locus-tag	class	description
B6R96_RS00105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6R96_RS00230	COG0740	serine-type endopeptidase activity
B6R96_RS00235	COG0740	serine-type endopeptidase activity
B6R96_RS00310	COG0640	Transcriptional regulator
B6R96_RS00385	COG0596	Alpha beta hydrolase
B6R96_RS00460	COG2124	cytochrome p450
B6R96_RS00500	COG0646	methionine synthase
B6R96_RS00500	COG1410	methionine synthase
B6R96_RS00505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6R96_RS00510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B6R96_RS00520	COG2132	Multicopper oxidase
B6R96_RS00550	COG0135	phosphoribosylanthranilate isomerase activity
B6R96_RS00555	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS00560	COG0662	Cupin 2, conserved barrel domain protein
B6R96_RS00565	COG0159	tryptophan synthase activity
B6R96_RS00570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6R96_RS00580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS00585	COG2030	dehydratase
B6R96_RS00590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6R96_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS00610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6R96_RS00625	COG2072	flavoprotein involved in K transport
B6R96_RS00670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS00685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6R96_RS00690	COG1104	cysteine desulfurase activity
B6R96_RS00805	COG2319	Wd-40 repeat
B6R96_RS00805	COG4249	Peptidase C14 caspase catalytic subunit p20
B6R96_RS00845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B6R96_RS00895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6R96_RS00905	COG0438	transferase activity, transferring glycosyl groups
B6R96_RS00910	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS00925	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS00955	COG0583	DNA-binding transcription factor activity
B6R96_RS01015	COG0513	Belongs to the DEAD box helicase family
B6R96_RS01020	COG1278	Cold shock
B6R96_RS01025	COG2205	protein histidine kinase activity
B6R96_RS01030	COG0745	RESPONSE REGULATOR receiver
B6R96_RS01035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B6R96_RS01040	COG1088	dTDP-glucose 4,6-dehydratase activity
B6R96_RS01170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B6R96_RS01195	COG1309	transcriptional regulator
B6R96_RS01200	COG0667	Aldo Keto reductase
B6R96_RS01210	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS01220	COG3842	ATPase activity
B6R96_RS01225	COG1177	transmembrane transport
B6R96_RS01230	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6R96_RS01250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B6R96_RS01260	COG1042	CoA-binding domain protein
B6R96_RS01260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6R96_RS01260	COG0045	succinate-CoA ligase (ADP-forming) activity
B6R96_RS01265	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS01270	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS01280	COG1309	transcriptional regulator
B6R96_RS01300	COG1316	TRANSCRIPTIONal
B6R96_RS01355	COG3290	protein histidine kinase activity
B6R96_RS01370	COG3293	Transposase
B6R96_RS01390	COG0456	acetyltransferase
B6R96_RS01400	COG0308	aminopeptidase N
B6R96_RS01420	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B6R96_RS01435	COG0432	Pfam Uncharacterised protein family UPF0047
B6R96_RS01440	COG2205	protein histidine kinase activity
B6R96_RS01480	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B6R96_RS01485	COG0477	Major facilitator Superfamily
B6R96_RS01490	COG0745	RESPONSE REGULATOR receiver
B6R96_RS01495	COG2205	protein histidine kinase activity
B6R96_RS01645	COG0671	phosphoesterase, PA-phosphatase related
B6R96_RS01650	COG2197	response regulator
B6R96_RS01655	COG4585	Histidine kinase
B6R96_RS01660	COG0009	L-threonylcarbamoyladenylate synthase
B6R96_RS01685	COG0328	RNA-DNA hybrid ribonuclease activity
B6R96_RS01690	COG4585	Histidine kinase
B6R96_RS01705	COG2197	response regulator
B6R96_RS01720	COG1278	Cold shock
B6R96_RS01730	COG1595	DNA-templated transcription, initiation
B6R96_RS01785	COG2201	protein-glutamate methylesterase activity
B6R96_RS01795	COG0583	DNA-binding transcription factor activity
B6R96_RS01825	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS01845	COG0681	Belongs to the peptidase S26 family
B6R96_RS01895	COG1686	Belongs to the peptidase S11 family
B6R96_RS01905	COG2304	oxidoreductase activity
B6R96_RS01925	COG1764	response to oxidative stress
B6R96_RS01930	COG1846	Transcriptional regulator
B6R96_RS01935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B6R96_RS01935	COG1796	DNA polymerase
B6R96_RS01965	COG2272	Belongs to the type-B carboxylesterase lipase family
B6R96_RS01995	COG0714	Associated with various cellular activities
B6R96_RS02025	COG0666	response to abiotic stimulus
B6R96_RS02090	COG0477	Major facilitator Superfamily
B6R96_RS02095	COG0583	DNA-binding transcription factor activity
B6R96_RS02110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6R96_RS02120	COG2197	response regulator
B6R96_RS02130	COG2409	Drug exporters of the RND superfamily
B6R96_RS02135	COG4176	ABC-type proline glycine betaine transport system permease component
B6R96_RS02140	COG0517	IMP dehydrogenase activity
B6R96_RS02140	COG4175	Glycine betaine
B6R96_RS02145	COG2188	Transcriptional regulator
B6R96_RS02150	COG1846	Transcriptional regulator
B6R96_RS02175	COG2226	methyltransferase
B6R96_RS02180	COG0277	FAD linked oxidase domain protein
B6R96_RS02205	COG4585	Histidine kinase
B6R96_RS02210	COG2197	response regulator
B6R96_RS02235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS02240	COG1132	(ABC) transporter
B6R96_RS02260	COG0656	L-ascorbic acid biosynthetic process
B6R96_RS02270	COG1595	DNA-templated transcription, initiation
B6R96_RS02285	COG3265	gluconokinase activity
B6R96_RS02300	COG2124	cytochrome p450
B6R96_RS02310	COG1404	Belongs to the peptidase S8 family
B6R96_RS02310	COG4412	M6 family metalloprotease domain protein
B6R96_RS02310	COG1404	Belongs to the peptidase S8 family
B6R96_RS02310	COG4412	M6 family metalloprotease domain protein
B6R96_RS02315	COG0477	Major facilitator Superfamily
B6R96_RS02350	COG0598	Magnesium transport protein CorA
B6R96_RS02355	COG1793	dna ligase
B6R96_RS02360	COG1131	(ABC) transporter
B6R96_RS02370	COG0667	Aldo Keto reductase
B6R96_RS02380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B6R96_RS02425	COG1120	ATPase activity
B6R96_RS02430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6R96_RS02470	COG0800	Aldolase
B6R96_RS02475	COG1414	Transcriptional regulator
B6R96_RS02490	COG0076	glutamate decarboxylase activity
B6R96_RS02510	COG0789	Transcriptional regulator
B6R96_RS02530	COG4565	transcriptional regulatory protein
B6R96_RS02535	COG3290	protein histidine kinase activity
B6R96_RS02540	COG1301	dicarboxylic acid transport
B6R96_RS02570	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B6R96_RS02590	COG2304	oxidoreductase activity
B6R96_RS02605	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS02610	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS02625	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS02630	COG2378	regulation of single-species biofilm formation
B6R96_RS02645	COG1024	Enoyl-CoA hydratase
B6R96_RS02680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6R96_RS02695	COG0515	serine threonine protein kinase
B6R96_RS02695	COG2815	serine threonine protein kinase
B6R96_RS02705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B6R96_RS02735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6R96_RS02740	COG0693	protein deglycase activity
B6R96_RS02745	COG2356	endonuclease I
B6R96_RS02755	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B6R96_RS02765	COG2814	Major facilitator Superfamily
B6R96_RS02795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6R96_RS02800	COG0393	Putative heavy-metal-binding
B6R96_RS02805	COG2197	response regulator
B6R96_RS02815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6R96_RS02845	COG0702	epimerase
B6R96_RS02850	COG1733	regulation of RNA biosynthetic process
B6R96_RS02880	COG0483	inositol monophosphate 1-phosphatase activity
B6R96_RS02935	COG0789	Transcriptional regulator
B6R96_RS02965	COG0702	epimerase
B6R96_RS03065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6R96_RS03100	COG2909	trisaccharide binding
B6R96_RS03105	COG0539	negative regulation of cytoplasmic translation
B6R96_RS03120	COG1120	ATPase activity
B6R96_RS03125	COG0745	RESPONSE REGULATOR receiver
B6R96_RS03130	COG5002	protein histidine kinase activity
B6R96_RS03135	COG2409	Drug exporters of the RND superfamily
B6R96_RS03180	COG3284	Transcriptional regulator
B6R96_RS03185	COG1129	ABC transporter
B6R96_RS03190	COG1172	Belongs to the binding-protein-dependent transport system permease family
B6R96_RS03220	COG0277	FAD linked oxidase domain protein
B6R96_RS03235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6R96_RS03260	COG4221	oxidoreductase activity
B6R96_RS03305	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B6R96_RS03380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6R96_RS03385	COG1609	Transcriptional regulator
B6R96_RS03390	COG1051	belongs to the nudix hydrolase family
B6R96_RS03395	COG1136	(ABC) transporter
B6R96_RS03410	COG1136	(ABC) transporter
B6R96_RS03410	COG4591	ABC-type transport system involved in lipoprotein release permease component
B6R96_RS03415	COG0492	ferredoxin-NADP+ reductase activity
B6R96_RS03445	COG1131	(ABC) transporter
B6R96_RS03455	COG1595	DNA-templated transcription, initiation
B6R96_RS03465	COG4585	Histidine kinase
B6R96_RS03470	COG0142	geranyltranstransferase activity
B6R96_RS03510	COG0515	serine threonine protein kinase
B6R96_RS03520	COG1132	(ABC) transporter
B6R96_RS03525	COG1132	(ABC) transporter
B6R96_RS03545	COG3795	YCII-related domain
B6R96_RS03550	COG4941	Belongs to the sigma-70 factor family
B6R96_RS03560	COG1902	pentaerythritol trinitrate reductase activity
B6R96_RS03570	COG0148	phosphopyruvate hydratase activity
B6R96_RS03585	COG2326	polyphosphate kinase activity
B6R96_RS03590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6R96_RS03610	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6R96_RS03610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6R96_RS03620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6R96_RS03640	COG1309	transcriptional regulator
B6R96_RS03645	COG0596	Alpha beta hydrolase
B6R96_RS03650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6R96_RS03660	COG1428	Deoxynucleoside kinase
B6R96_RS03675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B6R96_RS03705	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B6R96_RS03725	COG2326	polyphosphate kinase activity
B6R96_RS03760	COG0596	Alpha beta hydrolase
B6R96_RS03780	COG4716	Myosin-crossreactive antigen
B6R96_RS03850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6R96_RS03870	COG3848	Pyruvate phosphate dikinase
B6R96_RS03870	COG0574	Belongs to the PEP-utilizing enzyme family
B6R96_RS03875	COG0783	Belongs to the Dps family
B6R96_RS03880	COG0671	phosphoesterase, PA-phosphatase related
B6R96_RS03905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6R96_RS03910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6R96_RS03945	COG0514	ATP-dependent DNA helicase (RecQ)
B6R96_RS03975	COG2274	protein secretion by the type I secretion system
B6R96_RS04005	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B6R96_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS04030	COG1271	oxidase subunit
B6R96_RS04045	COG3387	PFAM Glycoside hydrolase 15-related
B6R96_RS04125	COG0028	Belongs to the TPP enzyme family
B6R96_RS04130	COG0069	glutamate synthase activity
B6R96_RS04140	COG4221	oxidoreductase activity
B6R96_RS04160	COG0300	oxidoreductase activity
B6R96_RS04165	COG1764	response to oxidative stress
B6R96_RS04190	COG2271	Major facilitator Superfamily
B6R96_RS04200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6R96_RS04220	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6R96_RS04225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B6R96_RS04250	COG0640	Transcriptional regulator
B6R96_RS04255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B6R96_RS04325	COG0515	serine threonine protein kinase
B6R96_RS04335	COG4552	Acetyltransferase involved in intracellular survival and related
B6R96_RS04355	COG0598	Magnesium transport protein CorA
B6R96_RS04385	COG0596	Alpha beta hydrolase
B6R96_RS04390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B6R96_RS04420	COG2353	YceI-like domain
B6R96_RS04425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS04430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6R96_RS04435	COG4521	taurine ABC transporter
B6R96_RS04440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B6R96_RS04450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B6R96_RS04455	COG2201	protein-glutamate methylesterase activity
B6R96_RS04465	COG2197	response regulator
B6R96_RS04480	COG0784	Response regulator, receiver
B6R96_RS04485	COG4251	negative regulation of phosphorylation
B6R96_RS04505	COG2890	protein-(glutamine-N5) methyltransferase activity
B6R96_RS04555	COG1511	domain protein
B6R96_RS04585	COG4191	Histidine kinase
B6R96_RS04590	COG0667	Aldo Keto reductase
B6R96_RS04600	COG1881	PFAM PEBP family protein
B6R96_RS04645	COG1725	Transcriptional regulator
B6R96_RS04670	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B6R96_RS04675	COG0531	amino acid
B6R96_RS04705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B6R96_RS04710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B6R96_RS04715	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B6R96_RS04755	COG3547	Transposase (IS116 IS110 IS902 family)
B6R96_RS04810	COG1131	(ABC) transporter
B6R96_RS04815	COG4585	Histidine kinase
B6R96_RS04820	COG2197	response regulator
B6R96_RS04840	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6R96_RS04865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS04875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6R96_RS04880	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6R96_RS04910	COG3629	intracellular signal transduction
B6R96_RS04910	COG3903	Transcriptional regulator
B6R96_RS04915	COG2226	methyltransferase
B6R96_RS04935	COG1289	transmembrane transporter activity
B6R96_RS04960	COG0542	response to heat
B6R96_RS04975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B6R96_RS04980	COG0443	Heat shock 70 kDa protein
B6R96_RS05005	COG2813	Specifically methylates the guanine in position
B6R96_RS05030	COG4106	trans-aconitate 2-methyltransferase activity
B6R96_RS05050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B6R96_RS05110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B6R96_RS05130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B6R96_RS05150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6R96_RS05160	COG0183	Belongs to the thiolase family
B6R96_RS05165	COG1609	Transcriptional regulator
B6R96_RS05175	COG0596	Alpha beta hydrolase
B6R96_RS05185	COG4122	O-methyltransferase activity
B6R96_RS05200	COG3572	ergothioneine biosynthetic process
B6R96_RS05205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B6R96_RS05210	COG0121	glutamine amidotransferase
B6R96_RS05215	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B6R96_RS05235	COG3360	Dodecin
B6R96_RS05245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS05265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B6R96_RS05270	COG1053	succinate dehydrogenase
B6R96_RS05280	COG0583	DNA-binding transcription factor activity
B6R96_RS05290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6R96_RS05330	COG0726	polysaccharide deacetylase
B6R96_RS05335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6R96_RS05335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6R96_RS05365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6R96_RS05430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B6R96_RS05450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B6R96_RS05455	COG1737	Transcriptional regulator
B6R96_RS05470	COG1126	abc transporter atp-binding protein
B6R96_RS05475	COG0765	amino acid transport
B6R96_RS05505	COG1819	glycosyl
B6R96_RS05560	COG0513	Belongs to the DEAD box helicase family
B6R96_RS05565	COG1278	Cold shock
B6R96_RS05570	COG0596	Alpha beta hydrolase
B6R96_RS05620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS05630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS05645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6R96_RS05655	COG0165	Argininosuccinate lyase
B6R96_RS05665	COG2267	carboxylic ester hydrolase activity
B6R96_RS05675	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B6R96_RS05730	COG1595	DNA-templated transcription, initiation
B6R96_RS05745	COG3835	regulator
B6R96_RS05750	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B6R96_RS05755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6R96_RS05755	COG2080	2 iron, 2 sulfur cluster binding
B6R96_RS05770	COG0577	efflux transmembrane transporter activity
B6R96_RS05770	COG1136	(ABC) transporter
B6R96_RS05795	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS05905	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6R96_RS05905	COG1902	pentaerythritol trinitrate reductase activity
B6R96_RS05920	COG0395	ABC-type sugar transport system, permease component
B6R96_RS05925	COG1175	transmembrane transport
B6R96_RS05930	COG1653	transport
B6R96_RS05955	COG0589	response to stress
B6R96_RS05970	COG3345	alpha-galactosidase
B6R96_RS05980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B6R96_RS06000	COG3321	synthase
B6R96_RS06000	COG0604	alcohol dehydrogenase
B6R96_RS06005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS06005	COG3321	synthase
B6R96_RS06015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B6R96_RS06020	COG1819	glycosyl
B6R96_RS06035	COG3511	phospholipase C
B6R96_RS06055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6R96_RS06060	COG1024	Enoyl-CoA hydratase
B6R96_RS06070	COG1335	isochorismatase
B6R96_RS06080	COG1231	oxidoreductase activity
B6R96_RS06090	COG1132	(ABC) transporter
B6R96_RS06105	COG4608	Belongs to the ABC transporter superfamily
B6R96_RS06115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6R96_RS06125	COG0747	negative chemotaxis
B6R96_RS06130	COG2957	Belongs to the agmatine deiminase family
B6R96_RS06135	COG0804	urea catabolic process
B6R96_RS06140	COG0832	Belongs to the urease beta subunit family
B6R96_RS06140	COG0831	urea catabolic process
B6R96_RS06155	COG0515	serine threonine protein kinase
B6R96_RS06155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6R96_RS06185	COG0438	transferase activity, transferring glycosyl groups
B6R96_RS06190	COG2327	Polysaccharide pyruvyl transferase
B6R96_RS06200	COG0297	glycogen (starch) synthase activity
B6R96_RS06240	COG0346	lactoylglutathione lyase activity
B6R96_RS06245	COG1556	Lactate utilization protein
B6R96_RS06250	COG1139	Iron-sulfur cluster binding protein
B6R96_RS06255	COG0247	lactate metabolic process
B6R96_RS06265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6R96_RS06270	COG0583	DNA-binding transcription factor activity
B6R96_RS06290	COG3119	arylsulfatase activity
B6R96_RS06290	COG3119	arylsulfatase activity
B6R96_RS06295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B6R96_RS06305	COG2838	Isocitrate dehydrogenase
B6R96_RS06310	COG3152	Membrane
B6R96_RS06320	COG0598	Magnesium transport protein CorA
B6R96_RS06330	COG0583	DNA-binding transcription factor activity
B6R96_RS06355	COG2814	Major facilitator Superfamily
B6R96_RS06365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B6R96_RS06460	COG1657	PFAM Prenyltransferase squalene oxidase
B6R96_RS06470	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B6R96_RS06485	COG1562	ergosterol biosynthetic process
B6R96_RS06490	COG1134	teichoic acid transport
B6R96_RS06510	COG0371	Dehydrogenase
B6R96_RS06525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6R96_RS06530	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B6R96_RS06545	COG1024	Enoyl-CoA hydratase
B6R96_RS06555	COG4977	sequence-specific DNA binding
B6R96_RS06560	COG0488	(ABC) transporter
B6R96_RS06565	COG0300	oxidoreductase activity
B6R96_RS06580	COG2183	response to ionizing radiation
B6R96_RS06605	COG1022	Amp-dependent synthetase and ligase
B6R96_RS06610	COG0789	Transcriptional regulator
B6R96_RS06620	COG1024	Enoyl-CoA hydratase
B6R96_RS06620	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6R96_RS06625	COG0183	Belongs to the thiolase family
B6R96_RS06630	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS06635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS06640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B6R96_RS06650	COG3268	Saccharopine dehydrogenase
B6R96_RS06655	COG1515	deoxyribonuclease V activity
B6R96_RS06680	COG0488	(ABC) transporter
B6R96_RS06745	COG1793	dna ligase
B6R96_RS06765	COG0494	nUDIX hydrolase
B6R96_RS06780	COG1486	melibiose metabolic process
B6R96_RS06820	COG0515	serine threonine protein kinase
B6R96_RS06825	COG1288	antiporter activity
B6R96_RS06835	COG2197	response regulator
B6R96_RS06855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6R96_RS06875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6R96_RS06880	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B6R96_RS06920	COG0656	L-ascorbic acid biosynthetic process
B6R96_RS06930	COG2154	pterin-4-alpha-carbinolamine dehydratase
B6R96_RS06970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6R96_RS06980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6R96_RS07000	COG0531	amino acid
B6R96_RS07055	COG2226	methyltransferase
B6R96_RS07060	COG0457	Tetratricopeptide repeat
B6R96_RS07085	COG1733	regulation of RNA biosynthetic process
B6R96_RS07095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6R96_RS07100	COG2362	D-Aminopeptidase
B6R96_RS07130	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6R96_RS07140	COG0604	alcohol dehydrogenase
B6R96_RS07145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6R96_RS07145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6R96_RS07160	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS07165	COG0688	phosphatidylethanolamine metabolic process
B6R96_RS07180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6R96_RS07200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B6R96_RS07205	COG1929	Belongs to the glycerate kinase type-1 family
B6R96_RS07210	COG1335	isochorismatase
B6R96_RS07230	COG1448	Aminotransferase
B6R96_RS07245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B6R96_RS07255	COG0483	inositol monophosphate 1-phosphatase activity
B6R96_RS07265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6R96_RS07270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6R96_RS07300	COG0405	Gamma-glutamyltransferase
B6R96_RS07320	COG2205	protein histidine kinase activity
B6R96_RS07325	COG0745	RESPONSE REGULATOR receiver
B6R96_RS07350	COG1126	abc transporter atp-binding protein
B6R96_RS07375	COG1940	carbohydrate kinase activity
B6R96_RS07380	COG1129	ABC transporter
B6R96_RS07395	COG0673	inositol 2-dehydrogenase activity
B6R96_RS07430	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS07440	COG4266	Belongs to the allantoicase family
B6R96_RS07445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6R96_RS07450	COG1414	Transcriptional regulator
B6R96_RS07470	COG2197	response regulator
B6R96_RS07485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B6R96_RS07510	COG2233	PERMEase
B6R96_RS07525	COG2351	hydroxyisourate hydrolase activity
B6R96_RS07545	COG3622	Belongs to the hyi family
B6R96_RS07550	COG2084	Dehydrogenase
B6R96_RS07555	COG0753	catalase activity
B6R96_RS07565	COG3960	tartronate-semialdehyde synthase activity
B6R96_RS07575	COG0386	Belongs to the glutathione peroxidase family
B6R96_RS07580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6R96_RS07590	COG0598	Magnesium transport protein CorA
B6R96_RS07635	COG0515	serine threonine protein kinase
B6R96_RS07645	COG2197	response regulator
B6R96_RS07650	COG3851	Histidine kinase
B6R96_RS07670	COG0309	Hydrogenase expression formation protein (HypE)
B6R96_RS07680	COG0298	carbon dioxide binding
B6R96_RS07685	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B6R96_RS07690	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B6R96_RS07695	COG0375	protein maturation
B6R96_RS07735	COG1024	Enoyl-CoA hydratase
B6R96_RS07735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6R96_RS07745	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS07755	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS07785	COG1088	dTDP-glucose 4,6-dehydratase activity
B6R96_RS07810	COG0463	Glycosyl transferase, family 2
B6R96_RS07855	COG0463	Glycosyl transferase, family 2
B6R96_RS07905	COG2211	Major facilitator Superfamily
B6R96_RS07915	COG3629	intracellular signal transduction
B6R96_RS07915	COG3903	Transcriptional regulator
B6R96_RS07925	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS07935	COG3903	Transcriptional regulator
B6R96_RS07935	COG2197	response regulator
B6R96_RS07940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B6R96_RS07975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6R96_RS07985	COG3321	synthase
B6R96_RS07985	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS07985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS07985	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS07985	COG0300	oxidoreductase activity
B6R96_RS07990	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS07995	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS08000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6R96_RS08100	COG4552	Acetyltransferase involved in intracellular survival and related
B6R96_RS08130	COG2252	PERMEase
B6R96_RS08150	COG3835	regulator
B6R96_RS08160	COG1802	Transcriptional regulator
B6R96_RS08195	COG1404	Belongs to the peptidase S8 family
B6R96_RS08220	COG1162	GTPase activity
B6R96_RS08240	COG2226	methyltransferase
B6R96_RS08250	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS08260	COG0456	acetyltransferase
B6R96_RS08260	COG1846	Transcriptional regulator
B6R96_RS08265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6R96_RS08275	COG0175	sulfate reduction
B6R96_RS08280	COG0529	Catalyzes the synthesis of activated sulfate
B6R96_RS08300	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B6R96_RS08305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6R96_RS08315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B6R96_RS08375	COG0583	DNA-binding transcription factor activity
B6R96_RS08380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6R96_RS08425	COG3511	phospholipase C
B6R96_RS08470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6R96_RS08475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B6R96_RS08520	COG2326	polyphosphate kinase activity
B6R96_RS08555	COG1116	anion transmembrane transporter activity
B6R96_RS08570	COG3220	belongs to the UPF0276 family
B6R96_RS08580	COG0596	Alpha beta hydrolase
B6R96_RS08585	COG3253	May function as heme-dependent peroxidase
B6R96_RS08590	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B6R96_RS08600	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6R96_RS08610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B6R96_RS08625	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B6R96_RS08635	COG0183	Belongs to the thiolase family
B6R96_RS08640	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6R96_RS08640	COG1024	Enoyl-CoA hydratase
B6R96_RS08645	COG1316	TRANSCRIPTIONal
B6R96_RS08650	COG0531	amino acid
B6R96_RS08655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B6R96_RS08660	COG4214	carbohydrate transport
B6R96_RS08670	COG4213	ABC transporter substrate-binding protein
B6R96_RS08675	COG1940	carbohydrate kinase activity
B6R96_RS08685	COG1285	pathogenesis
B6R96_RS08695	COG0395	ABC-type sugar transport system, permease component
B6R96_RS08700	COG1175	transmembrane transport
B6R96_RS08705	COG1653	transport
B6R96_RS08710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B6R96_RS08725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6R96_RS08765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6R96_RS08770	COG4608	Belongs to the ABC transporter superfamily
B6R96_RS08785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6R96_RS08800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6R96_RS08810	COG3938	Belongs to the proline racemase family
B6R96_RS08830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6R96_RS08840	COG0006	proline dipeptidase activity
B6R96_RS08845	COG2205	protein histidine kinase activity
B6R96_RS08850	COG0745	RESPONSE REGULATOR receiver
B6R96_RS08895	COG1024	Enoyl-CoA hydratase
B6R96_RS08905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6R96_RS08920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B6R96_RS08930	COG2040	homocysteine
B6R96_RS08960	COG1799	cell septum assembly
B6R96_RS08980	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6R96_RS08985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS09005	COG0431	NADPH-dependent FMN reductase
B6R96_RS09040	COG0252	asparaginase activity
B6R96_RS09050	COG2409	Drug exporters of the RND superfamily
B6R96_RS09055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B6R96_RS09090	COG3321	synthase
B6R96_RS09090	COG0604	alcohol dehydrogenase
B6R96_RS09130	COG0644	oxidoreductase
B6R96_RS09135	COG2124	cytochrome p450
B6R96_RS09140	COG2124	cytochrome p450
B6R96_RS09210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6R96_RS09215	COG0531	amino acid
B6R96_RS09220	COG0569	domain protein
B6R96_RS09255	COG0756	dUTP diphosphatase activity
B6R96_RS09280	COG2205	protein histidine kinase activity
B6R96_RS09285	COG0745	RESPONSE REGULATOR receiver
B6R96_RS09300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B6R96_RS09345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6R96_RS09350	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B6R96_RS09395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6R96_RS09400	COG1435	thymidine kinase activity
B6R96_RS09420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6R96_RS09425	COG1802	Transcriptional regulator
B6R96_RS09440	COG0612	Peptidase, M16
B6R96_RS09445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6R96_RS09460	COG0372	Belongs to the citrate synthase family
B6R96_RS09470	COG3290	protein histidine kinase activity
B6R96_RS09475	COG4565	transcriptional regulatory protein
B6R96_RS09480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B6R96_RS09505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6R96_RS09550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B6R96_RS09575	COG0406	alpha-ribazole phosphatase activity
B6R96_RS09595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6R96_RS09600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B6R96_RS09605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6R96_RS09640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6R96_RS09650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6R96_RS09655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B6R96_RS09665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B6R96_RS09680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6R96_RS09700	COG1609	Transcriptional regulator
B6R96_RS09725	COG2205	protein histidine kinase activity
B6R96_RS09735	COG1126	abc transporter atp-binding protein
B6R96_RS09740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6R96_RS09745	COG0765	amino acid transport
B6R96_RS09750	COG0765	amino acid transport
B6R96_RS09775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B6R96_RS09790	COG2226	methyltransferase
B6R96_RS09825	COG1917	Cupin 2, conserved barrel domain protein
B6R96_RS09825	COG2207	Transcriptional regulator
B6R96_RS09830	COG1201	RNA secondary structure unwinding
B6R96_RS09835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6R96_RS09840	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS09850	COG1396	sequence-specific DNA binding
B6R96_RS09855	COG1546	Belongs to the CinA family
B6R96_RS09855	COG1058	Belongs to the CinA family
B6R96_RS09865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6R96_RS09875	COG1674	ftsk spoiiie
B6R96_RS09885	COG2205	protein histidine kinase activity
B6R96_RS09885	COG3437	response regulator, receiver
B6R96_RS09885	COG4999	Histidine kinase
B6R96_RS09885	COG3850	Histidine kinase
B6R96_RS09895	COG2208	phosphoserine phosphatase activity
B6R96_RS09895	COG2770	Histidine kinase
B6R96_RS09930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B6R96_RS09935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6R96_RS09940	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B6R96_RS09960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B6R96_RS09965	COG0612	Peptidase, M16
B6R96_RS09970	COG1185	polyribonucleotide nucleotidyltransferase activity
B6R96_RS09975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B6R96_RS09985	COG1674	ftsk spoiiie
B6R96_RS10005	COG1404	Belongs to the peptidase S8 family
B6R96_RS10025	COG0455	bacterial-type flagellum organization
B6R96_RS10040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6R96_RS10045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B6R96_RS10055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B6R96_RS10070	COG0779	Required for maturation of 30S ribosomal subunits
B6R96_RS10095	COG0330	HflC and HflK could
B6R96_RS10100	COG0442	prolyl-tRNA aminoacylation
B6R96_RS10115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B6R96_RS10120	COG0750	zinc metalloprotease
B6R96_RS10125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B6R96_RS10140	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS10145	COG2508	Transcriptional regulator
B6R96_RS10175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6R96_RS10180	COG1177	transmembrane transport
B6R96_RS10185	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6R96_RS10190	COG3842	ATPase activity
B6R96_RS10195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B6R96_RS10225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B6R96_RS10235	COG4585	Histidine kinase
B6R96_RS10240	COG2197	response regulator
B6R96_RS10260	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS10270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B6R96_RS10305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6R96_RS10315	COG3842	ATPase activity
B6R96_RS10330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B6R96_RS10340	COG0233	cytoplasmic translational termination
B6R96_RS10345	COG0528	UMP kinase activity
B6R96_RS10350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B6R96_RS10355	COG0052	Belongs to the universal ribosomal protein uS2 family
B6R96_RS10370	COG1191	sigma factor activity
B6R96_RS10425	COG1074	ATP-dependent DNA helicase activity
B6R96_RS10430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6R96_RS10460	COG1051	belongs to the nudix hydrolase family
B6R96_RS10465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B6R96_RS10505	COG0792	nuclease activity
B6R96_RS10520	COG0681	Belongs to the peptidase S26 family
B6R96_RS10525	COG0681	Belongs to the peptidase S26 family
B6R96_RS10540	COG0335	large ribosomal subunit rRNA binding
B6R96_RS10545	COG0336	Belongs to the RNA methyltransferase TrmD family
B6R96_RS10550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B6R96_RS10555	COG1837	Belongs to the UPF0109 family
B6R96_RS10560	COG0228	four-way junction DNA binding
B6R96_RS10570	COG0442	prolyl-tRNA aminoacylation
B6R96_RS10580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6R96_RS10590	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B6R96_RS10625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS10630	COG0477	Major facilitator Superfamily
B6R96_RS10635	COG1196	nuclear chromosome segregation
B6R96_RS10645	COG1254	Belongs to the acylphosphatase family
B6R96_RS10660	COG1733	regulation of RNA biosynthetic process
B6R96_RS10665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6R96_RS10670	COG0571	ribonuclease III activity
B6R96_RS10675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B6R96_RS10690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B6R96_RS10695	COG0742	ribosomal rna small subunit methyltransferase
B6R96_RS10705	COG1461	Dihydroxyacetone kinase
B6R96_RS10710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6R96_RS10715	COG0351	phosphomethylpyrimidine kinase
B6R96_RS10735	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6R96_RS10740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B6R96_RS10750	COG1920	GTP binding
B6R96_RS10755	COG0776	regulation of translation
B6R96_RS10765	COG0066	3-isopropylmalate dehydratase activity
B6R96_RS10770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6R96_RS10815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6R96_RS10820	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6R96_RS10830	COG5002	protein histidine kinase activity
B6R96_RS10835	COG2018	Roadblock/LC7 domain
B6R96_RS10855	COG2018	Roadblock/LC7 domain
B6R96_RS10875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6R96_RS10880	COG2353	YceI-like domain
B6R96_RS10890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6R96_RS10900	COG2957	Belongs to the agmatine deiminase family
B6R96_RS10905	COG0804	urea catabolic process
B6R96_RS10910	COG0831	urea catabolic process
B6R96_RS10910	COG0832	Belongs to the urease beta subunit family
B6R96_RS10920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6R96_RS10925	COG0473	3-isopropylmalate dehydrogenase activity
B6R96_RS10930	COG0583	DNA-binding transcription factor activity
B6R96_RS10935	COG2130	NADP-dependent
B6R96_RS10940	COG3511	phospholipase C
B6R96_RS10955	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS10960	COG0506	proline dehydrogenase activity
B6R96_RS10965	COG3835	regulator
B6R96_RS10975	COG0477	Major facilitator Superfamily
B6R96_RS10985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B6R96_RS10990	COG0440	acetolactate synthase activity
B6R96_RS11010	COG0667	Aldo Keto reductase
B6R96_RS11015	COG2133	pyrroloquinoline quinone binding
B6R96_RS11025	COG2197	response regulator
B6R96_RS11040	COG2409	Drug exporters of the RND superfamily
B6R96_RS11055	COG2318	DinB family
B6R96_RS11090	COG0515	serine threonine protein kinase
B6R96_RS11090	COG2815	serine threonine protein kinase
B6R96_RS11095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6R96_RS11105	COG0154	amidase activity
B6R96_RS11110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6R96_RS11120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6R96_RS11165	COG0482	sulfurtransferase activity
B6R96_RS11185	COG2860	membrane
B6R96_RS11190	COG4608	Belongs to the ABC transporter superfamily
B6R96_RS11195	COG0444	Belongs to the ABC transporter superfamily
B6R96_RS11205	COG0747	negative chemotaxis
B6R96_RS11210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6R96_RS11230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6R96_RS11235	COG0509	glycine decarboxylation via glycine cleavage system
B6R96_RS11240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6R96_RS11245	COG1760	l-serine dehydratase
B6R96_RS11335	COG0297	glycogen (starch) synthase activity
B6R96_RS11340	COG0489	protein tyrosine kinase activity
B6R96_RS11380	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B6R96_RS11385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6R96_RS11390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6R96_RS11405	COG0058	SHG alpha-glucan phosphorylase activity
B6R96_RS11410	COG0366	Alpha amylase catalytic
B6R96_RS11415	COG0366	Alpha amylase catalytic
B6R96_RS11445	COG0205	6-phosphofructokinase activity
B6R96_RS11450	COG0280	phosphate acetyltransferase
B6R96_RS11450	COG0857	belongs to the CobB CobQ family
B6R96_RS11455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B6R96_RS11495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6R96_RS11495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6R96_RS11580	COG0183	Belongs to the thiolase family
B6R96_RS11635	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B6R96_RS11650	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6R96_RS11680	COG2197	response regulator
B6R96_RS11695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B6R96_RS11700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B6R96_RS11705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B6R96_RS11710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B6R96_RS11715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6R96_RS11720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6R96_RS11725	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6R96_RS11745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6R96_RS11750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B6R96_RS11760	COG2890	protein-(glutamine-N5) methyltransferase activity
B6R96_RS11765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6R96_RS11770	COG0254	rRNA binding
B6R96_RS11775	COG1316	TRANSCRIPTIONal
B6R96_RS11785	COG0083	homoserine kinase activity
B6R96_RS11790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B6R96_RS11795	COG0460	homoserine dehydrogenase
B6R96_RS11800	COG0019	diaminopimelate decarboxylase activity
B6R96_RS11805	COG0018	arginyl-trna synthetase
B6R96_RS11805	COG0018	arginyl-trna synthetase
B6R96_RS11810	COG0745	RESPONSE REGULATOR receiver
B6R96_RS11915	COG1201	RNA secondary structure unwinding
B6R96_RS11920	COG3608	succinylglutamate desuccinylase aspartoacylase
B6R96_RS11920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B6R96_RS11935	COG1793	dna ligase
B6R96_RS11940	COG1793	dna ligase
B6R96_RS11940	COG3285	dna ligase
B6R96_RS11945	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B6R96_RS11965	COG2205	protein histidine kinase activity
B6R96_RS11975	COG1309	transcriptional regulator
B6R96_RS11995	COG0772	Belongs to the SEDS family
B6R96_RS12010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6R96_RS12015	COG1595	DNA-templated transcription, initiation
B6R96_RS12020	COG3103	Sh3 type 3 domain protein
B6R96_RS12020	COG0791	NLP P60 protein
B6R96_RS12020	COG1388	LysM domain
B6R96_RS12045	COG5002	protein histidine kinase activity
B6R96_RS12060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B6R96_RS12085	COG2897	thiosulfate sulfurtransferase activity
B6R96_RS12115	COG0745	RESPONSE REGULATOR receiver
B6R96_RS12120	COG2205	protein histidine kinase activity
B6R96_RS12125	COG0567	Dehydrogenase, E1 component
B6R96_RS12125	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6R96_RS12175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6R96_RS12215	COG4106	trans-aconitate 2-methyltransferase activity
B6R96_RS12220	COG1126	abc transporter atp-binding protein
B6R96_RS12225	COG0765	amino acid transport
B6R96_RS12235	COG0281	malic enzyme
B6R96_RS12240	COG0604	alcohol dehydrogenase
B6R96_RS12270	COG0583	DNA-binding transcription factor activity
B6R96_RS12295	COG0142	geranyltranstransferase activity
B6R96_RS12300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6R96_RS12305	COG1959	2 iron, 2 sulfur cluster binding
B6R96_RS12310	COG1017	nitric oxide dioxygenase activity
B6R96_RS12310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B6R96_RS12320	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B6R96_RS12365	COG1309	transcriptional regulator
B6R96_RS12370	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS12375	COG0363	glucosamine-6-phosphate deaminase activity
B6R96_RS12380	COG1472	Belongs to the glycosyl hydrolase 3 family
B6R96_RS12385	COG0395	ABC-type sugar transport system, permease component
B6R96_RS12390	COG1175	transmembrane transport
B6R96_RS12395	COG2182	Extracellular solute-binding protein
B6R96_RS12400	COG2188	Transcriptional regulator
B6R96_RS12405	COG1966	Carbon starvation protein
B6R96_RS12440	COG0242	peptide deformylase activity
B6R96_RS12455	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B6R96_RS12455	COG2199	diguanylate cyclase activity
B6R96_RS12460	COG5662	AntiSigma factor
B6R96_RS12465	COG1595	DNA-templated transcription, initiation
B6R96_RS12475	COG2135	peptidase activity
B6R96_RS12485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6R96_RS12495	COG2076	Multidrug Resistance protein
B6R96_RS12505	COG0483	inositol monophosphate 1-phosphatase activity
B6R96_RS12515	COG0753	catalase activity
B6R96_RS12535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6R96_RS12550	COG1615	UPF0182 protein
B6R96_RS12560	COG3480	Lon protease (S16) C-terminal proteolytic domain
B6R96_RS12615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B6R96_RS12655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6R96_RS12660	COG0210	DNA helicase
B6R96_RS12715	COG0601	transmembrane transport
B6R96_RS12720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6R96_RS12770	COG2267	carboxylic ester hydrolase activity
B6R96_RS12775	COG2095	MarC family integral membrane protein
B6R96_RS12795	COG0598	Magnesium transport protein CorA
B6R96_RS12830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6R96_RS12835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6R96_RS12845	COG1595	DNA-templated transcription, initiation
B6R96_RS12865	COG1024	Enoyl-CoA hydratase
B6R96_RS12870	COG0519	Catalyzes the synthesis of GMP from XMP
B6R96_RS12880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B6R96_RS12885	COG1611	Belongs to the LOG family
B6R96_RS12890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6R96_RS12925	COG2197	response regulator
B6R96_RS12930	COG4585	Histidine kinase
B6R96_RS12940	COG1131	(ABC) transporter
B6R96_RS12960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B6R96_RS12970	COG4608	Belongs to the ABC transporter superfamily
B6R96_RS12975	COG0444	Belongs to the ABC transporter superfamily
B6R96_RS12980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6R96_RS12985	COG0601	transmembrane transport
B6R96_RS12990	COG4166	transmembrane transport
B6R96_RS13005	COG4608	Belongs to the ABC transporter superfamily
B6R96_RS13015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6R96_RS13020	COG0601	transmembrane transport
B6R96_RS13025	COG4166	transmembrane transport
B6R96_RS13065	COG1842	Phage shock protein A
B6R96_RS13110	COG2224	Isocitrate lyase
B6R96_RS13115	COG0697	spore germination
B6R96_RS13155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B6R96_RS13165	COG0012	GTP binding
B6R96_RS13180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B6R96_RS13190	COG1570	exodeoxyribonuclease VII activity
B6R96_RS13195	COG1722	exodeoxyribonuclease VII activity
B6R96_RS13200	COG0778	Nitroreductase
B6R96_RS13235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B6R96_RS13235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B6R96_RS13270	COG0114	fumarate hydratase activity
B6R96_RS13285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6R96_RS13305	COG1136	(ABC) transporter
B6R96_RS13320	COG0450	alkyl hydroperoxide reductase
B6R96_RS13325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6R96_RS13350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B6R96_RS13355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6R96_RS13360	COG0667	Aldo Keto reductase
B6R96_RS13425	COG1309	transcriptional regulator
B6R96_RS13435	COG2885	chlorophyll binding
B6R96_RS13485	COG2894	cell division
B6R96_RS13515	COG1414	Transcriptional regulator
B6R96_RS13525	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B6R96_RS13575	COG0436	Aminotransferase
B6R96_RS13600	COG3853	Toxic anion resistance protein (TelA)
B6R96_RS13615	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B6R96_RS13630	COG0463	Glycosyl transferase, family 2
B6R96_RS13665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B6R96_RS13675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6R96_RS13690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6R96_RS13700	COG1595	DNA-templated transcription, initiation
B6R96_RS13730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6R96_RS13735	COG3119	arylsulfatase activity
B6R96_RS13740	COG1064	alcohol dehydrogenase
B6R96_RS13750	COG0456	acetyltransferase
B6R96_RS13755	COG1376	ErfK ybiS ycfS ynhG family protein
B6R96_RS13770	COG2986	histidine ammonia-lyase
B6R96_RS13780	COG1024	Enoyl-CoA hydratase
B6R96_RS13795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6R96_RS13805	COG0424	maF-like protein
B6R96_RS13815	COG2226	methyltransferase
B6R96_RS13830	COG1819	glycosyl
B6R96_RS13835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6R96_RS13840	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS13855	COG0515	serine threonine protein kinase
B6R96_RS13860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6R96_RS13870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6R96_RS13915	COG4770	biotin carboxylase activity
B6R96_RS13940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6R96_RS13950	COG2205	protein histidine kinase activity
B6R96_RS13955	COG0745	RESPONSE REGULATOR receiver
B6R96_RS13960	COG1595	DNA-templated transcription, initiation
B6R96_RS13975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B6R96_RS14000	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS14005	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS14050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B6R96_RS14075	COG0583	DNA-binding transcription factor activity
B6R96_RS14080	COG2814	Major facilitator Superfamily
B6R96_RS14125	COG1079	Belongs to the binding-protein-dependent transport system permease family
B6R96_RS14130	COG4603	Belongs to the binding-protein-dependent transport system permease family
B6R96_RS14135	COG3845	ABC transporter
B6R96_RS14140	COG1744	ABC transporter substrate-binding protein PnrA-like
B6R96_RS14145	COG1473	amidohydrolase
B6R96_RS14145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6R96_RS14155	COG2089	acid synthase
B6R96_RS14165	COG1216	Glycosyl transferase, family 2
B6R96_RS14180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6R96_RS14180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6R96_RS14195	COG1595	DNA-templated transcription, initiation
B6R96_RS14205	COG2009	succinate dehydrogenase
B6R96_RS14215	COG1053	succinate dehydrogenase
B6R96_RS14220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B6R96_RS14240	COG0596	Alpha beta hydrolase
B6R96_RS14255	COG1309	transcriptional regulator
B6R96_RS14265	COG1408	metallophosphoesterase
B6R96_RS14275	COG1686	Belongs to the peptidase S11 family
B6R96_RS14295	COG1295	ribonuclease BN
B6R96_RS14305	COG0180	Tryptophanyl-tRNA synthetase
B6R96_RS14310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6R96_RS14315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6R96_RS14320	COG0754	glutathionylspermidine amidase activity
B6R96_RS14335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6R96_RS14340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6R96_RS14360	COG0039	L-malate dehydrogenase activity
B6R96_RS14380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6R96_RS14390	COG0138	bifunctional purine biosynthesis protein purh
B6R96_RS14420	COG0045	succinate-CoA ligase (ADP-forming) activity
B6R96_RS14425	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B6R96_RS14435	COG0714	Associated with various cellular activities
B6R96_RS14450	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6R96_RS14450	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6R96_RS14470	COG0640	Transcriptional regulator
B6R96_RS14490	COG2197	response regulator
B6R96_RS14525	COG0519	Catalyzes the synthesis of GMP from XMP
B6R96_RS14525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6R96_RS14545	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS14550	COG0515	serine threonine protein kinase
B6R96_RS14560	COG0515	serine threonine protein kinase
B6R96_RS14565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B6R96_RS14580	COG0516	GMP reductase activity
B6R96_RS14590	COG1595	DNA-templated transcription, initiation
B6R96_RS14605	COG0583	DNA-binding transcription factor activity
B6R96_RS14615	COG4221	oxidoreductase activity
B6R96_RS14625	COG0459	protein refolding
B6R96_RS14630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B6R96_RS14640	COG2205	protein histidine kinase activity
B6R96_RS14645	COG1316	TRANSCRIPTIONal
B6R96_RS14670	COG0726	polysaccharide deacetylase
B6R96_RS14675	COG0726	polysaccharide deacetylase
B6R96_RS14690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6R96_RS14710	COG0802	atpase or kinase
B6R96_RS14720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B6R96_RS14730	COG0736	holo-[acyl-carrier-protein] synthase activity
B6R96_RS14735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6R96_RS14745	COG1072	(Pantothenic acid kinase))
B6R96_RS14755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6R96_RS14760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6R96_RS14765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B6R96_RS14775	COG0488	(ABC) transporter
B6R96_RS14780	COG0101	tRNA pseudouridine synthase activity
B6R96_RS14785	COG0203	ribosomal protein L17
B6R96_RS14790	COG0202	RNA polymerase activity
B6R96_RS14795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6R96_RS14800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6R96_RS14805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6R96_RS14810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B6R96_RS14820	COG0563	adenylate kinase activity
B6R96_RS14825	COG0201	protein transport
B6R96_RS14830	COG0200	Binds to the 23S rRNA
B6R96_RS14835	COG1841	ribosomal large subunit assembly
B6R96_RS14840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6R96_RS14845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B6R96_RS14850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6R96_RS14855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6R96_RS14865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6R96_RS14870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6R96_RS14875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6R96_RS14880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6R96_RS14885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B6R96_RS14890	COG0255	Belongs to the universal ribosomal protein uL29 family
B6R96_RS14895	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B6R96_RS14900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6R96_RS14905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6R96_RS14910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B6R96_RS14915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6R96_RS14920	COG0089	rRNA binding
B6R96_RS14925	COG0088	Forms part of the polypeptide exit tunnel
B6R96_RS14930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6R96_RS14935	COG0051	transcription antitermination factor activity, RNA binding
B6R96_RS14965	COG1216	Glycosyl transferase, family 2
B6R96_RS14995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B6R96_RS15000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6R96_RS15005	COG0049	tRNA binding
B6R96_RS15010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B6R96_RS15020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6R96_RS15025	COG0085	RNA polymerase activity
B6R96_RS15035	COG0222	ribosome binding
B6R96_RS15040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B6R96_RS15055	COG0081	regulation of translation
B6R96_RS15060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6R96_RS15070	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6R96_RS15080	COG0436	Aminotransferase
B6R96_RS15085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B6R96_RS15095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B6R96_RS15105	COG0477	Major facilitator Superfamily
B6R96_RS15120	COG2030	dehydratase
B6R96_RS15125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6R96_RS15145	COG0702	epimerase
B6R96_RS15175	COG1666	GTP binding
B6R96_RS15180	COG0659	secondary active sulfate transmembrane transporter activity
B6R96_RS15195	COG3304	Inner membrane component domain
B6R96_RS15200	COG0501	Belongs to the peptidase M48B family
B6R96_RS15205	COG1007	ATP synthesis coupled electron transport
B6R96_RS15215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6R96_RS15220	COG0713	ATP synthesis coupled electron transport
B6R96_RS15225	COG0839	Belongs to the complex I subunit 6 family
B6R96_RS15230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6R96_RS15235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B6R96_RS15240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6R96_RS15245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6R96_RS15250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6R96_RS15270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B6R96_RS15270	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6R96_RS15275	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6R96_RS15300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B6R96_RS15305	COG0142	geranyltranstransferase activity
B6R96_RS15310	COG3104	oligopeptide transport
B6R96_RS15320	COG0561	phosphatase activity
B6R96_RS15330	COG2188	Transcriptional regulator
B6R96_RS15345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6R96_RS15355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6R96_RS15370	COG1007	ATP synthesis coupled electron transport
B6R96_RS15380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6R96_RS15385	COG0713	ATP synthesis coupled electron transport
B6R96_RS15390	COG0839	Belongs to the complex I subunit 6 family
B6R96_RS15395	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6R96_RS15400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B6R96_RS15405	COG1034	ATP synthesis coupled electron transport
B6R96_RS15410	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B6R96_RS15420	COG0649	NAD binding
B6R96_RS15425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6R96_RS15430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6R96_RS15465	COG1136	(ABC) transporter
B6R96_RS15465	COG0577	efflux transmembrane transporter activity
B6R96_RS15470	COG0577	efflux transmembrane transporter activity
B6R96_RS15495	COG3409	Peptidoglycan-binding domain 1 protein
B6R96_RS15505	COG2066	Belongs to the glutaminase family
B6R96_RS15510	COG2226	methyltransferase
B6R96_RS15520	COG2197	response regulator
B6R96_RS15530	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B6R96_RS15540	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B6R96_RS15545	COG1278	Cold shock
B6R96_RS15610	COG1301	dicarboxylic acid transport
B6R96_RS15625	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B6R96_RS15635	COG0163	prenyltransferase activity
B6R96_RS15645	COG0109	protoheme IX farnesyltransferase activity
B6R96_RS15655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B6R96_RS15670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6R96_RS15680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B6R96_RS15685	COG1333	cytochrome c biogenesis protein
B6R96_RS15690	COG0785	Cytochrome C biogenesis protein
B6R96_RS15705	COG0406	alpha-ribazole phosphatase activity
B6R96_RS15710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6R96_RS15730	COG2197	response regulator
B6R96_RS15735	COG4946	Tricorn protease homolog
B6R96_RS15735	COG0793	Belongs to the peptidase S41A family
B6R96_RS15745	COG0464	growth
B6R96_RS15825	COG0604	alcohol dehydrogenase
B6R96_RS15825	COG3321	synthase
B6R96_RS15825	COG4221	oxidoreductase activity
B6R96_RS15825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS15830	COG1733	regulation of RNA biosynthetic process
B6R96_RS15850	COG0726	polysaccharide deacetylase
B6R96_RS15860	COG1690	Belongs to the RtcB family
B6R96_RS15880	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B6R96_RS15885	COG0018	arginyl-trna synthetase
B6R96_RS15990	COG0113	porphobilinogen synthase activity
B6R96_RS16000	COG4977	sequence-specific DNA binding
B6R96_RS16005	COG0477	Major facilitator Superfamily
B6R96_RS16010	COG1648	precorrin-2 dehydrogenase activity
B6R96_RS16010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6R96_RS16015	COG0181	hydroxymethylbilane synthase activity
B6R96_RS16020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B6R96_RS16025	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B6R96_RS16075	COG0123	including yeast histone deacetylase and acetoin utilization protein
B6R96_RS16085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6R96_RS16110	COG0180	Tryptophanyl-tRNA synthetase
B6R96_RS16115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B6R96_RS16125	COG1129	ABC transporter
B6R96_RS16125	COG0842	Transport permease protein
B6R96_RS16135	COG4991	sh3 domain protein
B6R96_RS16140	COG0515	serine threonine protein kinase
B6R96_RS16140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6R96_RS16145	COG0129	dihydroxy-acid dehydratase activity
B6R96_RS16155	COG1082	Xylose isomerase domain protein TIM barrel
B6R96_RS16165	COG0248	Ppx GppA phosphatase
B6R96_RS16185	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B6R96_RS16195	COG0671	phosphoesterase, PA-phosphatase related
B6R96_RS16200	COG1194	a g-specific adenine glycosylase
B6R96_RS16205	COG1595	DNA-templated transcription, initiation
B6R96_RS16215	COG0745	RESPONSE REGULATOR receiver
B6R96_RS16220	COG2205	protein histidine kinase activity
B6R96_RS16230	COG0739	heme binding
B6R96_RS16255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B6R96_RS16285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B6R96_RS16290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6R96_RS16300	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B6R96_RS16310	COG0640	Transcriptional regulator
B6R96_RS16345	COG0649	NAD binding
B6R96_RS16365	COG1732	Glycine betaine
B6R96_RS16375	COG1174	glycine betaine transport
B6R96_RS16390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6R96_RS16390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6R96_RS16405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B6R96_RS16410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B6R96_RS16425	COG0302	gtp cyclohydrolase
B6R96_RS16435	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B6R96_RS16440	COG0037	tRNA processing
B6R96_RS16450	COG2027	D-alanyl-D-alanine carboxypeptidase
B6R96_RS16455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B6R96_RS16465	COG0586	Pfam SNARE associated Golgi protein
B6R96_RS16470	COG0789	Transcriptional regulator
B6R96_RS16490	COG2318	DinB family
B6R96_RS16495	COG0768	penicillin binding
B6R96_RS16500	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS16525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6R96_RS16535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6R96_RS16535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6R96_RS16580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B6R96_RS16585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6R96_RS16590	COG1754	DNA topoisomerase type I activity
B6R96_RS16590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6R96_RS16600	COG2890	protein-(glutamine-N5) methyltransferase activity
B6R96_RS16610	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B6R96_RS16620	COG1366	Belongs to the anti-sigma-factor antagonist family
B6R96_RS16625	COG1111	helicase
B6R96_RS16625	COG1205	dead DEAH box helicase
B6R96_RS16685	COG0659	secondary active sulfate transmembrane transporter activity
B6R96_RS16695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6R96_RS16700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B6R96_RS16710	COG2267	carboxylic ester hydrolase activity
B6R96_RS16745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6R96_RS16765	COG0003	Pfam Anion-transporting ATPase
B6R96_RS16780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B6R96_RS16790	COG1408	metallophosphoesterase
B6R96_RS16820	COG0402	S-adenosylhomocysteine deaminase activity
B6R96_RS16840	COG1595	DNA-templated transcription, initiation
B6R96_RS16860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B6R96_RS16865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B6R96_RS16885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B6R96_RS16890	COG0693	protein deglycase activity
B6R96_RS16900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6R96_RS16900	COG0515	serine threonine protein kinase
B6R96_RS16925	COG4585	Histidine kinase
B6R96_RS16930	COG2197	response regulator
B6R96_RS16935	COG4585	Histidine kinase
B6R96_RS16940	COG2197	response regulator
B6R96_RS16950	COG3559	Exporter of polyketide antibiotics
B6R96_RS16955	COG1131	(ABC) transporter
B6R96_RS16970	COG0346	lactoylglutathione lyase activity
B6R96_RS16975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6R96_RS16990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6R96_RS17010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6R96_RS17040	COG0191	fructose-bisphosphate aldolase activity
B6R96_RS17045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6R96_RS17060	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B6R96_RS17090	COG0542	response to heat
B6R96_RS17115	COG0789	Transcriptional regulator
B6R96_RS17120	COG0484	heat shock protein binding
B6R96_RS17125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B6R96_RS17130	COG0443	Heat shock 70 kDa protein
B6R96_RS17140	COG0247	lactate metabolic process
B6R96_RS17140	COG2181	nitrate reductase activity
B6R96_RS17160	COG0717	Belongs to the dCTP deaminase family
B6R96_RS17220	COG1595	DNA-templated transcription, initiation
B6R96_RS17335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6R96_RS17345	COG0277	FAD linked oxidase domain protein
B6R96_RS17375	COG1278	Cold shock
B6R96_RS17470	COG1289	transmembrane transporter activity
B6R96_RS17480	COG2205	protein histidine kinase activity
B6R96_RS17495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B6R96_RS17525	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS17535	COG1362	aminopeptidase activity
B6R96_RS17580	COG2271	Major facilitator Superfamily
B6R96_RS17610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6R96_RS17640	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6R96_RS17645	COG0022	dehydrogenase e1 component
B6R96_RS17665	COG0515	serine threonine protein kinase
B6R96_RS17670	COG0515	serine threonine protein kinase
B6R96_RS17685	COG1136	(ABC) transporter
B6R96_RS17685	COG4591	ABC-type transport system involved in lipoprotein release permease component
B6R96_RS17700	COG0746	molybdenum cofactor guanylyltransferase activity
B6R96_RS17710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6R96_RS17715	COG3321	synthase
B6R96_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS17715	COG0604	alcohol dehydrogenase
B6R96_RS17735	COG1522	sequence-specific DNA binding
B6R96_RS17740	COG1309	transcriptional regulator
B6R96_RS17745	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6R96_RS17780	COG3396	Phenylacetate-CoA oxygenase
B6R96_RS17785	COG3460	Phenylacetate-CoA oxygenase
B6R96_RS17790	COG3396	Phenylacetate-CoA oxygenase
B6R96_RS17795	COG2151	metal-sulfur cluster biosynthetic enzyme
B6R96_RS17800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B6R96_RS17825	COG2197	response regulator
B6R96_RS17830	COG4585	Histidine kinase
B6R96_RS17840	COG1716	ATPase activity
B6R96_RS17845	COG1716	ATPase activity
B6R96_RS17860	COG0768	penicillin binding
B6R96_RS17870	COG0515	serine threonine protein kinase
B6R96_RS17875	COG3764	Sortase (surface protein transpeptidase)
B6R96_RS17880	COG3764	Sortase (surface protein transpeptidase)
B6R96_RS17890	COG3764	Sortase (surface protein transpeptidase)
B6R96_RS17905	COG0457	Tetratricopeptide repeat
B6R96_RS17905	COG0705	Rhomboid family
B6R96_RS17935	COG3903	Transcriptional regulator
B6R96_RS17935	COG3629	intracellular signal transduction
B6R96_RS17975	COG1834	amidinotransferase
B6R96_RS17980	COG0151	Belongs to the GarS family
B6R96_RS17990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6R96_RS17990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6R96_RS18005	COG1834	amidinotransferase
B6R96_RS18010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6R96_RS18025	COG0300	oxidoreductase activity
B6R96_RS18025	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS18025	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS18025	COG3321	synthase
B6R96_RS18025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS18030	COG0640	Transcriptional regulator
B6R96_RS18070	COG0515	serine threonine protein kinase
B6R96_RS18095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6R96_RS18105	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B6R96_RS18110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6R96_RS18115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B6R96_RS18120	COG0592	DNA-directed DNA polymerase activity
B6R96_RS18130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B6R96_RS18135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B6R96_RS18140	COG0594	ribonuclease P activity
B6R96_RS18145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B6R96_RS18150	COG0706	membrane insertase activity
B6R96_RS18160	COG0357	Ribosomal RNA small subunit methyltransferase G
B6R96_RS18165	COG1192	Involved in chromosome partitioning
B6R96_RS18180	COG3118	belongs to the thioredoxin family
B6R96_RS18185	COG0492	ferredoxin-NADP+ reductase activity
B6R96_RS18195	COG1595	DNA-templated transcription, initiation
B6R96_RS18200	COG0515	serine threonine protein kinase
B6R96_RS18200	COG2815	serine threonine protein kinase
B6R96_RS18215	COG0617	tRNA 3'-terminal CCA addition
B6R96_RS18225	COG1260	myo-inositol-1-phosphate synthase
B6R96_RS18235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6R96_RS18260	COG0360	Binds together with S18 to 16S ribosomal RNA
B6R96_RS18265	COG0629	single-stranded DNA binding
B6R96_RS18270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B6R96_RS18275	COG0359	binds to the 23S rRNA
B6R96_RS18280	COG0534	Mate efflux family protein
B6R96_RS18285	COG0305	Participates in initiation and elongation during chromosome replication
B6R96_RS18320	COG0494	nUDIX hydrolase
B6R96_RS18330	COG0626	cystathionine gamma-synthase activity
B6R96_RS18335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B6R96_RS18340	COG1950	PFAM Membrane protein of
B6R96_RS18345	COG0662	Cupin 2, conserved barrel domain protein
B6R96_RS18370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B6R96_RS18385	COG1609	Transcriptional regulator
B6R96_RS18390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6R96_RS18400	COG1271	oxidase subunit
B6R96_RS18405	COG1294	oxidase, subunit
B6R96_RS18410	COG4988	ABC transporter
B6R96_RS18420	COG0561	phosphatase activity
B6R96_RS18435	COG0326	Molecular chaperone. Has ATPase activity
B6R96_RS18440	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
B6R96_RS18445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6R96_RS18450	COG0789	Transcriptional regulator
B6R96_RS18470	COG1131	(ABC) transporter
B6R96_RS18495	COG2197	response regulator
B6R96_RS18510	COG0561	phosphatase activity
B6R96_RS18515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6R96_RS18525	COG2837	iron assimilation
B6R96_RS18530	COG2372	response to copper ion
B6R96_RS18540	COG1999	signal sequence binding
B6R96_RS18560	COG0006	proline dipeptidase activity
B6R96_RS18580	COG0653	protein targeting
B6R96_RS18595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6R96_RS18610	COG2855	membrane
B6R96_RS18640	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS18650	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS18665	COG1595	DNA-templated transcription, initiation
B6R96_RS18670	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS18730	COG0745	RESPONSE REGULATOR receiver
B6R96_RS18735	COG2205	protein histidine kinase activity
B6R96_RS18755	COG0477	Major facilitator Superfamily
B6R96_RS18760	COG1846	Transcriptional regulator
B6R96_RS18775	COG1191	sigma factor activity
B6R96_RS18815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6R96_RS18830	COG0433	COG0433 Predicted ATPase
B6R96_RS18875	COG0151	Belongs to the GarS family
B6R96_RS18890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6R96_RS18900	COG2197	response regulator
B6R96_RS18905	COG3850	Histidine kinase
B6R96_RS18915	COG1131	(ABC) transporter
B6R96_RS18935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6R96_RS18940	COG0047	phosphoribosylformylglycinamidine synthase activity
B6R96_RS18945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6R96_RS18960	COG3119	arylsulfatase activity
B6R96_RS18970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6R96_RS19000	COG1643	Atp-dependent helicase
B6R96_RS19015	COG0785	Cytochrome C biogenesis protein
B6R96_RS19040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6R96_RS19045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6R96_RS19055	COG0513	Belongs to the DEAD box helicase family
B6R96_RS19080	COG1196	nuclear chromosome segregation
B6R96_RS19080	COG0741	lytic transglycosylase activity
B6R96_RS19080	COG0739	heme binding
B6R96_RS19090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B6R96_RS19095	COG0579	oxidoreductase
B6R96_RS19135	COG1252	NADH dehydrogenase
B6R96_RS19260	COG0596	Alpha beta hydrolase
B6R96_RS19265	COG1357	PFAM Pentapeptide repeats (8 copies)
B6R96_RS19270	COG1280	lysine exporter protein (LysE YggA)
B6R96_RS19285	COG0741	lytic transglycosylase activity
B6R96_RS19285	COG0739	heme binding
B6R96_RS19285	COG1196	nuclear chromosome segregation
B6R96_RS19290	COG0671	phosphoesterase, PA-phosphatase related
B6R96_RS19310	COG1937	Protein conserved in bacteria
B6R96_RS19320	COG0306	phosphate transporter
B6R96_RS19350	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B6R96_RS19355	COG0456	acetyltransferase
B6R96_RS19360	COG0737	Belongs to the 5'-nucleotidase family
B6R96_RS19365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B6R96_RS19375	COG0823	Involved in the tonB-independent uptake of proteins
B6R96_RS19385	COG0745	RESPONSE REGULATOR receiver
B6R96_RS19390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6R96_RS19400	COG1609	Transcriptional regulator
B6R96_RS19405	COG0745	RESPONSE REGULATOR receiver
B6R96_RS19430	COG2897	thiosulfate sulfurtransferase activity
B6R96_RS19460	COG3485	protocatechuate 3,4-dioxygenase
B6R96_RS19465	COG0735	belongs to the Fur family
B6R96_RS19475	COG1490	D-aminoacyl-tRNA deacylase activity
B6R96_RS19485	COG4552	Acetyltransferase involved in intracellular survival and related
B6R96_RS19490	COG2890	protein-(glutamine-N5) methyltransferase activity
B6R96_RS19530	COG0438	transferase activity, transferring glycosyl groups
B6R96_RS19545	COG0588	phosphoglycerate mutase activity
B6R96_RS19560	COG5002	protein histidine kinase activity
B6R96_RS19580	COG1329	Transcriptional regulator
B6R96_RS19585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B6R96_RS19590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B6R96_RS19595	COG0215	cysteine-tRNA ligase activity
B6R96_RS19600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6R96_RS19610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6R96_RS19620	COG3842	ATPase activity
B6R96_RS19630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6R96_RS19630	COG0723	plastoquinol--plastocyanin reductase activity
B6R96_RS19665	COG2197	response regulator
B6R96_RS19695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6R96_RS19720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B6R96_RS19725	COG1940	carbohydrate kinase activity
B6R96_RS19730	COG2182	Extracellular solute-binding protein
B6R96_RS19740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6R96_RS19740	COG0561	phosphatase activity
B6R96_RS19750	COG0463	Glycosyl transferase, family 2
B6R96_RS19775	COG0135	phosphoribosylanthranilate isomerase activity
B6R96_RS19830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B6R96_RS19835	COG1737	Transcriptional regulator
B6R96_RS19850	COG2207	Transcriptional regulator
B6R96_RS19850	COG3708	Transcriptional regulator
B6R96_RS19875	COG3973	AAA domain
B6R96_RS19890	COG1061	Type III restriction enzyme res subunit
B6R96_RS19925	COG1278	Cold shock
B6R96_RS19930	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B6R96_RS19935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B6R96_RS19945	COG2814	Major facilitator Superfamily
B6R96_RS19965	COG2268	Band 7 protein
B6R96_RS19985	COG0667	Aldo Keto reductase
B6R96_RS20010	COG2252	PERMEase
B6R96_RS20020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6R96_RS20030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6R96_RS20055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B6R96_RS20060	COG0277	FAD linked oxidase domain protein
B6R96_RS20060	COG0247	lactate metabolic process
B6R96_RS20090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6R96_RS20120	COG0259	pyridoxamine-phosphate oxidase activity
B6R96_RS20130	COG4821	SIS domain
B6R96_RS20155	COG1131	(ABC) transporter
B6R96_RS20215	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS20225	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS20230	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS20265	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS20275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B6R96_RS20290	COG1024	Enoyl-CoA hydratase
B6R96_RS20300	COG2072	flavoprotein involved in K transport
B6R96_RS20315	COG0259	pyridoxamine-phosphate oxidase activity
B6R96_RS20325	COG0183	Belongs to the thiolase family
B6R96_RS20330	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS20350	COG0515	serine threonine protein kinase
B6R96_RS20350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6R96_RS20385	COG1024	Enoyl-CoA hydratase
B6R96_RS20455	COG0494	nUDIX hydrolase
B6R96_RS20460	COG1136	(ABC) transporter
B6R96_RS20460	COG0577	efflux transmembrane transporter activity
B6R96_RS20465	COG0577	efflux transmembrane transporter activity
B6R96_RS20465	COG1136	(ABC) transporter
B6R96_RS20480	COG0745	RESPONSE REGULATOR receiver
B6R96_RS20485	COG2205	protein histidine kinase activity
B6R96_RS20530	COG4335	DNA alkylation repair
B6R96_RS20590	COG2365	Tyrosine phosphatase family
B6R96_RS20595	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B6R96_RS20655	COG2205	protein histidine kinase activity
B6R96_RS20680	COG1136	(ABC) transporter
B6R96_RS20680	COG0577	efflux transmembrane transporter activity
B6R96_RS20685	COG1136	(ABC) transporter
B6R96_RS20690	COG2205	protein histidine kinase activity
B6R96_RS20695	COG0745	RESPONSE REGULATOR receiver
B6R96_RS20700	COG3629	intracellular signal transduction
B6R96_RS20700	COG3903	Transcriptional regulator
B6R96_RS20705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6R96_RS20720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6R96_RS20730	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS20730	COG0604	alcohol dehydrogenase
B6R96_RS20730	COG3321	synthase
B6R96_RS20740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6R96_RS20750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6R96_RS20755	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS20780	COG0477	Major facilitator Superfamily
B6R96_RS20825	COG3384	dioxygenase
B6R96_RS20840	COG0477	Major facilitator Superfamily
B6R96_RS20845	COG1349	DNA-binding transcription factor activity
B6R96_RS20910	COG0438	transferase activity, transferring glycosyl groups
B6R96_RS20915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6R96_RS20935	COG0438	transferase activity, transferring glycosyl groups
B6R96_RS20960	COG0492	ferredoxin-NADP+ reductase activity
B6R96_RS21025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B6R96_RS21050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6R96_RS21055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6R96_RS21065	COG0315	cyclic pyranopterin monophosphate synthase activity
B6R96_RS21070	COG0315	cyclic pyranopterin monophosphate synthase activity
B6R96_RS21070	COG0521	Mo-molybdopterin cofactor biosynthetic process
B6R96_RS21075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6R96_RS21110	COG0708	Exodeoxyribonuclease III
B6R96_RS21120	COG2072	flavoprotein involved in K transport
B6R96_RS21125	COG2267	carboxylic ester hydrolase activity
B6R96_RS21130	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS21135	COG4946	Tricorn protease homolog
B6R96_RS21135	COG0793	Belongs to the peptidase S41A family
B6R96_RS21145	COG2409	Drug exporters of the RND superfamily
B6R96_RS21155	COG0310	cobalt ion transport
B6R96_RS21165	COG1122	ATPase activity
B6R96_RS21170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6R96_RS21175	COG0442	prolyl-tRNA aminoacylation
B6R96_RS21210	COG0084	hydrolase, TatD family'
B6R96_RS21215	COG3584	3D domain protein
B6R96_RS21215	COG3583	domain protein
B6R96_RS21220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6R96_RS21225	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B6R96_RS21235	COG0488	(ABC) transporter
B6R96_RS21260	COG2197	response regulator
B6R96_RS21265	COG1846	Transcriptional regulator
B6R96_RS21270	COG4106	trans-aconitate 2-methyltransferase activity
B6R96_RS21280	COG1309	transcriptional regulator
B6R96_RS21290	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B6R96_RS21295	COG0193	aminoacyl-tRNA hydrolase activity
B6R96_RS21300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B6R96_RS21305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6R96_RS21310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6R96_RS21320	COG4585	Histidine kinase
B6R96_RS21360	COG0596	Alpha beta hydrolase
B6R96_RS21380	COG2814	Major facilitator Superfamily
B6R96_RS21390	COG1136	(ABC) transporter
B6R96_RS21395	COG0577	efflux transmembrane transporter activity
B6R96_RS21415	COG0515	serine threonine protein kinase
B6R96_RS21415	COG2815	serine threonine protein kinase
B6R96_RS21440	COG2124	cytochrome p450
B6R96_RS21455	COG0148	phosphopyruvate hydratase activity
B6R96_RS21475	COG1252	NADH dehydrogenase
B6R96_RS21480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6R96_RS21485	COG0577	efflux transmembrane transporter activity
B6R96_RS21490	COG0577	efflux transmembrane transporter activity
B6R96_RS21490	COG1136	(ABC) transporter
B6R96_RS21520	COG0183	Belongs to the thiolase family
B6R96_RS21525	COG2755	lipolytic protein G-D-S-L family
B6R96_RS21550	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B6R96_RS21555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6R96_RS21565	COG1228	amidohydrolase
B6R96_RS21590	COG3104	oligopeptide transport
B6R96_RS21595	COG0745	RESPONSE REGULATOR receiver
B6R96_RS21600	COG2205	protein histidine kinase activity
B6R96_RS21630	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B6R96_RS21640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6R96_RS21645	COG1316	TRANSCRIPTIONal
B6R96_RS21650	COG1607	acyl-coa hydrolase
B6R96_RS21670	COG1316	TRANSCRIPTIONal
B6R96_RS21675	COG1316	TRANSCRIPTIONal
B6R96_RS21695	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B6R96_RS21695	COG0778	Nitroreductase
B6R96_RS21700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B6R96_RS21735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6R96_RS21740	COG2835	tetraacyldisaccharide 4'-kinase activity
B6R96_RS21750	COG1482	cell wall glycoprotein biosynthetic process
B6R96_RS21760	COG0681	Belongs to the peptidase S26 family
B6R96_RS21765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6R96_RS21765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6R96_RS21765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6R96_RS21770	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B6R96_RS21825	COG0714	Associated with various cellular activities
B6R96_RS21845	COG0745	RESPONSE REGULATOR receiver
B6R96_RS21850	COG5002	protein histidine kinase activity
B6R96_RS21850	COG5000	phosphorelay sensor kinase activity
B6R96_RS21855	COG0823	Involved in the tonB-independent uptake of proteins
B6R96_RS21865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B6R96_RS21870	COG2197	response regulator
B6R96_RS21885	COG0653	protein targeting
B6R96_RS21900	COG0546	phosphoglycolate phosphatase activity
B6R96_RS21910	COG1134	teichoic acid transport
B6R96_RS21910	COG1388	LysM domain
B6R96_RS21925	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6R96_RS21925	COG0463	Glycosyl transferase, family 2
B6R96_RS21930	COG0395	ABC-type sugar transport system, permease component
B6R96_RS21935	COG1175	transmembrane transport
B6R96_RS21940	COG1653	transport
B6R96_RS21950	COG0515	serine threonine protein kinase
B6R96_RS21955	COG0515	serine threonine protein kinase
B6R96_RS21965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B6R96_RS21975	COG2884	Cell division ATP-binding protein ftsE
B6R96_RS21980	COG2177	Part of the ABC transporter FtsEX involved in
B6R96_RS21985	COG0793	Belongs to the peptidase S41A family
B6R96_RS21990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B6R96_RS22015	COG0583	DNA-binding transcription factor activity
B6R96_RS22040	COG3973	AAA domain
B6R96_RS22050	COG0776	regulation of translation
B6R96_RS22055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6R96_RS22060	COG1678	Uncharacterized ACR, COG1678
B6R96_RS22070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B6R96_RS22100	COG1404	Belongs to the peptidase S8 family
B6R96_RS22115	COG3654	unkown
B6R96_RS22150	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B6R96_RS22160	COG0277	FAD linked oxidase domain protein
B6R96_RS22195	COG1335	isochorismatase
B6R96_RS22205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B6R96_RS22215	COG1113	amino acid transport
B6R96_RS22235	COG3189	MarR family transcriptional regulator
B6R96_RS22245	COG1234	tRNA 3'-trailer cleavage
B6R96_RS22250	COG1263	PTS System
B6R96_RS22255	COG1263	PTS System
B6R96_RS22260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6R96_RS22265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B6R96_RS22275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6R96_RS22310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6R96_RS22325	COG4555	ABC transporter
B6R96_RS22335	COG2733	membrane
B6R96_RS22370	COG3764	Sortase (surface protein transpeptidase)
B6R96_RS22380	COG0706	membrane insertase activity
B6R96_RS22385	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6R96_RS22390	COG0673	inositol 2-dehydrogenase activity
B6R96_RS22395	COG1940	carbohydrate kinase activity
B6R96_RS22395	COG1846	Transcriptional regulator
B6R96_RS22405	COG2188	Transcriptional regulator
B6R96_RS22410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6R96_RS22475	COG3397	chitin binding
B6R96_RS22480	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS22495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS22580	COG4221	oxidoreductase activity
B6R96_RS22585	COG1309	transcriptional regulator
B6R96_RS22610	COG0406	alpha-ribazole phosphatase activity
B6R96_RS22625	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B6R96_RS22630	COG0500	methyltransferase
B6R96_RS22640	COG0745	RESPONSE REGULATOR receiver
B6R96_RS22665	COG0702	epimerase
B6R96_RS22675	COG0395	ABC-type sugar transport system, permease component
B6R96_RS22700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B6R96_RS22705	COG4977	sequence-specific DNA binding
B6R96_RS22715	COG0589	response to stress
B6R96_RS22730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6R96_RS22755	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B6R96_RS22760	COG0076	glutamate decarboxylase activity
B6R96_RS22765	COG2375	cellular response to nickel ion
B6R96_RS22775	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS22790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6R96_RS22795	COG1309	transcriptional regulator
B6R96_RS22805	COG1946	Acyl-CoA thioesterase
B6R96_RS22825	COG0028	Belongs to the TPP enzyme family
B6R96_RS22870	COG1472	Belongs to the glycosyl hydrolase 3 family
B6R96_RS22885	COG0456	acetyltransferase
B6R96_RS22885	COG1846	Transcriptional regulator
B6R96_RS22895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6R96_RS22920	COG0673	inositol 2-dehydrogenase activity
B6R96_RS22925	COG1082	Xylose isomerase domain protein TIM barrel
B6R96_RS22935	COG3718	enzyme involved in inositol metabolism
B6R96_RS22940	COG3962	Belongs to the TPP enzyme family
B6R96_RS22995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B6R96_RS23025	COG0629	single-stranded DNA binding
B6R96_RS23055	COG2346	COG2346, Truncated hemoglobins
B6R96_RS23060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6R96_RS23085	COG1011	Hydrolase
B6R96_RS23115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6R96_RS23130	COG1486	melibiose metabolic process
B6R96_RS23135	COG0395	ABC-type sugar transport system, permease component
B6R96_RS23140	COG1175	transmembrane transport
B6R96_RS23155	COG0668	transmembrane transport
B6R96_RS23165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B6R96_RS23165	COG3291	Pkd domain containing protein
B6R96_RS23180	COG1846	Transcriptional regulator
B6R96_RS23185	COG0697	spore germination
B6R96_RS23195	COG0583	DNA-binding transcription factor activity
B6R96_RS23210	COG2234	aminopeptidase activity
B6R96_RS23240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B6R96_RS23245	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B6R96_RS23250	COG1113	amino acid transport
B6R96_RS23260	COG1113	amino acid transport
B6R96_RS23270	COG1113	amino acid transport
B6R96_RS23285	COG4552	Acetyltransferase involved in intracellular survival and related
B6R96_RS23330	COG0544	peptidyl-prolyl cis-trans isomerase activity
B6R96_RS23335	COG0740	serine-type endopeptidase activity
B6R96_RS23340	COG0740	serine-type endopeptidase activity
B6R96_RS23345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B6R96_RS23355	COG0525	valine-tRNA ligase activity
B6R96_RS23360	COG4585	Histidine kinase
B6R96_RS23365	COG1077	Cell shape determining protein MreB Mrl
B6R96_RS23370	COG0285	dihydrofolate synthase activity
B6R96_RS23380	COG0105	UTP biosynthetic process
B6R96_RS23385	COG1077	Cell shape determining protein MreB Mrl
B6R96_RS23400	COG0768	penicillin binding
B6R96_RS23405	COG0772	Belongs to the SEDS family
B6R96_RS23430	COG1530	ribonuclease E activity
B6R96_RS23435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B6R96_RS23440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B6R96_RS23445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6R96_RS23450	COG1216	Glycosyl transferase, family 2
B6R96_RS23460	COG0438	transferase activity, transferring glycosyl groups
B6R96_RS23465	COG0463	Glycosyl transferase, family 2
B6R96_RS23465	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6R96_RS23470	COG0463	Glycosyl transferase, family 2
B6R96_RS23480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B6R96_RS23490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B6R96_RS23505	COG0501	Belongs to the peptidase M48B family
B6R96_RS23510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B6R96_RS23520	COG0799	negative regulation of ribosome biogenesis
B6R96_RS23525	COG0588	phosphoglycerate mutase activity
B6R96_RS23545	COG0495	leucyl-tRNA aminoacylation
B6R96_RS23555	COG1307	EDD domain protein, DegV family
B6R96_RS23585	COG0268	Binds directly to 16S ribosomal RNA
B6R96_RS23590	COG0481	GTPase activity
B6R96_RS23615	COG1420	regulation of RNA biosynthetic process
B6R96_RS23620	COG0484	heat shock protein binding
B6R96_RS23625	COG2070	2-Nitropropane dioxygenase
B6R96_RS23635	COG0537	adenosine 5'-monophosphoramidase activity
B6R96_RS23640	COG1234	tRNA 3'-trailer cleavage
B6R96_RS23645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6R96_RS23655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B6R96_RS23665	COG2315	Protein conserved in bacteria
B6R96_RS23675	COG2271	Major facilitator Superfamily
B6R96_RS23690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B6R96_RS23715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6R96_RS23720	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS23730	COG2233	PERMEase
B6R96_RS23735	COG1381	Involved in DNA repair and RecF pathway recombination
B6R96_RS23740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6R96_RS23750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6R96_RS23755	COG1121	(ABC) transporter
B6R96_RS23760	COG0803	Belongs to the bacterial solute-binding protein 9 family
B6R96_RS23760	COG3443	Belongs to the bacterial solute-binding protein 9 family
B6R96_RS23765	COG0423	glycine-tRNA ligase activity
B6R96_RS23775	COG1309	transcriptional regulator
B6R96_RS23780	COG0667	Aldo Keto reductase
B6R96_RS23795	COG0477	Major facilitator Superfamily
B6R96_RS23805	COG0574	Belongs to the PEP-utilizing enzyme family
B6R96_RS23805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6R96_RS23825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6R96_RS23825	COG2146	nitrite reductase [NAD(P)H] activity
B6R96_RS23830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6R96_RS23830	COG2146	nitrite reductase [NAD(P)H] activity
B6R96_RS23835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6R96_RS23865	COG2205	protein histidine kinase activity
B6R96_RS23880	COG0358	DNA primase activity
B6R96_RS23890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B6R96_RS23900	COG2949	membrane
B6R96_RS23915	COG0243	molybdopterin cofactor binding
B6R96_RS23940	COG1070	Carbohydrate kinase
B6R96_RS23970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6R96_RS23975	COG0477	Major facilitator Superfamily
B6R96_RS23980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B6R96_RS23980	COG0825	malonyl-CoA metabolic process
B6R96_RS23995	COG1522	sequence-specific DNA binding
B6R96_RS24005	COG1077	Cell shape determining protein MreB Mrl
B6R96_RS24010	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B6R96_RS24030	COG2130	NADP-dependent
B6R96_RS24035	COG1764	response to oxidative stress
B6R96_RS24050	COG1733	regulation of RNA biosynthetic process
B6R96_RS24060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6R96_RS24065	COG1309	transcriptional regulator
B6R96_RS24085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6R96_RS24090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6R96_RS24095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6R96_RS24120	COG0789	Transcriptional regulator
B6R96_RS24125	COG0667	Aldo Keto reductase
B6R96_RS24140	COG1309	transcriptional regulator
B6R96_RS24150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6R96_RS24155	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B6R96_RS24200	COG1358	cellular component organization or biogenesis
B6R96_RS24295	COG2318	DinB family
B6R96_RS24300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6R96_RS24350	COG2124	cytochrome p450
B6R96_RS24355	COG0183	Belongs to the thiolase family
B6R96_RS24370	COG3845	ABC transporter
B6R96_RS24385	COG1657	PFAM Prenyltransferase squalene oxidase
B6R96_RS24390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6R96_RS24410	COG1309	transcriptional regulator
B6R96_RS24415	COG0438	transferase activity, transferring glycosyl groups
B6R96_RS24450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS24480	COG0515	serine threonine protein kinase
B6R96_RS24480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6R96_RS24490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B6R96_RS24495	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS24500	COG0183	Belongs to the thiolase family
B6R96_RS24515	COG1595	DNA-templated transcription, initiation
B6R96_RS24525	COG2030	dehydratase
B6R96_RS24535	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS24545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B6R96_RS24585	COG3022	response to hydroperoxide
B6R96_RS24600	COG1834	amidinotransferase
B6R96_RS24610	COG2814	Major facilitator Superfamily
B6R96_RS24620	COG0384	phenazine biosynthesis protein PhzF
B6R96_RS24625	COG0672	)-iron permease
B6R96_RS24630	COG2837	iron assimilation
B6R96_RS24640	COG1120	ATPase activity
B6R96_RS24645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6R96_RS24650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B6R96_RS24700	COG1994	Peptidase M50
B6R96_RS24720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B6R96_RS24730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6R96_RS24730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6R96_RS24740	COG2132	Multicopper oxidase
B6R96_RS24755	COG2267	carboxylic ester hydrolase activity
B6R96_RS24780	COG0174	glutamine synthetase
B6R96_RS24825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B6R96_RS24830	COG2340	Cysteine-rich secretory protein family
B6R96_RS24845	COG3511	phospholipase C
B6R96_RS24865	COG1609	Transcriptional regulator
B6R96_RS24870	COG0366	Alpha amylase catalytic
B6R96_RS24880	COG1175	transmembrane transport
B6R96_RS24890	COG0366	Alpha amylase catalytic
B6R96_RS24955	COG2365	Tyrosine phosphatase family
B6R96_RS24975	COG0745	RESPONSE REGULATOR receiver
B6R96_RS24990	COG0673	inositol 2-dehydrogenase activity
B6R96_RS25000	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6R96_RS25005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6R96_RS25010	COG1846	Transcriptional regulator
B6R96_RS25060	COG0321	lipoyl(octanoyl) transferase activity
B6R96_RS25065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B6R96_RS25110	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B6R96_RS25120	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6R96_RS25125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6R96_RS25130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B6R96_RS25160	COG4585	Histidine kinase
B6R96_RS25170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6R96_RS25170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6R96_RS25175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B6R96_RS25190	COG2226	methyltransferase
B6R96_RS25215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B6R96_RS25220	COG2197	response regulator
B6R96_RS25225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6R96_RS25230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B6R96_RS25250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6R96_RS25260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B6R96_RS25265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6R96_RS25275	COG1376	ErfK ybiS ycfS ynhG family protein
B6R96_RS25285	COG1845	cytochrome c oxidase, subunit III
B6R96_RS25290	COG2010	Cytochrome c
B6R96_RS25295	COG0723	plastoquinol--plastocyanin reductase activity
B6R96_RS25300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6R96_RS25305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6R96_RS25310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6R96_RS25335	COG0791	NLP P60 protein
B6R96_RS25350	COG0438	transferase activity, transferring glycosyl groups
B6R96_RS25375	COG0003	Pfam Anion-transporting ATPase
B6R96_RS25385	COG1940	carbohydrate kinase activity
B6R96_RS25410	COG4585	Histidine kinase
B6R96_RS25415	COG2197	response regulator
B6R96_RS25420	COG0205	6-phosphofructokinase activity
B6R96_RS25425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6R96_RS25435	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B6R96_RS25445	COG2193	ferroxidase activity
B6R96_RS25450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B6R96_RS25460	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B6R96_RS25465	COG0515	serine threonine protein kinase
B6R96_RS25465	COG2815	serine threonine protein kinase
B6R96_RS25470	COG2022	thiamine diphosphate biosynthetic process
B6R96_RS25480	COG2022	thiamine diphosphate biosynthetic process
B6R96_RS25480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6R96_RS25495	COG0352	thiamine-phosphate diphosphorylase activity
B6R96_RS25510	COG1233	COG1233 Phytoene dehydrogenase and related
B6R96_RS25525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6R96_RS25535	COG1131	(ABC) transporter
B6R96_RS25545	COG1309	transcriptional regulator
B6R96_RS25560	COG0714	Associated with various cellular activities
B6R96_RS25570	COG0275	rRNA processing
B6R96_RS25580	COG0768	penicillin binding
B6R96_RS25585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6R96_RS25595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6R96_RS25600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B6R96_RS25610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B6R96_RS25615	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B6R96_RS25635	COG1799	cell septum assembly
B6R96_RS25650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B6R96_RS25665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B6R96_RS25805	COG0587	DNA-directed DNA polymerase activity
B6R96_RS25810	COG1432	Conserved Protein
B6R96_RS25830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B6R96_RS25845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6R96_RS25850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6R96_RS25855	COG0131	Imidazoleglycerol-phosphate dehydratase
B6R96_RS25860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6R96_RS25865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B6R96_RS25870	COG0251	oxidation-reduction process
B6R96_RS25875	COG0107	imidazoleglycerol-phosphate synthase activity
B6R96_RS25885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B6R96_RS25910	COG0134	indole-3-glycerol-phosphate synthase activity
B6R96_RS25920	COG0133	tryptophan synthase activity
B6R96_RS25925	COG0159	tryptophan synthase activity
B6R96_RS25935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B6R96_RS25940	COG2301	Belongs to the HpcH HpaI aldolase family
B6R96_RS25945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B6R96_RS25950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6R96_RS25980	COG0069	glutamate synthase activity
B6R96_RS25980	COG0070	glutamate synthase
B6R96_RS25980	COG0067	glutamate synthase
B6R96_RS26005	COG1725	Transcriptional regulator
B6R96_RS26010	COG1131	(ABC) transporter
B6R96_RS26055	COG0657	acetylesterase activity
B6R96_RS26085	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS26095	COG1309	transcriptional regulator
B6R96_RS26100	COG0183	Belongs to the thiolase family
B6R96_RS26110	COG1278	Cold shock
B6R96_RS26120	COG2365	Tyrosine phosphatase family
B6R96_RS26140	COG1024	Enoyl-CoA hydratase
B6R96_RS26150	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS26175	COG2197	response regulator
B6R96_RS26195	COG1605	Chorismate mutase
B6R96_RS26195	COG0287	Prephenate dehydrogenase
B6R96_RS26215	COG0737	Belongs to the 5'-nucleotidase family
B6R96_RS26320	COG1643	Atp-dependent helicase
B6R96_RS26325	COG1073	alpha beta
B6R96_RS26325	COG2226	methyltransferase
B6R96_RS26330	COG0539	negative regulation of cytoplasmic translation
B6R96_RS26340	COG0237	dephospho-CoA kinase activity
B6R96_RS26365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B6R96_RS26370	COG4279	zinc finger
B6R96_RS26385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6R96_RS26415	COG2313	pseudouridylate synthase activity
B6R96_RS26420	COG2226	methyltransferase
B6R96_RS26430	COG0477	Major facilitator Superfamily
B6R96_RS26435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6R96_RS26440	COG0584	glycerophosphoryl diester phosphodiesterase
B6R96_RS26445	COG0556	nucleotide-excision repair
B6R96_RS26465	COG0477	Major facilitator Superfamily
B6R96_RS26470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6R96_RS26480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6R96_RS26510	COG0322	excinuclease ABC activity
B6R96_RS26515	COG1660	Displays ATPase and GTPase activities
B6R96_RS26525	COG1481	regulation of sporulation
B6R96_RS26535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B6R96_RS26540	COG0126	phosphoglycerate kinase activity
B6R96_RS26545	COG0149	triose-phosphate isomerase activity
B6R96_RS26550	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6R96_RS26560	COG0166	Belongs to the GPI family
B6R96_RS26565	COG0363	glucosamine-6-phosphate deaminase activity
B6R96_RS26580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B6R96_RS26590	COG0109	protoheme IX farnesyltransferase activity
B6R96_RS26605	COG1612	heme a metabolic process
B6R96_RS26620	COG1131	(ABC) transporter
B6R96_RS26635	COG0719	Fe-S assembly protein
B6R96_RS26645	COG0396	ATPase activity
B6R96_RS26650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6R96_RS26655	COG0822	iron-sulfur transferase activity
B6R96_RS26660	COG2151	metal-sulfur cluster biosynthetic enzyme
B6R96_RS26670	COG2076	Multidrug Resistance protein
B6R96_RS26675	COG3226	Transcriptional regulator
B6R96_RS26690	COG2171	N-acyltransferase activity
B6R96_RS26740	COG4585	Histidine kinase
B6R96_RS26745	COG2197	response regulator
B6R96_RS26765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6R96_RS26795	COG1797	cobyrinic acid a,c-diamide synthase activity
B6R96_RS26810	COG1492	cobalamin metabolic process
B6R96_RS26815	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B6R96_RS26825	COG0306	phosphate transporter
B6R96_RS26850	COG0488	(ABC) transporter
B6R96_RS26860	COG1024	Enoyl-CoA hydratase
B6R96_RS26865	COG1302	Protein conserved in bacteria
B6R96_RS26890	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS26950	COG1063	alcohol dehydrogenase
B6R96_RS26965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B6R96_RS26970	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6R96_RS26990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6R96_RS27005	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS27010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6R96_RS27020	COG2186	Transcriptional regulator
B6R96_RS27040	COG3830	Belongs to the UPF0237 family
B6R96_RS27040	COG0560	Phosphoserine phosphatase
B6R96_RS27050	COG1131	(ABC) transporter
B6R96_RS27050	COG0842	Transport permease protein
B6R96_RS27050	COG1716	ATPase activity
B6R96_RS27060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B6R96_RS27065	COG4221	oxidoreductase activity
B6R96_RS27070	COG4585	Histidine kinase
B6R96_RS27075	COG2197	response regulator
B6R96_RS27090	COG1119	ATPase activity
B6R96_RS27115	COG1881	PFAM PEBP family protein
B6R96_RS27125	COG2094	Belongs to the DNA glycosylase MPG family
B6R96_RS27165	COG0647	UMP catabolic process
B6R96_RS27170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6R96_RS27175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6R96_RS27180	COG1120	ATPase activity
B6R96_RS27200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6R96_RS27205	COG0497	DNA recombination
B6R96_RS27210	COG0297	glycogen (starch) synthase activity
B6R96_RS27220	COG0277	FAD linked oxidase domain protein
B6R96_RS27225	COG3387	PFAM Glycoside hydrolase 15-related
B6R96_RS27230	COG0504	CTP synthase activity
B6R96_RS27235	COG0494	nUDIX hydrolase
B6R96_RS27245	COG0686	Belongs to the AlaDH PNT family
B6R96_RS27260	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B6R96_RS27265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6R96_RS27270	COG1187	pseudouridine synthase activity
B6R96_RS27295	COG3541	Predicted nucleotidyltransferase
B6R96_RS27325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B6R96_RS27335	COG1160	GTP binding
B6R96_RS27365	COG0671	phosphoesterase, PA-phosphatase related
B6R96_RS27375	COG0477	Major facilitator Superfamily
B6R96_RS27385	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS27390	COG1799	cell septum assembly
B6R96_RS27435	COG0641	radical SAM
B6R96_RS27465	COG0587	DNA-directed DNA polymerase activity
B6R96_RS27470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6R96_RS27505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B6R96_RS27515	COG1660	Displays ATPase and GTPase activities
B6R96_RS27540	COG0494	nUDIX hydrolase
B6R96_RS27615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6R96_RS27640	COG2755	lipolytic protein G-D-S-L family
B6R96_RS27680	COG2188	Transcriptional regulator
B6R96_RS27685	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B6R96_RS27705	COG1309	transcriptional regulator
B6R96_RS27710	COG0243	molybdopterin cofactor binding
B6R96_RS27715	COG2851	Citrate transporter
B6R96_RS27740	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS27760	COG0789	Transcriptional regulator
B6R96_RS27780	COG3876	Protein conserved in bacteria
B6R96_RS27785	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS27790	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS27805	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS27830	COG2149	membrane
B6R96_RS27835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B6R96_RS27860	COG1113	amino acid transport
B6R96_RS27880	COG1595	DNA-templated transcription, initiation
B6R96_RS27890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6R96_RS27920	COG0667	Aldo Keto reductase
B6R96_RS27925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS27935	COG0598	Magnesium transport protein CorA
B6R96_RS27955	COG0215	cysteine-tRNA ligase activity
B6R96_RS27965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B6R96_RS27970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6R96_RS27975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6R96_RS27980	COG1414	Transcriptional regulator
B6R96_RS28005	COG2197	response regulator
B6R96_RS28015	COG0517	IMP dehydrogenase activity
B6R96_RS28015	COG1994	Peptidase M50
B6R96_RS28035	COG1222	aaa ATPase
B6R96_RS28040	COG4122	O-methyltransferase activity
B6R96_RS28055	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6R96_RS28060	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6R96_RS28065	COG1609	Transcriptional regulator
B6R96_RS28075	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6R96_RS28110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6R96_RS28115	COG0805	protein transport
B6R96_RS28130	COG1309	transcriptional regulator
B6R96_RS28135	COG0564	pseudouridine synthase activity
B6R96_RS28155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6R96_RS28165	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B6R96_RS28195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B6R96_RS28200	COG1113	amino acid transport
B6R96_RS28210	COG0174	glutamine synthetase
B6R96_RS28215	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS28220	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS28260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B6R96_RS28265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B6R96_RS28270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B6R96_RS28275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6R96_RS28280	COG5002	protein histidine kinase activity
B6R96_RS28285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B6R96_RS28290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6R96_RS28290	COG0072	phenylalanine-tRNA ligase activity
B6R96_RS28310	COG1649	PFAM Uncharacterised BCR, COG1649
B6R96_RS28320	COG0697	spore germination
B6R96_RS28335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B6R96_RS28340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B6R96_RS28345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B6R96_RS28350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6R96_RS28355	COG1438	arginine binding
B6R96_RS28370	COG0137	argininosuccinate synthase activity
B6R96_RS28375	COG0165	Argininosuccinate lyase
B6R96_RS28390	COG0477	Major facilitator Superfamily
B6R96_RS28400	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS28400	COG0204	Acyl-transferase
B6R96_RS28405	COG0584	glycerophosphoryl diester phosphodiesterase
B6R96_RS28430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6R96_RS28435	COG2011	ABC-type metal ion transport system permease component
B6R96_RS28440	COG1464	Belongs to the NlpA lipoprotein family
B6R96_RS28455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B6R96_RS28460	COG1648	precorrin-2 dehydrogenase activity
B6R96_RS28460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6R96_RS28505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6R96_RS28515	COG0456	acetyltransferase
B6R96_RS28515	COG0454	-acetyltransferase
B6R96_RS28560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6R96_RS28585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6R96_RS28610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6R96_RS28615	COG1560	Kdo2-lipid A biosynthetic process
B6R96_RS28620	COG0438	transferase activity, transferring glycosyl groups
B6R96_RS28630	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B6R96_RS28635	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B6R96_RS28640	COG0217	transcriptional regulatory protein
B6R96_RS28645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B6R96_RS28650	COG0632	four-way junction helicase activity
B6R96_RS28655	COG2255	four-way junction helicase activity
B6R96_RS28665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6R96_RS28670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6R96_RS28675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6R96_RS28680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6R96_RS28685	COG1196	nuclear chromosome segregation
B6R96_RS28690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B6R96_RS28700	COG0124	histidyl-tRNA synthetase
B6R96_RS28725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6R96_RS28745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6R96_RS28750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B6R96_RS28760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6R96_RS28770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6R96_RS28775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B6R96_RS28780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6R96_RS28785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B6R96_RS28795	COG0006	proline dipeptidase activity
B6R96_RS28800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6R96_RS28805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6R96_RS28815	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B6R96_RS28820	COG0540	Belongs to the ATCase OTCase family
B6R96_RS28825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6R96_RS28835	COG0505	Belongs to the CarA family
B6R96_RS28840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6R96_RS28845	COG0167	dihydroorotate dehydrogenase activity
B6R96_RS28850	COG0284	orotidine-5'-phosphate decarboxylase activity
B6R96_RS28860	COG0194	GDP metabolic process
B6R96_RS28875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B6R96_RS28890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6R96_RS28915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B6R96_RS28920	COG2390	Transcriptional regulator
B6R96_RS28950	COG0492	ferredoxin-NADP+ reductase activity
B6R96_RS28965	COG0028	Belongs to the TPP enzyme family
B6R96_RS28985	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B6R96_RS29005	COG1366	Belongs to the anti-sigma-factor antagonist family
B6R96_RS29025	COG2770	Histidine kinase
B6R96_RS29025	COG2208	phosphoserine phosphatase activity
B6R96_RS29030	COG0489	protein tyrosine kinase activity
B6R96_RS29040	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS29070	COG2205	protein histidine kinase activity
B6R96_RS29080	COG3548	integral membrane protein
B6R96_RS29100	COG3275	phosphorelay sensor kinase activity
B6R96_RS29105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B6R96_RS29125	COG2755	lipolytic protein G-D-S-L family
B6R96_RS29130	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS29140	COG0531	amino acid
B6R96_RS29160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6R96_RS29195	COG2233	PERMEase
B6R96_RS29205	COG1846	Transcriptional regulator
B6R96_RS29205	COG1940	carbohydrate kinase activity
B6R96_RS29215	COG1595	DNA-templated transcription, initiation
B6R96_RS29235	COG3201	nicotinamide mononucleotide transporter
B6R96_RS29240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6R96_RS29240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6R96_RS29245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6R96_RS29250	COG0140	phosphoribosyl-ATP diphosphatase activity
B6R96_RS29255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6R96_RS29285	COG0572	uridine kinase
B6R96_RS29300	COG1309	transcriptional regulator
B6R96_RS29305	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS29340	COG0463	Glycosyl transferase, family 2
B6R96_RS29355	COG2270	Major facilitator Superfamily
B6R96_RS29365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6R96_RS29390	COG1984	allophanate hydrolase subunit 2
B6R96_RS29395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B6R96_RS29400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B6R96_RS29430	COG2018	Roadblock/LC7 domain
B6R96_RS29445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6R96_RS29470	COG0640	Transcriptional regulator
B6R96_RS29485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6R96_RS29495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6R96_RS29530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6R96_RS29550	COG1716	ATPase activity
B6R96_RS29570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6R96_RS29580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6R96_RS29580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6R96_RS29615	COG1695	Transcriptional regulator
B6R96_RS29630	COG0697	spore germination
B6R96_RS29690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6R96_RS29705	COG2318	DinB family
B6R96_RS29715	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B6R96_RS29725	COG1968	undecaprenyl-diphosphatase activity
B6R96_RS29740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B6R96_RS29790	COG0110	maltose O-acetyltransferase activity
B6R96_RS29805	COG1832	CoA-binding protein
B6R96_RS29815	COG1739	Uncharacterized protein family UPF0029
B6R96_RS29820	COG0420	3'-5' exonuclease activity
B6R96_RS29825	COG0419	ATPase involved in DNA repair
B6R96_RS29830	COG1522	sequence-specific DNA binding
B6R96_RS29855	COG2267	carboxylic ester hydrolase activity
B6R96_RS29860	COG2188	Transcriptional regulator
B6R96_RS29865	COG1940	carbohydrate kinase activity
B6R96_RS29870	COG2197	response regulator
B6R96_RS29875	COG4585	Histidine kinase
B6R96_RS29900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6R96_RS29920	COG0456	acetyltransferase
B6R96_RS29925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B6R96_RS29930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B6R96_RS29935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B6R96_RS29940	COG0156	8-amino-7-oxononanoate synthase activity
B6R96_RS29965	COG0831	urea catabolic process
B6R96_RS29970	COG0832	Belongs to the urease beta subunit family
B6R96_RS29975	COG0804	urea catabolic process
B6R96_RS29985	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B6R96_RS29990	COG0829	nickel cation binding
B6R96_RS30010	COG0205	6-phosphofructokinase activity
B6R96_RS30015	COG3442	glutamine amidotransferase
B6R96_RS30025	COG0242	peptide deformylase activity
B6R96_RS30035	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS30070	COG0601	transmembrane transport
B6R96_RS30075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6R96_RS30085	COG4608	Belongs to the ABC transporter superfamily
B6R96_RS30105	COG2814	Major facilitator Superfamily
B6R96_RS30110	COG0300	oxidoreductase activity
B6R96_RS30120	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS30130	COG2977	Belongs to the P-Pant transferase superfamily
B6R96_RS30150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS30175	COG0473	3-isopropylmalate dehydrogenase activity
B6R96_RS30180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6R96_RS30190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6R96_RS30195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6R96_RS30220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6R96_RS30220	COG0512	Glutamine amidotransferase of anthranilate synthase
B6R96_RS30225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B6R96_RS30230	COG2814	Major facilitator Superfamily
B6R96_RS30235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6R96_RS30240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6R96_RS30245	COG0156	8-amino-7-oxononanoate synthase activity
B6R96_RS30250	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS30255	COG2124	cytochrome p450
B6R96_RS30285	COG1917	Cupin 2, conserved barrel domain protein
B6R96_RS30285	COG1396	sequence-specific DNA binding
B6R96_RS30290	COG2319	Wd-40 repeat
B6R96_RS30290	COG4249	Peptidase C14 caspase catalytic subunit p20
B6R96_RS30315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6R96_RS30360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6R96_RS30370	COG2824	Alkylphosphonate utilization operon protein PhnA
B6R96_RS30390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6R96_RS30400	COG1309	transcriptional regulator
B6R96_RS30405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6R96_RS30425	COG2814	Major facilitator Superfamily
B6R96_RS30435	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B6R96_RS30475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS30495	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B6R96_RS30500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B6R96_RS30525	COG1595	DNA-templated transcription, initiation
B6R96_RS30535	COG0702	epimerase
B6R96_RS30565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6R96_RS30595	COG1132	(ABC) transporter
B6R96_RS30645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS30645	COG3321	synthase
B6R96_RS30650	COG2409	Drug exporters of the RND superfamily
B6R96_RS30660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6R96_RS30665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6R96_RS30670	COG1120	ATPase activity
B6R96_RS30675	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B6R96_RS30680	COG1132	(ABC) transporter
B6R96_RS30690	COG1132	(ABC) transporter
B6R96_RS30695	COG2382	esterase
B6R96_RS30700	COG1228	amidohydrolase
B6R96_RS30730	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS30740	COG0517	IMP dehydrogenase activity
B6R96_RS30740	COG4175	Glycine betaine
B6R96_RS30745	COG4176	ABC-type proline glycine betaine transport system permease component
B6R96_RS30755	COG0596	Alpha beta hydrolase
B6R96_RS30760	COG0596	Alpha beta hydrolase
B6R96_RS30870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6R96_RS30880	COG1131	(ABC) transporter
B6R96_RS30920	COG2814	Major facilitator Superfamily
B6R96_RS30930	COG2318	DinB family
B6R96_RS30970	COG1012	belongs to the aldehyde dehydrogenase family
B6R96_RS31050	COG2018	Roadblock/LC7 domain
B6R96_RS31060	COG3012	SEC-C Motif Domain Protein
B6R96_RS31065	COG1946	Acyl-CoA thioesterase
B6R96_RS31080	COG1132	(ABC) transporter
B6R96_RS31085	COG1132	(ABC) transporter
B6R96_RS31100	COG1132	(ABC) transporter
B6R96_RS31130	COG2072	flavoprotein involved in K transport
B6R96_RS31145	COG1116	anion transmembrane transporter activity
B6R96_RS31150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6R96_RS31155	COG2124	cytochrome p450
B6R96_RS31170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6R96_RS31185	COG0406	alpha-ribazole phosphatase activity
B6R96_RS31200	COG0475	glutathione-regulated potassium exporter activity
B6R96_RS31240	COG2124	cytochrome p450
B6R96_RS31295	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B6R96_RS31305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6R96_RS31310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS31310	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B6R96_RS31325	COG3629	intracellular signal transduction
B6R96_RS31325	COG3903	Transcriptional regulator
B6R96_RS31350	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B6R96_RS31355	COG2706	6-phosphogluconolactonase activity
B6R96_RS31365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6R96_RS31380	COG1902	pentaerythritol trinitrate reductase activity
B6R96_RS31385	COG0640	Transcriptional regulator
B6R96_RS31410	COG0671	phosphoesterase, PA-phosphatase related
B6R96_RS31495	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B6R96_RS31515	COG0494	nUDIX hydrolase
B6R96_RS31520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6R96_RS31570	COG1940	carbohydrate kinase activity
B6R96_RS31600	COG0464	growth
B6R96_RS31625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6R96_RS31630	COG0488	(ABC) transporter
B6R96_RS31680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6R96_RS31685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS31700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6R96_RS31735	COG0842	Transport permease protein
B6R96_RS31735	COG1716	ATPase activity
B6R96_RS31735	COG1131	(ABC) transporter
B6R96_RS31765	COG4585	Histidine kinase
B6R96_RS31770	COG2197	response regulator
B6R96_RS31790	COG0725	ABC transporter, periplasmic molybdate-binding protein
B6R96_RS31795	COG3585	molybdate ion transport
B6R96_RS31810	COG1461	Dihydroxyacetone kinase
B6R96_RS31835	COG0714	Associated with various cellular activities
B6R96_RS31845	COG2814	Major facilitator Superfamily
B6R96_RS31860	COG0640	Transcriptional regulator
B6R96_RS31900	COG2259	Doxx family
B6R96_RS31905	COG1982	Orn Lys Arg decarboxylase major
B6R96_RS31920	COG3387	PFAM Glycoside hydrolase 15-related
B6R96_RS31930	COG2226	methyltransferase
B6R96_RS31940	COG1063	alcohol dehydrogenase
B6R96_RS31945	COG0156	8-amino-7-oxononanoate synthase activity
B6R96_RS31960	COG1349	DNA-binding transcription factor activity
B6R96_RS31985	COG2318	DinB family
B6R96_RS31990	COG1960	acyl-CoA dehydrogenase activity
B6R96_RS31995	COG0517	IMP dehydrogenase activity
B6R96_RS31995	COG0516	GMP reductase activity
B6R96_RS32015	COG1247	-acetyltransferase
B6R96_RS32020	COG0640	Transcriptional regulator
B6R96_RS32055	COG0346	lactoylglutathione lyase activity
B6R96_RS32075	COG0515	serine threonine protein kinase
B6R96_RS32075	COG2815	serine threonine protein kinase
B6R96_RS32125	COG2070	2-Nitropropane dioxygenase
B6R96_RS32135	COG0387	Pfam Sodium calcium exchanger
B6R96_RS32140	COG2366	antibiotic biosynthetic process
B6R96_RS32145	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS32170	COG1024	Enoyl-CoA hydratase
B6R96_RS32205	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B6R96_RS32205	COG1672	PFAM Archaeal ATPase
B6R96_RS32220	COG1053	succinate dehydrogenase
B6R96_RS32245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6R96_RS32245	COG2010	Cytochrome c
B6R96_RS32260	COG0531	amino acid
B6R96_RS32305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6R96_RS32305	COG0463	Glycosyl transferase, family 2
B6R96_RS32305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6R96_RS32305	COG0463	Glycosyl transferase, family 2
B6R96_RS32315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6R96_RS32355	COG2814	Major facilitator Superfamily
B6R96_RS32440	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS32445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6R96_RS32445	COG0072	phenylalanine-tRNA ligase activity
B6R96_RS32465	COG2910	NAD(P)H-binding
B6R96_RS32525	COG0513	Belongs to the DEAD box helicase family
B6R96_RS32530	COG1846	Transcriptional regulator
B6R96_RS32540	COG1278	Cold shock
B6R96_RS32590	COG4941	Belongs to the sigma-70 factor family
B6R96_RS32600	COG2188	Transcriptional regulator
B6R96_RS32620	COG3842	ATPase activity
B6R96_RS32650	COG2272	Belongs to the type-B carboxylesterase lipase family
B6R96_RS32675	COG1609	Transcriptional regulator
B6R96_RS32690	COG0657	acetylesterase activity
B6R96_RS32720	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6R96_RS32725	COG3473	Maleate cis-trans isomerase
B6R96_RS32785	COG1404	Belongs to the peptidase S8 family
B6R96_RS32850	COG0435	Glutathione S-transferase
B6R96_RS32900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6R96_RS32905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6R96_RS32920	COG0431	NADPH-dependent FMN reductase
B6R96_RS32955	COG0667	Aldo Keto reductase
B6R96_RS32995	COG0667	Aldo Keto reductase
B6R96_RS33015	COG2197	response regulator
B6R96_RS33020	COG4585	Histidine kinase
B6R96_RS33030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6R96_RS33045	COG4989	oxidoreductase activity
B6R96_RS33060	COG2233	PERMEase
B6R96_RS33080	COG1505	serine-type exopeptidase activity
B6R96_RS33115	COG1376	ErfK ybiS ycfS ynhG family protein
B6R96_RS33125	COG0546	phosphoglycolate phosphatase activity
B6R96_RS33135	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS33155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B6R96_RS33160	COG5002	protein histidine kinase activity
B6R96_RS33165	COG0745	RESPONSE REGULATOR receiver
B6R96_RS33210	COG3973	AAA domain
B6R96_RS33220	COG0477	Major facilitator Superfamily
B6R96_RS33260	COG3903	Transcriptional regulator
B6R96_RS33260	COG3629	intracellular signal transduction
B6R96_RS33265	COG2124	cytochrome p450
B6R96_RS33295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6R96_RS33320	COG0702	epimerase
B6R96_RS33390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6R96_RS33405	COG0300	oxidoreductase activity
B6R96_RS33410	COG1309	transcriptional regulator
B6R96_RS33445	COG0456	acetyltransferase
B6R96_RS33450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B6R96_RS33455	COG1917	Cupin 2, conserved barrel domain protein
B6R96_RS33460	COG5285	phytanoyl-CoA dioxygenase
B6R96_RS33485	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B6R96_RS33515	COG2409	Drug exporters of the RND superfamily
B6R96_RS33520	COG1957	nucleoside hydrolase
B6R96_RS33555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6R96_RS33560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6R96_RS33600	COG2124	cytochrome p450
B6R96_RS33605	COG0477	Major facilitator Superfamily
B6R96_RS33610	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B6R96_RS33620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B6R96_RS33635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6R96_RS33640	COG2011	ABC-type metal ion transport system permease component
B6R96_RS33680	COG2272	Belongs to the type-B carboxylesterase lipase family
B6R96_RS33690	COG3864	Putative metallopeptidase domain
B6R96_RS33710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6R96_RS33715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6R96_RS33720	COG0318	PFAM AMP-dependent synthetase and ligase
B6R96_RS33725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6R96_RS33735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6R96_RS33735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6R96_RS33815	COG0483	inositol monophosphate 1-phosphatase activity
B6R96_RS33835	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS33875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6R96_RS33875	COG5549	protein import
B6R96_RS33915	COG1366	Belongs to the anti-sigma-factor antagonist family
B6R96_RS33920	COG1366	Belongs to the anti-sigma-factor antagonist family
B6R96_RS33925	COG2172	sigma factor antagonist activity
B6R96_RS33935	COG2208	phosphoserine phosphatase activity
B6R96_RS33935	COG2770	Histidine kinase
B6R96_RS33970	COG2080	2 iron, 2 sulfur cluster binding
B6R96_RS33975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B6R96_RS33980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6R96_RS34035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6R96_RS34035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6R96_RS34080	COG2135	peptidase activity
B6R96_RS34095	COG1476	TRANSCRIPTIONal
B6R96_RS34200	COG0475	glutathione-regulated potassium exporter activity
B6R96_RS34210	COG4044	May play a role in the intracellular transport of hydrophobic ligands
B6R96_RS34220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6R96_RS34230	COG0642	Histidine kinase
B6R96_RS34235	COG0745	RESPONSE REGULATOR receiver
B6R96_RS34265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6R96_RS34295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6R96_RS34305	COG1278	Cold shock
B6R96_RS34315	COG2340	Cysteine-rich secretory protein family
B6R96_RS34330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6R96_RS34335	COG0785	Cytochrome C biogenesis protein
B6R96_RS34345	COG0745	RESPONSE REGULATOR receiver
B6R96_RS34350	COG2205	protein histidine kinase activity
B6R96_RS34365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6R96_RS34410	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B6R96_RS34425	COG0515	serine threonine protein kinase
B6R96_RS34485	COG1295	ribonuclease BN
B6R96_RS34505	COG0730	response to heat
B6R96_RS34525	COG0154	amidase activity
B6R96_RS34595	COG0477	Major facilitator Superfamily
B6R96_RS34655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6R96_RS34655	COG2755	lipolytic protein G-D-S-L family
B6R96_RS34665	COG3226	Transcriptional regulator
B6R96_RS34670	COG0596	Alpha beta hydrolase
B6R96_RS34680	COG0596	Alpha beta hydrolase
B6R96_RS34685	COG2318	DinB family
B6R96_RS34705	COG2211	Major facilitator Superfamily
B6R96_RS34715	COG1619	proteins homologs of microcin C7 resistance protein MccF
B6R96_RS34745	COG4213	ABC transporter substrate-binding protein
B6R96_RS34755	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6R96_RS34780	COG1366	Belongs to the anti-sigma-factor antagonist family
B6R96_RS34785	COG1191	sigma factor activity
B6R96_RS34845	COG1191	sigma factor activity
B6R96_RS34970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6R96_RS34980	COG1295	ribonuclease BN
B6R96_RS35030	COG1191	sigma factor activity
B6R96_RS35095	COG0300	oxidoreductase activity
B6R96_RS35110	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS35120	COG1028	Short-chain dehydrogenase reductase Sdr
B6R96_RS35130	COG0181	hydroxymethylbilane synthase activity
B6R96_RS35215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6R96_RS35260	COG0477	Major facilitator Superfamily
B6R96_RS35310	COG4977	sequence-specific DNA binding
B6R96_RS35340	COG1132	(ABC) transporter
B6R96_RS35370	COG0402	S-adenosylhomocysteine deaminase activity
B6R96_RS35380	COG2318	DinB family
B6R96_RS35415	COG1335	isochorismatase
B6R96_RS35475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6R96_RS35495	COG2376	Dihydroxyacetone kinase
B6R96_RS35500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6R96_RS35505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6R96_RS35510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B6R96_RS35525	COG3387	PFAM Glycoside hydrolase 15-related
B6R96_RS35535	COG0598	Magnesium transport protein CorA
B6R96_RS35545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B6R96_RS35555	COG3866	Pectate lyase
B6R96_RS35560	COG4677	pectinesterase activity
B6R96_RS35565	COG1595	DNA-templated transcription, initiation
B6R96_RS35575	COG0765	amino acid transport
B6R96_RS35580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS35585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6R96_RS35590	COG1126	abc transporter atp-binding protein
B6R96_RS35610	COG0745	RESPONSE REGULATOR receiver
B6R96_RS35620	COG1126	abc transporter atp-binding protein
B6R96_RS35625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6R96_RS35635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS35640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS35645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS35650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6R96_RS35655	COG0395	ABC-type sugar transport system, permease component
B6R96_RS35660	COG1175	transmembrane transport
B6R96_RS35670	COG0366	Alpha amylase catalytic
B6R96_RS35675	COG1653	transport
B6R96_RS35685	COG1136	(ABC) transporter
B6R96_RS35760	COG2124	cytochrome p450
B6R96_RS35845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6R96_RS35870	COG0596	Alpha beta hydrolase
B6R96_RS35875	COG3467	pyridoxamine 5'-phosphate
B6R96_RS36230	COG0587	DNA-directed DNA polymerase activity
B6R96_RS36250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6R96_RS36330	COG0515	serine threonine protein kinase
B6R96_RS36330	COG2815	serine threonine protein kinase
B6R96_RS36355	COG0791	NLP P60 protein
B6R96_RS36450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B6R96_RS36460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B6R96_RS36500	COG1192	Involved in chromosome partitioning