locus-tag	class	description
C8250_RS00065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C8250_RS00180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C8250_RS00195	COG1335	isochorismatase
C8250_RS00215	COG0477	Major facilitator Superfamily
C8250_RS00255	COG0667	Aldo Keto reductase
C8250_RS00265	COG1309	transcriptional regulator
C8250_RS00285	COG1733	regulation of RNA biosynthetic process
C8250_RS00340	COG0726	polysaccharide deacetylase
C8250_RS00355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C8250_RS00365	COG2205	protein histidine kinase activity
C8250_RS00375	COG2197	response regulator
C8250_RS00380	COG1132	(ABC) transporter
C8250_RS00385	COG1132	(ABC) transporter
C8250_RS00395	COG0515	serine threonine protein kinase
C8250_RS00535	COG1366	Belongs to the anti-sigma-factor antagonist family
C8250_RS00545	COG2132	Multicopper oxidase
C8250_RS00610	COG0745	RESPONSE REGULATOR receiver
C8250_RS00615	COG2205	protein histidine kinase activity
C8250_RS00620	COG1131	(ABC) transporter
C8250_RS00720	COG0656	L-ascorbic acid biosynthetic process
C8250_RS00745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8250_RS00790	COG1942	4-Oxalocrotonate Tautomerase
C8250_RS00815	COG0596	Alpha beta hydrolase
C8250_RS00860	COG3693	PFAM glycoside hydrolase, family 10
C8250_RS00880	COG1595	DNA-templated transcription, initiation
C8250_RS00910	COG0028	Belongs to the TPP enzyme family
C8250_RS00920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8250_RS00985	COG1595	DNA-templated transcription, initiation
C8250_RS01050	COG2226	methyltransferase
C8250_RS01055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C8250_RS01170	COG1228	amidohydrolase
C8250_RS01240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8250_RS01260	COG1063	alcohol dehydrogenase
C8250_RS01330	COG0542	response to heat
C8250_RS01405	COG0789	Transcriptional regulator
C8250_RS01430	COG0667	Aldo Keto reductase
C8250_RS01445	COG1063	alcohol dehydrogenase
C8250_RS01450	COG3387	PFAM Glycoside hydrolase 15-related
C8250_RS01515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C8250_RS01565	COG0076	glutamate decarboxylase activity
C8250_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS01670	COG4977	sequence-specific DNA binding
C8250_RS01700	COG0009	L-threonylcarbamoyladenylate synthase
C8250_RS01705	COG2017	converts alpha-aldose to the beta-anomer
C8250_RS01740	COG3265	gluconokinase activity
C8250_RS01745	COG1132	(ABC) transporter
C8250_RS01750	COG1132	(ABC) transporter
C8250_RS01760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C8250_RS01780	COG0148	phosphopyruvate hydratase activity
C8250_RS01785	COG1309	transcriptional regulator
C8250_RS01805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8250_RS01805	COG0515	serine threonine protein kinase
C8250_RS01845	COG1063	alcohol dehydrogenase
C8250_RS01850	COG0156	8-amino-7-oxononanoate synthase activity
C8250_RS01855	COG0583	DNA-binding transcription factor activity
C8250_RS01865	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C8250_RS01870	COG1181	Belongs to the D-alanine--D-alanine ligase family
C8250_RS01890	COG0745	RESPONSE REGULATOR receiver
C8250_RS01895	COG2205	protein histidine kinase activity
C8250_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS01955	COG0640	Transcriptional regulator
C8250_RS01970	COG0583	DNA-binding transcription factor activity
C8250_RS01985	COG2226	methyltransferase
C8250_RS02020	COG0667	Aldo Keto reductase
C8250_RS02050	COG1940	carbohydrate kinase activity
C8250_RS02085	COG4176	ABC-type proline glycine betaine transport system permease component
C8250_RS02090	COG4175	Glycine betaine
C8250_RS02090	COG0517	IMP dehydrogenase activity
C8250_RS02095	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS02110	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C8250_RS02125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C8250_RS02150	COG2249	NAD(P)H dehydrogenase (quinone) activity
C8250_RS02170	COG0277	FAD linked oxidase domain protein
C8250_RS02190	COG0789	Transcriptional regulator
C8250_RS02200	COG0542	response to heat
C8250_RS02210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS02220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS02225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS02250	COG3251	PFAM MbtH domain protein
C8250_RS02260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C8250_RS02265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C8250_RS02285	COG3483	tryptophan 2,3-dioxygenase activity
C8250_RS02335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C8250_RS02340	COG0151	Belongs to the GarS family
C8250_RS02370	COG0574	Belongs to the PEP-utilizing enzyme family
C8250_RS02370	COG3848	Pyruvate phosphate dikinase
C8250_RS02385	COG3548	integral membrane protein
C8250_RS02420	COG2326	polyphosphate kinase activity
C8250_RS02425	COG1063	alcohol dehydrogenase
C8250_RS02435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8250_RS02435	COG1017	nitric oxide dioxygenase activity
C8250_RS02495	COG3795	YCII-related domain
C8250_RS02500	COG4941	Belongs to the sigma-70 factor family
C8250_RS02545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C8250_RS02550	COG2318	DinB family
C8250_RS02595	COG2409	Drug exporters of the RND superfamily
C8250_RS02610	COG0300	oxidoreductase activity
C8250_RS02620	COG1595	DNA-templated transcription, initiation
C8250_RS02625	COG1376	ErfK ybiS ycfS ynhG family protein
C8250_RS02655	COG1024	Enoyl-CoA hydratase
C8250_RS02720	COG3903	Transcriptional regulator
C8250_RS02720	COG3629	intracellular signal transduction
C8250_RS02770	COG2135	peptidase activity
C8250_RS02900	COG0477	Major facilitator Superfamily
C8250_RS02945	COG0596	Alpha beta hydrolase
C8250_RS02960	COG1063	alcohol dehydrogenase
C8250_RS02990	COG1247	-acetyltransferase
C8250_RS03085	COG0745	RESPONSE REGULATOR receiver
C8250_RS03140	COG0697	spore germination
C8250_RS03190	COG1653	transport
C8250_RS03215	COG0640	Transcriptional regulator
C8250_RS03220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C8250_RS03230	COG0483	inositol monophosphate 1-phosphatase activity
C8250_RS03245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C8250_RS03260	COG2890	protein-(glutamine-N5) methyltransferase activity
C8250_RS03320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C8250_RS03330	COG0477	Major facilitator Superfamily
C8250_RS03360	COG0702	epimerase
C8250_RS03410	COG0137	argininosuccinate synthase activity
C8250_RS03430	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C8250_RS03435	COG2208	phosphoserine phosphatase activity
C8250_RS03435	COG2770	Histidine kinase
C8250_RS03460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C8250_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS03500	COG1309	transcriptional regulator
C8250_RS03525	COG2066	Belongs to the glutaminase family
C8250_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS03635	COG2205	protein histidine kinase activity
C8250_RS03640	COG0745	RESPONSE REGULATOR receiver
C8250_RS03645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C8250_RS03650	COG2226	methyltransferase
C8250_RS03725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8250_RS03745	COG1609	Transcriptional regulator
C8250_RS03755	COG1472	Belongs to the glycosyl hydrolase 3 family
C8250_RS03765	COG4209	transmembrane transport
C8250_RS03770	COG0395	ABC-type sugar transport system, permease component
C8250_RS03815	COG3866	Pectate lyase
C8250_RS03835	COG0395	ABC-type sugar transport system, permease component
C8250_RS03840	COG1175	transmembrane transport
C8250_RS03855	COG1802	Transcriptional regulator
C8250_RS03865	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8250_RS03870	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8250_RS03880	COG1879	ABC-type sugar transport system periplasmic component
C8250_RS03885	COG2160	L-arabinose isomerase activity
C8250_RS03900	COG3866	Pectate lyase
C8250_RS03905	COG1595	DNA-templated transcription, initiation
C8250_RS03925	COG4214	carbohydrate transport
C8250_RS03930	COG1609	Transcriptional regulator
C8250_RS03935	COG0277	FAD linked oxidase domain protein
C8250_RS03940	COG1609	Transcriptional regulator
C8250_RS03965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C8250_RS03970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8250_RS03970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8250_RS04040	COG0583	DNA-binding transcription factor activity
C8250_RS04070	COG3835	regulator
C8250_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS04130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS04145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C8250_RS04155	COG0375	protein maturation
C8250_RS04170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C8250_RS04195	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C8250_RS04200	COG0298	carbon dioxide binding
C8250_RS04220	COG1024	Enoyl-CoA hydratase
C8250_RS04220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C8250_RS04225	COG0667	Aldo Keto reductase
C8250_RS04235	COG1959	2 iron, 2 sulfur cluster binding
C8250_RS04240	COG0596	Alpha beta hydrolase
C8250_RS04245	COG1472	Belongs to the glycosyl hydrolase 3 family
C8250_RS04250	COG2208	phosphoserine phosphatase activity
C8250_RS04270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C8250_RS04280	COG2801	Transposase and inactivated derivatives
C8250_RS04280	COG3415	Transposase
C8250_RS04305	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C8250_RS04380	COG4977	sequence-specific DNA binding
C8250_RS04430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C8250_RS04435	COG2814	Major facilitator Superfamily
C8250_RS04520	COG0183	Belongs to the thiolase family
C8250_RS04530	COG3979	chitinase
C8250_RS04585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C8250_RS04600	COG2197	response regulator
C8250_RS04605	COG4585	Histidine kinase
C8250_RS04620	COG0640	Transcriptional regulator
C8250_RS04640	COG1063	alcohol dehydrogenase
C8250_RS04645	COG0395	ABC-type sugar transport system, permease component
C8250_RS04650	COG1175	transmembrane transport
C8250_RS04670	COG1070	Carbohydrate kinase
C8250_RS04675	COG3347	Dehydrogenase
C8250_RS04675	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS04685	COG1129	ABC transporter
C8250_RS04695	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8250_RS04715	COG1609	Transcriptional regulator
C8250_RS04720	COG1609	Transcriptional regulator
C8250_RS04730	COG1064	alcohol dehydrogenase
C8250_RS04765	COG2318	DinB family
C8250_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS04785	COG0667	Aldo Keto reductase
C8250_RS04815	COG0693	protein deglycase activity
C8250_RS04865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C8250_RS04900	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C8250_RS04900	COG2755	lipolytic protein G-D-S-L family
C8250_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS04935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C8250_RS04945	COG1289	transmembrane transporter activity
C8250_RS04960	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS05015	COG0559	Belongs to the binding-protein-dependent transport system permease family
C8250_RS05050	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C8250_RS05070	COG4977	sequence-specific DNA binding
C8250_RS05090	COG0667	Aldo Keto reductase
C8250_RS05125	COG2205	protein histidine kinase activity
C8250_RS05130	COG0745	RESPONSE REGULATOR receiver
C8250_RS05135	COG1017	nitric oxide dioxygenase activity
C8250_RS05135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8250_RS05175	COG1203	CRISPR-associated helicase, Cas3
C8250_RS05185	COG0583	DNA-binding transcription factor activity
C8250_RS05225	COG2205	protein histidine kinase activity
C8250_RS05230	COG0745	RESPONSE REGULATOR receiver
C8250_RS05250	COG5002	protein histidine kinase activity
C8250_RS05255	COG0745	RESPONSE REGULATOR receiver
C8250_RS05265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C8250_RS05280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C8250_RS05285	COG0477	Major facilitator Superfamily
C8250_RS05295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C8250_RS05305	COG1063	alcohol dehydrogenase
C8250_RS05315	COG2814	Major facilitator Superfamily
C8250_RS05330	COG2368	4-hydroxyphenylacetate
C8250_RS05335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C8250_RS05340	COG0367	asparagine synthase
C8250_RS05350	COG2197	response regulator
C8250_RS05360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS05370	COG0747	negative chemotaxis
C8250_RS05440	COG0583	DNA-binding transcription factor activity
C8250_RS05445	COG5640	endopeptidase activity
C8250_RS05455	COG0702	epimerase
C8250_RS05480	COG0435	Glutathione S-transferase
C8250_RS05515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8250_RS05520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8250_RS05525	COG1120	ATPase activity
C8250_RS05545	COG3537	Alpha-1,2-mannosidase
C8250_RS05610	COG0183	Belongs to the thiolase family
C8250_RS05615	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS05635	COG1476	TRANSCRIPTIONal
C8250_RS05640	COG1064	alcohol dehydrogenase
C8250_RS05645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C8250_RS05650	COG0297	glycogen (starch) synthase activity
C8250_RS05670	COG1597	lipid kinase activity
C8250_RS05675	COG1295	ribonuclease BN
C8250_RS05680	COG0671	phosphoesterase, PA-phosphatase related
C8250_RS05695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8250_RS05725	COG0477	Major facilitator Superfamily
C8250_RS05760	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C8250_RS05765	COG0121	glutamine amidotransferase
C8250_RS05770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C8250_RS05775	COG3572	ergothioneine biosynthetic process
C8250_RS05780	COG0436	Aminotransferase
C8250_RS05800	COG3469	chitinase activity
C8250_RS05825	COG0784	Response regulator, receiver
C8250_RS05825	COG5002	protein histidine kinase activity
C8250_RS05825	COG2205	protein histidine kinase activity
C8250_RS05835	COG1191	sigma factor activity
C8250_RS05840	COG1968	undecaprenyl-diphosphatase activity
C8250_RS05845	COG3979	chitinase
C8250_RS05855	COG3012	SEC-C Motif Domain Protein
C8250_RS05860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C8250_RS05875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8250_RS05880	COG0765	amino acid transport
C8250_RS05885	COG0765	amino acid transport
C8250_RS05890	COG1126	abc transporter atp-binding protein
C8250_RS05895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C8250_RS05905	COG2706	6-phosphogluconolactonase activity
C8250_RS05910	COG3345	alpha-galactosidase
C8250_RS05920	COG0515	serine threonine protein kinase
C8250_RS05945	COG0745	RESPONSE REGULATOR receiver
C8250_RS05975	COG1960	acyl-CoA dehydrogenase activity
C8250_RS05985	COG0242	peptide deformylase activity
C8250_RS06000	COG0205	6-phosphofructokinase activity
C8250_RS06020	COG0204	Acyl-transferase
C8250_RS06075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C8250_RS06080	COG0254	rRNA binding
C8250_RS06095	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C8250_RS06100	COG3285	dna ligase
C8250_RS06100	COG1793	dna ligase
C8250_RS06110	COG1131	(ABC) transporter
C8250_RS06150	COG0504	CTP synthase activity
C8250_RS06165	COG0829	nickel cation binding
C8250_RS06170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C8250_RS06180	COG0804	urea catabolic process
C8250_RS06185	COG0832	Belongs to the urease beta subunit family
C8250_RS06190	COG0831	urea catabolic process
C8250_RS06195	COG4935	Belongs to the peptidase S8 family
C8250_RS06195	COG2234	aminopeptidase activity
C8250_RS06205	COG0740	serine-type endopeptidase activity
C8250_RS06250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C8250_RS06255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C8250_RS06260	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C8250_RS06280	COG0587	DNA-directed DNA polymerase activity
C8250_RS06315	COG5183	chlorophyll binding
C8250_RS06315	COG2133	pyrroloquinoline quinone binding
C8250_RS06335	COG1191	sigma factor activity
C8250_RS06385	COG1136	(ABC) transporter
C8250_RS06385	COG4591	ABC-type transport system involved in lipoprotein release permease component
C8250_RS06390	COG0577	efflux transmembrane transporter activity
C8250_RS06390	COG1136	(ABC) transporter
C8250_RS06415	COG0714	Associated with various cellular activities
C8250_RS06440	COG0784	Response regulator, receiver
C8250_RS06485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C8250_RS06510	COG1302	Protein conserved in bacteria
C8250_RS06530	COG2268	Band 7 protein
C8250_RS06565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C8250_RS06570	COG3663	DNA glycosylase
C8250_RS06575	COG1940	carbohydrate kinase activity
C8250_RS06580	COG2188	Transcriptional regulator
C8250_RS06600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8250_RS06620	COG0326	Molecular chaperone. Has ATPase activity
C8250_RS06635	COG0626	cystathionine gamma-synthase activity
C8250_RS06655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C8250_RS06665	COG1522	sequence-specific DNA binding
C8250_RS06670	COG0419	ATPase involved in DNA repair
C8250_RS06675	COG0420	3'-5' exonuclease activity
C8250_RS06685	COG1739	Uncharacterized protein family UPF0029
C8250_RS06690	COG1832	CoA-binding protein
C8250_RS06715	COG0110	maltose O-acetyltransferase activity
C8250_RS06735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C8250_RS06765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C8250_RS06770	COG0587	DNA-directed DNA polymerase activity
C8250_RS06800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C8250_RS06810	COG1968	undecaprenyl-diphosphatase activity
C8250_RS06820	COG3467	pyridoxamine 5'-phosphate
C8250_RS06825	COG1357	PFAM Pentapeptide repeats (8 copies)
C8250_RS06860	COG1733	regulation of RNA biosynthetic process
C8250_RS06890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C8250_RS06945	COG0019	diaminopimelate decarboxylase activity
C8250_RS06975	COG2814	Major facilitator Superfamily
C8250_RS07000	COG0277	FAD linked oxidase domain protein
C8250_RS07005	COG1597	lipid kinase activity
C8250_RS07030	COG0395	ABC-type sugar transport system, permease component
C8250_RS07035	COG1175	transmembrane transport
C8250_RS07050	COG0531	amino acid
C8250_RS07055	COG2274	protein secretion by the type I secretion system
C8250_RS07090	COG2124	cytochrome p450
C8250_RS07100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C8250_RS07110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C8250_RS07125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C8250_RS07135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8250_RS07155	COG3903	Transcriptional regulator
C8250_RS07155	COG3629	intracellular signal transduction
C8250_RS07195	COG0789	Transcriptional regulator
C8250_RS07205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C8250_RS07210	COG1742	UPF0060 membrane protein
C8250_RS07220	COG0789	Transcriptional regulator
C8250_RS07250	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C8250_RS07270	COG3903	Transcriptional regulator
C8250_RS07270	COG3629	intracellular signal transduction
C8250_RS07290	COG3321	synthase
C8250_RS07290	COG0604	alcohol dehydrogenase
C8250_RS07320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8250_RS07325	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS07330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8250_RS07350	COG0657	acetylesterase activity
C8250_RS07410	COG5433	transposase activity
C8250_RS07435	COG0439	Biotin carboxylase
C8250_RS07440	COG0511	ligase activity, forming carbon-carbon bonds
C8250_RS07445	COG0825	malonyl-CoA metabolic process
C8250_RS07445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C8250_RS07460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8250_RS07465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8250_RS07475	COG0662	Cupin 2, conserved barrel domain protein
C8250_RS07480	COG2329	Antibiotic biosynthesis monooxygenase
C8250_RS07530	COG1793	dna ligase
C8250_RS07540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C8250_RS07550	COG3290	protein histidine kinase activity
C8250_RS07570	COG1472	Belongs to the glycosyl hydrolase 3 family
C8250_RS07605	COG0588	phosphoglycerate mutase activity
C8250_RS07610	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C8250_RS07630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C8250_RS07655	COG4974	Belongs to the 'phage' integrase family
C8250_RS07795	COG2226	methyltransferase
C8250_RS07870	COG2188	Transcriptional regulator
C8250_RS07900	COG0582	viral genome integration into host DNA
C8250_RS07940	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS07945	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS07965	COG4941	Belongs to the sigma-70 factor family
C8250_RS07995	COG0697	spore germination
C8250_RS08030	COG0259	pyridoxamine-phosphate oxidase activity
C8250_RS08050	COG1609	Transcriptional regulator
C8250_RS08055	COG1695	Transcriptional regulator
C8250_RS08060	COG0384	phenazine biosynthesis protein PhzF
C8250_RS08090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C8250_RS08090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C8250_RS08100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C8250_RS08140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C8250_RS08170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C8250_RS08185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8250_RS08190	COG3979	chitinase
C8250_RS08195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C8250_RS08210	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C8250_RS08215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C8250_RS08245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8250_RS08250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C8250_RS08255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C8250_RS08270	COG2018	Roadblock/LC7 domain
C8250_RS08300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C8250_RS08305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C8250_RS08310	COG1984	allophanate hydrolase subunit 2
C8250_RS08370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8250_RS08405	COG1024	Enoyl-CoA hydratase
C8250_RS08415	COG2329	Antibiotic biosynthesis monooxygenase
C8250_RS08440	COG3896	Chloramphenicol phosphotransferase-like protein
C8250_RS08450	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS08455	COG2070	2-Nitropropane dioxygenase
C8250_RS08460	COG0515	serine threonine protein kinase
C8250_RS08470	COG1960	acyl-CoA dehydrogenase activity
C8250_RS08475	COG1309	transcriptional regulator
C8250_RS08485	COG2376	Dihydroxyacetone kinase
C8250_RS08490	COG1461	Dihydroxyacetone kinase
C8250_RS08525	COG2814	Major facilitator Superfamily
C8250_RS08540	COG4974	Belongs to the 'phage' integrase family
C8250_RS08580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8250_RS08585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8250_RS08590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8250_RS08595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8250_RS08600	COG0156	8-amino-7-oxononanoate synthase activity
C8250_RS08605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C8250_RS08610	COG3321	synthase
C8250_RS08610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C8250_RS08620	COG2890	protein-(glutamine-N5) methyltransferase activity
C8250_RS08645	COG1960	acyl-CoA dehydrogenase activity
C8250_RS08655	COG2409	Drug exporters of the RND superfamily
C8250_RS08660	COG3629	intracellular signal transduction
C8250_RS08670	COG0701	Predicted permease
C8250_RS08675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C8250_RS08695	COG0659	secondary active sulfate transmembrane transporter activity
C8250_RS08700	COG0789	Transcriptional regulator
C8250_RS08745	COG4651	solute:proton antiporter activity
C8250_RS08745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C8250_RS08795	COG0038	chloride channel
C8250_RS08830	COG3293	Transposase
C8250_RS08840	COG4974	Belongs to the 'phage' integrase family
C8250_RS08865	COG5433	transposase activity
C8250_RS08960	COG3621	Patatin-like phospholipase
C8250_RS08975	COG4974	Belongs to the 'phage' integrase family
C8250_RS09010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C8250_RS09020	COG1111	helicase
C8250_RS09020	COG1205	dead DEAH box helicase
C8250_RS09025	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C8250_RS09030	COG5433	transposase activity
C8250_RS09040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C8250_RS09050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C8250_RS09055	COG2192	nodulation
C8250_RS09070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C8250_RS09075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C8250_RS09080	COG0438	transferase activity, transferring glycosyl groups
C8250_RS09135	COG0531	amino acid
C8250_RS09155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C8250_RS09165	COG1132	(ABC) transporter
C8250_RS09170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C8250_RS09175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C8250_RS09320	COG0151	Belongs to the GarS family
C8250_RS09385	COG0791	NLP P60 protein
C8250_RS09620	COG1203	CRISPR-associated helicase, Cas3
C8250_RS09630	COG1518	maintenance of DNA repeat elements
C8250_RS09635	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C8250_RS09650	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS09655	COG1051	belongs to the nudix hydrolase family
C8250_RS09670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C8250_RS09675	COG1215	transferase activity, transferring glycosyl groups
C8250_RS09715	COG1349	DNA-binding transcription factor activity
C8250_RS09730	COG2259	Doxx family
C8250_RS09750	COG0395	ABC-type sugar transport system, permease component
C8250_RS09755	COG1175	transmembrane transport
C8250_RS09760	COG1653	transport
C8250_RS09785	COG2267	carboxylic ester hydrolase activity
C8250_RS09810	COG1136	(ABC) transporter
C8250_RS09870	COG2197	response regulator
C8250_RS09875	COG4585	Histidine kinase
C8250_RS09915	COG0395	ABC-type sugar transport system, permease component
C8250_RS09920	COG1175	transmembrane transport
C8250_RS09925	COG1653	transport
C8250_RS09945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C8250_RS10005	COG0584	glycerophosphoryl diester phosphodiesterase
C8250_RS10010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8250_RS10015	COG0765	amino acid transport
C8250_RS10035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8250_RS10040	COG0697	spore germination
C8250_RS10075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C8250_RS10085	COG1309	transcriptional regulator
C8250_RS10095	COG0640	Transcriptional regulator
C8250_RS10100	COG1902	pentaerythritol trinitrate reductase activity
C8250_RS10110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C8250_RS10130	COG2706	6-phosphogluconolactonase activity
C8250_RS10135	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C8250_RS10145	COG1522	sequence-specific DNA binding
C8250_RS10185	COG4249	Peptidase C14 caspase catalytic subunit p20
C8250_RS10185	COG2319	Wd-40 repeat
C8250_RS10215	COG0151	Belongs to the GarS family
C8250_RS10220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C8250_RS10300	COG0432	Pfam Uncharacterised protein family UPF0047
C8250_RS10305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C8250_RS10310	COG1116	anion transmembrane transporter activity
C8250_RS10325	COG1472	Belongs to the glycosyl hydrolase 3 family
C8250_RS10330	COG0492	ferredoxin-NADP+ reductase activity
C8250_RS10335	COG0247	lactate metabolic process
C8250_RS10340	COG1139	Iron-sulfur cluster binding protein
C8250_RS10345	COG1556	Lactate utilization protein
C8250_RS10350	COG1132	(ABC) transporter
C8250_RS10375	COG1132	(ABC) transporter
C8250_RS10380	COG1132	(ABC) transporter
C8250_RS10395	COG1946	Acyl-CoA thioesterase
C8250_RS10405	COG2018	Roadblock/LC7 domain
C8250_RS10420	COG2018	Roadblock/LC7 domain
C8250_RS10435	COG1742	UPF0060 membrane protein
C8250_RS10440	COG2226	methyltransferase
C8250_RS10470	COG0446	pyridine nucleotide-disulphide oxidoreductase
C8250_RS10525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS10570	COG1959	2 iron, 2 sulfur cluster binding
C8250_RS10570	COG1295	ribonuclease BN
C8250_RS10575	COG1686	Belongs to the peptidase S11 family
C8250_RS10580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C8250_RS10635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8250_RS10650	COG2270	Major facilitator Superfamily
C8250_RS10665	COG0463	Glycosyl transferase, family 2
C8250_RS10680	COG1522	sequence-specific DNA binding
C8250_RS10690	COG1960	acyl-CoA dehydrogenase activity
C8250_RS10705	COG3300	MHYT domain
C8250_RS10705	COG5001	Diguanylate cyclase
C8250_RS10715	COG3469	chitinase activity
C8250_RS10730	COG1309	transcriptional regulator
C8250_RS10790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C8250_RS10795	COG0140	phosphoribosyl-ATP diphosphatase activity
C8250_RS10800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C8250_RS10805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C8250_RS10805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C8250_RS10810	COG3201	nicotinamide mononucleotide transporter
C8250_RS10825	COG1940	carbohydrate kinase activity
C8250_RS10825	COG1846	Transcriptional regulator
C8250_RS10870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8250_RS10880	COG0531	amino acid
C8250_RS10900	COG2188	Transcriptional regulator
C8250_RS10910	COG2390	Transcriptional regulator
C8250_RS10915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C8250_RS10920	COG2409	Drug exporters of the RND superfamily
C8250_RS10930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C8250_RS10935	COG0242	peptide deformylase activity
C8250_RS10950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C8250_RS10960	COG1758	RNA polymerase activity
C8250_RS10965	COG0194	GDP metabolic process
C8250_RS10975	COG0284	orotidine-5'-phosphate decarboxylase activity
C8250_RS10980	COG0167	dihydroorotate dehydrogenase activity
C8250_RS10985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C8250_RS10990	COG0505	Belongs to the CarA family
C8250_RS11000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C8250_RS11005	COG0540	Belongs to the ATCase OTCase family
C8250_RS11010	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C8250_RS11025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C8250_RS11030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C8250_RS11035	COG0006	proline dipeptidase activity
C8250_RS11045	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C8250_RS11050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C8250_RS11055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C8250_RS11060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C8250_RS11065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C8250_RS11075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C8250_RS11080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C8250_RS11100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C8250_RS11120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C8250_RS11125	COG1113	amino acid transport
C8250_RS11135	COG0174	glutamine synthetase
C8250_RS11145	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS11160	COG0124	histidyl-tRNA synthetase
C8250_RS11170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C8250_RS11175	COG1196	nuclear chromosome segregation
C8250_RS11180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C8250_RS11185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C8250_RS11190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C8250_RS11195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C8250_RS11205	COG2255	four-way junction helicase activity
C8250_RS11210	COG0632	four-way junction helicase activity
C8250_RS11215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C8250_RS11220	COG0217	transcriptional regulatory protein
C8250_RS11225	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C8250_RS11230	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C8250_RS11240	COG0438	transferase activity, transferring glycosyl groups
C8250_RS11245	COG1560	Kdo2-lipid A biosynthetic process
C8250_RS11250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C8250_RS11270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C8250_RS11285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C8250_RS11345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C8250_RS11405	COG1960	acyl-CoA dehydrogenase activity
C8250_RS11410	COG1960	acyl-CoA dehydrogenase activity
C8250_RS11415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C8250_RS11420	COG1648	precorrin-2 dehydrogenase activity
C8250_RS11420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C8250_RS11425	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C8250_RS11445	COG1464	Belongs to the NlpA lipoprotein family
C8250_RS11450	COG2011	ABC-type metal ion transport system permease component
C8250_RS11495	COG0477	Major facilitator Superfamily
C8250_RS11505	COG0165	Argininosuccinate lyase
C8250_RS11510	COG1438	arginine binding
C8250_RS11515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C8250_RS11520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C8250_RS11525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C8250_RS11530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C8250_RS11650	COG4977	sequence-specific DNA binding
C8250_RS11665	COG0697	spore germination
C8250_RS11670	COG0583	DNA-binding transcription factor activity
C8250_RS11675	COG2813	Specifically methylates the guanine in position
C8250_RS11695	COG1649	PFAM Uncharacterised BCR, COG1649
C8250_RS11705	COG1134	teichoic acid transport
C8250_RS11715	COG1309	transcriptional regulator
C8250_RS11735	COG1051	belongs to the nudix hydrolase family
C8250_RS11745	COG3422	double-strand break repair
C8250_RS11760	COG0072	phenylalanine-tRNA ligase activity
C8250_RS11760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C8250_RS11765	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C8250_RS11770	COG5002	protein histidine kinase activity
C8250_RS11775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C8250_RS11780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C8250_RS11785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C8250_RS11790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C8250_RS11800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C8250_RS11855	COG3448	diguanylate cyclase activity
C8250_RS11855	COG4175	Glycine betaine
C8250_RS11860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C8250_RS11935	COG0805	protein transport
C8250_RS11940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C8250_RS11955	COG2378	regulation of single-species biofilm formation
C8250_RS11960	COG2378	regulation of single-species biofilm formation
C8250_RS11970	COG0545	Peptidyl-prolyl cis-trans isomerase
C8250_RS11975	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C8250_RS11990	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C8250_RS11995	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C8250_RS12010	COG4122	O-methyltransferase activity
C8250_RS12015	COG1222	aaa ATPase
C8250_RS12035	COG1994	Peptidase M50
C8250_RS12035	COG0517	IMP dehydrogenase activity
C8250_RS12045	COG2197	response regulator
C8250_RS12075	COG0747	negative chemotaxis
C8250_RS12080	COG4608	Belongs to the ABC transporter superfamily
C8250_RS12085	COG0444	Belongs to the ABC transporter superfamily
C8250_RS12090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS12095	COG0601	transmembrane transport
C8250_RS12110	COG1410	methionine synthase
C8250_RS12110	COG0646	methionine synthase
C8250_RS12115	COG1414	Transcriptional regulator
C8250_RS12120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C8250_RS12125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C8250_RS12130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C8250_RS12145	COG2186	Transcriptional regulator
C8250_RS12155	COG4214	carbohydrate transport
C8250_RS12160	COG1129	ABC transporter
C8250_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS12175	COG4948	Mandelate Racemase Muconate Lactonizing
C8250_RS12195	COG0215	cysteine-tRNA ligase activity
C8250_RS12210	COG0588	phosphoglycerate mutase activity
C8250_RS12215	COG0598	Magnesium transport protein CorA
C8250_RS12225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS12230	COG0667	Aldo Keto reductase
C8250_RS12260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C8250_RS12275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C8250_RS12275	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C8250_RS12335	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C8250_RS12340	COG2149	membrane
C8250_RS12355	COG0477	Major facilitator Superfamily
C8250_RS12370	COG2186	Transcriptional regulator
C8250_RS12375	COG3265	gluconokinase activity
C8250_RS12390	COG4948	Mandelate Racemase Muconate Lactonizing
C8250_RS12405	COG1960	acyl-CoA dehydrogenase activity
C8250_RS12435	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS12440	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS12480	COG1960	acyl-CoA dehydrogenase activity
C8250_RS12505	COG0243	molybdopterin cofactor binding
C8250_RS12510	COG1309	transcriptional regulator
C8250_RS12515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C8250_RS12520	COG2188	Transcriptional regulator
C8250_RS12535	COG0515	serine threonine protein kinase
C8250_RS12540	COG2755	lipolytic protein G-D-S-L family
C8250_RS12550	COG1725	Transcriptional regulator
C8250_RS12590	COG0330	HflC and HflK could
C8250_RS12610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS12620	COG1799	cell septum assembly
C8250_RS12625	COG0726	polysaccharide deacetylase
C8250_RS12645	COG0671	phosphoesterase, PA-phosphatase related
C8250_RS12660	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS12665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C8250_RS12670	COG0438	transferase activity, transferring glycosyl groups
C8250_RS12720	COG1160	GTP binding
C8250_RS12730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C8250_RS12760	COG3541	Predicted nucleotidyltransferase
C8250_RS12765	COG1187	pseudouridine synthase activity
C8250_RS12770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C8250_RS12775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C8250_RS12790	COG0686	Belongs to the AlaDH PNT family
C8250_RS12800	COG0494	nUDIX hydrolase
C8250_RS12805	COG0504	CTP synthase activity
C8250_RS12810	COG3387	PFAM Glycoside hydrolase 15-related
C8250_RS12815	COG0297	glycogen (starch) synthase activity
C8250_RS12820	COG0497	DNA recombination
C8250_RS12825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C8250_RS12850	COG0647	UMP catabolic process
C8250_RS12880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C8250_RS12885	COG2094	Belongs to the DNA glycosylase MPG family
C8250_RS12895	COG1881	PFAM PEBP family protein
C8250_RS12920	COG1119	ATPase activity
C8250_RS12940	COG2197	response regulator
C8250_RS12945	COG4585	Histidine kinase
C8250_RS12950	COG4221	oxidoreductase activity
C8250_RS12955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C8250_RS12960	COG3953	SLT domain
C8250_RS12960	COG5412	phage tail tape measure protein
C8250_RS12965	COG1131	(ABC) transporter
C8250_RS12965	COG1716	ATPase activity
C8250_RS12965	COG0842	Transport permease protein
C8250_RS12975	COG3830	Belongs to the UPF0237 family
C8250_RS12975	COG0560	Phosphoserine phosphatase
C8250_RS12990	COG2807	transmembrane transport
C8250_RS12995	COG2186	Transcriptional regulator
C8250_RS13000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C8250_RS13025	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C8250_RS13045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C8250_RS13050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8250_RS13095	COG0300	oxidoreductase activity
C8250_RS13125	COG3387	PFAM Glycoside hydrolase 15-related
C8250_RS13130	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS13155	COG1302	Protein conserved in bacteria
C8250_RS13175	COG0488	(ABC) transporter
C8250_RS13195	COG0235	Class ii aldolase
C8250_RS13200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8250_RS13215	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C8250_RS13220	COG1492	cobalamin metabolic process
C8250_RS13240	COG1797	cobyrinic acid a,c-diamide synthase activity
C8250_RS13280	COG0515	serine threonine protein kinase
C8250_RS13295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C8250_RS13305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C8250_RS13310	COG1917	Cupin 2, conserved barrel domain protein
C8250_RS13315	COG5285	phytanoyl-CoA dioxygenase
C8250_RS13330	COG1414	Transcriptional regulator
C8250_RS13335	COG3209	COG3209 Rhs family protein
C8250_RS13335	COG4104	PAAR repeat-containing protein
C8250_RS13360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C8250_RS13365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C8250_RS13370	COG2310	stress, protein
C8250_RS13395	COG2171	N-acyltransferase activity
C8250_RS13410	COG3226	Transcriptional regulator
C8250_RS13415	COG2076	Multidrug Resistance protein
C8250_RS13425	COG2151	metal-sulfur cluster biosynthetic enzyme
C8250_RS13430	COG0822	iron-sulfur transferase activity
C8250_RS13435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C8250_RS13440	COG0396	ATPase activity
C8250_RS13450	COG0719	Fe-S assembly protein
C8250_RS13465	COG1131	(ABC) transporter
C8250_RS13480	COG1612	heme a metabolic process
C8250_RS13495	COG0109	protoheme IX farnesyltransferase activity
C8250_RS13505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C8250_RS13520	COG0363	glucosamine-6-phosphate deaminase activity
C8250_RS13525	COG0166	Belongs to the GPI family
C8250_RS13535	COG4821	SIS domain
C8250_RS13545	COG1737	Transcriptional regulator
C8250_RS13555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C8250_RS13560	COG0149	triose-phosphate isomerase activity
C8250_RS13565	COG0126	phosphoglycerate kinase activity
C8250_RS13570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C8250_RS13575	COG1481	regulation of sporulation
C8250_RS13580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C8250_RS13585	COG1660	Displays ATPase and GTPase activities
C8250_RS13590	COG0322	excinuclease ABC activity
C8250_RS13620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C8250_RS13675	COG0556	nucleotide-excision repair
C8250_RS13690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C8250_RS13705	COG0237	dephospho-CoA kinase activity
C8250_RS13720	COG2226	methyltransferase
C8250_RS13725	COG1643	Atp-dependent helicase
C8250_RS13760	COG2050	protein possibly involved in aromatic compounds catabolism
C8250_RS13820	COG0737	Belongs to the 5'-nucleotidase family
C8250_RS13845	COG1470	cell adhesion involved in biofilm formation
C8250_RS13845	COG0366	Alpha amylase catalytic
C8250_RS13855	COG2197	response regulator
C8250_RS13870	COG0070	glutamate synthase
C8250_RS13870	COG0069	glutamate synthase activity
C8250_RS13870	COG0067	glutamate synthase
C8250_RS13880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C8250_RS13890	COG0159	tryptophan synthase activity
C8250_RS13895	COG0133	tryptophan synthase activity
C8250_RS13900	COG0134	indole-3-glycerol-phosphate synthase activity
C8250_RS13955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C8250_RS13970	COG0583	DNA-binding transcription factor activity
C8250_RS13980	COG1053	succinate dehydrogenase
C8250_RS13985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C8250_RS13990	COG0107	imidazoleglycerol-phosphate synthase activity
C8250_RS13995	COG0251	oxidation-reduction process
C8250_RS14000	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C8250_RS14005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C8250_RS14015	COG0131	Imidazoleglycerol-phosphate dehydratase
C8250_RS14020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C8250_RS14025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C8250_RS14040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C8250_RS14060	COG1432	Conserved Protein
C8250_RS14105	COG2153	protein acetylation
C8250_RS14115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C8250_RS14125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C8250_RS14130	COG3599	regulation of cell shape
C8250_RS14140	COG1799	cell septum assembly
C8250_RS14155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C8250_RS14160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C8250_RS14170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C8250_RS14175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C8250_RS14180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C8250_RS14185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C8250_RS14190	COG0768	penicillin binding
C8250_RS14195	COG0275	rRNA processing
C8250_RS14200	COG2001	Belongs to the MraZ family
C8250_RS14230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C8250_RS14240	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C8250_RS14250	COG1309	transcriptional regulator
C8250_RS14275	COG0352	thiamine-phosphate diphosphorylase activity
C8250_RS14285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C8250_RS14290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8250_RS14290	COG2022	thiamine diphosphate biosynthetic process
C8250_RS14300	COG2022	thiamine diphosphate biosynthetic process
C8250_RS14305	COG0515	serine threonine protein kinase
C8250_RS14305	COG2815	serine threonine protein kinase
C8250_RS14310	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C8250_RS14325	COG2193	ferroxidase activity
C8250_RS14330	COG0243	molybdopterin cofactor binding
C8250_RS14335	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C8250_RS14350	COG0205	6-phosphofructokinase activity
C8250_RS14355	COG2197	response regulator
C8250_RS14385	COG1940	carbohydrate kinase activity
C8250_RS14395	COG0003	Pfam Anion-transporting ATPase
C8250_RS14415	COG0438	transferase activity, transferring glycosyl groups
C8250_RS14425	COG0501	Belongs to the peptidase M48B family
C8250_RS14455	COG0705	Rhomboid family
C8250_RS14465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C8250_RS14470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C8250_RS14475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C8250_RS14480	COG0723	plastoquinol--plastocyanin reductase activity
C8250_RS14485	COG2010	Cytochrome c
C8250_RS14490	COG1845	cytochrome c oxidase, subunit III
C8250_RS14500	COG1376	ErfK ybiS ycfS ynhG family protein
C8250_RS14510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C8250_RS14515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C8250_RS14525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8250_RS14545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C8250_RS14570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C8250_RS14585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C8250_RS14590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C8250_RS14590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C8250_RS14600	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C8250_RS14605	COG3209	COG3209 Rhs family protein
C8250_RS14645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C8250_RS14650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C8250_RS14670	COG0454	-acetyltransferase
C8250_RS14670	COG0456	acetyltransferase
C8250_RS14675	COG1090	epimerase
C8250_RS14690	COG0321	lipoyl(octanoyl) transferase activity
C8250_RS14695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C8250_RS14735	COG2205	protein histidine kinase activity
C8250_RS14745	COG0640	Transcriptional regulator
C8250_RS14750	COG0697	spore germination
C8250_RS14755	COG1619	proteins homologs of microcin C7 resistance protein MccF
C8250_RS14760	COG3321	synthase
C8250_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS14760	COG0604	alcohol dehydrogenase
C8250_RS14765	COG2329	Antibiotic biosynthesis monooxygenase
C8250_RS14815	COG2197	response regulator
C8250_RS14850	COG2182	Extracellular solute-binding protein
C8250_RS14860	COG3833	ABC-type maltose transport systems, permease component
C8250_RS14865	COG0366	Alpha amylase catalytic
C8250_RS14870	COG1609	Transcriptional regulator
C8250_RS14880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C8250_RS14885	COG3511	phospholipase C
C8250_RS14900	COG0277	FAD linked oxidase domain protein
C8250_RS14905	COG0174	glutamine synthetase
C8250_RS14915	COG2132	Multicopper oxidase
C8250_RS14930	COG1175	transmembrane transport
C8250_RS14935	COG0395	ABC-type sugar transport system, permease component
C8250_RS14940	COG0366	Alpha amylase catalytic
C8250_RS14945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8250_RS14945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C8250_RS14955	COG1309	transcriptional regulator
C8250_RS14960	COG0477	Major facilitator Superfamily
C8250_RS14965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C8250_RS15000	COG1994	Peptidase M50
C8250_RS15040	COG2837	iron assimilation
C8250_RS15045	COG0672	)-iron permease
C8250_RS15075	COG1834	amidinotransferase
C8250_RS15085	COG0598	Magnesium transport protein CorA
C8250_RS15095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C8250_RS15100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C8250_RS15105	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C8250_RS15135	COG0489	protein tyrosine kinase activity
C8250_RS15140	COG0297	glycogen (starch) synthase activity
C8250_RS15165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C8250_RS15175	COG2814	Major facilitator Superfamily
C8250_RS15190	COG2154	pterin-4-alpha-carbinolamine dehydratase
C8250_RS15195	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS15205	COG0384	phenazine biosynthesis protein PhzF
C8250_RS15225	COG4974	Belongs to the 'phage' integrase family
C8250_RS15420	COG1181	Belongs to the D-alanine--D-alanine ligase family
C8250_RS15440	COG0305	Participates in initiation and elongation during chromosome replication
C8250_RS15595	COG1051	belongs to the nudix hydrolase family
C8250_RS15655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C8250_RS15665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C8250_RS15705	COG0017	Asparaginyl-tRNA synthetase
C8250_RS15720	COG2826	transposase and inactivated derivatives, IS30 family
C8250_RS15745	COG3209	COG3209 Rhs family protein
C8250_RS15765	COG3022	response to hydroperoxide
C8250_RS15770	COG0800	Aldolase
C8250_RS15785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C8250_RS15795	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS15805	COG2030	dehydratase
C8250_RS15815	COG4585	Histidine kinase
C8250_RS15820	COG2197	response regulator
C8250_RS15835	COG0183	Belongs to the thiolase family
C8250_RS15840	COG1960	acyl-CoA dehydrogenase activity
C8250_RS15850	COG0860	N-Acetylmuramoyl-L-alanine amidase
C8250_RS15860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS15890	COG0438	transferase activity, transferring glycosyl groups
C8250_RS15895	COG1309	transcriptional regulator
C8250_RS15900	COG2197	response regulator
C8250_RS15940	COG3845	ABC transporter
C8250_RS15950	COG0183	Belongs to the thiolase family
C8250_RS15955	COG2124	cytochrome p450
C8250_RS15965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C8250_RS16005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C8250_RS16035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8250_RS16065	COG2175	clavaminate synthase activity
C8250_RS16075	COG2188	Transcriptional regulator
C8250_RS16085	COG3833	ABC-type maltose transport systems, permease component
C8250_RS16095	COG3842	ATPase activity
C8250_RS16100	COG0546	phosphoglycolate phosphatase activity
C8250_RS16125	COG1358	cellular component organization or biogenesis
C8250_RS16195	COG0667	Aldo Keto reductase
C8250_RS16200	COG0789	Transcriptional regulator
C8250_RS16210	COG1741	Belongs to the pirin family
C8250_RS16225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8250_RS16230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8250_RS16235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8250_RS16245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C8250_RS16260	COG0477	Major facilitator Superfamily
C8250_RS16265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C8250_RS16280	COG1309	transcriptional regulator
C8250_RS16285	COG1764	response to oxidative stress
C8250_RS16290	COG2130	NADP-dependent
C8250_RS16315	COG1070	Carbohydrate kinase
C8250_RS16395	COG1024	Enoyl-CoA hydratase
C8250_RS16430	COG0358	DNA primase activity
C8250_RS16450	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C8250_RS16470	COG0243	molybdopterin cofactor binding
C8250_RS16485	COG1335	isochorismatase
C8250_RS16495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C8250_RS16500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C8250_RS16500	COG2146	nitrite reductase [NAD(P)H] activity
C8250_RS16510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8250_RS16515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8250_RS16520	COG1120	ATPase activity
C8250_RS16525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C8250_RS16540	COG2814	Major facilitator Superfamily
C8250_RS16550	COG0019	diaminopimelate decarboxylase activity
C8250_RS16560	COG2267	carboxylic ester hydrolase activity
C8250_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS16570	COG0561	phosphatase activity
C8250_RS16580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C8250_RS16580	COG0574	Belongs to the PEP-utilizing enzyme family
C8250_RS16600	COG0477	Major facilitator Superfamily
C8250_RS16605	COG0667	Aldo Keto reductase
C8250_RS16620	COG2197	response regulator
C8250_RS16635	COG0423	glycine-tRNA ligase activity
C8250_RS16640	COG3443	Belongs to the bacterial solute-binding protein 9 family
C8250_RS16640	COG0803	Belongs to the bacterial solute-binding protein 9 family
C8250_RS16645	COG1121	(ABC) transporter
C8250_RS16650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C8250_RS16660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C8250_RS16665	COG1381	Involved in DNA repair and RecF pathway recombination
C8250_RS16680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C8250_RS16695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C8250_RS16745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C8250_RS16780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C8250_RS16785	COG1309	transcriptional regulator
C8250_RS16820	COG1234	tRNA 3'-trailer cleavage
C8250_RS16825	COG0537	adenosine 5'-monophosphoramidase activity
C8250_RS16830	COG4946	Tricorn protease homolog
C8250_RS16830	COG0793	Belongs to the peptidase S41A family
C8250_RS16850	COG0484	heat shock protein binding
C8250_RS16855	COG1420	regulation of RNA biosynthetic process
C8250_RS16880	COG0481	GTPase activity
C8250_RS16885	COG0268	Binds directly to 16S ribosomal RNA
C8250_RS16925	COG1234	tRNA 3'-trailer cleavage
C8250_RS16930	COG1555	photosystem II stabilization
C8250_RS16935	COG1307	EDD domain protein, DegV family
C8250_RS16945	COG0495	leucyl-tRNA aminoacylation
C8250_RS16960	COG5650	phosphatidylinositol metabolic process
C8250_RS16970	COG0477	Major facilitator Superfamily
C8250_RS16985	COG0697	spore germination
C8250_RS16990	COG1846	Transcriptional regulator
C8250_RS17015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C8250_RS17025	COG0501	Belongs to the peptidase M48B family
C8250_RS17040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C8250_RS17050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C8250_RS17060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C8250_RS17070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C8250_RS17075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C8250_RS17080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C8250_RS17100	COG0531	amino acid
C8250_RS17105	COG1940	carbohydrate kinase activity
C8250_RS17120	COG0772	Belongs to the SEDS family
C8250_RS17125	COG0768	penicillin binding
C8250_RS17140	COG1077	Cell shape determining protein MreB Mrl
C8250_RS17145	COG0105	UTP biosynthetic process
C8250_RS17155	COG0285	dihydrofolate synthase activity
C8250_RS17160	COG0525	valine-tRNA ligase activity
C8250_RS17175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C8250_RS17180	COG0740	serine-type endopeptidase activity
C8250_RS17185	COG0740	serine-type endopeptidase activity
C8250_RS17190	COG0544	peptidyl-prolyl cis-trans isomerase activity
C8250_RS17300	COG0252	asparaginase activity
C8250_RS17315	COG4552	Acetyltransferase involved in intracellular survival and related
C8250_RS17340	COG1113	amino acid transport
C8250_RS17350	COG1113	amino acid transport
C8250_RS17355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C8250_RS17360	COG0346	lactoylglutathione lyase activity
C8250_RS17365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C8250_RS17390	COG1136	(ABC) transporter
C8250_RS17410	COG2226	methyltransferase
C8250_RS17435	COG0697	spore germination
C8250_RS17475	COG0668	transmembrane transport
C8250_RS17490	COG1175	transmembrane transport
C8250_RS17495	COG0395	ABC-type sugar transport system, permease component
C8250_RS17500	COG1486	melibiose metabolic process
C8250_RS17515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8250_RS17525	COG0515	serine threonine protein kinase
C8250_RS17550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C8250_RS17555	COG2346	COG2346, Truncated hemoglobins
C8250_RS17570	COG0577	efflux transmembrane transporter activity
C8250_RS17570	COG1136	(ABC) transporter
C8250_RS17595	COG0629	single-stranded DNA binding
C8250_RS17645	COG2409	Drug exporters of the RND superfamily
C8250_RS17670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C8250_RS17685	COG1082	Xylose isomerase domain protein TIM barrel
C8250_RS17695	COG0673	inositol 2-dehydrogenase activity
C8250_RS17700	COG1609	Transcriptional regulator
C8250_RS17720	COG1472	Belongs to the glycosyl hydrolase 3 family
C8250_RS17735	COG1132	(ABC) transporter
C8250_RS17740	COG0028	Belongs to the TPP enzyme family
C8250_RS17765	COG2197	response regulator
C8250_RS17770	COG4585	Histidine kinase
C8250_RS17775	COG1946	Acyl-CoA thioesterase
C8250_RS17785	COG1309	transcriptional regulator
C8250_RS17790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C8250_RS17805	COG1960	acyl-CoA dehydrogenase activity
C8250_RS17820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C8250_RS17825	COG0589	response to stress
C8250_RS17830	COG4977	sequence-specific DNA binding
C8250_RS17835	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C8250_RS17860	COG0395	ABC-type sugar transport system, permease component
C8250_RS17880	COG0745	RESPONSE REGULATOR receiver
C8250_RS17905	COG0406	alpha-ribazole phosphatase activity
C8250_RS17955	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C8250_RS17960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C8250_RS17965	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C8250_RS17965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C8250_RS17980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C8250_RS17980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C8250_RS18015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS18045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C8250_RS18050	COG2111	Na H antiporter
C8250_RS18050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C8250_RS18055	COG0651	ATP synthesis coupled electron transport
C8250_RS18065	COG0768	penicillin binding
C8250_RS18080	COG1320	monovalent cation:proton antiporter activity
C8250_RS18140	COG2188	Transcriptional regulator
C8250_RS18145	COG1940	carbohydrate kinase activity
C8250_RS18150	COG0673	inositol 2-dehydrogenase activity
C8250_RS18155	COG4702	Belongs to the UPF0303 family
C8250_RS18160	COG0179	Fumarylacetoacetate (FAA) hydrolase
C8250_RS18165	COG0706	membrane insertase activity
C8250_RS18175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8250_RS18185	COG3764	Sortase (surface protein transpeptidase)
C8250_RS18190	COG2733	membrane
C8250_RS18200	COG4555	ABC transporter
C8250_RS18215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C8250_RS18220	COG2076	Multidrug Resistance protein
C8250_RS18255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C8250_RS18265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C8250_RS18270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C8250_RS18275	COG1263	PTS System
C8250_RS18280	COG1263	PTS System
C8250_RS18295	COG1234	tRNA 3'-trailer cleavage
C8250_RS18320	COG1113	amino acid transport
C8250_RS18330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C8250_RS18340	COG1335	isochorismatase
C8250_RS18375	COG0277	FAD linked oxidase domain protein
C8250_RS18380	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C8250_RS18390	COG1174	glycine betaine transport
C8250_RS18400	COG1174	glycine betaine transport
C8250_RS18440	COG3654	unkown
C8250_RS18460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C8250_RS18475	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C8250_RS18485	COG1678	Uncharacterized ACR, COG1678
C8250_RS18490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C8250_RS18495	COG0776	regulation of translation
C8250_RS18505	COG3973	AAA domain
C8250_RS18520	COG2223	nitrite transmembrane transporter activity
C8250_RS18525	COG0583	DNA-binding transcription factor activity
C8250_RS18540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C8250_RS18545	COG3409	Peptidoglycan-binding domain 1 protein
C8250_RS18545	COG0793	Belongs to the peptidase S41A family
C8250_RS18555	COG2884	Cell division ATP-binding protein ftsE
C8250_RS18570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C8250_RS18575	COG0515	serine threonine protein kinase
C8250_RS18580	COG0515	serine threonine protein kinase
C8250_RS18585	COG1674	ftsk spoiiie
C8250_RS18590	COG1653	transport
C8250_RS18595	COG1175	transmembrane transport
C8250_RS18600	COG0395	ABC-type sugar transport system, permease component
C8250_RS18605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C8250_RS18605	COG0463	Glycosyl transferase, family 2
C8250_RS18615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C8250_RS18620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C8250_RS18630	COG2902	Dehydrogenase
C8250_RS18650	COG0653	protein targeting
C8250_RS18655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C8250_RS18660	COG3214	Protein conserved in bacteria
C8250_RS18665	COG2197	response regulator
C8250_RS18670	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C8250_RS18680	COG0823	Involved in the tonB-independent uptake of proteins
C8250_RS18685	COG5002	protein histidine kinase activity
C8250_RS18690	COG0745	RESPONSE REGULATOR receiver
C8250_RS18695	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C8250_RS18715	COG0714	Associated with various cellular activities
C8250_RS18755	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C8250_RS18760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C8250_RS18760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C8250_RS18760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C8250_RS18770	COG1482	cell wall glycoprotein biosynthetic process
C8250_RS18780	COG2835	tetraacyldisaccharide 4'-kinase activity
C8250_RS18820	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C8250_RS18825	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C8250_RS18825	COG0778	Nitroreductase
C8250_RS18835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C8250_RS18860	COG1316	TRANSCRIPTIONal
C8250_RS18875	COG1316	TRANSCRIPTIONal
C8250_RS18895	COG1316	TRANSCRIPTIONal
C8250_RS18910	COG1316	TRANSCRIPTIONal
C8250_RS18915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C8250_RS18950	COG2205	protein histidine kinase activity
C8250_RS18955	COG0745	RESPONSE REGULATOR receiver
C8250_RS18960	COG3104	oligopeptide transport
C8250_RS19000	COG1191	sigma factor activity
C8250_RS19005	COG1228	amidohydrolase
C8250_RS19020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C8250_RS19040	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS19055	COG2755	lipolytic protein G-D-S-L family
C8250_RS19060	COG0183	Belongs to the thiolase family
C8250_RS19090	COG1136	(ABC) transporter
C8250_RS19095	COG1136	(ABC) transporter
C8250_RS19095	COG0577	efflux transmembrane transporter activity
C8250_RS19100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C8250_RS19125	COG0148	phosphopyruvate hydratase activity
C8250_RS19130	COG1652	LysM domain
C8250_RS19140	COG2124	cytochrome p450
C8250_RS19145	COG1515	deoxyribonuclease V activity
C8250_RS19185	COG0463	Glycosyl transferase, family 2
C8250_RS19195	COG0577	efflux transmembrane transporter activity
C8250_RS19200	COG1136	(ABC) transporter
C8250_RS19205	COG0477	Major facilitator Superfamily
C8250_RS19240	COG4585	Histidine kinase
C8250_RS19245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C8250_RS19250	COG1309	transcriptional regulator
C8250_RS19265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C8250_RS19270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C8250_RS19275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C8250_RS19280	COG0193	aminoacyl-tRNA hydrolase activity
C8250_RS19295	COG4106	trans-aconitate 2-methyltransferase activity
C8250_RS19305	COG2197	response regulator
C8250_RS19310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C8250_RS19335	COG0488	(ABC) transporter
C8250_RS19375	COG1366	Belongs to the anti-sigma-factor antagonist family
C8250_RS19390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C8250_RS19395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C8250_RS19405	COG0084	hydrolase, TatD family'
C8250_RS19445	COG5297	Belongs to the glycosyl hydrolase family 6
C8250_RS19450	COG3573	Dehydrogenase
C8250_RS19455	COG1122	ATPase activity
C8250_RS19465	COG0310	cobalt ion transport
C8250_RS19470	COG4946	Tricorn protease homolog
C8250_RS19470	COG0793	Belongs to the peptidase S41A family
C8250_RS19480	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS19485	COG2267	carboxylic ester hydrolase activity
C8250_RS19490	COG2072	flavoprotein involved in K transport
C8250_RS19530	COG0436	Aminotransferase
C8250_RS19540	COG2409	Drug exporters of the RND superfamily
C8250_RS19550	COG0596	Alpha beta hydrolase
C8250_RS19555	COG1609	Transcriptional regulator
C8250_RS19575	COG0521	Mo-molybdopterin cofactor biosynthetic process
C8250_RS19580	COG0315	cyclic pyranopterin monophosphate synthase activity
C8250_RS19590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C8250_RS19595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C8250_RS19600	COG2366	antibiotic biosynthetic process
C8250_RS19620	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C8250_RS19630	COG1970	mechanosensitive ion channel activity
C8250_RS19670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C8250_RS19670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C8250_RS19675	COG1105	Belongs to the carbohydrate kinase PfkB family
C8250_RS19680	COG1349	DNA-binding transcription factor activity
C8250_RS19710	COG1846	Transcriptional regulator
C8250_RS19715	COG1764	response to oxidative stress
C8250_RS19720	COG1846	Transcriptional regulator
C8250_RS19795	COG1686	Belongs to the peptidase S11 family
C8250_RS19820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8250_RS19840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C8250_RS19915	COG1024	Enoyl-CoA hydratase
C8250_RS19935	COG0515	serine threonine protein kinase
C8250_RS19935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8250_RS19940	COG1309	transcriptional regulator
C8250_RS19950	COG1960	acyl-CoA dehydrogenase activity
C8250_RS19960	COG0183	Belongs to the thiolase family
C8250_RS19995	COG1024	Enoyl-CoA hydratase
C8250_RS20000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C8250_RS20010	COG4977	sequence-specific DNA binding
C8250_RS20020	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS20025	COG1960	acyl-CoA dehydrogenase activity
C8250_RS20030	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS20045	COG1960	acyl-CoA dehydrogenase activity
C8250_RS20050	COG1960	acyl-CoA dehydrogenase activity
C8250_RS20060	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS20070	COG1366	Belongs to the anti-sigma-factor antagonist family
C8250_RS20095	COG1216	Glycosyl transferase, family 2
C8250_RS20165	COG1131	(ABC) transporter
C8250_RS20210	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C8250_RS20245	COG1674	ftsk spoiiie
C8250_RS20275	COG2945	thiolester hydrolase activity
C8250_RS20275	COG0596	Alpha beta hydrolase
C8250_RS20285	COG4821	SIS domain
C8250_RS20295	COG0259	pyridoxamine-phosphate oxidase activity
C8250_RS20305	COG0247	lactate metabolic process
C8250_RS20305	COG0277	FAD linked oxidase domain protein
C8250_RS20310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C8250_RS20325	COG0667	Aldo Keto reductase
C8250_RS20350	COG2252	PERMEase
C8250_RS20360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C8250_RS20370	COG0477	Major facilitator Superfamily
C8250_RS20375	COG1846	Transcriptional regulator
C8250_RS20390	COG2814	Major facilitator Superfamily
C8250_RS20400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C8250_RS20405	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C8250_RS20410	COG1278	Cold shock
C8250_RS20440	COG1061	Type III restriction enzyme res subunit
C8250_RS20455	COG3973	AAA domain
C8250_RS20460	COG0745	RESPONSE REGULATOR receiver
C8250_RS20465	COG5002	protein histidine kinase activity
C8250_RS20495	COG1737	Transcriptional regulator
C8250_RS20500	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C8250_RS20505	COG0459	protein refolding
C8250_RS20510	COG1278	Cold shock
C8250_RS20525	COG0463	Glycosyl transferase, family 2
C8250_RS20560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C8250_RS20580	COG0649	NAD binding
C8250_RS20595	COG1174	glycine betaine transport
C8250_RS20605	COG1125	glycine betaine transport
C8250_RS20605	COG0517	IMP dehydrogenase activity
C8250_RS20610	COG2897	thiosulfate sulfurtransferase activity
C8250_RS20625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C8250_RS20630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C8250_RS20655	COG0302	gtp cyclohydrolase
C8250_RS20670	COG0037	tRNA processing
C8250_RS20680	COG2027	D-alanyl-D-alanine carboxypeptidase
C8250_RS20685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C8250_RS20695	COG0586	Pfam SNARE associated Golgi protein
C8250_RS20705	COG0393	Putative heavy-metal-binding
C8250_RS20710	COG0789	Transcriptional regulator
C8250_RS20720	COG0076	glutamate decarboxylase activity
C8250_RS20750	COG1077	Cell shape determining protein MreB Mrl
C8250_RS20765	COG0739	heme binding
C8250_RS20770	COG3360	Dodecin
C8250_RS20825	COG0671	phosphoesterase, PA-phosphatase related
C8250_RS20850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C8250_RS20855	COG2197	response regulator
C8250_RS20870	COG1595	DNA-templated transcription, initiation
C8250_RS20890	COG0667	Aldo Keto reductase
C8250_RS20900	COG1522	sequence-specific DNA binding
C8250_RS20935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C8250_RS20950	COG0579	oxidoreductase
C8250_RS20955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C8250_RS21020	COG0681	Belongs to the peptidase S26 family
C8250_RS21035	COG0739	heme binding
C8250_RS21035	COG0741	lytic transglycosylase activity
C8250_RS21035	COG1196	nuclear chromosome segregation
C8250_RS21055	COG0438	transferase activity, transferring glycosyl groups
C8250_RS21065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C8250_RS21125	COG0513	Belongs to the DEAD box helicase family
C8250_RS21155	COG1643	Atp-dependent helicase
C8250_RS21175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C8250_RS21185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C8250_RS21225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C8250_RS21230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C8250_RS21235	COG0047	phosphoribosylformylglycinamidine synthase activity
C8250_RS21240	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C8250_RS21275	COG2197	response regulator
C8250_RS21285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C8250_RS21300	COG0151	Belongs to the GarS family
C8250_RS21320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C8250_RS21330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C8250_RS21340	COG2124	cytochrome p450
C8250_RS21345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C8250_RS21370	COG0003	Pfam Anion-transporting ATPase
C8250_RS21380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C8250_RS21385	COG1610	YqeY-like protein
C8250_RS21400	COG1408	metallophosphoesterase
C8250_RS21415	COG2226	methyltransferase
C8250_RS21420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C8250_RS21440	COG1595	DNA-templated transcription, initiation
C8250_RS21460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C8250_RS21465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C8250_RS21510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C8250_RS21540	COG1595	DNA-templated transcription, initiation
C8250_RS21545	COG0433	COG0433 Predicted ATPase
C8250_RS21560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C8250_RS21670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C8250_RS21735	COG1674	ftsk spoiiie
C8250_RS21785	COG1191	sigma factor activity
C8250_RS21790	COG1191	sigma factor activity
C8250_RS21805	COG0667	Aldo Keto reductase
C8250_RS21820	COG2353	YceI-like domain
C8250_RS21825	COG3467	pyridoxamine 5'-phosphate
C8250_RS21835	COG0477	Major facilitator Superfamily
C8250_RS21840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C8250_RS21850	COG2205	protein histidine kinase activity
C8250_RS21855	COG0745	RESPONSE REGULATOR receiver
C8250_RS21870	COG2315	Protein conserved in bacteria
C8250_RS21895	COG5000	phosphorelay sensor kinase activity
C8250_RS21900	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS21905	COG1595	DNA-templated transcription, initiation
C8250_RS21925	COG1960	acyl-CoA dehydrogenase activity
C8250_RS21935	COG1960	acyl-CoA dehydrogenase activity
C8250_RS21950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C8250_RS21970	COG2197	response regulator
C8250_RS21975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C8250_RS21990	COG0653	protein targeting
C8250_RS22010	COG0006	proline dipeptidase activity
C8250_RS22045	COG2372	response to copper ion
C8250_RS22050	COG2837	iron assimilation
C8250_RS22060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C8250_RS22065	COG0561	phosphatase activity
C8250_RS22070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8250_RS22080	COG2353	YceI-like domain
C8250_RS22090	COG2807	transmembrane transport
C8250_RS22110	COG1131	(ABC) transporter
C8250_RS22130	COG0789	Transcriptional regulator
C8250_RS22140	COG0561	phosphatase activity
C8250_RS22150	COG4988	ABC transporter
C8250_RS22155	COG1294	oxidase, subunit
C8250_RS22160	COG1271	oxidase subunit
C8250_RS22165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C8250_RS22170	COG1609	Transcriptional regulator
C8250_RS22195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C8250_RS22210	COG2268	Band 7 protein
C8250_RS22220	COG0662	Cupin 2, conserved barrel domain protein
C8250_RS22225	COG1950	PFAM Membrane protein of
C8250_RS22230	COG0626	cystathionine gamma-synthase activity
C8250_RS22280	COG0305	Participates in initiation and elongation during chromosome replication
C8250_RS22285	COG0534	Mate efflux family protein
C8250_RS22310	COG0359	binds to the 23S rRNA
C8250_RS22315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C8250_RS22320	COG0629	single-stranded DNA binding
C8250_RS22325	COG0360	Binds together with S18 to 16S ribosomal RNA
C8250_RS22350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C8250_RS22360	COG1260	myo-inositol-1-phosphate synthase
C8250_RS22375	COG0617	tRNA 3'-terminal CCA addition
C8250_RS22390	COG0515	serine threonine protein kinase
C8250_RS22390	COG2815	serine threonine protein kinase
C8250_RS22395	COG1595	DNA-templated transcription, initiation
C8250_RS22405	COG0492	ferredoxin-NADP+ reductase activity
C8250_RS22410	COG3118	belongs to the thioredoxin family
C8250_RS22425	COG1192	Involved in chromosome partitioning
C8250_RS22430	COG0357	Ribosomal RNA small subunit methyltransferase G
C8250_RS22440	COG0706	membrane insertase activity
C8250_RS22445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C8250_RS22450	COG0594	ribonuclease P activity
C8250_RS22455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C8250_RS22465	COG0592	DNA-directed DNA polymerase activity
C8250_RS22470	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C8250_RS22475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C8250_RS22480	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C8250_RS22490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C8250_RS22495	COG3266	domain, Protein
C8250_RS22520	COG0515	serine threonine protein kinase
C8250_RS22540	COG0477	Major facilitator Superfamily
C8250_RS22555	COG0705	Rhomboid family
C8250_RS22570	COG3764	Sortase (surface protein transpeptidase)
C8250_RS22585	COG3764	Sortase (surface protein transpeptidase)
C8250_RS22590	COG3764	Sortase (surface protein transpeptidase)
C8250_RS22595	COG0515	serine threonine protein kinase
C8250_RS22615	COG1716	ATPase activity
C8250_RS22620	COG1716	ATPase activity
C8250_RS22630	COG1024	Enoyl-CoA hydratase
C8250_RS22635	COG1960	acyl-CoA dehydrogenase activity
C8250_RS22640	COG1309	transcriptional regulator
C8250_RS22650	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
C8250_RS22680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C8250_RS22685	COG1733	regulation of RNA biosynthetic process
C8250_RS22715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8250_RS22720	COG2151	metal-sulfur cluster biosynthetic enzyme
C8250_RS22725	COG3396	Phenylacetate-CoA oxygenase
C8250_RS22730	COG3460	Phenylacetate-CoA oxygenase
C8250_RS22735	COG3396	Phenylacetate-CoA oxygenase
C8250_RS22760	COG1250	3-hydroxyacyl-CoA dehydrogenase
C8250_RS22765	COG1309	transcriptional regulator
C8250_RS22775	COG1522	sequence-specific DNA binding
C8250_RS22805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C8250_RS22810	COG0604	alcohol dehydrogenase
C8250_RS22810	COG3321	synthase
C8250_RS22810	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS22825	COG4591	ABC-type transport system involved in lipoprotein release permease component
C8250_RS22825	COG1136	(ABC) transporter
C8250_RS22840	COG0515	serine threonine protein kinase
C8250_RS22845	COG0515	serine threonine protein kinase
C8250_RS22870	COG0022	dehydrogenase e1 component
C8250_RS22875	COG0508	dehydrogenase complex catalyzes the overall conversion of
C8250_RS22885	COG1802	Transcriptional regulator
C8250_RS22890	COG2814	Major facilitator Superfamily
C8250_RS22900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8250_RS22905	COG2755	lipolytic protein G-D-S-L family
C8250_RS22925	COG1362	aminopeptidase activity
C8250_RS22930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C8250_RS22940	COG1960	acyl-CoA dehydrogenase activity
C8250_RS22960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C8250_RS22965	COG2337	Toxic component of a toxin-antitoxin (TA) module
C8250_RS22975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C8250_RS22995	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS23010	COG0531	amino acid
C8250_RS23075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C8250_RS23130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C8250_RS23135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C8250_RS23140	COG0598	Magnesium transport protein CorA
C8250_RS23160	COG1191	sigma factor activity
C8250_RS23175	COG2304	oxidoreductase activity
C8250_RS23215	COG0438	transferase activity, transferring glycosyl groups
C8250_RS23220	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C8250_RS23235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C8250_RS23240	COG0438	transferase activity, transferring glycosyl groups
C8250_RS23285	COG2378	regulation of single-species biofilm formation
C8250_RS23310	COG3629	intracellular signal transduction
C8250_RS23310	COG3903	Transcriptional regulator
C8250_RS23350	COG2197	response regulator
C8250_RS23355	COG4585	Histidine kinase
C8250_RS23390	COG0717	Belongs to the dCTP deaminase family
C8250_RS23425	COG2181	nitrate reductase activity
C8250_RS23425	COG0247	lactate metabolic process
C8250_RS23435	COG0443	Heat shock 70 kDa protein
C8250_RS23440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C8250_RS23445	COG0484	heat shock protein binding
C8250_RS23450	COG0789	Transcriptional regulator
C8250_RS23490	COG0443	Heat shock 70 kDa protein
C8250_RS23500	COG0542	response to heat
C8250_RS23535	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C8250_RS23550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C8250_RS23555	COG0191	fructose-bisphosphate aldolase activity
C8250_RS23575	COG3844	kynureninase activity
C8250_RS23590	COG2197	response regulator
C8250_RS23615	COG0596	Alpha beta hydrolase
C8250_RS23625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C8250_RS23630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C8250_RS23695	COG1111	helicase
C8250_RS23695	COG1205	dead DEAH box helicase
C8250_RS23700	COG1366	Belongs to the anti-sigma-factor antagonist family
C8250_RS23705	COG2172	sigma factor antagonist activity
C8250_RS23710	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C8250_RS23720	COG2890	protein-(glutamine-N5) methyltransferase activity
C8250_RS23740	COG0640	Transcriptional regulator
C8250_RS23755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C8250_RS23755	COG1754	DNA topoisomerase type I activity
C8250_RS23760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C8250_RS23785	COG1252	NADH dehydrogenase
C8250_RS23830	COG4209	transmembrane transport
C8250_RS23835	COG0395	ABC-type sugar transport system, permease component
C8250_RS23845	COG1609	Transcriptional regulator
C8250_RS23880	COG0741	lytic transglycosylase activity
C8250_RS23880	COG1196	nuclear chromosome segregation
C8250_RS23880	COG0739	heme binding
C8250_RS23885	COG0671	phosphoesterase, PA-phosphatase related
C8250_RS23890	COG0277	FAD linked oxidase domain protein
C8250_RS23910	COG1937	Protein conserved in bacteria
C8250_RS23920	COG0306	phosphate transporter
C8250_RS23945	COG0494	nUDIX hydrolase
C8250_RS23945	COG0406	alpha-ribazole phosphatase activity
C8250_RS23960	COG0456	acetyltransferase
C8250_RS23965	COG2271	Major facilitator Superfamily
C8250_RS23970	COG0737	Belongs to the 5'-nucleotidase family
C8250_RS23985	COG0745	RESPONSE REGULATOR receiver
C8250_RS23995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C8250_RS24000	COG1609	Transcriptional regulator
C8250_RS24005	COG0745	RESPONSE REGULATOR receiver
C8250_RS24030	COG2897	thiosulfate sulfurtransferase activity
C8250_RS24060	COG3485	protocatechuate 3,4-dioxygenase
C8250_RS24070	COG0354	folic acid binding
C8250_RS24075	COG1490	D-aminoacyl-tRNA deacylase activity
C8250_RS24090	COG4552	Acetyltransferase involved in intracellular survival and related
C8250_RS24120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C8250_RS24130	COG2318	DinB family
C8250_RS24145	COG4941	Belongs to the sigma-70 factor family
C8250_RS24180	COG0438	transferase activity, transferring glycosyl groups
C8250_RS24200	COG0588	phosphoglycerate mutase activity
C8250_RS24210	COG5002	protein histidine kinase activity
C8250_RS24225	COG1329	Transcriptional regulator
C8250_RS24230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C8250_RS24235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C8250_RS24240	COG0215	cysteine-tRNA ligase activity
C8250_RS24245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C8250_RS24265	COG3842	ATPase activity
C8250_RS24275	COG0596	Alpha beta hydrolase
C8250_RS24285	COG1136	(ABC) transporter
C8250_RS24285	COG0577	efflux transmembrane transporter activity
C8250_RS24290	COG0577	efflux transmembrane transporter activity
C8250_RS24290	COG1136	(ABC) transporter
C8250_RS24305	COG0745	RESPONSE REGULATOR receiver
C8250_RS24310	COG2205	protein histidine kinase activity
C8250_RS24335	COG2197	response regulator
C8250_RS24355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C8250_RS24375	COG2197	response regulator
C8250_RS24395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C8250_RS24400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C8250_RS24410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C8250_RS24430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C8250_RS24460	COG0739	heme binding
C8250_RS24460	COG1196	nuclear chromosome segregation
C8250_RS24460	COG0741	lytic transglycosylase activity
C8250_RS24475	COG2205	protein histidine kinase activity
C8250_RS24480	COG0745	RESPONSE REGULATOR receiver
C8250_RS24490	COG1595	DNA-templated transcription, initiation
C8250_RS24495	COG1194	a g-specific adenine glycosylase
C8250_RS24505	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C8250_RS24525	COG0248	Ppx GppA phosphatase
C8250_RS24530	COG1082	Xylose isomerase domain protein TIM barrel
C8250_RS24535	COG1309	transcriptional regulator
C8250_RS24540	COG0129	dihydroxy-acid dehydratase activity
C8250_RS24560	COG1129	ABC transporter
C8250_RS24560	COG0842	Transport permease protein
C8250_RS24570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C8250_RS24575	COG0180	Tryptophanyl-tRNA synthetase
C8250_RS24595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C8250_RS24605	COG0123	including yeast histone deacetylase and acetoin utilization protein
C8250_RS24660	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C8250_RS24665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C8250_RS24670	COG0181	hydroxymethylbilane synthase activity
C8250_RS24675	COG1648	precorrin-2 dehydrogenase activity
C8250_RS24675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C8250_RS24680	COG0113	porphobilinogen synthase activity
C8250_RS24710	COG0018	arginyl-trna synthetase
C8250_RS24715	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C8250_RS24735	COG1690	Belongs to the RtcB family
C8250_RS24755	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C8250_RS24775	COG1649	PFAM Uncharacterised BCR, COG1649
C8250_RS24790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C8250_RS24795	COG0406	alpha-ribazole phosphatase activity
C8250_RS24815	COG1333	cytochrome c biogenesis protein
C8250_RS24820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C8250_RS24830	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C8250_RS24850	COG0163	prenyltransferase activity
C8250_RS24860	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C8250_RS24875	COG1301	dicarboxylic acid transport
C8250_RS24880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C8250_RS24905	COG1309	transcriptional regulator
C8250_RS24945	COG1278	Cold shock
C8250_RS24950	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C8250_RS24955	COG1674	ftsk spoiiie
C8250_RS24980	COG0515	serine threonine protein kinase
C8250_RS24980	COG2815	serine threonine protein kinase
C8250_RS24995	COG0714	Associated with various cellular activities
C8250_RS25005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C8250_RS25035	COG1136	(ABC) transporter
C8250_RS25045	COG2226	methyltransferase
C8250_RS25060	COG2207	Transcriptional regulator
C8250_RS25110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C8250_RS25115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C8250_RS25120	COG0649	NAD binding
C8250_RS25130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C8250_RS25135	COG1034	ATP synthesis coupled electron transport
C8250_RS25140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C8250_RS25145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C8250_RS25155	COG0713	ATP synthesis coupled electron transport
C8250_RS25160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C8250_RS25170	COG1007	ATP synthesis coupled electron transport
C8250_RS25180	COG0142	geranyltranstransferase activity
C8250_RS25240	COG0702	epimerase
C8250_RS25245	COG1733	regulation of RNA biosynthetic process
C8250_RS25250	COG1013	pyruvate-flavodoxin oxidoreductase activity
C8250_RS25255	COG0674	pyruvate-flavodoxin oxidoreductase activity
C8250_RS25255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C8250_RS25265	COG4585	Histidine kinase
C8250_RS25275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C8250_RS25280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C8250_RS25290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C8250_RS25295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C8250_RS25300	COG0839	Belongs to the complex I subunit 6 family
C8250_RS25305	COG0713	ATP synthesis coupled electron transport
C8250_RS25320	COG1007	ATP synthesis coupled electron transport
C8250_RS25325	COG0501	Belongs to the peptidase M48B family
C8250_RS25330	COG3304	Inner membrane component domain
C8250_RS25345	COG1609	Transcriptional regulator
C8250_RS25345	COG2207	Transcriptional regulator
C8250_RS25350	COG1666	GTP binding
C8250_RS25380	COG0702	epimerase
C8250_RS25400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C8250_RS25405	COG2030	dehydratase
C8250_RS25420	COG0477	Major facilitator Superfamily
C8250_RS25425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C8250_RS25440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C8250_RS25445	COG0436	Aminotransferase
C8250_RS25465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C8250_RS25470	COG0081	regulation of translation
C8250_RS25475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C8250_RS25480	COG0222	ribosome binding
C8250_RS25485	COG0085	RNA polymerase activity
C8250_RS25490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C8250_RS25500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C8250_RS25505	COG0049	tRNA binding
C8250_RS25510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C8250_RS25515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C8250_RS25540	COG0051	transcription antitermination factor activity, RNA binding
C8250_RS25545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C8250_RS25550	COG0088	Forms part of the polypeptide exit tunnel
C8250_RS25555	COG0089	rRNA binding
C8250_RS25560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C8250_RS25565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C8250_RS25570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C8250_RS25575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C8250_RS25580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C8250_RS25585	COG0255	Belongs to the universal ribosomal protein uL29 family
C8250_RS25590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C8250_RS25595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C8250_RS25600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C8250_RS25605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C8250_RS25610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C8250_RS25615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C8250_RS25620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C8250_RS25625	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C8250_RS25630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C8250_RS25640	COG0200	Binds to the 23S rRNA
C8250_RS25650	COG0563	adenylate kinase activity
C8250_RS25660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C8250_RS25665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C8250_RS25670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C8250_RS25675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C8250_RS25680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C8250_RS25690	COG0203	ribosomal protein L17
C8250_RS25695	COG0101	tRNA pseudouridine synthase activity
C8250_RS25710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C8250_RS25715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C8250_RS25720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C8250_RS25725	COG1072	(Pantothenic acid kinase))
C8250_RS25730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C8250_RS25735	COG0736	holo-[acyl-carrier-protein] synthase activity
C8250_RS25745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C8250_RS25755	COG0802	atpase or kinase
C8250_RS25780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C8250_RS25790	COG0726	polysaccharide deacetylase
C8250_RS25795	COG0515	serine threonine protein kinase
C8250_RS25795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8250_RS25805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C8250_RS25810	COG0459	protein refolding
C8250_RS25820	COG4221	oxidoreductase activity
C8250_RS25825	COG2258	MOSC domain
C8250_RS25840	COG0583	DNA-binding transcription factor activity
C8250_RS25855	COG1595	DNA-templated transcription, initiation
C8250_RS25865	COG0516	GMP reductase activity
C8250_RS25880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C8250_RS25885	COG2815	serine threonine protein kinase
C8250_RS25885	COG0515	serine threonine protein kinase
C8250_RS25905	COG0515	serine threonine protein kinase
C8250_RS25905	COG2815	serine threonine protein kinase
C8250_RS25910	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS25925	COG0519	Catalyzes the synthesis of GMP from XMP
C8250_RS25925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C8250_RS25950	COG2197	response regulator
C8250_RS25955	COG0791	NLP P60 protein
C8250_RS25970	COG0714	Associated with various cellular activities
C8250_RS26000	COG0739	heme binding
C8250_RS26010	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C8250_RS26010	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C8250_RS26025	COG0714	Associated with various cellular activities
C8250_RS26035	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C8250_RS26040	COG0045	succinate-CoA ligase (ADP-forming) activity
C8250_RS26065	COG0138	bifunctional purine biosynthesis protein purh
C8250_RS26075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C8250_RS26085	COG0039	L-malate dehydrogenase activity
C8250_RS26100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8250_RS26105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C8250_RS26115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C8250_RS26120	COG0180	Tryptophanyl-tRNA synthetase
C8250_RS26145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C8250_RS26155	COG1295	ribonuclease BN
C8250_RS26160	COG1686	Belongs to the peptidase S11 family
C8250_RS26170	COG1408	metallophosphoesterase
C8250_RS26175	COG1309	transcriptional regulator
C8250_RS26190	COG2409	Drug exporters of the RND superfamily
C8250_RS26195	COG0745	RESPONSE REGULATOR receiver
C8250_RS26205	COG2205	protein histidine kinase activity
C8250_RS26240	COG1053	succinate dehydrogenase
C8250_RS26250	COG2009	succinate dehydrogenase
C8250_RS26260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C8250_RS26290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C8250_RS26290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C8250_RS26305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C8250_RS26315	COG1216	Glycosyl transferase, family 2
C8250_RS26330	COG2089	acid synthase
C8250_RS26340	COG1473	amidohydrolase
C8250_RS26340	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C8250_RS26345	COG1744	ABC transporter substrate-binding protein PnrA-like
C8250_RS26350	COG3845	ABC transporter
C8250_RS26355	COG4603	Belongs to the binding-protein-dependent transport system permease family
C8250_RS26360	COG1079	Belongs to the binding-protein-dependent transport system permease family
C8250_RS26400	COG2814	Major facilitator Superfamily
C8250_RS26405	COG0583	DNA-binding transcription factor activity
C8250_RS26415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C8250_RS26445	COG2205	protein histidine kinase activity
C8250_RS26450	COG0745	RESPONSE REGULATOR receiver
C8250_RS26455	COG1595	DNA-templated transcription, initiation
C8250_RS26480	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS26495	COG1609	Transcriptional regulator
C8250_RS26545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C8250_RS26550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C8250_RS26570	COG1349	DNA-binding transcription factor activity
C8250_RS26585	COG4770	biotin carboxylase activity
C8250_RS26595	COG0424	maF-like protein
C8250_RS26610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C8250_RS26620	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C8250_RS26625	COG1024	Enoyl-CoA hydratase
C8250_RS26635	COG2986	histidine ammonia-lyase
C8250_RS26675	COG1136	(ABC) transporter
C8250_RS26700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C8250_RS26735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C8250_RS26750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C8250_RS26760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C8250_RS26780	COG1331	Highly conserved protein containing a thioredoxin domain
C8250_RS26790	COG0477	Major facilitator Superfamily
C8250_RS26800	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C8250_RS26815	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C8250_RS26830	COG1414	Transcriptional regulator
C8250_RS26835	COG0251	oxidation-reduction process
C8250_RS26840	COG2610	gluconate transmembrane transporter activity
C8250_RS26885	COG2894	cell division
C8250_RS26930	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS26955	COG0667	Aldo Keto reductase
C8250_RS26960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C8250_RS26965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C8250_RS26980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C8250_RS26985	COG0450	alkyl hydroperoxide reductase
C8250_RS27000	COG1136	(ABC) transporter
C8250_RS27030	COG2226	methyltransferase
C8250_RS27040	COG0114	fumarate hydratase activity
C8250_RS27050	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C8250_RS27050	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C8250_RS27075	COG0778	Nitroreductase
C8250_RS27080	COG1722	exodeoxyribonuclease VII activity
C8250_RS27085	COG1570	exodeoxyribonuclease VII activity
C8250_RS27095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C8250_RS27110	COG0012	GTP binding
C8250_RS27115	COG4115	mRNA cleavage
C8250_RS27120	COG2161	toxin-antitoxin pair type II binding
C8250_RS27125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C8250_RS27155	COG1716	ATPase activity
C8250_RS27155	COG0842	Transport permease protein
C8250_RS27155	COG1131	(ABC) transporter
C8250_RS27180	COG2208	phosphoserine phosphatase activity
C8250_RS27180	COG2770	Histidine kinase
C8250_RS27205	COG0698	ribose 5-phosphate isomerase
C8250_RS27230	COG1842	Phage shock protein A
C8250_RS27245	COG1053	succinate dehydrogenase
C8250_RS27265	COG1217	gtp-binding protein TYPA
C8250_RS27275	COG0346	lactoylglutathione lyase activity
C8250_RS27280	COG4166	transmembrane transport
C8250_RS27290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS27300	COG4608	Belongs to the ABC transporter superfamily
C8250_RS27315	COG0601	transmembrane transport
C8250_RS27320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS27330	COG4608	Belongs to the ABC transporter superfamily
C8250_RS27335	COG4608	Belongs to the ABC transporter superfamily
C8250_RS27340	COG0444	Belongs to the ABC transporter superfamily
C8250_RS27350	COG4166	transmembrane transport
C8250_RS27355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS27375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C8250_RS27390	COG1131	(ABC) transporter
C8250_RS27400	COG4585	Histidine kinase
C8250_RS27405	COG2409	Drug exporters of the RND superfamily
C8250_RS27410	COG2197	response regulator
C8250_RS27420	COG0456	acetyltransferase
C8250_RS27420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C8250_RS27445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C8250_RS27455	COG1611	Belongs to the LOG family
C8250_RS27460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C8250_RS27470	COG0519	Catalyzes the synthesis of GMP from XMP
C8250_RS27475	COG1024	Enoyl-CoA hydratase
C8250_RS27490	COG1595	DNA-templated transcription, initiation
C8250_RS27500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C8250_RS27505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C8250_RS27545	COG0598	Magnesium transport protein CorA
C8250_RS27565	COG2095	MarC family integral membrane protein
C8250_RS27575	COG1432	Conserved Protein
C8250_RS27615	COG2267	carboxylic ester hydrolase activity
C8250_RS27630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS27635	COG0601	transmembrane transport
C8250_RS27670	COG0596	Alpha beta hydrolase
C8250_RS27730	COG0210	DNA helicase
C8250_RS27735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C8250_RS27775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C8250_RS27830	COG3480	Lon protease (S16) C-terminal proteolytic domain
C8250_RS27840	COG1615	UPF0182 protein
C8250_RS27870	COG0753	catalase activity
C8250_RS27880	COG0483	inositol monophosphate 1-phosphatase activity
C8250_RS27890	COG0477	Major facilitator Superfamily
C8250_RS27905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C8250_RS27915	COG2135	peptidase activity
C8250_RS27925	COG1595	DNA-templated transcription, initiation
C8250_RS27930	COG5662	AntiSigma factor
C8250_RS27935	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C8250_RS27935	COG2199	diguanylate cyclase activity
C8250_RS27955	COG0242	peptide deformylase activity
C8250_RS27960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C8250_RS27995	COG2188	Transcriptional regulator
C8250_RS28000	COG2182	Extracellular solute-binding protein
C8250_RS28005	COG1175	transmembrane transport
C8250_RS28010	COG0395	ABC-type sugar transport system, permease component
C8250_RS28015	COG1472	Belongs to the glycosyl hydrolase 3 family
C8250_RS28020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C8250_RS28035	COG1597	lipid kinase activity
C8250_RS28060	COG1116	anion transmembrane transporter activity
C8250_RS28065	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C8250_RS28070	COG1737	Transcriptional regulator
C8250_RS28090	COG4106	trans-aconitate 2-methyltransferase activity
C8250_RS28095	COG1126	abc transporter atp-binding protein
C8250_RS28100	COG0765	amino acid transport
C8250_RS28105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8250_RS28110	COG0281	malic enzyme
C8250_RS28120	COG1595	DNA-templated transcription, initiation
C8250_RS28125	COG0604	alcohol dehydrogenase
C8250_RS28165	COG0641	radical SAM
C8250_RS28180	COG0567	Dehydrogenase, E1 component
C8250_RS28180	COG0508	dehydrogenase complex catalyzes the overall conversion of
C8250_RS28185	COG2205	protein histidine kinase activity
C8250_RS28190	COG0745	RESPONSE REGULATOR receiver
C8250_RS28195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C8250_RS28275	COG2843	Capsule synthesis protein
C8250_RS28300	COG0386	Belongs to the glutathione peroxidase family
C8250_RS28335	COG3321	synthase
C8250_RS28335	COG0604	alcohol dehydrogenase
C8250_RS28340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8250_RS28375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C8250_RS28385	COG3251	PFAM MbtH domain protein
C8250_RS28410	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS28420	COG3629	intracellular signal transduction
C8250_RS28420	COG3903	Transcriptional regulator
C8250_RS28435	COG2211	Major facilitator Superfamily
C8250_RS28445	COG0154	amidase activity
C8250_RS28460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C8250_RS28465	COG2226	methyltransferase
C8250_RS28470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8250_RS28480	COG0604	alcohol dehydrogenase
C8250_RS28480	COG3321	synthase
C8250_RS28490	COG0604	alcohol dehydrogenase
C8250_RS28490	COG3321	synthase
C8250_RS28500	COG1131	(ABC) transporter
C8250_RS28510	COG2267	carboxylic ester hydrolase activity
C8250_RS28545	COG0019	diaminopimelate decarboxylase activity
C8250_RS28550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C8250_RS28565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C8250_RS28580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C8250_RS28585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8250_RS28590	COG0646	methionine synthase
C8250_RS28590	COG1410	methionine synthase
C8250_RS28600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C8250_RS28620	COG0018	arginyl-trna synthetase
C8250_RS28625	COG0019	diaminopimelate decarboxylase activity
C8250_RS28630	COG0460	homoserine dehydrogenase
C8250_RS28635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C8250_RS28640	COG0083	homoserine kinase activity
C8250_RS28655	COG0254	rRNA binding
C8250_RS28660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C8250_RS28665	COG2890	protein-(glutamine-N5) methyltransferase activity
C8250_RS28680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C8250_RS28685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C8250_RS28700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C8250_RS28705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C8250_RS28710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C8250_RS28715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C8250_RS28720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C8250_RS28725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C8250_RS28730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C8250_RS28745	COG2197	response regulator
C8250_RS28750	COG4585	Histidine kinase
C8250_RS28780	COG1250	3-hydroxyacyl-CoA dehydrogenase
C8250_RS28790	COG1660	Displays ATPase and GTPase activities
C8250_RS28970	COG1302	Protein conserved in bacteria
C8250_RS28990	COG0484	heat shock protein binding
C8250_RS29130	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C8250_RS29180	COG0183	Belongs to the thiolase family
C8250_RS29250	COG1595	DNA-templated transcription, initiation
C8250_RS29275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C8250_RS29275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C8250_RS29290	COG2205	protein histidine kinase activity
C8250_RS29295	COG0745	RESPONSE REGULATOR receiver
C8250_RS29300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C8250_RS29305	COG1088	dTDP-glucose 4,6-dehydratase activity
C8250_RS29340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C8250_RS29345	COG0280	phosphate acetyltransferase
C8250_RS29345	COG0857	belongs to the CobB CobQ family
C8250_RS29360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C8250_RS29365	COG0205	6-phosphofructokinase activity
C8250_RS29385	COG3469	chitinase activity
C8250_RS29390	COG3290	protein histidine kinase activity
C8250_RS29395	COG1301	dicarboxylic acid transport
C8250_RS29415	COG3281	Trehalose synthase
C8250_RS29425	COG0366	Alpha amylase catalytic
C8250_RS29460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C8250_RS29465	COG0058	SHG alpha-glucan phosphorylase activity
C8250_RS29470	COG0513	Belongs to the DEAD box helicase family
C8250_RS29475	COG1278	Cold shock
C8250_RS29485	COG1132	(ABC) transporter
C8250_RS29490	COG1132	(ABC) transporter
C8250_RS29505	COG1376	ErfK ybiS ycfS ynhG family protein
C8250_RS29510	COG1376	ErfK ybiS ycfS ynhG family protein
C8250_RS29545	COG1169	isochorismate synthase
C8250_RS29555	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C8250_RS29560	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C8250_RS29580	COG2814	Major facilitator Superfamily
C8250_RS29610	COG1760	l-serine dehydratase
C8250_RS29615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C8250_RS29620	COG0509	glycine decarboxylation via glycine cleavage system
C8250_RS29625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C8250_RS29660	COG0747	negative chemotaxis
C8250_RS29665	COG0601	transmembrane transport
C8250_RS29675	COG4608	Belongs to the ABC transporter superfamily
C8250_RS29685	COG2860	membrane
C8250_RS29705	COG0482	sulfurtransferase activity
C8250_RS29710	COG1611	Belongs to the LOG family
C8250_RS29715	COG4221	oxidoreductase activity
C8250_RS29725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C8250_RS29735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C8250_RS29740	COG0154	amidase activity
C8250_RS29750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C8250_RS29755	COG2409	Drug exporters of the RND superfamily
C8250_RS29775	COG2197	response regulator
C8250_RS29785	COG2133	pyrroloquinoline quinone binding
C8250_RS29810	COG0440	acetolactate synthase activity
C8250_RS29815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C8250_RS29820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C8250_RS29830	COG3835	regulator
C8250_RS29840	COG0506	proline dehydrogenase activity
C8250_RS29845	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS29855	COG0473	3-isopropylmalate dehydrogenase activity
C8250_RS29860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C8250_RS29875	COG0804	urea catabolic process
C8250_RS29880	COG2957	Belongs to the agmatine deiminase family
C8250_RS29885	COG1309	transcriptional regulator
C8250_RS29895	COG0477	Major facilitator Superfamily
C8250_RS29900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C8250_RS29945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C8250_RS29955	COG5492	domain, Protein
C8250_RS29965	COG2301	Belongs to the HpcH HpaI aldolase family
C8250_RS29975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C8250_RS29995	COG2018	Roadblock/LC7 domain
C8250_RS30015	COG2018	Roadblock/LC7 domain
C8250_RS30030	COG0179	Fumarylacetoacetate (FAA) hydrolase
C8250_RS30035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C8250_RS30080	COG1414	Transcriptional regulator
C8250_RS30085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C8250_RS30090	COG0066	3-isopropylmalate dehydratase activity
C8250_RS30100	COG0776	regulation of translation
C8250_RS30110	COG1920	GTP binding
C8250_RS30120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C8250_RS30125	COG1181	Belongs to the D-alanine--D-alanine ligase family
C8250_RS30145	COG0351	phosphomethylpyrimidine kinase
C8250_RS30150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C8250_RS30155	COG1461	Dihydroxyacetone kinase
C8250_RS30160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C8250_RS30170	COG0742	ribosomal rna small subunit methyltransferase
C8250_RS30175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C8250_RS30190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C8250_RS30195	COG0571	ribonuclease III activity
C8250_RS30200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C8250_RS30205	COG1733	regulation of RNA biosynthetic process
C8250_RS30210	COG2340	Cysteine-rich secretory protein family
C8250_RS30215	COG1254	Belongs to the acylphosphatase family
C8250_RS30230	COG0477	Major facilitator Superfamily
C8250_RS30265	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C8250_RS30300	COG0442	prolyl-tRNA aminoacylation
C8250_RS30310	COG0228	four-way junction DNA binding
C8250_RS30315	COG1837	Belongs to the UPF0109 family
C8250_RS30320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C8250_RS30325	COG0336	Belongs to the RNA methyltransferase TrmD family
C8250_RS30330	COG0335	large ribosomal subunit rRNA binding
C8250_RS30340	COG0681	Belongs to the peptidase S26 family
C8250_RS30345	COG0681	Belongs to the peptidase S26 family
C8250_RS30350	COG0681	Belongs to the peptidase S26 family
C8250_RS30365	COG0792	nuclease activity
C8250_RS30380	COG1191	sigma factor activity
C8250_RS30395	COG0052	Belongs to the universal ribosomal protein uS2 family
C8250_RS30400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C8250_RS30405	COG0528	UMP kinase activity
C8250_RS30410	COG0233	cytoplasmic translational termination
C8250_RS30415	COG0575	Belongs to the CDS family
C8250_RS30420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C8250_RS30430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C8250_RS30435	COG3842	ATPase activity
C8250_RS30450	COG1136	(ABC) transporter
C8250_RS30450	COG0577	efflux transmembrane transporter activity
C8250_RS30455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C8250_RS30465	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS30480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C8250_RS30505	COG3842	ATPase activity
C8250_RS30510	COG1176	ABC-type spermidine putrescine transport system, permease component I
C8250_RS30515	COG1177	transmembrane transport
C8250_RS30520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8250_RS30550	COG2508	Transcriptional regulator
C8250_RS30555	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS30565	COG1595	DNA-templated transcription, initiation
C8250_RS30585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C8250_RS30590	COG0750	zinc metalloprotease
C8250_RS30595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C8250_RS30610	COG0442	prolyl-tRNA aminoacylation
C8250_RS30615	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
C8250_RS30630	COG0779	Required for maturation of 30S ribosomal subunits
C8250_RS30645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C8250_RS30655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C8250_RS30660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C8250_RS30680	COG2197	response regulator
C8250_RS30685	COG4585	Histidine kinase
C8250_RS30695	COG1131	(ABC) transporter
C8250_RS30775	COG1404	Belongs to the peptidase S8 family
C8250_RS30795	COG1674	ftsk spoiiie
C8250_RS30805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C8250_RS30810	COG1185	polyribonucleotide nucleotidyltransferase activity
C8250_RS30815	COG0612	Peptidase, M16
C8250_RS30820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C8250_RS30840	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C8250_RS30845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C8250_RS30850	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C8250_RS30880	COG2208	phosphoserine phosphatase activity
C8250_RS30880	COG2770	Histidine kinase
C8250_RS30885	COG0784	Response regulator, receiver
C8250_RS30885	COG2205	protein histidine kinase activity
C8250_RS30895	COG1674	ftsk spoiiie
C8250_RS30905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C8250_RS30915	COG1058	Belongs to the CinA family
C8250_RS30915	COG1546	Belongs to the CinA family
C8250_RS30920	COG1396	sequence-specific DNA binding
C8250_RS30925	COG0783	Belongs to the Dps family
C8250_RS30930	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS30935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C8250_RS30940	COG1201	RNA secondary structure unwinding
C8250_RS30945	COG1917	Cupin 2, conserved barrel domain protein
C8250_RS30945	COG2207	Transcriptional regulator
C8250_RS30980	COG0628	permease
C8250_RS30985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C8250_RS30995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C8250_RS31000	COG0765	amino acid transport
C8250_RS31005	COG0765	amino acid transport
C8250_RS31010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8250_RS31015	COG1126	abc transporter atp-binding protein
C8250_RS31020	COG0745	RESPONSE REGULATOR receiver
C8250_RS31025	COG2205	protein histidine kinase activity
C8250_RS31030	COG0515	serine threonine protein kinase
C8250_RS31040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C8250_RS31060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C8250_RS31070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C8250_RS31075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C8250_RS31085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C8250_RS31120	COG2815	serine threonine protein kinase
C8250_RS31120	COG0515	serine threonine protein kinase
C8250_RS31130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C8250_RS31135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C8250_RS31140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C8250_RS31145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C8250_RS31150	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C8250_RS31185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C8250_RS31200	COG0514	ATP-dependent DNA helicase (RecQ)
C8250_RS31225	COG1131	(ABC) transporter
C8250_RS31235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C8250_RS31250	COG0187	DNA topoisomerase II activity
C8250_RS31260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8250_RS31265	COG4565	transcriptional regulatory protein
C8250_RS31270	COG3290	protein histidine kinase activity
C8250_RS31280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C8250_RS31285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C8250_RS31295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C8250_RS31300	COG0612	Peptidase, M16
C8250_RS31315	COG1802	Transcriptional regulator
C8250_RS31320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C8250_RS31340	COG1435	thymidine kinase activity
C8250_RS31375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C8250_RS31380	COG0483	inositol monophosphate 1-phosphatase activity
C8250_RS31395	COG0745	RESPONSE REGULATOR receiver
C8250_RS31400	COG2205	protein histidine kinase activity
C8250_RS31420	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS31430	COG0756	dUTP diphosphatase activity
C8250_RS31445	COG1136	(ABC) transporter
C8250_RS31480	COG0569	domain protein
C8250_RS31485	COG0531	amino acid
C8250_RS31490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C8250_RS31525	COG2040	homocysteine
C8250_RS31535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C8250_RS31540	COG1024	Enoyl-CoA hydratase
C8250_RS31575	COG1960	acyl-CoA dehydrogenase activity
C8250_RS31585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8250_RS31605	COG3938	Belongs to the proline racemase family
C8250_RS31615	COG1802	Transcriptional regulator
C8250_RS31620	COG0006	proline dipeptidase activity
C8250_RS31630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS31645	COG4608	Belongs to the ABC transporter superfamily
C8250_RS31660	COG2267	carboxylic ester hydrolase activity
C8250_RS31725	COG1278	Cold shock
C8250_RS31730	COG0513	Belongs to the DEAD box helicase family
C8250_RS31740	COG2208	phosphoserine phosphatase activity
C8250_RS31765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C8250_RS31770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C8250_RS31775	COG1653	transport
C8250_RS31780	COG1175	transmembrane transport
C8250_RS31785	COG0395	ABC-type sugar transport system, permease component
C8250_RS31790	COG0656	L-ascorbic acid biosynthetic process
C8250_RS31820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C8250_RS31825	COG0546	phosphoglycolate phosphatase activity
C8250_RS31840	COG1940	carbohydrate kinase activity
C8250_RS31845	COG4213	ABC transporter substrate-binding protein
C8250_RS31855	COG4214	carbohydrate transport
C8250_RS31860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C8250_RS31865	COG0531	amino acid
C8250_RS31890	COG1024	Enoyl-CoA hydratase
C8250_RS31890	COG1250	3-hydroxyacyl-CoA dehydrogenase
C8250_RS31895	COG0183	Belongs to the thiolase family
C8250_RS31915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C8250_RS31925	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C8250_RS31930	COG3253	May function as heme-dependent peroxidase
C8250_RS31995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C8250_RS32000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C8250_RS32005	COG2197	response regulator
C8250_RS32010	COG4585	Histidine kinase
C8250_RS32015	COG0577	efflux transmembrane transporter activity
C8250_RS32040	COG2326	polyphosphate kinase activity
C8250_RS32085	COG4221	oxidoreductase activity
C8250_RS32140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C8250_RS32145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C8250_RS32145	COG1116	anion transmembrane transporter activity
C8250_RS32170	COG0529	Catalyzes the synthesis of activated sulfate
C8250_RS32175	COG0175	sulfate reduction
C8250_RS32210	COG1960	acyl-CoA dehydrogenase activity
C8250_RS32230	COG1162	GTPase activity
C8250_RS32245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C8250_RS32270	COG0028	Belongs to the TPP enzyme family
C8250_RS32320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C8250_RS32325	COG2252	PERMEase
C8250_RS32350	COG0395	ABC-type sugar transport system, permease component
C8250_RS32355	COG1175	transmembrane transport
C8250_RS32360	COG2182	Extracellular solute-binding protein
C8250_RS32365	COG2188	Transcriptional regulator
C8250_RS32405	COG3345	alpha-galactosidase
C8250_RS32415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C8250_RS32440	COG2197	response regulator
C8250_RS32445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C8250_RS32450	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS32465	COG3960	tartronate-semialdehyde synthase activity
C8250_RS32475	COG0753	catalase activity
C8250_RS32480	COG2084	Dehydrogenase
C8250_RS32485	COG3622	Belongs to the hyi family
C8250_RS32505	COG2351	hydroxyisourate hydrolase activity
C8250_RS32525	COG3548	integral membrane protein
C8250_RS32530	COG3104	oligopeptide transport
C8250_RS32560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C8250_RS32565	COG0746	molybdenum cofactor guanylyltransferase activity
C8250_RS32580	COG1414	Transcriptional regulator
C8250_RS32585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C8250_RS32590	COG4266	Belongs to the allantoicase family
C8250_RS32620	COG0395	ABC-type sugar transport system, permease component
C8250_RS32625	COG1175	transmembrane transport
C8250_RS32635	COG1940	carbohydrate kinase activity
C8250_RS32650	COG0800	Aldolase
C8250_RS32660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C8250_RS32665	COG1473	amidohydrolase
C8250_RS32665	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C8250_RS32675	COG3962	Belongs to the TPP enzyme family
C8250_RS32680	COG3718	enzyme involved in inositol metabolism
C8250_RS32690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8250_RS32700	COG0673	inositol 2-dehydrogenase activity
C8250_RS32705	COG2188	Transcriptional regulator
C8250_RS32730	COG1940	carbohydrate kinase activity
C8250_RS32770	COG1126	abc transporter atp-binding protein
C8250_RS32775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8250_RS32780	COG0765	amino acid transport
C8250_RS32785	COG0765	amino acid transport
C8250_RS32810	COG0405	Gamma-glutamyltransferase
C8250_RS32825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8250_RS32830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C8250_RS32835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C8250_RS32845	COG1953	Uracil, thiamine, allantoin
C8250_RS32850	COG0483	inositol monophosphate 1-phosphatase activity
C8250_RS32860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C8250_RS32880	COG1051	belongs to the nudix hydrolase family
C8250_RS32905	COG1929	Belongs to the glycerate kinase type-1 family
C8250_RS32915	COG0688	phosphatidylethanolamine metabolic process
C8250_RS32920	COG1960	acyl-CoA dehydrogenase activity
C8250_RS32930	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C8250_RS32930	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C8250_RS32945	COG1250	3-hydroxyacyl-CoA dehydrogenase
C8250_RS32955	COG0456	acetyltransferase
C8250_RS32970	COG2814	Major facilitator Superfamily
C8250_RS32980	COG1366	Belongs to the anti-sigma-factor antagonist family
C8250_RS32980	COG2172	sigma factor antagonist activity
C8250_RS32980	COG2208	phosphoserine phosphatase activity
C8250_RS32985	COG2226	methyltransferase
C8250_RS32990	COG2362	D-Aminopeptidase
C8250_RS32995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C8250_RS33005	COG1619	proteins homologs of microcin C7 resistance protein MccF
C8250_RS33010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C8250_RS33015	COG2205	protein histidine kinase activity
C8250_RS33020	COG0745	RESPONSE REGULATOR receiver
C8250_RS33040	COG0596	Alpha beta hydrolase
C8250_RS33060	COG2318	DinB family
C8250_RS33090	COG1793	dna ligase
C8250_RS33105	COG1404	Belongs to the peptidase S8 family
C8250_RS33120	COG1278	Cold shock
C8250_RS33125	COG0513	Belongs to the DEAD box helicase family
C8250_RS33135	COG4266	Belongs to the allantoicase family
C8250_RS33175	COG0671	phosphoesterase, PA-phosphatase related
C8250_RS33180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C8250_RS33225	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS33235	COG1309	transcriptional regulator
C8250_RS33245	COG2197	response regulator
C8250_RS33250	COG4585	Histidine kinase
C8250_RS33295	COG0656	L-ascorbic acid biosynthetic process
C8250_RS33330	COG0583	DNA-binding transcription factor activity
C8250_RS33350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C8250_RS33370	COG1605	Chorismate mutase
C8250_RS33370	COG0287	Prephenate dehydrogenase
C8250_RS33390	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS33415	COG0667	Aldo Keto reductase
C8250_RS33420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8250_RS33425	COG2313	pseudouridylate synthase activity
C8250_RS33430	COG0488	(ABC) transporter
C8250_RS33455	COG1309	transcriptional regulator
C8250_RS33475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C8250_RS33490	COG1834	amidinotransferase
C8250_RS33495	COG0488	(ABC) transporter
C8250_RS33535	COG1024	Enoyl-CoA hydratase
C8250_RS33550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C8250_RS33570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C8250_RS33585	COG1134	teichoic acid transport
C8250_RS33590	COG1562	ergosterol biosynthetic process
C8250_RS33600	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C8250_RS33610	COG1657	PFAM Prenyltransferase squalene oxidase
C8250_RS33625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C8250_RS33630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C8250_RS33645	COG2365	Tyrosine phosphatase family
C8250_RS33655	COG2755	lipolytic protein G-D-S-L family
C8250_RS33685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C8250_RS33730	COG3268	Saccharopine dehydrogenase
C8250_RS33740	COG0339	signal peptide processing
C8250_RS33755	COG2378	regulation of single-species biofilm formation
C8250_RS33770	COG0456	acetyltransferase
C8250_RS33845	COG3387	PFAM Glycoside hydrolase 15-related
C8250_RS33900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C8250_RS33920	COG1302	Protein conserved in bacteria
C8250_RS34010	COG0501	Belongs to the peptidase M48B family
C8250_RS34085	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C8250_RS34090	COG1063	alcohol dehydrogenase
C8250_RS34095	COG2072	flavoprotein involved in K transport
C8250_RS34125	COG2936	dipeptidyl-peptidase activity
C8250_RS34145	COG2936	dipeptidyl-peptidase activity
C8250_RS34155	COG0179	Fumarylacetoacetate (FAA) hydrolase
C8250_RS34170	COG0604	alcohol dehydrogenase
C8250_RS34180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C8250_RS34190	COG1802	Transcriptional regulator
C8250_RS34195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C8250_RS34205	COG1309	transcriptional regulator
C8250_RS34215	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8250_RS34220	COG1129	ABC transporter
C8250_RS34250	COG1309	transcriptional regulator
C8250_RS34260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8250_RS34270	COG1846	Transcriptional regulator
C8250_RS34335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS34340	COG0444	Belongs to the ABC transporter superfamily
C8250_RS34395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C8250_RS34425	COG0179	Fumarylacetoacetate (FAA) hydrolase
C8250_RS34440	COG1129	ABC transporter
C8250_RS34475	COG1609	Transcriptional regulator
C8250_RS34500	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C8250_RS34575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C8250_RS34580	COG0129	dihydroxy-acid dehydratase activity
C8250_RS34585	COG4134	Bacterial extracellular solute-binding protein
C8250_RS34665	COG4585	Histidine kinase
C8250_RS34670	COG2197	response regulator
C8250_RS34700	COG0640	Transcriptional regulator
C8250_RS34710	COG1937	Protein conserved in bacteria
C8250_RS34755	COG0492	ferredoxin-NADP+ reductase activity
C8250_RS34755	COG3118	belongs to the thioredoxin family
C8250_RS34760	COG2124	cytochrome p450
C8250_RS34785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8250_RS34795	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS34820	COG2409	Drug exporters of the RND superfamily
C8250_RS34870	COG0501	Belongs to the peptidase M48B family
C8250_RS34885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C8250_RS34905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C8250_RS34905	COG0674	pyruvate-flavodoxin oxidoreductase activity
C8250_RS34910	COG1013	pyruvate-flavodoxin oxidoreductase activity
C8250_RS34920	COG2372	response to copper ion
C8250_RS34935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8250_RS34945	COG0736	holo-[acyl-carrier-protein] synthase activity
C8250_RS34960	COG4106	trans-aconitate 2-methyltransferase activity
C8250_RS34965	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C8250_RS34975	COG0626	cystathionine gamma-synthase activity
C8250_RS35025	COG2315	Protein conserved in bacteria
C8250_RS35030	COG2315	Protein conserved in bacteria
C8250_RS35040	COG0667	Aldo Keto reductase
C8250_RS35045	COG1309	transcriptional regulator
C8250_RS35055	COG2272	Belongs to the type-B carboxylesterase lipase family
C8250_RS35075	COG0601	transmembrane transport
C8250_RS35080	COG0747	negative chemotaxis
C8250_RS35085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS35095	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS35100	COG2890	protein-(glutamine-N5) methyltransferase activity
C8250_RS35130	COG0069	glutamate synthase activity
C8250_RS35135	COG0028	Belongs to the TPP enzyme family
C8250_RS35140	COG1191	sigma factor activity
C8250_RS35190	COG2972	Histidine kinase
C8250_RS35190	COG2205	protein histidine kinase activity
C8250_RS35200	COG1136	(ABC) transporter
C8250_RS35205	COG1136	(ABC) transporter
C8250_RS35215	COG0745	RESPONSE REGULATOR receiver
C8250_RS35225	COG0745	RESPONSE REGULATOR receiver
C8250_RS35230	COG2205	protein histidine kinase activity
C8250_RS35240	COG0671	phosphoesterase, PA-phosphatase related
C8250_RS35260	COG0254	rRNA binding
C8250_RS35270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C8250_RS35275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C8250_RS35355	COG2272	Belongs to the type-B carboxylesterase lipase family
C8250_RS35360	COG3629	intracellular signal transduction
C8250_RS35360	COG3903	Transcriptional regulator
C8250_RS35365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C8250_RS35375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C8250_RS35380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8250_RS35395	COG3903	Transcriptional regulator
C8250_RS35395	COG2197	response regulator
C8250_RS35405	COG1063	alcohol dehydrogenase
C8250_RS35410	COG2957	Belongs to the agmatine deiminase family
C8250_RS35420	COG2409	Drug exporters of the RND superfamily
C8250_RS35440	COG2124	cytochrome p450
C8250_RS35465	COG3629	intracellular signal transduction
C8250_RS35465	COG3903	Transcriptional regulator
C8250_RS35485	COG1522	sequence-specific DNA binding
C8250_RS35490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS35510	COG2124	cytochrome p450
C8250_RS35550	COG2304	oxidoreductase activity
C8250_RS35555	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C8250_RS35595	COG0515	serine threonine protein kinase
C8250_RS35600	COG1595	DNA-templated transcription, initiation
C8250_RS35605	COG1090	epimerase
C8250_RS35610	COG0640	Transcriptional regulator
C8250_RS35620	COG2172	sigma factor antagonist activity
C8250_RS35620	COG2208	phosphoserine phosphatase activity
C8250_RS35620	COG1366	Belongs to the anti-sigma-factor antagonist family
C8250_RS35675	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C8250_RS35690	COG0667	Aldo Keto reductase
C8250_RS35695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C8250_RS35795	COG0248	Ppx GppA phosphatase
C8250_RS35810	COG0531	amino acid
C8250_RS35820	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C8250_RS35825	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C8250_RS35830	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C8250_RS35840	COG0531	amino acid
C8250_RS35850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C8250_RS35865	COG2323	membrane
C8250_RS35895	COG1609	Transcriptional regulator
C8250_RS35905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C8250_RS35925	COG0367	asparagine synthase
C8250_RS35960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C8250_RS35975	COG4310	Domain of unknown function (DUF2172)
C8250_RS35985	COG1215	transferase activity, transferring glycosyl groups
C8250_RS36000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C8250_RS36020	COG0657	acetylesterase activity
C8250_RS36040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8250_RS36050	COG0179	Fumarylacetoacetate (FAA) hydrolase
C8250_RS36055	COG3473	Maleate cis-trans isomerase
C8250_RS36065	COG0601	transmembrane transport
C8250_RS36070	COG0444	Belongs to the ABC transporter superfamily
C8250_RS36080	COG0747	negative chemotaxis
C8250_RS36115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C8250_RS36120	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS36125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C8250_RS36125	COG3321	synthase
C8250_RS36140	COG1131	(ABC) transporter
C8250_RS36150	COG2124	cytochrome p450
C8250_RS36160	COG1132	(ABC) transporter
C8250_RS36165	COG2274	protein secretion by the type I secretion system
C8250_RS36185	COG2197	response regulator
C8250_RS36230	COG0531	amino acid
C8250_RS36280	COG3511	phospholipase C
C8250_RS36335	COG3433	isochorismatase activity
C8250_RS36335	COG1535	isochorismatase
C8250_RS36340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C8250_RS36350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8250_RS36355	COG1120	ATPase activity
C8250_RS36395	COG1175	transmembrane transport
C8250_RS36400	COG0395	ABC-type sugar transport system, permease component
C8250_RS36445	COG0583	DNA-binding transcription factor activity
C8250_RS36450	COG1902	pentaerythritol trinitrate reductase activity
C8250_RS36450	COG0446	pyridine nucleotide-disulphide oxidoreductase
C8250_RS36490	COG1595	DNA-templated transcription, initiation
C8250_RS36515	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C8250_RS36525	COG1609	Transcriptional regulator
C8250_RS36530	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8250_RS36535	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8250_RS36540	COG1129	ABC transporter
C8250_RS36545	COG1879	ABC-type sugar transport system periplasmic component
C8250_RS36575	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C8250_RS36630	COG1960	acyl-CoA dehydrogenase activity
C8250_RS36635	COG1960	acyl-CoA dehydrogenase activity
C8250_RS36645	COG1309	transcriptional regulator
C8250_RS36650	COG0183	Belongs to the thiolase family
C8250_RS36655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C8250_RS36695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C8250_RS36710	COG2211	Major facilitator Superfamily
C8250_RS36710	COG2190	(PTS) system
C8250_RS36715	COG1024	Enoyl-CoA hydratase
C8250_RS36735	COG0028	Belongs to the TPP enzyme family
C8250_RS36740	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS36750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C8250_RS36755	COG4279	zinc finger
C8250_RS36780	COG2205	protein histidine kinase activity
C8250_RS36780	COG2972	Histidine kinase
C8250_RS36805	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS36810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C8250_RS36840	COG3321	synthase
C8250_RS36840	COG0604	alcohol dehydrogenase
C8250_RS36845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C8250_RS36895	COG2197	response regulator
C8250_RS36900	COG4585	Histidine kinase
C8250_RS36930	COG3629	intracellular signal transduction
C8250_RS36965	COG0662	Cupin 2, conserved barrel domain protein
C8250_RS36970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8250_RS36975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8250_RS36990	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS37005	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS37015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C8250_RS37020	COG2345	Transcriptional regulator
C8250_RS37025	COG2409	Drug exporters of the RND superfamily
C8250_RS37035	COG0475	glutathione-regulated potassium exporter activity
C8250_RS37050	COG2345	Transcriptional regulator
C8250_RS37080	COG2124	cytochrome p450
C8250_RS37085	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS37110	COG0367	asparagine synthase
C8250_RS37115	COG2867	negative regulation of translational initiation
C8250_RS37115	COG2226	methyltransferase
C8250_RS37120	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS37140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C8250_RS37160	COG2084	Dehydrogenase
C8250_RS37165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C8250_RS37170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8250_RS37175	COG1410	methionine synthase
C8250_RS37175	COG0646	methionine synthase
C8250_RS37185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C8250_RS37190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C8250_RS37200	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS37200	COG0604	alcohol dehydrogenase
C8250_RS37200	COG3321	synthase
C8250_RS37210	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS37225	COG0372	Belongs to the citrate synthase family
C8250_RS37230	COG0372	Belongs to the citrate synthase family
C8250_RS37260	COG0318	PFAM AMP-dependent synthetase and ligase
C8250_RS37270	COG2304	oxidoreductase activity
C8250_RS37285	COG0477	Major facilitator Superfamily
C8250_RS37320	COG1960	acyl-CoA dehydrogenase activity
C8250_RS37325	COG0183	Belongs to the thiolase family
C8250_RS37330	COG1024	Enoyl-CoA hydratase
C8250_RS37330	COG1250	3-hydroxyacyl-CoA dehydrogenase
C8250_RS37335	COG0789	Transcriptional regulator
C8250_RS37350	COG3239	Fatty acid desaturase
C8250_RS37360	COG2183	response to ionizing radiation
C8250_RS37370	COG2936	dipeptidyl-peptidase activity
C8250_RS37375	COG0514	ATP-dependent DNA helicase (RecQ)
C8250_RS37400	COG1077	Cell shape determining protein MreB Mrl
C8250_RS37405	COG1077	Cell shape determining protein MreB Mrl
C8250_RS37425	COG1077	Cell shape determining protein MreB Mrl
C8250_RS37455	COG2211	Major facilitator Superfamily
C8250_RS37460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C8250_RS37520	COG3250	beta-galactosidase activity
C8250_RS37525	COG3250	beta-galactosidase activity
C8250_RS37550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C8250_RS37575	COG1278	Cold shock
C8250_RS37580	COG0513	Belongs to the DEAD box helicase family
C8250_RS37635	COG0477	Major facilitator Superfamily
C8250_RS37695	COG0679	Auxin Efflux Carrier
C8250_RS37755	COG1940	carbohydrate kinase activity
C8250_RS37760	COG1129	ABC transporter
C8250_RS37770	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8250_RS37800	COG1131	(ABC) transporter
C8250_RS37805	COG0477	Major facilitator Superfamily
C8250_RS37835	COG0525	valine-tRNA ligase activity
C8250_RS37890	COG4977	sequence-specific DNA binding
C8250_RS37925	COG0519	Catalyzes the synthesis of GMP from XMP
C8250_RS37940	COG0363	glucosamine-6-phosphate deaminase activity
C8250_RS37955	COG0671	phosphoesterase, PA-phosphatase related
C8250_RS37960	COG2890	protein-(glutamine-N5) methyltransferase activity
C8250_RS37980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C8250_RS38010	COG1609	Transcriptional regulator
C8250_RS38020	COG1175	transmembrane transport
C8250_RS38025	COG0395	ABC-type sugar transport system, permease component
C8250_RS38030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C8250_RS38055	COG3619	membrane
C8250_RS38070	COG0667	Aldo Keto reductase
C8250_RS38085	COG0179	Fumarylacetoacetate (FAA) hydrolase
C8250_RS38090	COG4948	Mandelate Racemase Muconate Lactonizing
C8250_RS38100	COG3618	amidohydrolase
C8250_RS38120	COG1404	Belongs to the peptidase S8 family
C8250_RS38125	COG1674	ftsk spoiiie
C8250_RS38190	COG1595	DNA-templated transcription, initiation
C8250_RS38200	COG3321	synthase
C8250_RS38200	COG1028	Short-chain dehydrogenase reductase Sdr
C8250_RS38200	COG0604	alcohol dehydrogenase
C8250_RS38225	COG1473	amidohydrolase
C8250_RS38285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8250_RS38295	COG1674	ftsk spoiiie
C8250_RS38315	COG0464	growth
C8250_RS38340	COG0702	epimerase
C8250_RS38345	COG1278	Cold shock
C8250_RS38350	COG0702	epimerase
C8250_RS38370	COG1131	(ABC) transporter
C8250_RS38390	COG1940	carbohydrate kinase activity
C8250_RS38390	COG1846	Transcriptional regulator
C8250_RS38395	COG3345	alpha-galactosidase
C8250_RS38410	COG1316	TRANSCRIPTIONal
C8250_RS38425	COG2318	DinB family
C8250_RS38440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C8250_RS38465	COG2318	DinB family
C8250_RS38480	COG0494	nUDIX hydrolase
C8250_RS38490	COG1349	DNA-binding transcription factor activity
C8250_RS38495	COG3537	Alpha-1,2-mannosidase
C8250_RS38500	COG3152	Membrane
C8250_RS38525	COG0445	tRNA wobble uridine modification
C8250_RS38550	COG1131	(ABC) transporter
C8250_RS38555	COG4585	Histidine kinase
C8250_RS38560	COG2197	response regulator
C8250_RS38635	COG0515	serine threonine protein kinase
C8250_RS38635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8250_RS38645	COG2197	response regulator
C8250_RS38650	COG4585	Histidine kinase
C8250_RS38655	COG0577	efflux transmembrane transporter activity
C8250_RS38655	COG1136	(ABC) transporter
C8250_RS38665	COG0328	RNA-DNA hybrid ribonuclease activity
C8250_RS38675	COG0714	Associated with various cellular activities
C8250_RS38705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C8250_RS38715	COG1349	DNA-binding transcription factor activity
C8250_RS38740	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8250_RS38755	COG1869	D-ribose catabolic process
C8250_RS38760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8250_RS38765	COG1609	Transcriptional regulator
C8250_RS38850	COG2268	Band 7 protein
C8250_RS38885	COG3387	PFAM Glycoside hydrolase 15-related
C8250_RS38915	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C8250_RS38990	COG2205	protein histidine kinase activity
C8250_RS38995	COG0745	RESPONSE REGULATOR receiver
C8250_RS39005	COG1136	(ABC) transporter
C8250_RS39010	COG1136	(ABC) transporter
C8250_RS39020	COG0745	RESPONSE REGULATOR receiver
C8250_RS39090	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C8250_RS39110	COG5433	transposase activity
C8250_RS39115	COG0183	Belongs to the thiolase family
C8250_RS39120	COG0367	asparagine synthase
C8250_RS39125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C8250_RS39125	COG1796	DNA polymerase
C8250_RS39145	COG0702	epimerase
C8250_RS39150	COG3631	Ketosteroid isomerase-related protein
C8250_RS39165	COG3152	Membrane
C8250_RS39170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C8250_RS39205	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS39210	COG1309	transcriptional regulator
C8250_RS39365	COG1414	Transcriptional regulator
C8250_RS39390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C8250_RS39425	COG1309	transcriptional regulator
C8250_RS39440	COG0601	transmembrane transport
C8250_RS39445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8250_RS39460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C8250_RS39475	COG5006	permease, DMT superfamily
C8250_RS39500	COG4977	sequence-specific DNA binding
C8250_RS39510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C8250_RS39540	COG3851	Histidine kinase
C8250_RS39545	COG2197	response regulator
C8250_RS39575	COG3973	AAA domain
C8250_RS39580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C8250_RS39585	COG2409	Drug exporters of the RND superfamily
C8250_RS39590	COG4585	Histidine kinase
C8250_RS39605	COG2124	cytochrome p450
C8250_RS39610	COG2267	carboxylic ester hydrolase activity
C8250_RS39645	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C8250_RS39650	COG0714	Associated with various cellular activities
C8250_RS39715	COG0596	Alpha beta hydrolase
C8250_RS39720	COG2208	phosphoserine phosphatase activity
C8250_RS39720	COG2770	Histidine kinase
C8250_RS39785	COG0596	Alpha beta hydrolase
C8250_RS39795	COG0456	acetyltransferase
C8250_RS39795	COG1846	Transcriptional regulator
C8250_RS39800	COG2072	flavoprotein involved in K transport
C8250_RS39810	COG3340	Belongs to the peptidase S51 family
C8250_RS39860	COG1733	regulation of RNA biosynthetic process
C8250_RS39890	COG4977	sequence-specific DNA binding
C8250_RS39930	COG1278	Cold shock
C8250_RS39975	COG4934	collagen metabolic process
C8250_RS39980	COG0515	serine threonine protein kinase
C8250_RS39980	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8250_RS39985	COG0395	ABC-type sugar transport system, permease component
C8250_RS39990	COG1175	transmembrane transport
C8250_RS39995	COG1653	transport
C8250_RS40000	COG0366	Alpha amylase catalytic
C8250_RS40005	COG1653	transport
C8250_RS40010	COG1695	Transcriptional regulator
C8250_RS40015	COG1136	(ABC) transporter
C8250_RS40015	COG0577	efflux transmembrane transporter activity
C8250_RS40040	COG3250	beta-galactosidase activity
C8250_RS40075	COG1278	Cold shock
C8250_RS40105	COG0596	Alpha beta hydrolase
C8250_RS40145	COG0583	DNA-binding transcription factor activity
C8250_RS40185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C8250_RS40205	COG3953	SLT domain
C8250_RS40205	COG5412	phage tail tape measure protein
C8250_RS40255	COG4941	Belongs to the sigma-70 factor family
C8250_RS40260	COG3795	YCII-related domain
C8250_RS40275	COG1131	(ABC) transporter
C8250_RS40280	COG4585	Histidine kinase
C8250_RS40285	COG2197	response regulator
C8250_RS40310	COG1846	Transcriptional regulator
C8250_RS40315	COG2267	carboxylic ester hydrolase activity
C8250_RS40340	COG1595	DNA-templated transcription, initiation
C8250_RS40345	COG0778	Nitroreductase
C8250_RS40350	COG1733	regulation of RNA biosynthetic process
C8250_RS40355	COG1366	Belongs to the anti-sigma-factor antagonist family
C8250_RS40370	COG2249	NAD(P)H dehydrogenase (quinone) activity
C8250_RS40405	COG3655	Transcriptional regulator
C8250_RS40455	COG2226	methyltransferase
C8250_RS40475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C8250_RS40495	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C8250_RS40520	COG4552	Acetyltransferase involved in intracellular survival and related
C8250_RS40545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C8250_RS40555	COG1882	Formate acetyltransferase
C8250_RS40560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C8250_RS40575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C8250_RS40575	COG0574	Belongs to the PEP-utilizing enzyme family
C8250_RS40585	COG4716	Myosin-crossreactive antigen
C8250_RS40595	COG0531	amino acid
C8250_RS40605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C8250_RS40610	COG0549	Belongs to the carbamate kinase family
C8250_RS40635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C8250_RS40685	COG0281	malic enzyme
C8250_RS40710	COG0659	secondary active sulfate transmembrane transporter activity
C8250_RS40720	COG0589	response to stress
C8250_RS40745	COG0589	response to stress
C8250_RS40755	COG4716	Myosin-crossreactive antigen
C8250_RS40765	COG0516	GMP reductase activity
C8250_RS40765	COG0517	IMP dehydrogenase activity
C8250_RS40790	COG1017	nitric oxide dioxygenase activity
C8250_RS40790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8250_RS40800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8250_RS40805	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8250_RS40810	COG1120	ATPase activity
C8250_RS40820	COG1132	(ABC) transporter
C8250_RS40825	COG1132	(ABC) transporter
C8250_RS40840	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C8250_RS40855	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C8250_RS40870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C8250_RS40875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C8250_RS40880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C8250_RS40885	COG3433	isochorismatase activity
C8250_RS40885	COG1535	isochorismatase
C8250_RS40905	COG1733	regulation of RNA biosynthetic process
C8250_RS40910	COG0702	epimerase
C8250_RS40975	COG4584	PFAM Integrase catalytic
C8250_RS41020	COG4213	ABC transporter substrate-binding protein
C8250_RS41035	COG2045	Belongs to the ComB family
C8250_RS41055	COG2226	methyltransferase
C8250_RS41130	COG0681	Belongs to the peptidase S26 family
C8250_RS41135	COG1846	Transcriptional regulator
C8250_RS41150	COG0406	alpha-ribazole phosphatase activity
C8250_RS41165	COG0745	RESPONSE REGULATOR receiver
C8250_RS41170	COG0642	Histidine kinase
C8250_RS41210	COG0402	S-adenosylhomocysteine deaminase activity
C8250_RS41255	COG5002	protein histidine kinase activity
C8250_RS41260	COG0745	RESPONSE REGULATOR receiver
C8250_RS41270	COG0577	efflux transmembrane transporter activity
C8250_RS41270	COG1136	(ABC) transporter
C8250_RS41275	COG0577	efflux transmembrane transporter activity
C8250_RS41290	COG1280	lysine exporter protein (LysE YggA)
C8250_RS41300	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C8250_RS41305	COG0587	DNA-directed DNA polymerase activity
C8250_RS41360	COG0693	protein deglycase activity
C8250_RS41370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C8250_RS41395	COG1191	sigma factor activity
C8250_RS41405	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C8250_RS41420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C8250_RS41475	COG0346	lactoylglutathione lyase activity
C8250_RS41555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C8250_RS41560	COG1653	transport
C8250_RS41565	COG4209	transmembrane transport
C8250_RS41570	COG0395	ABC-type sugar transport system, permease component
C8250_RS41600	COG1846	Transcriptional regulator
C8250_RS41665	COG0483	inositol monophosphate 1-phosphatase activity
C8250_RS41685	COG2226	methyltransferase
C8250_RS41690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C8250_RS41705	COG3903	Transcriptional regulator
C8250_RS41705	COG3629	intracellular signal transduction
C8250_RS41745	COG2066	Belongs to the glutaminase family
C8250_RS41755	COG0583	DNA-binding transcription factor activity
C8250_RS41760	COG4221	oxidoreductase activity
C8250_RS41780	COG3979	chitinase
C8250_RS41795	COG1733	regulation of RNA biosynthetic process
C8250_RS41845	COG2226	methyltransferase
C8250_RS41855	COG1454	alcohol dehydrogenase
C8250_RS41855	COG1012	belongs to the aldehyde dehydrogenase family
C8250_RS41885	COG1882	Formate acetyltransferase
C8250_RS41890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C8250_RS41895	COG0589	response to stress
C8250_RS41910	COG2197	response regulator
C8250_RS41925	COG1595	DNA-templated transcription, initiation
C8250_RS42060	COG1733	regulation of RNA biosynthetic process
C8250_RS42145	COG0395	ABC-type sugar transport system, permease component
C8250_RS42150	COG4209	transmembrane transport
C8250_RS42155	COG1609	Transcriptional regulator
C8250_RS42225	COG1191	sigma factor activity
C8250_RS42240	COG3422	double-strand break repair
C8250_RS42250	COG3385	transposase activity
C8250_RS42295	COG3547	Transposase (IS116 IS110 IS902 family)
C8250_RS42305	COG1523	belongs to the glycosyl hydrolase 13 family
C8250_RS42315	COG2182	Extracellular solute-binding protein
C8250_RS42320	COG1175	transmembrane transport
C8250_RS42325	COG3833	ABC-type maltose transport systems, permease component
C8250_RS42330	COG0366	Alpha amylase catalytic
C8250_RS42390	COG1595	DNA-templated transcription, initiation
C8250_RS42510	COG2801	Transposase and inactivated derivatives
C8250_RS42640	COG3293	Transposase
C8250_RS42710	COG3385	transposase activity
C8250_RS42800	COG0702	epimerase
C8250_RS42840	COG0667	Aldo Keto reductase