locus-tag	class	description
MCU78_RS00050	COG3547	Transposase (IS116 IS110 IS902 family)
MCU78_RS00085	COG0494	nUDIX hydrolase
MCU78_RS00100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCU78_RS00120	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS00130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MCU78_RS00140	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MCU78_RS00150	COG1181	Belongs to the D-alanine--D-alanine ligase family
MCU78_RS00195	COG2197	response regulator
MCU78_RS00225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCU78_RS00225	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MCU78_RS00305	COG2207	Transcriptional regulator
MCU78_RS00310	COG0596	Alpha beta hydrolase
MCU78_RS00345	COG1595	DNA-templated transcription, initiation
MCU78_RS00365	COG0531	amino acid
MCU78_RS00370	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MCU78_RS00370	COG1672	PFAM Archaeal ATPase
MCU78_RS00375	COG1819	glycosyl
MCU78_RS00380	COG3321	synthase
MCU78_RS00380	COG0604	alcohol dehydrogenase
MCU78_RS00385	COG3321	synthase
MCU78_RS00385	COG0604	alcohol dehydrogenase
MCU78_RS00390	COG0604	alcohol dehydrogenase
MCU78_RS00390	COG3321	synthase
MCU78_RS00405	COG2267	carboxylic ester hydrolase activity
MCU78_RS00425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS00430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS00450	COG4865	methylaspartate mutase activity
MCU78_RS00465	COG0604	alcohol dehydrogenase
MCU78_RS00465	COG3321	synthase
MCU78_RS00470	COG3321	synthase
MCU78_RS00470	COG0604	alcohol dehydrogenase
MCU78_RS00490	COG0477	Major facilitator Superfamily
MCU78_RS00495	COG2197	response regulator
MCU78_RS00505	COG1136	(ABC) transporter
MCU78_RS00520	COG0318	PFAM AMP-dependent synthetase and ligase
MCU78_RS00525	COG0445	tRNA wobble uridine modification
MCU78_RS00530	COG1755	Isoprenylcysteine carboxyl methyltransferase
MCU78_RS00545	COG0655	NAD(P)H dehydrogenase (quinone) activity
MCU78_RS00550	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS00575	COG2072	flavoprotein involved in K transport
MCU78_RS00620	COG0583	DNA-binding transcription factor activity
MCU78_RS00655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS00705	COG0714	Associated with various cellular activities
MCU78_RS00740	COG0154	amidase activity
MCU78_RS00760	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS00765	COG2814	Major facilitator Superfamily
MCU78_RS00790	COG0668	transmembrane transport
MCU78_RS00805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MCU78_RS00810	COG0604	alcohol dehydrogenase
MCU78_RS00870	COG2226	methyltransferase
MCU78_RS00945	COG1695	Transcriptional regulator
MCU78_RS00955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCU78_RS00990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS00995	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS01010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCU78_RS01010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCU78_RS01035	COG2271	Major facilitator Superfamily
MCU78_RS01085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MCU78_RS01095	COG1595	DNA-templated transcription, initiation
MCU78_RS01150	COG1113	amino acid transport
MCU78_RS01170	COG1733	regulation of RNA biosynthetic process
MCU78_RS01180	COG4585	Histidine kinase
MCU78_RS01195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MCU78_RS01235	COG0346	lactoylglutathione lyase activity
MCU78_RS01290	COG3511	phospholipase C
MCU78_RS01395	COG0326	Molecular chaperone. Has ATPase activity
MCU78_RS01410	COG2239	Acts as a magnesium transporter
MCU78_RS01420	COG1309	transcriptional regulator
MCU78_RS01430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCU78_RS01430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCU78_RS01435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MCU78_RS01435	COG1796	DNA polymerase
MCU78_RS01440	COG1357	PFAM Pentapeptide repeats (8 copies)
MCU78_RS01445	COG2124	cytochrome p450
MCU78_RS01480	COG3268	Saccharopine dehydrogenase
MCU78_RS01490	COG1063	alcohol dehydrogenase
MCU78_RS01495	COG0156	8-amino-7-oxononanoate synthase activity
MCU78_RS01530	COG1609	Transcriptional regulator
MCU78_RS01535	COG1129	ABC transporter
MCU78_RS01545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MCU78_RS01555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS01560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCU78_RS01565	COG2409	Drug exporters of the RND superfamily
MCU78_RS01575	COG1755	Isoprenylcysteine carboxyl methyltransferase
MCU78_RS01585	COG0154	amidase activity
MCU78_RS01590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MCU78_RS01625	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCU78_RS01625	COG1902	pentaerythritol trinitrate reductase activity
MCU78_RS01655	COG0784	Response regulator, receiver
MCU78_RS01665	COG4251	negative regulation of phosphorylation
MCU78_RS01700	COG2197	response regulator
MCU78_RS01705	COG4585	Histidine kinase
MCU78_RS01725	COG0475	glutathione-regulated potassium exporter activity
MCU78_RS01765	COG2826	transposase and inactivated derivatives, IS30 family
MCU78_RS01785	COG1970	mechanosensitive ion channel activity
MCU78_RS01795	COG0477	Major facilitator Superfamily
MCU78_RS01820	COG1064	alcohol dehydrogenase
MCU78_RS01835	COG4336	lyase activity
MCU78_RS01860	COG3979	chitinase
MCU78_RS01865	COG0586	Pfam SNARE associated Golgi protein
MCU78_RS01880	COG3226	Transcriptional regulator
MCU78_RS01895	COG0477	Major facilitator Superfamily
MCU78_RS01905	COG1819	glycosyl
MCU78_RS01945	COG3226	Transcriptional regulator
MCU78_RS01960	COG0604	alcohol dehydrogenase
MCU78_RS01960	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS01960	COG3321	synthase
MCU78_RS02005	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS02020	COG0242	peptide deformylase activity
MCU78_RS02030	COG3442	glutamine amidotransferase
MCU78_RS02035	COG0205	6-phosphofructokinase activity
MCU78_RS02075	COG3387	PFAM Glycoside hydrolase 15-related
MCU78_RS02115	COG0829	nickel cation binding
MCU78_RS02120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MCU78_RS02130	COG0804	urea catabolic process
MCU78_RS02135	COG0832	Belongs to the urease beta subunit family
MCU78_RS02140	COG0831	urea catabolic process
MCU78_RS02155	COG1687	branched-chain amino acid
MCU78_RS02185	COG0740	serine-type endopeptidase activity
MCU78_RS02195	COG0791	NLP P60 protein
MCU78_RS02220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MCU78_RS02225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MCU78_RS02230	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MCU78_RS02235	COG2226	methyltransferase
MCU78_RS02265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MCU78_RS02270	COG3663	DNA glycosylase
MCU78_RS02280	COG1940	carbohydrate kinase activity
MCU78_RS02285	COG2188	Transcriptional regulator
MCU78_RS02290	COG2267	carboxylic ester hydrolase activity
MCU78_RS02310	COG4585	Histidine kinase
MCU78_RS02315	COG2197	response regulator
MCU78_RS02330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCU78_RS02335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MCU78_RS02375	COG1522	sequence-specific DNA binding
MCU78_RS02380	COG0419	ATPase involved in DNA repair
MCU78_RS02385	COG0420	3'-5' exonuclease activity
MCU78_RS02400	COG1739	Uncharacterized protein family UPF0029
MCU78_RS02430	COG1832	CoA-binding protein
MCU78_RS02530	COG0110	maltose O-acetyltransferase activity
MCU78_RS02560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCU78_RS02565	COG0477	Major facilitator Superfamily
MCU78_RS02570	COG2264	protein methyltransferase activity
MCU78_RS02575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCU78_RS02620	COG1309	transcriptional regulator
MCU78_RS02640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MCU78_RS02655	COG2706	6-phosphogluconolactonase activity
MCU78_RS02665	COG1522	sequence-specific DNA binding
MCU78_RS02690	COG2072	flavoprotein involved in K transport
MCU78_RS02700	COG1139	Iron-sulfur cluster binding protein
MCU78_RS02705	COG1556	Lactate utilization protein
MCU78_RS02715	COG1132	(ABC) transporter
MCU78_RS02720	COG1846	Transcriptional regulator
MCU78_RS02735	COG1132	(ABC) transporter
MCU78_RS02745	COG1733	regulation of RNA biosynthetic process
MCU78_RS02780	COG2018	Roadblock/LC7 domain
MCU78_RS02795	COG3511	phospholipase C
MCU78_RS02835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MCU78_RS02840	COG0494	nUDIX hydrolase
MCU78_RS02870	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MCU78_RS02870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MCU78_RS02885	COG1124	(ABC) transporter
MCU78_RS02890	COG0444	Belongs to the ABC transporter superfamily
MCU78_RS02895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCU78_RS02900	COG0601	transmembrane transport
MCU78_RS02910	COG1609	Transcriptional regulator
MCU78_RS02920	COG1175	transmembrane transport
MCU78_RS02925	COG0395	ABC-type sugar transport system, permease component
MCU78_RS02965	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MCU78_RS02975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MCU78_RS02990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MCU78_RS03040	COG2205	protein histidine kinase activity
MCU78_RS03045	COG0745	RESPONSE REGULATOR receiver
MCU78_RS03050	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS03070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MCU78_RS03075	COG0121	glutamine amidotransferase
MCU78_RS03080	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MCU78_RS03100	COG3360	Dodecin
MCU78_RS03140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MCU78_RS03190	COG3845	ABC transporter
MCU78_RS03205	COG3537	Alpha-1,2-mannosidase
MCU78_RS03210	COG0531	amino acid
MCU78_RS03215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MCU78_RS03235	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MCU78_RS03240	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
MCU78_RS03245	COG0531	amino acid
MCU78_RS03350	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MCU78_RS03385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MCU78_RS03405	COG1191	sigma factor activity
MCU78_RS03415	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MCU78_RS03450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MCU78_RS03460	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MCU78_RS03485	COG3629	intracellular signal transduction
MCU78_RS03485	COG3903	Transcriptional regulator
MCU78_RS03505	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS03515	COG0367	asparagine synthase
MCU78_RS03525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MCU78_RS03530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MCU78_RS03535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MCU78_RS03540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MCU78_RS03545	COG0436	Aminotransferase
MCU78_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS03610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCU78_RS03620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MCU78_RS03630	COG0784	Response regulator, receiver
MCU78_RS03630	COG2205	protein histidine kinase activity
MCU78_RS03630	COG5002	protein histidine kinase activity
MCU78_RS03680	COG2986	histidine ammonia-lyase
MCU78_RS03690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCU78_RS03705	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS03735	COG0501	Belongs to the peptidase M48B family
MCU78_RS03740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MCU78_RS03760	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MCU78_RS03775	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS03780	COG0515	serine threonine protein kinase
MCU78_RS03790	COG1132	(ABC) transporter
MCU78_RS03795	COG1132	(ABC) transporter
MCU78_RS03820	COG0242	peptide deformylase activity
MCU78_RS03835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS03840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS03865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS03870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS03890	COG1309	transcriptional regulator
MCU78_RS03910	COG4221	oxidoreductase activity
MCU78_RS03945	COG0583	DNA-binding transcription factor activity
MCU78_RS03955	COG1024	Enoyl-CoA hydratase
MCU78_RS03965	COG1250	3-hydroxyacyl-CoA dehydrogenase
MCU78_RS03970	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS03995	COG2234	aminopeptidase activity
MCU78_RS04000	COG0519	Catalyzes the synthesis of GMP from XMP
MCU78_RS04040	COG4221	oxidoreductase activity
MCU78_RS04055	COG0247	lactate metabolic process
MCU78_RS04055	COG0277	FAD linked oxidase domain protein
MCU78_RS04060	COG1007	ATP synthesis coupled electron transport
MCU78_RS04065	COG1006	Multisubunit Na H antiporter MnhC subunit
MCU78_RS04070	COG2111	Na H antiporter
MCU78_RS04110	COG0842	Transport permease protein
MCU78_RS04110	COG1129	ABC transporter
MCU78_RS04115	COG0113	porphobilinogen synthase activity
MCU78_RS04120	COG0181	hydroxymethylbilane synthase activity
MCU78_RS04125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MCU78_RS04130	COG0408	coproporphyrinogen oxidase activity
MCU78_RS04135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MCU78_RS04160	COG2409	Drug exporters of the RND superfamily
MCU78_RS04165	COG2814	Major facilitator Superfamily
MCU78_RS04170	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS04185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCU78_RS04190	COG0028	Belongs to the TPP enzyme family
MCU78_RS04210	COG3321	synthase
MCU78_RS04210	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS04210	COG0604	alcohol dehydrogenase
MCU78_RS04225	COG2409	Drug exporters of the RND superfamily
MCU78_RS04235	COG3290	protein histidine kinase activity
MCU78_RS04240	COG5001	Diguanylate cyclase
MCU78_RS04255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MCU78_RS04280	COG1024	Enoyl-CoA hydratase
MCU78_RS04295	COG1742	UPF0060 membrane protein
MCU78_RS04305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MCU78_RS04350	COG0531	amino acid
MCU78_RS04365	COG1802	Transcriptional regulator
MCU78_RS04375	COG3938	Belongs to the proline racemase family
MCU78_RS04395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MCU78_RS04405	COG0006	proline dipeptidase activity
MCU78_RS04420	COG0386	Belongs to the glutathione peroxidase family
MCU78_RS04445	COG0667	Aldo Keto reductase
MCU78_RS04460	COG2814	Major facilitator Superfamily
MCU78_RS04465	COG0243	molybdopterin cofactor binding
MCU78_RS04505	COG2197	response regulator
MCU78_RS04565	COG0488	(ABC) transporter
MCU78_RS04570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MCU78_RS04585	COG0657	acetylesterase activity
MCU78_RS04595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCU78_RS04600	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MCU78_RS04605	COG2080	2 iron, 2 sulfur cluster binding
MCU78_RS04620	COG0488	(ABC) transporter
MCU78_RS04645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MCU78_RS04665	COG0076	glutamate decarboxylase activity
MCU78_RS04675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCU78_RS04755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MCU78_RS04765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCU78_RS04765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MCU78_RS04775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MCU78_RS04830	COG0823	Involved in the tonB-independent uptake of proteins
MCU78_RS04870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MCU78_RS04895	COG2755	lipolytic protein G-D-S-L family
MCU78_RS04910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MCU78_RS04915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MCU78_RS04930	COG1657	PFAM Prenyltransferase squalene oxidase
MCU78_RS04940	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MCU78_RS04950	COG1562	ergosterol biosynthetic process
MCU78_RS04955	COG1134	teichoic acid transport
MCU78_RS04955	COG1388	LysM domain
MCU78_RS05000	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MCU78_RS05010	COG1024	Enoyl-CoA hydratase
MCU78_RS05065	COG0596	Alpha beta hydrolase
MCU78_RS05090	COG2936	dipeptidyl-peptidase activity
MCU78_RS05095	COG2936	dipeptidyl-peptidase activity
MCU78_RS05105	COG0789	Transcriptional regulator
MCU78_RS05120	COG1250	3-hydroxyacyl-CoA dehydrogenase
MCU78_RS05120	COG1024	Enoyl-CoA hydratase
MCU78_RS05125	COG0183	Belongs to the thiolase family
MCU78_RS05130	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS05135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MCU78_RS05145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MCU78_RS05150	COG1515	deoxyribonuclease V activity
MCU78_RS05165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MCU78_RS05225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS05230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCU78_RS05240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MCU78_RS05240	COG0825	malonyl-CoA metabolic process
MCU78_RS05245	COG0778	Nitroreductase
MCU78_RS05270	COG0179	Fumarylacetoacetate (FAA) hydrolase
MCU78_RS05325	COG2850	peptidyl-arginine hydroxylation
MCU78_RS05345	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS05350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MCU78_RS05360	COG1846	Transcriptional regulator
MCU78_RS05385	COG2154	pterin-4-alpha-carbinolamine dehydratase
MCU78_RS05400	COG2197	response regulator
MCU78_RS05410	COG0531	amino acid
MCU78_RS05425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCU78_RS05485	COG1819	glycosyl
MCU78_RS05500	COG2132	Multicopper oxidase
MCU78_RS05570	COG0542	response to heat
MCU78_RS05630	COG2197	response regulator
MCU78_RS05660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS05665	COG3433	isochorismatase activity
MCU78_RS05665	COG1535	isochorismatase
MCU78_RS05670	COG1021	2,3-dihydroxybenzoate-AMP ligase
MCU78_RS05675	COG1169	isochorismate synthase
MCU78_RS05680	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS05690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCU78_RS05720	COG1518	maintenance of DNA repeat elements
MCU78_RS05730	COG0667	Aldo Keto reductase
MCU78_RS05740	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MCU78_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS05855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCU78_RS05875	COG0596	Alpha beta hydrolase
MCU78_RS05880	COG2207	Transcriptional regulator
MCU78_RS05885	COG0604	alcohol dehydrogenase
MCU78_RS05900	COG0604	alcohol dehydrogenase
MCU78_RS05905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCU78_RS05905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCU78_RS05910	COG2301	Belongs to the HpcH HpaI aldolase family
MCU78_RS05920	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS05925	COG0688	phosphatidylethanolamine metabolic process
MCU78_RS05935	COG3547	Transposase (IS116 IS110 IS902 family)
MCU78_RS05940	COG1929	Belongs to the glycerate kinase type-1 family
MCU78_RS05945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MCU78_RS05960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MCU78_RS05970	COG0515	serine threonine protein kinase
MCU78_RS05970	COG2815	serine threonine protein kinase
MCU78_RS05990	COG0542	response to heat
MCU78_RS06005	COG0483	inositol monophosphate 1-phosphatase activity
MCU78_RS06010	COG0095	Lipoate-protein ligase
MCU78_RS06050	COG2910	NAD(P)H-binding
MCU78_RS06065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MCU78_RS06070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCU78_RS06080	COG1335	isochorismatase
MCU78_RS06085	COG0405	Gamma-glutamyltransferase
MCU78_RS06090	COG2755	lipolytic protein G-D-S-L family
MCU78_RS06095	COG1959	2 iron, 2 sulfur cluster binding
MCU78_RS06105	COG0765	amino acid transport
MCU78_RS06110	COG0765	amino acid transport
MCU78_RS06115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCU78_RS06120	COG1126	abc transporter atp-binding protein
MCU78_RS06150	COG1846	Transcriptional regulator
MCU78_RS06160	COG0708	Exodeoxyribonuclease III
MCU78_RS06165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MCU78_RS06190	COG0745	RESPONSE REGULATOR receiver
MCU78_RS06255	COG1024	Enoyl-CoA hydratase
MCU78_RS06270	COG1024	Enoyl-CoA hydratase
MCU78_RS06275	COG1024	Enoyl-CoA hydratase
MCU78_RS06285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS06300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS06315	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS06325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MCU78_RS06345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MCU78_RS06355	COG0443	Heat shock 70 kDa protein
MCU78_RS06375	COG1940	carbohydrate kinase activity
MCU78_RS06395	COG2188	Transcriptional regulator
MCU78_RS06430	COG4266	Belongs to the allantoicase family
MCU78_RS06435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MCU78_RS06440	COG1414	Transcriptional regulator
MCU78_RS06455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MCU78_RS06465	COG1132	(ABC) transporter
MCU78_RS06475	COG2233	PERMEase
MCU78_RS06490	COG2351	hydroxyisourate hydrolase activity
MCU78_RS06495	COG0583	DNA-binding transcription factor activity
MCU78_RS06505	COG0667	Aldo Keto reductase
MCU78_RS06515	COG2205	protein histidine kinase activity
MCU78_RS06520	COG0745	RESPONSE REGULATOR receiver
MCU78_RS06525	COG0438	transferase activity, transferring glycosyl groups
MCU78_RS06570	COG0300	oxidoreductase activity
MCU78_RS06615	COG3622	Belongs to the hyi family
MCU78_RS06620	COG2084	Dehydrogenase
MCU78_RS06625	COG3960	tartronate-semialdehyde synthase activity
MCU78_RS06640	COG0583	DNA-binding transcription factor activity
MCU78_RS06645	COG2130	NADP-dependent
MCU78_RS06650	COG0318	PFAM AMP-dependent synthetase and ligase
MCU78_RS06655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCU78_RS06695	COG1285	pathogenesis
MCU78_RS06710	COG3540	Alkaline phosphatase
MCU78_RS06720	COG0477	Major facilitator Superfamily
MCU78_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS06735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS06750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCU78_RS06755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCU78_RS06760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCU78_RS06765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCU78_RS06770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS06780	COG0477	Major facilitator Superfamily
MCU78_RS06805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MCU78_RS06825	COG2252	PERMEase
MCU78_RS06830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCU78_RS06845	COG3835	regulator
MCU78_RS06850	COG2964	Protein conserved in bacteria
MCU78_RS06855	COG0133	tryptophan synthase activity
MCU78_RS06895	COG1802	Transcriptional regulator
MCU78_RS06925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MCU78_RS06935	COG1162	GTPase activity
MCU78_RS06960	COG0175	sulfate reduction
MCU78_RS06965	COG0529	Catalyzes the synthesis of activated sulfate
MCU78_RS06985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MCU78_RS06990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCU78_RS07010	COG1280	lysine exporter protein (LysE YggA)
MCU78_RS07060	COG0583	DNA-binding transcription factor activity
MCU78_RS07065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCU78_RS07075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCU78_RS07080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MCU78_RS07150	COG1278	Cold shock
MCU78_RS07200	COG0596	Alpha beta hydrolase
MCU78_RS07225	COG3253	May function as heme-dependent peroxidase
MCU78_RS07235	COG0183	Belongs to the thiolase family
MCU78_RS07245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MCU78_RS07265	COG0183	Belongs to the thiolase family
MCU78_RS07270	COG1250	3-hydroxyacyl-CoA dehydrogenase
MCU78_RS07270	COG1024	Enoyl-CoA hydratase
MCU78_RS07295	COG0531	amino acid
MCU78_RS07300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MCU78_RS07305	COG4214	carbohydrate transport
MCU78_RS07315	COG4213	ABC transporter substrate-binding protein
MCU78_RS07330	COG0395	ABC-type sugar transport system, permease component
MCU78_RS07335	COG1175	transmembrane transport
MCU78_RS07340	COG1653	transport
MCU78_RS07375	COG1309	transcriptional regulator
MCU78_RS07390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MCU78_RS07415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MCU78_RS07425	COG1917	Cupin 2, conserved barrel domain protein
MCU78_RS07440	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS07460	COG1024	Enoyl-CoA hydratase
MCU78_RS07465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MCU78_RS07480	COG4977	sequence-specific DNA binding
MCU78_RS07485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MCU78_RS07495	COG2040	homocysteine
MCU78_RS07525	COG1799	cell septum assembly
MCU78_RS07540	COG1396	sequence-specific DNA binding
MCU78_RS07595	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MCU78_RS07605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCU78_RS07610	COG0531	amino acid
MCU78_RS07620	COG2124	cytochrome p450
MCU78_RS07645	COG0655	NAD(P)H dehydrogenase (quinone) activity
MCU78_RS07650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MCU78_RS07665	COG0569	domain protein
MCU78_RS07700	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MCU78_RS07705	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MCU78_RS07710	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MCU78_RS07725	COG0756	dUTP diphosphatase activity
MCU78_RS07750	COG2205	protein histidine kinase activity
MCU78_RS07755	COG0745	RESPONSE REGULATOR receiver
MCU78_RS07770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MCU78_RS07805	COG1435	thymidine kinase activity
MCU78_RS07820	COG1042	CoA-binding domain protein
MCU78_RS07820	COG0045	succinate-CoA ligase (ADP-forming) activity
MCU78_RS07820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCU78_RS07825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MCU78_RS07830	COG1802	Transcriptional regulator
MCU78_RS07845	COG0612	Peptidase, M16
MCU78_RS07850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MCU78_RS07870	COG2197	response regulator
MCU78_RS07875	COG4585	Histidine kinase
MCU78_RS07885	COG0187	DNA topoisomerase II activity
MCU78_RS07900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MCU78_RS07905	COG2186	Transcriptional regulator
MCU78_RS07910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MCU78_RS07945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MCU78_RS07955	COG0588	phosphoglycerate mutase activity
MCU78_RS07960	COG0488	(ABC) transporter
MCU78_RS07985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MCU78_RS07990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MCU78_RS07995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MCU78_RS08020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MCU78_RS08030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MCU78_RS08035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MCU78_RS08045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MCU78_RS08065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCU78_RS08075	COG2205	protein histidine kinase activity
MCU78_RS08085	COG1126	abc transporter atp-binding protein
MCU78_RS08090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCU78_RS08095	COG0765	amino acid transport
MCU78_RS08100	COG0765	amino acid transport
MCU78_RS08105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCU78_RS08120	COG2137	regulation of response to DNA damage stimulus
MCU78_RS08125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MCU78_RS08145	COG1201	RNA secondary structure unwinding
MCU78_RS08175	COG1396	sequence-specific DNA binding
MCU78_RS08180	COG1058	Belongs to the CinA family
MCU78_RS08180	COG1546	Belongs to the CinA family
MCU78_RS08190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCU78_RS08200	COG1674	ftsk spoiiie
MCU78_RS08215	COG2208	phosphoserine phosphatase activity
MCU78_RS08215	COG2770	Histidine kinase
MCU78_RS08225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MCU78_RS08245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MCU78_RS08250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MCU78_RS08265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MCU78_RS08270	COG0612	Peptidase, M16
MCU78_RS08275	COG1185	polyribonucleotide nucleotidyltransferase activity
MCU78_RS08280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MCU78_RS08290	COG1674	ftsk spoiiie
MCU78_RS08325	COG1404	Belongs to the peptidase S8 family
MCU78_RS08350	COG1404	Belongs to the peptidase S8 family
MCU78_RS08375	COG0515	serine threonine protein kinase
MCU78_RS08375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCU78_RS08385	COG0455	bacterial-type flagellum organization
MCU78_RS08400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MCU78_RS08405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MCU78_RS08415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MCU78_RS08430	COG0779	Required for maturation of 30S ribosomal subunits
MCU78_RS08450	COG0442	prolyl-tRNA aminoacylation
MCU78_RS08465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MCU78_RS08470	COG0750	zinc metalloprotease
MCU78_RS08475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MCU78_RS08485	COG2197	response regulator
MCU78_RS08490	COG4585	Histidine kinase
MCU78_RS08500	COG2508	Transcriptional regulator
MCU78_RS08525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MCU78_RS08535	COG1176	ABC-type spermidine putrescine transport system, permease component I
MCU78_RS08540	COG3842	ATPase activity
MCU78_RS08555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MCU78_RS08575	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS08585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MCU78_RS08605	COG3842	ATPase activity
MCU78_RS08620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MCU78_RS08630	COG0233	cytoplasmic translational termination
MCU78_RS08635	COG0528	UMP kinase activity
MCU78_RS08640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MCU78_RS08645	COG0052	Belongs to the universal ribosomal protein uS2 family
MCU78_RS08660	COG1191	sigma factor activity
MCU78_RS08675	COG0792	nuclease activity
MCU78_RS08690	COG0681	Belongs to the peptidase S26 family
MCU78_RS08695	COG0681	Belongs to the peptidase S26 family
MCU78_RS08705	COG0681	Belongs to the peptidase S26 family
MCU78_RS08710	COG0335	large ribosomal subunit rRNA binding
MCU78_RS08715	COG0336	Belongs to the RNA methyltransferase TrmD family
MCU78_RS08720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MCU78_RS08725	COG1837	Belongs to the UPF0109 family
MCU78_RS08730	COG0228	four-way junction DNA binding
MCU78_RS08740	COG0442	prolyl-tRNA aminoacylation
MCU78_RS08745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MCU78_RS08755	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MCU78_RS08785	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MCU78_RS08800	COG0546	phosphoglycolate phosphatase activity
MCU78_RS08815	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MCU78_RS08820	COG3321	synthase
MCU78_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS08820	COG0604	alcohol dehydrogenase
MCU78_RS08825	COG0583	DNA-binding transcription factor activity
MCU78_RS08870	COG0477	Major facilitator Superfamily
MCU78_RS08885	COG1254	Belongs to the acylphosphatase family
MCU78_RS08900	COG1733	regulation of RNA biosynthetic process
MCU78_RS08905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MCU78_RS08910	COG0571	ribonuclease III activity
MCU78_RS08915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MCU78_RS08930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MCU78_RS08935	COG0742	ribosomal rna small subunit methyltransferase
MCU78_RS08945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MCU78_RS08950	COG1461	Dihydroxyacetone kinase
MCU78_RS08955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MCU78_RS08960	COG0351	phosphomethylpyrimidine kinase
MCU78_RS08980	COG1181	Belongs to the D-alanine--D-alanine ligase family
MCU78_RS08985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MCU78_RS08995	COG1920	GTP binding
MCU78_RS09005	COG0776	regulation of translation
MCU78_RS09015	COG0066	3-isopropylmalate dehydratase activity
MCU78_RS09020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MCU78_RS09025	COG1414	Transcriptional regulator
MCU78_RS09070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCU78_RS09075	COG0179	Fumarylacetoacetate (FAA) hydrolase
MCU78_RS09095	COG2018	Roadblock/LC7 domain
MCU78_RS09115	COG2018	Roadblock/LC7 domain
MCU78_RS09145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MCU78_RS09150	COG5492	domain, Protein
MCU78_RS09155	COG2353	YceI-like domain
MCU78_RS09160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MCU78_RS09175	COG0535	radical SAM domain protein
MCU78_RS09185	COG1132	(ABC) transporter
MCU78_RS09190	COG0477	Major facilitator Superfamily
MCU78_RS09195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MCU78_RS09200	COG0473	3-isopropylmalate dehydrogenase activity
MCU78_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS09240	COG0506	proline dehydrogenase activity
MCU78_RS09245	COG3835	regulator
MCU78_RS09275	COG2124	cytochrome p450
MCU78_RS09285	COG0477	Major facilitator Superfamily
MCU78_RS09290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MCU78_RS09295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MCU78_RS09300	COG0440	acetolactate synthase activity
MCU78_RS09320	COG0667	Aldo Keto reductase
MCU78_RS09325	COG0789	Transcriptional regulator
MCU78_RS09345	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MCU78_RS09345	COG1672	PFAM Archaeal ATPase
MCU78_RS09360	COG0504	CTP synthase activity
MCU78_RS09365	COG2409	Drug exporters of the RND superfamily
MCU78_RS09375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCU78_RS09385	COG0154	amidase activity
MCU78_RS09390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCU78_RS09400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MCU78_RS09415	COG2197	response regulator
MCU78_RS09420	COG4585	Histidine kinase
MCU78_RS09495	COG0482	sulfurtransferase activity
MCU78_RS09515	COG2860	membrane
MCU78_RS09520	COG4608	Belongs to the ABC transporter superfamily
MCU78_RS09525	COG0444	Belongs to the ABC transporter superfamily
MCU78_RS09535	COG4166	transmembrane transport
MCU78_RS09565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MCU78_RS09570	COG0509	glycine decarboxylation via glycine cleavage system
MCU78_RS09575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MCU78_RS09580	COG1760	l-serine dehydratase
MCU78_RS09655	COG1376	ErfK ybiS ycfS ynhG family protein
MCU78_RS09665	COG1132	(ABC) transporter
MCU78_RS09670	COG1132	(ABC) transporter
MCU78_RS09690	COG0058	SHG alpha-glucan phosphorylase activity
MCU78_RS09700	COG0366	Alpha amylase catalytic
MCU78_RS09705	COG0366	Alpha amylase catalytic
MCU78_RS09710	COG3281	Trehalose synthase
MCU78_RS09715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MCU78_RS09765	COG1051	belongs to the nudix hydrolase family
MCU78_RS09770	COG0477	Major facilitator Superfamily
MCU78_RS09780	COG1301	dicarboxylic acid transport
MCU78_RS09785	COG3290	protein histidine kinase activity
MCU78_RS09790	COG4565	transcriptional regulatory protein
MCU78_RS09800	COG1175	transmembrane transport
MCU78_RS09805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCU78_RS09835	COG0395	ABC-type sugar transport system, permease component
MCU78_RS09840	COG1136	(ABC) transporter
MCU78_RS09845	COG0577	efflux transmembrane transporter activity
MCU78_RS09845	COG1136	(ABC) transporter
MCU78_RS09850	COG2084	Dehydrogenase
MCU78_RS09855	COG0205	6-phosphofructokinase activity
MCU78_RS09860	COG0857	belongs to the CobB CobQ family
MCU78_RS09860	COG0280	phosphate acetyltransferase
MCU78_RS09865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MCU78_RS09905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCU78_RS09905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCU78_RS09955	COG0183	Belongs to the thiolase family
MCU78_RS10015	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MCU78_RS10030	COG1250	3-hydroxyacyl-CoA dehydrogenase
MCU78_RS10050	COG2197	response regulator
MCU78_RS10065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MCU78_RS10070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MCU78_RS10075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MCU78_RS10080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MCU78_RS10085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MCU78_RS10090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MCU78_RS10095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MCU78_RS10110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MCU78_RS10115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MCU78_RS10120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MCU78_RS10130	COG2890	protein-(glutamine-N5) methyltransferase activity
MCU78_RS10135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MCU78_RS10140	COG0254	rRNA binding
MCU78_RS10155	COG0083	homoserine kinase activity
MCU78_RS10160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MCU78_RS10165	COG0460	homoserine dehydrogenase
MCU78_RS10170	COG0019	diaminopimelate decarboxylase activity
MCU78_RS10175	COG0018	arginyl-trna synthetase
MCU78_RS10175	COG0018	arginyl-trna synthetase
MCU78_RS10180	COG0745	RESPONSE REGULATOR receiver
MCU78_RS10200	COG1686	Belongs to the peptidase S11 family
MCU78_RS10205	COG0768	penicillin binding
MCU78_RS10295	COG1280	lysine exporter protein (LysE YggA)
MCU78_RS10310	COG2188	Transcriptional regulator
MCU78_RS10335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MCU78_RS10340	COG2207	Transcriptional regulator
MCU78_RS10340	COG3708	Transcriptional regulator
MCU78_RS10360	COG0745	RESPONSE REGULATOR receiver
MCU78_RS10365	COG2205	protein histidine kinase activity
MCU78_RS10370	COG0567	Dehydrogenase, E1 component
MCU78_RS10370	COG0508	dehydrogenase complex catalyzes the overall conversion of
MCU78_RS10450	COG0604	alcohol dehydrogenase
MCU78_RS10455	COG0281	malic enzyme
MCU78_RS10465	COG0765	amino acid transport
MCU78_RS10470	COG1126	abc transporter atp-binding protein
MCU78_RS10500	COG0583	DNA-binding transcription factor activity
MCU78_RS10505	COG2814	Major facilitator Superfamily
MCU78_RS10510	COG0697	spore germination
MCU78_RS10515	COG1846	Transcriptional regulator
MCU78_RS10530	COG0640	Transcriptional regulator
MCU78_RS10545	COG1316	TRANSCRIPTIONal
MCU78_RS10560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MCU78_RS10580	COG2066	Belongs to the glutaminase family
MCU78_RS10625	COG1597	lipid kinase activity
MCU78_RS10640	COG1309	transcriptional regulator
MCU78_RS10645	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS10650	COG0363	glucosamine-6-phosphate deaminase activity
MCU78_RS10655	COG1472	Belongs to the glycosyl hydrolase 3 family
MCU78_RS10660	COG0395	ABC-type sugar transport system, permease component
MCU78_RS10665	COG1175	transmembrane transport
MCU78_RS10670	COG2182	Extracellular solute-binding protein
MCU78_RS10675	COG2188	Transcriptional regulator
MCU78_RS10690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MCU78_RS10705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MCU78_RS10715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MCU78_RS10725	COG0242	peptide deformylase activity
MCU78_RS10745	COG5662	AntiSigma factor
MCU78_RS10750	COG1595	DNA-templated transcription, initiation
MCU78_RS10760	COG2135	peptidase activity
MCU78_RS10770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MCU78_RS10775	COG1162	GTPase activity
MCU78_RS10780	COG2076	Multidrug Resistance protein
MCU78_RS10790	COG0483	inositol monophosphate 1-phosphatase activity
MCU78_RS10800	COG0753	catalase activity
MCU78_RS10825	COG1615	UPF0182 protein
MCU78_RS10835	COG3480	Lon protease (S16) C-terminal proteolytic domain
MCU78_RS10870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MCU78_RS10910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCU78_RS10915	COG0210	DNA helicase
MCU78_RS10920	COG0210	DNA helicase
MCU78_RS10955	COG3842	ATPase activity
MCU78_RS10960	COG0596	Alpha beta hydrolase
MCU78_RS10980	COG0640	Transcriptional regulator
MCU78_RS10985	COG1609	Transcriptional regulator
MCU78_RS11030	COG4172	Belongs to the ABC transporter superfamily
MCU78_RS11040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCU78_RS11045	COG0747	negative chemotaxis
MCU78_RS11085	COG0513	Belongs to the DEAD box helicase family
MCU78_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS11095	COG0596	Alpha beta hydrolase
MCU78_RS11105	COG1432	Conserved Protein
MCU78_RS11115	COG2095	MarC family integral membrane protein
MCU78_RS11135	COG0598	Magnesium transport protein CorA
MCU78_RS11175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MCU78_RS11180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCU78_RS11190	COG1595	DNA-templated transcription, initiation
MCU78_RS11205	COG1024	Enoyl-CoA hydratase
MCU78_RS11210	COG0519	Catalyzes the synthesis of GMP from XMP
MCU78_RS11220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MCU78_RS11230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCU78_RS11265	COG2197	response regulator
MCU78_RS11270	COG4585	Histidine kinase
MCU78_RS11280	COG1131	(ABC) transporter
MCU78_RS11295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MCU78_RS11310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCU78_RS11315	COG0747	negative chemotaxis
MCU78_RS11325	COG0444	Belongs to the ABC transporter superfamily
MCU78_RS11330	COG4608	Belongs to the ABC transporter superfamily
MCU78_RS11340	COG1595	DNA-templated transcription, initiation
MCU78_RS11345	COG4608	Belongs to the ABC transporter superfamily
MCU78_RS11355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCU78_RS11360	COG0601	transmembrane transport
MCU78_RS11365	COG4166	transmembrane transport
MCU78_RS11390	COG4608	Belongs to the ABC transporter superfamily
MCU78_RS11400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCU78_RS11405	COG0601	transmembrane transport
MCU78_RS11415	COG1217	gtp-binding protein TYPA
MCU78_RS11465	COG0531	amino acid
MCU78_RS11495	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MCU78_RS11525	COG0012	GTP binding
MCU78_RS11540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MCU78_RS11550	COG1570	exodeoxyribonuclease VII activity
MCU78_RS11555	COG1722	exodeoxyribonuclease VII activity
MCU78_RS11560	COG0778	Nitroreductase
MCU78_RS11585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MCU78_RS11585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MCU78_RS11595	COG0114	fumarate hydratase activity
MCU78_RS11620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCU78_RS11640	COG1136	(ABC) transporter
MCU78_RS11660	COG0450	alkyl hydroperoxide reductase
MCU78_RS11665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MCU78_RS11680	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MCU78_RS11685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MCU78_RS11690	COG0667	Aldo Keto reductase
MCU78_RS11715	COG2885	chlorophyll binding
MCU78_RS11755	COG2894	cell division
MCU78_RS11790	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MCU78_RS11805	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MCU78_RS11815	COG0477	Major facilitator Superfamily
MCU78_RS11825	COG1331	Highly conserved protein containing a thioredoxin domain
MCU78_RS11830	COG2255	four-way junction helicase activity
MCU78_RS11840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MCU78_RS11850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCU78_RS11865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MCU78_RS11885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCU78_RS11895	COG1819	glycosyl
MCU78_RS11925	COG0531	amino acid
MCU78_RS11940	COG1376	ErfK ybiS ycfS ynhG family protein
MCU78_RS11950	COG2986	histidine ammonia-lyase
MCU78_RS11960	COG1024	Enoyl-CoA hydratase
MCU78_RS11965	COG0328	RNA-DNA hybrid ribonuclease activity
MCU78_RS11970	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MCU78_RS11980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MCU78_RS11990	COG0768	penicillin binding
MCU78_RS11995	COG0424	maF-like protein
MCU78_RS12005	COG4770	biotin carboxylase activity
MCU78_RS12045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCU78_RS12095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MCU78_RS12100	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS12105	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS12120	COG1595	DNA-templated transcription, initiation
MCU78_RS12125	COG0745	RESPONSE REGULATOR receiver
MCU78_RS12130	COG2205	protein histidine kinase activity
MCU78_RS12155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MCU78_RS12165	COG0583	DNA-binding transcription factor activity
MCU78_RS12170	COG2814	Major facilitator Superfamily
MCU78_RS12185	COG1079	Belongs to the binding-protein-dependent transport system permease family
MCU78_RS12190	COG4603	Belongs to the binding-protein-dependent transport system permease family
MCU78_RS12195	COG3845	ABC transporter
MCU78_RS12200	COG1744	ABC transporter substrate-binding protein PnrA-like
MCU78_RS12205	COG1473	amidohydrolase
MCU78_RS12205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MCU78_RS12215	COG2089	acid synthase
MCU78_RS12230	COG1216	Glycosyl transferase, family 2
MCU78_RS12240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MCU78_RS12260	COG3265	gluconokinase activity
MCU78_RS12265	COG2186	Transcriptional regulator
MCU78_RS12305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCU78_RS12305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCU78_RS12315	COG1595	DNA-templated transcription, initiation
MCU78_RS12335	COG2009	succinate dehydrogenase
MCU78_RS12345	COG1053	succinate dehydrogenase
MCU78_RS12355	COG2826	transposase and inactivated derivatives, IS30 family
MCU78_RS12365	COG0667	Aldo Keto reductase
MCU78_RS12375	COG0747	negative chemotaxis
MCU78_RS12385	COG1686	Belongs to the peptidase S11 family
MCU78_RS12390	COG1295	ribonuclease BN
MCU78_RS12400	COG0180	Tryptophanyl-tRNA synthetase
MCU78_RS12405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCU78_RS12410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCU78_RS12445	COG0754	glutathionylspermidine amidase activity
MCU78_RS12455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCU78_RS12460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MCU78_RS12480	COG4176	ABC-type proline glycine betaine transport system permease component
MCU78_RS12485	COG0517	IMP dehydrogenase activity
MCU78_RS12485	COG4175	Glycine betaine
MCU78_RS12495	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS12560	COG0039	L-malate dehydrogenase activity
MCU78_RS12585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MCU78_RS12595	COG0138	bifunctional purine biosynthesis protein purh
MCU78_RS12625	COG0045	succinate-CoA ligase (ADP-forming) activity
MCU78_RS12630	COG3552	Protein containing von Willebrand factor type A (VWA) domain
MCU78_RS12640	COG0714	Associated with various cellular activities
MCU78_RS12655	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCU78_RS12655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MCU78_RS12660	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MCU78_RS12665	COG0739	heme binding
MCU78_RS12690	COG2197	response regulator
MCU78_RS12700	COG0515	serine threonine protein kinase
MCU78_RS12700	COG2815	serine threonine protein kinase
MCU78_RS12720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MCU78_RS12720	COG0519	Catalyzes the synthesis of GMP from XMP
MCU78_RS12735	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS12740	COG0515	serine threonine protein kinase
MCU78_RS12740	COG2815	serine threonine protein kinase
MCU78_RS12775	COG1366	Belongs to the anti-sigma-factor antagonist family
MCU78_RS12815	COG1131	(ABC) transporter
MCU78_RS12830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCU78_RS12835	COG0596	Alpha beta hydrolase
MCU78_RS12835	COG2945	thiolester hydrolase activity
MCU78_RS12845	COG4821	SIS domain
MCU78_RS12855	COG0259	pyridoxamine-phosphate oxidase activity
MCU78_RS12870	COG1024	Enoyl-CoA hydratase
MCU78_RS12885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MCU78_RS12920	COG3548	integral membrane protein
MCU78_RS12930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MCU78_RS12950	COG2814	Major facilitator Superfamily
MCU78_RS12960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MCU78_RS12965	COG2318	DinB family
MCU78_RS12970	COG1113	amino acid transport
MCU78_RS12980	COG2076	Multidrug Resistance protein
MCU78_RS12995	COG2890	protein-(glutamine-N5) methyltransferase activity
MCU78_RS13015	COG1595	DNA-templated transcription, initiation
MCU78_RS13020	COG0640	Transcriptional regulator
MCU78_RS13025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MCU78_RS13030	COG1215	transferase activity, transferring glycosyl groups
MCU78_RS13035	COG0667	Aldo Keto reductase
MCU78_RS13070	COG2252	PERMEase
MCU78_RS13080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MCU78_RS13095	COG0702	epimerase
MCU78_RS13125	COG2814	Major facilitator Superfamily
MCU78_RS13135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MCU78_RS13140	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MCU78_RS13160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS13165	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS13170	COG1120	ATPase activity
MCU78_RS13235	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MCU78_RS13250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MCU78_RS13255	COG1061	Type III restriction enzyme res subunit
MCU78_RS13275	COG3973	AAA domain
MCU78_RS13290	COG2814	Major facilitator Superfamily
MCU78_RS13320	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MCU78_RS13355	COG1263	PTS System
MCU78_RS13355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MCU78_RS13365	COG1278	Cold shock
MCU78_RS13380	COG0463	Glycosyl transferase, family 2
MCU78_RS13385	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MCU78_RS13410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MCU78_RS13415	COG1846	Transcriptional regulator
MCU78_RS13415	COG1940	carbohydrate kinase activity
MCU78_RS13425	COG1105	Belongs to the carbohydrate kinase PfkB family
MCU78_RS13485	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MCU78_RS13500	COG4941	Belongs to the sigma-70 factor family
MCU78_RS13510	COG4585	Histidine kinase
MCU78_RS13515	COG2409	Drug exporters of the RND superfamily
MCU78_RS13555	COG2409	Drug exporters of the RND superfamily
MCU78_RS13565	COG3842	ATPase activity
MCU78_RS13575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MCU78_RS13585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCU78_RS13590	COG0215	cysteine-tRNA ligase activity
MCU78_RS13600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MCU78_RS13605	COG3467	pyridoxamine 5'-phosphate
MCU78_RS13610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MCU78_RS13615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MCU78_RS13620	COG1329	Transcriptional regulator
MCU78_RS13635	COG5002	protein histidine kinase activity
MCU78_RS13645	COG0588	phosphoglycerate mutase activity
MCU78_RS13660	COG0438	transferase activity, transferring glycosyl groups
MCU78_RS13670	COG0406	alpha-ribazole phosphatase activity
MCU78_RS13670	COG0494	nUDIX hydrolase
MCU78_RS13690	COG1131	(ABC) transporter
MCU78_RS13695	COG1725	Transcriptional regulator
MCU78_RS13700	COG0454	-acetyltransferase
MCU78_RS13700	COG0456	acetyltransferase
MCU78_RS13705	COG0737	Belongs to the 5'-nucleotidase family
MCU78_RS13725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCU78_RS13735	COG1609	Transcriptional regulator
MCU78_RS13740	COG0745	RESPONSE REGULATOR receiver
MCU78_RS13775	COG2897	thiosulfate sulfurtransferase activity
MCU78_RS13795	COG3485	protocatechuate 3,4-dioxygenase
MCU78_RS13800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS13805	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MCU78_RS13825	COG1490	D-aminoacyl-tRNA deacylase activity
MCU78_RS13840	COG4552	Acetyltransferase involved in intracellular survival and related
MCU78_RS13845	COG0431	NADPH-dependent FMN reductase
MCU78_RS13850	COG1733	regulation of RNA biosynthetic process
MCU78_RS13870	COG0477	Major facilitator Superfamily
MCU78_RS13900	COG0667	Aldo Keto reductase
MCU78_RS13965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MCU78_RS13980	COG1937	Protein conserved in bacteria
MCU78_RS14000	COG0277	FAD linked oxidase domain protein
MCU78_RS14010	COG0671	phosphoesterase, PA-phosphatase related
MCU78_RS14015	COG0791	NLP P60 protein
MCU78_RS14060	COG0515	serine threonine protein kinase
MCU78_RS14060	COG2815	serine threonine protein kinase
MCU78_RS14105	COG2197	response regulator
MCU78_RS14110	COG4585	Histidine kinase
MCU78_RS14115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MCU78_RS14155	COG0129	dihydroxy-acid dehydratase activity
MCU78_RS14165	COG1082	Xylose isomerase domain protein TIM barrel
MCU78_RS14170	COG0248	Ppx GppA phosphatase
MCU78_RS14190	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MCU78_RS14215	COG1595	DNA-templated transcription, initiation
MCU78_RS14225	COG0745	RESPONSE REGULATOR receiver
MCU78_RS14230	COG2205	protein histidine kinase activity
MCU78_RS14240	COG0739	heme binding
MCU78_RS14240	COG0741	lytic transglycosylase activity
MCU78_RS14240	COG1196	nuclear chromosome segregation
MCU78_RS14270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MCU78_RS14290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MCU78_RS14300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MCU78_RS14305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MCU78_RS14325	COG0583	DNA-binding transcription factor activity
MCU78_RS14350	COG0649	NAD binding
MCU78_RS14365	COG1174	glycine betaine transport
MCU78_RS14370	COG1174	glycine betaine transport
MCU78_RS14385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MCU78_RS14390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MCU78_RS14405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MCU78_RS14405	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MCU78_RS14415	COG0302	gtp cyclohydrolase
MCU78_RS14430	COG0037	tRNA processing
MCU78_RS14440	COG2027	D-alanyl-D-alanine carboxypeptidase
MCU78_RS14445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MCU78_RS14455	COG0586	Pfam SNARE associated Golgi protein
MCU78_RS14460	COG0393	Putative heavy-metal-binding
MCU78_RS14480	COG2318	DinB family
MCU78_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS14515	COG1077	Cell shape determining protein MreB Mrl
MCU78_RS14560	COG1595	DNA-templated transcription, initiation
MCU78_RS14615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCU78_RS14625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCU78_RS14640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS14665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCU78_RS14670	COG0386	Belongs to the glutathione peroxidase family
MCU78_RS14685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS14700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCU78_RS14730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCU78_RS14735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCU78_RS14750	COG0477	Major facilitator Superfamily
MCU78_RS14755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MCU78_RS14775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCU78_RS14810	COG0475	glutathione-regulated potassium exporter activity
MCU78_RS14860	COG2226	methyltransferase
MCU78_RS14875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCU78_RS14895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MCU78_RS14970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MCU78_RS14975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MCU78_RS14980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MCU78_RS14980	COG1754	DNA topoisomerase type I activity
MCU78_RS15000	COG2890	protein-(glutamine-N5) methyltransferase activity
MCU78_RS15010	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MCU78_RS15015	COG2172	sigma factor antagonist activity
MCU78_RS15020	COG1366	Belongs to the anti-sigma-factor antagonist family
MCU78_RS15025	COG1205	dead DEAH box helicase
MCU78_RS15025	COG1111	helicase
MCU78_RS15090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCU78_RS15095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MCU78_RS15105	COG2267	carboxylic ester hydrolase activity
MCU78_RS15135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCU78_RS15160	COG0003	Pfam Anion-transporting ATPase
MCU78_RS15170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCU78_RS15180	COG1408	metallophosphoesterase
MCU78_RS15195	COG3850	Histidine kinase
MCU78_RS15200	COG2197	response regulator
MCU78_RS15210	COG3479	Phenolic acid decarboxylase
MCU78_RS15235	COG1595	DNA-templated transcription, initiation
MCU78_RS15265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MCU78_RS15270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MCU78_RS15305	COG2208	phosphoserine phosphatase activity
MCU78_RS15305	COG2770	Histidine kinase
MCU78_RS15350	COG0789	Transcriptional regulator
MCU78_RS15380	COG0583	DNA-binding transcription factor activity
MCU78_RS15385	COG0596	Alpha beta hydrolase
MCU78_RS15390	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS15410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MCU78_RS15470	COG1191	sigma factor activity
MCU78_RS15475	COG1191	sigma factor activity
MCU78_RS15485	COG1846	Transcriptional regulator
MCU78_RS15500	COG0477	Major facilitator Superfamily
MCU78_RS15545	COG1309	transcriptional regulator
MCU78_RS15550	COG2814	Major facilitator Superfamily
MCU78_RS15555	COG0318	PFAM AMP-dependent synthetase and ligase
MCU78_RS15560	COG1595	DNA-templated transcription, initiation
MCU78_RS15600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCU78_RS15615	COG0653	protein targeting
MCU78_RS15635	COG0006	proline dipeptidase activity
MCU78_RS15650	COG3795	YCII-related domain
MCU78_RS15655	COG4941	Belongs to the sigma-70 factor family
MCU78_RS15685	COG2372	response to copper ion
MCU78_RS15690	COG2837	iron assimilation
MCU78_RS15700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MCU78_RS15705	COG0561	phosphatase activity
MCU78_RS15745	COG2807	transmembrane transport
MCU78_RS15775	COG1215	transferase activity, transferring glycosyl groups
MCU78_RS15800	COG1131	(ABC) transporter
MCU78_RS15820	COG0789	Transcriptional regulator
MCU78_RS15830	COG0501	Belongs to the peptidase M48B family
MCU78_RS15850	COG0561	phosphatase activity
MCU78_RS15870	COG4988	ABC transporter
MCU78_RS15875	COG1294	oxidase, subunit
MCU78_RS15880	COG1271	oxidase subunit
MCU78_RS15885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCU78_RS15890	COG1609	Transcriptional regulator
MCU78_RS15895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MCU78_RS15905	COG2304	oxidoreductase activity
MCU78_RS15930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MCU78_RS15945	COG2268	Band 7 protein
MCU78_RS15960	COG0662	Cupin 2, conserved barrel domain protein
MCU78_RS15965	COG1950	PFAM Membrane protein of
MCU78_RS15980	COG2816	NAD+ diphosphatase activity
MCU78_RS16005	COG2814	Major facilitator Superfamily
MCU78_RS16040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MCU78_RS16055	COG3118	belongs to the thioredoxin family
MCU78_RS16055	COG0492	ferredoxin-NADP+ reductase activity
MCU78_RS16060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MCU78_RS16070	COG0789	Transcriptional regulator
MCU78_RS16070	COG4978	Transcriptional regulator
MCU78_RS16080	COG0697	spore germination
MCU78_RS16085	COG2910	NAD(P)H-binding
MCU78_RS16095	COG1309	transcriptional regulator
MCU78_RS16115	COG0305	Participates in initiation and elongation during chromosome replication
MCU78_RS16125	COG0359	binds to the 23S rRNA
MCU78_RS16130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MCU78_RS16135	COG0629	single-stranded DNA binding
MCU78_RS16140	COG0360	Binds together with S18 to 16S ribosomal RNA
MCU78_RS16165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCU78_RS16175	COG1260	myo-inositol-1-phosphate synthase
MCU78_RS16185	COG0617	tRNA 3'-terminal CCA addition
MCU78_RS16205	COG1595	DNA-templated transcription, initiation
MCU78_RS16215	COG0492	ferredoxin-NADP+ reductase activity
MCU78_RS16220	COG3118	belongs to the thioredoxin family
MCU78_RS16235	COG1192	Involved in chromosome partitioning
MCU78_RS16240	COG0357	Ribosomal RNA small subunit methyltransferase G
MCU78_RS16250	COG0706	membrane insertase activity
MCU78_RS16255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MCU78_RS16265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MCU78_RS16275	COG0592	DNA-directed DNA polymerase activity
MCU78_RS16280	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MCU78_RS16285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MCU78_RS16290	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MCU78_RS16295	COG0187	DNA topoisomerase II activity
MCU78_RS16300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MCU78_RS16305	COG3266	domain, Protein
MCU78_RS16320	COG0515	serine threonine protein kinase
MCU78_RS16345	COG0705	Rhomboid family
MCU78_RS16370	COG3764	Sortase (surface protein transpeptidase)
MCU78_RS16375	COG3764	Sortase (surface protein transpeptidase)
MCU78_RS16380	COG0515	serine threonine protein kinase
MCU78_RS16385	COG0768	penicillin binding
MCU78_RS16400	COG1716	ATPase activity
MCU78_RS16405	COG1716	ATPase activity
MCU78_RS16430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCU78_RS16435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MCU78_RS16440	COG2151	metal-sulfur cluster biosynthetic enzyme
MCU78_RS16445	COG3396	Phenylacetate-CoA oxygenase
MCU78_RS16450	COG3460	Phenylacetate-CoA oxygenase
MCU78_RS16455	COG3396	Phenylacetate-CoA oxygenase
MCU78_RS16480	COG1250	3-hydroxyacyl-CoA dehydrogenase
MCU78_RS16485	COG1309	transcriptional regulator
MCU78_RS16490	COG1522	sequence-specific DNA binding
MCU78_RS16500	COG0022	dehydrogenase e1 component
MCU78_RS16550	COG0515	serine threonine protein kinase
MCU78_RS16555	COG0515	serine threonine protein kinase
MCU78_RS16580	COG0022	dehydrogenase e1 component
MCU78_RS16585	COG0508	dehydrogenase complex catalyzes the overall conversion of
MCU78_RS16665	COG1362	aminopeptidase activity
MCU78_RS16670	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS16685	COG1741	Belongs to the pirin family
MCU78_RS16695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MCU78_RS16705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCU78_RS16790	COG1278	Cold shock
MCU78_RS16800	COG4585	Histidine kinase
MCU78_RS16805	COG2197	response regulator
MCU78_RS16810	COG3655	Transcriptional regulator
MCU78_RS16855	COG2188	Transcriptional regulator
MCU78_RS16880	COG2188	Transcriptional regulator
MCU78_RS16960	COG0717	Belongs to the dCTP deaminase family
MCU78_RS16990	COG2181	nitrate reductase activity
MCU78_RS16990	COG0247	lactate metabolic process
MCU78_RS16995	COG0443	Heat shock 70 kDa protein
MCU78_RS17000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MCU78_RS17005	COG0484	heat shock protein binding
MCU78_RS17010	COG0789	Transcriptional regulator
MCU78_RS17020	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS17025	COG0583	DNA-binding transcription factor activity
MCU78_RS17045	COG0542	response to heat
MCU78_RS17070	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MCU78_RS17100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MCU78_RS17110	COG0477	Major facilitator Superfamily
MCU78_RS17120	COG3483	tryptophan 2,3-dioxygenase activity
MCU78_RS17125	COG3844	kynureninase activity
MCU78_RS17135	COG4585	Histidine kinase
MCU78_RS17140	COG2197	response regulator
MCU78_RS17150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MCU78_RS17160	COG1278	Cold shock
MCU78_RS17165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MCU78_RS17170	COG1802	Transcriptional regulator
MCU78_RS17175	COG0463	Glycosyl transferase, family 2
MCU78_RS17190	COG0151	Belongs to the GarS family
MCU78_RS17205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MCU78_RS17210	COG0745	RESPONSE REGULATOR receiver
MCU78_RS17225	COG2197	response regulator
MCU78_RS17260	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MCU78_RS17265	COG0047	phosphoribosylformylglycinamidine synthase activity
MCU78_RS17270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MCU78_RS17295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MCU78_RS17330	COG1643	Atp-dependent helicase
MCU78_RS17360	COG0513	Belongs to the DEAD box helicase family
MCU78_RS17385	COG1278	Cold shock
MCU78_RS17390	COG0513	Belongs to the DEAD box helicase family
MCU78_RS17405	COG2271	Major facilitator Superfamily
MCU78_RS17410	COG0667	Aldo Keto reductase
MCU78_RS17460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MCU78_RS17465	COG0579	oxidoreductase
MCU78_RS17480	COG0366	Alpha amylase catalytic
MCU78_RS17480	COG1470	cell adhesion involved in biofilm formation
MCU78_RS17530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MCU78_RS17535	COG0180	Tryptophanyl-tRNA synthetase
MCU78_RS17555	COG0123	including yeast histone deacetylase and acetoin utilization protein
MCU78_RS17605	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MCU78_RS17610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MCU78_RS17615	COG0181	hydroxymethylbilane synthase activity
MCU78_RS17620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MCU78_RS17620	COG1648	precorrin-2 dehydrogenase activity
MCU78_RS17625	COG0113	porphobilinogen synthase activity
MCU78_RS17635	COG0018	arginyl-trna synthetase
MCU78_RS17640	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MCU78_RS17655	COG1690	Belongs to the RtcB family
MCU78_RS17680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MCU78_RS17685	COG0406	alpha-ribazole phosphatase activity
MCU78_RS17700	COG0785	Cytochrome C biogenesis protein
MCU78_RS17705	COG1333	cytochrome c biogenesis protein
MCU78_RS17710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MCU78_RS17735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MCU78_RS17750	COG0163	prenyltransferase activity
MCU78_RS17765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MCU78_RS17780	COG1301	dicarboxylic acid transport
MCU78_RS17815	COG1309	transcriptional regulator
MCU78_RS17835	COG1278	Cold shock
MCU78_RS17840	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MCU78_RS17845	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MCU78_RS17850	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MCU78_RS17860	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MCU78_RS17880	COG2226	methyltransferase
MCU78_RS17895	COG2226	methyltransferase
MCU78_RS17905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS17915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MCU78_RS17925	COG1073	alpha beta
MCU78_RS17940	COG0477	Major facilitator Superfamily
MCU78_RS17985	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCU78_RS17990	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCU78_RS17995	COG0649	NAD binding
MCU78_RS18005	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MCU78_RS18010	COG1034	ATP synthesis coupled electron transport
MCU78_RS18015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MCU78_RS18020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCU78_RS18025	COG0839	Belongs to the complex I subunit 6 family
MCU78_RS18030	COG0713	ATP synthesis coupled electron transport
MCU78_RS18035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MCU78_RS18045	COG1007	ATP synthesis coupled electron transport
MCU78_RS18060	COG0492	ferredoxin-NADP+ reductase activity
MCU78_RS18065	COG0142	geranyltranstransferase activity
MCU78_RS18085	COG2234	aminopeptidase activity
MCU78_RS18085	COG4935	Belongs to the peptidase S8 family
MCU78_RS18095	COG0531	amino acid
MCU78_RS18100	COG1013	pyruvate-flavodoxin oxidoreductase activity
MCU78_RS18105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MCU78_RS18105	COG0674	pyruvate-flavodoxin oxidoreductase activity
MCU78_RS18125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCU78_RS18130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCU78_RS18145	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MCU78_RS18150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCU78_RS18155	COG0839	Belongs to the complex I subunit 6 family
MCU78_RS18160	COG0713	ATP synthesis coupled electron transport
MCU78_RS18165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MCU78_RS18175	COG1007	ATP synthesis coupled electron transport
MCU78_RS18180	COG0501	Belongs to the peptidase M48B family
MCU78_RS18200	COG0583	DNA-binding transcription factor activity
MCU78_RS18210	COG3304	Inner membrane component domain
MCU78_RS18225	COG1666	GTP binding
MCU78_RS18235	COG0702	epimerase
MCU78_RS18255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MCU78_RS18260	COG2030	dehydratase
MCU78_RS18280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MCU78_RS18285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MCU78_RS18290	COG0436	Aminotransferase
MCU78_RS18305	COG0250	Participates in transcription elongation, termination and antitermination
MCU78_RS18310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MCU78_RS18315	COG0081	regulation of translation
MCU78_RS18335	COG0222	ribosome binding
MCU78_RS18340	COG0085	RNA polymerase activity
MCU78_RS18345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MCU78_RS18475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MCU78_RS18480	COG0049	tRNA binding
MCU78_RS18485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MCU78_RS18510	COG0051	transcription antitermination factor activity, RNA binding
MCU78_RS18515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MCU78_RS18520	COG0088	Forms part of the polypeptide exit tunnel
MCU78_RS18525	COG0089	rRNA binding
MCU78_RS18530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MCU78_RS18535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MCU78_RS18540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MCU78_RS18545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MCU78_RS18550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MCU78_RS18555	COG0255	Belongs to the universal ribosomal protein uL29 family
MCU78_RS18560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MCU78_RS18565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MCU78_RS18570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MCU78_RS18575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MCU78_RS18580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MCU78_RS18585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MCU78_RS18590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MCU78_RS18595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MCU78_RS18600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MCU78_RS18605	COG1841	ribosomal large subunit assembly
MCU78_RS18610	COG0200	Binds to the 23S rRNA
MCU78_RS18620	COG0563	adenylate kinase activity
MCU78_RS18630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MCU78_RS18635	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MCU78_RS18640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MCU78_RS18645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MCU78_RS18655	COG0203	ribosomal protein L17
MCU78_RS18660	COG0101	tRNA pseudouridine synthase activity
MCU78_RS18675	COG0488	(ABC) transporter
MCU78_RS18680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MCU78_RS18685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MCU78_RS18690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCU78_RS18695	COG1072	(Pantothenic acid kinase))
MCU78_RS18705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MCU78_RS18710	COG0736	holo-[acyl-carrier-protein] synthase activity
MCU78_RS18740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MCU78_RS18750	COG0802	atpase or kinase
MCU78_RS18785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MCU78_RS18810	COG0726	polysaccharide deacetylase
MCU78_RS18825	COG4221	oxidoreductase activity
MCU78_RS18835	COG0583	DNA-binding transcription factor activity
MCU78_RS18845	COG2197	response regulator
MCU78_RS18850	COG1595	DNA-templated transcription, initiation
MCU78_RS18860	COG0516	GMP reductase activity
MCU78_RS18865	COG1077	Cell shape determining protein MreB Mrl
MCU78_RS18875	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MCU78_RS18910	COG1309	transcriptional regulator
MCU78_RS18920	COG0515	serine threonine protein kinase
MCU78_RS18920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCU78_RS19000	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MCU78_RS19025	COG1686	Belongs to the peptidase S11 family
MCU78_RS19050	COG0514	ATP-dependent DNA helicase (RecQ)
MCU78_RS19065	COG2124	cytochrome p450
MCU78_RS19130	COG2188	Transcriptional regulator
MCU78_RS19170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCU78_RS19170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCU78_RS19185	COG4977	sequence-specific DNA binding
MCU78_RS19220	COG1846	Transcriptional regulator
MCU78_RS19225	COG3384	dioxygenase
MCU78_RS19250	COG0477	Major facilitator Superfamily
MCU78_RS19260	COG1349	DNA-binding transcription factor activity
MCU78_RS19290	COG1970	mechanosensitive ion channel activity
MCU78_RS19295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MCU78_RS19310	COG3263	regulation of cellular component size
MCU78_RS19320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MCU78_RS19325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MCU78_RS19335	COG0315	cyclic pyranopterin monophosphate synthase activity
MCU78_RS19340	COG0315	cyclic pyranopterin monophosphate synthase activity
MCU78_RS19340	COG0521	Mo-molybdopterin cofactor biosynthetic process
MCU78_RS19345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCU78_RS19395	COG0659	secondary active sulfate transmembrane transporter activity
MCU78_RS19420	COG2205	protein histidine kinase activity
MCU78_RS19425	COG0596	Alpha beta hydrolase
MCU78_RS19435	COG0708	Exodeoxyribonuclease III
MCU78_RS19445	COG2072	flavoprotein involved in K transport
MCU78_RS19460	COG0793	Belongs to the peptidase S41A family
MCU78_RS19460	COG4946	Tricorn protease homolog
MCU78_RS19470	COG2409	Drug exporters of the RND superfamily
MCU78_RS19490	COG1122	ATPase activity
MCU78_RS19530	COG0084	hydrolase, TatD family'
MCU78_RS19535	COG3583	domain protein
MCU78_RS19535	COG3584	3D domain protein
MCU78_RS19540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MCU78_RS19545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MCU78_RS19555	COG0488	(ABC) transporter
MCU78_RS19580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MCU78_RS19590	COG2197	response regulator
MCU78_RS19595	COG1846	Transcriptional regulator
MCU78_RS19600	COG4106	trans-aconitate 2-methyltransferase activity
MCU78_RS19610	COG1309	transcriptional regulator
MCU78_RS19620	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MCU78_RS19625	COG0193	aminoacyl-tRNA hydrolase activity
MCU78_RS19630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MCU78_RS19635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MCU78_RS19640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MCU78_RS19655	COG4585	Histidine kinase
MCU78_RS19690	COG1136	(ABC) transporter
MCU78_RS19695	COG0577	efflux transmembrane transporter activity
MCU78_RS19725	COG0515	serine threonine protein kinase
MCU78_RS19725	COG2815	serine threonine protein kinase
MCU78_RS19745	COG2124	cytochrome p450
MCU78_RS19750	COG1652	LysM domain
MCU78_RS19760	COG0148	phosphopyruvate hydratase activity
MCU78_RS19780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCU78_RS19800	COG1252	NADH dehydrogenase
MCU78_RS19805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MCU78_RS19810	COG0577	efflux transmembrane transporter activity
MCU78_RS19815	COG1136	(ABC) transporter
MCU78_RS19830	COG0179	Fumarylacetoacetate (FAA) hydrolase
MCU78_RS19840	COG0318	PFAM AMP-dependent synthetase and ligase
MCU78_RS19845	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MCU78_RS19875	COG0604	alcohol dehydrogenase
MCU78_RS19900	COG0183	Belongs to the thiolase family
MCU78_RS19905	COG2755	lipolytic protein G-D-S-L family
MCU78_RS19920	COG0318	PFAM AMP-dependent synthetase and ligase
MCU78_RS19945	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MCU78_RS19960	COG1228	amidohydrolase
MCU78_RS19970	COG1794	racemase activity, acting on amino acids and derivatives
MCU78_RS19975	COG1191	sigma factor activity
MCU78_RS19980	COG1366	Belongs to the anti-sigma-factor antagonist family
MCU78_RS19990	COG3104	oligopeptide transport
MCU78_RS19995	COG0745	RESPONSE REGULATOR receiver
MCU78_RS20000	COG2205	protein histidine kinase activity
MCU78_RS20025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MCU78_RS20085	COG1316	TRANSCRIPTIONal
MCU78_RS20090	COG1607	acyl-coa hydrolase
MCU78_RS20095	COG1316	TRANSCRIPTIONal
MCU78_RS20105	COG1316	TRANSCRIPTIONal
MCU78_RS20110	COG1316	TRANSCRIPTIONal
MCU78_RS20140	COG0778	Nitroreductase
MCU78_RS20140	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MCU78_RS20145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MCU78_RS20180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCU78_RS20195	COG1482	cell wall glycoprotein biosynthetic process
MCU78_RS20205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MCU78_RS20205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MCU78_RS20205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MCU78_RS20210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MCU78_RS20240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MCU78_RS20245	COG0745	RESPONSE REGULATOR receiver
MCU78_RS20250	COG5002	protein histidine kinase activity
MCU78_RS20255	COG0823	Involved in the tonB-independent uptake of proteins
MCU78_RS20265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MCU78_RS20270	COG2197	response regulator
MCU78_RS20285	COG0653	protein targeting
MCU78_RS20320	COG0463	Glycosyl transferase, family 2
MCU78_RS20335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MCU78_RS20345	COG1215	transferase activity, transferring glycosyl groups
MCU78_RS20355	COG0395	ABC-type sugar transport system, permease component
MCU78_RS20360	COG1175	transmembrane transport
MCU78_RS20365	COG1653	transport
MCU78_RS20380	COG0515	serine threonine protein kinase
MCU78_RS20385	COG0515	serine threonine protein kinase
MCU78_RS20390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MCU78_RS20405	COG2884	Cell division ATP-binding protein ftsE
MCU78_RS20410	COG2177	Part of the ABC transporter FtsEX involved in
MCU78_RS20415	COG0793	Belongs to the peptidase S41A family
MCU78_RS20420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MCU78_RS20440	COG0583	DNA-binding transcription factor activity
MCU78_RS20455	COG3973	AAA domain
MCU78_RS20465	COG0776	regulation of translation
MCU78_RS20470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MCU78_RS20475	COG1678	Uncharacterized ACR, COG1678
MCU78_RS20485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MCU78_RS20500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCU78_RS20540	COG1404	Belongs to the peptidase S8 family
MCU78_RS20580	COG0583	DNA-binding transcription factor activity
MCU78_RS20590	COG2855	membrane
MCU78_RS20605	COG3654	unkown
MCU78_RS20630	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MCU78_RS20635	COG0277	FAD linked oxidase domain protein
MCU78_RS20665	COG1335	isochorismatase
MCU78_RS20675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MCU78_RS20685	COG1113	amino acid transport
MCU78_RS20710	COG1234	tRNA 3'-trailer cleavage
MCU78_RS20715	COG1263	PTS System
MCU78_RS20720	COG1263	PTS System
MCU78_RS20725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MCU78_RS20730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MCU78_RS20740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MCU78_RS20760	COG2205	protein histidine kinase activity
MCU78_RS20775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MCU78_RS20785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCU78_RS20820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCU78_RS20835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCU78_RS20845	COG0706	membrane insertase activity
MCU78_RS20895	COG0673	inositol 2-dehydrogenase activity
MCU78_RS20900	COG1940	carbohydrate kinase activity
MCU78_RS20945	COG2186	Transcriptional regulator
MCU78_RS20955	COG0791	NLP P60 protein
MCU78_RS20955	COG0741	lytic transglycosylase activity
MCU78_RS20965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MCU78_RS20965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MCU78_RS20985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCU78_RS21035	COG0406	alpha-ribazole phosphatase activity
MCU78_RS21060	COG0395	ABC-type sugar transport system, permease component
MCU78_RS21080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MCU78_RS21085	COG4977	sequence-specific DNA binding
MCU78_RS21095	COG0589	response to stress
MCU78_RS21100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MCU78_RS21115	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS21130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MCU78_RS21135	COG1309	transcriptional regulator
MCU78_RS21145	COG1946	Acyl-CoA thioesterase
MCU78_RS21205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MCU78_RS21215	COG0583	DNA-binding transcription factor activity
MCU78_RS21225	COG1280	lysine exporter protein (LysE YggA)
MCU78_RS21235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCU78_RS21255	COG0673	inositol 2-dehydrogenase activity
MCU78_RS21265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MCU78_RS21275	COG3718	enzyme involved in inositol metabolism
MCU78_RS21280	COG3962	Belongs to the TPP enzyme family
MCU78_RS21290	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MCU78_RS21295	COG4566	intracellular signal transduction
MCU78_RS21315	COG3226	Transcriptional regulator
MCU78_RS21320	COG3402	PFAM membrane-flanked domain
MCU78_RS21350	COG2814	Major facilitator Superfamily
MCU78_RS21355	COG2267	carboxylic ester hydrolase activity
MCU78_RS21385	COG1819	glycosyl
MCU78_RS21470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MCU78_RS21475	COG1053	succinate dehydrogenase
MCU78_RS21485	COG0583	DNA-binding transcription factor activity
MCU78_RS21490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MCU78_RS21495	COG1993	acr, cog1993
MCU78_RS21500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MCU78_RS21520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MCU78_RS21535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MCU78_RS21545	COG0477	Major facilitator Superfamily
MCU78_RS21550	COG1846	Transcriptional regulator
MCU78_RS21575	COG0629	single-stranded DNA binding
MCU78_RS21630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCU78_RS21645	COG1486	melibiose metabolic process
MCU78_RS21660	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS21665	COG0668	transmembrane transport
MCU78_RS21685	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
MCU78_RS21765	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MCU78_RS21775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MCU78_RS21780	COG1113	amino acid transport
MCU78_RS21785	COG1113	amino acid transport
MCU78_RS21800	COG1113	amino acid transport
MCU78_RS21825	COG3594	Acyltransferase
MCU78_RS21845	COG0544	peptidyl-prolyl cis-trans isomerase activity
MCU78_RS21850	COG0740	serine-type endopeptidase activity
MCU78_RS21855	COG0740	serine-type endopeptidase activity
MCU78_RS21860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MCU78_RS21890	COG0525	valine-tRNA ligase activity
MCU78_RS21900	COG1215	transferase activity, transferring glycosyl groups
MCU78_RS21915	COG2205	protein histidine kinase activity
MCU78_RS21920	COG0285	dihydrofolate synthase activity
MCU78_RS21930	COG0105	UTP biosynthetic process
MCU78_RS21935	COG1077	Cell shape determining protein MreB Mrl
MCU78_RS21950	COG0768	penicillin binding
MCU78_RS21955	COG0772	Belongs to the SEDS family
MCU78_RS21975	COG1530	ribonuclease E activity
MCU78_RS21980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MCU78_RS21985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MCU78_RS21990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MCU78_RS22000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MCU78_RS22010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MCU78_RS22025	COG0501	Belongs to the peptidase M48B family
MCU78_RS22040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MCU78_RS22050	COG0799	negative regulation of ribosome biogenesis
MCU78_RS22055	COG0588	phosphoglycerate mutase activity
MCU78_RS22070	COG0477	Major facilitator Superfamily
MCU78_RS22090	COG0495	leucyl-tRNA aminoacylation
MCU78_RS22100	COG1307	EDD domain protein, DegV family
MCU78_RS22125	COG0268	Binds directly to 16S ribosomal RNA
MCU78_RS22130	COG0481	GTPase activity
MCU78_RS22160	COG1420	regulation of RNA biosynthetic process
MCU78_RS22165	COG0484	heat shock protein binding
MCU78_RS22185	COG2249	NAD(P)H dehydrogenase (quinone) activity
MCU78_RS22190	COG0537	adenosine 5'-monophosphoramidase activity
MCU78_RS22195	COG1234	tRNA 3'-trailer cleavage
MCU78_RS22205	COG1486	melibiose metabolic process
MCU78_RS22220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MCU78_RS22260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MCU78_RS22290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MCU78_RS22300	COG1381	Involved in DNA repair and RecF pathway recombination
MCU78_RS22305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MCU78_RS22315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MCU78_RS22320	COG1121	(ABC) transporter
MCU78_RS22325	COG0803	Belongs to the bacterial solute-binding protein 9 family
MCU78_RS22325	COG3443	Belongs to the bacterial solute-binding protein 9 family
MCU78_RS22330	COG0423	glycine-tRNA ligase activity
MCU78_RS22375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCU78_RS22375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCU78_RS22435	COG2197	response regulator
MCU78_RS22470	COG0667	Aldo Keto reductase
MCU78_RS22475	COG0477	Major facilitator Superfamily
MCU78_RS22490	COG0574	Belongs to the PEP-utilizing enzyme family
MCU78_RS22490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCU78_RS22500	COG0395	ABC-type sugar transport system, permease component
MCU78_RS22515	COG1215	transferase activity, transferring glycosyl groups
MCU78_RS22520	COG0531	amino acid
MCU78_RS22530	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS22545	COG2949	membrane
MCU78_RS22550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MCU78_RS22560	COG0358	DNA primase activity
MCU78_RS22565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MCU78_RS22570	COG1070	Carbohydrate kinase
MCU78_RS22600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCU78_RS22605	COG0588	phosphoglycerate mutase activity
MCU78_RS22615	COG3619	membrane
MCU78_RS22635	COG2130	NADP-dependent
MCU78_RS22640	COG1764	response to oxidative stress
MCU78_RS22655	COG1285	pathogenesis
MCU78_RS22670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MCU78_RS22675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCU78_RS22680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS22685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MCU78_RS22710	COG0789	Transcriptional regulator
MCU78_RS22715	COG2197	response regulator
MCU78_RS22720	COG4585	Histidine kinase
MCU78_RS22735	COG1309	transcriptional regulator
MCU78_RS22740	COG0477	Major facilitator Superfamily
MCU78_RS22745	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MCU78_RS22790	COG1358	cellular component organization or biogenesis
MCU78_RS22915	COG0406	alpha-ribazole phosphatase activity
MCU78_RS22940	COG5640	endopeptidase activity
MCU78_RS22975	COG1595	DNA-templated transcription, initiation
MCU78_RS23110	COG1309	transcriptional regulator
MCU78_RS23115	COG0438	transferase activity, transferring glycosyl groups
MCU78_RS23145	COG0860	N-Acetylmuramoyl-L-alanine amidase
MCU78_RS23155	COG2197	response regulator
MCU78_RS23160	COG4585	Histidine kinase
MCU78_RS23165	COG2030	dehydratase
MCU78_RS23180	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MCU78_RS23185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MCU78_RS23255	COG0181	hydroxymethylbilane synthase activity
MCU78_RS23260	COG0494	nUDIX hydrolase
MCU78_RS23280	COG0557	exoribonuclease II activity
MCU78_RS23285	COG3022	response to hydroperoxide
MCU78_RS23370	COG2814	Major facilitator Superfamily
MCU78_RS23380	COG1834	amidinotransferase
MCU78_RS23405	COG0672	)-iron permease
MCU78_RS23410	COG2837	iron assimilation
MCU78_RS23415	COG2822	iron ion transport
MCU78_RS23425	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MCU78_RS23445	COG4221	oxidoreductase activity
MCU78_RS23450	COG0346	lactoylglutathione lyase activity
MCU78_RS23485	COG0454	-acetyltransferase
MCU78_RS23490	COG2226	methyltransferase
MCU78_RS23525	COG1309	transcriptional regulator
MCU78_RS23605	COG1994	Peptidase M50
MCU78_RS23625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MCU78_RS23630	COG0477	Major facilitator Superfamily
MCU78_RS23635	COG1309	transcriptional regulator
MCU78_RS23655	COG0154	amidase activity
MCU78_RS23665	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MCU78_RS23685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MCU78_RS23685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCU78_RS23690	COG2132	Multicopper oxidase
MCU78_RS23700	COG0531	amino acid
MCU78_RS23705	COG2267	carboxylic ester hydrolase activity
MCU78_RS23730	COG0789	Transcriptional regulator
MCU78_RS23735	COG1819	glycosyl
MCU78_RS23765	COG0667	Aldo Keto reductase
MCU78_RS23770	COG0789	Transcriptional regulator
MCU78_RS23780	COG0174	glutamine synthetase
MCU78_RS23795	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MCU78_RS23805	COG1609	Transcriptional regulator
MCU78_RS23810	COG0366	Alpha amylase catalytic
MCU78_RS23815	COG3833	ABC-type maltose transport systems, permease component
MCU78_RS23825	COG1653	transport
MCU78_RS23845	COG2365	Tyrosine phosphatase family
MCU78_RS23855	COG2197	response regulator
MCU78_RS23875	COG0745	RESPONSE REGULATOR receiver
MCU78_RS23880	COG1619	proteins homologs of microcin C7 resistance protein MccF
MCU78_RS23885	COG0671	phosphoesterase, PA-phosphatase related
MCU78_RS23890	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS23945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MCU78_RS23950	COG0321	lipoyl(octanoyl) transferase activity
MCU78_RS23990	COG0508	dehydrogenase complex catalyzes the overall conversion of
MCU78_RS23995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCU78_RS24000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MCU78_RS24005	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MCU78_RS24020	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MCU78_RS24020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MCU78_RS24025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MCU78_RS24060	COG4585	Histidine kinase
MCU78_RS24065	COG2197	response regulator
MCU78_RS24070	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MCU78_RS24090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MCU78_RS24095	COG1104	cysteine desulfurase activity
MCU78_RS24100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MCU78_RS24105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCU78_RS24115	COG1376	ErfK ybiS ycfS ynhG family protein
MCU78_RS24125	COG1845	cytochrome c oxidase, subunit III
MCU78_RS24130	COG2010	Cytochrome c
MCU78_RS24135	COG0723	plastoquinol--plastocyanin reductase activity
MCU78_RS24140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MCU78_RS24145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MCU78_RS24150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MCU78_RS24165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MCU78_RS24180	COG2409	Drug exporters of the RND superfamily
MCU78_RS24190	COG2226	methyltransferase
MCU78_RS24205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCU78_RS24225	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MCU78_RS24230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MCU78_RS24285	COG0791	NLP P60 protein
MCU78_RS24370	COG0003	Pfam Anion-transporting ATPase
MCU78_RS24380	COG1940	carbohydrate kinase activity
MCU78_RS24415	COG2197	response regulator
MCU78_RS24420	COG0205	6-phosphofructokinase activity
MCU78_RS24425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MCU78_RS24430	COG2193	ferroxidase activity
MCU78_RS24435	COG0243	molybdopterin cofactor binding
MCU78_RS24440	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MCU78_RS24450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MCU78_RS24455	COG0515	serine threonine protein kinase
MCU78_RS24455	COG2815	serine threonine protein kinase
MCU78_RS24460	COG2022	thiamine diphosphate biosynthetic process
MCU78_RS24470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MCU78_RS24470	COG2022	thiamine diphosphate biosynthetic process
MCU78_RS24485	COG0352	thiamine-phosphate diphosphorylase activity
MCU78_RS24495	COG1132	(ABC) transporter
MCU78_RS24540	COG1309	transcriptional regulator
MCU78_RS24550	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MCU78_RS24560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCU78_RS24580	COG0714	Associated with various cellular activities
MCU78_RS24590	COG0275	rRNA processing
MCU78_RS24600	COG0768	penicillin binding
MCU78_RS24605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MCU78_RS24615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MCU78_RS24620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MCU78_RS24630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MCU78_RS24635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MCU78_RS24640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MCU78_RS24655	COG1799	cell septum assembly
MCU78_RS24665	COG3599	regulation of cell shape
MCU78_RS24670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MCU78_RS24685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MCU78_RS24700	COG0025	NhaP-type Na H and K H
MCU78_RS24740	COG0587	DNA-directed DNA polymerase activity
MCU78_RS24750	COG1432	Conserved Protein
MCU78_RS24785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MCU78_RS24790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCU78_RS24795	COG0131	Imidazoleglycerol-phosphate dehydratase
MCU78_RS24805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MCU78_RS24810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MCU78_RS24815	COG0251	oxidation-reduction process
MCU78_RS24820	COG0107	imidazoleglycerol-phosphate synthase activity
MCU78_RS24835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MCU78_RS24860	COG0134	indole-3-glycerol-phosphate synthase activity
MCU78_RS24865	COG0133	tryptophan synthase activity
MCU78_RS24870	COG0159	tryptophan synthase activity
MCU78_RS24880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MCU78_RS24890	COG0070	glutamate synthase
MCU78_RS24890	COG0067	glutamate synthase
MCU78_RS24890	COG0069	glutamate synthase activity
MCU78_RS24905	COG1051	belongs to the nudix hydrolase family
MCU78_RS24950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MCU78_RS24955	COG1215	transferase activity, transferring glycosyl groups
MCU78_RS24990	COG2197	response regulator
MCU78_RS25000	COG0740	serine-type endopeptidase activity
MCU78_RS25005	COG0583	DNA-binding transcription factor activity
MCU78_RS25020	COG0287	Prephenate dehydrogenase
MCU78_RS25020	COG1605	Chorismate mutase
MCU78_RS25030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MCU78_RS25040	COG0737	Belongs to the 5'-nucleotidase family
MCU78_RS25075	COG0411	ABC transporter
MCU78_RS25095	COG2050	protein possibly involved in aromatic compounds catabolism
MCU78_RS25115	COG1643	Atp-dependent helicase
MCU78_RS25125	COG2226	methyltransferase
MCU78_RS25130	COG0539	negative regulation of cytoplasmic translation
MCU78_RS25140	COG0237	dephospho-CoA kinase activity
MCU78_RS25160	COG0584	glycerophosphoryl diester phosphodiesterase
MCU78_RS25165	COG0556	nucleotide-excision repair
MCU78_RS25170	COG2310	stress, protein
MCU78_RS25200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MCU78_RS25225	COG0322	excinuclease ABC activity
MCU78_RS25230	COG1660	Displays ATPase and GTPase activities
MCU78_RS25235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MCU78_RS25240	COG1481	regulation of sporulation
MCU78_RS25250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MCU78_RS25255	COG0126	phosphoglycerate kinase activity
MCU78_RS25260	COG0149	triose-phosphate isomerase activity
MCU78_RS25265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MCU78_RS25275	COG0166	Belongs to the GPI family
MCU78_RS25280	COG0363	glucosamine-6-phosphate deaminase activity
MCU78_RS25295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MCU78_RS25300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MCU78_RS25305	COG0109	protoheme IX farnesyltransferase activity
MCU78_RS25315	COG1612	heme a metabolic process
MCU78_RS25325	COG1131	(ABC) transporter
MCU78_RS25340	COG0719	Fe-S assembly protein
MCU78_RS25350	COG0396	ATPase activity
MCU78_RS25355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MCU78_RS25360	COG0822	iron-sulfur transferase activity
MCU78_RS25385	COG1309	transcriptional regulator
MCU78_RS25395	COG2076	Multidrug Resistance protein
MCU78_RS25400	COG3226	Transcriptional regulator
MCU78_RS25405	COG2171	N-acyltransferase activity
MCU78_RS25410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MCU78_RS25425	COG0702	epimerase
MCU78_RS25430	COG1733	regulation of RNA biosynthetic process
MCU78_RS25475	COG4977	sequence-specific DNA binding
MCU78_RS25505	COG1131	(ABC) transporter
MCU78_RS25530	COG0583	DNA-binding transcription factor activity
MCU78_RS25535	COG0251	oxidation-reduction process
MCU78_RS25595	COG0438	transferase activity, transferring glycosyl groups
MCU78_RS25615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCU78_RS25640	COG2197	response regulator
MCU78_RS25645	COG4585	Histidine kinase
MCU78_RS25650	COG2345	Transcriptional regulator
MCU78_RS25675	COG2080	2 iron, 2 sulfur cluster binding
MCU78_RS25680	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MCU78_RS25685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MCU78_RS25695	COG1797	cobyrinic acid a,c-diamide synthase activity
MCU78_RS25710	COG1492	cobalamin metabolic process
MCU78_RS25730	COG0235	Class ii aldolase
MCU78_RS25755	COG0488	(ABC) transporter
MCU78_RS25765	COG1024	Enoyl-CoA hydratase
MCU78_RS25840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCU78_RS25845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MCU78_RS25865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MCU78_RS25880	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS25885	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MCU78_RS25895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCU78_RS25900	COG2807	transmembrane transport
MCU78_RS25915	COG0560	Phosphoserine phosphatase
MCU78_RS25915	COG3830	Belongs to the UPF0237 family
MCU78_RS25925	COG1716	ATPase activity
MCU78_RS25925	COG1131	(ABC) transporter
MCU78_RS25925	COG0842	Transport permease protein
MCU78_RS25940	COG4585	Histidine kinase
MCU78_RS25945	COG2197	response regulator
MCU78_RS25965	COG1119	ATPase activity
MCU78_RS25990	COG1881	PFAM PEBP family protein
MCU78_RS26005	COG2094	Belongs to the DNA glycosylase MPG family
MCU78_RS26040	COG0647	UMP catabolic process
MCU78_RS26055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS26060	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS26065	COG1120	ATPase activity
MCU78_RS26085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MCU78_RS26095	COG0497	DNA recombination
MCU78_RS26115	COG3387	PFAM Glycoside hydrolase 15-related
MCU78_RS26120	COG0504	CTP synthase activity
MCU78_RS26125	COG0494	nUDIX hydrolase
MCU78_RS26135	COG0686	Belongs to the AlaDH PNT family
MCU78_RS26160	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MCU78_RS26165	COG1187	pseudouridine synthase activity
MCU78_RS26170	COG3541	Predicted nucleotidyltransferase
MCU78_RS26200	COG1160	GTP binding
MCU78_RS26215	COG0438	transferase activity, transferring glycosyl groups
MCU78_RS26225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCU78_RS26245	COG0477	Major facilitator Superfamily
MCU78_RS26250	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS26255	COG1799	cell septum assembly
MCU78_RS26270	COG0330	HflC and HflK could
MCU78_RS26285	COG0587	DNA-directed DNA polymerase activity
MCU78_RS26290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MCU78_RS26325	COG0367	asparagine synthase
MCU78_RS26330	COG1725	Transcriptional regulator
MCU78_RS26365	COG0463	Glycosyl transferase, family 2
MCU78_RS26380	COG2755	lipolytic protein G-D-S-L family
MCU78_RS26390	COG2188	Transcriptional regulator
MCU78_RS26395	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MCU78_RS26405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCU78_RS26455	COG1846	Transcriptional regulator
MCU78_RS26460	COG2814	Major facilitator Superfamily
MCU78_RS26475	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS26485	COG3209	COG3209 Rhs family protein
MCU78_RS26495	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MCU78_RS26515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS26520	COG0028	Belongs to the TPP enzyme family
MCU78_RS26530	COG0028	Belongs to the TPP enzyme family
MCU78_RS26535	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MCU78_RS26550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCU78_RS26580	COG0667	Aldo Keto reductase
MCU78_RS26585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCU78_RS26600	COG0406	alpha-ribazole phosphatase activity
MCU78_RS26615	COG0215	cysteine-tRNA ligase activity
MCU78_RS26650	COG2186	Transcriptional regulator
MCU78_RS26685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MCU78_RS26690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MCU78_RS26695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MCU78_RS26700	COG1414	Transcriptional regulator
MCU78_RS26705	COG0646	methionine synthase
MCU78_RS26705	COG1410	methionine synthase
MCU78_RS26715	COG0747	negative chemotaxis
MCU78_RS26725	COG2197	response regulator
MCU78_RS26735	COG1994	Peptidase M50
MCU78_RS26735	COG0517	IMP dehydrogenase activity
MCU78_RS26755	COG1222	aaa ATPase
MCU78_RS26760	COG4122	O-methyltransferase activity
MCU78_RS26775	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MCU78_RS26780	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MCU78_RS26785	COG1609	Transcriptional regulator
MCU78_RS26795	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MCU78_RS26830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MCU78_RS26835	COG0805	protein transport
MCU78_RS26875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCU78_RS26880	COG0517	IMP dehydrogenase activity
MCU78_RS26880	COG4175	Glycine betaine
MCU78_RS26905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MCU78_RS26915	COG0174	glutamine synthetase
MCU78_RS26945	COG1404	Belongs to the peptidase S8 family
MCU78_RS26965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MCU78_RS26970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MCU78_RS26975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MCU78_RS26980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCU78_RS26985	COG5002	protein histidine kinase activity
MCU78_RS26990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MCU78_RS26995	COG0072	phenylalanine-tRNA ligase activity
MCU78_RS26995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCU78_RS27025	COG1280	lysine exporter protein (LysE YggA)
MCU78_RS27050	COG1649	PFAM Uncharacterised BCR, COG1649
MCU78_RS27060	COG0697	spore germination
MCU78_RS27065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCU78_RS27080	COG1309	transcriptional regulator
MCU78_RS27105	COG2197	response regulator
MCU78_RS27115	COG0488	(ABC) transporter
MCU78_RS27140	COG4335	DNA alkylation repair
MCU78_RS27145	COG0477	Major facilitator Superfamily
MCU78_RS27150	COG2814	Major facilitator Superfamily
MCU78_RS27155	COG1846	Transcriptional regulator
MCU78_RS27215	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MCU78_RS27220	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MCU78_RS27225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MCU78_RS27230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCU78_RS27235	COG1438	arginine binding
MCU78_RS27340	COG2197	response regulator
MCU78_RS27345	COG4585	Histidine kinase
MCU78_RS27370	COG0137	argininosuccinate synthase activity
MCU78_RS27375	COG0165	Argininosuccinate lyase
MCU78_RS27385	COG0477	Major facilitator Superfamily
MCU78_RS27390	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MCU78_RS27395	COG0204	Acyl-transferase
MCU78_RS27395	COG0318	PFAM AMP-dependent synthetase and ligase
MCU78_RS27425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MCU78_RS27430	COG2011	ABC-type metal ion transport system permease component
MCU78_RS27435	COG1464	Belongs to the NlpA lipoprotein family
MCU78_RS27455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MCU78_RS27460	COG1648	precorrin-2 dehydrogenase activity
MCU78_RS27460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MCU78_RS27465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCU78_RS27470	COG2124	cytochrome p450
MCU78_RS27520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MCU78_RS27570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MCU78_RS27585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MCU78_RS27615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MCU78_RS27625	COG0438	transferase activity, transferring glycosyl groups
MCU78_RS27640	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MCU78_RS27645	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MCU78_RS27650	COG0217	transcriptional regulatory protein
MCU78_RS27655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MCU78_RS27660	COG0632	four-way junction helicase activity
MCU78_RS27665	COG2255	four-way junction helicase activity
MCU78_RS27675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MCU78_RS27680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MCU78_RS27685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MCU78_RS27690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MCU78_RS27695	COG1196	nuclear chromosome segregation
MCU78_RS27700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MCU78_RS27710	COG0124	histidyl-tRNA synthetase
MCU78_RS27730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MCU78_RS27745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MCU78_RS27760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MCU78_RS27765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MCU78_RS27770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MCU78_RS27775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MCU78_RS27780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MCU78_RS27790	COG0006	proline dipeptidase activity
MCU78_RS27795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MCU78_RS27800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MCU78_RS27810	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MCU78_RS27815	COG0540	Belongs to the ATCase OTCase family
MCU78_RS27820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MCU78_RS27830	COG0505	Belongs to the CarA family
MCU78_RS27835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MCU78_RS27840	COG0167	dihydroorotate dehydrogenase activity
MCU78_RS27845	COG0284	orotidine-5'-phosphate decarboxylase activity
MCU78_RS27870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MCU78_RS27885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MCU78_RS27895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MCU78_RS27900	COG2390	Transcriptional regulator
MCU78_RS27925	COG0531	amino acid
MCU78_RS27960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCU78_RS27975	COG2233	PERMEase
MCU78_RS27985	COG0738	Major facilitator superfamily
MCU78_RS28000	COG3201	nicotinamide mononucleotide transporter
MCU78_RS28005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MCU78_RS28005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MCU78_RS28010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MCU78_RS28015	COG0140	phosphoribosyl-ATP diphosphatase activity
MCU78_RS28020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MCU78_RS28070	COG5001	Diguanylate cyclase
MCU78_RS28120	COG0574	Belongs to the PEP-utilizing enzyme family
MCU78_RS28120	COG3848	Pyruvate phosphate dikinase
MCU78_RS28125	COG1819	glycosyl
MCU78_RS28130	COG2409	Drug exporters of the RND superfamily
MCU78_RS28140	COG0702	epimerase
MCU78_RS28190	COG2814	Major facilitator Superfamily
MCU78_RS28205	COG2378	regulation of single-species biofilm formation
MCU78_RS28255	COG0142	geranyltranstransferase activity
MCU78_RS28260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MCU78_RS28285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MCU78_RS28290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MCU78_RS28295	COG3170	Tfp pilus assembly protein FimV
MCU78_RS28570	COG1278	Cold shock
MCU78_RS28595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MCU78_RS28675	COG4221	oxidoreductase activity
MCU78_RS28690	COG3387	PFAM Glycoside hydrolase 15-related
MCU78_RS28695	COG2814	Major facilitator Superfamily
MCU78_RS28700	COG1846	Transcriptional regulator
MCU78_RS28705	COG0657	acetylesterase activity
MCU78_RS28760	COG1914	H( )-stimulated, divalent metal cation uptake system
MCU78_RS28770	COG0583	DNA-binding transcription factor activity
MCU78_RS28815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MCU78_RS28820	COG0302	gtp cyclohydrolase
MCU78_RS28830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MCU78_RS28835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MCU78_RS28850	COG0720	synthase
MCU78_RS28855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MCU78_RS28860	COG0242	peptide deformylase activity
MCU78_RS28935	COG1012	belongs to the aldehyde dehydrogenase family
MCU78_RS28990	COG1120	ATPase activity
MCU78_RS28995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS29010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCU78_RS29010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MCU78_RS29010	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MCU78_RS29040	COG1309	transcriptional regulator
MCU78_RS29045	COG1960	acyl-CoA dehydrogenase activity
MCU78_RS29070	COG0463	Glycosyl transferase, family 2
MCU78_RS29075	COG3030	protein affecting phage T7 exclusion by the F plasmid
MCU78_RS29090	COG2186	Transcriptional regulator
MCU78_RS29130	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MCU78_RS29140	COG1793	dna ligase
MCU78_RS29175	COG0438	transferase activity, transferring glycosyl groups
MCU78_RS29180	COG1984	allophanate hydrolase subunit 2
MCU78_RS29185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MCU78_RS29190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MCU78_RS29195	COG1802	Transcriptional regulator
MCU78_RS29250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCU78_RS29260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCU78_RS29290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MCU78_RS29335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MCU78_RS29345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCU78_RS29345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCU78_RS29375	COG1695	Transcriptional regulator
MCU78_RS29405	COG0697	spore germination
MCU78_RS29440	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS29445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MCU78_RS29465	COG2378	regulation of single-species biofilm formation
MCU78_RS29470	COG2318	DinB family
MCU78_RS29480	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MCU78_RS29525	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MCU78_RS29530	COG3285	dna ligase
MCU78_RS29530	COG1793	dna ligase
MCU78_RS29535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MCU78_RS29535	COG1796	DNA polymerase
MCU78_RS29585	COG0640	Transcriptional regulator
MCU78_RS29605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCU78_RS29720	COG1120	ATPase activity
MCU78_RS29725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS29730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS29735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MCU78_RS29765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MCU78_RS29775	COG1247	-acetyltransferase
MCU78_RS29860	COG1660	Displays ATPase and GTPase activities
MCU78_RS29890	COG1595	DNA-templated transcription, initiation
MCU78_RS29910	COG0445	tRNA wobble uridine modification
MCU78_RS29940	COG2223	nitrite transmembrane transporter activity
MCU78_RS29955	COG4977	sequence-specific DNA binding
MCU78_RS29970	COG0464	growth
MCU78_RS29980	COG0633	Ferredoxin
MCU78_RS29980	COG3217	Mosc domain protein beta barrel domain protein
MCU78_RS29995	COG1215	transferase activity, transferring glycosyl groups
MCU78_RS30000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MCU78_RS30020	COG2376	Dihydroxyacetone kinase
MCU78_RS30050	COG0302	gtp cyclohydrolase
MCU78_RS30125	COG0574	Belongs to the PEP-utilizing enzyme family
MCU78_RS30125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCU78_RS30135	COG2197	response regulator
MCU78_RS30200	COG0076	glutamate decarboxylase activity
MCU78_RS30265	COG3629	intracellular signal transduction
MCU78_RS30265	COG3903	Transcriptional regulator
MCU78_RS30285	COG0405	Gamma-glutamyltransferase
MCU78_RS30290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCU78_RS30305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS30365	COG2340	Cysteine-rich secretory protein family
MCU78_RS30415	COG0500	methyltransferase
MCU78_RS30425	COG0367	asparagine synthase
MCU78_RS30430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCU78_RS30445	COG2197	response regulator
MCU78_RS30460	COG0671	phosphoesterase, PA-phosphatase related
MCU78_RS30465	COG0515	serine threonine protein kinase
MCU78_RS30480	COG1733	regulation of RNA biosynthetic process
MCU78_RS30485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MCU78_RS30555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCU78_RS30560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCU78_RS30610	COG1793	dna ligase
MCU78_RS30640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MCU78_RS30660	COG1280	lysine exporter protein (LysE YggA)
MCU78_RS30670	COG0515	serine threonine protein kinase
MCU78_RS30680	COG0596	Alpha beta hydrolase
MCU78_RS30700	COG0438	transferase activity, transferring glycosyl groups
MCU78_RS30715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MCU78_RS30735	COG0791	NLP P60 protein
MCU78_RS30750	COG3012	SEC-C Motif Domain Protein
MCU78_RS30800	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MCU78_RS30825	COG1522	sequence-specific DNA binding
MCU78_RS30835	COG0667	Aldo Keto reductase
MCU78_RS30840	COG1733	regulation of RNA biosynthetic process
MCU78_RS30870	COG0702	epimerase
MCU78_RS30895	COG0477	Major facilitator Superfamily
MCU78_RS30930	COG2814	Major facilitator Superfamily
MCU78_RS30935	COG1316	TRANSCRIPTIONal
MCU78_RS31010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MCU78_RS31015	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MCU78_RS31035	COG0596	Alpha beta hydrolase
MCU78_RS31040	COG0477	Major facilitator Superfamily
MCU78_RS31065	COG0604	alcohol dehydrogenase
MCU78_RS31065	COG3321	synthase
MCU78_RS31070	COG0604	alcohol dehydrogenase
MCU78_RS31070	COG3321	synthase
MCU78_RS31075	COG0604	alcohol dehydrogenase
MCU78_RS31075	COG3321	synthase
MCU78_RS31135	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS31140	COG1959	2 iron, 2 sulfur cluster binding
MCU78_RS31145	COG0697	spore germination
MCU78_RS31160	COG0583	DNA-binding transcription factor activity
MCU78_RS31165	COG0596	Alpha beta hydrolase
MCU78_RS31175	COG0179	Fumarylacetoacetate (FAA) hydrolase
MCU78_RS31230	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS31235	COG2030	dehydratase
MCU78_RS31240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCU78_RS31265	COG0673	inositol 2-dehydrogenase activity
MCU78_RS31275	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS31310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MCU78_RS31325	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MCU78_RS31345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCU78_RS31370	COG0583	DNA-binding transcription factor activity
MCU78_RS31385	COG0655	NAD(P)H dehydrogenase (quinone) activity
MCU78_RS31405	COG1683	Conserved Protein
MCU78_RS31410	COG2318	DinB family
MCU78_RS31440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCU78_RS31460	COG1051	belongs to the nudix hydrolase family
MCU78_RS31475	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MCU78_RS31495	COG0028	Belongs to the TPP enzyme family
MCU78_RS31520	COG1309	transcriptional regulator
MCU78_RS31620	COG3265	gluconokinase activity
MCU78_RS31650	COG0318	PFAM AMP-dependent synthetase and ligase
MCU78_RS31675	COG2223	nitrite transmembrane transporter activity
MCU78_RS31685	COG1278	Cold shock
MCU78_RS31690	COG3321	synthase
MCU78_RS31690	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS31690	COG0604	alcohol dehydrogenase
MCU78_RS31695	COG1834	amidinotransferase
MCU78_RS31705	COG2030	dehydratase
MCU78_RS31715	COG2301	Belongs to the HpcH HpaI aldolase family
MCU78_RS31730	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MCU78_RS31740	COG2234	aminopeptidase activity
MCU78_RS31745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MCU78_RS31755	COG2205	protein histidine kinase activity
MCU78_RS31760	COG0745	RESPONSE REGULATOR receiver
MCU78_RS31780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCU78_RS31800	COG2011	ABC-type metal ion transport system permease component
MCU78_RS31805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MCU78_RS31810	COG1464	Belongs to the NlpA lipoprotein family
MCU78_RS31815	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MCU78_RS31825	COG1482	cell wall glycoprotein biosynthetic process
MCU78_RS31830	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS31845	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS31860	COG0723	plastoquinol--plastocyanin reductase activity
MCU78_RS31860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MCU78_RS31900	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS31905	COG1573	uracil-dna glycosylase
MCU78_RS31930	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MCU78_RS31935	COG0438	transferase activity, transferring glycosyl groups
MCU78_RS31960	COG2192	nodulation
MCU78_RS31995	COG2890	protein-(glutamine-N5) methyltransferase activity
MCU78_RS32010	COG1982	Orn Lys Arg decarboxylase major
MCU78_RS32015	COG0640	Transcriptional regulator
MCU78_RS32020	COG2814	Major facilitator Superfamily
MCU78_RS32060	COG4585	Histidine kinase
MCU78_RS32075	COG2267	carboxylic ester hydrolase activity
MCU78_RS32095	COG0243	molybdopterin cofactor binding
MCU78_RS32100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCU78_RS32100	COG2146	nitrite reductase [NAD(P)H] activity
MCU78_RS32105	COG2146	nitrite reductase [NAD(P)H] activity
MCU78_RS32105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCU78_RS32115	COG2223	nitrite transmembrane transporter activity
MCU78_RS32145	COG0583	DNA-binding transcription factor activity
MCU78_RS32150	COG1073	alpha beta
MCU78_RS32150	COG2226	methyltransferase
MCU78_RS32190	COG2813	Specifically methylates the guanine in position
MCU78_RS32195	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MCU78_RS32200	COG2814	Major facilitator Superfamily
MCU78_RS32225	COG2814	Major facilitator Superfamily
MCU78_RS32265	COG2814	Major facilitator Superfamily
MCU78_RS32280	COG3979	chitinase
MCU78_RS32290	COG1366	Belongs to the anti-sigma-factor antagonist family
MCU78_RS32290	COG2208	phosphoserine phosphatase activity
MCU78_RS32290	COG2172	sigma factor antagonist activity
MCU78_RS32295	COG0475	glutathione-regulated potassium exporter activity
MCU78_RS32295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MCU78_RS32305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MCU78_RS32310	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MCU78_RS32315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MCU78_RS32320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCU78_RS32325	COG3486	L-lysine 6-monooxygenase (NADPH) activity
MCU78_RS32330	COG3433	isochorismatase activity
MCU78_RS32330	COG1535	isochorismatase
MCU78_RS32335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MCU78_RS32355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS32365	COG1132	(ABC) transporter
MCU78_RS32370	COG1132	(ABC) transporter
MCU78_RS32375	COG2375	cellular response to nickel ion
MCU78_RS32380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS32385	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCU78_RS32390	COG0473	3-isopropylmalate dehydrogenase activity
MCU78_RS32405	COG3135	benzoate transporter
MCU78_RS32420	COG2207	Transcriptional regulator
MCU78_RS32450	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS32480	COG1295	ribonuclease BN
MCU78_RS32510	COG0789	Transcriptional regulator
MCU78_RS32520	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS32535	COG2175	clavaminate synthase activity
MCU78_RS32550	COG0300	oxidoreductase activity
MCU78_RS32550	COG0318	PFAM AMP-dependent synthetase and ligase
MCU78_RS32550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCU78_RS32550	COG1028	Short-chain dehydrogenase reductase Sdr
MCU78_RS32550	COG3321	synthase
MCU78_RS32565	COG0726	polysaccharide deacetylase
MCU78_RS32595	COG1113	amino acid transport
MCU78_RS32600	COG0387	Pfam Sodium calcium exchanger
MCU78_RS32625	COG0456	acetyltransferase
MCU78_RS32630	COG1335	isochorismatase
MCU78_RS32665	COG2264	protein methyltransferase activity
MCU78_RS32715	COG1595	DNA-templated transcription, initiation
MCU78_RS32735	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
MCU78_RS32750	COG0596	Alpha beta hydrolase
MCU78_RS32760	COG2207	Transcriptional regulator
MCU78_RS32835	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MCU78_RS32835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases