locus-tag	class	description
GHR20_RS00005	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS00035	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS00095	COG0596	Alpha beta hydrolase
GHR20_RS00115	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHR20_RS00140	COG0561	phosphatase activity
GHR20_RS00165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GHR20_RS00170	COG3845	ABC transporter
GHR20_RS00175	COG1122	ATPase activity
GHR20_RS00185	COG1090	epimerase
GHR20_RS00200	COG0784	Response regulator, receiver
GHR20_RS00205	COG4251	negative regulation of phosphorylation
GHR20_RS00210	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS00215	COG1982	Orn Lys Arg decarboxylase major
GHR20_RS00225	COG0006	proline dipeptidase activity
GHR20_RS00230	COG0006	proline dipeptidase activity
GHR20_RS00235	COG1802	Transcriptional regulator
GHR20_RS00275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS00285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS00295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS00340	COG3903	Transcriptional regulator
GHR20_RS00340	COG3629	intracellular signal transduction
GHR20_RS00360	COG2197	response regulator
GHR20_RS00380	COG1518	maintenance of DNA repeat elements
GHR20_RS00385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GHR20_RS00395	COG3938	Belongs to the proline racemase family
GHR20_RS00400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHR20_RS00410	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHR20_RS00410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GHR20_RS00415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHR20_RS00470	COG4934	collagen metabolic process
GHR20_RS00475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GHR20_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS00500	COG1309	transcriptional regulator
GHR20_RS00510	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GHR20_RS00515	COG0515	serine threonine protein kinase
GHR20_RS00525	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GHR20_RS00540	COG0142	geranyltranstransferase activity
GHR20_RS00600	COG0151	Belongs to the GarS family
GHR20_RS00610	COG2814	Major facilitator Superfamily
GHR20_RS00630	COG4122	O-methyltransferase activity
GHR20_RS00725	COG0596	Alpha beta hydrolase
GHR20_RS00735	COG0583	DNA-binding transcription factor activity
GHR20_RS00775	COG0604	alcohol dehydrogenase
GHR20_RS00805	COG0702	epimerase
GHR20_RS00810	COG1733	regulation of RNA biosynthetic process
GHR20_RS00845	COG0745	RESPONSE REGULATOR receiver
GHR20_RS00870	COG0483	inositol monophosphate 1-phosphatase activity
GHR20_RS00910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GHR20_RS00915	COG2936	dipeptidyl-peptidase activity
GHR20_RS00930	COG0583	DNA-binding transcription factor activity
GHR20_RS00960	COG0477	Major facilitator Superfamily
GHR20_RS00975	COG4977	sequence-specific DNA binding
GHR20_RS00990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GHR20_RS01020	COG4585	Histidine kinase
GHR20_RS01025	COG2197	response regulator
GHR20_RS01030	COG0583	DNA-binding transcription factor activity
GHR20_RS01045	COG1309	transcriptional regulator
GHR20_RS01085	COG0667	Aldo Keto reductase
GHR20_RS01105	COG2197	response regulator
GHR20_RS01130	COG2318	DinB family
GHR20_RS01140	COG0745	RESPONSE REGULATOR receiver
GHR20_RS01145	COG5002	protein histidine kinase activity
GHR20_RS01165	COG2205	protein histidine kinase activity
GHR20_RS01190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GHR20_RS01215	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS01220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GHR20_RS01230	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS01235	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GHR20_RS01265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHR20_RS01275	COG0673	inositol 2-dehydrogenase activity
GHR20_RS01350	COG2072	flavoprotein involved in K transport
GHR20_RS01370	COG0589	response to stress
GHR20_RS01375	COG2706	6-phosphogluconolactonase activity
GHR20_RS01385	COG3387	PFAM Glycoside hydrolase 15-related
GHR20_RS01390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GHR20_RS01395	COG3265	gluconokinase activity
GHR20_RS01420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHR20_RS01420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHR20_RS01425	COG0730	response to heat
GHR20_RS01435	COG5297	Belongs to the glycosyl hydrolase family 6
GHR20_RS01440	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GHR20_RS01450	COG0477	Major facilitator Superfamily
GHR20_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS01485	COG1309	transcriptional regulator
GHR20_RS01505	COG1846	Transcriptional regulator
GHR20_RS01510	COG2814	Major facilitator Superfamily
GHR20_RS01530	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS01535	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS01540	COG2172	sigma factor antagonist activity
GHR20_RS01580	COG0248	Ppx GppA phosphatase
GHR20_RS01600	COG3469	chitinase activity
GHR20_RS01610	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GHR20_RS01620	COG2814	Major facilitator Superfamily
GHR20_RS01670	COG1278	Cold shock
GHR20_RS01680	COG2197	response regulator
GHR20_RS01685	COG4585	Histidine kinase
GHR20_RS01750	COG2172	sigma factor antagonist activity
GHR20_RS01750	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS01750	COG2208	phosphoserine phosphatase activity
GHR20_RS01755	COG0590	tRNA wobble adenosine to inosine editing
GHR20_RS01770	COG0583	DNA-binding transcription factor activity
GHR20_RS01775	COG3387	PFAM Glycoside hydrolase 15-related
GHR20_RS01790	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GHR20_RS01805	COG0586	Pfam SNARE associated Golgi protein
GHR20_RS01810	COG0671	phosphoesterase, PA-phosphatase related
GHR20_RS01825	COG1335	isochorismatase
GHR20_RS01835	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GHR20_RS01890	COG5492	domain, Protein
GHR20_RS01905	COG1309	transcriptional regulator
GHR20_RS01925	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GHR20_RS01985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GHR20_RS02035	COG1335	isochorismatase
GHR20_RS02075	COG2274	protein secretion by the type I secretion system
GHR20_RS02115	COG4221	oxidoreductase activity
GHR20_RS02140	COG2890	protein-(glutamine-N5) methyltransferase activity
GHR20_RS02170	COG1595	DNA-templated transcription, initiation
GHR20_RS02195	COG0667	Aldo Keto reductase
GHR20_RS02215	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GHR20_RS02220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS02225	COG3629	intracellular signal transduction
GHR20_RS02235	COG0657	acetylesterase activity
GHR20_RS02270	COG2124	cytochrome p450
GHR20_RS02290	COG0435	Glutathione S-transferase
GHR20_RS02320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GHR20_RS02325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GHR20_RS02330	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHR20_RS02340	COG2111	Na H antiporter
GHR20_RS02370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GHR20_RS02370	COG1796	DNA polymerase
GHR20_RS02375	COG0546	phosphoglycolate phosphatase activity
GHR20_RS02400	COG1940	carbohydrate kinase activity
GHR20_RS02400	COG1846	Transcriptional regulator
GHR20_RS02420	COG2706	6-phosphogluconolactonase activity
GHR20_RS02450	COG1309	transcriptional regulator
GHR20_RS02460	COG1357	PFAM Pentapeptide repeats (8 copies)
GHR20_RS02480	COG0247	lactate metabolic process
GHR20_RS02485	COG1139	Iron-sulfur cluster binding protein
GHR20_RS02490	COG1556	Lactate utilization protein
GHR20_RS02510	COG1174	glycine betaine transport
GHR20_RS02515	COG0542	response to heat
GHR20_RS02525	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GHR20_RS02630	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GHR20_RS02635	COG0148	phosphopyruvate hydratase activity
GHR20_RS02650	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHR20_RS02655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GHR20_RS02660	COG0515	serine threonine protein kinase
GHR20_RS02660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHR20_RS02665	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS02690	COG1233	COG1233 Phytoene dehydrogenase and related
GHR20_RS02720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS02725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GHR20_RS02740	COG3251	PFAM MbtH domain protein
GHR20_RS02750	COG3340	Belongs to the peptidase S51 family
GHR20_RS02760	COG2197	response regulator
GHR20_RS02785	COG2124	cytochrome p450
GHR20_RS02835	COG0326	Molecular chaperone. Has ATPase activity
GHR20_RS02840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GHR20_RS02845	COG1993	acr, cog1993
GHR20_RS02850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GHR20_RS02855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS02865	COG0659	secondary active sulfate transmembrane transporter activity
GHR20_RS02900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GHR20_RS02905	COG3608	succinylglutamate desuccinylase aspartoacylase
GHR20_RS02905	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GHR20_RS02925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GHR20_RS02925	COG3608	succinylglutamate desuccinylase aspartoacylase
GHR20_RS02940	COG0242	peptide deformylase activity
GHR20_RS02950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHR20_RS02995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GHR20_RS03000	COG0121	glutamine amidotransferase
GHR20_RS03005	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GHR20_RS03010	COG2182	Extracellular solute-binding protein
GHR20_RS03015	COG3360	Dodecin
GHR20_RS03025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS03055	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GHR20_RS03060	COG1053	succinate dehydrogenase
GHR20_RS03110	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GHR20_RS03110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GHR20_RS03130	COG0531	amino acid
GHR20_RS03150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GHR20_RS03200	COG3537	Alpha-1,2-mannosidase
GHR20_RS03220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GHR20_RS03225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GHR20_RS03235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHR20_RS03280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GHR20_RS03295	COG3387	PFAM Glycoside hydrolase 15-related
GHR20_RS03360	COG1595	DNA-templated transcription, initiation
GHR20_RS03425	COG2175	clavaminate synthase activity
GHR20_RS03435	COG0717	Belongs to the dCTP deaminase family
GHR20_RS03450	COG0438	transferase activity, transferring glycosyl groups
GHR20_RS03455	COG0442	prolyl-tRNA aminoacylation
GHR20_RS03465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GHR20_RS03475	COG0535	radical SAM domain protein
GHR20_RS03505	COG1278	Cold shock
GHR20_RS03550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHR20_RS03570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GHR20_RS03585	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GHR20_RS03595	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GHR20_RS03605	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GHR20_RS03610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHR20_RS03625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GHR20_RS03635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GHR20_RS03690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHR20_RS03725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GHR20_RS03725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHR20_RS03745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GHR20_RS03960	COG0582	viral genome integration into host DNA
GHR20_RS03970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS03995	COG0601	transmembrane transport
GHR20_RS04035	COG2308	Evidence 4 Homologs of previously reported genes of
GHR20_RS04035	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GHR20_RS04060	COG1132	(ABC) transporter
GHR20_RS04070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHR20_RS04075	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHR20_RS04085	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GHR20_RS04095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GHR20_RS04100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GHR20_RS04105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GHR20_RS04110	COG0254	rRNA binding
GHR20_RS04120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GHR20_RS04135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GHR20_RS04180	COG1408	metallophosphoesterase
GHR20_RS04205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GHR20_RS04225	COG1509	lysine 2,3-aminomutase activity
GHR20_RS04235	COG0151	Belongs to the GarS family
GHR20_RS04245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS04330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GHR20_RS04335	COG0477	Major facilitator Superfamily
GHR20_RS04345	COG1120	ATPase activity
GHR20_RS04350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHR20_RS04355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHR20_RS04370	COG1535	isochorismatase
GHR20_RS04370	COG3433	isochorismatase activity
GHR20_RS04375	COG1169	isochorismate synthase
GHR20_RS04385	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GHR20_RS04390	COG1535	isochorismatase
GHR20_RS04390	COG3433	isochorismatase activity
GHR20_RS04395	COG1021	2,3-dihydroxybenzoate-AMP ligase
GHR20_RS04400	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS04405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GHR20_RS04520	COG4221	oxidoreductase activity
GHR20_RS04520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS04520	COG3321	synthase
GHR20_RS04530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GHR20_RS04550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GHR20_RS04560	COG0456	acetyltransferase
GHR20_RS04565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GHR20_RS04585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GHR20_RS04590	COG2079	MmgE PrpD family protein
GHR20_RS04595	COG1396	sequence-specific DNA binding
GHR20_RS04595	COG3800	Transcriptional regulator
GHR20_RS04625	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GHR20_RS04645	COG3845	ABC transporter
GHR20_RS04730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GHR20_RS04735	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GHR20_RS04740	COG2080	2 iron, 2 sulfur cluster binding
GHR20_RS04755	COG1132	(ABC) transporter
GHR20_RS04765	COG1024	Enoyl-CoA hydratase
GHR20_RS04775	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHR20_RS04775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GHR20_RS04795	COG0531	amino acid
GHR20_RS04800	COG0668	transmembrane transport
GHR20_RS04810	COG2838	Isocitrate dehydrogenase
GHR20_RS04825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHR20_RS04835	COG2124	cytochrome p450
GHR20_RS04860	COG2197	response regulator
GHR20_RS04870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS04875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS04900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GHR20_RS04905	COG0531	amino acid
GHR20_RS04915	COG0702	epimerase
GHR20_RS04920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GHR20_RS04925	COG2197	response regulator
GHR20_RS04930	COG4585	Histidine kinase
GHR20_RS04935	COG0577	efflux transmembrane transporter activity
GHR20_RS04945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GHR20_RS04950	COG0154	amidase activity
GHR20_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS04980	COG0156	8-amino-7-oxononanoate synthase activity
GHR20_RS04990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHR20_RS05005	COG1132	(ABC) transporter
GHR20_RS05010	COG1132	(ABC) transporter
GHR20_RS05035	COG1509	lysine 2,3-aminomutase activity
GHR20_RS05060	COG0673	inositol 2-dehydrogenase activity
GHR20_RS05070	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHR20_RS05085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS05090	COG3173	Aminoglycoside phosphotransferase
GHR20_RS05165	COG0673	inositol 2-dehydrogenase activity
GHR20_RS05170	COG0673	inositol 2-dehydrogenase activity
GHR20_RS05185	COG1312	Catalyzes the dehydration of D-mannonate
GHR20_RS05190	COG2124	cytochrome p450
GHR20_RS05220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHR20_RS05255	COG2080	2 iron, 2 sulfur cluster binding
GHR20_RS05255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GHR20_RS05280	COG3629	intracellular signal transduction
GHR20_RS05280	COG3903	Transcriptional regulator
GHR20_RS05340	COG0667	Aldo Keto reductase
GHR20_RS05350	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS05355	COG0183	Belongs to the thiolase family
GHR20_RS05360	COG2267	carboxylic ester hydrolase activity
GHR20_RS05385	COG0561	phosphatase activity
GHR20_RS05395	COG0174	glutamine synthetase
GHR20_RS05420	COG3903	Transcriptional regulator
GHR20_RS05420	COG3629	intracellular signal transduction
GHR20_RS05450	COG3629	intracellular signal transduction
GHR20_RS05450	COG3903	Transcriptional regulator
GHR20_RS05475	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GHR20_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS05500	COG1846	Transcriptional regulator
GHR20_RS05555	COG3959	Transketolase, thiamine diphosphate binding domain
GHR20_RS05560	COG3958	Transketolase
GHR20_RS05570	COG0583	DNA-binding transcription factor activity
GHR20_RS05575	COG0156	8-amino-7-oxononanoate synthase activity
GHR20_RS05580	COG1063	alcohol dehydrogenase
GHR20_RS05630	COG1473	amidohydrolase
GHR20_RS05645	COG0842	Transport permease protein
GHR20_RS05650	COG1131	(ABC) transporter
GHR20_RS05700	COG2365	Tyrosine phosphatase family
GHR20_RS05720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GHR20_RS05725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GHR20_RS05740	COG1657	PFAM Prenyltransferase squalene oxidase
GHR20_RS05750	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GHR20_RS05760	COG1562	ergosterol biosynthetic process
GHR20_RS05765	COG1134	teichoic acid transport
GHR20_RS05765	COG1388	LysM domain
GHR20_RS05810	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GHR20_RS05825	COG1024	Enoyl-CoA hydratase
GHR20_RS05845	COG4977	sequence-specific DNA binding
GHR20_RS05850	COG2183	response to ionizing radiation
GHR20_RS05860	COG0488	(ABC) transporter
GHR20_RS05870	COG2936	dipeptidyl-peptidase activity
GHR20_RS05880	COG1113	amino acid transport
GHR20_RS05890	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHR20_RS05890	COG1024	Enoyl-CoA hydratase
GHR20_RS05895	COG0183	Belongs to the thiolase family
GHR20_RS05900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GHR20_RS05905	COG3268	Saccharopine dehydrogenase
GHR20_RS05915	COG1515	deoxyribonuclease V activity
GHR20_RS05940	COG0488	(ABC) transporter
GHR20_RS05945	COG1834	amidinotransferase
GHR20_RS05975	COG1793	dna ligase
GHR20_RS05995	COG0477	Major facilitator Superfamily
GHR20_RS06030	COG3511	phospholipase C
GHR20_RS06055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GHR20_RS06060	COG1486	melibiose metabolic process
GHR20_RS06075	COG0789	Transcriptional regulator
GHR20_RS06080	COG0667	Aldo Keto reductase
GHR20_RS06095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GHR20_RS06110	COG0166	Belongs to the GPI family
GHR20_RS06115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GHR20_RS06120	COG0406	alpha-ribazole phosphatase activity
GHR20_RS06140	COG3467	pyridoxamine 5'-phosphate
GHR20_RS06170	COG2723	6-phospho-beta-galactosidase activity
GHR20_RS06175	COG0395	ABC-type sugar transport system, permease component
GHR20_RS06180	COG1175	transmembrane transport
GHR20_RS06220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GHR20_RS06235	COG4106	trans-aconitate 2-methyltransferase activity
GHR20_RS06260	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
GHR20_RS06260	COG0028	Belongs to the TPP enzyme family
GHR20_RS06290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHR20_RS06310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS06315	COG0006	proline dipeptidase activity
GHR20_RS06330	COG0156	8-amino-7-oxononanoate synthase activity
GHR20_RS06340	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GHR20_RS06345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GHR20_RS06350	COG2423	ornithine cyclodeaminase activity
GHR20_RS06365	COG0569	domain protein
GHR20_RS06365	COG0475	glutathione-regulated potassium exporter activity
GHR20_RS06395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GHR20_RS06410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS06420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS06450	COG3537	Alpha-1,2-mannosidase
GHR20_RS06455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS06460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS06470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS06470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS06505	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GHR20_RS06515	COG0069	glutamate synthase activity
GHR20_RS06530	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS06545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS06550	COG0017	Asparaginyl-tRNA synthetase
GHR20_RS06600	COG2850	peptidyl-arginine hydroxylation
GHR20_RS06625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHR20_RS06630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GHR20_RS06640	COG1846	Transcriptional regulator
GHR20_RS06660	COG0583	DNA-binding transcription factor activity
GHR20_RS06670	COG0656	L-ascorbic acid biosynthetic process
GHR20_RS06695	COG4221	oxidoreductase activity
GHR20_RS06710	COG4106	trans-aconitate 2-methyltransferase activity
GHR20_RS06710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GHR20_RS06715	COG2154	pterin-4-alpha-carbinolamine dehydratase
GHR20_RS06745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GHR20_RS06770	COG0028	Belongs to the TPP enzyme family
GHR20_RS06790	COG0488	(ABC) transporter
GHR20_RS06800	COG1597	lipid kinase activity
GHR20_RS06860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GHR20_RS06885	COG1619	proteins homologs of microcin C7 resistance protein MccF
GHR20_RS06895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHR20_RS06900	COG2362	D-Aminopeptidase
GHR20_RS06905	COG0038	chloride channel
GHR20_RS06915	COG4106	trans-aconitate 2-methyltransferase activity
GHR20_RS06920	COG2172	sigma factor antagonist activity
GHR20_RS06920	COG2208	phosphoserine phosphatase activity
GHR20_RS06920	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS06990	COG1295	ribonuclease BN
GHR20_RS07005	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHR20_RS07015	COG0604	alcohol dehydrogenase
GHR20_RS07020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GHR20_RS07020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GHR20_RS07025	COG2301	Belongs to the HpcH HpaI aldolase family
GHR20_RS07035	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS07040	COG0688	phosphatidylethanolamine metabolic process
GHR20_RS07065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GHR20_RS07080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GHR20_RS07150	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GHR20_RS07155	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GHR20_RS07160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GHR20_RS07170	COG0531	amino acid
GHR20_RS07180	COG0095	Lipoate-protein ligase
GHR20_RS07215	COG0542	response to heat
GHR20_RS07295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GHR20_RS07310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHR20_RS07330	COG0542	response to heat
GHR20_RS07335	COG0405	Gamma-glutamyltransferase
GHR20_RS07360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GHR20_RS07365	COG0667	Aldo Keto reductase
GHR20_RS07380	COG4221	oxidoreductase activity
GHR20_RS07455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS07460	COG0017	Asparaginyl-tRNA synthetase
GHR20_RS07465	COG0069	glutamate synthase activity
GHR20_RS07470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GHR20_RS07485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GHR20_RS07495	COG1940	carbohydrate kinase activity
GHR20_RS07515	COG2188	Transcriptional regulator
GHR20_RS07520	COG0673	inositol 2-dehydrogenase activity
GHR20_RS07555	COG4266	Belongs to the allantoicase family
GHR20_RS07565	COG1414	Transcriptional regulator
GHR20_RS07580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GHR20_RS07585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GHR20_RS07615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GHR20_RS07625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS07630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS07635	COG0069	glutamate synthase activity
GHR20_RS07640	COG0017	Asparaginyl-tRNA synthetase
GHR20_RS07660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GHR20_RS07665	COG3251	PFAM MbtH domain protein
GHR20_RS07690	COG0384	phenazine biosynthesis protein PhzF
GHR20_RS07705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GHR20_RS07730	COG4264	IucA IucC family
GHR20_RS07750	COG1733	regulation of RNA biosynthetic process
GHR20_RS07775	COG2233	PERMEase
GHR20_RS07790	COG2351	hydroxyisourate hydrolase activity
GHR20_RS07810	COG3622	Belongs to the hyi family
GHR20_RS07815	COG2084	Dehydrogenase
GHR20_RS07820	COG0753	catalase activity
GHR20_RS07835	COG3960	tartronate-semialdehyde synthase activity
GHR20_RS07845	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS07850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GHR20_RS07855	COG2197	response regulator
GHR20_RS07875	COG1653	transport
GHR20_RS07900	COG0726	polysaccharide deacetylase
GHR20_RS07920	COG2252	PERMEase
GHR20_RS07925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GHR20_RS07955	COG1802	Transcriptional regulator
GHR20_RS07970	COG0028	Belongs to the TPP enzyme family
GHR20_RS07995	COG2267	carboxylic ester hydrolase activity
GHR20_RS08010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GHR20_RS08030	COG1162	GTPase activity
GHR20_RS08040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GHR20_RS08050	COG0473	3-isopropylmalate dehydrogenase activity
GHR20_RS08050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GHR20_RS08065	COG0583	DNA-binding transcription factor activity
GHR20_RS08070	COG2814	Major facilitator Superfamily
GHR20_RS08075	COG1942	4-Oxalocrotonate Tautomerase
GHR20_RS08090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GHR20_RS08095	COG0277	FAD linked oxidase domain protein
GHR20_RS08115	COG2040	homocysteine
GHR20_RS08130	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GHR20_RS08175	COG0175	sulfate reduction
GHR20_RS08180	COG0529	Catalyzes the synthesis of activated sulfate
GHR20_RS08205	COG1116	anion transmembrane transporter activity
GHR20_RS08205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GHR20_RS08225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GHR20_RS08285	COG3173	Aminoglycoside phosphotransferase
GHR20_RS08295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHR20_RS08355	COG1174	glycine betaine transport
GHR20_RS08360	COG1174	glycine betaine transport
GHR20_RS08370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GHR20_RS08375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GHR20_RS08405	COG1881	PFAM PEBP family protein
GHR20_RS08410	COG2326	polyphosphate kinase activity
GHR20_RS08415	COG0723	plastoquinol--plastocyanin reductase activity
GHR20_RS08415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHR20_RS08430	COG4152	abc transporter atp-binding protein
GHR20_RS08465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHR20_RS08485	COG3220	belongs to the UPF0276 family
GHR20_RS08500	COG3253	May function as heme-dependent peroxidase
GHR20_RS08505	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GHR20_RS08510	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHR20_RS08520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GHR20_RS08535	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GHR20_RS08540	COG0183	Belongs to the thiolase family
GHR20_RS08545	COG1024	Enoyl-CoA hydratase
GHR20_RS08545	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHR20_RS08560	COG0531	amino acid
GHR20_RS08565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GHR20_RS08575	COG4214	carbohydrate transport
GHR20_RS08585	COG4213	ABC transporter substrate-binding protein
GHR20_RS08590	COG1940	carbohydrate kinase activity
GHR20_RS08595	COG0395	ABC-type sugar transport system, permease component
GHR20_RS08600	COG1175	transmembrane transport
GHR20_RS08605	COG1653	transport
GHR20_RS08640	COG4195	phage-related replication protein
GHR20_RS08655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GHR20_RS08660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GHR20_RS08675	COG1522	sequence-specific DNA binding
GHR20_RS08680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GHR20_RS08695	COG3634	alkyl hydroperoxide reductase activity
GHR20_RS08705	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS08730	COG0251	oxidation-reduction process
GHR20_RS08740	COG2264	protein methyltransferase activity
GHR20_RS08755	COG3629	intracellular signal transduction
GHR20_RS08810	COG1472	Belongs to the glycosyl hydrolase 3 family
GHR20_RS08815	COG0395	ABC-type sugar transport system, permease component
GHR20_RS08820	COG1175	transmembrane transport
GHR20_RS08825	COG2182	Extracellular solute-binding protein
GHR20_RS08830	COG2188	Transcriptional regulator
GHR20_RS08875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GHR20_RS08885	COG0477	Major facilitator Superfamily
GHR20_RS08900	COG0477	Major facilitator Superfamily
GHR20_RS08905	COG0477	Major facilitator Superfamily
GHR20_RS08910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHR20_RS08925	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS08940	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS08950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHR20_RS08975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHR20_RS08980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GHR20_RS08985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHR20_RS08995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GHR20_RS09000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GHR20_RS09005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GHR20_RS09010	COG2814	Major facilitator Superfamily
GHR20_RS09030	COG3629	intracellular signal transduction
GHR20_RS09035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHR20_RS09100	COG1024	Enoyl-CoA hydratase
GHR20_RS09110	COG0531	amino acid
GHR20_RS09115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GHR20_RS09120	COG2235	arginine
GHR20_RS09135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GHR20_RS09145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS09165	COG1799	cell septum assembly
GHR20_RS09235	COG1846	Transcriptional regulator
GHR20_RS09290	COG3629	intracellular signal transduction
GHR20_RS09290	COG3903	Transcriptional regulator
GHR20_RS09335	COG0438	transferase activity, transferring glycosyl groups
GHR20_RS09340	COG2197	response regulator
GHR20_RS09350	COG1136	(ABC) transporter
GHR20_RS09360	COG2197	response regulator
GHR20_RS09380	COG3251	PFAM MbtH domain protein
GHR20_RS09390	COG2175	clavaminate synthase activity
GHR20_RS09420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GHR20_RS09425	COG0531	amino acid
GHR20_RS09430	COG0569	domain protein
GHR20_RS09465	COG0756	dUTP diphosphatase activity
GHR20_RS09490	COG2205	protein histidine kinase activity
GHR20_RS09495	COG0745	RESPONSE REGULATOR receiver
GHR20_RS09505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GHR20_RS09540	COG1435	thymidine kinase activity
GHR20_RS09560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHR20_RS09565	COG1802	Transcriptional regulator
GHR20_RS09580	COG0612	Peptidase, M16
GHR20_RS09585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GHR20_RS09595	COG0372	Belongs to the citrate synthase family
GHR20_RS09620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GHR20_RS09630	COG4565	transcriptional regulatory protein
GHR20_RS09635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GHR20_RS09645	COG2197	response regulator
GHR20_RS09665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHR20_RS09670	COG0187	DNA topoisomerase II activity
GHR20_RS09685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GHR20_RS09690	COG2186	Transcriptional regulator
GHR20_RS09725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GHR20_RS09735	COG0588	phosphoglycerate mutase activity
GHR20_RS09755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GHR20_RS09760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GHR20_RS09765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GHR20_RS09800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GHR20_RS09810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GHR20_RS09815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GHR20_RS09825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GHR20_RS09845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GHR20_RS09885	COG2205	protein histidine kinase activity
GHR20_RS09890	COG0745	RESPONSE REGULATOR receiver
GHR20_RS09895	COG1126	abc transporter atp-binding protein
GHR20_RS09900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHR20_RS09905	COG0765	amino acid transport
GHR20_RS09910	COG0765	amino acid transport
GHR20_RS09925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHR20_RS09975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GHR20_RS09985	COG0783	Belongs to the Dps family
GHR20_RS09990	COG1396	sequence-specific DNA binding
GHR20_RS09995	COG1058	Belongs to the CinA family
GHR20_RS09995	COG1546	Belongs to the CinA family
GHR20_RS10005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GHR20_RS10015	COG1674	ftsk spoiiie
GHR20_RS10025	COG0784	Response regulator, receiver
GHR20_RS10025	COG2205	protein histidine kinase activity
GHR20_RS10035	COG2208	phosphoserine phosphatase activity
GHR20_RS10035	COG2770	Histidine kinase
GHR20_RS10065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GHR20_RS10070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHR20_RS10075	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GHR20_RS10095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GHR20_RS10100	COG0612	Peptidase, M16
GHR20_RS10105	COG1185	polyribonucleotide nucleotidyltransferase activity
GHR20_RS10110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GHR20_RS10125	COG1674	ftsk spoiiie
GHR20_RS10140	COG1404	Belongs to the peptidase S8 family
GHR20_RS10160	COG3266	domain, Protein
GHR20_RS10175	COG0455	bacterial-type flagellum organization
GHR20_RS10190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GHR20_RS10195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GHR20_RS10205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GHR20_RS10220	COG0779	Required for maturation of 30S ribosomal subunits
GHR20_RS10240	COG0583	DNA-binding transcription factor activity
GHR20_RS10245	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS10250	COG0442	prolyl-tRNA aminoacylation
GHR20_RS10255	COG1247	-acetyltransferase
GHR20_RS10295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GHR20_RS10300	COG0750	zinc metalloprotease
GHR20_RS10305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GHR20_RS10330	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS10365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHR20_RS10370	COG1177	transmembrane transport
GHR20_RS10380	COG3842	ATPase activity
GHR20_RS10390	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS10405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GHR20_RS10410	COG0584	glycerophosphoryl diester phosphodiesterase
GHR20_RS10420	COG5002	protein histidine kinase activity
GHR20_RS10420	COG0784	Response regulator, receiver
GHR20_RS10420	COG2198	Histidine kinase
GHR20_RS10430	COG2172	sigma factor antagonist activity
GHR20_RS10435	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS10440	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS10460	COG1653	transport
GHR20_RS10465	COG1175	transmembrane transport
GHR20_RS10470	COG0395	ABC-type sugar transport system, permease component
GHR20_RS10480	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS10490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GHR20_RS10495	COG4181	ATPase activity
GHR20_RS10515	COG3842	ATPase activity
GHR20_RS10520	COG4208	sulfate ABC transporter
GHR20_RS10530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GHR20_RS10540	COG0575	Belongs to the CDS family
GHR20_RS10545	COG0233	cytoplasmic translational termination
GHR20_RS10550	COG0528	UMP kinase activity
GHR20_RS10555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GHR20_RS10560	COG0052	Belongs to the universal ribosomal protein uS2 family
GHR20_RS10565	COG4942	peptidase
GHR20_RS10575	COG1191	sigma factor activity
GHR20_RS10590	COG0792	nuclease activity
GHR20_RS10600	COG0494	nUDIX hydrolase
GHR20_RS10610	COG0681	Belongs to the peptidase S26 family
GHR20_RS10625	COG0335	large ribosomal subunit rRNA binding
GHR20_RS10630	COG0336	Belongs to the RNA methyltransferase TrmD family
GHR20_RS10635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GHR20_RS10640	COG1837	Belongs to the UPF0109 family
GHR20_RS10645	COG0228	four-way junction DNA binding
GHR20_RS10670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GHR20_RS10710	COG0477	Major facilitator Superfamily
GHR20_RS10730	COG1254	Belongs to the acylphosphatase family
GHR20_RS10740	COG0655	NAD(P)H dehydrogenase (quinone) activity
GHR20_RS10745	COG1733	regulation of RNA biosynthetic process
GHR20_RS10750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GHR20_RS10755	COG0571	ribonuclease III activity
GHR20_RS10760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GHR20_RS10775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GHR20_RS10780	COG0742	ribosomal rna small subunit methyltransferase
GHR20_RS10790	COG0326	Molecular chaperone. Has ATPase activity
GHR20_RS10800	COG1461	Dihydroxyacetone kinase
GHR20_RS10805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GHR20_RS10820	COG0351	phosphomethylpyrimidine kinase
GHR20_RS10840	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHR20_RS10845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GHR20_RS10855	COG1920	GTP binding
GHR20_RS10865	COG0776	regulation of translation
GHR20_RS10875	COG0066	3-isopropylmalate dehydratase activity
GHR20_RS10880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GHR20_RS10885	COG1414	Transcriptional regulator
GHR20_RS10935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GHR20_RS10940	COG0179	Fumarylacetoacetate (FAA) hydrolase
GHR20_RS10950	COG5002	protein histidine kinase activity
GHR20_RS10975	COG2018	Roadblock/LC7 domain
GHR20_RS10995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHR20_RS11000	COG2353	YceI-like domain
GHR20_RS11015	COG1472	Belongs to the glycosyl hydrolase 3 family
GHR20_RS11030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GHR20_RS11035	COG0477	Major facilitator Superfamily
GHR20_RS11050	COG2957	Belongs to the agmatine deiminase family
GHR20_RS11055	COG0804	urea catabolic process
GHR20_RS11065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GHR20_RS11070	COG0473	3-isopropylmalate dehydrogenase activity
GHR20_RS11085	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS11095	COG3835	regulator
GHR20_RS11105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GHR20_RS11110	COG0440	acetolactate synthase activity
GHR20_RS11120	COG3300	MHYT domain
GHR20_RS11120	COG5001	Diguanylate cyclase
GHR20_RS11130	COG0667	Aldo Keto reductase
GHR20_RS11135	COG2133	pyrroloquinoline quinone binding
GHR20_RS11155	COG2409	Drug exporters of the RND superfamily
GHR20_RS11160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GHR20_RS11170	COG0154	amidase activity
GHR20_RS11175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GHR20_RS11200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GHR20_RS11210	COG4221	oxidoreductase activity
GHR20_RS11215	COG1611	Belongs to the LOG family
GHR20_RS11230	COG0482	sulfurtransferase activity
GHR20_RS11270	COG0583	DNA-binding transcription factor activity
GHR20_RS11295	COG0308	aminopeptidase N
GHR20_RS11310	COG0601	transmembrane transport
GHR20_RS11320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHR20_RS11340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GHR20_RS11345	COG0509	glycine decarboxylation via glycine cleavage system
GHR20_RS11350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GHR20_RS11355	COG1760	l-serine dehydratase
GHR20_RS11400	COG1024	Enoyl-CoA hydratase
GHR20_RS11410	COG1376	ErfK ybiS ycfS ynhG family protein
GHR20_RS11430	COG1215	transferase activity, transferring glycosyl groups
GHR20_RS11450	COG1132	(ABC) transporter
GHR20_RS11455	COG1132	(ABC) transporter
GHR20_RS11460	COG1131	(ABC) transporter
GHR20_RS11470	COG4585	Histidine kinase
GHR20_RS11495	COG0058	SHG alpha-glucan phosphorylase activity
GHR20_RS11500	COG0366	Alpha amylase catalytic
GHR20_RS11510	COG3281	Trehalose synthase
GHR20_RS11540	COG0477	Major facilitator Superfamily
GHR20_RS11550	COG1301	dicarboxylic acid transport
GHR20_RS11555	COG3290	protein histidine kinase activity
GHR20_RS11560	COG4565	transcriptional regulatory protein
GHR20_RS11570	COG1175	transmembrane transport
GHR20_RS11575	COG0395	ABC-type sugar transport system, permease component
GHR20_RS11585	COG0205	6-phosphofructokinase activity
GHR20_RS11590	COG0280	phosphate acetyltransferase
GHR20_RS11590	COG0857	belongs to the CobB CobQ family
GHR20_RS11595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GHR20_RS11630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GHR20_RS11630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GHR20_RS11695	COG0183	Belongs to the thiolase family
GHR20_RS11750	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GHR20_RS11765	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHR20_RS11805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GHR20_RS11810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GHR20_RS11815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GHR20_RS11820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GHR20_RS11825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GHR20_RS11830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GHR20_RS11835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GHR20_RS11850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHR20_RS11855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GHR20_RS11860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GHR20_RS11870	COG2890	protein-(glutamine-N5) methyltransferase activity
GHR20_RS11875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GHR20_RS11880	COG0254	rRNA binding
GHR20_RS11895	COG0083	homoserine kinase activity
GHR20_RS11900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GHR20_RS11905	COG0460	homoserine dehydrogenase
GHR20_RS11910	COG0019	diaminopimelate decarboxylase activity
GHR20_RS11915	COG0018	arginyl-trna synthetase
GHR20_RS11975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GHR20_RS11980	COG1720	tRNA m6t6A37 methyltransferase activity
GHR20_RS11985	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHR20_RS12000	COG0626	cystathionine gamma-synthase activity
GHR20_RS12010	COG1720	tRNA m6t6A37 methyltransferase activity
GHR20_RS12040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GHR20_RS12045	COG3629	intracellular signal transduction
GHR20_RS12045	COG3903	Transcriptional regulator
GHR20_RS12060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GHR20_RS12070	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GHR20_RS12075	COG3285	dna ligase
GHR20_RS12075	COG1793	dna ligase
GHR20_RS12080	COG2409	Drug exporters of the RND superfamily
GHR20_RS12090	COG2197	response regulator
GHR20_RS12110	COG2205	protein histidine kinase activity
GHR20_RS12120	COG0768	penicillin binding
GHR20_RS12190	COG5002	protein histidine kinase activity
GHR20_RS12210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GHR20_RS12220	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GHR20_RS12225	COG0745	RESPONSE REGULATOR receiver
GHR20_RS12230	COG2205	protein histidine kinase activity
GHR20_RS12235	COG0567	Dehydrogenase, E1 component
GHR20_RS12235	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHR20_RS12255	COG0604	alcohol dehydrogenase
GHR20_RS12260	COG0281	malic enzyme
GHR20_RS12275	COG1126	abc transporter atp-binding protein
GHR20_RS12280	COG4106	trans-aconitate 2-methyltransferase activity
GHR20_RS12300	COG0582	viral genome integration into host DNA
GHR20_RS12430	COG1335	isochorismatase
GHR20_RS12445	COG4249	Peptidase C14 caspase catalytic subunit p20
GHR20_RS12445	COG2319	Wd-40 repeat
GHR20_RS12475	COG0142	geranyltranstransferase activity
GHR20_RS12480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GHR20_RS12485	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GHR20_RS12500	COG2172	sigma factor antagonist activity
GHR20_RS12515	COG1597	lipid kinase activity
GHR20_RS12530	COG0363	glucosamine-6-phosphate deaminase activity
GHR20_RS12535	COG2188	Transcriptional regulator
GHR20_RS12565	COG4977	sequence-specific DNA binding
GHR20_RS12570	COG2124	cytochrome p450
GHR20_RS12580	COG0242	peptide deformylase activity
GHR20_RS12590	COG5662	AntiSigma factor
GHR20_RS12595	COG1595	DNA-templated transcription, initiation
GHR20_RS12605	COG2135	peptidase activity
GHR20_RS12635	COG0483	inositol monophosphate 1-phosphatase activity
GHR20_RS12645	COG0753	catalase activity
GHR20_RS12670	COG1615	UPF0182 protein
GHR20_RS12680	COG3480	Lon protease (S16) C-terminal proteolytic domain
GHR20_RS12730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GHR20_RS12765	COG2816	NAD+ diphosphatase activity
GHR20_RS12805	COG1846	Transcriptional regulator
GHR20_RS12830	COG0438	transferase activity, transferring glycosyl groups
GHR20_RS12835	COG4172	Belongs to the ABC transporter superfamily
GHR20_RS12840	COG0601	transmembrane transport
GHR20_RS12845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHR20_RS12890	COG0513	Belongs to the DEAD box helicase family
GHR20_RS12900	COG1432	Conserved Protein
GHR20_RS12905	COG2095	MarC family integral membrane protein
GHR20_RS12920	COG2814	Major facilitator Superfamily
GHR20_RS12930	COG0598	Magnesium transport protein CorA
GHR20_RS12965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GHR20_RS12970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHR20_RS12980	COG1595	DNA-templated transcription, initiation
GHR20_RS12995	COG1024	Enoyl-CoA hydratase
GHR20_RS13000	COG0519	Catalyzes the synthesis of GMP from XMP
GHR20_RS13010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GHR20_RS13015	COG1611	Belongs to the LOG family
GHR20_RS13020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHR20_RS13055	COG2197	response regulator
GHR20_RS13060	COG4585	Histidine kinase
GHR20_RS13070	COG1131	(ABC) transporter
GHR20_RS13085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GHR20_RS13100	COG4608	Belongs to the ABC transporter superfamily
GHR20_RS13105	COG0444	Belongs to the ABC transporter superfamily
GHR20_RS13110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHR20_RS13115	COG0601	transmembrane transport
GHR20_RS13120	COG4166	transmembrane transport
GHR20_RS13125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHR20_RS13130	COG0747	negative chemotaxis
GHR20_RS13135	COG0601	transmembrane transport
GHR20_RS13140	COG0444	Belongs to the ABC transporter superfamily
GHR20_RS13145	COG4608	Belongs to the ABC transporter superfamily
GHR20_RS13150	COG0346	lactoylglutathione lyase activity
GHR20_RS13160	COG4608	Belongs to the ABC transporter superfamily
GHR20_RS13170	COG0601	transmembrane transport
GHR20_RS13175	COG0747	negative chemotaxis
GHR20_RS13185	COG1217	gtp-binding protein TYPA
GHR20_RS13205	COG1053	succinate dehydrogenase
GHR20_RS13270	COG0012	GTP binding
GHR20_RS13285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GHR20_RS13290	COG1570	exodeoxyribonuclease VII activity
GHR20_RS13295	COG1722	exodeoxyribonuclease VII activity
GHR20_RS13300	COG0778	Nitroreductase
GHR20_RS13325	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GHR20_RS13325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GHR20_RS13330	COG0114	fumarate hydratase activity
GHR20_RS13345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GHR20_RS13355	COG1136	(ABC) transporter
GHR20_RS13370	COG0450	alkyl hydroperoxide reductase
GHR20_RS13375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GHR20_RS13390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GHR20_RS13395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GHR20_RS13410	COG2885	chlorophyll binding
GHR20_RS13430	COG2197	response regulator
GHR20_RS13435	COG3920	Histidine kinase
GHR20_RS13465	COG2894	cell division
GHR20_RS13525	COG0251	oxidation-reduction process
GHR20_RS13530	COG1414	Transcriptional regulator
GHR20_RS13545	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GHR20_RS13555	COG0436	Aminotransferase
GHR20_RS13565	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GHR20_RS13575	COG1309	transcriptional regulator
GHR20_RS13585	COG1331	Highly conserved protein containing a thioredoxin domain
GHR20_RS13595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHR20_RS13605	COG0667	Aldo Keto reductase
GHR20_RS13640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GHR20_RS13640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GHR20_RS13665	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GHR20_RS13690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHR20_RS13700	COG0367	asparagine synthase
GHR20_RS13710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GHR20_RS13715	COG2197	response regulator
GHR20_RS13750	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GHR20_RS13760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHR20_RS13770	COG0477	Major facilitator Superfamily
GHR20_RS13775	COG1819	glycosyl
GHR20_RS13795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHR20_RS13825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GHR20_RS13835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHR20_RS13840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GHR20_RS13850	COG1595	DNA-templated transcription, initiation
GHR20_RS13870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GHR20_RS13875	COG1064	alcohol dehydrogenase
GHR20_RS13885	COG1136	(ABC) transporter
GHR20_RS13915	COG2986	histidine ammonia-lyase
GHR20_RS13925	COG1024	Enoyl-CoA hydratase
GHR20_RS13935	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GHR20_RS13945	COG2267	carboxylic ester hydrolase activity
GHR20_RS13960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHR20_RS13970	COG0424	maF-like protein
GHR20_RS13980	COG4770	biotin carboxylase activity
GHR20_RS14005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GHR20_RS14015	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GHR20_RS14020	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS14025	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS14040	COG1595	DNA-templated transcription, initiation
GHR20_RS14045	COG0745	RESPONSE REGULATOR receiver
GHR20_RS14050	COG2205	protein histidine kinase activity
GHR20_RS14075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GHR20_RS14085	COG0583	DNA-binding transcription factor activity
GHR20_RS14090	COG2814	Major facilitator Superfamily
GHR20_RS14125	COG1079	Belongs to the binding-protein-dependent transport system permease family
GHR20_RS14130	COG4603	Belongs to the binding-protein-dependent transport system permease family
GHR20_RS14135	COG3845	ABC transporter
GHR20_RS14140	COG1744	ABC transporter substrate-binding protein PnrA-like
GHR20_RS14145	COG1473	amidohydrolase
GHR20_RS14145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GHR20_RS14155	COG2089	acid synthase
GHR20_RS14170	COG1216	Glycosyl transferase, family 2
GHR20_RS14180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GHR20_RS14215	COG1595	DNA-templated transcription, initiation
GHR20_RS14225	COG2197	response regulator
GHR20_RS14265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GHR20_RS14275	COG2009	succinate dehydrogenase
GHR20_RS14285	COG1053	succinate dehydrogenase
GHR20_RS14300	COG1309	transcriptional regulator
GHR20_RS14315	COG1686	Belongs to the peptidase S11 family
GHR20_RS14320	COG1295	ribonuclease BN
GHR20_RS14335	COG0180	Tryptophanyl-tRNA synthetase
GHR20_RS14340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GHR20_RS14345	COG0754	glutathionylspermidine amidase activity
GHR20_RS14365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GHR20_RS14370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GHR20_RS14385	COG4176	ABC-type proline glycine betaine transport system permease component
GHR20_RS14390	COG4175	Glycine betaine
GHR20_RS14390	COG0517	IMP dehydrogenase activity
GHR20_RS14410	COG0477	Major facilitator Superfamily
GHR20_RS14415	COG0039	L-malate dehydrogenase activity
GHR20_RS14430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GHR20_RS14455	COG0138	bifunctional purine biosynthesis protein purh
GHR20_RS14485	COG0045	succinate-CoA ligase (ADP-forming) activity
GHR20_RS14490	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GHR20_RS14500	COG0714	Associated with various cellular activities
GHR20_RS14515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GHR20_RS14515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GHR20_RS14520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GHR20_RS14550	COG2197	response regulator
GHR20_RS14595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GHR20_RS14595	COG0519	Catalyzes the synthesis of GMP from XMP
GHR20_RS14610	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS14615	COG0515	serine threonine protein kinase
GHR20_RS14630	COG2815	serine threonine protein kinase
GHR20_RS14630	COG0515	serine threonine protein kinase
GHR20_RS14635	COG0515	serine threonine protein kinase
GHR20_RS14640	COG2815	serine threonine protein kinase
GHR20_RS14640	COG0515	serine threonine protein kinase
GHR20_RS14650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GHR20_RS14660	COG0516	GMP reductase activity
GHR20_RS14670	COG1595	DNA-templated transcription, initiation
GHR20_RS14685	COG0583	DNA-binding transcription factor activity
GHR20_RS14695	COG4221	oxidoreductase activity
GHR20_RS14700	COG0459	protein refolding
GHR20_RS14710	COG0726	polysaccharide deacetylase
GHR20_RS14715	COG0726	polysaccharide deacetylase
GHR20_RS14740	COG1175	transmembrane transport
GHR20_RS14750	COG1472	Belongs to the glycosyl hydrolase 3 family
GHR20_RS14765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GHR20_RS14785	COG0802	atpase or kinase
GHR20_RS14795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GHR20_RS14805	COG0736	holo-[acyl-carrier-protein] synthase activity
GHR20_RS14810	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS14815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GHR20_RS14825	COG1072	(Pantothenic acid kinase))
GHR20_RS14835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GHR20_RS14840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GHR20_RS14845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GHR20_RS14855	COG0101	tRNA pseudouridine synthase activity
GHR20_RS14860	COG0203	ribosomal protein L17
GHR20_RS14865	COG0202	RNA polymerase activity
GHR20_RS14870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GHR20_RS14875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GHR20_RS14880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GHR20_RS14885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GHR20_RS14905	COG0200	Binds to the 23S rRNA
GHR20_RS14910	COG1841	ribosomal large subunit assembly
GHR20_RS14915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GHR20_RS14920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GHR20_RS14925	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GHR20_RS14930	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GHR20_RS14940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GHR20_RS14945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GHR20_RS14950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GHR20_RS14955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GHR20_RS14960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GHR20_RS14965	COG0255	Belongs to the universal ribosomal protein uL29 family
GHR20_RS14970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GHR20_RS14975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GHR20_RS14980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GHR20_RS14985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GHR20_RS14990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GHR20_RS14995	COG0089	rRNA binding
GHR20_RS15000	COG0088	Forms part of the polypeptide exit tunnel
GHR20_RS15005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GHR20_RS15010	COG0051	transcription antitermination factor activity, RNA binding
GHR20_RS15060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GHR20_RS15065	COG0049	tRNA binding
GHR20_RS15070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GHR20_RS15105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GHR20_RS15110	COG0085	RNA polymerase activity
GHR20_RS15115	COG0222	ribosome binding
GHR20_RS15120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GHR20_RS15130	COG0081	regulation of translation
GHR20_RS15140	COG0250	Participates in transcription elongation, termination and antitermination
GHR20_RS15155	COG0436	Aminotransferase
GHR20_RS15160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GHR20_RS15165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GHR20_RS15185	COG2030	dehydratase
GHR20_RS15190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GHR20_RS15210	COG0702	epimerase
GHR20_RS15230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHR20_RS15295	COG0270	DNA (cytosine-5-)-methyltransferase activity
GHR20_RS15330	COG1666	GTP binding
GHR20_RS15335	COG2261	transglycosylase associated protein
GHR20_RS15350	COG0501	Belongs to the peptidase M48B family
GHR20_RS15355	COG1007	ATP synthesis coupled electron transport
GHR20_RS15370	COG0713	ATP synthesis coupled electron transport
GHR20_RS15375	COG0839	Belongs to the complex I subunit 6 family
GHR20_RS15380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHR20_RS15385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GHR20_RS15390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHR20_RS15395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHR20_RS15400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHR20_RS15415	COG2197	response regulator
GHR20_RS15420	COG0674	pyruvate-flavodoxin oxidoreductase activity
GHR20_RS15420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GHR20_RS15425	COG1013	pyruvate-flavodoxin oxidoreductase activity
GHR20_RS15430	COG0702	epimerase
GHR20_RS15480	COG0142	geranyltranstransferase activity
GHR20_RS15485	COG3953	SLT domain
GHR20_RS15485	COG5412	phage tail tape measure protein
GHR20_RS15490	COG0561	phosphatase activity
GHR20_RS15495	COG0492	ferredoxin-NADP+ reductase activity
GHR20_RS15515	COG0514	ATP-dependent DNA helicase (RecQ)
GHR20_RS15525	COG1007	ATP synthesis coupled electron transport
GHR20_RS15535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GHR20_RS15540	COG0713	ATP synthesis coupled electron transport
GHR20_RS15545	COG0839	Belongs to the complex I subunit 6 family
GHR20_RS15550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHR20_RS15555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GHR20_RS15560	COG1034	ATP synthesis coupled electron transport
GHR20_RS15575	COG0649	NAD binding
GHR20_RS15580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHR20_RS15585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHR20_RS15600	COG0242	peptide deformylase activity
GHR20_RS15620	COG2226	methyltransferase
GHR20_RS15630	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GHR20_RS15650	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GHR20_RS15655	COG1278	Cold shock
GHR20_RS15660	COG2226	methyltransferase
GHR20_RS15670	COG3629	intracellular signal transduction
GHR20_RS15670	COG3903	Transcriptional regulator
GHR20_RS15675	COG3629	intracellular signal transduction
GHR20_RS15740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GHR20_RS15745	COG1309	transcriptional regulator
GHR20_RS15760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GHR20_RS15770	COG0163	prenyltransferase activity
GHR20_RS15780	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GHR20_RS15815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GHR20_RS15820	COG1333	cytochrome c biogenesis protein
GHR20_RS15840	COG0406	alpha-ribazole phosphatase activity
GHR20_RS15845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GHR20_RS15890	COG1191	sigma factor activity
GHR20_RS15920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GHR20_RS15920	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GHR20_RS15925	COG2205	protein histidine kinase activity
GHR20_RS15940	COG1742	UPF0060 membrane protein
GHR20_RS15965	COG1690	Belongs to the RtcB family
GHR20_RS15985	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GHR20_RS15990	COG0018	arginyl-trna synthetase
GHR20_RS16020	COG2910	NAD(P)H-binding
GHR20_RS16025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS16030	COG0113	porphobilinogen synthase activity
GHR20_RS16075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GHR20_RS16075	COG1648	precorrin-2 dehydrogenase activity
GHR20_RS16080	COG0181	hydroxymethylbilane synthase activity
GHR20_RS16085	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GHR20_RS16090	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GHR20_RS16140	COG0123	including yeast histone deacetylase and acetoin utilization protein
GHR20_RS16145	COG0738	Major facilitator superfamily
GHR20_RS16180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GHR20_RS16200	COG4991	sh3 domain protein
GHR20_RS16210	COG0129	dihydroxy-acid dehydratase activity
GHR20_RS16215	COG1309	transcriptional regulator
GHR20_RS16220	COG1082	Xylose isomerase domain protein TIM barrel
GHR20_RS16225	COG0248	Ppx GppA phosphatase
GHR20_RS16245	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GHR20_RS16255	COG1194	a g-specific adenine glycosylase
GHR20_RS16260	COG1595	DNA-templated transcription, initiation
GHR20_RS16270	COG0745	RESPONSE REGULATOR receiver
GHR20_RS16275	COG2205	protein histidine kinase activity
GHR20_RS16290	COG0739	heme binding
GHR20_RS16325	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GHR20_RS16345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GHR20_RS16355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GHR20_RS16360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GHR20_RS16375	COG2197	response regulator
GHR20_RS16390	COG0649	NAD binding
GHR20_RS16420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GHR20_RS16435	COG0302	gtp cyclohydrolase
GHR20_RS16450	COG0037	tRNA processing
GHR20_RS16460	COG2027	D-alanyl-D-alanine carboxypeptidase
GHR20_RS16465	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GHR20_RS16480	COG0393	Putative heavy-metal-binding
GHR20_RS16485	COG0789	Transcriptional regulator
GHR20_RS16490	COG0076	glutamate decarboxylase activity
GHR20_RS16495	COG2318	DinB family
GHR20_RS16500	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS16540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GHR20_RS16540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GHR20_RS16555	COG0475	glutathione-regulated potassium exporter activity
GHR20_RS16580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GHR20_RS16585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GHR20_RS16585	COG1754	DNA topoisomerase type I activity
GHR20_RS16605	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GHR20_RS16610	COG2172	sigma factor antagonist activity
GHR20_RS16615	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS16680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GHR20_RS16695	COG2267	carboxylic ester hydrolase activity
GHR20_RS16730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHR20_RS16740	COG0251	oxidation-reduction process
GHR20_RS16755	COG0003	Pfam Anion-transporting ATPase
GHR20_RS16775	COG1610	YqeY-like protein
GHR20_RS16845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GHR20_RS16865	COG0297	glycogen (starch) synthase activity
GHR20_RS16870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GHR20_RS16910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GHR20_RS16925	COG1937	Protein conserved in bacteria
GHR20_RS16955	COG1595	DNA-templated transcription, initiation
GHR20_RS16975	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GHR20_RS16980	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GHR20_RS16995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GHR20_RS17000	COG1802	Transcriptional regulator
GHR20_RS17010	COG0737	Belongs to the 5'-nucleotidase family
GHR20_RS17015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GHR20_RS17040	COG2197	response regulator
GHR20_RS17045	COG4585	Histidine kinase
GHR20_RS17055	COG3844	kynureninase activity
GHR20_RS17060	COG3483	tryptophan 2,3-dioxygenase activity
GHR20_RS17070	COG0477	Major facilitator Superfamily
GHR20_RS17080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GHR20_RS17095	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GHR20_RS17125	COG0542	response to heat
GHR20_RS17160	COG4213	ABC transporter substrate-binding protein
GHR20_RS17165	COG0789	Transcriptional regulator
GHR20_RS17170	COG0484	heat shock protein binding
GHR20_RS17175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GHR20_RS17180	COG0443	Heat shock 70 kDa protein
GHR20_RS17185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHR20_RS17190	COG2181	nitrate reductase activity
GHR20_RS17190	COG0247	lactate metabolic process
GHR20_RS17205	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GHR20_RS17210	COG0717	Belongs to the dCTP deaminase family
GHR20_RS17360	COG1595	DNA-templated transcription, initiation
GHR20_RS17420	COG1278	Cold shock
GHR20_RS17465	COG3903	Transcriptional regulator
GHR20_RS17465	COG3629	intracellular signal transduction
GHR20_RS17475	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS17480	COG1309	transcriptional regulator
GHR20_RS17490	COG1595	DNA-templated transcription, initiation
GHR20_RS17520	COG0701	Predicted permease
GHR20_RS17540	COG0494	nUDIX hydrolase
GHR20_RS17670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GHR20_RS17680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GHR20_RS17695	COG1741	Belongs to the pirin family
GHR20_RS17705	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS17710	COG1362	aminopeptidase activity
GHR20_RS17745	COG2271	Major facilitator Superfamily
GHR20_RS17780	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHR20_RS17785	COG0022	dehydrogenase e1 component
GHR20_RS17800	COG0515	serine threonine protein kinase
GHR20_RS17805	COG0515	serine threonine protein kinase
GHR20_RS17820	COG3321	synthase
GHR20_RS17820	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS17820	COG0604	alcohol dehydrogenase
GHR20_RS17825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GHR20_RS17830	COG0303	'Molybdopterin
GHR20_RS17835	COG0746	molybdenum cofactor guanylyltransferase activity
GHR20_RS17855	COG1522	sequence-specific DNA binding
GHR20_RS17860	COG1309	transcriptional regulator
GHR20_RS17865	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHR20_RS17890	COG3396	Phenylacetate-CoA oxygenase
GHR20_RS17895	COG3460	Phenylacetate-CoA oxygenase
GHR20_RS17900	COG3396	Phenylacetate-CoA oxygenase
GHR20_RS17905	COG2151	metal-sulfur cluster biosynthetic enzyme
GHR20_RS17910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GHR20_RS17940	COG0477	Major facilitator Superfamily
GHR20_RS17965	COG1716	ATPase activity
GHR20_RS17970	COG1716	ATPase activity
GHR20_RS17975	COG3266	domain, Protein
GHR20_RS17975	COG0631	protein serine/threonine phosphatase activity
GHR20_RS17985	COG0768	penicillin binding
GHR20_RS17990	COG0515	serine threonine protein kinase
GHR20_RS17995	COG3764	Sortase (surface protein transpeptidase)
GHR20_RS18000	COG3764	Sortase (surface protein transpeptidase)
GHR20_RS18015	COG3764	Sortase (surface protein transpeptidase)
GHR20_RS18030	COG0705	Rhomboid family
GHR20_RS18065	COG5285	phytanoyl-CoA dioxygenase
GHR20_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS18075	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GHR20_RS18085	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS18110	COG0583	DNA-binding transcription factor activity
GHR20_RS18135	COG0515	serine threonine protein kinase
GHR20_RS18170	COG2319	Wd-40 repeat
GHR20_RS18170	COG4249	Peptidase C14 caspase catalytic subunit p20
GHR20_RS18195	COG3266	domain, Protein
GHR20_RS18200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GHR20_RS18205	COG0187	DNA topoisomerase II activity
GHR20_RS18210	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GHR20_RS18215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GHR20_RS18220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GHR20_RS18225	COG0592	DNA-directed DNA polymerase activity
GHR20_RS18235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GHR20_RS18240	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GHR20_RS18245	COG0594	ribonuclease P activity
GHR20_RS18250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GHR20_RS18255	COG0706	membrane insertase activity
GHR20_RS18265	COG0357	Ribosomal RNA small subunit methyltransferase G
GHR20_RS18270	COG1192	Involved in chromosome partitioning
GHR20_RS18285	COG3118	belongs to the thioredoxin family
GHR20_RS18290	COG0492	ferredoxin-NADP+ reductase activity
GHR20_RS18300	COG1595	DNA-templated transcription, initiation
GHR20_RS18320	COG0617	tRNA 3'-terminal CCA addition
GHR20_RS18330	COG1260	myo-inositol-1-phosphate synthase
GHR20_RS18340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GHR20_RS18365	COG0360	Binds together with S18 to 16S ribosomal RNA
GHR20_RS18370	COG0629	single-stranded DNA binding
GHR20_RS18375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GHR20_RS18380	COG0359	binds to the 23S rRNA
GHR20_RS18390	COG0305	Participates in initiation and elongation during chromosome replication
GHR20_RS18405	COG0529	Catalyzes the synthesis of activated sulfate
GHR20_RS18405	COG2046	Belongs to the sulfate adenylyltransferase family
GHR20_RS18425	COG2814	Major facilitator Superfamily
GHR20_RS18445	COG0626	cystathionine gamma-synthase activity
GHR20_RS18450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GHR20_RS18455	COG1950	PFAM Membrane protein of
GHR20_RS18460	COG0662	Cupin 2, conserved barrel domain protein
GHR20_RS18470	COG1414	Transcriptional regulator
GHR20_RS18485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GHR20_RS18500	COG1609	Transcriptional regulator
GHR20_RS18505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GHR20_RS18510	COG1271	oxidase subunit
GHR20_RS18515	COG1294	oxidase, subunit
GHR20_RS18520	COG4988	ABC transporter
GHR20_RS18525	COG0561	phosphatase activity
GHR20_RS18550	COG1131	(ABC) transporter
GHR20_RS18575	COG0561	phosphatase activity
GHR20_RS18580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GHR20_RS18590	COG2837	iron assimilation
GHR20_RS18605	COG1999	signal sequence binding
GHR20_RS18625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHR20_RS18640	COG0006	proline dipeptidase activity
GHR20_RS18660	COG0653	protein targeting
GHR20_RS18675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHR20_RS18710	COG1595	DNA-templated transcription, initiation
GHR20_RS18715	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS18785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GHR20_RS18805	COG0745	RESPONSE REGULATOR receiver
GHR20_RS18810	COG2205	protein histidine kinase activity
GHR20_RS18815	COG0463	Glycosyl transferase, family 2
GHR20_RS18820	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GHR20_RS18830	COG3467	pyridoxamine 5'-phosphate
GHR20_RS18865	COG1191	sigma factor activity
GHR20_RS18870	COG1191	sigma factor activity
GHR20_RS18905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GHR20_RS18920	COG0433	COG0433 Predicted ATPase
GHR20_RS18950	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS18990	COG0242	peptide deformylase activity
GHR20_RS19030	COG0494	nUDIX hydrolase
GHR20_RS19100	COG0151	Belongs to the GarS family
GHR20_RS19115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GHR20_RS19125	COG2197	response regulator
GHR20_RS19160	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GHR20_RS19165	COG0047	phosphoribosylformylglycinamidine synthase activity
GHR20_RS19170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GHR20_RS19195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GHR20_RS19225	COG1643	Atp-dependent helicase
GHR20_RS19270	COG0513	Belongs to the DEAD box helicase family
GHR20_RS19295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GHR20_RS19300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GHR20_RS19325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GHR20_RS19330	COG0579	oxidoreductase
GHR20_RS19360	COG1252	NADH dehydrogenase
GHR20_RS19365	COG2208	phosphoserine phosphatase activity
GHR20_RS19365	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS19365	COG2172	sigma factor antagonist activity
GHR20_RS19370	COG2226	methyltransferase
GHR20_RS19460	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS19470	COG0791	NLP P60 protein
GHR20_RS19475	COG0671	phosphoesterase, PA-phosphatase related
GHR20_RS19480	COG0277	FAD linked oxidase domain protein
GHR20_RS19500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GHR20_RS19530	COG0306	phosphate transporter
GHR20_RS19540	COG1937	Protein conserved in bacteria
GHR20_RS19550	COG0494	nUDIX hydrolase
GHR20_RS19550	COG0406	alpha-ribazole phosphatase activity
GHR20_RS19560	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GHR20_RS19570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GHR20_RS19575	COG1725	Transcriptional regulator
GHR20_RS19580	COG0456	acetyltransferase
GHR20_RS19585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GHR20_RS19595	COG0745	RESPONSE REGULATOR receiver
GHR20_RS19605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHR20_RS19610	COG1609	Transcriptional regulator
GHR20_RS19615	COG0745	RESPONSE REGULATOR receiver
GHR20_RS19650	COG2897	thiosulfate sulfurtransferase activity
GHR20_RS19665	COG3485	protocatechuate 3,4-dioxygenase
GHR20_RS19680	COG1490	D-aminoacyl-tRNA deacylase activity
GHR20_RS19690	COG4552	Acetyltransferase involved in intracellular survival and related
GHR20_RS19695	COG2188	Transcriptional regulator
GHR20_RS19705	COG2186	Transcriptional regulator
GHR20_RS19710	COG0546	phosphoglycolate phosphatase activity
GHR20_RS19730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GHR20_RS19740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GHR20_RS19765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GHR20_RS19790	COG3883	PFAM NLP P60 protein
GHR20_RS19790	COG0791	NLP P60 protein
GHR20_RS19800	COG0438	transferase activity, transferring glycosyl groups
GHR20_RS19830	COG0588	phosphoglycerate mutase activity
GHR20_RS19865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GHR20_RS19870	COG0798	PFAM Bile acid sodium symporter
GHR20_RS19875	COG0640	Transcriptional regulator
GHR20_RS19885	COG1278	Cold shock
GHR20_RS19890	COG0513	Belongs to the DEAD box helicase family
GHR20_RS19920	COG5002	protein histidine kinase activity
GHR20_RS19940	COG1329	Transcriptional regulator
GHR20_RS19945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GHR20_RS19950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GHR20_RS19960	COG0215	cysteine-tRNA ligase activity
GHR20_RS19965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GHR20_RS19975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GHR20_RS19985	COG3842	ATPase activity
GHR20_RS19995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHR20_RS20000	COG2329	Antibiotic biosynthesis monooxygenase
GHR20_RS20015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHR20_RS20020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GHR20_RS20025	COG2867	negative regulation of translational initiation
GHR20_RS20085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GHR20_RS20100	COG3300	MHYT domain
GHR20_RS20100	COG5001	Diguanylate cyclase
GHR20_RS20125	COG1653	transport
GHR20_RS20145	COG0463	Glycosyl transferase, family 2
GHR20_RS20160	COG1278	Cold shock
GHR20_RS20165	COG0459	protein refolding
GHR20_RS20180	COG4106	trans-aconitate 2-methyltransferase activity
GHR20_RS20185	COG1263	PTS System
GHR20_RS20185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GHR20_RS20190	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GHR20_RS20195	COG1737	Transcriptional regulator
GHR20_RS20235	COG2268	Band 7 protein
GHR20_RS20245	COG3973	AAA domain
GHR20_RS20255	COG1061	Type III restriction enzyme res subunit
GHR20_RS20280	COG1278	Cold shock
GHR20_RS20285	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GHR20_RS20290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GHR20_RS20300	COG2814	Major facilitator Superfamily
GHR20_RS20325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GHR20_RS20335	COG2252	PERMEase
GHR20_RS20365	COG0667	Aldo Keto reductase
GHR20_RS20415	COG0247	lactate metabolic process
GHR20_RS20415	COG0277	FAD linked oxidase domain protein
GHR20_RS20445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHR20_RS20460	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS20465	COG1024	Enoyl-CoA hydratase
GHR20_RS20485	COG0259	pyridoxamine-phosphate oxidase activity
GHR20_RS20500	COG4821	SIS domain
GHR20_RS20605	COG0494	nUDIX hydrolase
GHR20_RS20630	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS20640	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS20645	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS20665	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS20695	COG1024	Enoyl-CoA hydratase
GHR20_RS20705	COG2072	flavoprotein involved in K transport
GHR20_RS20720	COG0259	pyridoxamine-phosphate oxidase activity
GHR20_RS20735	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS20740	COG1280	lysine exporter protein (LysE YggA)
GHR20_RS20745	COG1522	sequence-specific DNA binding
GHR20_RS20750	COG1309	transcriptional regulator
GHR20_RS20765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHR20_RS20765	COG0515	serine threonine protein kinase
GHR20_RS20770	COG1024	Enoyl-CoA hydratase
GHR20_RS20795	COG3629	intracellular signal transduction
GHR20_RS20795	COG3903	Transcriptional regulator
GHR20_RS20810	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS20825	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS20840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GHR20_RS20920	COG0386	Belongs to the glutathione peroxidase family
GHR20_RS21005	COG1846	Transcriptional regulator
GHR20_RS21010	COG3384	dioxygenase
GHR20_RS21070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GHR20_RS21080	COG0477	Major facilitator Superfamily
GHR20_RS21100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GHR20_RS21105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GHR20_RS21115	COG0315	cyclic pyranopterin monophosphate synthase activity
GHR20_RS21120	COG0521	Mo-molybdopterin cofactor biosynthetic process
GHR20_RS21120	COG0315	cyclic pyranopterin monophosphate synthase activity
GHR20_RS21125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GHR20_RS21145	COG0708	Exodeoxyribonuclease III
GHR20_RS21150	COG0789	Transcriptional regulator
GHR20_RS21155	COG2072	flavoprotein involved in K transport
GHR20_RS21165	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS21185	COG2409	Drug exporters of the RND superfamily
GHR20_RS21250	COG0084	hydrolase, TatD family'
GHR20_RS21260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GHR20_RS21265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GHR20_RS21270	COG0488	(ABC) transporter
GHR20_RS21320	COG2197	response regulator
GHR20_RS21330	COG4106	trans-aconitate 2-methyltransferase activity
GHR20_RS21340	COG1309	transcriptional regulator
GHR20_RS21350	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GHR20_RS21360	COG0193	aminoacyl-tRNA hydrolase activity
GHR20_RS21365	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GHR20_RS21370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GHR20_RS21375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GHR20_RS21390	COG4585	Histidine kinase
GHR20_RS21425	COG1136	(ABC) transporter
GHR20_RS21430	COG0577	efflux transmembrane transporter activity
GHR20_RS21490	COG2124	cytochrome p450
GHR20_RS21510	COG0148	phosphopyruvate hydratase activity
GHR20_RS21530	COG1252	NADH dehydrogenase
GHR20_RS21535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHR20_RS21540	COG0577	efflux transmembrane transporter activity
GHR20_RS21545	COG0577	efflux transmembrane transporter activity
GHR20_RS21545	COG1136	(ABC) transporter
GHR20_RS21575	COG0183	Belongs to the thiolase family
GHR20_RS21580	COG2755	lipolytic protein G-D-S-L family
GHR20_RS21630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHR20_RS21665	COG0745	RESPONSE REGULATOR receiver
GHR20_RS21670	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS21675	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS21690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GHR20_RS21700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GHR20_RS21705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GHR20_RS21705	COG0519	Catalyzes the synthesis of GMP from XMP
GHR20_RS21710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GHR20_RS21730	COG0789	Transcriptional regulator
GHR20_RS21775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GHR20_RS21780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHR20_RS21790	COG1228	amidohydrolase
GHR20_RS21795	COG1191	sigma factor activity
GHR20_RS21800	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS21825	COG3104	oligopeptide transport
GHR20_RS21830	COG0745	RESPONSE REGULATOR receiver
GHR20_RS21835	COG2205	protein histidine kinase activity
GHR20_RS21850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GHR20_RS21875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GHR20_RS21890	COG1316	TRANSCRIPTIONal
GHR20_RS21900	COG1316	TRANSCRIPTIONal
GHR20_RS21910	COG1316	TRANSCRIPTIONal
GHR20_RS21915	COG1316	TRANSCRIPTIONal
GHR20_RS21940	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GHR20_RS21940	COG0778	Nitroreductase
GHR20_RS21945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GHR20_RS21995	COG2835	tetraacyldisaccharide 4'-kinase activity
GHR20_RS22005	COG1482	cell wall glycoprotein biosynthetic process
GHR20_RS22015	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GHR20_RS22055	COG0714	Associated with various cellular activities
GHR20_RS22075	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GHR20_RS22080	COG0745	RESPONSE REGULATOR receiver
GHR20_RS22085	COG5000	phosphorelay sensor kinase activity
GHR20_RS22085	COG5002	protein histidine kinase activity
GHR20_RS22090	COG0823	Involved in the tonB-independent uptake of proteins
GHR20_RS22100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GHR20_RS22105	COG2197	response regulator
GHR20_RS22110	COG3214	Protein conserved in bacteria
GHR20_RS22120	COG0653	protein targeting
GHR20_RS22145	COG2902	Dehydrogenase
GHR20_RS22155	COG1215	transferase activity, transferring glycosyl groups
GHR20_RS22165	COG1134	teichoic acid transport
GHR20_RS22175	COG1309	transcriptional regulator
GHR20_RS22185	COG1215	transferase activity, transferring glycosyl groups
GHR20_RS22200	COG1846	Transcriptional regulator
GHR20_RS22205	COG1764	response to oxidative stress
GHR20_RS22210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GHR20_RS22215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GHR20_RS22220	COG1216	Glycosyl transferase, family 2
GHR20_RS22290	COG0395	ABC-type sugar transport system, permease component
GHR20_RS22295	COG1175	transmembrane transport
GHR20_RS22300	COG1653	transport
GHR20_RS22305	COG1674	ftsk spoiiie
GHR20_RS22310	COG0515	serine threonine protein kinase
GHR20_RS22320	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GHR20_RS22335	COG2884	Cell division ATP-binding protein ftsE
GHR20_RS22340	COG2177	Part of the ABC transporter FtsEX involved in
GHR20_RS22345	COG0793	Belongs to the peptidase S41A family
GHR20_RS22350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GHR20_RS22360	COG2226	methyltransferase
GHR20_RS22380	COG0776	regulation of translation
GHR20_RS22385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GHR20_RS22390	COG1678	Uncharacterized ACR, COG1678
GHR20_RS22400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GHR20_RS22465	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GHR20_RS22475	COG0277	FAD linked oxidase domain protein
GHR20_RS22510	COG1335	isochorismatase
GHR20_RS22520	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GHR20_RS22530	COG1113	amino acid transport
GHR20_RS22570	COG1263	PTS System
GHR20_RS22575	COG1263	PTS System
GHR20_RS22580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GHR20_RS22585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GHR20_RS22600	COG1131	(ABC) transporter
GHR20_RS22615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GHR20_RS22655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GHR20_RS22665	COG2733	membrane
GHR20_RS22680	COG0071	Belongs to the small heat shock protein (HSP20) family
GHR20_RS22690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GHR20_RS22750	COG3764	Sortase (surface protein transpeptidase)
GHR20_RS22770	COG0706	membrane insertase activity
GHR20_RS22785	COG4702	Belongs to the UPF0303 family
GHR20_RS22790	COG0673	inositol 2-dehydrogenase activity
GHR20_RS22815	COG2188	Transcriptional regulator
GHR20_RS22865	COG2186	Transcriptional regulator
GHR20_RS22885	COG3397	chitin binding
GHR20_RS22900	COG1126	abc transporter atp-binding protein
GHR20_RS22905	COG0765	amino acid transport
GHR20_RS22910	COG0765	amino acid transport
GHR20_RS22915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHR20_RS22920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GHR20_RS22930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS23005	COG0745	RESPONSE REGULATOR receiver
GHR20_RS23015	COG3979	chitinase
GHR20_RS23045	COG0589	response to stress
GHR20_RS23055	COG4977	sequence-specific DNA binding
GHR20_RS23060	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GHR20_RS23070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GHR20_RS23095	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GHR20_RS23120	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS23135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHR20_RS23140	COG1309	transcriptional regulator
GHR20_RS23150	COG1946	Acyl-CoA thioesterase
GHR20_RS23175	COG0028	Belongs to the TPP enzyme family
GHR20_RS23205	COG1472	Belongs to the glycosyl hydrolase 3 family
GHR20_RS23220	COG1609	Transcriptional regulator
GHR20_RS23225	COG0673	inositol 2-dehydrogenase activity
GHR20_RS23240	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS23275	COG1869	D-ribose catabolic process
GHR20_RS23280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHR20_RS23290	COG1129	ABC transporter
GHR20_RS23305	COG1902	pentaerythritol trinitrate reductase activity
GHR20_RS23305	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHR20_RS23310	COG1846	Transcriptional regulator
GHR20_RS23320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GHR20_RS23345	COG1063	alcohol dehydrogenase
GHR20_RS23355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHR20_RS23365	COG3718	enzyme involved in inositol metabolism
GHR20_RS23370	COG3962	Belongs to the TPP enzyme family
GHR20_RS23385	COG1131	(ABC) transporter
GHR20_RS23450	COG2304	oxidoreductase activity
GHR20_RS23460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GHR20_RS23470	COG1733	regulation of RNA biosynthetic process
GHR20_RS23485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GHR20_RS23490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHR20_RS23520	COG0367	asparagine synthase
GHR20_RS23565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHR20_RS23570	COG2954	triphosphatase activity
GHR20_RS23585	COG0667	Aldo Keto reductase
GHR20_RS23650	COG0629	single-stranded DNA binding
GHR20_RS23685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHR20_RS23715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHR20_RS23730	COG1486	melibiose metabolic process
GHR20_RS23735	COG0395	ABC-type sugar transport system, permease component
GHR20_RS23740	COG1175	transmembrane transport
GHR20_RS23755	COG0668	transmembrane transport
GHR20_RS23790	COG1136	(ABC) transporter
GHR20_RS23825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHR20_RS23860	COG4221	oxidoreductase activity
GHR20_RS23875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GHR20_RS23885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GHR20_RS23895	COG1113	amino acid transport
GHR20_RS23915	COG1113	amino acid transport
GHR20_RS23960	COG0544	peptidyl-prolyl cis-trans isomerase activity
GHR20_RS23965	COG0740	serine-type endopeptidase activity
GHR20_RS23970	COG0740	serine-type endopeptidase activity
GHR20_RS23975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GHR20_RS23985	COG0525	valine-tRNA ligase activity
GHR20_RS23990	COG0285	dihydrofolate synthase activity
GHR20_RS24000	COG0105	UTP biosynthetic process
GHR20_RS24005	COG1077	Cell shape determining protein MreB Mrl
GHR20_RS24020	COG0768	penicillin binding
GHR20_RS24025	COG0772	Belongs to the SEDS family
GHR20_RS24065	COG1530	ribonuclease E activity
GHR20_RS24080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GHR20_RS24085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GHR20_RS24090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GHR20_RS24095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GHR20_RS24100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GHR20_RS24105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GHR20_RS24115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GHR20_RS24130	COG0501	Belongs to the peptidase M48B family
GHR20_RS24135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GHR20_RS24145	COG0799	negative regulation of ribosome biogenesis
GHR20_RS24150	COG0588	phosphoglycerate mutase activity
GHR20_RS24170	COG0495	leucyl-tRNA aminoacylation
GHR20_RS24180	COG1307	EDD domain protein, DegV family
GHR20_RS24185	COG1555	photosystem II stabilization
GHR20_RS24200	COG2353	YceI-like domain
GHR20_RS24215	COG0268	Binds directly to 16S ribosomal RNA
GHR20_RS24225	COG0481	GTPase activity
GHR20_RS24260	COG1420	regulation of RNA biosynthetic process
GHR20_RS24265	COG0484	heat shock protein binding
GHR20_RS24305	COG0537	adenosine 5'-monophosphoramidase activity
GHR20_RS24310	COG1234	tRNA 3'-trailer cleavage
GHR20_RS24315	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GHR20_RS24330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GHR20_RS24340	COG2315	Protein conserved in bacteria
GHR20_RS24380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GHR20_RS24410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GHR20_RS24430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHR20_RS24435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHR20_RS24440	COG4608	Belongs to the ABC transporter superfamily
GHR20_RS24445	COG0444	Belongs to the ABC transporter superfamily
GHR20_RS24455	COG0747	negative chemotaxis
GHR20_RS24470	COG1381	Involved in DNA repair and RecF pathway recombination
GHR20_RS24475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GHR20_RS24485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GHR20_RS24490	COG1121	(ABC) transporter
GHR20_RS24500	COG0423	glycine-tRNA ligase activity
GHR20_RS24510	COG0667	Aldo Keto reductase
GHR20_RS24525	COG0477	Major facilitator Superfamily
GHR20_RS24555	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GHR20_RS24560	COG1940	carbohydrate kinase activity
GHR20_RS24560	COG1846	Transcriptional regulator
GHR20_RS24565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GHR20_RS24565	COG0574	Belongs to the PEP-utilizing enzyme family
GHR20_RS24590	COG1175	transmembrane transport
GHR20_RS24595	COG0395	ABC-type sugar transport system, permease component
GHR20_RS24620	COG2949	membrane
GHR20_RS24625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GHR20_RS24635	COG0358	DNA primase activity
GHR20_RS24640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GHR20_RS24655	COG1070	Carbohydrate kinase
GHR20_RS24695	COG1077	Cell shape determining protein MreB Mrl
GHR20_RS24720	COG0825	malonyl-CoA metabolic process
GHR20_RS24720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GHR20_RS24725	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS24770	COG0477	Major facilitator Superfamily
GHR20_RS24785	COG2130	NADP-dependent
GHR20_RS24805	COG1335	isochorismatase
GHR20_RS24810	COG1335	isochorismatase
GHR20_RS24840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHR20_RS24845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GHR20_RS24850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHR20_RS24865	COG1741	Belongs to the pirin family
GHR20_RS24880	COG0789	Transcriptional regulator
GHR20_RS24885	COG0667	Aldo Keto reductase
GHR20_RS24900	COG1309	transcriptional regulator
GHR20_RS24905	COG0477	Major facilitator Superfamily
GHR20_RS24910	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GHR20_RS24955	COG1358	cellular component organization or biogenesis
GHR20_RS24970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GHR20_RS25050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHR20_RS25065	COG0456	acetyltransferase
GHR20_RS25085	COG0583	DNA-binding transcription factor activity
GHR20_RS25105	COG4122	O-methyltransferase activity
GHR20_RS25115	COG0477	Major facilitator Superfamily
GHR20_RS25125	COG0183	Belongs to the thiolase family
GHR20_RS25130	COG2124	cytochrome p450
GHR20_RS25135	COG3619	membrane
GHR20_RS25140	COG0741	lytic transglycosylase activity
GHR20_RS25150	COG3845	ABC transporter
GHR20_RS25165	COG1657	PFAM Prenyltransferase squalene oxidase
GHR20_RS25210	COG1309	transcriptional regulator
GHR20_RS25215	COG0438	transferase activity, transferring glycosyl groups
GHR20_RS25235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS25245	COG2247	cell wall binding repeat
GHR20_RS25245	COG0860	N-Acetylmuramoyl-L-alanine amidase
GHR20_RS25290	COG2197	response regulator
GHR20_RS25295	COG4585	Histidine kinase
GHR20_RS25305	COG1131	(ABC) transporter
GHR20_RS25310	COG2030	dehydratase
GHR20_RS25320	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS25330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GHR20_RS25345	COG0800	Aldolase
GHR20_RS25350	COG3022	response to hydroperoxide
GHR20_RS25445	COG2259	Doxx family
GHR20_RS25455	COG1686	Belongs to the peptidase S11 family
GHR20_RS25465	COG2814	Major facilitator Superfamily
GHR20_RS25470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GHR20_RS25490	COG0672	)-iron permease
GHR20_RS25495	COG2837	iron assimilation
GHR20_RS25505	COG1120	ATPase activity
GHR20_RS25510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHR20_RS25515	COG4558	Periplasmic binding protein
GHR20_RS25570	COG1994	Peptidase M50
GHR20_RS25590	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GHR20_RS25595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GHR20_RS25600	COG0477	Major facilitator Superfamily
GHR20_RS25615	COG2814	Major facilitator Superfamily
GHR20_RS25675	COG0583	DNA-binding transcription factor activity
GHR20_RS25685	COG0596	Alpha beta hydrolase
GHR20_RS25710	COG1959	2 iron, 2 sulfur cluster binding
GHR20_RS25715	COG1017	nitric oxide dioxygenase activity
GHR20_RS25715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GHR20_RS25735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GHR20_RS25745	COG1609	Transcriptional regulator
GHR20_RS25755	COG1175	transmembrane transport
GHR20_RS25760	COG3833	ABC-type maltose transport systems, permease component
GHR20_RS25765	COG0366	Alpha amylase catalytic
GHR20_RS25780	COG1309	transcriptional regulator
GHR20_RS25805	COG2197	response regulator
GHR20_RS25820	COG0745	RESPONSE REGULATOR receiver
GHR20_RS25850	COG0501	Belongs to the peptidase M48B family
GHR20_RS25865	COG0174	glutamine synthetase
GHR20_RS25885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GHR20_RS25890	COG0321	lipoyl(octanoyl) transferase activity
GHR20_RS25905	COG0454	-acetyltransferase
GHR20_RS25905	COG0456	acetyltransferase
GHR20_RS25930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GHR20_RS25940	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHR20_RS25945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GHR20_RS25950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GHR20_RS25955	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GHR20_RS25975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GHR20_RS25995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHR20_RS26020	COG4585	Histidine kinase
GHR20_RS26025	COG2197	response regulator
GHR20_RS26030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHR20_RS26035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GHR20_RS26065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHR20_RS26075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GHR20_RS26080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GHR20_RS26090	COG1376	ErfK ybiS ycfS ynhG family protein
GHR20_RS26100	COG1845	cytochrome c oxidase, subunit III
GHR20_RS26105	COG2010	Cytochrome c
GHR20_RS26110	COG0723	plastoquinol--plastocyanin reductase activity
GHR20_RS26115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GHR20_RS26120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GHR20_RS26125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GHR20_RS26155	COG3883	PFAM NLP P60 protein
GHR20_RS26155	COG0791	NLP P60 protein
GHR20_RS26170	COG0438	transferase activity, transferring glycosyl groups
GHR20_RS26190	COG0003	Pfam Anion-transporting ATPase
GHR20_RS26200	COG1940	carbohydrate kinase activity
GHR20_RS26225	COG4585	Histidine kinase
GHR20_RS26235	COG0205	6-phosphofructokinase activity
GHR20_RS26250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GHR20_RS26260	COG2193	ferroxidase activity
GHR20_RS26265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GHR20_RS26270	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GHR20_RS26275	COG0515	serine threonine protein kinase
GHR20_RS26275	COG2815	serine threonine protein kinase
GHR20_RS26280	COG2022	thiamine diphosphate biosynthetic process
GHR20_RS26290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHR20_RS26290	COG2022	thiamine diphosphate biosynthetic process
GHR20_RS26310	COG0352	thiamine-phosphate diphosphorylase activity
GHR20_RS26335	COG1309	transcriptional regulator
GHR20_RS26340	COG1511	domain protein
GHR20_RS26345	COG1132	(ABC) transporter
GHR20_RS26375	COG0714	Associated with various cellular activities
GHR20_RS26385	COG0275	rRNA processing
GHR20_RS26400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GHR20_RS26410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHR20_RS26415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GHR20_RS26425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GHR20_RS26430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GHR20_RS26435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GHR20_RS26440	COG1496	oxidoreductase activity
GHR20_RS26450	COG1799	cell septum assembly
GHR20_RS26465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GHR20_RS26480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GHR20_RS26490	COG2153	protein acetylation
GHR20_RS26535	COG0587	DNA-directed DNA polymerase activity
GHR20_RS26545	COG1432	Conserved Protein
GHR20_RS26565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GHR20_RS26585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GHR20_RS26590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GHR20_RS26595	COG0131	Imidazoleglycerol-phosphate dehydratase
GHR20_RS26600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GHR20_RS26605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GHR20_RS26610	COG0251	oxidation-reduction process
GHR20_RS26615	COG0107	imidazoleglycerol-phosphate synthase activity
GHR20_RS26625	COG0346	lactoylglutathione lyase activity
GHR20_RS26635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GHR20_RS26660	COG0134	indole-3-glycerol-phosphate synthase activity
GHR20_RS26670	COG0133	tryptophan synthase activity
GHR20_RS26675	COG0159	tryptophan synthase activity
GHR20_RS26695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GHR20_RS26700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHR20_RS26745	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS26750	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS26755	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS26785	COG1024	Enoyl-CoA hydratase
GHR20_RS26790	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS26795	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS26815	COG0287	Prephenate dehydrogenase
GHR20_RS26815	COG1605	Chorismate mutase
GHR20_RS26880	COG0683	leucine binding
GHR20_RS26885	COG2050	protein possibly involved in aromatic compounds catabolism
GHR20_RS26920	COG1643	Atp-dependent helicase
GHR20_RS26925	COG2226	methyltransferase
GHR20_RS26930	COG0539	negative regulation of cytoplasmic translation
GHR20_RS26945	COG0237	dephospho-CoA kinase activity
GHR20_RS26960	COG2226	methyltransferase
GHR20_RS27035	COG0598	Magnesium transport protein CorA
GHR20_RS27040	COG2226	methyltransferase
GHR20_RS27050	COG2313	pseudouridylate synthase activity
GHR20_RS27055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GHR20_RS27060	COG0584	glycerophosphoryl diester phosphodiesterase
GHR20_RS27070	COG0556	nucleotide-excision repair
GHR20_RS27090	COG0387	Pfam Sodium calcium exchanger
GHR20_RS27095	COG0477	Major facilitator Superfamily
GHR20_RS27100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GHR20_RS27110	COG0765	amino acid transport
GHR20_RS27115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHR20_RS27120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHR20_RS27130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GHR20_RS27140	COG1609	Transcriptional regulator
GHR20_RS27155	COG0322	excinuclease ABC activity
GHR20_RS27160	COG1660	Displays ATPase and GTPase activities
GHR20_RS27170	COG1481	regulation of sporulation
GHR20_RS27175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GHR20_RS27180	COG0126	phosphoglycerate kinase activity
GHR20_RS27185	COG0149	triose-phosphate isomerase activity
GHR20_RS27190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GHR20_RS27205	COG0166	Belongs to the GPI family
GHR20_RS27215	COG0363	glucosamine-6-phosphate deaminase activity
GHR20_RS27230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GHR20_RS27240	COG0109	protoheme IX farnesyltransferase activity
GHR20_RS27265	COG1131	(ABC) transporter
GHR20_RS27285	COG0719	Fe-S assembly protein
GHR20_RS27295	COG0396	ATPase activity
GHR20_RS27300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GHR20_RS27305	COG0822	iron-sulfur transferase activity
GHR20_RS27320	COG3226	Transcriptional regulator
GHR20_RS27325	COG2171	N-acyltransferase activity
GHR20_RS27335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHR20_RS27390	COG0395	ABC-type sugar transport system, permease component
GHR20_RS27395	COG1175	transmembrane transport
GHR20_RS27405	COG1349	DNA-binding transcription factor activity
GHR20_RS27420	COG0768	penicillin binding
GHR20_RS27450	COG5285	phytanoyl-CoA dioxygenase
GHR20_RS27455	COG1917	Cupin 2, conserved barrel domain protein
GHR20_RS27460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GHR20_RS27465	COG0456	acetyltransferase
GHR20_RS27470	COG2318	DinB family
GHR20_RS27475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GHR20_RS27485	COG0765	amino acid transport
GHR20_RS27510	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GHR20_RS27545	COG1797	cobyrinic acid a,c-diamide synthase activity
GHR20_RS27565	COG1492	cobalamin metabolic process
GHR20_RS27570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GHR20_RS27590	COG0235	Class ii aldolase
GHR20_RS27610	COG0488	(ABC) transporter
GHR20_RS27620	COG1024	Enoyl-CoA hydratase
GHR20_RS27630	COG1302	Protein conserved in bacteria
GHR20_RS27660	COG3387	PFAM Glycoside hydrolase 15-related
GHR20_RS27675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GHR20_RS27685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GHR20_RS27690	COG1404	Belongs to the peptidase S8 family
GHR20_RS27705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GHR20_RS27710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GHR20_RS27730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GHR20_RS27745	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS27760	COG2186	Transcriptional regulator
GHR20_RS27775	COG0588	phosphoglycerate mutase activity
GHR20_RS27780	COG0560	Phosphoserine phosphatase
GHR20_RS27780	COG3830	Belongs to the UPF0237 family
GHR20_RS27785	COG0842	Transport permease protein
GHR20_RS27785	COG1131	(ABC) transporter
GHR20_RS27785	COG1716	ATPase activity
GHR20_RS27800	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS27805	COG4585	Histidine kinase
GHR20_RS27810	COG2197	response regulator
GHR20_RS27825	COG1119	ATPase activity
GHR20_RS27845	COG1881	PFAM PEBP family protein
GHR20_RS27855	COG2094	Belongs to the DNA glycosylase MPG family
GHR20_RS27885	COG0647	UMP catabolic process
GHR20_RS27890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHR20_RS27895	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHR20_RS27900	COG1120	ATPase activity
GHR20_RS27920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GHR20_RS27925	COG0497	DNA recombination
GHR20_RS27950	COG3387	PFAM Glycoside hydrolase 15-related
GHR20_RS27955	COG0504	CTP synthase activity
GHR20_RS27960	COG0494	nUDIX hydrolase
GHR20_RS27970	COG0686	Belongs to the AlaDH PNT family
GHR20_RS27985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GHR20_RS27990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GHR20_RS27995	COG1187	pseudouridine synthase activity
GHR20_RS28005	COG3541	Predicted nucleotidyltransferase
GHR20_RS28030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GHR20_RS28040	COG1160	GTP binding
GHR20_RS28055	COG1652	LysM domain
GHR20_RS28065	COG0671	phosphoesterase, PA-phosphatase related
GHR20_RS28075	COG0477	Major facilitator Superfamily
GHR20_RS28080	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS28085	COG1799	cell septum assembly
GHR20_RS28095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHR20_RS28100	COG0765	amino acid transport
GHR20_RS28110	COG1126	abc transporter atp-binding protein
GHR20_RS28135	COG0587	DNA-directed DNA polymerase activity
GHR20_RS28145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GHR20_RS28145	COG0662	Cupin 2, conserved barrel domain protein
GHR20_RS28165	COG2226	methyltransferase
GHR20_RS28180	COG1725	Transcriptional regulator
GHR20_RS28205	COG1649	PFAM Uncharacterised BCR, COG1649
GHR20_RS28205	COG0726	polysaccharide deacetylase
GHR20_RS28225	COG2755	lipolytic protein G-D-S-L family
GHR20_RS28235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GHR20_RS28260	COG2188	Transcriptional regulator
GHR20_RS28265	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GHR20_RS28275	COG1309	transcriptional regulator
GHR20_RS28305	COG0640	Transcriptional regulator
GHR20_RS28315	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS28365	COG3876	Protein conserved in bacteria
GHR20_RS28375	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS28395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GHR20_RS28425	COG3265	gluconokinase activity
GHR20_RS28430	COG2186	Transcriptional regulator
GHR20_RS28435	COG3012	SEC-C Motif Domain Protein
GHR20_RS28450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GHR20_RS28450	COG1796	DNA polymerase
GHR20_RS28465	COG2226	methyltransferase
GHR20_RS28475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHR20_RS28505	COG0667	Aldo Keto reductase
GHR20_RS28510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHR20_RS28515	COG0598	Magnesium transport protein CorA
GHR20_RS28520	COG0406	alpha-ribazole phosphatase activity
GHR20_RS28535	COG0215	cysteine-tRNA ligase activity
GHR20_RS28545	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GHR20_RS28550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GHR20_RS28555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GHR20_RS28560	COG1414	Transcriptional regulator
GHR20_RS28565	COG1410	methionine synthase
GHR20_RS28565	COG0646	methionine synthase
GHR20_RS28570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHR20_RS28575	COG0747	negative chemotaxis
GHR20_RS28580	COG2197	response regulator
GHR20_RS28615	COG1222	aaa ATPase
GHR20_RS28620	COG4122	O-methyltransferase activity
GHR20_RS28640	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GHR20_RS28645	COG1609	Transcriptional regulator
GHR20_RS28655	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GHR20_RS28690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GHR20_RS28695	COG0805	protein transport
GHR20_RS28730	COG0564	pseudouridine synthase activity
GHR20_RS28750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GHR20_RS28755	COG0517	IMP dehydrogenase activity
GHR20_RS28755	COG4175	Glycine betaine
GHR20_RS28760	COG4176	ABC-type proline glycine betaine transport system permease component
GHR20_RS28770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GHR20_RS28790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GHR20_RS28800	COG0174	glutamine synthetase
GHR20_RS28805	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS28850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GHR20_RS28855	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GHR20_RS28860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GHR20_RS28865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GHR20_RS28870	COG5002	protein histidine kinase activity
GHR20_RS28875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GHR20_RS28880	COG0072	phenylalanine-tRNA ligase activity
GHR20_RS28880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GHR20_RS28910	COG1649	PFAM Uncharacterised BCR, COG1649
GHR20_RS28935	COG0463	Glycosyl transferase, family 2
GHR20_RS28955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GHR20_RS28960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GHR20_RS28965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GHR20_RS28970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHR20_RS28975	COG1438	arginine binding
GHR20_RS29015	COG0745	RESPONSE REGULATOR receiver
GHR20_RS29020	COG2205	protein histidine kinase activity
GHR20_RS29030	COG0137	argininosuccinate synthase activity
GHR20_RS29035	COG0165	Argininosuccinate lyase
GHR20_RS29050	COG0477	Major facilitator Superfamily
GHR20_RS29055	COG2132	Multicopper oxidase
GHR20_RS29085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHR20_RS29090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GHR20_RS29095	COG2011	ABC-type metal ion transport system permease component
GHR20_RS29100	COG1464	Belongs to the NlpA lipoprotein family
GHR20_RS29115	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GHR20_RS29120	COG1648	precorrin-2 dehydrogenase activity
GHR20_RS29120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GHR20_RS29170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GHR20_RS29225	COG5002	protein histidine kinase activity
GHR20_RS29225	COG2176	DNA-directed DNA polymerase activity
GHR20_RS29240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GHR20_RS29260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GHR20_RS29265	COG1560	Kdo2-lipid A biosynthetic process
GHR20_RS29270	COG0438	transferase activity, transferring glycosyl groups
GHR20_RS29280	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GHR20_RS29285	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GHR20_RS29290	COG0217	transcriptional regulatory protein
GHR20_RS29295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GHR20_RS29300	COG0632	four-way junction helicase activity
GHR20_RS29305	COG2255	four-way junction helicase activity
GHR20_RS29315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GHR20_RS29320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GHR20_RS29325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GHR20_RS29335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GHR20_RS29340	COG1196	nuclear chromosome segregation
GHR20_RS29345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GHR20_RS29355	COG0124	histidyl-tRNA synthetase
GHR20_RS29370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GHR20_RS29390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GHR20_RS29395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GHR20_RS29400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GHR20_RS29405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GHR20_RS29410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GHR20_RS29415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GHR20_RS29420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GHR20_RS29430	COG0006	proline dipeptidase activity
GHR20_RS29435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GHR20_RS29440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GHR20_RS29450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GHR20_RS29455	COG0540	Belongs to the ATCase OTCase family
GHR20_RS29460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GHR20_RS29470	COG0505	Belongs to the CarA family
GHR20_RS29475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GHR20_RS29480	COG0167	dihydroorotate dehydrogenase activity
GHR20_RS29485	COG0284	orotidine-5'-phosphate decarboxylase activity
GHR20_RS29495	COG0194	GDP metabolic process
GHR20_RS29510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GHR20_RS29530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GHR20_RS29540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GHR20_RS29545	COG2390	Transcriptional regulator
GHR20_RS29565	COG0531	amino acid
GHR20_RS29575	COG2188	Transcriptional regulator
GHR20_RS29595	COG3842	ATPase activity
GHR20_RS29600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHR20_RS29625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GHR20_RS29645	COG2233	PERMEase
GHR20_RS29655	COG0738	Major facilitator superfamily
GHR20_RS29660	COG1940	carbohydrate kinase activity
GHR20_RS29660	COG1846	Transcriptional regulator
GHR20_RS29670	COG3201	nicotinamide mononucleotide transporter
GHR20_RS29675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GHR20_RS29675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GHR20_RS29680	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GHR20_RS29685	COG0140	phosphoribosyl-ATP diphosphatase activity
GHR20_RS29690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GHR20_RS29745	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS29765	COG1216	Glycosyl transferase, family 2
GHR20_RS29780	COG2270	Major facilitator Superfamily
GHR20_RS29790	COG2364	Membrane
GHR20_RS29845	COG1984	allophanate hydrolase subunit 2
GHR20_RS29850	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GHR20_RS29855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GHR20_RS29860	COG4336	lyase activity
GHR20_RS29865	COG2814	Major facilitator Superfamily
GHR20_RS29905	COG2018	Roadblock/LC7 domain
GHR20_RS29950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GHR20_RS29960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GHR20_RS29990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GHR20_RS30010	COG1716	ATPase activity
GHR20_RS30030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GHR20_RS30040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GHR20_RS30040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GHR20_RS30115	COG0509	glycine decarboxylation via glycine cleavage system
GHR20_RS30165	COG0697	spore germination
GHR20_RS30205	COG0747	negative chemotaxis
GHR20_RS30210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GHR20_RS30220	COG2318	DinB family
GHR20_RS30225	COG0673	inositol 2-dehydrogenase activity
GHR20_RS30230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GHR20_RS30255	COG0183	Belongs to the thiolase family
GHR20_RS30270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GHR20_RS30290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS30290	COG3321	synthase
GHR20_RS30300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GHR20_RS30310	COG0596	Alpha beta hydrolase
GHR20_RS30315	COG1819	glycosyl
GHR20_RS30340	COG0110	maltose O-acetyltransferase activity
GHR20_RS30360	COG0531	amino acid
GHR20_RS30365	COG1832	CoA-binding protein
GHR20_RS30380	COG1739	Uncharacterized protein family UPF0029
GHR20_RS30385	COG0420	3'-5' exonuclease activity
GHR20_RS30390	COG0419	ATPase involved in DNA repair
GHR20_RS30425	COG0626	cystathionine gamma-synthase activity
GHR20_RS30440	COG0596	Alpha beta hydrolase
GHR20_RS30445	COG1595	DNA-templated transcription, initiation
GHR20_RS30450	COG2188	Transcriptional regulator
GHR20_RS30460	COG1940	carbohydrate kinase activity
GHR20_RS30465	COG2197	response regulator
GHR20_RS30470	COG4585	Histidine kinase
GHR20_RS30485	COG3663	DNA glycosylase
GHR20_RS30490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GHR20_RS30545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GHR20_RS30550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GHR20_RS30555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GHR20_RS30560	COG0156	8-amino-7-oxononanoate synthase activity
GHR20_RS30590	COG0740	serine-type endopeptidase activity
GHR20_RS30600	COG0831	urea catabolic process
GHR20_RS30605	COG0832	Belongs to the urease beta subunit family
GHR20_RS30610	COG0804	urea catabolic process
GHR20_RS30620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GHR20_RS30625	COG0829	nickel cation binding
GHR20_RS30630	COG0204	Acyl-transferase
GHR20_RS30640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHR20_RS30645	COG1834	amidinotransferase
GHR20_RS30650	COG1522	sequence-specific DNA binding
GHR20_RS30665	COG0205	6-phosphofructokinase activity
GHR20_RS30670	COG3442	glutamine amidotransferase
GHR20_RS30680	COG0242	peptide deformylase activity
GHR20_RS30690	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS30700	COG2124	cytochrome p450
GHR20_RS30705	COG3424	synthase
GHR20_RS30730	COG1793	dna ligase
GHR20_RS30745	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS30750	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS30860	COG0464	growth
GHR20_RS30885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GHR20_RS30890	COG2423	ornithine cyclodeaminase activity
GHR20_RS30920	COG3903	Transcriptional regulator
GHR20_RS30920	COG3629	intracellular signal transduction
GHR20_RS30945	COG3959	Transketolase, thiamine diphosphate binding domain
GHR20_RS30955	COG0443	Heat shock 70 kDa protein
GHR20_RS30960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GHR20_RS30970	COG2264	protein methyltransferase activity
GHR20_RS30975	COG0512	Glutamine amidotransferase of anthranilate synthase
GHR20_RS30975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GHR20_RS31000	COG0535	radical SAM domain protein
GHR20_RS31100	COG0714	Associated with various cellular activities
GHR20_RS31130	COG1819	glycosyl
GHR20_RS31145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHR20_RS31150	COG2267	carboxylic ester hydrolase activity
GHR20_RS31160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHR20_RS31165	COG2124	cytochrome p450
GHR20_RS31185	COG1012	belongs to the aldehyde dehydrogenase family
GHR20_RS31210	COG1940	carbohydrate kinase activity
GHR20_RS31210	COG1846	Transcriptional regulator
GHR20_RS31260	COG2018	Roadblock/LC7 domain
GHR20_RS31270	COG1946	Acyl-CoA thioesterase
GHR20_RS31285	COG0254	rRNA binding
GHR20_RS31295	COG1132	(ABC) transporter
GHR20_RS31330	COG1132	(ABC) transporter
GHR20_RS31340	COG2072	flavoprotein involved in K transport
GHR20_RS31345	COG0432	Pfam Uncharacterised protein family UPF0047
GHR20_RS31365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GHR20_RS31370	COG1472	Belongs to the glycosyl hydrolase 3 family
GHR20_RS31385	COG0714	Associated with various cellular activities
GHR20_RS31410	COG0477	Major facilitator Superfamily
GHR20_RS31415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHR20_RS31445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GHR20_RS31460	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS31480	COG1902	pentaerythritol trinitrate reductase activity
GHR20_RS31485	COG0640	Transcriptional regulator
GHR20_RS31500	COG1309	transcriptional regulator
GHR20_RS31520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHR20_RS31555	COG0584	glycerophosphoryl diester phosphodiesterase
GHR20_RS31595	COG2086	electron transfer activity
GHR20_RS31600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GHR20_RS31625	COG3345	alpha-galactosidase
GHR20_RS31645	COG1660	Displays ATPase and GTPase activities
GHR20_RS31650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHR20_RS31660	COG0445	tRNA wobble uridine modification
GHR20_RS31685	COG0180	Tryptophanyl-tRNA synthetase
GHR20_RS31695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHR20_RS31740	COG1595	DNA-templated transcription, initiation
GHR20_RS31750	COG1349	DNA-binding transcription factor activity
GHR20_RS31765	COG2813	Specifically methylates the guanine in position
GHR20_RS31785	COG1940	carbohydrate kinase activity
GHR20_RS31845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHR20_RS31890	COG1215	transferase activity, transferring glycosyl groups
GHR20_RS31895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GHR20_RS31920	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS31930	COG4716	Myosin-crossreactive antigen
GHR20_RS31935	COG0531	amino acid
GHR20_RS31940	COG2235	arginine
GHR20_RS31945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GHR20_RS31950	COG0549	Belongs to the carbamate kinase family
GHR20_RS31955	COG4191	Histidine kinase
GHR20_RS31995	COG3469	chitinase activity
GHR20_RS32005	COG1309	transcriptional regulator
GHR20_RS32010	COG2409	Drug exporters of the RND superfamily
GHR20_RS32015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GHR20_RS32030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GHR20_RS32045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GHR20_RS32075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GHR20_RS32080	COG1993	acr, cog1993
GHR20_RS32085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GHR20_RS32090	COG1968	undecaprenyl-diphosphatase activity
GHR20_RS32110	COG2066	Belongs to the glutaminase family
GHR20_RS32130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GHR20_RS32145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GHR20_RS32165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GHR20_RS32180	COG2890	protein-(glutamine-N5) methyltransferase activity
GHR20_RS32200	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHR20_RS32200	COG1902	pentaerythritol trinitrate reductase activity
GHR20_RS32225	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GHR20_RS32230	COG1461	Dihydroxyacetone kinase
GHR20_RS32235	COG2376	Dihydroxyacetone kinase
GHR20_RS32275	COG0464	growth
GHR20_RS32300	COG1674	ftsk spoiiie
GHR20_RS32325	COG1960	acyl-CoA dehydrogenase activity
GHR20_RS32335	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS32340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GHR20_RS32345	COG4989	oxidoreductase activity
GHR20_RS32355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHR20_RS32360	COG0561	phosphatase activity
GHR20_RS32365	COG0494	nUDIX hydrolase
GHR20_RS32380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GHR20_RS32405	COG1131	(ABC) transporter
GHR20_RS32410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GHR20_RS32415	COG0662	Cupin 2, conserved barrel domain protein
GHR20_RS32420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GHR20_RS32430	COG2070	2-Nitropropane dioxygenase
GHR20_RS32440	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS32465	COG1024	Enoyl-CoA hydratase
GHR20_RS32525	COG3511	phospholipase C
GHR20_RS32545	COG0367	asparagine synthase
GHR20_RS32585	COG3250	beta-galactosidase activity
GHR20_RS32590	COG0531	amino acid
GHR20_RS32615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GHR20_RS32625	COG0583	DNA-binding transcription factor activity
GHR20_RS32630	COG0667	Aldo Keto reductase
GHR20_RS32655	COG1191	sigma factor activity
GHR20_RS32680	COG0328	RNA-DNA hybrid ribonuclease activity
GHR20_RS32710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GHR20_RS32740	COG3852	Histidine kinase
GHR20_RS32745	COG0492	ferredoxin-NADP+ reductase activity
GHR20_RS32755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHR20_RS32775	COG3189	MarR family transcriptional regulator
GHR20_RS32795	COG5002	protein histidine kinase activity
GHR20_RS32845	COG1252	NADH dehydrogenase
GHR20_RS32860	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GHR20_RS32865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GHR20_RS32870	COG3281	Trehalose synthase
GHR20_RS32880	COG0366	Alpha amylase catalytic
GHR20_RS32920	COG0842	Transport permease protein
GHR20_RS32930	COG0181	hydroxymethylbilane synthase activity
GHR20_RS32935	COG1793	dna ligase
GHR20_RS32960	COG2208	phosphoserine phosphatase activity
GHR20_RS32975	COG0656	L-ascorbic acid biosynthetic process
GHR20_RS32995	COG0596	Alpha beta hydrolase
GHR20_RS33020	COG0009	L-threonylcarbamoyladenylate synthase
GHR20_RS33060	COG1335	isochorismatase
GHR20_RS33065	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GHR20_RS33070	COG0673	inositol 2-dehydrogenase activity
GHR20_RS33160	COG0709	Synthesizes selenophosphate from selenide and ATP
GHR20_RS33165	COG0243	molybdopterin cofactor binding
GHR20_RS33165	COG3383	formate dehydrogenase (NAD+) activity
GHR20_RS33170	COG3383	formate dehydrogenase (NAD+) activity
GHR20_RS33170	COG0243	molybdopterin cofactor binding
GHR20_RS33180	COG0437	4 iron, 4 sulfur cluster binding
GHR20_RS33205	COG0586	Pfam SNARE associated Golgi protein
GHR20_RS33210	COG0667	Aldo Keto reductase
GHR20_RS33250	COG0438	transferase activity, transferring glycosyl groups
GHR20_RS33260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GHR20_RS33265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GHR20_RS33310	COG1285	pathogenesis
GHR20_RS33315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GHR20_RS33315	COG1024	Enoyl-CoA hydratase
GHR20_RS33320	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GHR20_RS33325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GHR20_RS33330	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GHR20_RS33335	COG0298	carbon dioxide binding
GHR20_RS33350	COG0375	protein maturation
GHR20_RS33375	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GHR20_RS33415	COG0701	Predicted permease
GHR20_RS33430	COG0589	response to stress
GHR20_RS33435	COG0517	IMP dehydrogenase activity
GHR20_RS33450	COG0517	IMP dehydrogenase activity
GHR20_RS33450	COG0516	GMP reductase activity
GHR20_RS33465	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GHR20_RS33470	COG1063	alcohol dehydrogenase
GHR20_RS33490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GHR20_RS33490	COG0617	tRNA 3'-terminal CCA addition
GHR20_RS33490	COG0517	IMP dehydrogenase activity
GHR20_RS33535	COG0640	Transcriptional regulator
GHR20_RS33540	COG1316	TRANSCRIPTIONal
GHR20_RS33555	COG1090	epimerase
GHR20_RS33565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHR20_RS33570	COG2409	Drug exporters of the RND superfamily
GHR20_RS33585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GHR20_RS33595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHR20_RS33615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHR20_RS33630	COG0745	RESPONSE REGULATOR receiver
GHR20_RS33635	COG5002	protein histidine kinase activity
GHR20_RS33650	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS33650	COG2172	sigma factor antagonist activity
GHR20_RS33650	COG2208	phosphoserine phosphatase activity
GHR20_RS33665	COG2080	2 iron, 2 sulfur cluster binding
GHR20_RS33670	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GHR20_RS33675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GHR20_RS33680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GHR20_RS33680	COG3608	succinylglutamate desuccinylase aspartoacylase
GHR20_RS33695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GHR20_RS33715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHR20_RS33745	COG1584	GPR1 FUN34 yaaH family protein
GHR20_RS33775	COG4585	Histidine kinase
GHR20_RS33780	COG2197	response regulator
GHR20_RS33790	COG0583	DNA-binding transcription factor activity
GHR20_RS33815	COG0516	GMP reductase activity
GHR20_RS33815	COG0517	IMP dehydrogenase activity
GHR20_RS33820	COG0589	response to stress
GHR20_RS33855	COG2837	iron assimilation
GHR20_RS33880	COG2755	lipolytic protein G-D-S-L family
GHR20_RS33910	COG3979	chitinase
GHR20_RS33925	COG1132	(ABC) transporter
GHR20_RS33955	COG0277	FAD linked oxidase domain protein
GHR20_RS33960	COG1597	lipid kinase activity
GHR20_RS33970	COG2837	iron assimilation
GHR20_RS33975	COG0542	response to heat
GHR20_RS33980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHR20_RS34005	COG1396	sequence-specific DNA binding
GHR20_RS34035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GHR20_RS34075	COG0456	acetyltransferase
GHR20_RS34120	COG2132	Multicopper oxidase
GHR20_RS34125	COG1703	isobutyryl-CoA mutase activity
GHR20_RS34125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GHR20_RS34125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GHR20_RS34140	COG0789	Transcriptional regulator
GHR20_RS34155	COG2226	methyltransferase
GHR20_RS34175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GHR20_RS34195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GHR20_RS34235	COG0477	Major facilitator Superfamily
GHR20_RS34240	COG1846	Transcriptional regulator
GHR20_RS34270	COG2239	Acts as a magnesium transporter
GHR20_RS34345	COG4948	Mandelate Racemase Muconate Lactonizing
GHR20_RS34350	COG1414	Transcriptional regulator
GHR20_RS34365	COG3896	Chloramphenicol phosphotransferase-like protein
GHR20_RS34390	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GHR20_RS34400	COG1609	Transcriptional regulator
GHR20_RS34410	COG1879	ABC-type sugar transport system periplasmic component
GHR20_RS34415	COG1129	ABC transporter
GHR20_RS34420	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHR20_RS34425	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHR20_RS34430	COG1609	Transcriptional regulator
GHR20_RS34450	COG4977	sequence-specific DNA binding
GHR20_RS34480	COG1278	Cold shock
GHR20_RS34485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GHR20_RS34555	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GHR20_RS34605	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GHR20_RS34655	COG0318	PFAM AMP-dependent synthetase and ligase
GHR20_RS34660	COG3433	isochorismatase activity
GHR20_RS34660	COG1535	isochorismatase
GHR20_RS34665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHR20_RS34690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHR20_RS34695	COG1120	ATPase activity
GHR20_RS34715	COG1846	Transcriptional regulator
GHR20_RS34720	COG2409	Drug exporters of the RND superfamily
GHR20_RS34735	COG3046	protein related to deoxyribodipyrimidine photolyase
GHR20_RS34745	COG1233	COG1233 Phytoene dehydrogenase and related
GHR20_RS34780	COG0702	epimerase
GHR20_RS34815	COG2124	cytochrome p450
GHR20_RS34820	COG0477	Major facilitator Superfamily
GHR20_RS34835	COG0702	epimerase
GHR20_RS34840	COG1733	regulation of RNA biosynthetic process
GHR20_RS34845	COG0277	FAD linked oxidase domain protein
GHR20_RS34865	COG1175	transmembrane transport
GHR20_RS34870	COG0395	ABC-type sugar transport system, permease component
GHR20_RS34875	COG0366	Alpha amylase catalytic
GHR20_RS34885	COG2124	cytochrome p450
GHR20_RS34905	COG3251	PFAM MbtH domain protein
GHR20_RS34915	COG2814	Major facilitator Superfamily
GHR20_RS34945	COG0604	alcohol dehydrogenase
GHR20_RS34945	COG3321	synthase
GHR20_RS34965	COG0604	alcohol dehydrogenase
GHR20_RS34975	COG2124	cytochrome p450
GHR20_RS35020	COG1309	transcriptional regulator
GHR20_RS35050	COG0395	ABC-type sugar transport system, permease component
GHR20_RS35055	COG1175	transmembrane transport
GHR20_RS35065	COG1609	Transcriptional regulator
GHR20_RS35125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHR20_RS35130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHR20_RS35145	COG1595	DNA-templated transcription, initiation
GHR20_RS35165	COG3534	alpha-L-arabinofuranosidase
GHR20_RS35175	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS35190	COG1309	transcriptional regulator
GHR20_RS35205	COG1349	DNA-binding transcription factor activity
GHR20_RS35220	COG3693	PFAM glycoside hydrolase, family 10
GHR20_RS35250	COG0028	Belongs to the TPP enzyme family
GHR20_RS35255	COG0069	glutamate synthase activity
GHR20_RS35260	COG1733	regulation of RNA biosynthetic process
GHR20_RS35295	COG0702	epimerase
GHR20_RS35305	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GHR20_RS35315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GHR20_RS35435	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GHR20_RS35440	COG0477	Major facilitator Superfamily
GHR20_RS35480	COG1191	sigma factor activity
GHR20_RS35510	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS35545	COG0009	L-threonylcarbamoyladenylate synthase
GHR20_RS35565	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS35570	COG1366	Belongs to the anti-sigma-factor antagonist family
GHR20_RS35615	COG0633	Ferredoxin
GHR20_RS35615	COG3217	Mosc domain protein beta barrel domain protein
GHR20_RS35710	COG1295	ribonuclease BN
GHR20_RS35710	COG1959	2 iron, 2 sulfur cluster binding
GHR20_RS35750	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GHR20_RS35795	COG4251	negative regulation of phosphorylation
GHR20_RS35805	COG0784	Response regulator, receiver
GHR20_RS35815	COG1846	Transcriptional regulator
GHR20_RS35825	COG1733	regulation of RNA biosynthetic process
GHR20_RS35855	COG1773	rubredoxin
GHR20_RS35905	COG0477	Major facilitator Superfamily
GHR20_RS35915	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS35960	COG2084	Dehydrogenase
GHR20_RS35975	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS35975	COG0604	alcohol dehydrogenase
GHR20_RS35975	COG3321	synthase
GHR20_RS36020	COG4251	negative regulation of phosphorylation
GHR20_RS36030	COG0784	Response regulator, receiver
GHR20_RS36040	COG0142	geranyltranstransferase activity
GHR20_RS36045	COG1119	ATPase activity
GHR20_RS36050	COG1024	Enoyl-CoA hydratase
GHR20_RS36055	COG2124	cytochrome p450
GHR20_RS36065	COG0583	DNA-binding transcription factor activity
GHR20_RS36075	COG1028	Short-chain dehydrogenase reductase Sdr
GHR20_RS36080	COG1959	2 iron, 2 sulfur cluster binding
GHR20_RS36085	COG1309	transcriptional regulator
GHR20_RS36130	COG1595	DNA-templated transcription, initiation
GHR20_RS36150	COG0640	Transcriptional regulator
GHR20_RS36190	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GHR20_RS36285	COG3883	PFAM NLP P60 protein
GHR20_RS36285	COG0791	NLP P60 protein
GHR20_RS36370	COG1518	maintenance of DNA repeat elements
GHR20_RS36375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GHR20_RS36385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GHR20_RS36390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GHR20_RS36455	COG2801	Transposase and inactivated derivatives
GHR20_RS36470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP