidase S11 family
K9S39_RS25625	COG2205	protein histidine kinase activity
K9S39_RS25630	COG0514	ATP-dependent DNA helicase (RecQ)
K9S39_RS25650	COG2318	DinB family
K9S39_RS25685	COG0577	efflux transmembrane transporter activity
K9S39_RS25685	COG1136	(ABC) transporter
K9S39_RS25710	COG0657	acetylesterase activity
K9S39_RS25775	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K9S39_RS25795	COG0242	peptide deformylase activity
K9S39_RS25855	COG4974	Belongs to the 'phage' integrase family
K9S39_RS25925	COG1846	Transcriptional regulator
K9S39_RS26020	COG0730	response to heat
K9S39_RS26025	COG2188	Transcriptional regulator
K9S39_RS26035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K9S39_RS26050	COG0601	transmembrane transport
K9S39_RS26060	COG2226	methyltransferase
K9S39_RS26070	COG4948	Mandelate Racemase Muconate Lactonizing
K9S39_RS26075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K9S39_RS26105	COG1970	mechanosensitive ion channel activity
K9S39_RS26115	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K9S39_RS26130	COG3263	regulation of cellular component size
K9S39_RS26140	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K9S39_RS26145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K9S39_RS26155	COG0315	cyclic pyranopterin monophosphate synthase activity
K9S39_RS26160	COG0315	cyclic pyranopterin monophosphate synthase activity
K9S39_RS26160	COG0521	Mo-molybdopterin cofactor biosynthetic process
K9S39_RS26190	COG2207	Transcriptional regulator
K9S39_RS26205	COG3903	Transcriptional regulator
K9S39_RS26205	COG3629	intracellular signal transduction
K9S39_RS26210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K9S39_RS26235	COG3977	Valine--pyruvate aminotransferase
K9S39_RS26245	COG0662	Cupin 2, conserved barrel domain protein
K9S39_RS26255	COG1725	Transcriptional regulator
K9S39_RS26265	COG0708	Exodeoxyribonuclease III
K9S39_RS26530	COG0789	Transcriptional regulator
K9S39_RS26535	COG2072	flavoprotein involved in K transport
K9S39_RS26540	COG2267	carboxylic ester hydrolase activity
K9S39_RS26545	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS26555	COG4946	Tricorn protease homolog
K9S39_RS26555	COG0793	Belongs to the peptidase S41A family
K9S39_RS26590	COG0310	cobalt ion transport
K9S39_RS26600	COG1122	ATPase activity
K9S39_RS26635	COG0084	hydrolase, TatD family'
K9S39_RS26640	COG3583	domain protein
K9S39_RS26645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K9S39_RS26650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K9S39_RS26665	COG0488	(ABC) transporter
K9S39_RS26695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K9S39_RS26700	COG2197	response regulator
K9S39_RS26710	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS26715	COG1846	Transcriptional regulator
K9S39_RS26720	COG4106	trans-aconitate 2-methyltransferase activity
K9S39_RS26730	COG1309	transcriptional regulator
K9S39_RS26740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K9S39_RS26750	COG0193	aminoacyl-tRNA hydrolase activity
K9S39_RS26755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K9S39_RS26760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K9S39_RS26765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K9S39_RS26780	COG4585	Histidine kinase
K9S39_RS26810	COG0477	Major facilitator Superfamily
K9S39_RS26830	COG0457	Tetratricopeptide repeat
K9S39_RS26850	COG2267	carboxylic ester hydrolase activity
K9S39_RS26885	COG2124	cytochrome p450
K9S39_RS26900	COG0148	phosphopyruvate hydratase activity
K9S39_RS26925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K9S39_RS26930	COG0577	efflux transmembrane transporter activity
K9S39_RS26935	COG0577	efflux transmembrane transporter activity
K9S39_RS26935	COG1136	(ABC) transporter
K9S39_RS27020	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K9S39_RS27045	COG0183	Belongs to the thiolase family
K9S39_RS27050	COG2755	lipolytic protein G-D-S-L family
K9S39_RS27075	COG1609	Transcriptional regulator
K9S39_RS27120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K9S39_RS27135	COG1228	amidohydrolase
K9S39_RS27140	COG1191	sigma factor activity
K9S39_RS27145	COG1366	Belongs to the anti-sigma-factor antagonist family
K9S39_RS27175	COG3104	oligopeptide transport
K9S39_RS27180	COG0745	RESPONSE REGULATOR receiver
K9S39_RS27185	COG2205	protein histidine kinase activity
K9S39_RS27230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K9S39_RS27280	COG1316	TRANSCRIPTIONal
K9S39_RS27300	COG1316	TRANSCRIPTIONal
K9S39_RS27315	COG1316	TRANSCRIPTIONal
K9S39_RS27340	COG0778	Nitroreductase
K9S39_RS27340	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
K9S39_RS27345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K9S39_RS27380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K9S39_RS27385	COG2835	tetraacyldisaccharide 4'-kinase activity
K9S39_RS27395	COG1482	cell wall glycoprotein biosynthetic process
K9S39_RS27405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K9S39_RS27405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K9S39_RS27405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K9S39_RS27410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K9S39_RS27455	COG0714	Associated with various cellular activities
K9S39_RS27475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K9S39_RS27480	COG0745	RESPONSE REGULATOR receiver
K9S39_RS27485	COG5000	phosphorelay sensor kinase activity
K9S39_RS27485	COG5002	protein histidine kinase activity
K9S39_RS27490	COG0823	Involved in the tonB-independent uptake of proteins
K9S39_RS27495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K9S39_RS27500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K9S39_RS27505	COG2197	response regulator
K9S39_RS27510	COG3214	Protein conserved in bacteria
K9S39_RS27520	COG0653	protein targeting
K9S39_RS27540	COG2902	Dehydrogenase
K9S39_RS27545	COG1134	teichoic acid transport
K9S39_RS27555	COG1309	transcriptional regulator
K9S39_RS27560	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K9S39_RS27560	COG0463	Glycosyl transferase, family 2
K9S39_RS27570	COG0463	Glycosyl transferase, family 2
K9S39_RS27585	COG1215	transferase activity, transferring glycosyl groups
K9S39_RS27590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K9S39_RS27605	COG0395	ABC-type sugar transport system, permease component
K9S39_RS27610	COG1175	transmembrane transport
K9S39_RS27615	COG1653	transport
K9S39_RS27620	COG1716	ATPase activity
K9S39_RS27625	COG0515	serine threonine protein kinase
K9S39_RS27630	COG0515	serine threonine protein kinase
K9S39_RS27635	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K9S39_RS27650	COG2884	Cell division ATP-binding protein ftsE
K9S39_RS27655	COG2177	Part of the ABC transporter FtsEX involved in
K9S39_RS27660	COG0793	Belongs to the peptidase S41A family
K9S39_RS27665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K9S39_RS27680	COG0583	DNA-binding transcription factor activity
K9S39_RS27725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K9S39_RS27745	COG3973	AAA domain
K9S39_RS27755	COG0776	regulation of translation
K9S39_RS27770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K9S39_RS27775	COG1678	Uncharacterized ACR, COG1678
K9S39_RS27805	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K9S39_RS27820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9S39_RS27840	COG3480	Lon protease (S16) C-terminal proteolytic domain
K9S39_RS27850	COG1174	glycine betaine transport
K9S39_RS27860	COG1174	glycine betaine transport
K9S39_RS27870	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K9S39_RS27875	COG0277	FAD linked oxidase domain protein
K9S39_RS27880	COG0222	ribosome binding
K9S39_RS27915	COG1335	isochorismatase
K9S39_RS27925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K9S39_RS27935	COG1113	amino acid transport
K9S39_RS27960	COG1234	tRNA 3'-trailer cleavage
K9S39_RS27965	COG1263	PTS System
K9S39_RS27970	COG1263	PTS System
K9S39_RS27980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K9S39_RS27985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K9S39_RS27995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K9S39_RS28020	COG2205	protein histidine kinase activity
K9S39_RS28035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K9S39_RS28045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K9S39_RS28070	COG2733	membrane
K9S39_RS28080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K9S39_RS28145	COG0706	membrane insertase activity
K9S39_RS28155	COG0673	inositol 2-dehydrogenase activity
K9S39_RS28195	COG2186	Transcriptional regulator
K9S39_RS28225	COG1126	abc transporter atp-binding protein
K9S39_RS28230	COG0765	amino acid transport
K9S39_RS28235	COG0765	amino acid transport
K9S39_RS28250	COG0154	amidase activity
K9S39_RS28265	COG3473	Maleate cis-trans isomerase
K9S39_RS28270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K9S39_RS28330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K9S39_RS28395	COG0492	ferredoxin-NADP+ reductase activity
K9S39_RS28430	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS28455	COG0745	RESPONSE REGULATOR receiver
K9S39_RS28490	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K9S39_RS28495	COG4977	sequence-specific DNA binding
K9S39_RS28505	COG0589	response to stress
K9S39_RS28510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K9S39_RS28525	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS28540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K9S39_RS28545	COG1309	transcriptional regulator
K9S39_RS28555	COG1946	Acyl-CoA thioesterase
K9S39_RS28560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K9S39_RS28625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K9S39_RS28655	COG1309	transcriptional regulator
K9S39_RS28665	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K9S39_RS28685	COG1472	Belongs to the glycosyl hydrolase 3 family
K9S39_RS28705	COG0673	inositol 2-dehydrogenase activity
K9S39_RS28720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K9S39_RS28745	COG0673	inositol 2-dehydrogenase activity
K9S39_RS28765	COG2814	Major facilitator Superfamily
K9S39_RS28770	COG0673	inositol 2-dehydrogenase activity
K9S39_RS28790	COG3718	enzyme involved in inositol metabolism
K9S39_RS28795	COG3962	Belongs to the TPP enzyme family
K9S39_RS28815	COG1131	(ABC) transporter
K9S39_RS28825	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K9S39_RS28830	COG1289	transmembrane transporter activity
K9S39_RS28835	COG1077	Cell shape determining protein MreB Mrl
K9S39_RS28870	COG0629	single-stranded DNA binding
K9S39_RS28925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K9S39_RS28935	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS28945	COG1486	melibiose metabolic process
K9S39_RS28960	COG1846	Transcriptional regulator
K9S39_RS28960	COG1940	carbohydrate kinase activity
K9S39_RS28965	COG0668	transmembrane transport
K9S39_RS28975	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K9S39_RS29005	COG4266	Belongs to the allantoicase family
K9S39_RS29040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K9S39_RS29045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K9S39_RS29050	COG1113	amino acid transport
K9S39_RS29055	COG1113	amino acid transport
K9S39_RS29070	COG0698	ribose 5-phosphate isomerase
K9S39_RS29085	COG3594	Acyltransferase
K9S39_RS29115	COG0544	peptidyl-prolyl cis-trans isomerase activity
K9S39_RS29120	COG0740	serine-type endopeptidase activity
K9S39_RS29125	COG0740	serine-type endopeptidase activity
K9S39_RS29130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K9S39_RS29140	COG0525	valine-tRNA ligase activity
K9S39_RS29145	COG0285	dihydrofolate synthase activity
K9S39_RS29155	COG0105	UTP biosynthetic process
K9S39_RS29160	COG1077	Cell shape determining protein MreB Mrl
K9S39_RS29165	COG1792	Involved in formation and maintenance of cell shape
K9S39_RS29180	COG0772	Belongs to the SEDS family
K9S39_RS29210	COG1530	ribonuclease E activity
K9S39_RS29215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K9S39_RS29220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K9S39_RS29225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K9S39_RS29235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K9S39_RS29245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K9S39_RS29260	COG0501	Belongs to the peptidase M48B family
K9S39_RS29275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K9S39_RS29285	COG0799	negative regulation of ribosome biogenesis
K9S39_RS29290	COG0588	phosphoglycerate mutase activity
K9S39_RS29320	COG0495	leucyl-tRNA aminoacylation
K9S39_RS29330	COG1307	EDD domain protein, DegV family
K9S39_RS29340	COG1234	tRNA 3'-trailer cleavage
K9S39_RS29360	COG0268	Binds directly to 16S ribosomal RNA
K9S39_RS29365	COG0481	GTPase activity
K9S39_RS29370	COG1022	Amp-dependent synthetase and ligase
K9S39_RS29395	COG1420	regulation of RNA biosynthetic process
K9S39_RS29400	COG0484	heat shock protein binding
K9S39_RS29420	COG0537	adenosine 5'-monophosphoramidase activity
K9S39_RS29425	COG1234	tRNA 3'-trailer cleavage
K9S39_RS29450	COG1486	melibiose metabolic process
K9S39_RS29465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K9S39_RS29495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K9S39_RS29500	COG2211	Major facilitator Superfamily
K9S39_RS29520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K9S39_RS29560	COG1381	Involved in DNA repair and RecF pathway recombination
K9S39_RS29565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K9S39_RS29575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K9S39_RS29580	COG1121	(ABC) transporter
K9S39_RS29585	COG0803	Belongs to the bacterial solute-binding protein 9 family
K9S39_RS29590	COG0423	glycine-tRNA ligase activity
K9S39_RS29600	COG0667	Aldo Keto reductase
K9S39_RS29605	COG0477	Major facilitator Superfamily
K9S39_RS29630	COG0574	Belongs to the PEP-utilizing enzyme family
K9S39_RS29630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K9S39_RS29685	COG0531	amino acid
K9S39_RS29710	COG2146	nitrite reductase [NAD(P)H] activity
K9S39_RS29710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K9S39_RS29715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K9S39_RS29770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K9S39_RS29775	COG0243	molybdopterin cofactor binding
K9S39_RS29785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K9S39_RS29800	COG0358	DNA primase activity
K9S39_RS29805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K9S39_RS29810	COG1070	Carbohydrate kinase
K9S39_RS29885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K9S39_RS29895	COG1077	Cell shape determining protein MreB Mrl
K9S39_RS29930	COG4981	capsule polysaccharide biosynthetic process
K9S39_RS29935	COG0500	methyltransferase
K9S39_RS29960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K9S39_RS29970	COG2130	NADP-dependent
K9S39_RS29975	COG1764	response to oxidative stress
K9S39_RS29980	COG1609	Transcriptional regulator
K9S39_RS29985	COG1129	ABC transporter
K9S39_RS29995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K9S39_RS30035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K9S39_RS30040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K9S39_RS30045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9S39_RS30070	COG0789	Transcriptional regulator
K9S39_RS30085	COG2197	response regulator
K9S39_RS30090	COG4585	Histidine kinase
K9S39_RS30105	COG1309	transcriptional regulator
K9S39_RS30110	COG0477	Major facilitator Superfamily
K9S39_RS30120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K9S39_RS30125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K9S39_RS30170	COG1358	cellular component organization or biogenesis
K9S39_RS30195	COG4948	Mandelate Racemase Muconate Lactonizing
K9S39_RS30450	COG0302	gtp cyclohydrolase
K9S39_RS30455	COG0602	queuosine metabolic process
K9S39_RS30595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K9S39_RS30630	COG0454	-acetyltransferase
K9S39_RS30635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9S39_RS30680	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K9S39_RS30690	COG0367	asparagine synthase
K9S39_RS30710	COG3328	transposase activity
K9S39_RS30790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K9S39_RS30900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K9S39_RS30990	COG3723	Recombinational DNA repair protein, rece pathway
K9S39_RS31080	COG1127	ABC transporter
K9S39_RS31085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K9S39_RS31145	COG0596	Alpha beta hydrolase
K9S39_RS31155	COG1072	(Pantothenic acid kinase))
K9S39_RS31235	COG2124	cytochrome p450
K9S39_RS31240	COG0183	Belongs to the thiolase family
K9S39_RS31255	COG3845	ABC transporter
K9S39_RS31275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9S39_RS31290	COG1309	transcriptional regulator
K9S39_RS31295	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS31315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K9S39_RS31335	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS31345	COG2030	dehydratase
K9S39_RS31355	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS31370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K9S39_RS31385	COG0800	Aldolase
K9S39_RS31390	COG3022	response to hydroperoxide
K9S39_RS31405	COG0789	Transcriptional regulator
K9S39_RS31430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9S39_RS31445	COG2267	carboxylic ester hydrolase activity
K9S39_RS31450	COG3226	Transcriptional regulator
K9S39_RS31455	COG2755	lipolytic protein G-D-S-L family
K9S39_RS31465	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS31485	COG3540	Alkaline phosphatase
K9S39_RS31490	COG2814	Major facilitator Superfamily
K9S39_RS31495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K9S39_RS31525	COG0672	)-iron permease
K9S39_RS31530	COG2837	iron assimilation
K9S39_RS31545	COG5398	heme oxygenase
K9S39_RS31570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K9S39_RS31590	COG0395	ABC-type sugar transport system, permease component
K9S39_RS31605	COG1994	Peptidase M50
K9S39_RS31625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K9S39_RS31630	COG0477	Major facilitator Superfamily
K9S39_RS31635	COG1309	transcriptional regulator
K9S39_RS31645	COG2814	Major facilitator Superfamily
K9S39_RS31650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K9S39_RS31650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K9S39_RS31655	COG2132	Multicopper oxidase
K9S39_RS31670	COG2267	carboxylic ester hydrolase activity
K9S39_RS31675	COG0174	glutamine synthetase
K9S39_RS31680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K9S39_RS31690	COG1609	Transcriptional regulator
K9S39_RS31695	COG0366	Alpha amylase catalytic
K9S39_RS31700	COG2182	Extracellular solute-binding protein
K9S39_RS31705	COG1175	transmembrane transport
K9S39_RS31710	COG3833	ABC-type maltose transport systems, permease component
K9S39_RS31715	COG0366	Alpha amylase catalytic
K9S39_RS31780	COG0745	RESPONSE REGULATOR receiver
K9S39_RS31815	COG1695	Transcriptional regulator
K9S39_RS31820	COG0446	pyridine nucleotide-disulphide oxidoreductase
K9S39_RS31820	COG1902	pentaerythritol trinitrate reductase activity
K9S39_RS31840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K9S39_RS31915	COG2226	methyltransferase
K9S39_RS31970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K9S39_RS31975	COG0321	lipoyl(octanoyl) transferase activity
K9S39_RS32010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K9S39_RS32020	COG0508	dehydrogenase complex catalyzes the overall conversion of
K9S39_RS32025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K9S39_RS32030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K9S39_RS32035	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K9S39_RS32045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K9S39_RS32045	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K9S39_RS32050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K9S39_RS32090	COG4585	Histidine kinase
K9S39_RS32095	COG2197	response regulator
K9S39_RS32100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K9S39_RS32130	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K9S39_RS32150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K9S39_RS32160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K9S39_RS32165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K9S39_RS32175	COG1376	ErfK ybiS ycfS ynhG family protein
K9S39_RS32185	COG1845	cytochrome c oxidase, subunit III
K9S39_RS32190	COG2010	Cytochrome c
K9S39_RS32195	COG0723	plastoquinol--plastocyanin reductase activity
K9S39_RS32200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K9S39_RS32205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K9S39_RS32210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K9S39_RS32255	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS32275	COG0003	Pfam Anion-transporting ATPase
K9S39_RS32285	COG1940	carbohydrate kinase activity
K9S39_RS32315	COG2197	response regulator
K9S39_RS32320	COG0205	6-phosphofructokinase activity
K9S39_RS32325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K9S39_RS32335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K9S39_RS32340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9S39_RS32345	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K9S39_RS32355	COG2193	ferroxidase activity
K9S39_RS32360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K9S39_RS32365	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K9S39_RS32370	COG0515	serine threonine protein kinase
K9S39_RS32370	COG2815	serine threonine protein kinase
K9S39_RS32375	COG2022	thiamine diphosphate biosynthetic process
K9S39_RS32385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9S39_RS32385	COG2022	thiamine diphosphate biosynthetic process
K9S39_RS32390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K9S39_RS32400	COG0352	thiamine-phosphate diphosphorylase activity
K9S39_RS32415	COG1233	COG1233 Phytoene dehydrogenase and related
K9S39_RS32425	COG1309	transcriptional regulator
K9S39_RS32435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K9S39_RS32445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K9S39_RS32465	COG0714	Associated with various cellular activities
K9S39_RS32475	COG0275	rRNA processing
K9S39_RS32490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K9S39_RS32500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K9S39_RS32505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K9S39_RS32515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K9S39_RS32520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K9S39_RS32540	COG1799	cell septum assembly
K9S39_RS32550	COG3599	regulation of cell shape
K9S39_RS32555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K9S39_RS32565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K9S39_RS32620	COG0587	DNA-directed DNA polymerase activity
K9S39_RS32630	COG1432	Conserved Protein
K9S39_RS32650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K9S39_RS32665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K9S39_RS32670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K9S39_RS32675	COG0131	Imidazoleglycerol-phosphate dehydratase
K9S39_RS32685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K9S39_RS32690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K9S39_RS32695	COG0251	oxidation-reduction process
K9S39_RS32700	COG0107	imidazoleglycerol-phosphate synthase activity
K9S39_RS32705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K9S39_RS32710	COG1053	succinate dehydrogenase
K9S39_RS32720	COG0583	DNA-binding transcription factor activity
K9S39_RS32730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K9S39_RS32735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K9S39_RS32755	COG0134	indole-3-glycerol-phosphate synthase activity
K9S39_RS32760	COG0133	tryptophan synthase activity
K9S39_RS32765	COG0159	tryptophan synthase activity
K9S39_RS32775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K9S39_RS32780	COG2301	Belongs to the HpcH HpaI aldolase family
K9S39_RS32785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K9S39_RS32815	COG0067	glutamate synthase
K9S39_RS32815	COG0069	glutamate synthase activity
K9S39_RS32815	COG0070	glutamate synthase
K9S39_RS32830	COG0640	Transcriptional regulator
K9S39_RS32845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K9S39_RS32870	COG1470	cell adhesion involved in biofilm formation
K9S39_RS32870	COG0366	Alpha amylase catalytic
K9S39_RS32940	COG2050	protein possibly involved in aromatic compounds catabolism
K9S39_RS32975	COG1643	Atp-dependent helicase
K9S39_RS32980	COG2226	methyltransferase
K9S39_RS33000	COG0237	dephospho-CoA kinase activity
K9S39_RS33025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K9S39_RS33080	COG0584	glycerophosphoryl diester phosphodiesterase
K9S39_RS33085	COG0556	nucleotide-excision repair
K9S39_RS33130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K9S39_RS33140	COG1609	Transcriptional regulator
K9S39_RS33165	COG0322	excinuclease ABC activity
K9S39_RS33170	COG1660	Displays ATPase and GTPase activities
K9S39_RS33175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K9S39_RS33180	COG1481	regulation of sporulation
K9S39_RS33185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K9S39_RS33190	COG0126	phosphoglycerate kinase activity
K9S39_RS33195	COG0149	triose-phosphate isomerase activity
K9S39_RS33200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K9S39_RS33210	COG0166	Belongs to the GPI family
K9S39_RS33215	COG0363	glucosamine-6-phosphate deaminase activity
K9S39_RS33230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K9S39_RS33240	COG0109	protoheme IX farnesyltransferase activity
K9S39_RS33255	COG1612	heme a metabolic process
K9S39_RS33265	COG1131	(ABC) transporter
K9S39_RS33280	COG0719	Fe-S assembly protein
K9S39_RS33290	COG0396	ATPase activity
K9S39_RS33295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K9S39_RS33300	COG0822	iron-sulfur transferase activity
K9S39_RS33305	COG2151	metal-sulfur cluster biosynthetic enzyme
K9S39_RS33310	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS33315	COG2076	Multidrug Resistance protein
K9S39_RS33320	COG3226	Transcriptional regulator
K9S39_RS33325	COG2171	N-acyltransferase activity
K9S39_RS33375	COG2261	transglycosylase associated protein
K9S39_RS33380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9S39_RS33405	COG4585	Histidine kinase
K9S39_RS33415	COG1414	Transcriptional regulator
K9S39_RS33430	COG2226	methyltransferase
K9S39_RS33445	COG5285	phytanoyl-CoA dioxygenase
K9S39_RS33450	COG1917	Cupin 2, conserved barrel domain protein
K9S39_RS33455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K9S39_RS33480	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
K9S39_RS33490	COG1797	cobyrinic acid a,c-diamide synthase activity
K9S39_RS33495	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K9S39_RS33505	COG1492	cobalamin metabolic process
K9S39_RS33510	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K9S39_RS33540	COG0235	Class ii aldolase
K9S39_RS33565	COG0488	(ABC) transporter
K9S39_RS33575	COG1024	Enoyl-CoA hydratase
K9S39_RS33585	COG1302	Protein conserved in bacteria
K9S39_RS33615	COG3387	PFAM Glycoside hydrolase 15-related
K9S39_RS33630	COG2176	DNA-directed DNA polymerase activity
K9S39_RS33665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K9S39_RS33670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K9S39_RS33690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K9S39_RS33705	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS33710	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K9S39_RS33720	COG2186	Transcriptional regulator
K9S39_RS33740	COG3830	Belongs to the UPF0237 family
K9S39_RS33740	COG0560	Phosphoserine phosphatase
K9S39_RS33745	COG0842	Transport permease protein
K9S39_RS33745	COG1131	(ABC) transporter
K9S39_RS33745	COG1716	ATPase activity
K9S39_RS33770	COG2197	response regulator
K9S39_RS33790	COG1119	ATPase activity
K9S39_RS33815	COG1881	PFAM PEBP family protein
K9S39_RS33825	COG2094	Belongs to the DNA glycosylase MPG family
K9S39_RS33855	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS33870	COG3486	L-lysine 6-monooxygenase (NADPH) activity
K9S39_RS33885	COG0647	UMP catabolic process
K9S39_RS33900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K9S39_RS33905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K9S39_RS33910	COG1120	ATPase activity
K9S39_RS33935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K9S39_RS33960	COG0497	DNA recombination
K9S39_RS34010	COG3387	PFAM Glycoside hydrolase 15-related
K9S39_RS34015	COG0504	CTP synthase activity
K9S39_RS34020	COG0494	nUDIX hydrolase
K9S39_RS34030	COG0686	Belongs to the AlaDH PNT family
K9S39_RS34045	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K9S39_RS34050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K9S39_RS34055	COG1187	pseudouridine synthase activity
K9S39_RS34080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K9S39_RS34090	COG1160	GTP binding
K9S39_RS34105	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS34120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K9S39_RS34130	COG0671	phosphoesterase, PA-phosphatase related
K9S39_RS34140	COG0477	Major facilitator Superfamily
K9S39_RS34145	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS34150	COG1799	cell septum assembly
K9S39_RS34165	COG0330	HflC and HflK could
K9S39_RS34185	COG0587	DNA-directed DNA polymerase activity
K9S39_RS34190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K9S39_RS34215	COG0531	amino acid
K9S39_RS34220	COG1522	sequence-specific DNA binding
K9S39_RS34250	COG0456	acetyltransferase
K9S39_RS34250	COG0454	-acetyltransferase
K9S39_RS34255	COG0367	asparagine synthase
K9S39_RS34260	COG1725	Transcriptional regulator
K9S39_RS34265	COG1834	amidinotransferase
K9S39_RS34325	COG2188	Transcriptional regulator
K9S39_RS34330	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K9S39_RS34335	COG0243	molybdopterin cofactor binding
K9S39_RS34340	COG2851	Citrate transporter
K9S39_RS34360	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS34415	COG3876	Protein conserved in bacteria
K9S39_RS34425	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS34430	COG1309	transcriptional regulator
K9S39_RS34435	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS34455	COG2149	membrane
K9S39_RS34460	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K9S39_RS34500	COG2205	protein histidine kinase activity
K9S39_RS34505	COG0745	RESPONSE REGULATOR receiver
K9S39_RS34515	COG2124	cytochrome p450
K9S39_RS34520	COG0488	(ABC) transporter
K9S39_RS34550	COG2271	Major facilitator Superfamily
K9S39_RS34555	COG0659	secondary active sulfate transmembrane transporter activity
K9S39_RS34585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K9S39_RS34600	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K9S39_RS34610	COG3973	AAA domain
K9S39_RS34625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K9S39_RS34655	COG0667	Aldo Keto reductase
K9S39_RS34660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K9S39_RS34670	COG0598	Magnesium transport protein CorA
K9S39_RS34690	COG0215	cysteine-tRNA ligase activity
K9S39_RS34710	COG2186	Transcriptional regulator
K9S39_RS34715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K9S39_RS34720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K9S39_RS34725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K9S39_RS34730	COG1414	Transcriptional regulator
K9S39_RS34735	COG0646	methionine synthase
K9S39_RS34735	COG1410	methionine synthase
K9S39_RS34740	COG0546	phosphoglycolate phosphatase activity
K9S39_RS34745	COG4166	transmembrane transport
K9S39_RS34755	COG2197	response regulator
K9S39_RS34765	COG0517	IMP dehydrogenase activity
K9S39_RS34765	COG1994	Peptidase M50
K9S39_RS34785	COG1222	aaa ATPase
K9S39_RS34790	COG4122	O-methyltransferase activity
K9S39_RS34805	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K9S39_RS34810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K9S39_RS34815	COG1609	Transcriptional regulator
K9S39_RS34825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K9S39_RS34840	COG2378	regulation of single-species biofilm formation
K9S39_RS34860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K9S39_RS34865	COG0805	protein transport
K9S39_RS34880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K9S39_RS34910	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K9S39_RS34915	COG0531	amino acid
K9S39_RS34920	COG2186	Transcriptional regulator
K9S39_RS34935	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS34955	COG1404	Belongs to the peptidase S8 family
K9S39_RS34965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K9S39_RS34975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K9S39_RS34980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K9S39_RS34985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K9S39_RS34990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K9S39_RS34995	COG5002	protein histidine kinase activity
K9S39_RS35000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K9S39_RS35005	COG0072	phenylalanine-tRNA ligase activity
K9S39_RS35005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K9S39_RS35020	COG0494	nUDIX hydrolase
K9S39_RS35035	COG1649	PFAM Uncharacterised BCR, COG1649
K9S39_RS35045	COG0697	spore germination
K9S39_RS35080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K9S39_RS35085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K9S39_RS35090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K9S39_RS35095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K9S39_RS35100	COG1438	arginine binding
K9S39_RS35120	COG0137	argininosuccinate synthase activity
K9S39_RS35125	COG0165	Argininosuccinate lyase
K9S39_RS35135	COG0477	Major facilitator Superfamily
K9S39_RS35145	COG0204	Acyl-transferase
K9S39_RS35145	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS35150	COG0584	glycerophosphoryl diester phosphodiesterase
K9S39_RS35175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K9S39_RS35180	COG2011	ABC-type metal ion transport system permease component
K9S39_RS35185	COG1464	Belongs to the NlpA lipoprotein family
K9S39_RS35200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K9S39_RS35205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K9S39_RS35205	COG1648	precorrin-2 dehydrogenase activity
K9S39_RS35225	COG2843	Capsule synthesis protein
K9S39_RS35235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K9S39_RS35315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K9S39_RS35325	COG0454	-acetyltransferase
K9S39_RS35325	COG0456	acetyltransferase
K9S39_RS35375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K9S39_RS35390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K9S39_RS35415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K9S39_RS35420	COG1560	Kdo2-lipid A biosynthetic process
K9S39_RS35425	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS35435	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K9S39_RS35440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K9S39_RS35445	COG0217	transcriptional regulatory protein
K9S39_RS35450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K9S39_RS35455	COG0632	four-way junction helicase activity
K9S39_RS35460	COG2255	four-way junction helicase activity
K9S39_RS35470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K9S39_RS35475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K9S39_RS35480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K9S39_RS35485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K9S39_RS35490	COG1196	nuclear chromosome segregation
K9S39_RS35495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K9S39_RS35505	COG0124	histidyl-tRNA synthetase
K9S39_RS35525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K9S39_RS35545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K9S39_RS35550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K9S39_RS35560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K9S39_RS35565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K9S39_RS35570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K9S39_RS35575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K9S39_RS35580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K9S39_RS35590	COG0006	proline dipeptidase activity
K9S39_RS35595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K9S39_RS35600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K9S39_RS35610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K9S39_RS35615	COG0540	Belongs to the ATCase OTCase family
K9S39_RS35620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K9S39_RS35630	COG0505	Belongs to the CarA family
K9S39_RS35635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K9S39_RS35640	COG0167	dihydroorotate dehydrogenase activity
K9S39_RS35645	COG0284	orotidine-5'-phosphate decarboxylase activity
K9S39_RS35670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K9S39_RS35685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K9S39_RS35695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K9S39_RS35700	COG2390	Transcriptional regulator
K9S39_RS35720	COG0531	amino acid
K9S39_RS35735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K9S39_RS35760	COG1090	epimerase
K9S39_RS35775	COG3201	nicotinamide mononucleotide transporter
K9S39_RS35780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K9S39_RS35780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K9S39_RS35785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K9S39_RS35790	COG0140	phosphoribosyl-ATP diphosphatase activity
K9S39_RS35795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K9S39_RS35855	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K9S39_RS35860	COG2192	nodulation
K9S39_RS35870	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K9S39_RS35875	COG4106	trans-aconitate 2-methyltransferase activity
K9S39_RS35895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K9S39_RS35935	COG0300	oxidoreductase activity
K9S39_RS35940	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS35980	COG0655	NAD(P)H dehydrogenase (quinone) activity
K9S39_RS35985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9S39_RS35995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K9S39_RS36015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K9S39_RS36020	COG0156	8-amino-7-oxononanoate synthase activity
K9S39_RS36025	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS36050	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS36165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K9S39_RS36175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K9S39_RS36195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K9S39_RS36200	COG4974	Belongs to the 'phage' integrase family
K9S39_RS36270	COG3586	endonuclease activity
K9S39_RS36385	COG0009	L-threonylcarbamoyladenylate synthase
K9S39_RS36405	COG0038	chloride channel
K9S39_RS36470	COG3344	reverse transcriptase
K9S39_RS36480	COG2801	Transposase and inactivated derivatives
K9S39_RS36520	COG0671	phosphoesterase, PA-phosphatase related
K9S39_RS36545	COG0584	glycerophosphoryl diester phosphodiesterase
K9S39_RS36595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K9S39_RS36600	COG2318	DinB family
K9S39_RS36630	COG0494	nUDIX hydrolase
K9S39_RS36645	COG4585	Histidine kinase
K9S39_RS36650	COG2197	response regulator
K9S39_RS36670	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS36675	COG1940	carbohydrate kinase activity
K9S39_RS36720	COG2755	lipolytic protein G-D-S-L family
K9S39_RS36835	COG1349	DNA-binding transcription factor activity
K9S39_RS36845	COG0464	growth
K9S39_RS36865	COG0633	Ferredoxin
K9S39_RS36865	COG3217	Mosc domain protein beta barrel domain protein
K9S39_RS36880	COG0463	Glycosyl transferase, family 2
K9S39_RS36885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K9S39_RS36920	COG0513	Belongs to the DEAD box helicase family
K9S39_RS36925	COG1278	Cold shock
K9S39_RS36930	COG1793	dna ligase
K9S39_RS36945	COG1063	alcohol dehydrogenase
K9S39_RS36950	COG0395	ABC-type sugar transport system, permease component
K9S39_RS36965	COG1349	DNA-binding transcription factor activity
K9S39_RS37000	COG1461	Dihydroxyacetone kinase
K9S39_RS37005	COG2376	Dihydroxyacetone kinase
K9S39_RS37015	COG1254	Belongs to the acylphosphatase family
K9S39_RS37025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K9S39_RS37040	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
K9S39_RS37055	COG0243	molybdopterin cofactor binding
K9S39_RS37090	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS37100	COG0515	serine threonine protein kinase
K9S39_RS37115	COG2070	2-Nitropropane dioxygenase
K9S39_RS37155	COG1024	Enoyl-CoA hydratase
K9S39_RS37220	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS37245	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K9S39_RS37290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K9S39_RS37305	COG1984	allophanate hydrolase subunit 2
K9S39_RS37310	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS37315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K9S39_RS37320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K9S39_RS37340	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K9S39_RS37365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9S39_RS37385	COG2146	nitrite reductase [NAD(P)H] activity
K9S39_RS37420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K9S39_RS37425	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K9S39_RS37445	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K9S39_RS37455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K9S39_RS37465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K9S39_RS37495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K9S39_RS37535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K9S39_RS37545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K9S39_RS37545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K9S39_RS37580	COG1695	Transcriptional regulator
K9S39_RS37605	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS37635	COG0697	spore germination
K9S39_RS37640	COG0583	DNA-binding transcription factor activity
K9S39_RS37645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K9S39_RS37645	COG0825	malonyl-CoA metabolic process
K9S39_RS37650	COG0318	PFAM AMP-dependent synthetase and ligase
K9S39_RS37695	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K9S39_RS37720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K9S39_RS37725	COG1132	(ABC) transporter
K9S39_RS37735	COG0386	Belongs to the glutathione peroxidase family
K9S39_RS37905	COG1120	ATPase activity
K9S39_RS37910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K9S39_RS37915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K9S39_RS37925	COG2217	Heavy metal translocating P-type atpase
K9S39_RS37930	COG1937	Protein conserved in bacteria
K9S39_RS37965	COG0667	Aldo Keto reductase
K9S39_RS38000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K9S39_RS38020	COG3938	Belongs to the proline racemase family
K9S39_RS38025	COG1802	Transcriptional regulator
K9S39_RS38055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K9S39_RS38065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K9S39_RS38065	COG1796	DNA polymerase
K9S39_RS38090	COG0438	transferase activity, transferring glycosyl groups
K9S39_RS38120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K9S39_RS38155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K9S39_RS38165	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K9S39_RS38170	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS38175	COG3433	isochorismatase activity
K9S39_RS38175	COG1535	isochorismatase
K9S39_RS38185	COG2382	esterase
K9S39_RS38220	COG3585	molybdate ion transport
K9S39_RS38260	COG0477	Major facilitator Superfamily
K9S39_RS38300	COG0659	secondary active sulfate transmembrane transporter activity
K9S39_RS38305	COG0745	RESPONSE REGULATOR receiver
K9S39_RS38335	COG1063	alcohol dehydrogenase
K9S39_RS38340	COG0156	8-amino-7-oxononanoate synthase activity
K9S39_RS38345	COG0583	DNA-binding transcription factor activity
K9S39_RS38350	COG1796	DNA polymerase
K9S39_RS38350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K9S39_RS38380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K9S39_RS38385	COG1120	ATPase activity
K9S39_RS38395	COG2124	cytochrome p450
K9S39_RS38435	COG4941	Belongs to the sigma-70 factor family
K9S39_RS38450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K9S39_RS38480	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K9S39_RS38520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K9S39_RS38525	COG1993	acr, cog1993
K9S39_RS38530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K9S39_RS38535	COG3973	AAA domain
K9S39_RS38565	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K9S39_RS38585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K9S39_RS38590	COG1573	uracil-dna glycosylase
K9S39_RS38635	COG2340	Cysteine-rich secretory protein family
K9S39_RS38645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K9S39_RS38650	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K9S39_RS38655	COG2080	2 iron, 2 sulfur cluster binding
K9S39_RS38675	COG0009	L-threonylcarbamoyladenylate synthase
K9S39_RS38700	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS38745	COG0517	IMP dehydrogenase activity
K9S39_RS38745	COG0516	GMP reductase activity
K9S39_RS38810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K9S39_RS38820	COG2226	methyltransferase
K9S39_RS38830	COG1595	DNA-templated transcription, initiation
K9S39_RS38840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K9S39_RS38880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K9S39_RS38900	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS39100	COG2267	carboxylic ester hydrolase activity
K9S39_RS39120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K9S39_RS39130	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K9S39_RS39150	COG0569	domain protein
K9S39_RS39155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K9S39_RS39205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K9S39_RS39240	COG0384	phenazine biosynthesis protein PhzF
K9S39_RS39260	COG1309	transcriptional regulator
K9S39_RS39280	COG3479	Phenolic acid decarboxylase
K9S39_RS39320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K9S39_RS39330	COG4213	ABC transporter substrate-binding protein
K9S39_RS39335	COG4213	ABC transporter substrate-binding protein
K9S39_RS39340	COG4221	oxidoreductase activity
K9S39_RS39350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K9S39_RS39375	COG2706	6-phosphogluconolactonase activity
K9S39_RS39385	COG2971	BadF BadG BcrA BcrD
K9S39_RS39395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K9S39_RS39405	COG1902	pentaerythritol trinitrate reductase activity
K9S39_RS39425	COG1309	transcriptional regulator
K9S39_RS39435	COG0477	Major facilitator Superfamily
K9S39_RS39440	COG1957	nucleoside hydrolase
K9S39_RS39445	COG1609	Transcriptional regulator
K9S39_RS39515	COG0076	glutamate decarboxylase activity
K9S39_RS39535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K9S39_RS39555	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS39590	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K9S39_RS39600	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K9S39_RS39615	COG0300	oxidoreductase activity
K9S39_RS39640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9S39_RS39650	COG1012	belongs to the aldehyde dehydrogenase family
K9S39_RS39670	COG1309	transcriptional regulator
K9S39_RS39680	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS39710	COG0463	Glycosyl transferase, family 2
K9S39_RS39755	COG3012	SEC-C Motif Domain Protein
K9S39_RS39765	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K9S39_RS39770	COG1793	dna ligase
K9S39_RS39770	COG3285	dna ligase
K9S39_RS39795	COG2356	endonuclease I
K9S39_RS39800	COG1278	Cold shock
K9S39_RS39835	COG0395	ABC-type sugar transport system, permease component
K9S39_RS39840	COG1175	transmembrane transport
K9S39_RS39845	COG1653	transport
K9S39_RS39850	COG1609	Transcriptional regulator
K9S39_RS39860	COG0739	heme binding
K9S39_RS39885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K9S39_RS39895	COG1846	Transcriptional regulator
K9S39_RS39900	COG1764	response to oxidative stress
K9S39_RS39930	COG1349	DNA-binding transcription factor activity
K9S39_RS39940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K9S39_RS39955	COG4106	trans-aconitate 2-methyltransferase activity
K9S39_RS39960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K9S39_RS39965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K9S39_RS39985	COG0519	Catalyzes the synthesis of GMP from XMP
K9S39_RS39995	COG1028	Short-chain dehydrogenase reductase Sdr
K9S39_RS40000	COG2814	Major facilitator Superfamily
K9S39_RS40015	COG0154	amidase activity
K9S39_RS40030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K9S39_RS40040	COG2264	protein methyltransferase activity
K9S39_RS40145	COG0346	lactoylglutathione lyase activity
K9S39_RS40150	COG0181	hydroxymethylbilane synthase activity
K9S39_RS40235	COG0456	acetyltransferase
K9S39_RS40240	COG0436	Aminotransferase
K9S39_RS40265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K9S39_RS40270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K9S39_RS40315	COG2124	cytochrome p450
K9S39_RS40350	COG0432	Pfam Uncharacterised protein family UPF0047
K9S39_RS40355	COG1201	RNA secondary structure unwinding
K9S39_RS40415	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K9S39_RS40430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K9S39_RS40440	COG4638	Rieske (2fe-2S)
K9S39_RS40470	COG1960	acyl-CoA dehydrogenase activity
K9S39_RS40485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K9S39_RS40500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K9S39_RS40505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K9S39_RS40535	COG1131	(ABC) transporter
K9S39_RS40545	COG1476	TRANSCRIPTIONal
K9S39_RS40585	COG2311	Membrane
K9S39_RS40600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K9S39_RS40625	COG1278	Cold shock
K9S39_RS40710	COG2018	Roadblock/LC7 domain
K9S39_RS40715	COG0642	Histidine kinase
K9S39_RS40725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K9S39_RS40765	COG3708	Transcriptional regulator
K9S39_RS40765	COG2207	Transcriptional regulator
K9S39_RS40975	COG0154	amidase activity
K9S39_RS40995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9S39_RS41040	COG0604	alcohol dehydrogenase
K9S39_RS41040	COG3321	synthase
K9S39_RS41065	COG1846	Transcriptional regulator
K9S39_RS41070	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS41080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K9S39_RS41085	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K9S39_RS41095	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS41100	COG0596	Alpha beta hydrolase
K9S39_RS41110	COG1595	DNA-templated transcription, initiation
K9S39_RS41135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K9S39_RS41150	COG3547	Transposase (IS116 IS110 IS902 family)
K9S39_RS41175	COG0574	Belongs to the PEP-utilizing enzyme family
K9S39_RS41175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K9S39_RS41185	COG0151	Belongs to the GarS family
K9S39_RS41320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K9S39_RS41325	COG2226	methyltransferase
K9S39_RS41415	COG0494	nUDIX hydrolase
K9S39_RS41510	COG1073	alpha beta
K9S39_RS41525	COG1131	(ABC) transporter
K9S39_RS41550	COG0596	Alpha beta hydrolase
K9S39_RS41570	COG1132	(ABC) transporter
K9S39_RS41610	COG2197	response regulator
K9S39_RS41715	COG2259	Doxx family