locus-tag class description GQF42_RS00135 ENOG41082SX arsR family transcriptional regulator GQF42_RS00145 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GQF42_RS00155 ENOG4107TB5 TRANSCRIPTIONal GQF42_RS00170 ENOG4107TB5 TRANSCRIPTIONal GQF42_RS00180 ENOG4105HSS phospholipase C GQF42_RS00245 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GQF42_RS00250 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GQF42_RS00255 ENOG4108KGH TRANSCRIPTIONal GQF42_RS00360 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GQF42_RS00365 ENOG4105CXN decarboxylase GQF42_RS00430 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GQF42_RS00440 ENOG4105FDF Could be involved in DNA repair (By similarity) GQF42_RS00530 ENOG4105D5G Transposase GQF42_RS00620 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GQF42_RS00635 ENOG41060M0 Crispr-associated protein, cse4 family GQF42_RS00665 ENOG4105EKQ RNA-directed DNA polymerase GQF42_RS00755 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS00760 ENOG4105BZU Histidine kinase GQF42_RS00775 ENOG4105DA5 (ABC) transporter GQF42_RS00840 ENOG4105D0M Protease HtpX homolog GQF42_RS00935 ENOG4105E09 nadh pyrophosphatase GQF42_RS01020 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GQF42_RS01040 ENOG4107SCK Monooxygenase GQF42_RS01045 ENOG41085W3 Transposase GQF42_RS01060 ENOG4105C9Q fumarate hydratase class II GQF42_RS01080 ENOG4105CPC Aldo Keto reductase GQF42_RS01095 ENOG41085W3 Transposase GQF42_RS01115 ENOG4105EGE secreted protein GQF42_RS01140 ENOG4105CHJ isochorismatase hydrolase GQF42_RS01170 ENOG4108YIQ Alpha beta hydrolase GQF42_RS01220 ENOG4105CHR reductase GQF42_RS01235 ENOG41085W3 Transposase GQF42_RS01290 ENOG4105DMF Dehydrogenase GQF42_RS01295 ENOG4105FP9 thiamine pyrophosphate GQF42_RS01305 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS01330 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GQF42_RS01335 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GQF42_RS01395 ENOG4105C7W Xanthine dehydrogenase GQF42_RS01485 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GQF42_RS01670 ENOG41082AN stage II sporulation protein GQF42_RS01820 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GQF42_RS01915 ENOG4105CJ1 ABC, transporter GQF42_RS01955 ENOG4107S5I aldo keto reductase GQF42_RS01980 ENOG4105ETX regulatoR GQF42_RS01985 ENOG4105EB3 Histidine kinase GQF42_RS02060 ENOG4105CHR reductase GQF42_RS02115 ENOG4108KQ5 Integrase catalytic subunit GQF42_RS02170 ENOG4107SGM protein serine threonine phosphatase GQF42_RS02200 ENOG4105MD1 YeeE YedE family protein GQF42_RS02215 ENOG4105VEQ Cold shock protein GQF42_RS02235 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GQF42_RS02250 ENOG4105VDT -acetyltransferase GQF42_RS02285 ENOG4107QRI Phosphoketolase GQF42_RS02320 ENOG4105CIR epoxide hydrolase GQF42_RS02350 ENOG4108TCJ secreted hydrolase GQF42_RS02390 ENOG4105FBW Monooxygenase GQF42_RS02395 ENOG4105DND Transcriptional regulator GQF42_RS02410 ENOG4105DEN Luciferase family GQF42_RS02420 ENOG4105CPU Monooxygenase GQF42_RS02435 ENOG4105CDA abc transporter atp-binding protein GQF42_RS02470 ENOG4107UWC ABC, transporter GQF42_RS02475 ENOG4105E2Y ABC, transporter GQF42_RS02480 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GQF42_RS02490 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GQF42_RS02510 ENOG4105CPU Monooxygenase GQF42_RS02515 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GQF42_RS02535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GQF42_RS02545 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GQF42_RS02610 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS02650 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS02655 ENOG4105CNT hydrolase family 2 GQF42_RS02670 ENOG4105I1K ABC transporter GQF42_RS02720 ENOG4107TB5 TRANSCRIPTIONal GQF42_RS02725 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GQF42_RS02750 ENOG4105NAE bifunctional deaminase-reductase domain protein GQF42_RS02775 ENOG4107SCK Monooxygenase GQF42_RS02800 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GQF42_RS02810 ENOG4105DUM transcriptional regulator, lysR family GQF42_RS02830 ENOG4105KVH Transcriptional regulator GQF42_RS02875 ENOG4105F5W AtP-binding protein GQF42_RS02900 ENOG4105KXC Collagenase GQF42_RS02975 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GQF42_RS03095 ENOG4108WUZ (ABC) transporter GQF42_RS03140 ENOG4108IG5 Transcriptional regulator GQF42_RS03145 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase GQF42_RS03175 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GQF42_RS03180 ENOG4105FUA antagonist GQF42_RS03185 ENOG4107MMM Anti-sigma-factor antagonist GQF42_RS03195 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GQF42_RS03215 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GQF42_RS03245 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) GQF42_RS03265 ENOG4105D74 hydrolase GQF42_RS03290 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GQF42_RS03295 ENOG4108Z40 Transcriptional regulator GQF42_RS03305 ENOG4105K8R UPF0145 protein GQF42_RS03330 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GQF42_RS03345 ENOG4105BZ1 (ABC) transporter GQF42_RS03350 ENOG4108Z4K mutator MutT protein GQF42_RS03385 ENOG4105CF7 AraC family transcriptional regulator GQF42_RS03390 ENOG4105CPC Aldo Keto reductase GQF42_RS03395 ENOG4105CHR reductase GQF42_RS03420 ENOG4105CIR epoxide hydrolase GQF42_RS03445 ENOG4105CIS alcohol dehydrogenase GQF42_RS03455 ENOG4105K56 Transcriptional regulator GQF42_RS03475 ENOG4105HSS phospholipase C GQF42_RS03515 ENOG4105C7B Threonine dehydratase GQF42_RS03530 ENOG4105WQT MbtH domain protein GQF42_RS03540 ENOG4105EC3 peptidase S51, dipeptidase E GQF42_RS03550 ENOG4108S01 response regulator GQF42_RS03575 ENOG4106A3M Cytochrome p-450 GQF42_RS03600 ENOG4107RSM transcriptional regulator GQF42_RS03665 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GQF42_RS03685 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GQF42_RS03690 ENOG4108K8U Glycerol operon regulatory protein GQF42_RS03730 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GQF42_RS03735 ENOG4105CPC Aldo Keto reductase GQF42_RS03760 ENOG4105DFW ABC transporter GQF42_RS03805 ENOG4105DPX Hydrogenase, large subunit GQF42_RS03840 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GQF42_RS03860 ENOG4105CQS hydrogenase expression formation protein HypD GQF42_RS03875 ENOG41087PP glycosyltransferase MGT family GQF42_RS03890 ENOG4105BZ4 penicillin-binding protein GQF42_RS03920 ENOG4105C26 Dehydrogenase GQF42_RS03950 ENOG4105CWX Alpha-1,2-mannosidase GQF42_RS03975 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GQF42_RS03980 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GQF42_RS04000 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GQF42_RS04005 ENOG4105KT7 mgtC SapB transporter GQF42_RS04045 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid GQF42_RS04060 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS04065 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GQF42_RS04090 ENOG4107RB3 L-asparaginase GQF42_RS04100 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GQF42_RS04110 ENOG4105KVH Transcriptional regulator GQF42_RS04140 ENOG4105EQK -acetyltransferase GQF42_RS04180 ENOG4105CSR polyphosphate kinase 2 GQF42_RS04210 ENOG4105DIA mandelate racemase muconate lactonizing GQF42_RS04230 ENOG4105KVH Transcriptional regulator GQF42_RS04235 ENOG4105CNI cell division protein FtsW GQF42_RS04245 ENOG4105EUZ Beta-lactamase domain protein GQF42_RS04260 ENOG4105D3W isochorismatase GQF42_RS04265 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GQF42_RS04280 ENOG4105CD5 CoA-binding domain protein GQF42_RS04290 ENOG4107QIZ NADH dehydrogenase GQF42_RS04300 ENOG4105DVW rieske (2Fe-2S) GQF42_RS04310 ENOG4105F38 ABC transporter, permease GQF42_RS04315 ENOG4105D38 putrescine abc transporter GQF42_RS04320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GQF42_RS04330 ENOG4105C26 Dehydrogenase GQF42_RS04355 ENOG4105C7W Xanthine dehydrogenase GQF42_RS04360 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GQF42_RS04365 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GQF42_RS04385 ENOG4105FP9 thiamine pyrophosphate GQF42_RS04470 ENOG4105CBP Major Facilitator GQF42_RS04480 ENOG4106NZI LysR family Transcriptional regulator GQF42_RS04505 ENOG4105CHR reductase GQF42_RS04520 ENOG4108NNZ chitinase GQF42_RS04535 ENOG4105CIG ABC transporter GQF42_RS04560 ENOG41080E2 ribosomal-protein-alanine acetyltransferase GQF42_RS04570 ENOG4105E39 Enoyl-CoA hydratase GQF42_RS04595 ENOG4108ME1 Peptidase M55 D-aminopeptidase GQF42_RS04625 ENOG4107R7A Allophanate hydrolase subunit 2 GQF42_RS04635 ENOG4105E7W lamb ycsf family protein GQF42_RS04650 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GQF42_RS04675 ENOG4108KC1 acyl-Coa dehydrogenase GQF42_RS04680 ENOG4107TPS domain protein GQF42_RS04690 ENOG4108VCT Sulfite exporter TauE/SafE GQF42_RS04695 ENOG4105VPX protein, conserved in bacteria GQF42_RS04700 ENOG4105WZW rhodanese family GQF42_RS04705 ENOG4105CAY ferredoxin--nadp reductase GQF42_RS04725 ENOG4108ZJ4 polysaccharide deacetylase GQF42_RS04730 ENOG4105DQR SNARE associated Golgi GQF42_RS04750 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GQF42_RS04765 ENOG4105ECQ AraC Family Transcriptional Regulator GQF42_RS04770 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS04775 ENOG4105BZU Histidine kinase GQF42_RS04805 ENOG4107RSM transcriptional regulator GQF42_RS04810 ENOG4105EYF MMPL domain protein GQF42_RS04830 ENOG4105EYF MMPL domain protein GQF42_RS04835 ENOG41067SE Tetr family transcriptional regulator GQF42_RS04935 ENOG4108VQR secreted hydrolase GQF42_RS04940 ENOG4105CMR udp-glucose 4-epimerase GQF42_RS04945 ENOG4105BZU Histidine kinase GQF42_RS04950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GQF42_RS04980 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS04995 ENOG4105ECP epimerase GQF42_RS05020 ENOG4107TB5 TRANSCRIPTIONal GQF42_RS05025 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GQF42_RS05030 ENOG41082SX arsR family transcriptional regulator GQF42_RS05075 ENOG4108PJD permease GQF42_RS05115 ENOG4105DUM transcriptional regulator, lysR family GQF42_RS05160 ENOG41060NJ transcriptional regulator GQF42_RS05210 ENOG4108IAJ Nad-dependent epimerase dehydratase GQF42_RS05220 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GQF42_RS05250 ENOG4105CPC Aldo Keto reductase GQF42_RS05270 ENOG4105DQR SNARE associated Golgi GQF42_RS05275 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GQF42_RS05280 ENOG4105C0R drug resistance transporter emrb qaca subfamily GQF42_RS05335 ENOG4105KXC Collagenase GQF42_RS05345 ENOG4108KXM LysR family Transcriptional regulator GQF42_RS05355 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) GQF42_RS05455 ENOG4107RTD sua5 ycio yrdc ywlc family protein GQF42_RS05475 ENOG410836F Transposase GQF42_RS05480 ENOG4107SVN transposase GQF42_RS05530 ENOG4105F0K SARP family transcriptional regulator GQF42_RS05545 ENOG4107S5I aldo keto reductase GQF42_RS05560 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) GQF42_RS05570 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein GQF42_RS05600 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GQF42_RS05645 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GQF42_RS05655 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GQF42_RS05660 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GQF42_RS05665 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GQF42_RS05750 ENOG4105C5X domain protein GQF42_RS05795 ENOG4105K4I Scp-like extracellular GQF42_RS05820 ENOG4107QPV Serine Threonine protein kinase GQF42_RS05835 ENOG4107SET aldo keto reductase GQF42_RS05850 ENOG4105C0R drug resistance transporter emrb qaca subfamily GQF42_RS05875 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GQF42_RS05885 ENOG4105ESN nucleotide-binding protein GQF42_RS05895 ENOG4108PA7 Methyltransferase GQF42_RS05910 ENOG4105CIR epoxide hydrolase GQF42_RS05915 ENOG4105WBV Transcriptional regulator GQF42_RS05945 ENOG4105IDI abc transporter atp-binding protein GQF42_RS05970 ENOG4105CPC Aldo Keto reductase GQF42_RS05975 ENOG4108M0I Transcriptional regulator GQF42_RS05990 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GQF42_RS05995 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GQF42_RS06010 ENOG4107S5I aldo keto reductase GQF42_RS06015 ENOG4105C26 Dehydrogenase GQF42_RS06035 ENOG4105CVP deoxyribo-dipyrimidine photolyase GQF42_RS06060 ENOG4105CUB amino acid GQF42_RS06065 ENOG4105DKQ ROK family GQF42_RS06090 ENOG4108Z6Z Transcriptional regulator GQF42_RS06095 ENOG4105F27 Major Facilitator GQF42_RS06130 ENOG4105CAQ asparagine synthetase GQF42_RS06135 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GQF42_RS06145 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GQF42_RS06155 ENOG4105KF0 sporulation and cell division protein, SsgA GQF42_RS06210 ENOG4105E39 Enoyl-CoA hydratase GQF42_RS06240 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS06275 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GQF42_RS06280 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GQF42_RS06300 ENOG4105E2A Dehydrogenase GQF42_RS06310 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GQF42_RS06350 ENOG4105E2A Dehydrogenase GQF42_RS06375 ENOG4105X7H acyl-CoA dehydrogenase GQF42_RS06385 ENOG4107YVI ribose 5-phosphate isomerase GQF42_RS06410 ENOG4105CMT Dihydroxyacetone kinase GQF42_RS06415 ENOG4108UTZ Dihydroxyacetone kinase GQF42_RS06420 ENOG4105VDH Dihydroxyacetone kinase GQF42_RS06430 ENOG4106R7G Glycoside hydrolase family 5 GQF42_RS06445 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GQF42_RS06470 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GQF42_RS06480 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GQF42_RS06525 ENOG4105I82 acetyl xylan esterase GQF42_RS06530 ENOG41073TP transcriptional regulator GQF42_RS06535 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) GQF42_RS06570 ENOG41090CE integral membrane protein GQF42_RS06575 ENOG4105CSV Glutaminase GQF42_RS06580 ENOG4108IJ0 Aspartate ammonia-lyase GQF42_RS06595 ENOG41073TP transcriptional regulator GQF42_RS06600 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GQF42_RS06610 ENOG4105KJJ Uncharacterized ACR, COG1993 GQF42_RS06615 ENOG41083YR Protein CrcB homolog GQF42_RS06635 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS06640 ENOG4105BZU Histidine kinase GQF42_RS06645 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GQF42_RS06665 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) GQF42_RS06690 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GQF42_RS06705 ENOG4108RPX mosc domain containing protein GQF42_RS06725 ENOG4105D9G High-affinity GQF42_RS06800 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GQF42_RS06805 ENOG4107RRZ synthase GQF42_RS06830 ENOG4106F1P AAA ATPase, central domain protein GQF42_RS06840 ENOG4105MVE transcriptional regulator GQF42_RS06890 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF GQF42_RS06895 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GQF42_RS06900 ENOG4105E2Y ABC, transporter GQF42_RS06910 ENOG4105XDF Protein of unknown function (DUF1272) GQF42_RS06920 ENOG4105DKQ ROK family GQF42_RS06925 ENOG4105CF1 Alkylated DNA repair protein GQF42_RS06930 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) GQF42_RS06935 ENOG4105D2N Aldolase GQF42_RS06940 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GQF42_RS06945 ENOG4105E98 transcriptional regulator DeoR family GQF42_RS06980 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS06985 ENOG4105BZU Histidine kinase GQF42_RS07000 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GQF42_RS07005 ENOG4107PP3 Acetylornithine deacetylase GQF42_RS07015 ENOG4105I1F Resistance protein GQF42_RS07030 ENOG4105EX0 alpha-galactosidase GQF42_RS07040 ENOG41060NJ transcriptional regulator GQF42_RS07055 ENOG4105C10 Electron transfer flavoprotein GQF42_RS07075 ENOG4105PSQ Acyl-transferase GQF42_RS07100 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GQF42_RS07160 ENOG4105C2W permease GQF42_RS07170 ENOG4105YVS arsR family transcriptional regulator GQF42_RS07175 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GQF42_RS07190 ENOG4105CSU acyl-Coa dehydrogenase GQF42_RS07210 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GQF42_RS07215 ENOG4105RD7 BadF BadG BcrA BcrD GQF42_RS07225 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GQF42_RS07240 ENOG4107VXZ Hydrolase GQF42_RS07335 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GQF42_RS07375 ENOG4107SVN transposase GQF42_RS07405 ENOG4105C1J atp-dependent rna helicase GQF42_RS07410 ENOG4105VEQ Cold shock protein GQF42_RS07415 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GQF42_RS07510 ENOG4105C1G acyl-Coa dehydrogenase GQF42_RS07540 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GQF42_RS07545 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GQF42_RS07550 ENOG4106A3M Cytochrome p-450 GQF42_RS07565 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GQF42_RS07580 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GQF42_RS07585 ENOG4105E2B Taurine dioxygenase GQF42_RS07590 ENOG4108VQT Alpha beta hydrolase fold protein GQF42_RS07600 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GQF42_RS07625 ENOG4105CN5 Metallo-Beta-Lactamase GQF42_RS07640 ENOG4107ZED Uncharacterised protein family UPF0047 GQF42_RS07645 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GQF42_RS07650 ENOG4105E2Y ABC, transporter GQF42_RS07660 ENOG4105F95 Monooxygenase GQF42_RS07670 ENOG4105BZ1 (ABC) transporter GQF42_RS07695 ENOG4105BZ1 (ABC) transporter GQF42_RS07720 ENOG4105C29 acyl-CoA thioesterase GQF42_RS07730 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GQF42_RS07760 ENOG4105DQE DNA ligase GQF42_RS07780 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GQF42_RS07785 ENOG4105EMU Dehydrogenase GQF42_RS07800 ENOG4105GWZ Roadblock lc7 family protein GQF42_RS07825 ENOG4105BZU Histidine kinase GQF42_RS07875 ENOG4105EKQ RNA-directed DNA polymerase GQF42_RS07900 ENOG4105E2R ROK family GQF42_RS07910 ENOG4107SCA Formamidase (EC 3.5.1.49) GQF42_RS07920 ENOG4107RR1 TRANSCRIPTIONal GQF42_RS07925 ENOG4105C26 Dehydrogenase GQF42_RS07965 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GQF42_RS07970 ENOG4106BQ7 Glycosyl Transferase GQF42_RS07980 ENOG4105XDV GQF42_RS08000 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS08025 ENOG4105CHU acetyl-coa acetyltransferase GQF42_RS08055 ENOG4107QN1 sodium solute GQF42_RS08060 ENOG4105CSU acyl-Coa dehydrogenase GQF42_RS08065 ENOG4105CHR reductase GQF42_RS08080 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS08090 ENOG4105C26 Dehydrogenase GQF42_RS08120 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS08135 ENOG4105CHR reductase GQF42_RS08180 ENOG4105CHJ isochorismatase hydrolase GQF42_RS08185 ENOG4108VGI doxx family GQF42_RS08190 ENOG4105XPP Protein of unknown function (DUF1275) GQF42_RS08195 ENOG4107SFI Major Facilitator superfamily GQF42_RS08200 ENOG4105C7K acetolactate synthase GQF42_RS08235 ENOG4105KF0 sporulation and cell division protein, SsgA GQF42_RS08245 ENOG4105C4M (Ubiquinol oxidase) subunit I GQF42_RS08255 ENOG4108JJ9 ABC, transporter GQF42_RS08260 ENOG4108JJ8 (ABC) transporter GQF42_RS08265 ENOG4108UZX fmn reductase GQF42_RS08270 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GQF42_RS08300 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GQF42_RS08305 ENOG4105I1K ABC transporter GQF42_RS08310 ENOG4108YIQ Alpha beta hydrolase GQF42_RS08315 ENOG4108YIQ Alpha beta hydrolase GQF42_RS08375 ENOG410880H cysteine synthase GQF42_RS08395 ENOG4105DQR SNARE associated Golgi GQF42_RS08430 ENOG4105D2B acyl-CoA dehydrogenase GQF42_RS08435 ENOG4105D2B acyl-CoA dehydrogenase GQF42_RS08440 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GQF42_RS08450 ENOG4108JU3 Alkyl hydroperoxide reductase GQF42_RS08455 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GQF42_RS08480 ENOG41065KQ synthase GQF42_RS08485 ENOG4106A3M Cytochrome p-450 GQF42_RS08495 ENOG4105C1G acyl-Coa dehydrogenase GQF42_RS08505 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GQF42_RS08515 ENOG4105F1K Glutamine amidotransferase GQF42_RS08520 ENOG4105CTQ phosphohexokinase GQF42_RS08540 ENOG4105CIK Amidinotransferase GQF42_RS08545 ENOG4105C8Y Acetylornithine aminotransferase GQF42_RS08560 ENOG4105F6E Acyl-transferase GQF42_RS08590 ENOG4105CQM Urea amidohydrolase subunit alpha GQF42_RS08595 ENOG4105KI2 Urea amidohydrolase subunit beta GQF42_RS08600 ENOG4108YZ9 Urea amidohydrolase subunit gamma GQF42_RS08645 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GQF42_RS08650 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GQF42_RS08655 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GQF42_RS08660 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GQF42_RS08665 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GQF42_RS08680 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GQF42_RS08685 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GQF42_RS08690 ENOG4105FBW Monooxygenase GQF42_RS08695 ENOG4108R6G acetyltransferase GQF42_RS08750 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS08755 ENOG4105C0W non-ribosomal peptide synthetase GQF42_RS08780 ENOG4106YKD Cytochrome p-450 GQF42_RS08795 ENOG4105DTD Dehydrogenase GQF42_RS08805 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS08815 ENOG4107R34 abc transporter permease protein GQF42_RS08820 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GQF42_RS08830 ENOG4108JA1 polyketide synthase GQF42_RS08850 ENOG4105C83 adenylosuccinate lyase GQF42_RS08855 ENOG4108VCA G U mismatch-specific DNA glycosylase GQF42_RS08870 ENOG4105DKQ ROK family GQF42_RS08875 ENOG4105FDP GntR family transcriptional regulator GQF42_RS08880 ENOG4108KPJ rna polymerase sigma factor GQF42_RS08890 ENOG4106HB6 Alpha beta hydrolase GQF42_RS08930 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase GQF42_RS08965 ENOG4105E98 transcriptional regulator DeoR family GQF42_RS09000 ENOG4105EYH Exonuclease GQF42_RS09010 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GQF42_RS09025 ENOG4105K4P CoA-binding domain protein GQF42_RS09030 ENOG4107QTZ amino acid GQF42_RS09040 ENOG41082SX arsR family transcriptional regulator GQF42_RS09065 ENOG4108UW5 maltose o-acetyltransferase GQF42_RS09070 ENOG4108Z0R Transferase GQF42_RS09120 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GQF42_RS09140 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GQF42_RS09160 ENOG4105CHU acetyl-coa acetyltransferase GQF42_RS09165 ENOG4107YPT transcriptional regulator GQF42_RS09170 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GQF42_RS09190 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GQF42_RS09195 ENOG4105EP9 oxidoreductase GQF42_RS09230 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GQF42_RS09240 ENOG4105CHR reductase GQF42_RS09260 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GQF42_RS09275 ENOG4105C5Q Transcriptional regulator GQF42_RS09280 ENOG4108Q5Y Membrane GQF42_RS09285 ENOG4105CSW GntR family transcriptional regulator GQF42_RS09315 ENOG4105NTW Transcriptional regulator GQF42_RS09340 ENOG4107TIF Phenazine biosynthesis protein, PhzF family GQF42_RS09395 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GQF42_RS09415 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GQF42_RS09425 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GQF42_RS09495 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GQF42_RS09505 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GQF42_RS09530 ENOG4105BZU Histidine kinase GQF42_RS09535 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GQF42_RS09540 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GQF42_RS09555 ENOG4105GWZ Roadblock lc7 family protein GQF42_RS09595 ENOG41090WU lipolytic protein G-D-S-L family GQF42_RS09600 ENOG4108MJN Glycosyl Transferase GQF42_RS09615 ENOG4105JXB ankyrin repeat-containing protein GQF42_RS09640 ENOG4108VW9 Membrane GQF42_RS09650 ENOG4105DEU major facilitator superfamily GQF42_RS09655 ENOG4105Q70 GQF42_RS09665 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GQF42_RS09675 ENOG4105EW9 transcriptional regulator AsnC family GQF42_RS09700 ENOG4105C1G acyl-Coa dehydrogenase GQF42_RS09760 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GQF42_RS09765 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GQF42_RS09770 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GQF42_RS09775 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GQF42_RS09790 ENOG4105E2R ROK family GQF42_RS09810 ENOG4105C2W permease GQF42_RS09860 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GQF42_RS09875 ENOG4105F38 ABC transporter, permease GQF42_RS09885 ENOG41073TP transcriptional regulator GQF42_RS09910 ENOG4105CUB amino acid GQF42_RS09935 ENOG4105DKT Transcriptional regulator GQF42_RS09940 ENOG4105DJV ribulose-phosphate 3-epimerase GQF42_RS09950 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GQF42_RS09965 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GQF42_RS09980 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GQF42_RS09990 ENOG4105SKN orotidine 5''-phosphate decarboxylase GQF42_RS09995 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GQF42_RS10000 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GQF42_RS10005 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GQF42_RS10015 ENOG4105CD3 dihydroorotase GQF42_RS10020 ENOG4105CXT aspartate transcarbamylase GQF42_RS10025 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GQF42_RS10035 ENOG410803B Involved in the transcription termination process (By similarity) GQF42_RS10040 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GQF42_RS10045 ENOG4105DC7 peptidase M24 GQF42_RS10055 ENOG4105D49 3-dehydroquinate synthase GQF42_RS10060 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GQF42_RS10065 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GQF42_RS10070 ENOG4105E2X shikimate dehydrogenase GQF42_RS10075 ENOG4105HHA aminodeoxychorismate lyase GQF42_RS10080 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GQF42_RS10085 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GQF42_RS10105 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GQF42_RS10120 ENOG4105CUT histidyl-tRNA synthetase GQF42_RS10130 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GQF42_RS10135 ENOG4105C99 atpase involved in dna repair GQF42_RS10140 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GQF42_RS10150 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GQF42_RS10155 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GQF42_RS10160 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GQF42_RS10170 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GQF42_RS10175 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GQF42_RS10180 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GQF42_RS10185 ENOG4105CDY transcriptional regulatory protein GQF42_RS10190 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GQF42_RS10195 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GQF42_RS10205 ENOG4105E2K Glycosyl transferase (Group 1 GQF42_RS10210 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase GQF42_RS10215 ENOG4108VTU Cdp-alcohol phosphatidyltransferase GQF42_RS10240 ENOG4105C22 threonyL-tRNA synthetase GQF42_RS10255 ENOG4108JDX DNA polymerase iii, epsilon subunit GQF42_RS10285 ENOG4105KF0 sporulation and cell division protein, SsgA GQF42_RS10315 ENOG4105F0I Aminotransferase GQF42_RS10370 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GQF42_RS10375 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GQF42_RS10390 ENOG4105D01 (LipO)protein GQF42_RS10395 ENOG4105D01 (LipO)protein GQF42_RS10400 ENOG4108UMI ABC transporter, permease GQF42_RS10405 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GQF42_RS10450 ENOG4105C57 major facilitator superfamily GQF42_RS10455 ENOG4105RJZ Transcriptional regulator GQF42_RS10465 ENOG4105CH7 arginosuccinase GQF42_RS10470 ENOG4105CDH Citrulline--aspartate ligase GQF42_RS10485 ENOG4105BZU Histidine kinase GQF42_RS10490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GQF42_RS10520 ENOG410836F Transposase GQF42_RS10525 ENOG4107SVN transposase GQF42_RS10530 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GQF42_RS10535 ENOG4105C8Y Acetylornithine aminotransferase GQF42_RS10540 ENOG4105CAS nag kinase GQF42_RS10545 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GQF42_RS10550 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GQF42_RS10565 ENOG4105VUF Transcriptional regulator GQF42_RS10595 ENOG4105T38 integral membrane protein GQF42_RS10605 ENOG4105F32 YngK protein GQF42_RS10620 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GQF42_RS10635 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GQF42_RS10640 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GQF42_RS10645 ENOG4105BZU Histidine kinase GQF42_RS10650 ENOG4108RWN rrna methyltransferase GQF42_RS10655 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GQF42_RS10660 ENOG41084BS 50S ribosomal protein L35 GQF42_RS10665 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GQF42_RS10720 ENOG4105C26 Dehydrogenase GQF42_RS10725 ENOG4105C5F glutamine synthetase GQF42_RS10735 ENOG4108Z86 Glutamine amidotransferase GQF42_RS10750 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GQF42_RS10760 ENOG4108HQS Glycine betaine GQF42_RS10765 ENOG4108IJ7 Glycine betaine GQF42_RS10770 ENOG4105HFS 5'-3' exonuclease GQF42_RS10790 ENOG4105D3G Pseudouridine synthase GQF42_RS10825 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GQF42_RS10830 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GQF42_RS10865 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GQF42_RS10875 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS10880 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GQF42_RS10885 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GQF42_RS10890 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) GQF42_RS10895 ENOG4105E5F proteasome GQF42_RS10900 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GQF42_RS10935 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS10940 ENOG4105DEF Extracellular solute-binding protein, family 5 GQF42_RS10945 ENOG4108J59 Extracellular solute-binding protein, family 5 GQF42_RS10950 ENOG4107URF beta-phospho-glucomutase GQF42_RS10955 ENOG4105C3R Methionine synthase GQF42_RS10960 ENOG4108K8U Glycerol operon regulatory protein GQF42_RS10965 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GQF42_RS10970 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GQF42_RS10975 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GQF42_RS10985 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GQF42_RS10990 ENOG4105JXH GntR family transcriptional regulator GQF42_RS11000 ENOG4105C8N cysteinyl-tRNA synthetase GQF42_RS11015 ENOG4108RH7 phosphoglycerate mutase GQF42_RS11020 ENOG4105D7N magnesium and cobalt transport protein CorA GQF42_RS11030 ENOG4105DYW oxidoreductase GQF42_RS11035 ENOG4105CPC Aldo Keto reductase GQF42_RS11055 ENOG4105S2J secreted protein GQF42_RS11065 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GQF42_RS11080 ENOG4105CD8 aminopeptidase N GQF42_RS11085 ENOG4105DCG PHP domain protein GQF42_RS11095 ENOG4105K5B UPF0225 protein GQF42_RS11100 ENOG4107EJG GntR family transcriptional regulator GQF42_RS11105 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GQF42_RS11110 ENOG4105C6Z Gluconate GQF42_RS11115 ENOG4105CHR reductase GQF42_RS11120 ENOG4105CPQ Dehydrogenase GQF42_RS11145 ENOG4105PTV Nudix Hydrolase GQF42_RS11150 ENOG4105VG5 Membrane GQF42_RS11175 ENOG4108IG5 Transcriptional regulator GQF42_RS11180 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS11190 ENOG4105EHZ conserved protein UCP016719 GQF42_RS11220 ENOG4108Z4X TRANSCRIPTIONal GQF42_RS11240 ENOG4105C1G acyl-Coa dehydrogenase GQF42_RS11285 ENOG4105D4T Citrate transporter GQF42_RS11290 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GQF42_RS11290 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GQF42_RS11295 ENOG4108SGK Tetr family transcriptional regulator GQF42_RS11305 ENOG4105F1J Homogentisate 1,2-dioxygenase GQF42_RS11310 ENOG4105FDP GntR family transcriptional regulator GQF42_RS11335 ENOG4105K6V RNA polymerase GQF42_RS11350 ENOG41061MD high-affinity nickel-transporter GQF42_RS11360 ENOG4108TCJ secreted hydrolase GQF42_RS11380 ENOG4107BJW polysaccharide deacetylase GQF42_RS11405 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GQF42_RS11460 ENOG4105C0B DNA polymerase III (alpha subunit) GQF42_RS11470 ENOG4106NMR serine protease GQF42_RS11480 ENOG4105CPU Monooxygenase GQF42_RS11500 ENOG4105EAD ABC transporter GQF42_RS11510 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GQF42_RS11515 ENOG4105C1G acyl-Coa dehydrogenase GQF42_RS11520 ENOG4105C57 major facilitator superfamily GQF42_RS11535 ENOG410841Q phosphoesterase PA-phosphatase related protein GQF42_RS11545 ENOG4105MS9 Resuscitation-promoting factor GQF42_RS11560 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GQF42_RS11570 ENOG4105CAT Cytidine monophosphate kinase GQF42_RS11580 ENOG4105KHN chorismate mutase GQF42_RS11595 ENOG410756H nucleotidyltransferase GQF42_RS11600 ENOG4105FE9 pseudouridine synthase GQF42_RS11605 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GQF42_RS11625 ENOG4105DCF alanine dehydrogenase GQF42_RS11635 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GQF42_RS11640 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GQF42_RS11645 ENOG4105BZP glycoside hydrolase 15-related GQF42_RS11670 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GQF42_RS11675 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GQF42_RS11695 ENOG4105E0A ABC, transporter GQF42_RS11700 ENOG4105TVJ transport system, permease GQF42_RS11705 ENOG4105DQ5 transport system permease protein GQF42_RS11710 ENOG4105DSU hydrolase GQF42_RS11745 ENOG4108VX5 3-methyladenine DNA glycosylase GQF42_RS11755 ENOG4108V1U phospholipid-binding protein GQF42_RS11775 ENOG4105DKW ABC transporter GQF42_RS11795 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS11800 ENOG4105BZU Histidine kinase GQF42_RS11805 ENOG4105EMU Dehydrogenase GQF42_RS11810 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GQF42_RS11820 ENOG4105IDI abc transporter atp-binding protein GQF42_RS11825 ENOG4105EAC phosphoserine phosphatase GQF42_RS11830 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GQF42_RS11845 ENOG4107YCY Transcriptional regulator GQF42_RS11875 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GQF42_RS11895 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GQF42_RS11900 ENOG4107QN1 sodium solute GQF42_RS11920 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F GQF42_RS11925 ENOG4105E2A Dehydrogenase GQF42_RS11960 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GQF42_RS11975 ENOG4105BZP glycoside hydrolase 15-related GQF42_RS11980 ENOG4105CHR reductase GQF42_RS12015 ENOG41060WC Enoyl-CoA hydratase GQF42_RS12025 ENOG4105C5H ABC transporter GQF42_RS12045 ENOG4107W7X Aldolase GQF42_RS12070 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GQF42_RS12075 ENOG4105CTK cobaltochelatase, cobn subunit GQF42_RS12085 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GQF42_RS12090 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GQF42_RS12105 ENOG4105CIA precorrin-4 C(11)-methyltransferase GQF42_RS12115 ENOG4105E4R Precorrin-3B C17-methyltransferase GQF42_RS12120 ENOG41081F0 Precorrin-8x methylmutase GQF42_RS12125 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GQF42_RS12150 ENOG4105EAD ABC transporter GQF42_RS12155 ENOG4106PMH Extracellular solute-binding protein family 3 GQF42_RS12160 ENOG4105C5R Aminotransferase GQF42_RS12175 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GQF42_RS12180 ENOG4108JPW Aminotransferase GQF42_RS12185 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GQF42_RS12190 ENOG4105EV8 ectoine hydroxylase GQF42_RS12215 ENOG4105C57 major facilitator superfamily GQF42_RS12230 ENOG4107HP6 Transcriptional regulator GQF42_RS12240 ENOG4105C7N Xanthine uracil vitamin C permease GQF42_RS12245 ENOG4105NAF rna polymerase sigma factor GQF42_RS12270 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GQF42_RS12275 ENOG4105DRR Transcriptional regulator, GntR family GQF42_RS12305 ENOG4105E9Z Nad-dependent epimerase dehydratase GQF42_RS12310 ENOG4105E98 transcriptional regulator DeoR family GQF42_RS12330 ENOG4105CPQ Dehydrogenase GQF42_RS12340 ENOG4105XEA Tetr family transcriptional regulator GQF42_RS12355 ENOG4107XBN GntR Family Transcriptional Regulator GQF42_RS12395 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GQF42_RS12400 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GQF42_RS12405 ENOG4108RFG Tetr family transcriptional regulator GQF42_RS12410 ENOG410814C multidrug resistance protein GQF42_RS12415 ENOG4105VG1 fes assembly suf system protein GQF42_RS12420 ENOG4108UNV SUF system FeS assembly protein, NifU family GQF42_RS12425 ENOG4105C9B Cysteine desulfurase GQF42_RS12430 ENOG4105C3K feS assembly ATPase SufC GQF42_RS12440 ENOG4105JRK feS assembly protein SufD GQF42_RS12455 ENOG4108AQF aminoglycoside N(3)-acetyltransferase GQF42_RS12460 ENOG4105CJ1 ABC, transporter GQF42_RS12470 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GQF42_RS12485 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GQF42_RS12495 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GQF42_RS12510 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) GQF42_RS12515 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GQF42_RS12520 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component GQF42_RS12530 ENOG4105CG3 alpha amylase, catalytic region GQF42_RS12535 ENOG4107T3P ABC, transporter GQF42_RS12540 ENOG4105U3E Transcriptional regulator GQF42_RS12545 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GQF42_RS12555 ENOG4107QP8 phosphohexose isomerase GQF42_RS12575 ENOG4105CP7 Triose-phosphate isomerase GQF42_RS12580 ENOG4105BZA Phosphoglycerate kinase GQF42_RS12585 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GQF42_RS12590 ENOG4105CIE May be required for sporulation (By similarity) GQF42_RS12595 ENOG4105CHW UPF0052 protein GQF42_RS12600 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GQF42_RS12605 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GQF42_RS12620 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GQF42_RS12625 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS12635 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GQF42_RS12645 ENOG4107VMB Beta-lactamase domain protein GQF42_RS12650 ENOG4107R0W ABC transporter GQF42_RS12655 ENOG4105E5Q amino acid AbC transporter GQF42_RS12665 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GQF42_RS12670 ENOG4105CSH Transporter GQF42_RS12695 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GQF42_RS12700 ENOG4105BZU Histidine kinase GQF42_RS12705 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GQF42_RS12710 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GQF42_RS12720 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GQF42_RS12725 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GQF42_RS12730 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GQF42_RS12735 ENOG4105D7N magnesium and cobalt transport protein CorA GQF42_RS12760 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GQF42_RS12765 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GQF42_RS12825 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GQF42_RS12830 ENOG4105DRR Transcriptional regulator, GntR family GQF42_RS12855 ENOG4108D32 Methyltransferase GQF42_RS12875 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GQF42_RS12885 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GQF42_RS12895 ENOG4105CQ7 ATP-dependent helicase GQF42_RS12935 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) GQF42_RS12955 ENOG4105C32 Amino acid ABC transporter (Permease) GQF42_RS12960 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GQF42_RS12965 ENOG4105C0Z ABC transporter GQF42_RS12970 ENOG4108IV0 ABC, transporter GQF42_RS13010 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GQF42_RS13015 ENOG41063TF transcriptional regulator (AraC GQF42_RS13035 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GQF42_RS13040 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GQF42_RS13045 ENOG4105E39 Enoyl-CoA hydratase GQF42_RS13060 ENOG4105EA8 2-Nitropropane dioxygenase GQF42_RS13065 ENOG4105F2C Acetyl-CoA acetyltransferase GQF42_RS13070 ENOG4108RZE Tetr family transcriptional regulator GQF42_RS13075 ENOG4105CHR reductase GQF42_RS13080 ENOG4105D2B acyl-CoA dehydrogenase GQF42_RS13090 ENOG4105MUA Resistance protein GQF42_RS13100 ENOG4105CBC glutamate synthase GQF42_RS13125 ENOG4108RVA ribokinase GQF42_RS13140 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GQF42_RS13150 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GQF42_RS13155 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GQF42_RS13165 ENOG4105DK0 Indole-3-glycerol phosphate synthase GQF42_RS13190 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GQF42_RS13200 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GQF42_RS13215 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GQF42_RS13220 ENOG4108176 endoribonuclease L-psp GQF42_RS13225 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GQF42_RS13230 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GQF42_RS13235 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GQF42_RS13240 ENOG4105CIH Imidazole acetol-phosphate transaminase GQF42_RS13245 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GQF42_RS13265 ENOG4108Z66 YbaK ebsC protein GQF42_RS13290 ENOG4105C0B DNA polymerase III (alpha subunit) GQF42_RS13335 ENOG41082BV acetyltransferase GQF42_RS13345 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GQF42_RS13350 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GQF42_RS13360 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GQF42_RS13365 ENOG4107VQS DivIVA family GQF42_RS13375 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GQF42_RS13380 ENOG4105DFA alanine racemase domain protein GQF42_RS13385 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GQF42_RS13390 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GQF42_RS13395 ENOG4105ME9 cell division protein FtsQ GQF42_RS13400 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GQF42_RS13410 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GQF42_RS13415 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GQF42_RS13420 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GQF42_RS13425 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GQF42_RS13430 ENOG4105CJN penicillin-binding protein GQF42_RS13440 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GQF42_RS13450 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GQF42_RS13480 ENOG4105CDA abc transporter atp-binding protein GQF42_RS13490 ENOG4107Z3H Transcriptional regulator, TetR family GQF42_RS13515 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GQF42_RS13540 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GQF42_RS13550 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GQF42_RS13560 ENOG4108UQY Iron-storage protein GQF42_RS13570 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GQF42_RS13580 ENOG4105C5I Dehydrogenase GQF42_RS13585 ENOG4105CTQ phosphohexokinase GQF42_RS13595 ENOG4105ENE Histidine kinase GQF42_RS13620 ENOG4105ED2 Beta-lactamase GQF42_RS13630 ENOG4105DKQ ROK family GQF42_RS13640 ENOG4105D0U Arsenite-activated ATPase (ArsA) GQF42_RS13665 ENOG4105JNK Glycosyl transferase (Group 1 GQF42_RS13715 ENOG4105C9B Cysteine desulfurase GQF42_RS13720 ENOG4108I0Q anthranilate phosphoribosyltransferase GQF42_RS13725 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GQF42_RS13730 ENOG4107EUI c reductase, iron-sulfur GQF42_RS13735 ENOG4107UDY cytochrome C GQF42_RS13740 ENOG4105CCU oxidase (Subunit III) GQF42_RS13755 ENOG4105MCD Part of cytochrome c oxidase, its function is GQF42_RS13760 ENOG4105BZ9 Cytochrome C oxidase, subunit I GQF42_RS13765 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GQF42_RS13795 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GQF42_RS13805 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS13810 ENOG4105BZU Histidine kinase GQF42_RS13845 ENOG4105C0H protease GQF42_RS13855 ENOG4108YZT Adenosylcobinamide kinase GQF42_RS13865 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GQF42_RS13870 ENOG4105CRK lysyL-tRNA synthetase GQF42_RS13885 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GQF42_RS13900 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GQF42_RS13920 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GQF42_RS13970 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GQF42_RS13975 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GQF42_RS13990 ENOG4105MXW flavin reductase domain protein, FMN-binding GQF42_RS14000 ENOG4105C5F glutamine synthetase GQF42_RS14015 ENOG4105CHJ isochorismatase hydrolase GQF42_RS14025 ENOG4105D0M Protease HtpX homolog GQF42_RS14045 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS14050 ENOG4108222 arsenate reductase GQF42_RS14055 ENOG4106SPC secreted protein GQF42_RS14070 ENOG4107R5B glutamine synthetase GQF42_RS14075 ENOG4107NHD transcriptional regulator GQF42_RS14085 ENOG4108XG2 Histidine kinase GQF42_RS14090 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS14125 ENOG41060BG Tetr family transcriptional regulator GQF42_RS14150 ENOG4105CG3 alpha amylase, catalytic region GQF42_RS14155 ENOG4105EG2 ABC transporter, permease GQF42_RS14160 ENOG4105D56 permease protein GQF42_RS14170 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS14180 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GQF42_RS14185 ENOG4105FBN Acid phosphatase GQF42_RS14200 ENOG4105C5F glutamine synthetase GQF42_RS14215 ENOG41081JD Transcriptional regulator GQF42_RS14260 ENOG4105F27 Major Facilitator GQF42_RS14275 ENOG4105C57 major facilitator superfamily GQF42_RS14280 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GQF42_RS14305 ENOG4107XZ0 Peptidase M50 GQF42_RS14360 ENOG4106A0S GQF42_RS14380 ENOG4107S1E Beta-lactamase GQF42_RS14385 ENOG4105C2C drug resistance transporter, Bcr CflA GQF42_RS14420 ENOG4108VGI doxx family GQF42_RS14450 ENOG4105E7U AraC family transcriptional regulator GQF42_RS14475 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GQF42_RS14480 ENOG4107XFJ UPF0246 protein GQF42_RS14485 ENOG4108UHU Aldolase GQF42_RS14490 ENOG4105CVJ phosphoglycerate mutase GQF42_RS14500 ENOG4105EGD dinuclear metal center protein, YbgI family GQF42_RS14510 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GQF42_RS14525 ENOG4105BZU Histidine kinase GQF42_RS14535 ENOG4108S01 response regulator GQF42_RS14550 ENOG4105CHU acetyl-coa acetyltransferase GQF42_RS14565 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GQF42_RS14575 ENOG4105DYW oxidoreductase GQF42_RS14590 ENOG4107QVI Methyltransferase, type 11 GQF42_RS14595 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GQF42_RS14600 ENOG4108SGK Tetr family transcriptional regulator GQF42_RS14665 ENOG4108JJB ABC transporter GQF42_RS14680 ENOG4105XPP Protein of unknown function (DUF1275) GQF42_RS14685 ENOG4106A3M Cytochrome p-450 GQF42_RS14690 ENOG4105F2C Acetyl-CoA acetyltransferase GQF42_RS14700 ENOG4105CSH Transporter GQF42_RS14710 ENOG4107ZBN O-methyltransferase GQF42_RS14730 ENOG4105WQG acetyltransferase GQF42_RS14745 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GQF42_RS14820 ENOG4105BZ4 penicillin-binding protein GQF42_RS14835 ENOG4105DAX Pfam:DUF2983 GQF42_RS14880 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GQF42_RS14905 ENOG4105VUF Transcriptional regulator GQF42_RS14935 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GQF42_RS14940 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GQF42_RS14960 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GQF42_RS14970 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GQF42_RS14980 ENOG4105EXN Sulfate transport protein CysZ GQF42_RS14990 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GQF42_RS14995 ENOG4108ZHJ Organic hydroperoxide resistance protein GQF42_RS15010 ENOG4105CXK mandelate racemase muconate lactonizing GQF42_RS15025 ENOG4105DFW ABC transporter GQF42_RS15035 ENOG4108HWW ABC transporter GQF42_RS15040 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GQF42_RS15045 ENOG4105CIH Imidazole acetol-phosphate transaminase GQF42_RS15085 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GQF42_RS15090 ENOG4105J4Q Transcriptional regulator GQF42_RS15105 ENOG4106NZI LysR family Transcriptional regulator GQF42_RS15115 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS15120 ENOG4105D8K carboxyl transferase GQF42_RS15165 ENOG4108YXU transcriptional regulator AsnC family GQF42_RS15180 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GQF42_RS15200 ENOG4105C8V SAICAR synthetase GQF42_RS15205 ENOG4105CHR reductase GQF42_RS15220 ENOG4105C3R Methionine synthase GQF42_RS15235 ENOG4105C9B Cysteine desulfurase GQF42_RS15250 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GQF42_RS15315 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GQF42_RS15320 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GQF42_RS15330 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GQF42_RS15340 ENOG4108UB4 uncharacterized protein ygjQ GQF42_RS15380 ENOG4107QZF nitrite reductase NADPH large subunit GQF42_RS15390 ENOG4108IND Tetr family transcriptional regulator GQF42_RS15395 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GQF42_RS15400 ENOG4105DRS transport system, permease GQF42_RS15410 ENOG4107FKK extracellular solute-binding protein family 1 GQF42_RS15430 ENOG4107ZVI PhiRv2 prophage protein GQF42_RS15500 ENOG4108KWP DNA-binding transcriptional regulator GlcC GQF42_RS15535 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GQF42_RS15540 ENOG4105E2R ROK family GQF42_RS15595 ENOG4108FN7 Aldo keto reductase GQF42_RS15605 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GQF42_RS15610 ENOG4105DSE periplasmic solute binding protein GQF42_RS15615 ENOG4105FDK ABC transporter GQF42_RS15635 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GQF42_RS15640 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GQF42_RS15645 ENOG4105DEF Extracellular solute-binding protein, family 5 GQF42_RS15660 ENOG4108JQ7 (ABC) transporter GQF42_RS15665 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GQF42_RS15675 ENOG4108478 ec 3.2.1.18 GQF42_RS15690 ENOG4105ENE Histidine kinase GQF42_RS15695 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS15705 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GQF42_RS15715 ENOG4105D4Y metalloprotease GQF42_RS15745 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GQF42_RS15790 ENOG4107WMG L,D-carboxypeptidase GQF42_RS15795 ENOG4105MSB protein, conserved in bacteria GQF42_RS15805 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GQF42_RS15820 ENOG4105EQX glucarate dehydratase GQF42_RS15825 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GQF42_RS15840 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GQF42_RS15845 ENOG4107YU2 histidine triad (hIT) protein GQF42_RS15850 ENOG4107RE3 peptidase, S41 GQF42_RS15870 ENOG4107QWG 2-Nitropropane dioxygenase GQF42_RS15875 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GQF42_RS15880 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GQF42_RS15915 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GQF42_RS15925 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GQF42_RS15940 ENOG4108YYC ycei family GQF42_RS15945 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GQF42_RS16095 ENOG41060M0 Crispr-associated protein, cse4 family GQF42_RS16120 ENOG4105JXH GntR family transcriptional regulator GQF42_RS16170 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GQF42_RS16175 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GQF42_RS16190 ENOG4105MP0 transposase GQF42_RS16230 ENOG4105EPR degv family GQF42_RS16240 ENOG4105C8T Leucyl-tRNA synthetase GQF42_RS16250 ENOG4107QIZ NADH dehydrogenase GQF42_RS16275 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GQF42_RS16280 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GQF42_RS16290 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GQF42_RS16295 ENOG4105D0M Protease HtpX homolog GQF42_RS16310 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GQF42_RS16320 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GQF42_RS16340 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GQF42_RS16345 ENOG4105K46 50S ribosomal protein l27 GQF42_RS16350 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GQF42_RS16355 ENOG4105C03 ribonuclease GQF42_RS16500 ENOG41066UM arsR family transcriptional regulator GQF42_RS16520 ENOG41082YX Transcriptional regulator, arsr family GQF42_RS16525 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GQF42_RS16600 ENOG4105CNI cell division protein FtsW GQF42_RS16605 ENOG4105CJN penicillin-binding protein GQF42_RS16620 ENOG4105DFF Rod shape-determining protein mreb GQF42_RS16625 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GQF42_RS16635 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GQF42_RS16640 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GQF42_RS16650 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GQF42_RS16655 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GQF42_RS16660 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GQF42_RS16665 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GQF42_RS16760 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GQF42_RS16775 ENOG4108TGC Acyltransferase GQF42_RS16795 ENOG4108YZG isomerase GQF42_RS16800 ENOG4105C85 amino acid GQF42_RS16820 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GQF42_RS16825 ENOG4105E2Y ABC, transporter GQF42_RS16830 ENOG4105CPU Monooxygenase GQF42_RS16840 ENOG4105C85 amino acid GQF42_RS16845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GQF42_RS16850 ENOG4107R13 MMPL domain protein GQF42_RS16855 ENOG4105ENE Histidine kinase GQF42_RS16860 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS16865 ENOG4105MC2 DSBA oxidoreductase GQF42_RS16880 ENOG4108TCJ secreted hydrolase GQF42_RS16910 ENOG4108UYE Lactoylglutathione lyase GQF42_RS16950 ENOG4106NZI LysR family Transcriptional regulator GQF42_RS16960 ENOG4108KTG Membrane protein, drug metabolite transporter GQF42_RS17000 ENOG4105D8X mechanosensitive ion channel GQF42_RS17005 ENOG4105E2R ROK family GQF42_RS17015 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component GQF42_RS17020 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GQF42_RS17025 ENOG4105F8D glycoside hydrolase family 4 GQF42_RS17040 ENOG4105CT1 (ABC) transporter GQF42_RS17070 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GQF42_RS17105 ENOG4105VHU single-stranded DNA-binding protein GQF42_RS17125 ENOG4108JQ1 Dehydrogenase GQF42_RS17180 ENOG4105JNK Glycosyl transferase (Group 1 GQF42_RS17185 ENOG4105D3Q Sugar transferase GQF42_RS17195 ENOG4105CJR Integral membrane protein (MviN GQF42_RS17205 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GQF42_RS17225 ENOG4105C3M thioredoxin reductase GQF42_RS17230 ENOG4105S2J secreted protein GQF42_RS17265 ENOG4105CJ1 ABC, transporter GQF42_RS17275 ENOG4105C26 Dehydrogenase GQF42_RS17280 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GQF42_RS17285 ENOG4105DH8 myo-inositol catabolism GQF42_RS17295 ENOG4105EDK PfkB domain protein GQF42_RS17305 ENOG4105D9U N-acetyltransferase GQF42_RS17340 ENOG4105C7H Helicase, RecD TraA family GQF42_RS17355 ENOG4107RA9 decarboxylase GQF42_RS17375 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS17380 ENOG4105C2J ABC transporter GQF42_RS17385 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GQF42_RS17390 ENOG4108RVA ribokinase GQF42_RS17395 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GQF42_RS17435 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS17450 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GQF42_RS17460 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GQF42_RS17465 ENOG4105D17 glycoside hydrolase, family 3 domain protein GQF42_RS17515 ENOG4105EDW glycosyl transferase, family 39 GQF42_RS17520 ENOG4105C7K acetolactate synthase GQF42_RS17530 ENOG4105CK7 Sodium proline symporter GQF42_RS17540 ENOG4108XFF GQF42_RS17550 ENOG4105C29 acyl-CoA thioesterase GQF42_RS17565 ENOG4107QX3 carboxylase GQF42_RS17575 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GQF42_RS17580 ENOG4105C1G acyl-Coa dehydrogenase GQF42_RS17600 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GQF42_RS17610 ENOG4105DUU IucA IucC family protein GQF42_RS17615 ENOG4105E2D ec 3.2.1.52 GQF42_RS17630 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GQF42_RS17650 ENOG4105ECQ AraC Family Transcriptional Regulator GQF42_RS17655 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GQF42_RS17665 ENOG41062D9 Histidine kinase GQF42_RS17675 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GQF42_RS17680 ENOG4105C1B dTDP-glucose 4-6-dehydratase GQF42_RS17685 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS17700 ENOG4105DRS transport system, permease GQF42_RS17710 ENOG4108NNZ chitinase GQF42_RS17730 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GQF42_RS17745 ENOG4105CVJ phosphoglycerate mutase GQF42_RS17790 ENOG4105BZU Histidine kinase GQF42_RS17795 ENOG4105DEN Luciferase family GQF42_RS17815 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GQF42_RS17855 ENOG4105J5T Amp-dependent synthetase and ligase GQF42_RS17860 ENOG4108M1A Chitin-binding protein GQF42_RS17895 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GQF42_RS17915 ENOG4105CY5 solute-binding protein GQF42_RS17920 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component GQF42_RS17930 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GQF42_RS17940 ENOG4105MWK D-amino acid dehydrogenase, small subunit GQF42_RS17945 ENOG41080U6 GntR family transcriptional regulator GQF42_RS17960 ENOG4105D9R oxidoreductase GQF42_RS17965 ENOG41090KN UPF0303 protein GQF42_RS17990 ENOG4107YPT transcriptional regulator GQF42_RS18000 ENOG4108U4N (sortase) family GQF42_RS18015 ENOG4108PJD permease GQF42_RS18025 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GQF42_RS18060 ENOG4105ECY inositol monophosphatase GQF42_RS18070 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GQF42_RS18085 ENOG4105CSH Transporter GQF42_RS18090 ENOG4106BRA Membrane GQF42_RS18100 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GQF42_RS18130 ENOG4105KPY Small multidrug resistance protein GQF42_RS18135 ENOG4105BZ4 penicillin-binding protein GQF42_RS18165 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GQF42_RS18170 ENOG4105CI1 PTS System GQF42_RS18180 ENOG4105CI1 PTS System GQF42_RS18185 ENOG4108RQ5 Beta-lactamase domain-containing protein GQF42_RS18220 ENOG4105C85 amino acid GQF42_RS18230 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GQF42_RS18240 ENOG4108RWI nicotinamidase GQF42_RS18250 ENOG4107G87 m6 family metalloprotease domain protein GQF42_RS18270 ENOG4105KF0 sporulation and cell division protein, SsgA GQF42_RS18275 ENOG4105CQB FAD linked oxidase domain protein GQF42_RS18285 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GQF42_RS18295 ENOG4105E90 ABC transporter GQF42_RS18300 ENOG4108IJ8 ABC transporter GQF42_RS18305 ENOG4105E90 ABC transporter GQF42_RS18360 ENOG4105E2D ec 3.2.1.52 GQF42_RS18375 ENOG4108UJU UPF0301 protein GQF42_RS18380 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GQF42_RS18385 ENOG4108426 dNA-binding protein GQF42_RS18395 ENOG4105EEM helicase GQF42_RS18420 ENOG4105DQQ Major facilitator superfamily MFS_1 GQF42_RS18425 ENOG4106YYS transcriptional regulatory protein GQF42_RS18430 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GQF42_RS18440 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GQF42_RS18450 ENOG4106NZI LysR family Transcriptional regulator GQF42_RS18460 ENOG4106A3M Cytochrome p-450 GQF42_RS18465 ENOG4107E6A Cytochrome p-450 GQF42_RS18475 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GQF42_RS18480 ENOG4105CN1 protease GQF42_RS18485 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) GQF42_RS18490 ENOG4105CAK Cell division ATP-binding protein ftsE GQF42_RS18505 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GQF42_RS18510 ENOG4108QVN serine threonine protein kinase GQF42_RS18515 ENOG4108UGD Serine Threonine protein kinase GQF42_RS18535 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GQF42_RS18540 ENOG4105K64 Glycosyl transferase, family 2 GQF42_RS18545 ENOG4107SJB teichoic acid biosynthesis GQF42_RS18550 ENOG4107SJB teichoic acid biosynthesis GQF42_RS18555 ENOG4108ZHJ Organic hydroperoxide resistance protein GQF42_RS18560 ENOG4105K56 Transcriptional regulator GQF42_RS18600 ENOG4105EY8 ABC transporter GQF42_RS18605 ENOG4107SJB teichoic acid biosynthesis GQF42_RS18625 ENOG4105C7I Dehydrogenase GQF42_RS18650 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GQF42_RS18660 ENOG4105T0Z Conserved Protein GQF42_RS18665 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS18670 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GQF42_RS18680 ENOG4105G3P Lipoprotein lpqB GQF42_RS18685 ENOG4105BZU Histidine kinase GQF42_RS18690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GQF42_RS18710 ENOG4108WQ6 secreted protein GQF42_RS18715 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GQF42_RS18755 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GQF42_RS18765 ENOG4105DM4 PTS System GQF42_RS18770 ENOG4107QYR Signal peptidase i GQF42_RS18780 ENOG4105EIP mannose-6-phosphate isomerase GQF42_RS18790 ENOG4105W49 UPF0434 protein GQF42_RS18815 ENOG4107RGC Glycosyl transferase, family 2 GQF42_RS18820 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GQF42_RS18830 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase GQF42_RS18835 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) GQF42_RS18845 ENOG4107V9E glucose-1-phosphate thymidylyltransferase GQF42_RS18865 ENOG4108KGH TRANSCRIPTIONal GQF42_RS18870 ENOG4108KGH TRANSCRIPTIONal GQF42_RS18880 ENOG4108KGH TRANSCRIPTIONal GQF42_RS18890 ENOG4108KGH TRANSCRIPTIONal GQF42_RS18905 ENOG4105C6Y Udp-glucose 6-dehydrogenase GQF42_RS18920 ENOG4108Z6Z Transcriptional regulator GQF42_RS18935 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GQF42_RS18950 ENOG41065SU Two-component system sensor kinase GQF42_RS18955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GQF42_RS18960 ENOG4105DUX Transporter GQF42_RS18990 ENOG41082AN stage II sporulation protein GQF42_RS18995 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GQF42_RS19005 ENOG4105CI2 imidazolone-5-propionate hydrolase GQF42_RS19020 ENOG4105CGP Urocanate hydratase GQF42_RS19060 ENOG4105C84 Histidine ammonia-lyase GQF42_RS19065 ENOG4108IJ8 ABC transporter GQF42_RS19070 ENOG4105E90 ABC transporter GQF42_RS19075 ENOG4105E90 ABC transporter GQF42_RS19100 ENOG4105EMU Dehydrogenase GQF42_RS19120 ENOG4105CHU acetyl-coa acetyltransferase GQF42_RS19155 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GQF42_RS19160 ENOG4107RBB ABC transporter, permease GQF42_RS19165 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GQF42_RS19170 ENOG4105CEP NADH dehydrogenase GQF42_RS19190 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GQF42_RS19200 ENOG4105MS9 Resuscitation-promoting factor GQF42_RS19205 ENOG4106A3M Cytochrome p-450 GQF42_RS19270 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GQF42_RS19275 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GQF42_RS19280 ENOG4105C0R drug resistance transporter emrb qaca subfamily GQF42_RS19290 ENOG4107QN1 sodium solute GQF42_RS19355 ENOG4105BZU Histidine kinase GQF42_RS19370 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GQF42_RS19375 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GQF42_RS19380 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GQF42_RS19385 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GQF42_RS19395 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GQF42_RS19405 ENOG41067SE Tetr family transcriptional regulator GQF42_RS19420 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GQF42_RS19425 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GQF42_RS19430 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS19445 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GQF42_RS19485 ENOG4105C5H ABC transporter GQF42_RS19495 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GQF42_RS19500 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GQF42_RS19505 ENOG41069ER domain protein GQF42_RS19510 ENOG4105F8V Hydrolase, tatD family GQF42_RS19545 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GQF42_RS19555 ENOG4108JJB ABC transporter GQF42_RS19560 ENOG4105K56 Transcriptional regulator GQF42_RS19565 ENOG4108ZHJ Organic hydroperoxide resistance protein GQF42_RS19580 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GQF42_RS19620 ENOG4105EYF MMPL domain protein GQF42_RS19640 ENOG4108R85 Short chain dehydrogenase GQF42_RS19645 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GQF42_RS19650 ENOG4105F95 Monooxygenase GQF42_RS19660 ENOG4105CGK Exodeoxyribonuclease III GQF42_RS19680 ENOG4105D9U N-acetyltransferase GQF42_RS19685 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GQF42_RS19690 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GQF42_RS19700 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GQF42_RS19705 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GQF42_RS19715 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GQF42_RS19725 ENOG4105C0R drug resistance transporter emrb qaca subfamily GQF42_RS19735 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GQF42_RS19745 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GQF42_RS19780 ENOG4105DM4 PTS System GQF42_RS19790 ENOG410804X Transcriptional regulator GQF42_RS19815 ENOG4108Z6Z Transcriptional regulator GQF42_RS19825 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GQF42_RS19855 ENOG4107HP6 Transcriptional regulator GQF42_RS19865 ENOG4105VTR Integrase GQF42_RS19915 ENOG4105CZE histidine utilization repressor GQF42_RS19955 ENOG4107R08 Integrase GQF42_RS20000 ENOG4105CHR reductase GQF42_RS20030 ENOG4108FKE two-component system sensor kinase GQF42_RS20040 ENOG4108RQS Two component transcriptional regulator (Winged helix family GQF42_RS20050 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GQF42_RS20055 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GQF42_RS20065 ENOG4105ES5 Histidine kinase GQF42_RS20070 ENOG4108YV4 Universal stress protein GQF42_RS20100 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GQF42_RS20130 ENOG4105ETX regulatoR GQF42_RS20135 ENOG41062D9 Histidine kinase GQF42_RS20185 ENOG4108V06 Glutathione peroxidase GQF42_RS20205 ENOG41061WM D-Alanyl-D-Alanine GQF42_RS20285 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GQF42_RS20305 ENOG4105C26 Dehydrogenase GQF42_RS20345 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS20370 ENOG4108762 serine threonine protein kinase GQF42_RS20380 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GQF42_RS20385 ENOG4108ZRZ Transcriptional regulator (AsnC family) GQF42_RS20390 ENOG4105N14 lysine exporter protein LysE YggA GQF42_RS20400 ENOG4105D2B acyl-CoA dehydrogenase GQF42_RS20445 ENOG4105H3G oxidoreductase GQF42_RS20450 ENOG4105CMV Succinyl-CoA synthetase subunit beta GQF42_RS20455 ENOG4105CGU Enoyl-CoA hydratase GQF42_RS20465 ENOG4105D2S major facilitator superfamily GQF42_RS20485 ENOG4105CC9 acyl-Coa dehydrogenase GQF42_RS20510 ENOG4105D2B acyl-CoA dehydrogenase GQF42_RS20515 ENOG4105CC9 acyl-Coa dehydrogenase GQF42_RS20525 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS20540 ENOG4105WN5 stage II sporulation protein GQF42_RS20580 ENOG4108XEP Alpha Beta Hydrolase Fold protein GQF42_RS20590 ENOG4108SU4 UPF0309 protein GQF42_RS20605 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GQF42_RS20630 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS20645 ENOG4107QX3 carboxylase GQF42_RS20660 ENOG4105C6K Malic enzyme GQF42_RS20675 ENOG4105CQB FAD linked oxidase domain protein GQF42_RS20680 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GQF42_RS20705 ENOG4105CPC Aldo Keto reductase GQF42_RS20710 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GQF42_RS20740 ENOG4105C7N Xanthine uracil vitamin C permease GQF42_RS20750 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GQF42_RS20780 ENOG4108N0W Major Facilitator superfamily GQF42_RS20790 ENOG4108UIH futalosine nucleosidase GQF42_RS20795 ENOG4105E63 Pfam:DUF178 GQF42_RS20800 ENOG4105VEQ Cold shock protein GQF42_RS20825 ENOG4105CFI type iii restriction protein res subunit GQF42_RS20835 ENOG4105EEM helicase GQF42_RS20845 ENOG4106N3A copper homeostasis protein cutc GQF42_RS20870 ENOG4105QEK Transcriptional regulator GQF42_RS20875 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GQF42_RS20880 ENOG4105C5Y PTS System GQF42_RS20915 ENOG4105EBR Carboxylesterase GQF42_RS20925 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GQF42_RS20930 ENOG4105VEQ Cold shock protein GQF42_RS20945 ENOG4105C3Q Glycosyl transferase, family 2 GQF42_RS20955 ENOG4108K4C ec 3.1.3.12 GQF42_RS20975 ENOG4105CE4 GlcNAc 6-P deacetylase GQF42_RS20980 ENOG4106VEM tagatose-6-phosphate kinase GQF42_RS20990 ENOG4105BZU Histidine kinase GQF42_RS21010 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GQF42_RS21115 ENOG4108IJ9 (ABC) transporter GQF42_RS21125 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GQF42_RS21135 ENOG4105C2N RNA methyltransferase TrmH family group 3 GQF42_RS21140 ENOG4105C8N cysteinyl-tRNA synthetase GQF42_RS21145 ENOG410905P Pyridoxamine 5-phosphate GQF42_RS21150 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GQF42_RS21155 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GQF42_RS21160 ENOG4108VJ1 Transcriptional regulator (CarD family GQF42_RS21180 ENOG4105BZU Histidine kinase GQF42_RS21200 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GQF42_RS21305 ENOG4105QNJ serralysin (EC 3.4.24.40) GQF42_RS21310 ENOG4108YZJ Pfam:DUF2596 GQF42_RS21315 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GQF42_RS21360 ENOG4107SQD Transcriptional regulator, GntR family GQF42_RS21365 ENOG4105N14 lysine exporter protein LysE YggA GQF42_RS21370 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GQF42_RS21375 ENOG4105JSC dimethylmenaquinone methyltransferase GQF42_RS21385 ENOG4105YIP Tetr family transcriptional regulator GQF42_RS21395 ENOG4105HHS UPF0256 protein GQF42_RS21405 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GQF42_RS21410 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GQF42_RS21430 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GQF42_RS21515 ENOG4105KHC sulfurtransferase GQF42_RS21520 ENOG4105PKJ carbohydrate binding GQF42_RS21540 ENOG4107NHD transcriptional regulator GQF42_RS21545 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS21550 ENOG4105C0H protease GQF42_RS21560 ENOG4105ETX regulatoR GQF42_RS21580 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GQF42_RS21585 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GQF42_RS21595 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GQF42_RS21615 ENOG4105VPX protein, conserved in bacteria GQF42_RS21625 ENOG4105CJ3 phosphate transporter GQF42_RS21630 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GQF42_RS21650 ENOG4105DNP FAD linked oxidase domain protein GQF42_RS21655 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GQF42_RS21660 ENOG4107SN7 NLP P60 protein GQF42_RS21675 ENOG4107FW0 short-chain dehydrogenase reductase GQF42_RS21760 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GQF42_RS21770 ENOG4105CEP NADH dehydrogenase GQF42_RS21800 ENOG4105D5U fad dependent oxidoreductase GQF42_RS21805 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GQF42_RS21815 ENOG4105CPC Aldo Keto reductase GQF42_RS21845 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GQF42_RS21850 ENOG4105C0R drug resistance transporter emrb qaca subfamily GQF42_RS21880 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GQF42_RS21935 ENOG4105C1J atp-dependent rna helicase GQF42_RS21975 ENOG4105CQ7 ATP-dependent helicase GQF42_RS21995 ENOG4108TAC GQF42_RS22010 ENOG4105CXB phosphoribosylaminoimidazole synthetase GQF42_RS22030 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GQF42_RS22035 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GQF42_RS22040 ENOG410839H phosphoribosylformylglycinamidine synthase GQF42_RS22070 ENOG4105BZU Histidine kinase GQF42_RS22085 ENOG4105C8V SAICAR synthetase GQF42_RS22105 ENOG4105C12 Phosphoribosylglycinamide synthetase GQF42_RS22130 ENOG4108T5E Copper resistance protein GQF42_RS22135 ENOG4105CHR reductase GQF42_RS22180 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GQF42_RS22195 ENOG4108Z6B deaminase GQF42_RS22210 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein GQF42_RS22215 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GQF42_RS22220 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GQF42_RS22235 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GQF42_RS22245 ENOG4108YYC ycei family GQF42_RS22250 ENOG410905P Pyridoxamine 5-phosphate GQF42_RS22260 ENOG4105C57 major facilitator superfamily GQF42_RS22265 ENOG4105EDW glycosyl transferase, family 39 GQF42_RS22275 ENOG4105BZU Histidine kinase GQF42_RS22280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GQF42_RS22295 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) GQF42_RS22340 ENOG4108UXN response regulator GQF42_RS22355 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS22360 ENOG4105NAF rna polymerase sigma factor GQF42_RS22415 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GQF42_RS22435 ENOG4107T6F Xaa-Pro aminopeptidase GQF42_RS22440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GQF42_RS22475 ENOG4105DBE peroxidase GQF42_RS22480 ENOG4105CQC Prephenate dehydratase GQF42_RS22485 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GQF42_RS22490 ENOG410667J hydrolase GQF42_RS22535 ENOG4107SWG transcriptional regulator MERR family GQF42_RS22540 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) GQF42_RS22555 ENOG410667J hydrolase GQF42_RS22565 ENOG4108JJ9 ABC, transporter GQF42_RS22570 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GQF42_RS22575 ENOG4105C4M (Ubiquinol oxidase) subunit I GQF42_RS22585 ENOG4105CIH Imidazole acetol-phosphate transaminase GQF42_RS22590 ENOG4107P2S Transcriptional regulator GQF42_RS22615 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GQF42_RS22640 ENOG4106048 Cupin 2, conserved barrel domain protein GQF42_RS22645 ENOG41082T9 Membrane GQF42_RS22650 ENOG4105KJF protein tyrosine phosphatase GQF42_RS22655 ENOG4105C28 cystathionine GQF42_RS22690 ENOG4105F27 Major Facilitator GQF42_RS22715 ENOG4105CDU Replicative dna helicase GQF42_RS22725 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GQF42_RS22730 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GQF42_RS22735 ENOG4107YH6 single-stranded DNA-binding protein GQF42_RS22740 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GQF42_RS22765 ENOG4105BZ4 penicillin-binding protein GQF42_RS22805 ENOG4105D9P serine threonine protein kinase GQF42_RS22820 ENOG4105C3M thioredoxin reductase GQF42_RS22825 ENOG4105K63 Thioredoxin GQF42_RS22840 ENOG4107QJE Chromosome Partitioning Protein GQF42_RS22845 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GQF42_RS22855 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GQF42_RS22860 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GQF42_RS22865 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GQF42_RS22880 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GQF42_RS22885 ENOG4108J5G 6-phosphogluconate dehydrogenase GQF42_RS22890 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GQF42_RS22895 ENOG4105K7N UPF0232 protein GQF42_RS22900 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GQF42_RS22905 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GQF42_RS22930 ENOG4105GFG DUF218 domain GQF42_RS22940 ENOG4108KQ5 Integrase catalytic subunit GQF42_RS22960 ENOG4108HMN Caspase domain GQF42_RS22995 ENOG4108UGD Serine Threonine protein kinase GQF42_RS23025 ENOG4105ZJT Cell division protein CrgA GQF42_RS23035 ENOG4108U4N (sortase) family GQF42_RS23050 ENOG4108U4N (sortase) family GQF42_RS23055 ENOG4108RN7 integral membrane protein GQF42_RS23065 ENOG4105CJN penicillin-binding protein GQF42_RS23080 ENOG4105HZM Fha domain containing protein GQF42_RS23085 ENOG4105TV9 FHA Domain-Containing protein GQF42_RS23115 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GQF42_RS23120 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GQF42_RS23125 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GQF42_RS23130 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GQF42_RS23135 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GQF42_RS23150 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GQF42_RS23160 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GQF42_RS23165 ENOG4108IG5 Transcriptional regulator GQF42_RS23185 ENOG4107QSN dihydrolipoamide acetyltransferase GQF42_RS23230 ENOG4107QPV Serine Threonine protein kinase GQF42_RS23255 ENOG4105CPP Dehydrogenase, E1 component GQF42_RS23260 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GQF42_RS23325 ENOG4107QNK )-transporter GQF42_RS23345 ENOG4105ECQ AraC Family Transcriptional Regulator GQF42_RS23350 ENOG41082W1 Cupin 2, conserved barrel domain protein GQF42_RS23360 ENOG4105DFM M18 family aminopeptidase GQF42_RS23365 ENOG4105CSU acyl-Coa dehydrogenase GQF42_RS23380 ENOG4105EUB pirin domain protein GQF42_RS23395 ENOG4105C9M aspartyl-trna synthetase GQF42_RS23415 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GQF42_RS23425 ENOG4105EM2 membrane GQF42_RS23450 ENOG4105CH2 amidohydrolase GQF42_RS23470 ENOG4105C22 threonyL-tRNA synthetase GQF42_RS23475 ENOG4105DU0 nucleoside hydrolase GQF42_RS23480 ENOG4105CG3 alpha amylase, catalytic region GQF42_RS23500 ENOG4105BZ9 Cytochrome C oxidase, subunit I GQF42_RS23510 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GQF42_RS23570 ENOG4105CTZ aminopeptidase c GQF42_RS23590 ENOG41080V3 Major Facilitator superfamily GQF42_RS23630 ENOG4107STQ Multicopper oxidase GQF42_RS23640 ENOG4105JAB phenazine biosynthesis protein, phzf family GQF42_RS23655 ENOG4105C1J atp-dependent rna helicase GQF42_RS23660 ENOG4105VEQ Cold shock protein GQF42_RS23690 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GQF42_RS23745 ENOG4105DHP deoxycytidine triphosphate deaminase GQF42_RS23750 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GQF42_RS23780 ENOG4105DF6 Fe-S oxidoreductase GQF42_RS23790 ENOG4105CFG Acts as a chaperone (By similarity) GQF42_RS23795 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GQF42_RS23800 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GQF42_RS23805 ENOG4105KNI merR family transcriptional Regulator GQF42_RS23810 ENOG4105DFW ABC transporter GQF42_RS23835 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GQF42_RS23860 ENOG4105D9P serine threonine protein kinase GQF42_RS23895 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GQF42_RS23910 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GQF42_RS23930 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) GQF42_RS23935 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GQF42_RS23955 ENOG4105BZU Histidine kinase GQF42_RS23960 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS23965 ENOG4105BZU Histidine kinase GQF42_RS23970 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS23980 ENOG4105DIM ABC transporter GQF42_RS23985 ENOG4105CIG ABC transporter GQF42_RS24005 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GQF42_RS24015 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GQF42_RS24030 ENOG4108WYP Transcriptional regulator GQF42_RS24035 ENOG4108JPW Aminotransferase GQF42_RS24040 ENOG4108V4B ThiJ pfpI GQF42_RS24050 ENOG4108762 serine threonine protein kinase GQF42_RS24065 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GQF42_RS24070 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GQF42_RS24090 ENOG4105CFH Aspartokinase GQF42_RS24100 ENOG4105NAF rna polymerase sigma factor GQF42_RS24130 ENOG4108PJD permease GQF42_RS24190 ENOG4105C0X amino acid GQF42_RS24200 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GQF42_RS24205 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GQF42_RS24210 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GQF42_RS24240 ENOG4105C0X amino acid GQF42_RS24270 ENOG4105KTH gatB Yqey GQF42_RS24315 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GQF42_RS24335 ENOG4105P8F nudix hydrolase GQF42_RS24345 ENOG4105D74 hydrolase GQF42_RS24360 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GQF42_RS24410 ENOG4108FPN Integrase GQF42_RS24465 ENOG4108I5C dEAD DEAH box helicase GQF42_RS24470 ENOG4105WN5 stage II sporulation protein GQF42_RS24480 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for GQF42_RS24490 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GQF42_RS24500 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GQF42_RS24505 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GQF42_RS24550 ENOG4105C2M dna polymerase I GQF42_RS24570 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GQF42_RS24575 ENOG4105KDC 50s ribosomal protein l28 GQF42_RS24585 ENOG4105NRA 50s ribosomal protein l31 type b GQF42_RS24595 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GQF42_RS24605 ENOG41082YX Transcriptional regulator, arsr family GQF42_RS24630 ENOG4105C26 Dehydrogenase GQF42_RS24665 ENOG4105CVK Glutamate decarboxylase GQF42_RS24675 ENOG4107TXC Transcriptional regulator GQF42_RS24680 ENOG41082VC UPF0145 protein GQF42_RS24695 ENOG4105F0N pyrophosphate phospho-hydrolase GQF42_RS24710 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GQF42_RS24715 ENOG4108UGV hypoxanthine phosphoribosyltransferase GQF42_RS24725 ENOG4105EUJ GTP cyclohydrolase i GQF42_RS24735 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GQF42_RS24755 ENOG4105CRK lysyL-tRNA synthetase GQF42_RS24780 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS24795 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS24820 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GQF42_RS24825 ENOG4108IYU L-aspartate oxidase GQF42_RS24835 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GQF42_RS24875 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GQF42_RS24885 ENOG4105E4C Lytic transglycosylase catalytic GQF42_RS24890 ENOG4108IG5 Transcriptional regulator GQF42_RS24905 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GQF42_RS24920 ENOG4108FKE two-component system sensor kinase GQF42_RS24925 ENOG4108PYU two-component system response regulator GQF42_RS24930 ENOG41075QH Lipoprotein CseA GQF42_RS24935 ENOG4105NAF rna polymerase sigma factor GQF42_RS24950 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GQF42_RS24965 ENOG4108JWX GQF42_RS24970 ENOG4107R33 ppx gppa phosphatase GQF42_RS24975 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GQF42_RS24985 ENOG4105C01 Dihydroxy-acid dehydratase GQF42_RS24990 ENOG4108762 serine threonine protein kinase GQF42_RS24995 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein GQF42_RS25010 ENOG4105CJ1 ABC, transporter GQF42_RS25020 ENOG4105II7 pyrroline-5-carboxylate reductase GQF42_RS25050 ENOG4106UW1 Major Facilitator superfamily GQF42_RS25055 ENOG4105DGU Histone deacetylase GQF42_RS25060 ENOG4108XFF GQF42_RS25095 ENOG4108RXW HAD-superfamily subfamily IB hydrolase GQF42_RS25105 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GQF42_RS25110 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GQF42_RS25115 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GQF42_RS25120 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GQF42_RS25135 ENOG4105D52 delta-aminolevulinic acid dehydratase GQF42_RS25190 ENOG4105C75 arginyL-tRNA synthetase GQF42_RS25195 ENOG4105DK7 lysyl-tRNA synthetase GQF42_RS25215 ENOG4105E0Y RtcB Protein GQF42_RS25225 ENOG4105KK4 UPF0060 membrane protein GQF42_RS25230 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GQF42_RS25235 ENOG4108UZX fmn reductase GQF42_RS25240 ENOG4105ETX regulatoR GQF42_RS25245 ENOG41062D9 Histidine kinase GQF42_RS25255 ENOG4105CRK lysyL-tRNA synthetase GQF42_RS25265 ENOG4105DZ6 Band 7 protein GQF42_RS25275 ENOG4107TB5 TRANSCRIPTIONal GQF42_RS25290 ENOG4105VUN Transcriptional regulator GQF42_RS25310 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GQF42_RS25315 ENOG4108RH7 phosphoglycerate mutase GQF42_RS25325 ENOG4107ZT5 Thiol disulfide interchange protein GQF42_RS25330 ENOG4107QIV Cytochrome c biogenesis protein GQF42_RS25335 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) GQF42_RS25340 ENOG4105CRE cytochrome C GQF42_RS25400 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GQF42_RS25405 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GQF42_RS25410 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GQF42_RS25415 ENOG4105EW9 transcriptional regulator AsnC family GQF42_RS25420 ENOG4105DVY radical SAM domain protein GQF42_RS25435 ENOG4108R86 Transcriptional regulator GQF42_RS25455 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GQF42_RS25470 ENOG4108IMY Transcriptional regulator GQF42_RS25475 ENOG4105VEQ Cold shock protein GQF42_RS25480 ENOG4105EV6 Pfam:DUF178 GQF42_RS25485 ENOG4106A3R peptidase GQF42_RS25490 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GQF42_RS25500 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GQF42_RS25510 ENOG4105KNA -acetyltransferase GQF42_RS25520 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GQF42_RS25535 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25540 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GQF42_RS25545 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25555 ENOG4107QIZ NADH dehydrogenase GQF42_RS25560 ENOG4108IEH NADH dehydrogenase subunit g GQF42_RS25565 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GQF42_RS25570 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25575 ENOG41087XN oxidoreductase GQF42_RS25580 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25585 ENOG4105D65 subunit l GQF42_RS25595 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25600 ENOG4105C9U ATP-dependent DNA helicase RecQ GQF42_RS25605 ENOG4108IYU L-aspartate oxidase GQF42_RS25630 ENOG4105FDP GntR family transcriptional regulator GQF42_RS25655 ENOG410667J hydrolase GQF42_RS25660 ENOG4108FKH Transglycosylase SLT domain GQF42_RS25705 ENOG4105ECR NmrA family GQF42_RS25710 ENOG4105KVH Transcriptional regulator GQF42_RS25715 ENOG4105DQU oxidoreductase, subunit beta GQF42_RS25720 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GQF42_RS25740 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GQF42_RS25745 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25750 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25755 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GQF42_RS25760 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25765 ENOG4107YX3 NADH dehydrogenase subunit j GQF42_RS25770 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25785 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GQF42_RS25790 ENOG4105D0M Protease HtpX homolog GQF42_RS25805 ENOG4107SM8 Adenylate Guanylate cyclase GQF42_RS25825 ENOG4105Y3U Transglycosylase-associated protein GQF42_RS25830 ENOG4108VPT UPF0234 protein GQF42_RS25890 ENOG4105WDJ 50S ribosomal protein L33 GQF42_RS25895 ENOG410900P UPF0336 protein GQF42_RS25915 ENOG4107R4N Cell wall formation (By similarity) GQF42_RS25935 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GQF42_RS25955 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GQF42_RS25960 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GQF42_RS25965 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GQF42_RS25985 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GQF42_RS25990 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GQF42_RS26005 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GQF42_RS26010 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GQF42_RS26015 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GQF42_RS26020 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GQF42_RS26065 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GQF42_RS26070 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GQF42_RS26075 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GQF42_RS26080 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GQF42_RS26085 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GQF42_RS26090 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GQF42_RS26095 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GQF42_RS26100 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GQF42_RS26105 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GQF42_RS26110 ENOG41082SA 50s ribosomal protein l29 GQF42_RS26115 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GQF42_RS26120 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GQF42_RS26125 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GQF42_RS26130 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GQF42_RS26135 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GQF42_RS26145 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GQF42_RS26150 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GQF42_RS26155 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GQF42_RS26160 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GQF42_RS26165 ENOG410849U 50S ribosomal protein L30 GQF42_RS26170 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GQF42_RS26180 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GQF42_RS26190 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GQF42_RS26195 ENOG41067V7 50S ribosomal protein L36 GQF42_RS26200 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GQF42_RS26205 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GQF42_RS26210 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GQF42_RS26215 ENOG4108ZT0 50S ribosomal protein l17 GQF42_RS26220 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GQF42_RS26230 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GQF42_RS26235 ENOG4108UJD 30S ribosomal protein S9 GQF42_RS26240 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GQF42_RS26250 ENOG4105CS9 pantothenic acid kinase GQF42_RS26255 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GQF42_RS26265 ENOG4105CHR reductase GQF42_RS26285 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GQF42_RS26290 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GQF42_RS26295 ENOG4108097 ATP-binding protein GQF42_RS26320 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GQF42_RS26340 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS26355 ENOG4105CHP RNA polymerase GQF42_RS26380 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GQF42_RS26390 ENOG4105EMU Dehydrogenase GQF42_RS26400 ENOG4105DND Transcriptional regulator GQF42_RS26405 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GQF42_RS26410 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS26415 ENOG4108MMM RNA Polymerase GQF42_RS26425 ENOG4107QVP Dehydrogenase GQF42_RS26430 ENOG4105F9F transposase GQF42_RS26440 ENOG4107QQG Dehydrogenase GQF42_RS26445 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GQF42_RS26455 ENOG4105D9P serine threonine protein kinase GQF42_RS26465 ENOG4108DT4 serine threonine protein kinase GQF42_RS26475 ENOG4107U32 Beta-lactamase domain protein GQF42_RS26480 ENOG4108UGD Serine Threonine protein kinase GQF42_RS26485 ENOG4105C26 Dehydrogenase GQF42_RS26500 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GQF42_RS26550 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS26600 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GQF42_RS26605 ENOG4105RD5 GQF42_RS26610 ENOG4105DEG Vwa containing coxe family protein GQF42_RS26625 ENOG4105CMV Succinyl-CoA synthetase subunit beta GQF42_RS26655 ENOG4105DC1 bifunctional purine biosynthesis protein purh GQF42_RS26665 ENOG4105D9P serine threonine protein kinase GQF42_RS26680 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GQF42_RS26695 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GQF42_RS26700 ENOG4105C57 major facilitator superfamily GQF42_RS26715 ENOG4105C26 Dehydrogenase GQF42_RS26725 ENOG4108IJ7 Glycine betaine GQF42_RS26730 ENOG4108HQS Glycine betaine GQF42_RS26740 ENOG4105CR4 methylisocitrate lyase GQF42_RS26745 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GQF42_RS26750 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GQF42_RS26755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GQF42_RS26770 ENOG4106032 Glutathionylspermidine synthase GQF42_RS26775 ENOG4105C8Y Acetylornithine aminotransferase GQF42_RS26780 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GQF42_RS26785 ENOG4105C31 Tryptophanyl-tRNA synthetase GQF42_RS26805 ENOG4107H3J ribonuclease GQF42_RS26840 ENOG4108J01 L-aspartate oxidase GQF42_RS26860 ENOG4105E2D ec 3.2.1.52 GQF42_RS26885 ENOG4108MMM RNA Polymerase GQF42_RS26910 ENOG4108NIW Leucine export protein LeuE GQF42_RS26915 ENOG4107SCK Monooxygenase GQF42_RS26935 ENOG4105K64 Glycosyl transferase, family 2 GQF42_RS26945 ENOG4105F0R Cytidylyltransferase GQF42_RS26950 ENOG4105D2T synthase GQF42_RS26985 ENOG4107RM1 amidohydrolase GQF42_RS26990 ENOG4105DIH basic membrane GQF42_RS26995 ENOG4108JQ9 ABC transporter GQF42_RS27000 ENOG4105UIB (ABC) transporter GQF42_RS27035 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GQF42_RS27040 ENOG4105D94 Major Facilitator Superfamily GQF42_RS27045 ENOG4107RSM transcriptional regulator GQF42_RS27055 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GQF42_RS27085 ENOG4108KXV response regulator GQF42_RS27090 ENOG4105NAF rna polymerase sigma factor GQF42_RS27105 ENOG4105C26 Dehydrogenase GQF42_RS27110 ENOG4105C26 Dehydrogenase GQF42_RS27125 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GQF42_RS27155 ENOG4108JIK carboxylase GQF42_RS27165 ENOG4107WR6 Maf-like protein GQF42_RS27175 ENOG4105D8K carboxyl transferase GQF42_RS27190 ENOG4108QER Adenylate cyclase GQF42_RS27200 ENOG4105E39 Enoyl-CoA hydratase GQF42_RS27205 ENOG4105KDM Diguanylate cyclase with gaf sensor GQF42_RS27210 ENOG4105C84 Histidine ammonia-lyase GQF42_RS27240 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GQF42_RS27255 ENOG4105DQ4 alcohol dehydrogenase GQF42_RS27275 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GQF42_RS27320 ENOG4105NAF rna polymerase sigma factor GQF42_RS27325 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GQF42_RS27330 ENOG4105C7B Threonine dehydratase GQF42_RS27350 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GQF42_RS27360 ENOG4105T1M mycothiol conjugate amidase mca GQF42_RS27385 ENOG4105C7Z Conserved Protein GQF42_RS27400 ENOG4105CND Glycosyl transferase, family 2 GQF42_RS27420 ENOG4105C57 major facilitator superfamily GQF42_RS27430 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) GQF42_RS27450 ENOG4105CHM Aminotransferase GQF42_RS27480 ENOG4105D7K pfkb domain protein GQF42_RS27485 ENOG4108FUF Transcriptional regulator, IclR family GQF42_RS27490 ENOG4105KME endoribonuclease L-psp GQF42_RS27495 ENOG4105C6Z Gluconate GQF42_RS27580 ENOG4107QKZ Ompa motb domain protein GQF42_RS27600 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GQF42_RS27605 ENOG4108IAB Phoh family GQF42_RS27610 ENOG4106770 Is able to cleave peptidoglycan (By similarity) GQF42_RS27620 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GQF42_RS27625 ENOG4105D3R alkyl hydroperoxide reductase GQF42_RS27640 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GQF42_RS27650 ENOG4105BZ4 penicillin-binding protein GQF42_RS27665 ENOG4105C9Q fumarate hydratase class II GQF42_RS27695 ENOG4107GFK fumarate GQF42_RS27720 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GQF42_RS27725 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GQF42_RS27730 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GQF42_RS27740 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GQF42_RS27755 ENOG4105C3G gtp-binding protein GQF42_RS27785 ENOG4105EYF MMPL domain protein GQF42_RS27805 ENOG4105C6T cysteine synthase GQF42_RS27825 ENOG4105C0W non-ribosomal peptide synthetase GQF42_RS27865 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GQF42_RS27920 ENOG4105CHR reductase GQF42_RS27925 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GQF42_RS27930 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS28025 ENOG4105E33 succinate dehydrogenase GQF42_RS28050 ENOG4105CI3 gtp-binding protein typa GQF42_RS28060 ENOG4108J59 Extracellular solute-binding protein, family 5 GQF42_RS28065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GQF42_RS28070 ENOG4105C3U ABC transporter GQF42_RS28075 ENOG4108JQ7 (ABC) transporter GQF42_RS28080 ENOG4108KPJ rna polymerase sigma factor GQF42_RS28095 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GQF42_RS28100 ENOG4108JQ7 (ABC) transporter GQF42_RS28115 ENOG4108J59 Extracellular solute-binding protein, family 5 GQF42_RS28120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GQF42_RS28125 ENOG4108J59 Extracellular solute-binding protein, family 5 GQF42_RS28130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GQF42_RS28135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GQF42_RS28145 ENOG4108JQ7 (ABC) transporter GQF42_RS28175 ENOG4108M15 ABC transporter GQF42_RS28185 ENOG4108ZGX Histidine kinase GQF42_RS28190 ENOG4108S01 response regulator GQF42_RS28205 ENOG4108Z4U Ferredoxin GQF42_RS28225 ENOG4107R4C succinyl-diaminopimelate desuccinylase GQF42_RS28230 ENOG4108URH decarboxylase GQF42_RS28235 ENOG4105EEI dihydropteroate synthase GQF42_RS28245 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GQF42_RS28250 ENOG4105CGU Enoyl-CoA hydratase GQF42_RS28270 ENOG4105DU6 RNA polymerase GQF42_RS28280 ENOG4105C0H protease GQF42_RS28285 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GQF42_RS28320 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GQF42_RS28330 ENOG4105D7N magnesium and cobalt transport protein CorA GQF42_RS28340 ENOG4105DXB Major Facilitator superfamily GQF42_RS28355 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GQF42_RS28380 ENOG4105C1J atp-dependent rna helicase GQF42_RS28420 ENOG4105DEF Extracellular solute-binding protein, family 5 GQF42_RS28425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GQF42_RS28485 ENOG4105C4R Atp-dependent dna helicase GQF42_RS28490 ENOG4107QSE Dipeptidase GQF42_RS28515 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GQF42_RS28580 ENOG41063PX domain protein GQF42_RS28590 ENOG4105DJZ UPF0182 protein GQF42_RS28625 ENOG4107TK4 histidinol-phosphate phosphatase GQF42_RS28635 ENOG4105KPY Small multidrug resistance protein GQF42_RS28640 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GQF42_RS28645 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GQF42_RS28655 ENOG4108RAV Conserved protein GQF42_RS28665 ENOG4105EMN RNA polymerase sigma factor GQF42_RS28670 ENOG4105WMN AntiSigma factor GQF42_RS28675 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GQF42_RS28690 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GQF42_RS28700 ENOG41068W2 Cytochrome p-450 GQF42_RS28705 ENOG4105ECQ AraC Family Transcriptional Regulator GQF42_RS28715 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GQF42_RS28720 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GQF42_RS28735 ENOG4105FDP GntR family transcriptional regulator GQF42_RS28740 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GQF42_RS28745 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GQF42_RS28750 ENOG4108IND Tetr family transcriptional regulator GQF42_RS28765 ENOG4105CBD Diacylglycerol kinase GQF42_RS28780 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GQF42_RS28795 ENOG4105K6H D-cysteine desulfhydrase GQF42_RS28805 ENOG4105ESN nucleotide-binding protein GQF42_RS28875 ENOG4108VEQ Superoxide dismutase GQF42_RS28890 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GQF42_RS28895 ENOG4105CDA abc transporter atp-binding protein GQF42_RS28910 ENOG4105C6K Malic enzyme GQF42_RS28915 ENOG4105CB2 alcohol dehydrogenase GQF42_RS28945 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GQF42_RS28970 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GQF42_RS28975 ENOG4105EB3 Histidine kinase GQF42_RS28980 ENOG4108PYU two-component system response regulator GQF42_RS28995 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GQF42_RS29055 ENOG4105ZXU NLP P60 protein GQF42_RS29065 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GQF42_RS29070 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GQF42_RS29090 ENOG4105CJN penicillin-binding protein GQF42_RS29095 ENOG4107QHZ cell cycle protein GQF42_RS29105 ENOG4108FKE two-component system sensor kinase GQF42_RS29125 ENOG4105DQE DNA ligase GQF42_RS29130 ENOG4105FDF Could be involved in DNA repair (By similarity) GQF42_RS29140 ENOG4105YVS arsR family transcriptional regulator GQF42_RS29170 ENOG4108KWP DNA-binding transcriptional regulator GlcC GQF42_RS29210 ENOG4105CNU cell division protein FtsK GQF42_RS29270 ENOG4105ETX regulatoR GQF42_RS29275 ENOG4105C75 arginyL-tRNA synthetase GQF42_RS29280 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GQF42_RS29285 ENOG4105D6E homoserine dehydrogenase GQF42_RS29290 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GQF42_RS29295 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GQF42_RS29310 ENOG4105VFB Binds the 23S rRNA (By similarity) GQF42_RS29315 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GQF42_RS29320 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GQF42_RS29330 ENOG4107ZF2 Phosphatase GQF42_RS29340 ENOG4105ESV Glycosyl transferase, family 4 GQF42_RS29345 ENOG4105Z3P ATP synthase GQF42_RS29355 ENOG4105ZA1 atp synthase GQF42_RS29360 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GQF42_RS29365 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GQF42_RS29370 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GQF42_RS29375 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GQF42_RS29380 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GQF42_RS29385 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GQF42_RS29400 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS29405 ENOG4105BZU Histidine kinase GQF42_RS29410 ENOG4105IIP Membrane GQF42_RS29480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GQF42_RS29495 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GQF42_RS29505 ENOG4108M8W Monooxygenase GQF42_RS29550 ENOG4105CHU acetyl-coa acetyltransferase GQF42_RS29615 ENOG4105D5P Methylmalonyl-coA mutase GQF42_RS29650 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GQF42_RS29655 ENOG4105C6K Malic enzyme GQF42_RS29660 ENOG4105CTQ phosphohexokinase GQF42_RS29670 ENOG4105I1K ABC transporter GQF42_RS29675 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GQF42_RS29685 ENOG4108MRH transcriptional regulatory protein GQF42_RS29690 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GQF42_RS29695 ENOG4107QJT sodium dicarboxylate symporter GQF42_RS29705 ENOG4105C57 major facilitator superfamily GQF42_RS29730 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GQF42_RS29735 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GQF42_RS29745 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GQF42_RS29750 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GQF42_RS29790 ENOG4105BZ1 (ABC) transporter GQF42_RS29795 ENOG4105BZ1 (ABC) transporter GQF42_RS29800 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS29805 ENOG4105BZU Histidine kinase GQF42_RS29815 ENOG4105CJ1 ABC, transporter GQF42_RS29820 ENOG4105BZ1 (ABC) transporter GQF42_RS29825 ENOG4105BZ1 (ABC) transporter GQF42_RS29890 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) GQF42_RS29935 ENOG4105EJQ L-serine dehydratase GQF42_RS29940 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GQF42_RS29945 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GQF42_RS29950 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GQF42_RS29970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GQF42_RS29975 ENOG4108J59 Extracellular solute-binding protein, family 5 GQF42_RS29990 ENOG4108JQ7 (ABC) transporter GQF42_RS29995 ENOG4105CAQ asparagine synthetase GQF42_RS30010 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GQF42_RS30020 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GQF42_RS30030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GQF42_RS30040 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GQF42_RS30045 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GQF42_RS30075 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GQF42_RS30080 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GQF42_RS30085 ENOG4105CIK Amidinotransferase GQF42_RS30100 ENOG4105EN6 Membrane GQF42_RS30130 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GQF42_RS30145 ENOG4108URH decarboxylase GQF42_RS30150 ENOG4105EMU Dehydrogenase GQF42_RS30160 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GQF42_RS30165 ENOG4105BZU Histidine kinase GQF42_RS30185 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GQF42_RS30190 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GQF42_RS30200 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GQF42_RS30210 ENOG4105EYF MMPL domain protein GQF42_RS30215 ENOG4105D9U N-acetyltransferase GQF42_RS30230 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS30245 ENOG4105CPC Aldo Keto reductase GQF42_RS30270 ENOG4108ZP8 Acetolactate synthase small subunit GQF42_RS30275 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GQF42_RS30280 ENOG4108JQ1 Dehydrogenase GQF42_RS30285 ENOG4105C57 major facilitator superfamily GQF42_RS30305 ENOG4107YHD transcriptional regulator GQF42_RS30315 ENOG4105C26 Dehydrogenase GQF42_RS30325 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GQF42_RS30330 ENOG41080UQ Transcriptional regulator GQF42_RS30340 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GQF42_RS30345 ENOG4105CM2 brancheD-chain amino acid aminotransferase GQF42_RS30360 ENOG4105CQM Urea amidohydrolase subunit alpha GQF42_RS30365 ENOG4105DWY Agmatine deiminase GQF42_RS30380 ENOG4105CSH Transporter GQF42_RS30385 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GQF42_RS30415 ENOG4108YYC ycei family GQF42_RS30420 ENOG4106AM8 polysaccharide lyase family 8 GQF42_RS30425 ENOG4105D8K carboxyl transferase GQF42_RS30445 ENOG4105GWZ Roadblock lc7 family protein GQF42_RS30465 ENOG4105GWZ Roadblock lc7 family protein GQF42_RS30480 ENOG4105ERH Fumarylacetoacetate hydrolase GQF42_RS30485 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GQF42_RS30530 ENOG41069M3 Transcriptional regulator GQF42_RS30535 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GQF42_RS30540 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GQF42_RS30550 ENOG4105K70 DNA-binding protein GQF42_RS30560 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) GQF42_RS30570 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GQF42_RS30575 ENOG4105CPF Cell wall formation (By similarity) GQF42_RS30595 ENOG4105DWF phosphomethylpyrimidine kinase GQF42_RS30600 ENOG4105VB9 50S ribosomal protein l28 GQF42_RS30605 ENOG4105DP4 dak2 domain fusion protein ylov GQF42_RS30615 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GQF42_RS30625 ENOG4106H78 methyltransferase GQF42_RS30630 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GQF42_RS30645 ENOG41084BZ 50S ribosomal protein L32 GQF42_RS30650 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GQF42_RS30655 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GQF42_RS30660 ENOG4105KVH Transcriptional regulator GQF42_RS30665 ENOG4105CS1 NAD(P)H quinone oxidoreductase GQF42_RS30675 ENOG4105K4I Scp-like extracellular GQF42_RS30680 ENOG4108375 Acylphosphatase (EC 3.6.1.7) GQF42_RS30695 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GQF42_RS30745 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GQF42_RS30755 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GQF42_RS30770 ENOG4105K5M 30s ribosomal protein S16 GQF42_RS30775 ENOG41082KU UPF0109 protein GQF42_RS30780 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GQF42_RS30785 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GQF42_RS30790 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GQF42_RS30800 ENOG4107QYR Signal peptidase i GQF42_RS30810 ENOG4107QYR Signal peptidase i GQF42_RS30815 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GQF42_RS30825 ENOG41080R2 UPF0102 protein GQF42_RS30830 ENOG4105C0P Mg chelatase subunit ChlI GQF42_RS30840 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GQF42_RS30855 ENOG4105CE9 30S ribosomal protein S2 GQF42_RS30860 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GQF42_RS30865 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GQF42_RS30870 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GQF42_RS30875 ENOG4105KNE Phosphatidate cytidylyltransferase GQF42_RS30880 ENOG4108YYC ycei family GQF42_RS30885 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GQF42_RS30895 ENOG4105ECW sulfate abc transporter GQF42_RS30900 ENOG4108UCS ABC, transporter GQF42_RS30925 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GQF42_RS30930 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GQF42_RS30940 ENOG4105C26 Dehydrogenase GQF42_RS30955 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GQF42_RS30960 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GQF42_RS30990 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GQF42_RS30995 ENOG4105F38 ABC transporter, permease GQF42_RS31000 ENOG4105D38 putrescine abc transporter GQF42_RS31005 ENOG4105CJP fad dependent oxidoreductase GQF42_RS31035 ENOG4105G9B Transcriptional regulator GQF42_RS31035 ENOG4105G9B Transcriptional regulator GQF42_RS31075 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GQF42_RS31080 ENOG4105DZP Membrane-associated zinc metalloprotease GQF42_RS31085 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GQF42_RS31115 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GQF42_RS31120 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase GQF42_RS31135 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GQF42_RS31150 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GQF42_RS31160 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GQF42_RS31165 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GQF42_RS31200 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GQF42_RS31265 ENOG4108762 serine threonine protein kinase GQF42_RS31290 ENOG4105EC2 ftsk spoIIIe GQF42_RS31305 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GQF42_RS31310 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GQF42_RS31315 ENOG4105C1V Peptidase, M16 GQF42_RS31320 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GQF42_RS31340 ENOG4107V6K Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) GQF42_RS31345 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GQF42_RS31350 ENOG4105CN5 Metallo-Beta-Lactamase GQF42_RS31370 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GQF42_RS31395 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GQF42_RS31410 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GQF42_RS31420 ENOG4105CEV competence damage-inducible protein GQF42_RS31425 ENOG4105WBV Transcriptional regulator GQF42_RS31430 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GQF42_RS31445 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GQF42_RS31450 ENOG4107QRT dEAD DEAH box helicase GQF42_RS31465 ENOG4105DSF transport protein GQF42_RS31480 ENOG4105EAH synthase GQF42_RS31490 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GQF42_RS31505 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GQF42_RS31520 ENOG4105DRP amino acid AbC transporter GQF42_RS31525 ENOG4108Q1T ABC transporter GQF42_RS31530 ENOG4107UBR Extracellular solute-binding protein family 3 GQF42_RS31535 ENOG4105CDA abc transporter atp-binding protein GQF42_RS31540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GQF42_RS31545 ENOG4105EB3 Histidine kinase GQF42_RS31595 ENOG4105KZK Tautomerase pptA GQF42_RS31605 ENOG4105F27 Major Facilitator GQF42_RS31615 ENOG4105F27 Major Facilitator GQF42_RS31620 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GQF42_RS31635 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GQF42_RS31655 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GQF42_RS31665 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GQF42_RS31670 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GQF42_RS31680 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GQF42_RS31735 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GQF42_RS31740 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GQF42_RS31745 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GQF42_RS31760 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GQF42_RS31780 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GQF42_RS31795 ENOG4105C9U ATP-dependent DNA helicase RecQ GQF42_RS31820 ENOG4105DRR Transcriptional regulator, GntR family GQF42_RS31825 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GQF42_RS31840 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GQF42_RS31855 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS31865 ENOG4107QN1 sodium solute GQF42_RS31870 ENOG4108MRH transcriptional regulatory protein GQF42_RS31880 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GQF42_RS31890 ENOG4108MRH transcriptional regulatory protein GQF42_RS31905 ENOG4105BZN citrate synthase GQF42_RS31910 ENOG4105BZN citrate synthase GQF42_RS31915 ENOG4105CKI cobalamin synthesis protein GQF42_RS31920 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GQF42_RS31940 ENOG4105DRR Transcriptional regulator, GntR family GQF42_RS31945 ENOG410849S phosphocarrier protein (HPr) GQF42_RS31955 ENOG4105CD5 CoA-binding domain protein GQF42_RS31970 ENOG4107W53 thymidine kinase GQF42_RS31980 ENOG4105KHC sulfurtransferase GQF42_RS32005 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GQF42_RS32015 ENOG4105F44 Two component transcriptional regulator, winged helix family GQF42_RS32020 ENOG4106F60 Histidine kinase GQF42_RS32045 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GQF42_RS32080 ENOG4107VEG TrkA-N domain protein GQF42_RS32085 ENOG4105C0X amino acid GQF42_RS32090 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GQF42_RS32115 ENOG4105VEQ Cold shock protein GQF42_RS32120 ENOG4105C1J atp-dependent rna helicase GQF42_RS32135 ENOG4108XEP Alpha Beta Hydrolase Fold protein GQF42_RS32155 ENOG4108UT2 hemolysin iii GQF42_RS32195 ENOG4105CN5 Metallo-Beta-Lactamase GQF42_RS32205 ENOG4105CPQ Dehydrogenase GQF42_RS32215 ENOG4107TTQ Alpha beta hydrolase fold GQF42_RS32250 ENOG4107EPK O-methyltransferase, family 2 GQF42_RS32260 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GQF42_RS32270 ENOG4105DVY radical SAM domain protein GQF42_RS32330 ENOG4106611 bacteriocin immunity GQF42_RS32360 ENOG4105CEU Arginine dihydrolase GQF42_RS32365 ENOG4105DBV ornithine carbamoyltransferase GQF42_RS32370 ENOG4105CUB amino acid GQF42_RS32380 ENOG4105CIR epoxide hydrolase GQF42_RS32390 ENOG4105CGU Enoyl-CoA hydratase GQF42_RS32435 ENOG4105FDP GntR family transcriptional regulator GQF42_RS32455 ENOG4105D17 glycoside hydrolase, family 3 domain protein GQF42_RS32470 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GQF42_RS32490 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GQF42_RS32495 ENOG4107QM5 aconitate hydratase GQF42_RS32500 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GQF42_RS32505 ENOG4105CWX Alpha-1,2-mannosidase GQF42_RS32515 ENOG4108JP0 extracellular solute-binding protein family 1 GQF42_RS32520 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GQF42_RS32525 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GQF42_RS32530 ENOG4105E2R ROK family GQF42_RS32535 ENOG4105DFW ABC transporter GQF42_RS32540 ENOG4105C2J ABC transporter GQF42_RS32545 ENOG4107RNG ABC transporter GQF42_RS32550 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GQF42_RS32555 ENOG4105CUB amino acid GQF42_RS32570 ENOG4105PNM synthesis protein GQF42_RS32605 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GQF42_RS32610 ENOG4105CHU acetyl-coa acetyltransferase GQF42_RS32615 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GQF42_RS32630 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GQF42_RS32645 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GQF42_RS32660 ENOG4107JTW chlorite dismutase GQF42_RS32680 ENOG4105E18 UPF0276 protein GQF42_RS32705 ENOG4108IUX (ABC) transporter GQF42_RS32720 ENOG4108V1U phospholipid-binding protein GQF42_RS32735 ENOG4107B2H carbonic anhydrase GQF42_RS32760 ENOG4105DFU Cell wall formation (By similarity) GQF42_RS32765 ENOG4105E0X reductase GQF42_RS32785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GQF42_RS32805 ENOG4108IJ8 ABC transporter GQF42_RS32810 ENOG4105E90 ABC transporter GQF42_RS32815 ENOG4105E90 ABC transporter GQF42_RS32820 ENOG4108HQR Glycine betaine GQF42_RS32830 ENOG41082SX arsR family transcriptional regulator GQF42_RS32850 ENOG4107SVN transposase GQF42_RS32855 ENOG410836F Transposase GQF42_RS32860 ENOG41064MX Tetr family transcriptional regulator GQF42_RS32875 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GQF42_RS32880 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein GQF42_RS32990 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GQF42_RS33010 ENOG4108IY8 ABC, transporter GQF42_RS33035 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) GQF42_RS33040 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GQF42_RS33065 ENOG4107RR1 TRANSCRIPTIONal GQF42_RS33070 ENOG4105CSU acyl-Coa dehydrogenase GQF42_RS33095 ENOG4105CR4 methylisocitrate lyase GQF42_RS33115 ENOG4105EBR Carboxylesterase GQF42_RS33120 ENOG4108J5H Homocysteine s-methyltransferase GQF42_RS33160 ENOG4105QE3 oxidoreductase GQF42_RS33180 ENOG4105C1J atp-dependent rna helicase GQF42_RS33185 ENOG4105VEQ Cold shock protein GQF42_RS33245 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GQF42_RS33280 ENOG4105C7K acetolactate synthase GQF42_RS33295 ENOG4105DRR Transcriptional regulator, GntR family GQF42_RS33330 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GQF42_RS33335 ENOG4105C7N Xanthine uracil vitamin C permease GQF42_RS33345 ENOG410829K Lysine exporter protein (Lyse ygga) GQF42_RS33355 ENOG4108ZJ4 polysaccharide deacetylase GQF42_RS33390 ENOG4105EPJ extracellular solute-binding protein family 1 GQF42_RS33395 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GQF42_RS33410 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GQF42_RS33415 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS33430 ENOG41060W2 glyoxylate carboligase GQF42_RS33440 ENOG4105CH6 catalase GQF42_RS33445 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GQF42_RS33450 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GQF42_RS33470 ENOG4105VT2 5-hydroxyisourate hydrolase GQF42_RS33480 ENOG4105C2W permease GQF42_RS33485 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GQF42_RS33490 ENOG4105C2W permease GQF42_RS33500 ENOG4107S9F NmrA family GQF42_RS33510 ENOG4105KVH Transcriptional regulator GQF42_RS33525 ENOG4108ZM9 phosphoglycerate mutase GQF42_RS33540 ENOG4105CHM Aminotransferase GQF42_RS33560 ENOG4105DUU IucA IucC family protein GQF42_RS33570 ENOG4105C31 Tryptophanyl-tRNA synthetase GQF42_RS33580 ENOG4107R9S Malate synthase GQF42_RS33585 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GQF42_RS33595 ENOG4107HP6 Transcriptional regulator GQF42_RS33640 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS33650 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GQF42_RS33655 ENOG4105FDP GntR family transcriptional regulator GQF42_RS33665 ENOG41062B0 ABC transporter, permease GQF42_RS33670 ENOG4105C2J ABC transporter GQF42_RS33675 ENOG4105DKQ ROK family GQF42_RS33685 ENOG4105C0D helicase GQF42_RS33710 ENOG4107RN3 metallophosphoesterase GQF42_RS33745 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GQF42_RS33765 ENOG4105WQI isochorismatase GQF42_RS33770 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS33780 ENOG4105EHG Permease protein GQF42_RS33785 ENOG4105E0A ABC, transporter GQF42_RS33835 ENOG4105MWK D-amino acid dehydrogenase, small subunit GQF42_RS33840 ENOG4108MWI inositol mono-phosphatase GQF42_RS33850 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GQF42_RS33875 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GQF42_RS33880 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GQF42_RS33910 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GQF42_RS33950 ENOG4106A3M Cytochrome p-450 GQF42_RS33955 ENOG4105CPQ Dehydrogenase GQF42_RS33985 ENOG4105EV4 Multidrug resistance protein mdtH GQF42_RS34150 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GQF42_RS34155 ENOG4105EPW hflc protein GQF42_RS34190 ENOG4105VBF alkaline shock protein GQF42_RS34235 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GQF42_RS34255 ENOG4105CDA abc transporter atp-binding protein GQF42_RS34260 ENOG4107UBR Extracellular solute-binding protein family 3 GQF42_RS34265 ENOG4105EAD ABC transporter GQF42_RS34270 ENOG4105DRP amino acid AbC transporter GQF42_RS34285 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GQF42_RS34290 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GQF42_RS34315 ENOG4105C8Y Acetylornithine aminotransferase GQF42_RS34330 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GQF42_RS34340 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GQF42_RS34375 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GQF42_RS34395 ENOG4105ECY inositol monophosphatase GQF42_RS34415 ENOG4105DAE Methylenetetrahydrofolate reductase GQF42_RS34430 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GQF42_RS34435 ENOG4108BAS reductase GQF42_RS34465 ENOG4105BZW Glycerate kinase GQF42_RS34475 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme GQF42_RS34485 ENOG4105C1G acyl-Coa dehydrogenase GQF42_RS34500 ENOG4105RFZ Methylmalonyl-coA mutase GQF42_RS34515 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GQF42_RS34550 ENOG4108Q50 Histidine kinase GQF42_RS34585 ENOG4105BZU Histidine kinase GQF42_RS34590 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS34605 ENOG4108ME1 Peptidase M55 D-aminopeptidase GQF42_RS34610 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GQF42_RS34620 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GQF42_RS34655 ENOG4105GCF PGAM GQF42_RS34660 ENOG4105C5H ABC transporter GQF42_RS34690 ENOG4105E8R UPF0173 metal-dependent hydrolase GQF42_RS34725 ENOG4106GCT Dehydratase GQF42_RS34735 ENOG4105CYP glycoside hydrolase, family GQF42_RS34740 ENOG41065HY 1,4-beta-cellobiosidase GQF42_RS34745 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GQF42_RS34765 ENOG4105CV8 reductase GQF42_RS34775 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) GQF42_RS34805 ENOG4105EX0 alpha-galactosidase GQF42_RS34820 ENOG4107653 Transcriptional regulator GQF42_RS34840 ENOG4108VHT MarR family transcriptional regulator GQF42_RS34845 ENOG4105D3W isochorismatase GQF42_RS34850 ENOG4105CHR reductase GQF42_RS34860 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GQF42_RS34875 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GQF42_RS34945 ENOG4105VEQ Cold shock protein GQF42_RS34955 ENOG4105DZR Type I site-specific deoxyribonuclease GQF42_RS34995 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GQF42_RS35000 ENOG4105E6M Sulphatase-modifying factor protein GQF42_RS35015 ENOG4105C7H Helicase, RecD TraA family GQF42_RS35150 ENOG4105CPQ Dehydrogenase GQF42_RS35155 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GQF42_RS35185 ENOG4105KF0 sporulation and cell division protein, SsgA GQF42_RS35250 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GQF42_RS35295 ENOG4105K4H Nlp p60 protein GQF42_RS35340 ENOG4105CEC DNA methylase N-4 N-6 GQF42_RS35345 ENOG4105D5G Transposase GQF42_RS35405 ENOG4105EKQ RNA-directed DNA polymerase GQF42_RS35415 ENOG4105D5G Transposase GQF42_RS35445 ENOG41073TP transcriptional regulator GQF42_RS35450 ENOG4108KQ5 Integrase catalytic subunit GQF42_RS35480 ENOG4105DQ6 Transposase GQF42_RS35510 ENOG4107UB2 Alpha beta hydrolase fold GQF42_RS35555 ENOG4105CJ1 ABC, transporter GQF42_RS35575 ENOG4105VEQ Cold shock protein GQF42_RS35595 ENOG4105D5G Transposase GQF42_RS35650 ENOG4107SM8 Adenylate Guanylate cyclase GQF42_RS35675 ENOG4107RA9 decarboxylase GQF42_RS35695 ENOG4105K56 Transcriptional regulator GQF42_RS35700 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GQF42_RS35715 ENOG4105DMF Dehydrogenase GQF42_RS35765 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GQF42_RS35770 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GQF42_RS35775 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GQF42_RS35825 ENOG4105CHR reductase GQF42_RS35830 ENOG4107YPT transcriptional regulator GQF42_RS35835 ENOG4105C09 Bile acid GQF42_RS35840 ENOG4105E39 Enoyl-CoA hydratase GQF42_RS35845 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GQF42_RS35850 ENOG4108FUF Transcriptional regulator, IclR family GQF42_RS35885 ENOG4107RA9 decarboxylase GQF42_RS35900 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GQF42_RS36010 ENOG4105CY3 ABC transporter, permease GQF42_RS36055 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GQF42_RS36120 ENOG4107U9T Pfam:Ribonuclease_BN GQF42_RS36135 ENOG4105CGD Nad-dependent epimerase dehydratase GQF42_RS36185 ENOG4105KVH Transcriptional regulator GQF42_RS36220 ENOG4108762 serine threonine protein kinase GQF42_RS36235 ENOG4108IXY short-chain dehydrogenase reductase GQF42_RS36250 ENOG4108ZHJ Organic hydroperoxide resistance protein GQF42_RS36300 ENOG41090B9 response to stress GQF42_RS36330 ENOG4105NAF rna polymerase sigma factor GQF42_RS36355 ENOG4107QJT sodium dicarboxylate symporter GQF42_RS36360 ENOG4105C7F AcnD-accessory protein PrpF GQF42_RS36370 ENOG4107U9B transcriptional regulator GQF42_RS36390 ENOG4108UHU Aldolase GQF42_RS36395 ENOG4105CHR reductase GQF42_RS36400 ENOG4105CPQ Dehydrogenase GQF42_RS36415 ENOG4105DIA mandelate racemase muconate lactonizing GQF42_RS36420 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GQF42_RS36425 ENOG4105C2J ABC transporter GQF42_RS36445 ENOG4105KVH Transcriptional regulator GQF42_RS36450 ENOG4107S5I aldo keto reductase GQF42_RS36475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GQF42_RS36490 ENOG4105EFZ amidohydrolase GQF42_RS36510 ENOG4105BZ4 penicillin-binding protein GQF42_RS36565 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GQF42_RS36585 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GQF42_RS36615 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS36620 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GQF42_RS36625 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GQF42_RS36635 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GQF42_RS36645 ENOG4105CAQ asparagine synthetase GQF42_RS36650 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GQF42_RS36660 ENOG4105CIK Amidinotransferase GQF42_RS36670 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GQF42_RS36680 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GQF42_RS36700 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GQF42_RS36725 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GQF42_RS36730 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GQF42_RS36735 ENOG4105CHM Aminotransferase GQF42_RS36755 ENOG4105M6F mutator MutT protein GQF42_RS36765 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GQF42_RS36770 ENOG4105CD5 CoA-binding domain protein GQF42_RS36780 ENOG4105E39 Enoyl-CoA hydratase GQF42_RS36785 ENOG4105ETS cytosine purines uracil thiamine allantoin GQF42_RS36800 ENOG41062D9 Histidine kinase GQF42_RS36805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GQF42_RS36820 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GQF42_RS36825 ENOG4105E8G Major facilitator Superfamily GQF42_RS36835 ENOG4107SJB teichoic acid biosynthesis GQF42_RS36840 ENOG4105CND Glycosyl transferase, family 2 GQF42_RS36845 ENOG4108SEA Esterase GQF42_RS36860 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GQF42_RS36865 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GQF42_RS36875 ENOG4105E2R ROK family GQF42_RS36880 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GQF42_RS36945 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GQF42_RS36955 ENOG4105CG3 alpha amylase, catalytic region GQF42_RS36970 ENOG4108RU0 short-chain dehydrogenase reductase GQF42_RS36985 ENOG4105ME7 Membrane GQF42_RS37025 ENOG4105CWX Alpha-1,2-mannosidase GQF42_RS37035 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GQF42_RS37055 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GQF42_RS37095 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GQF42_RS37115 ENOG4107QJN gtp cyclohydrolase ii GQF42_RS37135 ENOG410905P Pyridoxamine 5-phosphate GQF42_RS37155 ENOG4105CSH Transporter GQF42_RS37165 ENOG4107S9B Shikimate dehydrogenase GQF42_RS37180 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GQF42_RS37185 ENOG4108J5G 6-phosphogluconate dehydrogenase GQF42_RS37190 ENOG4107QP8 phosphohexose isomerase GQF42_RS37205 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GQF42_RS37245 ENOG4105F8D glycoside hydrolase family 4 GQF42_RS37305 ENOG4105VEQ Cold shock protein GQF42_RS37310 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GQF42_RS37350 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GQF42_RS37355 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GQF42_RS37360 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha GQF42_RS37400 ENOG4105DQE DNA ligase GQF42_RS37410 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS37420 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GQF42_RS37430 ENOG4106V2I dimethylaminohydrolase GQF42_RS37435 ENOG4105C5H ABC transporter GQF42_RS37440 ENOG4105KF0 sporulation and cell division protein, SsgA GQF42_RS37455 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GQF42_RS37465 ENOG4105EG6 Saccharopine dehydrogenase GQF42_RS37470 ENOG410846T CoA-transferase family III GQF42_RS37475 ENOG4105CHU acetyl-coa acetyltransferase GQF42_RS37480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GQF42_RS37485 ENOG4108Z6Z Transcriptional regulator GQF42_RS37500 ENOG4108U3T pfkb domain protein GQF42_RS37525 ENOG4105C5H ABC transporter GQF42_RS37535 ENOG4105BZM domain protein GQF42_RS37540 ENOG4105ECQ AraC Family Transcriptional Regulator GQF42_RS37550 ENOG4105E39 Enoyl-CoA hydratase GQF42_RS37565 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GQF42_RS37590 ENOG4108MDK Dehydrogenase GQF42_RS37610 ENOG4105EY8 ABC transporter GQF42_RS37615 ENOG4105FBD synthase GQF42_RS37625 ENOG4107S11 squalene-associated FAD-dependent desaturase GQF42_RS37635 ENOG4105EWU Squalene--hopene cyclase GQF42_RS37650 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GQF42_RS37680 ENOG4105EKQ RNA-directed DNA polymerase GQF42_RS37690 ENOG41090WU lipolytic protein G-D-S-L family GQF42_RS37735 ENOG4105CPQ Dehydrogenase GQF42_RS37740 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GQF42_RS37745 ENOG4106NZI LysR family Transcriptional regulator GQF42_RS37805 ENOG4105C5F glutamine synthetase GQF42_RS37815 ENOG4108HCJ Hydrolase GQF42_RS37825 ENOG4105E5G Alpha beta hydrolase fold GQF42_RS37830 ENOG4105CHU acetyl-coa acetyltransferase GQF42_RS37835 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS37845 ENOG4105U0R haloacid dehalogenase-like hydrolase GQF42_RS37885 ENOG4105I1K ABC transporter GQF42_RS37900 ENOG4105FDP GntR family transcriptional regulator GQF42_RS37910 ENOG4105CNN ABC, transporter GQF42_RS37915 ENOG4105C2J ABC transporter GQF42_RS37935 ENOG4105CHR reductase GQF42_RS37945 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS37970 ENOG4105C0R drug resistance transporter emrb qaca subfamily GQF42_RS37980 ENOG4105DQE DNA ligase GQF42_RS37985 ENOG4108JPZ Monovalent cation H antiporter subunit D GQF42_RS38020 ENOG4108Z0Z intracellular protease Pfpi family GQF42_RS38045 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GQF42_RS38060 ENOG4108XNA Gas vesicle GQF42_RS38065 ENOG4107ETC gas vesicle protein GQF42_RS38075 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GQF42_RS38090 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GQF42_RS38130 ENOG4105CPC Aldo Keto reductase GQF42_RS38145 ENOG4105D5Q Arginine ornithine antiporter GQF42_RS38155 ENOG4105CTU Proline racemase GQF42_RS38160 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GQF42_RS38175 ENOG4105MWK D-amino acid dehydrogenase, small subunit GQF42_RS38205 ENOG4106S2D Transcriptional regulator GQF42_RS38215 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GQF42_RS38230 ENOG4106A3M Cytochrome p-450 GQF42_RS38240 ENOG4105DWV Homoserine O-trans-acetylase GQF42_RS38250 ENOG4105E9K Isocitrate dehydrogenase GQF42_RS38255 ENOG4105D64 Mechanosensitive ion channel GQF42_RS38260 ENOG4105CUB amino acid GQF42_RS38270 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GQF42_RS38275 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GQF42_RS38285 ENOG4105E39 Enoyl-CoA hydratase GQF42_RS38295 ENOG4105BZ1 (ABC) transporter GQF42_RS38300 ENOG4106UDK Cellulose-binding, family II GQF42_RS38305 ENOG4105EGE secreted protein GQF42_RS38315 ENOG4108NEV two component transcriptional regulator, LytTR family GQF42_RS38330 ENOG4108HRK Histidine kinase GQF42_RS38380 ENOG4105CK7 Sodium proline symporter GQF42_RS38395 ENOG4105E2A Dehydrogenase GQF42_RS38420 ENOG4107RSM transcriptional regulator GQF42_RS38425 ENOG4107VHA regulatoR GQF42_RS38430 ENOG4105CFG Acts as a chaperone (By similarity) GQF42_RS38435 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GQF42_RS38440 ENOG4105DVC DnaJ domain protein GQF42_RS38450 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GQF42_RS38470 ENOG4105F9F transposase GQF42_RS38475 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GQF42_RS38485 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GQF42_RS38505 ENOG4107QPH glycogen) synthase GQF42_RS38510 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GQF42_RS38515 ENOG4105C7W Xanthine dehydrogenase GQF42_RS38530 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GQF42_RS38545 ENOG4105E6M Sulphatase-modifying factor protein GQF42_RS38555 ENOG4105CWX Alpha-1,2-mannosidase GQF42_RS38570 ENOG4105CHR reductase GQF42_RS38600 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS38635 ENOG41073TP transcriptional regulator GQF42_RS38640 ENOG4105DFW ABC transporter GQF42_RS38645 ENOG4105C2J ABC transporter GQF42_RS38655 ENOG4105DIA mandelate racemase muconate lactonizing GQF42_RS38660 ENOG4105CHR reductase GQF42_RS38720 ENOG4105CUB amino acid GQF42_RS38735 ENOG4105CRK lysyL-tRNA synthetase GQF42_RS38740 ENOG4108ZJ4 polysaccharide deacetylase GQF42_RS38775 ENOG4105BZU Histidine kinase GQF42_RS38795 ENOG4105E33 succinate dehydrogenase GQF42_RS38840 ENOG4105DEN Luciferase family GQF42_RS38850 ENOG4105WKW Pfam:DUF1458 GQF42_RS38860 ENOG41067HS methyltransferase GQF42_RS38865 ENOG4108V75 Glutamine amidotransferase GQF42_RS38870 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process GQF42_RS38875 ENOG4105D1K glutamate--cysteine ligase GQF42_RS38905 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GQF42_RS38915 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS38920 ENOG41080RH Thioredoxin GQF42_RS38930 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GQF42_RS38955 ENOG4105CQB FAD linked oxidase domain protein GQF42_RS38960 ENOG4108UKZ OsmC family GQF42_RS38980 ENOG4105EUB pirin domain protein GQF42_RS38985 ENOG4107UWP Major facilitator superfamily MFS_1 GQF42_RS39000 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GQF42_RS39010 ENOG4105E90 ABC transporter GQF42_RS39015 ENOG4105E90 ABC transporter GQF42_RS39025 ENOG4108IJ8 ABC transporter GQF42_RS39030 ENOG41080R8 Conserved Protein GQF42_RS39040 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GQF42_RS39045 ENOG4105DET Rhamnulokinase GQF42_RS39055 ENOG4105C9F isomerase GQF42_RS39060 ENOG4105C2J ABC transporter GQF42_RS39065 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GQF42_RS39070 ENOG4105F5R ABC transporter GQF42_RS39075 ENOG4105D4B ABC, transporter GQF42_RS39080 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) GQF42_RS39085 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS39095 ENOG4105DDN Pentapeptide repeat-containing protein GQF42_RS39100 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GQF42_RS39105 ENOG4108R86 Transcriptional regulator GQF42_RS39115 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GQF42_RS39145 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GQF42_RS39165 ENOG4105DCG PHP domain protein GQF42_RS39180 ENOG4105EDW glycosyl transferase, family 39 GQF42_RS39185 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GQF42_RS39205 ENOG4105ECQ AraC Family Transcriptional Regulator GQF42_RS39215 ENOG4105CUB amino acid GQF42_RS39240 ENOG4106YKD Cytochrome p-450 GQF42_RS39275 ENOG4105CPC Aldo Keto reductase GQF42_RS39315 ENOG4108V5V Serine Threonine protein kinase GQF42_RS39320 ENOG4105DU6 RNA polymerase GQF42_RS39330 ENOG4105CNT hydrolase family 2 GQF42_RS39360 ENOG4105DMF Dehydrogenase GQF42_RS39390 ENOG4108JJA ABC, transporter GQF42_RS39395 ENOG4108JJA ABC, transporter GQF42_RS39445 ENOG4105CJA serine threonine protein kinase GQF42_RS39460 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GQF42_RS39470 ENOG4105BZ9 Cytochrome C oxidase, subunit I GQF42_RS39485 ENOG41080V3 Major Facilitator superfamily GQF42_RS39500 ENOG4105XRQ Xanthine dehydrogenase accessory factor GQF42_RS39535 ENOG4107EMZ glycosyl transferase family GQF42_RS39540 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GQF42_RS39565 ENOG4105C5X domain protein GQF42_RS39575 ENOG4105CHR reductase GQF42_RS39580 ENOG4108R85 Short chain dehydrogenase GQF42_RS39585 ENOG4105DND Transcriptional regulator GQF42_RS39605 ENOG4105E2R ROK family GQF42_RS39625 ENOG4105C87 Aminotransferase class I and II GQF42_RS39645 ENOG41067SE Tetr family transcriptional regulator GQF42_RS39650 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS39660 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GQF42_RS39665 ENOG4105DRS transport system, permease GQF42_RS39670 ENOG4105C5I Dehydrogenase GQF42_RS39745 ENOG4105GR3 Histidine kinase GQF42_RS39750 ENOG4105ETX regulatoR GQF42_RS39755 ENOG410841Q phosphoesterase PA-phosphatase related protein GQF42_RS39765 ENOG4105DQR SNARE associated Golgi GQF42_RS39775 ENOG4105DBE peroxidase GQF42_RS39780 ENOG4105D9G High-affinity GQF42_RS39795 ENOG4105BZP glycoside hydrolase 15-related GQF42_RS39800 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GQF42_RS39815 ENOG4108N5B 2-phosphosulfolactate phosphatase GQF42_RS39870 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GQF42_RS39895 ENOG4105C0A alcohol dehydrogenase GQF42_RS39905 ENOG4105C26 Dehydrogenase GQF42_RS39910 ENOG4105DTQ mandelate racemase muconate lactonizing GQF42_RS39915 ENOG4108P4C Formaldehyde-activating enzyme GQF42_RS39930 ENOG4105C54 Major Facilitator superfamily GQF42_RS39935 ENOG4107SET aldo keto reductase GQF42_RS39945 ENOG4106A3M Cytochrome p-450 GQF42_RS39975 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GQF42_RS39995 ENOG4106UDK Cellulose-binding, family II GQF42_RS40040 ENOG4105ERR inositol mono-phosphatase GQF42_RS40050 ENOG4105EGE secreted protein GQF42_RS40090 ENOG4108ZGX Histidine kinase GQF42_RS40095 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS40105 ENOG4108KB2 LysR family Transcriptional regulator GQF42_RS40115 ENOG4108KPJ rna polymerase sigma factor GQF42_RS40135 ENOG4105CPN adenine deaminase GQF42_RS40140 ENOG4105CUB amino acid GQF42_RS40175 ENOG4105DBE peroxidase GQF42_RS40185 ENOG4108ZJ4 polysaccharide deacetylase GQF42_RS40235 ENOG4105CWX Alpha-1,2-mannosidase GQF42_RS40245 ENOG4107QTZ amino acid GQF42_RS40280 ENOG4105CHR reductase GQF42_RS40310 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GQF42_RS40315 ENOG4105EUB pirin domain protein GQF42_RS40320 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GQF42_RS40335 ENOG4108IG5 Transcriptional regulator GQF42_RS40360 ENOG4108NNZ chitinase GQF42_RS40365 ENOG4107SVN transposase GQF42_RS40370 ENOG410836F Transposase GQF42_RS40385 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GQF42_RS40390 ENOG4105D81 ABC transporter, permease GQF42_RS40395 ENOG4107TYH extracellular solute-binding protein family 1 GQF42_RS40400 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GQF42_RS40420 ENOG4105EW9 transcriptional regulator AsnC family GQF42_RS40425 ENOG4108UMN azlc family GQF42_RS40435 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GQF42_RS40460 ENOG4105FKQ transcriptional regulator GQF42_RS40470 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GQF42_RS40490 ENOG4105CHR reductase GQF42_RS40495 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GQF42_RS40500 ENOG4105D52 delta-aminolevulinic acid dehydratase GQF42_RS40510 ENOG4105CPC Aldo Keto reductase GQF42_RS40520 ENOG4105CHR reductase GQF42_RS40545 ENOG4107R3A FAD linked oxidase domain protein GQF42_RS40550 ENOG4107TE5 Lipid kinase GQF42_RS40570 ENOG4105CVM Molybdenum cofactor synthesis domain protein GQF42_RS40580 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GQF42_RS40585 ENOG4105DND Transcriptional regulator GQF42_RS40590 ENOG4105EZR dyp-type peroxidase family protein GQF42_RS40635 ENOG4105CPC Aldo Keto reductase GQF42_RS40640 ENOG4105VUF Transcriptional regulator GQF42_RS40645 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GQF42_RS40785 ENOG4105ECQ AraC Family Transcriptional Regulator GQF42_RS40810 ENOG4107RQ0 Maleylacetate reductase GQF42_RS40820 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS40830 ENOG4105CJ1 ABC, transporter GQF42_RS40850 ENOG4105NRA 50s ribosomal protein l31 type b GQF42_RS40865 ENOG4105ETS cytosine purines uracil thiamine allantoin GQF42_RS40870 ENOG4106HK8 GPR1 FUN34 yaaH family protein GQF42_RS40910 ENOG4108KPJ rna polymerase sigma factor GQF42_RS40945 ENOG4105YVS arsR family transcriptional regulator GQF42_RS40960 ENOG4105ECQ AraC Family Transcriptional Regulator GQF42_RS40975 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GQF42_RS41030 ENOG4108JCI Transcriptional regulator GQF42_RS41035 ENOG4108Z7F N-acetyltransferase GQF42_RS41040 ENOG4105BZU Histidine kinase GQF42_RS41045 ENOG4105WH1 Two component transcriptional regulator luxr family GQF42_RS41055 ENOG4108I69 Glycosyl transferases group 1 GQF42_RS41075 ENOG41082SX arsR family transcriptional regulator GQF42_RS41095 ENOG410905P Pyridoxamine 5-phosphate GQF42_RS41130 ENOG4105DVW rieske (2Fe-2S) GQF42_RS41140 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GQF42_RS41145 ENOG4105C26 Dehydrogenase GQF42_RS41150 ENOG4108IJ7 Glycine betaine GQF42_RS41155 ENOG4107SQ8 Glycine betaine GQF42_RS41170 ENOG4105CEY Amp-dependent synthetase and ligase GQF42_RS41175 ENOG41069M3 Transcriptional regulator GQF42_RS41185 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GQF42_RS41220 ENOG41061H0 Monooxygenase GQF42_RS41240 ENOG4105D74 hydrolase GQF42_RS41245 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GQF42_RS41255 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GQF42_RS41260 ENOG4105CFG Acts as a chaperone (By similarity) GQF42_RS41295 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GQF42_RS41315 ENOG4105MKU Transcriptional regulator GQF42_RS41325 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase GQF42_RS41420 ENOG4105GRZ Ycii-related protein GQF42_RS41425 ENOG4105CHP RNA polymerase GQF42_RS41430 ENOG4105EJ2 Transcriptional regulator GQF42_RS41495 ENOG4105CT3 Monooxygenase GQF42_RS41530 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GQF42_RS41535 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GQF42_RS41545 ENOG4108SGR YheO domain-containing protein GQF42_RS41560 ENOG4107S5I aldo keto reductase GQF42_RS41565 ENOG4105CM2 brancheD-chain amino acid aminotransferase GQF42_RS41570 ENOG4105CPF Cell wall formation (By similarity) GQF42_RS41595 ENOG4107SET aldo keto reductase GQF42_RS41610 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GQF42_RS41630 ENOG4105EXW epimerase dehydratase GQF42_RS41665 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GQF42_RS41680 ENOG4105PDP Short chain dehydrogenase GQF42_RS41710 ENOG4105DYW oxidoreductase GQF42_RS41720 ENOG4107YPT transcriptional regulator GQF42_RS41740 ENOG4105CXK mandelate racemase muconate lactonizing GQF42_RS41775 ENOG4105EX0 alpha-galactosidase GQF42_RS41780 ENOG4105E2R ROK family GQF42_RS41795 ENOG4105DIA mandelate racemase muconate lactonizing GQF42_RS41800 ENOG41062B0 ABC transporter, permease GQF42_RS41805 ENOG4108HWV )-transporter GQF42_RS41830 ENOG4105FS7 Transcriptional regulator GQF42_RS41845 ENOG4105C0R drug resistance transporter emrb qaca subfamily GQF42_RS41890 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GQF42_RS41910 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GQF42_RS41955 ENOG4105K4I Scp-like extracellular GQF42_RS41995 ENOG4107SCK Monooxygenase GQF42_RS42070 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GQF42_RS42155 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GQF42_RS42170 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GQF42_RS42185 ENOG4107S5I aldo keto reductase GQF42_RS42215 ENOG4105KVH Transcriptional regulator GQF42_RS42295 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GQF42_RS42320 ENOG4105CKI cobalamin synthesis protein GQF42_RS42325 ENOG41068HZ 50S ribosomal protein L32 GQF42_RS42345 ENOG4105DIK (ABC) transporter GQF42_RS42350 ENOG4105DSE periplasmic solute binding protein GQF42_RS42390 ENOG4108KB2 LysR family Transcriptional regulator GQF42_RS42395 ENOG4105CHR reductase GQF42_RS42530 ENOG4108M0H Extracellular lipase GQF42_RS42595 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS42600 ENOG4107FKK extracellular solute-binding protein family 1 GQF42_RS42630 ENOG4105CPC Aldo Keto reductase GQF42_RS42685 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GQF42_RS42690 ENOG4106NZI LysR family Transcriptional regulator GQF42_RS42740 ENOG410834F Transcriptional regulator GQF42_RS42745 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) GQF42_RS42750 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) GQF42_RS42805 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GQF42_RS42850 ENOG4108IUZ ABC transporter GQF42_RS42860 ENOG4105C32 Amino acid ABC transporter (Permease) GQF42_RS42870 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GQF42_RS42885 ENOG4105DTD Dehydrogenase GQF42_RS42955 ENOG4107RIZ hflk protein GQF42_RS43010 ENOG4108HKT sucrose-6-phosphate hydrolase GQF42_RS43020 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GQF42_RS43025 ENOG4105DRS transport system, permease GQF42_RS43035 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS43045 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) GQF42_RS43060 ENOG4105I9Z UPF0264 protein GQF42_RS43095 ENOG4105PY6 Phenolic acid decarboxylase GQF42_RS43105 ENOG4105D4K integrase catalytic GQF42_RS43225 ENOG4105CH6 catalase GQF42_RS43245 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GQF42_RS43255 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GQF42_RS43280 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GQF42_RS43350 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GQF42_RS43355 ENOG4107XGZ Hydrolase GQF42_RS43360 ENOG4105KVH Transcriptional regulator GQF42_RS43425 ENOG4107SVN transposase GQF42_RS43440 ENOG4108HMN Caspase domain GQF42_RS43495 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GQF42_RS43515 ENOG4105KVH Transcriptional regulator GQF42_RS43520 ENOG4108FKH Transglycosylase SLT domain GQF42_RS43525 ENOG4105U5Y Transcriptional regulator GQF42_RS43535 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GQF42_RS43590 ENOG4105BZ1 (ABC) transporter GQF42_RS43610 ENOG4105CJ1 ABC, transporter GQF42_RS43655 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GQF42_RS43670 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS43680 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GQF42_RS43690 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GQF42_RS43700 ENOG4105DSG hydrolase family 43 GQF42_RS43720 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS43730 ENOG4105ETE Transcriptional regulator (LacI family GQF42_RS43765 ENOG4105EX0 alpha-galactosidase GQF42_RS43805 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GQF42_RS43835 ENOG4105EMU Dehydrogenase GQF42_RS43930 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GQF42_RS43935 ENOG4105CQB FAD linked oxidase domain protein GQF42_RS43950 ENOG4108W6C Dehydrogenase GQF42_RS43985 ENOG410600T transposase GQF42_RS44020 ENOG4108U8T Mannosyltransferase GQF42_RS44145 ENOG4105CPC Aldo Keto reductase GQF42_RS44180 ENOG4105CHP RNA polymerase GQF42_RS44235 ENOG41085W3 Transposase GQF42_RS44240 ENOG4106NZI LysR family Transcriptional regulator GQF42_RS44250 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GQF42_RS44260 ENOG4105CHR reductase GQF42_RS44305 ENOG4105EV9 Alpha Beta Hydrolase GQF42_RS44340 ENOG4105CPC Aldo Keto reductase GQF42_RS44350 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GQF42_RS44365 ENOG4105DDW LysR family Transcriptional regulator GQF42_RS44405 ENOG4106HB6 Alpha beta hydrolase GQF42_RS44425 ENOG4107YB1 Trehalose corynomycolyl transferase GQF42_RS44470 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GQF42_RS44525 ENOG4108KQ5 Integrase catalytic subunit GQF42_RS44535 ENOG4107SVN transposase GQF42_RS44580 ENOG4105D5G Transposase