locus-tag	class	description
TK78_RS00015	COG4974	Belongs to the 'phage' integrase family
TK78_RS00185	COG3387	PFAM Glycoside hydrolase 15-related
TK78_RS00220	COG1309	transcriptional regulator
TK78_RS00235	COG2066	Belongs to the glutaminase family
TK78_RS00250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS00300	COG0069	glutamate synthase activity
TK78_RS00335	COG3293	Transposase
TK78_RS00355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TK78_RS00400	COG1070	Carbohydrate kinase
TK78_RS00425	COG4213	ABC transporter substrate-binding protein
TK78_RS00435	COG4214	carbohydrate transport
TK78_RS00450	COG1595	DNA-templated transcription, initiation
TK78_RS00470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TK78_RS00475	COG1175	transmembrane transport
TK78_RS00480	COG0395	ABC-type sugar transport system, permease component
TK78_RS00485	COG1609	Transcriptional regulator
TK78_RS00490	COG1874	Beta-galactosidase
TK78_RS00515	COG2226	methyltransferase
TK78_RS00530	COG0586	Pfam SNARE associated Golgi protein
TK78_RS00575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TK78_RS00580	COG0656	L-ascorbic acid biosynthetic process
TK78_RS00590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TK78_RS00595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS00600	COG0667	Aldo Keto reductase
TK78_RS00620	COG0745	RESPONSE REGULATOR receiver
TK78_RS00625	COG2205	protein histidine kinase activity
TK78_RS00655	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TK78_RS00660	COG0714	Associated with various cellular activities
TK78_RS00670	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS00675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TK78_RS00685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TK78_RS00690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK78_RS00695	COG0395	ABC-type sugar transport system, permease component
TK78_RS00725	COG2318	DinB family
TK78_RS00740	COG2723	6-phospho-beta-galactosidase activity
TK78_RS00815	COG0009	L-threonylcarbamoyladenylate synthase
TK78_RS00835	COG0488	(ABC) transporter
TK78_RS00855	COG0583	DNA-binding transcription factor activity
TK78_RS00890	COG2340	Cysteine-rich secretory protein family
TK78_RS00905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TK78_RS00910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TK78_RS00930	COG1024	Enoyl-CoA hydratase
TK78_RS00960	COG2018	Roadblock/LC7 domain
TK78_RS00975	COG0640	Transcriptional regulator
TK78_RS00980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TK78_RS00985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TK78_RS01015	COG3239	Fatty acid desaturase
TK78_RS01020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TK78_RS01040	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS01055	COG0667	Aldo Keto reductase
TK78_RS01095	COG0326	Molecular chaperone. Has ATPase activity
TK78_RS01120	COG1794	racemase activity, acting on amino acids and derivatives
TK78_RS01160	COG1408	metallophosphoesterase
TK78_RS01170	COG1960	acyl-CoA dehydrogenase activity
TK78_RS01175	COG0789	Transcriptional regulator
TK78_RS01200	COG1175	transmembrane transport
TK78_RS01210	COG1063	alcohol dehydrogenase
TK78_RS01230	COG4044	May play a role in the intracellular transport of hydrophobic ligands
TK78_RS01235	COG1132	(ABC) transporter
TK78_RS01255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK78_RS01270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS01285	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS01290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS01295	COG2375	cellular response to nickel ion
TK78_RS01305	COG0693	protein deglycase activity
TK78_RS01310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TK78_RS01325	COG1278	Cold shock
TK78_RS01365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TK78_RS01405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TK78_RS01405	COG1796	DNA polymerase
TK78_RS01490	COG0444	Belongs to the ABC transporter superfamily
TK78_RS01495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK78_RS01500	COG0601	transmembrane transport
TK78_RS01535	COG1960	acyl-CoA dehydrogenase activity
TK78_RS01540	COG1960	acyl-CoA dehydrogenase activity
TK78_RS01560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK78_RS01570	COG0656	L-ascorbic acid biosynthetic process
TK78_RS01610	COG0297	glycogen (starch) synthase activity
TK78_RS01610	COG0438	transferase activity, transferring glycosyl groups
TK78_RS01630	COG0726	polysaccharide deacetylase
TK78_RS01635	COG0438	transferase activity, transferring glycosyl groups
TK78_RS01655	COG2304	oxidoreductase activity
TK78_RS01680	COG1132	(ABC) transporter
TK78_RS01710	COG1120	ATPase activity
TK78_RS01715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS01720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS01735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TK78_RS01740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TK78_RS01745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TK78_RS01750	COG0254	rRNA binding
TK78_RS01760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TK78_RS01765	COG0477	Major facilitator Superfamily
TK78_RS01775	COG1120	ATPase activity
TK78_RS01790	COG3250	beta-galactosidase activity
TK78_RS01795	COG1070	Carbohydrate kinase
TK78_RS01800	COG3347	Dehydrogenase
TK78_RS01800	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS01805	COG4952	isomerase
TK78_RS01810	COG1129	ABC transporter
TK78_RS01815	COG1172	Belongs to the binding-protein-dependent transport system permease family
TK78_RS01830	COG1609	Transcriptional regulator
TK78_RS01860	COG1233	COG1233 Phytoene dehydrogenase and related
TK78_RS01885	COG0657	acetylesterase activity
TK78_RS01925	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS01950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TK78_RS01965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TK78_RS01975	COG1228	amidohydrolase
TK78_RS01985	COG1834	amidinotransferase
TK78_RS01990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TK78_RS02000	COG2045	Belongs to the ComB family
TK78_RS02010	COG1357	PFAM Pentapeptide repeats (8 copies)
TK78_RS02035	COG0714	Associated with various cellular activities
TK78_RS02060	COG2226	methyltransferase
TK78_RS02080	COG3335	DDE superfamily endonuclease
TK78_RS02105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TK78_RS02110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TK78_RS02120	COG1609	Transcriptional regulator
TK78_RS02135	COG3572	ergothioneine biosynthetic process
TK78_RS02140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TK78_RS02145	COG0121	glutamine amidotransferase
TK78_RS02150	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TK78_RS02165	COG1653	transport
TK78_RS02170	COG3360	Dodecin
TK78_RS02180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS02195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TK78_RS02200	COG1053	succinate dehydrogenase
TK78_RS02210	COG0583	DNA-binding transcription factor activity
TK78_RS02285	COG3275	phosphorelay sensor kinase activity
TK78_RS02290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK78_RS02310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TK78_RS02350	COG1191	sigma factor activity
TK78_RS02355	COG4566	intracellular signal transduction
TK78_RS02360	COG4251	negative regulation of phosphorylation
TK78_RS02365	COG0784	Response regulator, receiver
TK78_RS02385	COG2208	phosphoserine phosphatase activity
TK78_RS02415	COG1309	transcriptional regulator
TK78_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS02445	COG1175	transmembrane transport
TK78_RS02450	COG0395	ABC-type sugar transport system, permease component
TK78_RS02465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TK78_RS02495	COG1595	DNA-templated transcription, initiation
TK78_RS02505	COG1119	ATPase activity
TK78_RS02525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TK78_RS02530	COG2837	iron assimilation
TK78_RS02540	COG0019	diaminopimelate decarboxylase activity
TK78_RS02550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TK78_RS02560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TK78_RS02585	COG2188	Transcriptional regulator
TK78_RS02595	COG1175	transmembrane transport
TK78_RS02600	COG0395	ABC-type sugar transport system, permease component
TK78_RS02605	COG4948	Mandelate Racemase Muconate Lactonizing
TK78_RS02615	COG2130	NADP-dependent
TK78_RS02620	COG1233	COG1233 Phytoene dehydrogenase and related
TK78_RS02665	COG1846	Transcriptional regulator
TK78_RS02670	COG2409	Drug exporters of the RND superfamily
TK78_RS02685	COG1902	pentaerythritol trinitrate reductase activity
TK78_RS02685	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK78_RS02720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TK78_RS02790	COG4974	Belongs to the 'phage' integrase family
TK78_RS02835	COG1556	Lactate utilization protein
TK78_RS02840	COG1139	Iron-sulfur cluster binding protein
TK78_RS02845	COG0247	lactate metabolic process
TK78_RS02850	COG2186	Transcriptional regulator
TK78_RS02865	COG2197	response regulator
TK78_RS02875	COG3511	phospholipase C
TK78_RS02935	COG3959	Transketolase, thiamine diphosphate binding domain
TK78_RS02940	COG3958	Transketolase
TK78_RS02970	COG1116	anion transmembrane transporter activity
TK78_RS02980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK78_RS02985	COG1609	Transcriptional regulator
TK78_RS03045	COG0789	Transcriptional regulator
TK78_RS03055	COG3467	pyridoxamine 5'-phosphate
TK78_RS03095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TK78_RS03105	COG2755	lipolytic protein G-D-S-L family
TK78_RS03140	COG1657	PFAM Prenyltransferase squalene oxidase
TK78_RS03150	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TK78_RS03160	COG1562	ergosterol biosynthetic process
TK78_RS03165	COG1388	LysM domain
TK78_RS03165	COG1134	teichoic acid transport
TK78_RS03185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TK78_RS03210	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TK78_RS03225	COG1024	Enoyl-CoA hydratase
TK78_RS03235	COG4977	sequence-specific DNA binding
TK78_RS03250	COG2183	response to ionizing radiation
TK78_RS03260	COG0488	(ABC) transporter
TK78_RS03280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TK78_RS03310	COG0789	Transcriptional regulator
TK78_RS03315	COG1250	3-hydroxyacyl-CoA dehydrogenase
TK78_RS03315	COG1024	Enoyl-CoA hydratase
TK78_RS03320	COG0183	Belongs to the thiolase family
TK78_RS03325	COG1960	acyl-CoA dehydrogenase activity
TK78_RS03330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TK78_RS03335	COG3268	Saccharopine dehydrogenase
TK78_RS03345	COG1515	deoxyribonuclease V activity
TK78_RS03370	COG0488	(ABC) transporter
TK78_RS03380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TK78_RS03430	COG1793	dna ligase
TK78_RS03435	COG2326	polyphosphate kinase activity
TK78_RS03475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TK78_RS03500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TK78_RS03545	COG1960	acyl-CoA dehydrogenase activity
TK78_RS03570	COG3012	SEC-C Motif Domain Protein
TK78_RS03600	COG1486	melibiose metabolic process
TK78_RS03605	COG2124	cytochrome p450
TK78_RS03630	COG1846	Transcriptional regulator
TK78_RS03635	COG1289	transmembrane transporter activity
TK78_RS03655	COG1940	carbohydrate kinase activity
TK78_RS03665	COG1070	Carbohydrate kinase
TK78_RS03695	COG2124	cytochrome p450
TK78_RS03705	COG4176	ABC-type proline glycine betaine transport system permease component
TK78_RS03710	COG4175	Glycine betaine
TK78_RS03710	COG0517	IMP dehydrogenase activity
TK78_RS03720	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS03755	COG0745	RESPONSE REGULATOR receiver
TK78_RS03760	COG5002	protein histidine kinase activity
TK78_RS03775	COG3568	Endonuclease Exonuclease Phosphatase
TK78_RS03790	COG0714	Associated with various cellular activities
TK78_RS03800	COG1376	ErfK ybiS ycfS ynhG family protein
TK78_RS03810	COG0745	RESPONSE REGULATOR receiver
TK78_RS03815	COG2205	protein histidine kinase activity
TK78_RS03825	COG1869	D-ribose catabolic process
TK78_RS03830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK78_RS03840	COG1129	ABC transporter
TK78_RS03940	COG0673	inositol 2-dehydrogenase activity
TK78_RS03945	COG1879	ABC-type sugar transport system periplasmic component
TK78_RS03950	COG1172	Belongs to the binding-protein-dependent transport system permease family
TK78_RS03955	COG1129	ABC transporter
TK78_RS03965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TK78_RS03970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TK78_RS03995	COG0656	L-ascorbic acid biosynthetic process
TK78_RS04005	COG4106	trans-aconitate 2-methyltransferase activity
TK78_RS04015	COG0702	epimerase
TK78_RS04025	COG2154	pterin-4-alpha-carbinolamine dehydratase
TK78_RS04035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK78_RS04035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK78_RS04050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TK78_RS04105	COG0457	Tetratricopeptide repeat
TK78_RS04125	COG1619	proteins homologs of microcin C7 resistance protein MccF
TK78_RS04135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK78_RS04140	COG2362	D-Aminopeptidase
TK78_RS04160	COG0667	Aldo Keto reductase
TK78_RS04165	COG0583	DNA-binding transcription factor activity
TK78_RS04190	COG0596	Alpha beta hydrolase
TK78_RS04205	COG1250	3-hydroxyacyl-CoA dehydrogenase
TK78_RS04220	COG0604	alcohol dehydrogenase
TK78_RS04225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK78_RS04225	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK78_RS04230	COG2301	Belongs to the HpcH HpaI aldolase family
TK78_RS04240	COG1960	acyl-CoA dehydrogenase activity
TK78_RS04245	COG0688	phosphatidylethanolamine metabolic process
TK78_RS04275	COG0559	Belongs to the binding-protein-dependent transport system permease family
TK78_RS04300	COG1929	Belongs to the glycerate kinase type-1 family
TK78_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS04355	COG2072	flavoprotein involved in K transport
TK78_RS04390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TK78_RS04430	COG0531	amino acid
TK78_RS04440	COG5297	Belongs to the glycosyl hydrolase family 6
TK78_RS04440	COG4733	cellulase activity
TK78_RS04450	COG0366	Alpha amylase catalytic
TK78_RS04455	COG0395	ABC-type sugar transport system, permease component
TK78_RS04460	COG1175	transmembrane transport
TK78_RS04500	COG2233	PERMEase
TK78_RS04530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TK78_RS04550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TK78_RS04555	COG0477	Major facilitator Superfamily
TK78_RS04600	COG0095	Lipoate-protein ligase
TK78_RS04620	COG2838	Isocitrate dehydrogenase
TK78_RS04625	COG2205	protein histidine kinase activity
TK78_RS04635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TK78_RS04640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK78_RS04645	COG1191	sigma factor activity
TK78_RS04665	COG1953	Uracil, thiamine, allantoin
TK78_RS04675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TK78_RS04680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TK78_RS04720	COG0405	Gamma-glutamyltransferase
TK78_RS04740	COG0765	amino acid transport
TK78_RS04745	COG0765	amino acid transport
TK78_RS04750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TK78_RS04755	COG1126	abc transporter atp-binding protein
TK78_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS04780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TK78_RS04785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TK78_RS04800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TK78_RS04810	COG1940	carbohydrate kinase activity
TK78_RS04815	COG1129	ABC transporter
TK78_RS04825	COG1879	ABC-type sugar transport system periplasmic component
TK78_RS04830	COG2188	Transcriptional regulator
TK78_RS04835	COG0673	inositol 2-dehydrogenase activity
TK78_RS04845	COG2197	response regulator
TK78_RS04870	COG0656	L-ascorbic acid biosynthetic process
TK78_RS04875	COG4266	Belongs to the allantoicase family
TK78_RS04880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TK78_RS04885	COG1414	Transcriptional regulator
TK78_RS04905	COG2197	response regulator
TK78_RS04915	COG0746	molybdenum cofactor guanylyltransferase activity
TK78_RS04920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TK78_RS04925	COG0242	peptide deformylase activity
TK78_RS04970	COG2233	PERMEase
TK78_RS04980	COG2233	PERMEase
TK78_RS04990	COG2351	hydroxyisourate hydrolase activity
TK78_RS05010	COG2706	6-phosphogluconolactonase activity
TK78_RS05015	COG2188	Transcriptional regulator
TK78_RS05025	COG1175	transmembrane transport
TK78_RS05030	COG0395	ABC-type sugar transport system, permease component
TK78_RS05035	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TK78_RS05040	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TK78_RS05045	COG3622	Belongs to the hyi family
TK78_RS05050	COG2084	Dehydrogenase
TK78_RS05055	COG0753	catalase activity
TK78_RS05065	COG3960	tartronate-semialdehyde synthase activity
TK78_RS05085	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS05090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TK78_RS05095	COG2197	response regulator
TK78_RS05110	COG0435	Glutathione S-transferase
TK78_RS05125	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS05130	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TK78_RS05145	COG0640	Transcriptional regulator
TK78_RS05155	COG0667	Aldo Keto reductase
TK78_RS05165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS05170	COG1116	anion transmembrane transporter activity
TK78_RS05180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TK78_RS05205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TK78_RS05255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TK78_RS05255	COG3608	succinylglutamate desuccinylase aspartoacylase
TK78_RS05260	COG2252	PERMEase
TK78_RS05265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TK78_RS05290	COG1802	Transcriptional regulator
TK78_RS05320	COG0028	Belongs to the TPP enzyme family
TK78_RS05350	COG1162	GTPase activity
TK78_RS05400	COG0183	Belongs to the thiolase family
TK78_RS05405	COG0583	DNA-binding transcription factor activity
TK78_RS05410	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TK78_RS05415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TK78_RS05420	COG1250	3-hydroxyacyl-CoA dehydrogenase
TK78_RS05440	COG1960	acyl-CoA dehydrogenase activity
TK78_RS05455	COG1191	sigma factor activity
TK78_RS05480	COG0175	sulfate reduction
TK78_RS05485	COG0529	Catalyzes the synthesis of activated sulfate
TK78_RS05505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TK78_RS05510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK78_RS05525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TK78_RS05535	COG1120	ATPase activity
TK78_RS05540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS05545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS05550	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TK78_RS05555	COG1132	(ABC) transporter
TK78_RS05560	COG1132	(ABC) transporter
TK78_RS05580	COG1404	Belongs to the peptidase S8 family
TK78_RS05600	COG1175	transmembrane transport
TK78_RS05640	COG0583	DNA-binding transcription factor activity
TK78_RS05645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TK78_RS05675	COG2723	6-phospho-beta-galactosidase activity
TK78_RS05690	COG1072	(Pantothenic acid kinase))
TK78_RS05695	COG0346	lactoylglutathione lyase activity
TK78_RS05705	COG0477	Major facilitator Superfamily
TK78_RS05715	COG0583	DNA-binding transcription factor activity
TK78_RS05720	COG0156	8-amino-7-oxononanoate synthase activity
TK78_RS05725	COG1063	alcohol dehydrogenase
TK78_RS05735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK78_RS05735	COG0515	serine threonine protein kinase
TK78_RS05740	COG0515	serine threonine protein kinase
TK78_RS05740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK78_RS05750	COG2267	carboxylic ester hydrolase activity
TK78_RS05815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK78_RS05820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TK78_RS05875	COG3220	belongs to the UPF0276 family
TK78_RS05890	COG3253	May function as heme-dependent peroxidase
TK78_RS05895	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TK78_RS05905	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK78_RS05910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TK78_RS05935	COG0183	Belongs to the thiolase family
TK78_RS05940	COG1250	3-hydroxyacyl-CoA dehydrogenase
TK78_RS05940	COG1024	Enoyl-CoA hydratase
TK78_RS05950	COG0438	transferase activity, transferring glycosyl groups
TK78_RS05960	COG0438	transferase activity, transferring glycosyl groups
TK78_RS05975	COG1316	TRANSCRIPTIONal
TK78_RS05985	COG0531	amino acid
TK78_RS05990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TK78_RS05995	COG4214	carbohydrate transport
TK78_RS06005	COG4213	ABC transporter substrate-binding protein
TK78_RS06010	COG1940	carbohydrate kinase activity
TK78_RS06015	COG0395	ABC-type sugar transport system, permease component
TK78_RS06020	COG1175	transmembrane transport
TK78_RS06025	COG1653	transport
TK78_RS06035	COG0588	phosphoglycerate mutase activity
TK78_RS06045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TK78_RS06060	COG1742	UPF0060 membrane protein
TK78_RS06085	COG3548	integral membrane protein
TK78_RS06090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TK78_RS06100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TK78_RS06105	COG0456	acetyltransferase
TK78_RS06105	COG3153	acetyltransferase
TK78_RS06165	COG2319	Wd-40 repeat
TK78_RS06175	COG2319	Wd-40 repeat
TK78_RS06220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TK78_RS06240	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS06260	COG2172	sigma factor antagonist activity
TK78_RS06260	COG1366	Belongs to the anti-sigma-factor antagonist family
TK78_RS06260	COG2208	phosphoserine phosphatase activity
TK78_RS06275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TK78_RS06280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK78_RS06285	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TK78_RS06305	COG0438	transferase activity, transferring glycosyl groups
TK78_RS06320	COG0489	protein tyrosine kinase activity
TK78_RS06325	COG0297	glycogen (starch) synthase activity
TK78_RS06355	COG0651	ATP synthesis coupled electron transport
TK78_RS06360	COG1006	Multisubunit Na H antiporter MnhC subunit
TK78_RS06365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TK78_RS06365	COG2111	Na H antiporter
TK78_RS06410	COG1024	Enoyl-CoA hydratase
TK78_RS06420	COG0531	amino acid
TK78_RS06425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TK78_RS06435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TK78_RS06445	COG2040	homocysteine
TK78_RS06465	COG1799	cell septum assembly
TK78_RS06470	COG1349	DNA-binding transcription factor activity
TK78_RS06475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TK78_RS06480	COG0586	Pfam SNARE associated Golgi protein
TK78_RS06490	COG3467	pyridoxamine 5'-phosphate
TK78_RS06495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS06500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS06540	COG3046	protein related to deoxyribodipyrimidine photolyase
TK78_RS06545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TK78_RS06550	COG1280	lysine exporter protein (LysE YggA)
TK78_RS06560	COG3291	Pkd domain containing protein
TK78_RS06565	COG4608	Belongs to the ABC transporter superfamily
TK78_RS06575	COG0601	transmembrane transport
TK78_RS06580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK78_RS06590	COG0006	proline dipeptidase activity
TK78_RS06595	COG1802	Transcriptional regulator
TK78_RS06600	COG2423	ornithine cyclodeaminase activity
TK78_RS06610	COG3938	Belongs to the proline racemase family
TK78_RS06620	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK78_RS06630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TK78_RS06640	COG2957	Belongs to the agmatine deiminase family
TK78_RS06655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK78_RS06665	COG0747	negative chemotaxis
TK78_RS06670	COG2957	Belongs to the agmatine deiminase family
TK78_RS06675	COG0832	Belongs to the urease beta subunit family
TK78_RS06675	COG0831	urea catabolic process
TK78_RS06685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK78_RS06685	COG0515	serine threonine protein kinase
TK78_RS06690	COG1309	transcriptional regulator
TK78_RS06695	COG2957	Belongs to the agmatine deiminase family
TK78_RS06705	COG2843	Capsule synthesis protein
TK78_RS06735	COG4152	abc transporter atp-binding protein
TK78_RS06765	COG2124	cytochrome p450
TK78_RS06845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TK78_RS06850	COG0531	amino acid
TK78_RS06855	COG0569	domain protein
TK78_RS06885	COG1136	(ABC) transporter
TK78_RS06885	COG4591	ABC-type transport system involved in lipoprotein release permease component
TK78_RS06895	COG0756	dUTP diphosphatase activity
TK78_RS06920	COG2205	protein histidine kinase activity
TK78_RS06925	COG0745	RESPONSE REGULATOR receiver
TK78_RS06935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TK78_RS06970	COG1278	Cold shock
TK78_RS06975	COG0577	efflux transmembrane transporter activity
TK78_RS06975	COG1136	(ABC) transporter
TK78_RS07040	COG2267	carboxylic ester hydrolase activity
TK78_RS07045	COG1509	lysine 2,3-aminomutase activity
TK78_RS07060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS07070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS07080	COG3321	synthase
TK78_RS07080	COG0604	alcohol dehydrogenase
TK78_RS07100	COG1309	transcriptional regulator
TK78_RS07105	COG0604	alcohol dehydrogenase
TK78_RS07105	COG3321	synthase
TK78_RS07130	COG0604	alcohol dehydrogenase
TK78_RS07135	COG3321	synthase
TK78_RS07135	COG0604	alcohol dehydrogenase
TK78_RS07160	COG1435	thymidine kinase activity
TK78_RS07175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TK78_RS07175	COG0045	succinate-CoA ligase (ADP-forming) activity
TK78_RS07175	COG1042	CoA-binding domain protein
TK78_RS07180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TK78_RS07185	COG1802	Transcriptional regulator
TK78_RS07200	COG0612	Peptidase, M16
TK78_RS07205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TK78_RS07215	COG0372	Belongs to the citrate synthase family
TK78_RS07220	COG0372	Belongs to the citrate synthase family
TK78_RS07230	COG3290	protein histidine kinase activity
TK78_RS07235	COG4565	transcriptional regulatory protein
TK78_RS07240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK78_RS07265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TK78_RS07270	COG2186	Transcriptional regulator
TK78_RS07305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TK78_RS07320	COG0406	alpha-ribazole phosphatase activity
TK78_RS07340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK78_RS07345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TK78_RS07350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TK78_RS07390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TK78_RS07400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TK78_RS07405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TK78_RS07415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TK78_RS07430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TK78_RS07440	COG2205	protein histidine kinase activity
TK78_RS07445	COG0745	RESPONSE REGULATOR receiver
TK78_RS07450	COG1126	abc transporter atp-binding protein
TK78_RS07455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TK78_RS07460	COG0765	amino acid transport
TK78_RS07465	COG0765	amino acid transport
TK78_RS07470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TK78_RS07480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK78_RS07495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TK78_RS07535	COG2207	Transcriptional regulator
TK78_RS07535	COG1917	Cupin 2, conserved barrel domain protein
TK78_RS07540	COG1201	RNA secondary structure unwinding
TK78_RS07545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TK78_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS07565	COG0783	Belongs to the Dps family
TK78_RS07570	COG1396	sequence-specific DNA binding
TK78_RS07575	COG1058	Belongs to the CinA family
TK78_RS07575	COG1546	Belongs to the CinA family
TK78_RS07585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TK78_RS07595	COG1674	ftsk spoiiie
TK78_RS07605	COG4999	Histidine kinase
TK78_RS07605	COG3850	Histidine kinase
TK78_RS07605	COG3437	response regulator, receiver
TK78_RS07605	COG2205	protein histidine kinase activity
TK78_RS07610	COG2208	phosphoserine phosphatase activity
TK78_RS07610	COG2770	Histidine kinase
TK78_RS07635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TK78_RS07640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TK78_RS07645	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TK78_RS07665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TK78_RS07670	COG0612	Peptidase, M16
TK78_RS07675	COG1185	polyribonucleotide nucleotidyltransferase activity
TK78_RS07680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TK78_RS07690	COG1674	ftsk spoiiie
TK78_RS07705	COG1404	Belongs to the peptidase S8 family
TK78_RS07720	COG1404	Belongs to the peptidase S8 family
TK78_RS07725	COG3266	domain, Protein
TK78_RS07745	COG0455	bacterial-type flagellum organization
TK78_RS07750	COG0747	negative chemotaxis
TK78_RS07755	COG0601	transmembrane transport
TK78_RS07760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK78_RS07805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TK78_RS07810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TK78_RS07820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TK78_RS07835	COG0779	Required for maturation of 30S ribosomal subunits
TK78_RS07855	COG0442	prolyl-tRNA aminoacylation
TK78_RS07870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TK78_RS07875	COG0750	zinc metalloprotease
TK78_RS07880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TK78_RS07885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TK78_RS07895	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS07900	COG2508	Transcriptional regulator
TK78_RS07930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TK78_RS07935	COG1177	transmembrane transport
TK78_RS07940	COG1176	ABC-type spermidine putrescine transport system, permease component I
TK78_RS07945	COG3842	ATPase activity
TK78_RS07950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TK78_RS07970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TK78_RS07995	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS08005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TK78_RS08035	COG4585	Histidine kinase
TK78_RS08040	COG2197	response regulator
TK78_RS08045	COG3842	ATPase activity
TK78_RS08060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TK78_RS08065	COG0575	Belongs to the CDS family
TK78_RS08070	COG0233	cytoplasmic translational termination
TK78_RS08075	COG0528	UMP kinase activity
TK78_RS08080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TK78_RS08085	COG0052	Belongs to the universal ribosomal protein uS2 family
TK78_RS08100	COG1191	sigma factor activity
TK78_RS08115	COG0792	nuclease activity
TK78_RS08130	COG0681	Belongs to the peptidase S26 family
TK78_RS08135	COG0681	Belongs to the peptidase S26 family
TK78_RS08140	COG0681	Belongs to the peptidase S26 family
TK78_RS08150	COG0335	large ribosomal subunit rRNA binding
TK78_RS08155	COG0336	Belongs to the RNA methyltransferase TrmD family
TK78_RS08160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TK78_RS08165	COG1837	Belongs to the UPF0109 family
TK78_RS08170	COG0228	four-way junction DNA binding
TK78_RS08190	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TK78_RS08225	COG0477	Major facilitator Superfamily
TK78_RS08230	COG1196	nuclear chromosome segregation
TK78_RS08245	COG1254	Belongs to the acylphosphatase family
TK78_RS08250	COG2340	Cysteine-rich secretory protein family
TK78_RS08255	COG1733	regulation of RNA biosynthetic process
TK78_RS08260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TK78_RS08265	COG0571	ribonuclease III activity
TK78_RS08270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TK78_RS08285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TK78_RS08290	COG0742	ribosomal rna small subunit methyltransferase
TK78_RS08295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TK78_RS08300	COG1461	Dihydroxyacetone kinase
TK78_RS08305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TK78_RS08310	COG0351	phosphomethylpyrimidine kinase
TK78_RS08330	COG1181	Belongs to the D-alanine--D-alanine ligase family
TK78_RS08335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TK78_RS08350	COG0776	regulation of translation
TK78_RS08360	COG0066	3-isopropylmalate dehydratase activity
TK78_RS08365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TK78_RS08370	COG1414	Transcriptional regulator
TK78_RS08415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TK78_RS08420	COG0179	Fumarylacetoacetate (FAA) hydrolase
TK78_RS08430	COG5002	protein histidine kinase activity
TK78_RS08435	COG2018	Roadblock/LC7 domain
TK78_RS08455	COG2018	Roadblock/LC7 domain
TK78_RS08475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TK78_RS08480	COG0366	Alpha amylase catalytic
TK78_RS08480	COG1470	cell adhesion involved in biofilm formation
TK78_RS08500	COG2353	YceI-like domain
TK78_RS08505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK78_RS08510	COG1120	ATPase activity
TK78_RS08515	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS08520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS08545	COG0494	nUDIX hydrolase
TK78_RS08565	COG3634	alkyl hydroperoxide reductase activity
TK78_RS08590	COG2207	Transcriptional regulator
TK78_RS08590	COG3708	Transcriptional regulator
TK78_RS08595	COG2084	Dehydrogenase
TK78_RS08600	COG1309	transcriptional regulator
TK78_RS08630	COG1472	Belongs to the glycosyl hydrolase 3 family
TK78_RS08640	COG0444	Belongs to the ABC transporter superfamily
TK78_RS08645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK78_RS08650	COG0601	transmembrane transport
TK78_RS08655	COG4608	Belongs to the ABC transporter superfamily
TK78_RS08665	COG1609	Transcriptional regulator
TK78_RS08670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TK78_RS08685	COG2957	Belongs to the agmatine deiminase family
TK78_RS08690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TK78_RS08695	COG0473	3-isopropylmalate dehydrogenase activity
TK78_RS08710	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS08715	COG0506	proline dehydrogenase activity
TK78_RS08720	COG2508	Transcriptional regulator
TK78_RS08740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TK78_RS08765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TK78_RS08770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TK78_RS08775	COG0440	acetolactate synthase activity
TK78_RS08785	COG3300	MHYT domain
TK78_RS08785	COG5001	Diguanylate cyclase
TK78_RS08795	COG0667	Aldo Keto reductase
TK78_RS08800	COG2133	pyrroloquinoline quinone binding
TK78_RS08810	COG2197	response regulator
TK78_RS08825	COG2409	Drug exporters of the RND superfamily
TK78_RS08835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TK78_RS08840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TK78_RS08850	COG0154	amidase activity
TK78_RS08855	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TK78_RS08865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TK78_RS08875	COG4221	oxidoreductase activity
TK78_RS08895	COG0482	sulfurtransferase activity
TK78_RS08930	COG2860	membrane
TK78_RS08935	COG4608	Belongs to the ABC transporter superfamily
TK78_RS08945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK78_RS08950	COG0601	transmembrane transport
TK78_RS08955	COG0747	negative chemotaxis
TK78_RS08975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TK78_RS08980	COG0509	glycine decarboxylation via glycine cleavage system
TK78_RS08985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TK78_RS08990	COG1760	l-serine dehydratase
TK78_RS08995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS08995	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
TK78_RS09000	COG0736	holo-[acyl-carrier-protein] synthase activity
TK78_RS09025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TK78_RS09035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TK78_RS09040	COG0019	diaminopimelate decarboxylase activity
TK78_RS09045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TK78_RS09050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TK78_RS09060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TK78_RS09075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TK78_RS09090	COG4566	intracellular signal transduction
TK78_RS09100	COG0747	negative chemotaxis
TK78_RS09115	COG2235	arginine
TK78_RS09120	COG0464	growth
TK78_RS09130	COG0823	Involved in the tonB-independent uptake of proteins
TK78_RS09130	COG1506	peptidase
TK78_RS09265	COG2197	response regulator
TK78_RS09285	COG1132	(ABC) transporter
TK78_RS09290	COG1132	(ABC) transporter
TK78_RS09295	COG1597	lipid kinase activity
TK78_RS09335	COG0058	SHG alpha-glucan phosphorylase activity
TK78_RS09340	COG0366	Alpha amylase catalytic
TK78_RS09345	COG0366	Alpha amylase catalytic
TK78_RS09350	COG3281	Trehalose synthase
TK78_RS09355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TK78_RS09370	COG1301	dicarboxylic acid transport
TK78_RS09375	COG3290	protein histidine kinase activity
TK78_RS09380	COG4565	transcriptional regulatory protein
TK78_RS09390	COG0205	6-phosphofructokinase activity
TK78_RS09395	COG0280	phosphate acetyltransferase
TK78_RS09395	COG0857	belongs to the CobB CobQ family
TK78_RS09400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TK78_RS09440	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TK78_RS09445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK78_RS09445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK78_RS09480	COG1595	DNA-templated transcription, initiation
TK78_RS09525	COG5002	protein histidine kinase activity
TK78_RS09525	COG5000	phosphorelay sensor kinase activity
TK78_RS09530	COG0745	RESPONSE REGULATOR receiver
TK78_RS09545	COG0183	Belongs to the thiolase family
TK78_RS09565	COG1131	(ABC) transporter
TK78_RS09600	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TK78_RS09615	COG1250	3-hydroxyacyl-CoA dehydrogenase
TK78_RS09645	COG4585	Histidine kinase
TK78_RS09650	COG2197	response regulator
TK78_RS09665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TK78_RS09670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TK78_RS09675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TK78_RS09680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TK78_RS09685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TK78_RS09690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TK78_RS09695	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TK78_RS09715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TK78_RS09720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TK78_RS09730	COG2890	protein-(glutamine-N5) methyltransferase activity
TK78_RS09735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TK78_RS09740	COG0254	rRNA binding
TK78_RS09745	COG1316	TRANSCRIPTIONal
TK78_RS09760	COG0083	homoserine kinase activity
TK78_RS09765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TK78_RS09770	COG0460	homoserine dehydrogenase
TK78_RS09775	COG0019	diaminopimelate decarboxylase activity
TK78_RS09780	COG0018	arginyl-trna synthetase
TK78_RS09820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TK78_RS09825	COG3629	intracellular signal transduction
TK78_RS09825	COG3903	Transcriptional regulator
TK78_RS09840	COG3629	intracellular signal transduction
TK78_RS09840	COG3903	Transcriptional regulator
TK78_RS09855	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TK78_RS09860	COG1793	dna ligase
TK78_RS09860	COG3285	dna ligase
TK78_RS09880	COG2205	protein histidine kinase activity
TK78_RS09895	COG0768	penicillin binding
TK78_RS09900	COG0154	amidase activity
TK78_RS09920	COG1309	transcriptional regulator
TK78_RS09960	COG5002	protein histidine kinase activity
TK78_RS09975	COG0726	polysaccharide deacetylase
TK78_RS09980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TK78_RS09990	COG0745	RESPONSE REGULATOR receiver
TK78_RS09995	COG2205	protein histidine kinase activity
TK78_RS10005	COG0567	Dehydrogenase, E1 component
TK78_RS10005	COG0508	dehydrogenase complex catalyzes the overall conversion of
TK78_RS10030	COG0542	response to heat
TK78_RS10050	COG0604	alcohol dehydrogenase
TK78_RS10055	COG0281	malic enzyme
TK78_RS10060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TK78_RS10065	COG0765	amino acid transport
TK78_RS10070	COG1126	abc transporter atp-binding protein
TK78_RS10075	COG4106	trans-aconitate 2-methyltransferase activity
TK78_RS10100	COG0659	secondary active sulfate transmembrane transporter activity
TK78_RS10135	COG4585	Histidine kinase
TK78_RS10140	COG2197	response regulator
TK78_RS10205	COG0142	geranyltranstransferase activity
TK78_RS10210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TK78_RS10215	COG1959	2 iron, 2 sulfur cluster binding
TK78_RS10225	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TK78_RS10240	COG2172	sigma factor antagonist activity
TK78_RS10255	COG1597	lipid kinase activity
TK78_RS10270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TK78_RS10275	COG0363	glucosamine-6-phosphate deaminase activity
TK78_RS10280	COG1472	Belongs to the glycosyl hydrolase 3 family
TK78_RS10285	COG0395	ABC-type sugar transport system, permease component
TK78_RS10290	COG1175	transmembrane transport
TK78_RS10295	COG2182	Extracellular solute-binding protein
TK78_RS10305	COG1966	Carbon starvation protein
TK78_RS10335	COG1131	(ABC) transporter
TK78_RS10360	COG0242	peptide deformylase activity
TK78_RS10380	COG5662	AntiSigma factor
TK78_RS10385	COG1595	DNA-templated transcription, initiation
TK78_RS10395	COG2135	peptidase activity
TK78_RS10405	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TK78_RS10415	COG1181	Belongs to the D-alanine--D-alanine ligase family
TK78_RS10425	COG1181	Belongs to the D-alanine--D-alanine ligase family
TK78_RS10435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TK78_RS10440	COG1181	Belongs to the D-alanine--D-alanine ligase family
TK78_RS10450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TK78_RS10455	COG1162	GTPase activity
TK78_RS10460	COG2076	Multidrug Resistance protein
TK78_RS10470	COG0483	inositol monophosphate 1-phosphatase activity
TK78_RS10480	COG0753	catalase activity
TK78_RS10505	COG1615	UPF0182 protein
TK78_RS10515	COG3480	Lon protease (S16) C-terminal proteolytic domain
TK78_RS10565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TK78_RS10605	COG0210	DNA helicase
TK78_RS10695	COG0513	Belongs to the DEAD box helicase family
TK78_RS10705	COG1432	Conserved Protein
TK78_RS10710	COG2095	MarC family integral membrane protein
TK78_RS10715	COG0613	PHP domain protein
TK78_RS10725	COG2814	Major facilitator Superfamily
TK78_RS10735	COG0598	Magnesium transport protein CorA
TK78_RS10770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TK78_RS10775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK78_RS10785	COG1595	DNA-templated transcription, initiation
TK78_RS10800	COG1024	Enoyl-CoA hydratase
TK78_RS10805	COG0519	Catalyzes the synthesis of GMP from XMP
TK78_RS10815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TK78_RS10825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK78_RS10855	COG2912	Transglutaminase-like superfamily
TK78_RS10860	COG2197	response regulator
TK78_RS10865	COG1132	(ABC) transporter
TK78_RS10870	COG1132	(ABC) transporter
TK78_RS10880	COG0515	serine threonine protein kinase
TK78_RS10895	COG0110	maltose O-acetyltransferase activity
TK78_RS10930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TK78_RS10950	COG4608	Belongs to the ABC transporter superfamily
TK78_RS10955	COG0444	Belongs to the ABC transporter superfamily
TK78_RS10960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK78_RS10965	COG0601	transmembrane transport
TK78_RS10970	COG4166	transmembrane transport
TK78_RS10975	COG4608	Belongs to the ABC transporter superfamily
TK78_RS10985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK78_RS10990	COG0601	transmembrane transport
TK78_RS10995	COG4166	transmembrane transport
TK78_RS11000	COG1217	gtp-binding protein TYPA
TK78_RS11030	COG1175	transmembrane transport
TK78_RS11035	COG0395	ABC-type sugar transport system, permease component
TK78_RS11060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TK78_RS11120	COG3631	Ketosteroid isomerase-related protein
TK78_RS11125	COG0702	epimerase
TK78_RS11150	COG2770	Histidine kinase
TK78_RS11150	COG2208	phosphoserine phosphatase activity
TK78_RS11195	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS11230	COG0463	Glycosyl transferase, family 2
TK78_RS11240	COG1842	Phage shock protein A
TK78_RS11335	COG0012	GTP binding
TK78_RS11350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TK78_RS11360	COG1570	exodeoxyribonuclease VII activity
TK78_RS11365	COG1722	exodeoxyribonuclease VII activity
TK78_RS11370	COG0778	Nitroreductase
TK78_RS11395	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TK78_RS11395	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TK78_RS11410	COG3321	synthase
TK78_RS11410	COG0604	alcohol dehydrogenase
TK78_RS11420	COG1362	aminopeptidase activity
TK78_RS11435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS11445	COG0114	fumarate hydratase activity
TK78_RS11460	COG4499	WXG100 protein secretion system (Wss), protein YukC
TK78_RS11460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TK78_RS11480	COG1136	(ABC) transporter
TK78_RS11495	COG0450	alkyl hydroperoxide reductase
TK78_RS11500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TK78_RS11515	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TK78_RS11520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TK78_RS11525	COG0667	Aldo Keto reductase
TK78_RS11585	COG2885	chlorophyll binding
TK78_RS11605	COG2197	response regulator
TK78_RS11610	COG3920	Histidine kinase
TK78_RS11640	COG2894	cell division
TK78_RS11670	COG2610	gluconate transmembrane transporter activity
TK78_RS11675	COG0251	oxidation-reduction process
TK78_RS11680	COG1414	Transcriptional regulator
TK78_RS11695	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TK78_RS11715	COG1733	regulation of RNA biosynthetic process
TK78_RS11735	COG0436	Aminotransferase
TK78_RS11765	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TK78_RS11775	COG1331	Highly conserved protein containing a thioredoxin domain
TK78_RS11785	COG1309	transcriptional regulator
TK78_RS11790	COG0154	amidase activity
TK78_RS11825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TK78_RS11835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TK78_RS11850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TK78_RS11855	COG2255	four-way junction helicase activity
TK78_RS11860	COG1595	DNA-templated transcription, initiation
TK78_RS11890	COG0583	DNA-binding transcription factor activity
TK78_RS11895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK78_RS11910	COG1396	sequence-specific DNA binding
TK78_RS11920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TK78_RS11940	COG1376	ErfK ybiS ycfS ynhG family protein
TK78_RS11965	COG1024	Enoyl-CoA hydratase
TK78_RS11980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TK78_RS11990	COG0424	maF-like protein
TK78_RS12000	COG4770	biotin carboxylase activity
TK78_RS12040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK78_RS12055	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS12060	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS12080	COG1595	DNA-templated transcription, initiation
TK78_RS12085	COG0745	RESPONSE REGULATOR receiver
TK78_RS12090	COG2205	protein histidine kinase activity
TK78_RS12115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TK78_RS12130	COG0583	DNA-binding transcription factor activity
TK78_RS12135	COG2814	Major facilitator Superfamily
TK78_RS12155	COG1404	Belongs to the peptidase S8 family
TK78_RS12175	COG1079	Belongs to the binding-protein-dependent transport system permease family
TK78_RS12180	COG4603	Belongs to the binding-protein-dependent transport system permease family
TK78_RS12185	COG3845	ABC transporter
TK78_RS12190	COG1744	ABC transporter substrate-binding protein PnrA-like
TK78_RS12195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TK78_RS12195	COG1473	amidohydrolase
TK78_RS12205	COG2089	acid synthase
TK78_RS12210	COG1083	cytidylyl-transferase
TK78_RS12220	COG1216	Glycosyl transferase, family 2
TK78_RS12250	COG1216	Glycosyl transferase, family 2
TK78_RS12275	COG1595	DNA-templated transcription, initiation
TK78_RS12280	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TK78_RS12285	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TK78_RS12290	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TK78_RS12345	COG2009	succinate dehydrogenase
TK78_RS12355	COG1053	succinate dehydrogenase
TK78_RS12360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TK78_RS12395	COG1408	metallophosphoesterase
TK78_RS12405	COG1686	Belongs to the peptidase S11 family
TK78_RS12410	COG1295	ribonuclease BN
TK78_RS12430	COG0180	Tryptophanyl-tRNA synthetase
TK78_RS12435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TK78_RS12440	COG0754	glutathionylspermidine amidase activity
TK78_RS12450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TK78_RS12455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TK78_RS12460	COG0039	L-malate dehydrogenase activity
TK78_RS12475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TK78_RS12490	COG0138	bifunctional purine biosynthesis protein purh
TK78_RS12520	COG0045	succinate-CoA ligase (ADP-forming) activity
TK78_RS12535	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TK78_RS12545	COG0714	Associated with various cellular activities
TK78_RS12565	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK78_RS12575	COG0739	heme binding
TK78_RS12600	COG2197	response regulator
TK78_RS12645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TK78_RS12645	COG0519	Catalyzes the synthesis of GMP from XMP
TK78_RS12665	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS12675	COG0515	serine threonine protein kinase
TK78_RS12705	COG0516	GMP reductase activity
TK78_RS12715	COG1595	DNA-templated transcription, initiation
TK78_RS12730	COG0583	DNA-binding transcription factor activity
TK78_RS12745	COG2132	Multicopper oxidase
TK78_RS12755	COG1609	Transcriptional regulator
TK78_RS12770	COG0395	ABC-type sugar transport system, permease component
TK78_RS12790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TK78_RS12800	COG0726	polysaccharide deacetylase
TK78_RS12825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TK78_RS12850	COG0802	atpase or kinase
TK78_RS12860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TK78_RS12865	COG3189	MarR family transcriptional regulator
TK78_RS12870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TK78_RS12870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TK78_RS12875	COG0736	holo-[acyl-carrier-protein] synthase activity
TK78_RS12880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TK78_RS12910	COG0596	Alpha beta hydrolase
TK78_RS12925	COG4941	Belongs to the sigma-70 factor family
TK78_RS12930	COG3795	YCII-related domain
TK78_RS12975	COG1072	(Pantothenic acid kinase))
TK78_RS12985	COG2208	phosphoserine phosphatase activity
TK78_RS12985	COG2770	Histidine kinase
TK78_RS12990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK78_RS12995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TK78_RS13000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TK78_RS13005	COG0488	(ABC) transporter
TK78_RS13015	COG0101	tRNA pseudouridine synthase activity
TK78_RS13020	COG0203	ribosomal protein L17
TK78_RS13025	COG0202	RNA polymerase activity
TK78_RS13030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TK78_RS13035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TK78_RS13040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TK78_RS13045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TK78_RS13055	COG0563	adenylate kinase activity
TK78_RS13065	COG0200	Binds to the 23S rRNA
TK78_RS13070	COG1841	ribosomal large subunit assembly
TK78_RS13075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TK78_RS13080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TK78_RS13085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TK78_RS13090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TK78_RS13100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TK78_RS13105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TK78_RS13110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TK78_RS13115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TK78_RS13120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TK78_RS13125	COG0255	Belongs to the universal ribosomal protein uL29 family
TK78_RS13130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TK78_RS13135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TK78_RS13140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TK78_RS13145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TK78_RS13150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TK78_RS13155	COG0089	rRNA binding
TK78_RS13160	COG0088	Forms part of the polypeptide exit tunnel
TK78_RS13165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TK78_RS13170	COG0051	transcription antitermination factor activity, RNA binding
TK78_RS13195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TK78_RS13200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TK78_RS13205	COG0049	tRNA binding
TK78_RS13210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TK78_RS13220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TK78_RS13225	COG0085	RNA polymerase activity
TK78_RS13235	COG0222	ribosome binding
TK78_RS13240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TK78_RS13250	COG0081	regulation of translation
TK78_RS13255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TK78_RS13275	COG0436	Aminotransferase
TK78_RS13280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TK78_RS13295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TK78_RS13300	COG2814	Major facilitator Superfamily
TK78_RS13310	COG2030	dehydratase
TK78_RS13315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TK78_RS13335	COG0702	epimerase
TK78_RS13345	COG1666	GTP binding
TK78_RS13350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TK78_RS13365	COG3304	Inner membrane component domain
TK78_RS13370	COG0501	Belongs to the peptidase M48B family
TK78_RS13380	COG1007	ATP synthesis coupled electron transport
TK78_RS13395	COG0713	ATP synthesis coupled electron transport
TK78_RS13400	COG0839	Belongs to the complex I subunit 6 family
TK78_RS13405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK78_RS13410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TK78_RS13415	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK78_RS13420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK78_RS13425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK78_RS13445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TK78_RS13445	COG0674	pyruvate-flavodoxin oxidoreductase activity
TK78_RS13450	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK78_RS13455	COG0702	epimerase
TK78_RS13505	COG0561	phosphatase activity
TK78_RS13525	COG3903	Transcriptional regulator
TK78_RS13525	COG3629	intracellular signal transduction
TK78_RS13540	COG1131	(ABC) transporter
TK78_RS13550	COG0142	geranyltranstransferase activity
TK78_RS13555	COG3104	oligopeptide transport
TK78_RS13565	COG0179	Fumarylacetoacetate (FAA) hydrolase
TK78_RS13575	COG2197	response regulator
TK78_RS13585	COG0596	Alpha beta hydrolase
TK78_RS13595	COG0514	ATP-dependent DNA helicase (RecQ)
TK78_RS13600	COG1007	ATP synthesis coupled electron transport
TK78_RS13610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TK78_RS13615	COG0713	ATP synthesis coupled electron transport
TK78_RS13620	COG0839	Belongs to the complex I subunit 6 family
TK78_RS13625	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK78_RS13630	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TK78_RS13635	COG1034	ATP synthesis coupled electron transport
TK78_RS13640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TK78_RS13650	COG0649	NAD binding
TK78_RS13655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK78_RS13660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK78_RS13705	COG2226	methyltransferase
TK78_RS13710	COG2175	clavaminate synthase activity
TK78_RS13720	COG4521	taurine ABC transporter
TK78_RS13725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK78_RS13745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TK78_RS13755	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TK78_RS13760	COG1278	Cold shock
TK78_RS13825	COG1309	transcriptional regulator
TK78_RS13835	COG1960	acyl-CoA dehydrogenase activity
TK78_RS13850	COG0259	pyridoxamine-phosphate oxidase activity
TK78_RS13855	COG0501	Belongs to the peptidase M48B family
TK78_RS13885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS13890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS13895	COG4592	Periplasmic binding protein
TK78_RS13900	COG2072	flavoprotein involved in K transport
TK78_RS13930	COG1024	Enoyl-CoA hydratase
TK78_RS13965	COG1960	acyl-CoA dehydrogenase activity
TK78_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS13985	COG1960	acyl-CoA dehydrogenase activity
TK78_RS13990	COG1960	acyl-CoA dehydrogenase activity
TK78_RS14000	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS14010	COG1366	Belongs to the anti-sigma-factor antagonist family
TK78_RS14055	COG1131	(ABC) transporter
TK78_RS14065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TK78_RS14075	COG4821	SIS domain
TK78_RS14080	COG2205	protein histidine kinase activity
TK78_RS14085	COG0745	RESPONSE REGULATOR receiver
TK78_RS14100	COG1136	(ABC) transporter
TK78_RS14100	COG0577	efflux transmembrane transporter activity
TK78_RS14105	COG0577	efflux transmembrane transporter activity
TK78_RS14105	COG1136	(ABC) transporter
TK78_RS14115	COG0259	pyridoxamine-phosphate oxidase activity
TK78_RS14145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK78_RS14155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TK78_RS14200	COG1024	Enoyl-CoA hydratase
TK78_RS14205	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS14220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TK78_RS14235	COG2318	DinB family
TK78_RS14245	COG5006	permease, DMT superfamily
TK78_RS14250	COG0583	DNA-binding transcription factor activity
TK78_RS14255	COG0277	FAD linked oxidase domain protein
TK78_RS14255	COG0247	lactate metabolic process
TK78_RS14260	COG2205	protein histidine kinase activity
TK78_RS14290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TK78_RS14310	COG1335	isochorismatase
TK78_RS14405	COG1309	transcriptional regulator
TK78_RS14515	COG0583	DNA-binding transcription factor activity
TK78_RS14520	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS14525	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS14530	COG0515	serine threonine protein kinase
TK78_RS14540	COG2267	carboxylic ester hydrolase activity
TK78_RS14570	COG0671	phosphoesterase, PA-phosphatase related
TK78_RS14585	COG0667	Aldo Keto reductase
TK78_RS14615	COG2252	PERMEase
TK78_RS14625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TK78_RS14655	COG2814	Major facilitator Superfamily
TK78_RS14665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TK78_RS14670	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TK78_RS14675	COG1278	Cold shock
TK78_RS14690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS14695	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS14700	COG1120	ATPase activity
TK78_RS14705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK78_RS14745	COG1061	Type III restriction enzyme res subunit
TK78_RS14755	COG3973	AAA domain
TK78_RS14770	COG1984	allophanate hydrolase subunit 2
TK78_RS14780	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TK78_RS14815	COG1737	Transcriptional regulator
TK78_RS14820	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TK78_RS14825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TK78_RS14825	COG1263	PTS System
TK78_RS14845	COG4251	negative regulation of phosphorylation
TK78_RS14875	COG1175	transmembrane transport
TK78_RS14880	COG0395	ABC-type sugar transport system, permease component
TK78_RS14930	COG1846	Transcriptional regulator
TK78_RS14955	COG1595	DNA-templated transcription, initiation
TK78_RS14965	COG1132	(ABC) transporter
TK78_RS15010	COG0463	Glycosyl transferase, family 2
TK78_RS15015	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TK78_RS15025	COG0577	efflux transmembrane transporter activity
TK78_RS15030	COG0577	efflux transmembrane transporter activity
TK78_RS15030	COG1136	(ABC) transporter
TK78_RS15035	COG4585	Histidine kinase
TK78_RS15040	COG2197	response regulator
TK78_RS15045	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
TK78_RS15065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TK78_RS15070	COG1960	acyl-CoA dehydrogenase activity
TK78_RS15075	COG0019	diaminopimelate decarboxylase activity
TK78_RS15115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TK78_RS15130	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TK78_RS15140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TK78_RS15160	COG1132	(ABC) transporter
TK78_RS15170	COG3486	L-lysine 6-monooxygenase (NADPH) activity
TK78_RS15205	COG3293	Transposase
TK78_RS15230	COG2197	response regulator
TK78_RS15245	COG4585	Histidine kinase
TK78_RS15255	COG2197	response regulator
TK78_RS15260	COG4585	Histidine kinase
TK78_RS15280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TK78_RS15285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TK78_RS15290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TK78_RS15290	COG1754	DNA topoisomerase type I activity
TK78_RS15300	COG2890	protein-(glutamine-N5) methyltransferase activity
TK78_RS15310	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TK78_RS15315	COG2172	sigma factor antagonist activity
TK78_RS15320	COG1366	Belongs to the anti-sigma-factor antagonist family
TK78_RS15325	COG1111	helicase
TK78_RS15325	COG1205	dead DEAH box helicase
TK78_RS15385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TK78_RS15390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TK78_RS15400	COG2267	carboxylic ester hydrolase activity
TK78_RS15430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK78_RS15440	COG0251	oxidation-reduction process
TK78_RS15450	COG0003	Pfam Anion-transporting ATPase
TK78_RS15465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TK78_RS15470	COG1610	YqeY-like protein
TK78_RS15475	COG1408	metallophosphoesterase
TK78_RS15580	COG2226	methyltransferase
TK78_RS15585	COG0640	Transcriptional regulator
TK78_RS15590	COG0798	PFAM Bile acid sodium symporter
TK78_RS15620	COG3835	regulator
TK78_RS15630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TK78_RS15630	COG2080	2 iron, 2 sulfur cluster binding
TK78_RS15640	COG2755	lipolytic protein G-D-S-L family
TK78_RS15650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TK78_RS15670	COG1595	DNA-templated transcription, initiation
TK78_RS15695	COG0702	epimerase
TK78_RS15705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TK78_RS15710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TK78_RS15725	COG1802	Transcriptional regulator
TK78_RS15730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TK78_RS15735	COG0693	protein deglycase activity
TK78_RS15745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK78_RS15745	COG0515	serine threonine protein kinase
TK78_RS15755	COG0738	Major facilitator superfamily
TK78_RS15760	COG3226	Transcriptional regulator
TK78_RS15820	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TK78_RS15875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TK78_RS15880	COG0583	DNA-binding transcription factor activity
TK78_RS15890	COG0592	DNA-directed DNA polymerase activity
TK78_RS15920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TK78_RS15945	COG2197	response regulator
TK78_RS15950	COG4585	Histidine kinase
TK78_RS15955	COG0702	epimerase
TK78_RS15965	COG3844	kynureninase activity
TK78_RS15980	COG0477	Major facilitator Superfamily
TK78_RS15985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TK78_RS15990	COG0191	fructose-bisphosphate aldolase activity
TK78_RS15995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TK78_RS16010	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TK78_RS16045	COG0542	response to heat
TK78_RS16080	COG0789	Transcriptional regulator
TK78_RS16085	COG0484	heat shock protein binding
TK78_RS16090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TK78_RS16095	COG0443	Heat shock 70 kDa protein
TK78_RS16100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TK78_RS16105	COG2181	nitrate reductase activity
TK78_RS16105	COG0247	lactate metabolic process
TK78_RS16125	COG0717	Belongs to the dCTP deaminase family
TK78_RS16285	COG2205	protein histidine kinase activity
TK78_RS16290	COG0745	RESPONSE REGULATOR receiver
TK78_RS16320	COG2124	cytochrome p450
TK78_RS16325	COG2124	cytochrome p450
TK78_RS16330	COG1024	Enoyl-CoA hydratase
TK78_RS16350	COG3585	molybdate ion transport
TK78_RS16375	COG0531	amino acid
TK78_RS16385	COG0475	glutathione-regulated potassium exporter activity
TK78_RS16390	COG2409	Drug exporters of the RND superfamily
TK78_RS16395	COG3594	Acyltransferase
TK78_RS16405	COG0513	Belongs to the DEAD box helicase family
TK78_RS16410	COG1278	Cold shock
TK78_RS16470	COG2268	Band 7 protein
TK78_RS16495	COG4941	Belongs to the sigma-70 factor family
TK78_RS16520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TK78_RS16545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TK78_RS16585	COG1191	sigma factor activity
TK78_RS16590	COG1191	sigma factor activity
TK78_RS16605	COG1846	Transcriptional regulator
TK78_RS16615	COG2353	YceI-like domain
TK78_RS16620	COG3467	pyridoxamine 5'-phosphate
TK78_RS16635	COG0477	Major facilitator Superfamily
TK78_RS16650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TK78_RS16660	COG2205	protein histidine kinase activity
TK78_RS16665	COG0745	RESPONSE REGULATOR receiver
TK78_RS16685	COG1595	DNA-templated transcription, initiation
TK78_RS16690	COG1252	NADH dehydrogenase
TK78_RS16695	COG3629	intracellular signal transduction
TK78_RS16695	COG3903	Transcriptional regulator
TK78_RS16760	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS16765	COG1595	DNA-templated transcription, initiation
TK78_RS16790	COG1960	acyl-CoA dehydrogenase activity
TK78_RS16805	COG3693	PFAM glycoside hydrolase, family 10
TK78_RS16855	COG1725	Transcriptional regulator
TK78_RS16920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK78_RS16935	COG0653	protein targeting
TK78_RS16955	COG0006	proline dipeptidase activity
TK78_RS16975	COG1999	signal sequence binding
TK78_RS16985	COG2372	response to copper ion
TK78_RS16990	COG2837	iron assimilation
TK78_RS17000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TK78_RS17005	COG0561	phosphatase activity
TK78_RS17030	COG1131	(ABC) transporter
TK78_RS17045	COG0789	Transcriptional regulator
TK78_RS17050	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
TK78_RS17060	COG0561	phosphatase activity
TK78_RS17070	COG4988	ABC transporter
TK78_RS17075	COG1294	oxidase, subunit
TK78_RS17080	COG1271	oxidase subunit
TK78_RS17085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK78_RS17090	COG1609	Transcriptional regulator
TK78_RS17095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TK78_RS17105	COG3152	Membrane
TK78_RS17110	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TK78_RS17135	COG0662	Cupin 2, conserved barrel domain protein
TK78_RS17140	COG1950	PFAM Membrane protein of
TK78_RS17145	COG0626	cystathionine gamma-synthase activity
TK78_RS17165	COG2814	Major facilitator Superfamily
TK78_RS17195	COG0596	Alpha beta hydrolase
TK78_RS17200	COG1309	transcriptional regulator
TK78_RS17205	COG0305	Participates in initiation and elongation during chromosome replication
TK78_RS17215	COG0359	binds to the 23S rRNA
TK78_RS17220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TK78_RS17225	COG0629	single-stranded DNA binding
TK78_RS17230	COG0360	Binds together with S18 to 16S ribosomal RNA
TK78_RS17255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TK78_RS17280	COG0617	tRNA 3'-terminal CCA addition
TK78_RS17295	COG0515	serine threonine protein kinase
TK78_RS17295	COG2815	serine threonine protein kinase
TK78_RS17300	COG1595	DNA-templated transcription, initiation
TK78_RS17310	COG0492	ferredoxin-NADP+ reductase activity
TK78_RS17315	COG3118	belongs to the thioredoxin family
TK78_RS17330	COG1192	Involved in chromosome partitioning
TK78_RS17335	COG0357	Ribosomal RNA small subunit methyltransferase G
TK78_RS17345	COG0706	membrane insertase activity
TK78_RS17350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TK78_RS17355	COG0594	ribonuclease P activity
TK78_RS17360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TK78_RS17375	COG0592	DNA-directed DNA polymerase activity
TK78_RS17380	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TK78_RS17385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TK78_RS17390	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TK78_RS17400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TK78_RS17440	COG0515	serine threonine protein kinase
TK78_RS17470	COG0705	Rhomboid family
TK78_RS17485	COG3764	Sortase (surface protein transpeptidase)
TK78_RS17500	COG3764	Sortase (surface protein transpeptidase)
TK78_RS17505	COG3764	Sortase (surface protein transpeptidase)
TK78_RS17510	COG0515	serine threonine protein kinase
TK78_RS17515	COG0768	penicillin binding
TK78_RS17530	COG1716	ATPase activity
TK78_RS17535	COG1716	ATPase activity
TK78_RS17550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TK78_RS17555	COG1733	regulation of RNA biosynthetic process
TK78_RS17580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TK78_RS17585	COG2151	metal-sulfur cluster biosynthetic enzyme
TK78_RS17590	COG3396	Phenylacetate-CoA oxygenase
TK78_RS17595	COG3460	Phenylacetate-CoA oxygenase
TK78_RS17600	COG3396	Phenylacetate-CoA oxygenase
TK78_RS17625	COG1309	transcriptional regulator
TK78_RS17630	COG1522	sequence-specific DNA binding
TK78_RS17665	COG0604	alcohol dehydrogenase
TK78_RS17680	COG1136	(ABC) transporter
TK78_RS17680	COG4591	ABC-type transport system involved in lipoprotein release permease component
TK78_RS17695	COG0515	serine threonine protein kinase
TK78_RS17700	COG0515	serine threonine protein kinase
TK78_RS17725	COG0022	dehydrogenase e1 component
TK78_RS17730	COG0508	dehydrogenase complex catalyzes the overall conversion of
TK78_RS17750	COG1802	Transcriptional regulator
TK78_RS17755	COG2271	Major facilitator Superfamily
TK78_RS17765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK78_RS17795	COG1362	aminopeptidase activity
TK78_RS17800	COG1960	acyl-CoA dehydrogenase activity
TK78_RS17810	COG1741	Belongs to the pirin family
TK78_RS17825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TK78_RS17835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK78_RS17840	COG0745	RESPONSE REGULATOR receiver
TK78_RS17845	COG2205	protein histidine kinase activity
TK78_RS17850	COG2304	oxidoreductase activity
TK78_RS17880	COG0431	NADPH-dependent FMN reductase
TK78_RS17900	COG1672	PFAM Archaeal ATPase
TK78_RS17900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TK78_RS17915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS17920	COG0180	Tryptophanyl-tRNA synthetase
TK78_RS17930	COG2255	four-way junction helicase activity
TK78_RS17955	COG0475	glutathione-regulated potassium exporter activity
TK78_RS17960	COG0490	domain, Protein
TK78_RS17985	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TK78_RS18005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TK78_RS18025	COG3903	Transcriptional regulator
TK78_RS18025	COG3629	intracellular signal transduction
TK78_RS18045	COG1045	serine acetyltransferase
TK78_RS18070	COG0367	asparagine synthase
TK78_RS18080	COG1960	acyl-CoA dehydrogenase activity
TK78_RS18115	COG3903	Transcriptional regulator
TK78_RS18115	COG3629	intracellular signal transduction
TK78_RS18135	COG0305	Participates in initiation and elongation during chromosome replication
TK78_RS18175	COG0151	Belongs to the GarS family
TK78_RS18190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TK78_RS18200	COG2197	response regulator
TK78_RS18235	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TK78_RS18240	COG0047	phosphoribosylformylglycinamidine synthase activity
TK78_RS18245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TK78_RS18255	COG0741	lytic transglycosylase activity
TK78_RS18255	COG0739	heme binding
TK78_RS18255	COG1196	nuclear chromosome segregation
TK78_RS18275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TK78_RS18310	COG1643	Atp-dependent helicase
TK78_RS18320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TK78_RS18320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TK78_RS18325	COG0785	Cytochrome C biogenesis protein
TK78_RS18355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TK78_RS18360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TK78_RS18370	COG0513	Belongs to the DEAD box helicase family
TK78_RS18395	COG2079	MmgE PrpD family protein
TK78_RS18400	COG3800	Transcriptional regulator
TK78_RS18400	COG1396	sequence-specific DNA binding
TK78_RS18405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TK78_RS18420	COG0789	Transcriptional regulator
TK78_RS18430	COG0741	lytic transglycosylase activity
TK78_RS18430	COG0739	heme binding
TK78_RS18430	COG1196	nuclear chromosome segregation
TK78_RS18435	COG0667	Aldo Keto reductase
TK78_RS18445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TK78_RS18450	COG0579	oxidoreductase
TK78_RS18475	COG1252	NADH dehydrogenase
TK78_RS18490	COG1846	Transcriptional regulator
TK78_RS18515	COG2197	response regulator
TK78_RS18520	COG4585	Histidine kinase
TK78_RS18530	COG1131	(ABC) transporter
TK78_RS18600	COG1196	nuclear chromosome segregation
TK78_RS18600	COG0739	heme binding
TK78_RS18600	COG0741	lytic transglycosylase activity
TK78_RS18605	COG0671	phosphoesterase, PA-phosphatase related
TK78_RS18625	COG1937	Protein conserved in bacteria
TK78_RS18635	COG0306	phosphate transporter
TK78_RS18655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TK78_RS18660	COG0494	nUDIX hydrolase
TK78_RS18660	COG0406	alpha-ribazole phosphatase activity
TK78_RS18685	COG1725	Transcriptional regulator
TK78_RS18695	COG0456	acetyltransferase
TK78_RS18700	COG0737	Belongs to the 5'-nucleotidase family
TK78_RS18730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TK78_RS18750	COG1335	isochorismatase
TK78_RS18780	COG0739	heme binding
TK78_RS18810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK78_RS18815	COG1609	Transcriptional regulator
TK78_RS18820	COG0745	RESPONSE REGULATOR receiver
TK78_RS18850	COG2897	thiosulfate sulfurtransferase activity
TK78_RS18880	COG3485	protocatechuate 3,4-dioxygenase
TK78_RS18895	COG1490	D-aminoacyl-tRNA deacylase activity
TK78_RS18910	COG4552	Acetyltransferase involved in intracellular survival and related
TK78_RS18975	COG0438	transferase activity, transferring glycosyl groups
TK78_RS19040	COG0588	phosphoglycerate mutase activity
TK78_RS19055	COG5002	protein histidine kinase activity
TK78_RS19075	COG1329	Transcriptional regulator
TK78_RS19080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TK78_RS19085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TK78_RS19110	COG3467	pyridoxamine 5'-phosphate
TK78_RS19115	COG0215	cysteine-tRNA ligase activity
TK78_RS19130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TK78_RS19140	COG3842	ATPase activity
TK78_RS19175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TK78_RS19220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TK78_RS19230	COG0165	Argininosuccinate lyase
TK78_RS19245	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TK78_RS19250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS19265	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
TK78_RS19265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS19290	COG2815	serine threonine protein kinase
TK78_RS19290	COG0515	serine threonine protein kinase
TK78_RS19345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TK78_RS19355	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TK78_RS19375	COG1131	(ABC) transporter
TK78_RS19395	COG4585	Histidine kinase
TK78_RS19405	COG0666	response to abiotic stimulus
TK78_RS19430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TK78_RS19455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TK78_RS19535	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS19580	COG0076	glutamate decarboxylase activity
TK78_RS19585	COG0655	NAD(P)H dehydrogenase (quinone) activity
TK78_RS19595	COG0393	Putative heavy-metal-binding
TK78_RS19600	COG0586	Pfam SNARE associated Golgi protein
TK78_RS19610	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TK78_RS19615	COG2027	D-alanyl-D-alanine carboxypeptidase
TK78_RS19625	COG0037	tRNA processing
TK78_RS19640	COG0302	gtp cyclohydrolase
TK78_RS19655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TK78_RS19660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TK78_RS19675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TK78_RS19675	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TK78_RS19685	COG0517	IMP dehydrogenase activity
TK78_RS19685	COG1125	glycine betaine transport
TK78_RS19690	COG1174	glycine betaine transport
TK78_RS19695	COG1174	glycine betaine transport
TK78_RS19700	COG1732	Glycine betaine
TK78_RS19710	COG0649	NAD binding
TK78_RS19725	COG2197	response regulator
TK78_RS19750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TK78_RS19755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TK78_RS19765	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TK78_RS19785	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TK78_RS19820	COG0739	heme binding
TK78_RS19825	COG2205	protein histidine kinase activity
TK78_RS19830	COG0745	RESPONSE REGULATOR receiver
TK78_RS19840	COG1595	DNA-templated transcription, initiation
TK78_RS19845	COG1194	a g-specific adenine glycosylase
TK78_RS19855	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TK78_RS19875	COG0248	Ppx GppA phosphatase
TK78_RS19880	COG1082	Xylose isomerase domain protein TIM barrel
TK78_RS19890	COG0129	dihydroxy-acid dehydratase activity
TK78_RS19900	COG4991	sh3 domain protein
TK78_RS19910	COG0842	Transport permease protein
TK78_RS19910	COG1129	ABC transporter
TK78_RS19920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TK78_RS19945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TK78_RS19950	COG2223	nitrite transmembrane transporter activity
TK78_RS19955	COG0123	including yeast histone deacetylase and acetoin utilization protein
TK78_RS20005	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TK78_RS20010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TK78_RS20015	COG0181	hydroxymethylbilane synthase activity
TK78_RS20020	COG1648	precorrin-2 dehydrogenase activity
TK78_RS20020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TK78_RS20025	COG0113	porphobilinogen synthase activity
TK78_RS20060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TK78_RS20090	COG0789	Transcriptional regulator
TK78_RS20095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TK78_RS20110	COG0018	arginyl-trna synthetase
TK78_RS20115	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TK78_RS20135	COG1690	Belongs to the RtcB family
TK78_RS20140	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TK78_RS20150	COG2188	Transcriptional regulator
TK78_RS20170	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TK78_RS20185	COG1116	anion transmembrane transporter activity
TK78_RS20215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TK78_RS20220	COG0406	alpha-ribazole phosphatase activity
TK78_RS20225	COG2382	esterase
TK78_RS20240	COG0785	Cytochrome C biogenesis protein
TK78_RS20245	COG1333	cytochrome c biogenesis protein
TK78_RS20250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TK78_RS20260	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TK78_RS20275	COG0163	prenyltransferase activity
TK78_RS20285	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TK78_RS20315	COG1309	transcriptional regulator
TK78_RS20335	COG2208	phosphoserine phosphatase activity
TK78_RS20335	COG2770	Histidine kinase
TK78_RS20350	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS20405	COG3940	Belongs to the glycosyl hydrolase 43 family
TK78_RS20415	COG0456	acetyltransferase
TK78_RS20435	COG0667	Aldo Keto reductase
TK78_RS20510	COG0768	penicillin binding
TK78_RS20525	COG3386	PFAM SMP-30 Gluconolaconase
TK78_RS20540	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TK78_RS20565	COG0667	Aldo Keto reductase
TK78_RS20655	COG1686	Belongs to the peptidase S11 family
TK78_RS20725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TK78_RS20760	COG2814	Major facilitator Superfamily
TK78_RS20765	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS20785	COG1846	Transcriptional regulator
TK78_RS20790	COG3384	dioxygenase
TK78_RS20810	COG0477	Major facilitator Superfamily
TK78_RS20830	COG0243	molybdopterin cofactor binding
TK78_RS20835	COG0437	4 iron, 4 sulfur cluster binding
TK78_RS20855	COG1970	mechanosensitive ion channel activity
TK78_RS20865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TK78_RS20880	COG3263	regulation of cellular component size
TK78_RS20890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TK78_RS20895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TK78_RS20905	COG0315	cyclic pyranopterin monophosphate synthase activity
TK78_RS20910	COG0521	Mo-molybdopterin cofactor biosynthetic process
TK78_RS20915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TK78_RS20940	COG1834	amidinotransferase
TK78_RS20945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TK78_RS20950	COG1073	alpha beta
TK78_RS20990	COG0708	Exodeoxyribonuclease III
TK78_RS21000	COG2072	flavoprotein involved in K transport
TK78_RS21010	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS21025	COG0793	Belongs to the peptidase S41A family
TK78_RS21025	COG4946	Tricorn protease homolog
TK78_RS21035	COG2409	Drug exporters of the RND superfamily
TK78_RS21045	COG0310	cobalt ion transport
TK78_RS21055	COG1122	ATPase activity
TK78_RS21060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TK78_RS21085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TK78_RS21090	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
TK78_RS21100	COG1115	amino acid carrier protein
TK78_RS21110	COG0442	prolyl-tRNA aminoacylation
TK78_RS21115	COG2207	Transcriptional regulator
TK78_RS21120	COG2223	nitrite transmembrane transporter activity
TK78_RS21135	COG2197	response regulator
TK78_RS21165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TK78_RS21190	COG0084	hydrolase, TatD family'
TK78_RS21200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TK78_RS21205	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TK78_RS21220	COG4115	mRNA cleavage
TK78_RS21235	COG4585	Histidine kinase
TK78_RS21240	COG2197	response regulator
TK78_RS21245	COG0488	(ABC) transporter
TK78_RS21275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK78_RS21290	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TK78_RS21300	COG2197	response regulator
TK78_RS21305	COG1846	Transcriptional regulator
TK78_RS21310	COG4106	trans-aconitate 2-methyltransferase activity
TK78_RS21340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TK78_RS21350	COG0193	aminoacyl-tRNA hydrolase activity
TK78_RS21355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TK78_RS21360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TK78_RS21365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TK78_RS21375	COG4585	Histidine kinase
TK78_RS21405	COG2124	cytochrome p450
TK78_RS21410	COG2124	cytochrome p450
TK78_RS21450	COG0346	lactoylglutathione lyase activity
TK78_RS21455	COG0640	Transcriptional regulator
TK78_RS21460	COG2814	Major facilitator Superfamily
TK78_RS21465	COG1136	(ABC) transporter
TK78_RS21470	COG0577	efflux transmembrane transporter activity
TK78_RS21520	COG1335	isochorismatase
TK78_RS21540	COG0515	serine threonine protein kinase
TK78_RS21540	COG2815	serine threonine protein kinase
TK78_RS21565	COG1652	LysM domain
TK78_RS21575	COG0148	phosphopyruvate hydratase activity
TK78_RS21595	COG1252	NADH dehydrogenase
TK78_RS21600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TK78_RS21605	COG0577	efflux transmembrane transporter activity
TK78_RS21605	COG1136	(ABC) transporter
TK78_RS21610	COG1136	(ABC) transporter
TK78_RS21635	COG0183	Belongs to the thiolase family
TK78_RS21640	COG2755	lipolytic protein G-D-S-L family
TK78_RS21665	COG3409	Peptidoglycan-binding domain 1 protein
TK78_RS21670	COG1136	(ABC) transporter
TK78_RS21670	COG0577	efflux transmembrane transporter activity
TK78_RS21675	COG0577	efflux transmembrane transporter activity
TK78_RS21675	COG1136	(ABC) transporter
TK78_RS21720	COG0531	amino acid
TK78_RS21725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TK78_RS21740	COG1228	amidohydrolase
TK78_RS21750	COG1191	sigma factor activity
TK78_RS21755	COG1366	Belongs to the anti-sigma-factor antagonist family
TK78_RS21785	COG3104	oligopeptide transport
TK78_RS21790	COG0745	RESPONSE REGULATOR receiver
TK78_RS21795	COG2205	protein histidine kinase activity
TK78_RS21830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TK78_RS21865	COG2226	methyltransferase
TK78_RS21900	COG1316	TRANSCRIPTIONal
TK78_RS21910	COG1316	TRANSCRIPTIONal
TK78_RS21920	COG1316	TRANSCRIPTIONal
TK78_RS21925	COG1316	TRANSCRIPTIONal
TK78_RS21930	COG1316	TRANSCRIPTIONal
TK78_RS21945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TK78_RS21955	COG0778	Nitroreductase
TK78_RS21955	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TK78_RS21960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TK78_RS21995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK78_RS22000	COG2835	tetraacyldisaccharide 4'-kinase activity
TK78_RS22010	COG1482	cell wall glycoprotein biosynthetic process
TK78_RS22020	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TK78_RS22060	COG0714	Associated with various cellular activities
TK78_RS22080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK78_RS22085	COG0745	RESPONSE REGULATOR receiver
TK78_RS22090	COG5000	phosphorelay sensor kinase activity
TK78_RS22090	COG5002	protein histidine kinase activity
TK78_RS22095	COG0823	Involved in the tonB-independent uptake of proteins
TK78_RS22100	COG1040	competence protein
TK78_RS22105	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TK78_RS22110	COG2197	response regulator
TK78_RS22115	COG3214	Protein conserved in bacteria
TK78_RS22125	COG0653	protein targeting
TK78_RS22150	COG2902	Dehydrogenase
TK78_RS22155	COG1134	teichoic acid transport
TK78_RS22175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TK78_RS22180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TK78_RS22185	COG1073	alpha beta
TK78_RS22185	COG2226	methyltransferase
TK78_RS22195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TK78_RS22200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TK78_RS22205	COG0438	transferase activity, transferring glycosyl groups
TK78_RS22210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TK78_RS22215	COG0395	ABC-type sugar transport system, permease component
TK78_RS22220	COG1175	transmembrane transport
TK78_RS22225	COG1653	transport
TK78_RS22235	COG0515	serine threonine protein kinase
TK78_RS22240	COG0515	serine threonine protein kinase
TK78_RS22245	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TK78_RS22260	COG2884	Cell division ATP-binding protein ftsE
TK78_RS22265	COG2177	Part of the ABC transporter FtsEX involved in
TK78_RS22270	COG0793	Belongs to the peptidase S41A family
TK78_RS22275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TK78_RS22295	COG0583	DNA-binding transcription factor activity
TK78_RS22315	COG2223	nitrite transmembrane transporter activity
TK78_RS22345	COG3973	AAA domain
TK78_RS22345	COG3973	AAA domain
TK78_RS22355	COG0776	regulation of translation
TK78_RS22370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TK78_RS22375	COG1678	Uncharacterized ACR, COG1678
TK78_RS22395	COG0395	ABC-type sugar transport system, permease component
TK78_RS22400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TK78_RS22460	COG2814	Major facilitator Superfamily
TK78_RS22470	COG3654	unkown
TK78_RS22485	COG3480	Lon protease (S16) C-terminal proteolytic domain
TK78_RS22505	COG1732	Glycine betaine
TK78_RS22510	COG1174	glycine betaine transport
TK78_RS22515	COG1125	glycine betaine transport
TK78_RS22515	COG0517	IMP dehydrogenase activity
TK78_RS22520	COG1174	glycine betaine transport
TK78_RS22530	COG3185	4-Hydroxyphenylpyruvate dioxygenase
TK78_RS22540	COG0277	FAD linked oxidase domain protein
TK78_RS22575	COG1335	isochorismatase
TK78_RS22585	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TK78_RS22595	COG1113	amino acid transport
TK78_RS22610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS22645	COG1263	PTS System
TK78_RS22650	COG1263	PTS System
TK78_RS22655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TK78_RS22660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TK78_RS22670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TK78_RS22690	COG0477	Major facilitator Superfamily
TK78_RS22715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TK78_RS22730	COG4555	ABC transporter
TK78_RS22745	COG2733	membrane
TK78_RS22895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TK78_RS22905	COG3764	Sortase (surface protein transpeptidase)
TK78_RS22915	COG0706	membrane insertase activity
TK78_RS22915	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
TK78_RS22925	COG4702	Belongs to the UPF0303 family
TK78_RS22930	COG0673	inositol 2-dehydrogenase activity
TK78_RS22935	COG1940	carbohydrate kinase activity
TK78_RS22950	COG1309	transcriptional regulator
TK78_RS22960	COG2188	Transcriptional regulator
TK78_RS22965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TK78_RS23045	COG3397	chitin binding
TK78_RS23050	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS23070	COG1126	abc transporter atp-binding protein
TK78_RS23075	COG0765	amino acid transport
TK78_RS23080	COG0765	amino acid transport
TK78_RS23085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TK78_RS23105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS23195	COG2985	domain, Protein
TK78_RS23210	COG0395	ABC-type sugar transport system, permease component
TK78_RS23225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TK78_RS23230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TK78_RS23235	COG1595	DNA-templated transcription, initiation
TK78_RS23245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK78_RS23250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TK78_RS23275	COG3629	intracellular signal transduction
TK78_RS23275	COG3903	Transcriptional regulator
TK78_RS23280	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS23285	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS23345	COG0519	Catalyzes the synthesis of GMP from XMP
TK78_RS23365	COG4977	sequence-specific DNA binding
TK78_RS23370	COG0589	response to stress
TK78_RS23375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TK78_RS23400	COG3486	L-lysine 6-monooxygenase (NADPH) activity
TK78_RS23405	COG0076	glutamate decarboxylase activity
TK78_RS23410	COG2375	cellular response to nickel ion
TK78_RS23425	COG1733	regulation of RNA biosynthetic process
TK78_RS23435	COG3537	Alpha-1,2-mannosidase
TK78_RS23445	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TK78_RS23455	COG1960	acyl-CoA dehydrogenase activity
TK78_RS23470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TK78_RS23475	COG1309	transcriptional regulator
TK78_RS23485	COG2311	Membrane
TK78_RS23520	COG1946	Acyl-CoA thioesterase
TK78_RS23525	COG1960	acyl-CoA dehydrogenase activity
TK78_RS23545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TK78_RS23580	COG2815	serine threonine protein kinase
TK78_RS23580	COG0515	serine threonine protein kinase
TK78_RS23590	COG0657	acetylesterase activity
TK78_RS23660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK78_RS23670	COG0028	Belongs to the TPP enzyme family
TK78_RS23705	COG1472	Belongs to the glycosyl hydrolase 3 family
TK78_RS23710	COG0583	DNA-binding transcription factor activity
TK78_RS23730	COG1404	Belongs to the peptidase S8 family
TK78_RS23735	COG1672	PFAM Archaeal ATPase
TK78_RS23735	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TK78_RS23760	COG0515	serine threonine protein kinase
TK78_RS23785	COG1609	Transcriptional regulator
TK78_RS23790	COG0673	inositol 2-dehydrogenase activity
TK78_RS23805	COG2318	DinB family
TK78_RS23845	COG0596	Alpha beta hydrolase
TK78_RS23865	COG2197	response regulator
TK78_RS23870	COG0477	Major facilitator Superfamily
TK78_RS23880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TK78_RS23905	COG2409	Drug exporters of the RND superfamily
TK78_RS23920	COG2318	DinB family
TK78_RS23930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK78_RS23940	COG3718	enzyme involved in inositol metabolism
TK78_RS23945	COG3962	Belongs to the TPP enzyme family
TK78_RS23960	COG4585	Histidine kinase
TK78_RS23970	COG0671	phosphoesterase, PA-phosphatase related
TK78_RS23980	COG1131	(ABC) transporter
TK78_RS24015	COG4585	Histidine kinase
TK78_RS24020	COG2197	response regulator
TK78_RS24050	COG0629	single-stranded DNA binding
TK78_RS24075	COG1136	(ABC) transporter
TK78_RS24075	COG0577	efflux transmembrane transporter activity
TK78_RS24090	COG2346	COG2346, Truncated hemoglobins
TK78_RS24095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TK78_RS24115	COG0515	serine threonine protein kinase
TK78_RS24125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TK78_RS24140	COG1486	melibiose metabolic process
TK78_RS24145	COG0395	ABC-type sugar transport system, permease component
TK78_RS24150	COG1175	transmembrane transport
TK78_RS24160	COG1940	carbohydrate kinase activity
TK78_RS24165	COG0668	transmembrane transport
TK78_RS24175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TK78_RS24175	COG3291	Pkd domain containing protein
TK78_RS24200	COG4266	Belongs to the allantoicase family
TK78_RS24240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TK78_RS24255	COG2252	PERMEase
TK78_RS24270	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS24285	COG2755	lipolytic protein G-D-S-L family
TK78_RS24290	COG0110	maltose O-acetyltransferase activity
TK78_RS24305	COG0640	Transcriptional regulator
TK78_RS24310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TK78_RS24320	COG0783	Belongs to the Dps family
TK78_RS24325	COG0584	glycerophosphoryl diester phosphodiesterase
TK78_RS24330	COG1113	amino acid transport
TK78_RS24335	COG1113	amino acid transport
TK78_RS24340	COG1268	BioY protein
TK78_RS24350	COG1113	amino acid transport
TK78_RS24370	COG0475	glutathione-regulated potassium exporter activity
TK78_RS24380	COG3594	Acyltransferase
TK78_RS24400	COG0544	peptidyl-prolyl cis-trans isomerase activity
TK78_RS24405	COG0740	serine-type endopeptidase activity
TK78_RS24410	COG0740	serine-type endopeptidase activity
TK78_RS24415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TK78_RS24425	COG0525	valine-tRNA ligase activity
TK78_RS24430	COG0285	dihydrofolate synthase activity
TK78_RS24440	COG0105	UTP biosynthetic process
TK78_RS24445	COG1077	Cell shape determining protein MreB Mrl
TK78_RS24460	COG0768	penicillin binding
TK78_RS24465	COG0772	Belongs to the SEDS family
TK78_RS24490	COG1530	ribonuclease E activity
TK78_RS24495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TK78_RS24500	COG0673	inositol 2-dehydrogenase activity
TK78_RS24525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TK78_RS24530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TK78_RS24535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TK78_RS24555	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TK78_RS24560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TK78_RS24570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TK78_RS24585	COG0501	Belongs to the peptidase M48B family
TK78_RS24590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TK78_RS24600	COG0799	negative regulation of ribosome biogenesis
TK78_RS24605	COG0588	phosphoglycerate mutase activity
TK78_RS24640	COG0495	leucyl-tRNA aminoacylation
TK78_RS24650	COG1307	EDD domain protein, DegV family
TK78_RS24655	COG1555	photosystem II stabilization
TK78_RS24660	COG1234	tRNA 3'-trailer cleavage
TK78_RS24685	COG0268	Binds directly to 16S ribosomal RNA
TK78_RS24690	COG0481	GTPase activity
TK78_RS24695	COG1022	Amp-dependent synthetase and ligase
TK78_RS24725	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS24765	COG1420	regulation of RNA biosynthetic process
TK78_RS24770	COG0484	heat shock protein binding
TK78_RS24785	COG0537	adenosine 5'-monophosphoramidase activity
TK78_RS24790	COG1234	tRNA 3'-trailer cleavage
TK78_RS24795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TK78_RS24805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK78_RS24815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TK78_RS24825	COG2315	Protein conserved in bacteria
TK78_RS24845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TK78_RS24860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TK78_RS24880	COG1381	Involved in DNA repair and RecF pathway recombination
TK78_RS24885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TK78_RS24895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TK78_RS24900	COG1121	(ABC) transporter
TK78_RS24910	COG0423	glycine-tRNA ligase activity
TK78_RS25065	COG3848	Pyruvate phosphate dikinase
TK78_RS25065	COG0574	Belongs to the PEP-utilizing enzyme family
TK78_RS25080	COG2066	Belongs to the glutaminase family
TK78_RS25085	COG0604	alcohol dehydrogenase
TK78_RS25090	COG1309	transcriptional regulator
TK78_RS25095	COG0477	Major facilitator Superfamily
TK78_RS25125	COG2188	Transcriptional regulator
TK78_RS25145	COG3842	ATPase activity
TK78_RS25155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TK78_RS25155	COG0574	Belongs to the PEP-utilizing enzyme family
TK78_RS25175	COG2146	nitrite reductase [NAD(P)H] activity
TK78_RS25175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TK78_RS25180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TK78_RS25180	COG2146	nitrite reductase [NAD(P)H] activity
TK78_RS25225	COG2949	membrane
TK78_RS25235	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TK78_RS25245	COG0358	DNA primase activity
TK78_RS25250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TK78_RS25265	COG1070	Carbohydrate kinase
TK78_RS25310	COG1857	crispr-associated protein
TK78_RS25325	COG1518	maintenance of DNA repeat elements
TK78_RS25345	COG0477	Major facilitator Superfamily
TK78_RS25350	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS25355	COG1309	transcriptional regulator
TK78_RS25360	COG0825	malonyl-CoA metabolic process
TK78_RS25360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TK78_RS25365	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS25370	COG3291	Pkd domain containing protein
TK78_RS25385	COG1522	sequence-specific DNA binding
TK78_RS25415	COG2130	NADP-dependent
TK78_RS25420	COG1764	response to oxidative stress
TK78_RS25430	COG1280	lysine exporter protein (LysE YggA)
TK78_RS25450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TK78_RS25455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TK78_RS25460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TK78_RS25475	COG1741	Belongs to the pirin family
TK78_RS25495	COG1929	Belongs to the glycerate kinase type-1 family
TK78_RS25505	COG0745	RESPONSE REGULATOR receiver
TK78_RS25510	COG2205	protein histidine kinase activity
TK78_RS25520	COG0789	Transcriptional regulator
TK78_RS25525	COG0667	Aldo Keto reductase
TK78_RS25545	COG3409	Peptidoglycan-binding domain 1 protein
TK78_RS25560	COG2197	response regulator
TK78_RS25565	COG4585	Histidine kinase
TK78_RS25580	COG1309	transcriptional regulator
TK78_RS25585	COG0477	Major facilitator Superfamily
TK78_RS25595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TK78_RS25640	COG1358	cellular component organization or biogenesis
TK78_RS25685	COG0483	inositol monophosphate 1-phosphatase activity
TK78_RS25725	COG2259	Doxx family
TK78_RS25775	COG2124	cytochrome p450
TK78_RS25780	COG0183	Belongs to the thiolase family
TK78_RS25790	COG3845	ABC transporter
TK78_RS25885	COG1309	transcriptional regulator
TK78_RS25890	COG0438	transferase activity, transferring glycosyl groups
TK78_RS25920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS25945	COG1960	acyl-CoA dehydrogenase activity
TK78_RS25950	COG0183	Belongs to the thiolase family
TK78_RS25960	COG2030	dehydratase
TK78_RS25970	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS25980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK78_RS25985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TK78_RS26005	COG0800	Aldolase
TK78_RS26010	COG3022	response to hydroperoxide
TK78_RS26040	COG2273	Hydrolase Family 16
TK78_RS26075	COG0384	phenazine biosynthesis protein PhzF
TK78_RS26085	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS26090	COG3540	Alkaline phosphatase
TK78_RS26100	COG2814	Major facilitator Superfamily
TK78_RS26115	COG1834	amidinotransferase
TK78_RS26135	COG1120	ATPase activity
TK78_RS26140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS26205	COG1994	Peptidase M50
TK78_RS26225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TK78_RS26230	COG0477	Major facilitator Superfamily
TK78_RS26245	COG2814	Major facilitator Superfamily
TK78_RS26250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TK78_RS26250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK78_RS26255	COG2132	Multicopper oxidase
TK78_RS26280	COG0174	glutamine synthetase
TK78_RS26325	COG2814	Major facilitator Superfamily
TK78_RS26330	COG2890	protein-(glutamine-N5) methyltransferase activity
TK78_RS26340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TK78_RS26355	COG1609	Transcriptional regulator
TK78_RS26360	COG2182	Extracellular solute-binding protein
TK78_RS26370	COG0395	ABC-type sugar transport system, permease component
TK78_RS26375	COG0366	Alpha amylase catalytic
TK78_RS26445	COG2197	response regulator
TK78_RS26450	COG4585	Histidine kinase
TK78_RS26455	COG0745	RESPONSE REGULATOR receiver
TK78_RS26480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TK78_RS26485	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TK78_RS26510	COG2362	D-Aminopeptidase
TK78_RS26515	COG1846	Transcriptional regulator
TK78_RS26525	COG3896	Chloramphenicol phosphotransferase-like protein
TK78_RS26530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TK78_RS26575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TK78_RS26580	COG0321	lipoyl(octanoyl) transferase activity
TK78_RS26600	COG1090	epimerase
TK78_RS26620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TK78_RS26630	COG0508	dehydrogenase complex catalyzes the overall conversion of
TK78_RS26635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TK78_RS26640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TK78_RS26645	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TK78_RS26660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TK78_RS26680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK78_RS26685	COG4106	trans-aconitate 2-methyltransferase activity
TK78_RS26705	COG4585	Histidine kinase
TK78_RS26710	COG2197	response regulator
TK78_RS26715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TK78_RS26725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TK78_RS26745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK78_RS26750	COG1104	cysteine desulfurase activity
TK78_RS26755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TK78_RS26760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TK78_RS26770	COG1376	ErfK ybiS ycfS ynhG family protein
TK78_RS26780	COG1845	cytochrome c oxidase, subunit III
TK78_RS26785	COG2010	Cytochrome c
TK78_RS26790	COG0723	plastoquinol--plastocyanin reductase activity
TK78_RS26795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TK78_RS26800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TK78_RS26805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TK78_RS26850	COG0438	transferase activity, transferring glycosyl groups
TK78_RS26870	COG0003	Pfam Anion-transporting ATPase
TK78_RS26880	COG1940	carbohydrate kinase activity
TK78_RS26910	COG2197	response regulator
TK78_RS26915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK78_RS26925	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TK78_RS26935	COG2193	ferroxidase activity
TK78_RS26940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TK78_RS26945	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TK78_RS26950	COG2815	serine threonine protein kinase
TK78_RS26950	COG0515	serine threonine protein kinase
TK78_RS26955	COG2022	thiamine diphosphate biosynthetic process
TK78_RS26965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TK78_RS26965	COG2022	thiamine diphosphate biosynthetic process
TK78_RS26985	COG0352	thiamine-phosphate diphosphorylase activity
TK78_RS27020	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
TK78_RS27030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TK78_RS27050	COG0714	Associated with various cellular activities
TK78_RS27060	COG0275	rRNA processing
TK78_RS27070	COG0768	penicillin binding
TK78_RS27075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TK78_RS27085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TK78_RS27090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TK78_RS27100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TK78_RS27125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TK78_RS27130	COG1799	cell septum assembly
TK78_RS27140	COG3599	regulation of cell shape
TK78_RS27145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TK78_RS27155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TK78_RS27200	COG0587	DNA-directed DNA polymerase activity
TK78_RS27210	COG1432	Conserved Protein
TK78_RS27250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TK78_RS27255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK78_RS27260	COG0131	Imidazoleglycerol-phosphate dehydratase
TK78_RS27265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TK78_RS27270	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TK78_RS27275	COG0251	oxidation-reduction process
TK78_RS27280	COG0107	imidazoleglycerol-phosphate synthase activity
TK78_RS27295	COG2508	Transcriptional regulator
TK78_RS27315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TK78_RS27320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK78_RS27340	COG0134	indole-3-glycerol-phosphate synthase activity
TK78_RS27350	COG0133	tryptophan synthase activity
TK78_RS27355	COG0159	tryptophan synthase activity
TK78_RS27365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TK78_RS27370	COG2301	Belongs to the HpcH HpaI aldolase family
TK78_RS27375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TK78_RS27380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK78_RS27410	COG0070	glutamate synthase
TK78_RS27410	COG0069	glutamate synthase activity
TK78_RS27410	COG0067	glutamate synthase
TK78_RS27420	COG0705	Rhomboid family
TK78_RS27440	COG1960	acyl-CoA dehydrogenase activity
TK78_RS27445	COG1960	acyl-CoA dehydrogenase activity
TK78_RS27450	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS27455	COG1309	transcriptional regulator
TK78_RS27460	COG0183	Belongs to the thiolase family
TK78_RS27465	COG1278	Cold shock
TK78_RS27490	COG1024	Enoyl-CoA hydratase
TK78_RS27495	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS27530	COG1605	Chorismate mutase
TK78_RS27530	COG0287	Prephenate dehydrogenase
TK78_RS27555	COG0659	secondary active sulfate transmembrane transporter activity
TK78_RS27575	COG0737	Belongs to the 5'-nucleotidase family
TK78_RS27630	COG2050	protein possibly involved in aromatic compounds catabolism
TK78_RS27660	COG1643	Atp-dependent helicase
TK78_RS27665	COG2226	methyltransferase
TK78_RS27685	COG0237	dephospho-CoA kinase activity
TK78_RS27710	COG2226	methyltransferase
TK78_RS27720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TK78_RS27740	COG0436	Aminotransferase
TK78_RS27755	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TK78_RS27760	COG2313	pseudouridylate synthase activity
TK78_RS27785	COG0584	glycerophosphoryl diester phosphodiesterase
TK78_RS27795	COG0556	nucleotide-excision repair
TK78_RS27825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TK78_RS27850	COG0322	excinuclease ABC activity
TK78_RS27855	COG1660	Displays ATPase and GTPase activities
TK78_RS27860	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TK78_RS27865	COG1481	regulation of sporulation
TK78_RS27870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TK78_RS27875	COG0126	phosphoglycerate kinase activity
TK78_RS27880	COG0149	triose-phosphate isomerase activity
TK78_RS27885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TK78_RS27895	COG0166	Belongs to the GPI family
TK78_RS27920	COG0363	glucosamine-6-phosphate deaminase activity
TK78_RS27935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TK78_RS27945	COG0109	protoheme IX farnesyltransferase activity
TK78_RS27985	COG0719	Fe-S assembly protein
TK78_RS27995	COG0396	ATPase activity
TK78_RS28000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TK78_RS28005	COG0822	iron-sulfur transferase activity
TK78_RS28010	COG2151	metal-sulfur cluster biosynthetic enzyme
TK78_RS28030	COG3226	Transcriptional regulator
TK78_RS28045	COG2171	N-acyltransferase activity
TK78_RS28050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TK78_RS28080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK78_RS28085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TK78_RS28105	COG0768	penicillin binding
TK78_RS28110	COG2197	response regulator
TK78_RS28115	COG4585	Histidine kinase
TK78_RS28130	COG1414	Transcriptional regulator
TK78_RS28160	COG1846	Transcriptional regulator
TK78_RS28165	COG1902	pentaerythritol trinitrate reductase activity
TK78_RS28195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TK78_RS28220	COG1797	cobyrinic acid a,c-diamide synthase activity
TK78_RS28235	COG1492	cobalamin metabolic process
TK78_RS28240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TK78_RS28255	COG0235	Class ii aldolase
TK78_RS28280	COG0488	(ABC) transporter
TK78_RS28330	COG3387	PFAM Glycoside hydrolase 15-related
TK78_RS28345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TK78_RS28345	COG1199	ATP-dependent helicase activity
TK78_RS28365	COG1404	Belongs to the peptidase S8 family
TK78_RS28380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK78_RS28385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TK78_RS28400	COG2261	transglycosylase associated protein
TK78_RS28405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TK78_RS28420	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS28425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TK78_RS28435	COG2186	Transcriptional regulator
TK78_RS28455	COG0560	Phosphoserine phosphatase
TK78_RS28455	COG3830	Belongs to the UPF0237 family
TK78_RS28460	COG0842	Transport permease protein
TK78_RS28460	COG1716	ATPase activity
TK78_RS28460	COG1131	(ABC) transporter
TK78_RS28470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TK78_RS28485	COG2197	response regulator
TK78_RS28500	COG1119	ATPase activity
TK78_RS28525	COG1881	PFAM PEBP family protein
TK78_RS28535	COG2094	Belongs to the DNA glycosylase MPG family
TK78_RS28570	COG0647	UMP catabolic process
TK78_RS28575	COG1120	ATPase activity
TK78_RS28595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TK78_RS28600	COG0497	DNA recombination
TK78_RS28615	COG0789	Transcriptional regulator
TK78_RS28625	COG3387	PFAM Glycoside hydrolase 15-related
TK78_RS28630	COG0504	CTP synthase activity
TK78_RS28635	COG0494	nUDIX hydrolase
TK78_RS28645	COG0686	Belongs to the AlaDH PNT family
TK78_RS28660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TK78_RS28665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TK78_RS28670	COG1187	pseudouridine synthase activity
TK78_RS28685	COG0494	nUDIX hydrolase
TK78_RS28730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TK78_RS28740	COG1160	GTP binding
TK78_RS28755	COG0438	transferase activity, transferring glycosyl groups
TK78_RS28775	COG0671	phosphoesterase, PA-phosphatase related
TK78_RS28780	COG0477	Major facilitator Superfamily
TK78_RS28785	COG1960	acyl-CoA dehydrogenase activity
TK78_RS28790	COG1799	cell septum assembly
TK78_RS28800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TK78_RS28805	COG0765	amino acid transport
TK78_RS28820	COG1126	abc transporter atp-binding protein
TK78_RS28825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TK78_RS28830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS28835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS28865	COG0641	radical SAM
TK78_RS28905	COG4565	transcriptional regulatory protein
TK78_RS28925	COG0346	lactoylglutathione lyase activity
TK78_RS28940	COG1725	Transcriptional regulator
TK78_RS28950	COG2755	lipolytic protein G-D-S-L family
TK78_RS28960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TK78_RS28970	COG2188	Transcriptional regulator
TK78_RS28975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TK78_RS28980	COG1309	transcriptional regulator
TK78_RS28985	COG0243	molybdopterin cofactor binding
TK78_RS28990	COG2851	Citrate transporter
TK78_RS29000	COG2318	DinB family
TK78_RS29015	COG2326	polyphosphate kinase activity
TK78_RS29025	COG0640	Transcriptional regulator
TK78_RS29035	COG1960	acyl-CoA dehydrogenase activity
TK78_RS29055	COG0789	Transcriptional regulator
TK78_RS29070	COG3876	Protein conserved in bacteria
TK78_RS29075	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS29080	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS29090	COG4935	Belongs to the peptidase S8 family
TK78_RS29090	COG2234	aminopeptidase activity
TK78_RS29095	COG1960	acyl-CoA dehydrogenase activity
TK78_RS29105	COG4948	Mandelate Racemase Muconate Lactonizing
TK78_RS29120	COG2149	membrane
TK78_RS29125	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TK78_RS29130	COG3573	Dehydrogenase
TK78_RS29155	COG3265	gluconokinase activity
TK78_RS29160	COG2186	Transcriptional regulator
TK78_RS29175	COG0564	pseudouridine synthase activity
TK78_RS29185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK78_RS29215	COG0667	Aldo Keto reductase
TK78_RS29220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS29230	COG0598	Magnesium transport protein CorA
TK78_RS29250	COG0215	cysteine-tRNA ligase activity
TK78_RS29265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS29270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TK78_RS29275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TK78_RS29280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TK78_RS29285	COG1414	Transcriptional regulator
TK78_RS29290	COG1410	methionine synthase
TK78_RS29290	COG0646	methionine synthase
TK78_RS29295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TK78_RS29300	COG4166	transmembrane transport
TK78_RS29305	COG2197	response regulator
TK78_RS29315	COG0517	IMP dehydrogenase activity
TK78_RS29315	COG1994	Peptidase M50
TK78_RS29340	COG1222	aaa ATPase
TK78_RS29345	COG4122	O-methyltransferase activity
TK78_RS29360	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TK78_RS29365	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TK78_RS29370	COG1609	Transcriptional regulator
TK78_RS29380	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TK78_RS29385	COG0545	Peptidyl-prolyl cis-trans isomerase
TK78_RS29395	COG2378	regulation of single-species biofilm formation
TK78_RS29415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TK78_RS29420	COG0805	protein transport
TK78_RS29455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TK78_RS29460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TK78_RS29505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TK78_RS29510	COG0517	IMP dehydrogenase activity
TK78_RS29510	COG4175	Glycine betaine
TK78_RS29560	COG1404	Belongs to the peptidase S8 family
TK78_RS29570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TK78_RS29580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TK78_RS29585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TK78_RS29590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TK78_RS29595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TK78_RS29600	COG5002	protein histidine kinase activity
TK78_RS29605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TK78_RS29610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK78_RS29610	COG0072	phenylalanine-tRNA ligase activity
TK78_RS29680	COG0515	serine threonine protein kinase
TK78_RS29695	COG1649	PFAM Uncharacterised BCR, COG1649
TK78_RS29705	COG0697	spore germination
TK78_RS29770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS29785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS29795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TK78_RS29800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TK78_RS29805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TK78_RS29810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TK78_RS29815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TK78_RS29820	COG1438	arginine binding
TK78_RS29835	COG0137	argininosuccinate synthase activity
TK78_RS29840	COG0165	Argininosuccinate lyase
TK78_RS29850	COG3973	AAA domain
TK78_RS29860	COG0477	Major facilitator Superfamily
TK78_RS29900	COG2011	ABC-type metal ion transport system permease component
TK78_RS29905	COG1464	Belongs to the NlpA lipoprotein family
TK78_RS29920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TK78_RS29925	COG1648	precorrin-2 dehydrogenase activity
TK78_RS29925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TK78_RS29980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK78_RS29990	COG0454	-acetyltransferase
TK78_RS29990	COG0456	acetyltransferase
TK78_RS30035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TK78_RS30050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TK78_RS30075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TK78_RS30080	COG1560	Kdo2-lipid A biosynthetic process
TK78_RS30085	COG0438	transferase activity, transferring glycosyl groups
TK78_RS30095	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TK78_RS30100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TK78_RS30105	COG0217	transcriptional regulatory protein
TK78_RS30110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TK78_RS30115	COG0632	four-way junction helicase activity
TK78_RS30120	COG2255	four-way junction helicase activity
TK78_RS30130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK78_RS30135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK78_RS30140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TK78_RS30145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TK78_RS30150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TK78_RS30160	COG1196	nuclear chromosome segregation
TK78_RS30175	COG0124	histidyl-tRNA synthetase
TK78_RS30180	COG2197	response regulator
TK78_RS30185	COG4585	Histidine kinase
TK78_RS30195	COG1131	(ABC) transporter
TK78_RS30215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TK78_RS30235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK78_RS30240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TK78_RS30250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TK78_RS30255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TK78_RS30260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TK78_RS30265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TK78_RS30275	COG0006	proline dipeptidase activity
TK78_RS30280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TK78_RS30285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TK78_RS30295	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TK78_RS30300	COG0540	Belongs to the ATCase OTCase family
TK78_RS30305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TK78_RS30315	COG0505	Belongs to the CarA family
TK78_RS30320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TK78_RS30325	COG0167	dihydroorotate dehydrogenase activity
TK78_RS30330	COG0284	orotidine-5'-phosphate decarboxylase activity
TK78_RS30345	COG1758	RNA polymerase activity
TK78_RS30355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TK78_RS30360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TK78_RS30370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TK78_RS30380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TK78_RS30385	COG2390	Transcriptional regulator
TK78_RS30400	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS30410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TK78_RS30430	COG2233	PERMEase
TK78_RS30435	COG0738	Major facilitator superfamily
TK78_RS30440	COG1940	carbohydrate kinase activity
TK78_RS30465	COG3201	nicotinamide mononucleotide transporter
TK78_RS30470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK78_RS30470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK78_RS30475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TK78_RS30480	COG0140	phosphoribosyl-ATP diphosphatase activity
TK78_RS30485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TK78_RS30530	COG2318	DinB family
TK78_RS30540	COG1960	acyl-CoA dehydrogenase activity
TK78_RS30565	COG1216	Glycosyl transferase, family 2
TK78_RS30580	COG2270	Major facilitator Superfamily
TK78_RS30590	COG2364	Membrane
TK78_RS30660	COG2018	Roadblock/LC7 domain
TK78_RS30675	COG2732	(Barnase) inhibitor
TK78_RS30695	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TK78_RS30710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TK78_RS30720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TK78_RS30755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TK78_RS30775	COG1716	ATPase activity
TK78_RS30795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TK78_RS30805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK78_RS30805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK78_RS30895	COG3851	Histidine kinase
TK78_RS30900	COG2197	response regulator
TK78_RS30905	COG1695	Transcriptional regulator
TK78_RS30945	COG0697	spore germination
TK78_RS30950	COG0583	DNA-binding transcription factor activity
TK78_RS30985	COG0789	Transcriptional regulator
TK78_RS30995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TK78_RS31000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TK78_RS31015	COG0546	phosphoglycolate phosphatase activity
TK78_RS31025	COG0604	alcohol dehydrogenase
TK78_RS31025	COG3321	synthase
TK78_RS31030	COG0604	alcohol dehydrogenase
TK78_RS31030	COG3321	synthase
TK78_RS31045	COG3321	synthase
TK78_RS31045	COG0604	alcohol dehydrogenase
TK78_RS31050	COG0604	alcohol dehydrogenase
TK78_RS31050	COG3321	synthase
TK78_RS31055	COG2162	N-hydroxyarylamine O-acetyltransferase activity
TK78_RS31080	COG0022	dehydrogenase e1 component
TK78_RS31085	COG0508	dehydrogenase complex catalyzes the overall conversion of
TK78_RS31095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TK78_RS31115	COG0778	Nitroreductase
TK78_RS31120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TK78_RS31145	COG0151	Belongs to the GarS family
TK78_RS31150	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TK78_RS31160	COG0602	queuosine metabolic process
TK78_RS31165	COG0302	gtp cyclohydrolase
TK78_RS31175	COG2175	clavaminate synthase activity
TK78_RS31210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TK78_RS31225	COG2318	DinB family
TK78_RS31275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TK78_RS31280	COG2226	methyltransferase
TK78_RS31285	COG0243	molybdopterin cofactor binding
TK78_RS31300	COG1968	undecaprenyl-diphosphatase activity
TK78_RS31320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TK78_RS31360	COG2409	Drug exporters of the RND superfamily
TK78_RS31370	COG4585	Histidine kinase
TK78_RS31375	COG2197	response regulator
TK78_RS31395	COG1832	CoA-binding protein
TK78_RS31400	COG1739	Uncharacterized protein family UPF0029
TK78_RS31405	COG0420	3'-5' exonuclease activity
TK78_RS31410	COG0419	ATPase involved in DNA repair
TK78_RS31415	COG1522	sequence-specific DNA binding
TK78_RS31440	COG0626	cystathionine gamma-synthase activity
TK78_RS31465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TK78_RS31480	COG1595	DNA-templated transcription, initiation
TK78_RS31485	COG2188	Transcriptional regulator
TK78_RS31490	COG1940	carbohydrate kinase activity
TK78_RS31495	COG2197	response regulator
TK78_RS31505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TK78_RS31530	COG2226	methyltransferase
TK78_RS31535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TK78_RS31540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TK78_RS31545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TK78_RS31550	COG0156	8-amino-7-oxononanoate synthase activity
TK78_RS31570	COG0583	DNA-binding transcription factor activity
TK78_RS31575	COG1280	lysine exporter protein (LysE YggA)
TK78_RS31590	COG0740	serine-type endopeptidase activity
TK78_RS31605	COG1309	transcriptional regulator
TK78_RS31610	COG0831	urea catabolic process
TK78_RS31615	COG0832	Belongs to the urease beta subunit family
TK78_RS31620	COG0804	urea catabolic process
TK78_RS31630	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TK78_RS31635	COG0829	nickel cation binding
TK78_RS31650	COG0204	Acyl-transferase
TK78_RS31660	COG0205	6-phosphofructokinase activity
TK78_RS31665	COG3442	glutamine amidotransferase
TK78_RS31675	COG0242	peptide deformylase activity
TK78_RS31685	COG1960	acyl-CoA dehydrogenase activity
TK78_RS31690	COG0386	Belongs to the glutathione peroxidase family
TK78_RS31725	COG1946	Acyl-CoA thioesterase
TK78_RS31740	COG1793	dna ligase
TK78_RS31760	COG1132	(ABC) transporter
TK78_RS31765	COG1132	(ABC) transporter
TK78_RS31775	COG0277	FAD linked oxidase domain protein
TK78_RS31780	COG1846	Transcriptional regulator
TK78_RS31785	COG1132	(ABC) transporter
TK78_RS31795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TK78_RS31805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS31815	COG1116	anion transmembrane transporter activity
TK78_RS31820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TK78_RS31895	COG0464	growth
TK78_RS31905	COG1674	ftsk spoiiie
TK78_RS31925	COG4842	Belongs to the WXG100 family
TK78_RS31960	COG1309	transcriptional regulator
TK78_RS31965	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS31975	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK78_RS31975	COG1902	pentaerythritol trinitrate reductase activity
TK78_RS31985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TK78_RS32005	COG0385	Bile acid
TK78_RS32010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TK78_RS32025	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TK78_RS32050	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
TK78_RS32065	COG1891	lyase activity
TK78_RS32075	COG2160	L-arabinose isomerase activity
TK78_RS32085	COG1609	Transcriptional regulator
TK78_RS32100	COG4214	carbohydrate transport
TK78_RS32140	COG4592	Periplasmic binding protein
TK78_RS32150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS32155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS32165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TK78_RS32200	COG1174	glycine betaine transport
TK78_RS32205	COG1174	glycine betaine transport
TK78_RS32215	COG2986	histidine ammonia-lyase
TK78_RS32230	COG2080	2 iron, 2 sulfur cluster binding
TK78_RS32235	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TK78_RS32240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TK78_RS32265	COG2890	protein-(glutamine-N5) methyltransferase activity
TK78_RS32280	COG1335	isochorismatase
TK78_RS32340	COG0515	serine threonine protein kinase
TK78_RS32340	COG2815	serine threonine protein kinase
TK78_RS32355	COG0542	response to heat
TK78_RS32390	COG0515	serine threonine protein kinase
TK78_RS32390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK78_RS32410	COG0402	S-adenosylhomocysteine deaminase activity
TK78_RS32415	COG1228	amidohydrolase
TK78_RS32430	COG2835	tetraacyldisaccharide 4'-kinase activity
TK78_RS32450	COG4981	capsule polysaccharide biosynthetic process
TK78_RS32480	COG1012	belongs to the aldehyde dehydrogenase family
TK78_RS32485	COG0174	glutamine synthetase
TK78_RS32495	COG0531	amino acid
TK78_RS32500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TK78_RS32535	COG1253	flavin adenine dinucleotide binding
TK78_RS32565	COG0667	Aldo Keto reductase
TK78_RS32570	COG2815	serine threonine protein kinase
TK78_RS32570	COG0515	serine threonine protein kinase
TK78_RS32595	COG2706	6-phosphogluconolactonase activity
TK78_RS32610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TK78_RS32655	COG0671	phosphoesterase, PA-phosphatase related
TK78_RS32675	COG0584	glycerophosphoryl diester phosphodiesterase
TK78_RS32720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TK78_RS32750	COG1940	carbohydrate kinase activity
TK78_RS32760	COG1660	Displays ATPase and GTPase activities
TK78_RS32775	COG0445	tRNA wobble uridine modification
TK78_RS32790	COG4585	Histidine kinase
TK78_RS32795	COG2197	response regulator
TK78_RS32805	COG2223	nitrite transmembrane transporter activity
TK78_RS32810	COG1940	carbohydrate kinase activity
TK78_RS32850	COG0702	epimerase
TK78_RS32865	COG1349	DNA-binding transcription factor activity
TK78_RS32875	COG0464	growth
TK78_RS32935	COG0395	ABC-type sugar transport system, permease component
TK78_RS32940	COG1175	transmembrane transport
TK78_RS32960	COG1609	Transcriptional regulator
TK78_RS33015	COG2264	protein methyltransferase activity
TK78_RS33025	COG1132	(ABC) transporter
TK78_RS33030	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS33035	COG0328	RNA-DNA hybrid ribonuclease activity
TK78_RS33085	COG0842	Transport permease protein
TK78_RS33085	COG1131	(ABC) transporter
TK78_RS33085	COG1716	ATPase activity
TK78_RS33135	COG1879	ABC-type sugar transport system periplasmic component
TK78_RS33140	COG1129	ABC transporter
TK78_RS33150	COG1172	Belongs to the binding-protein-dependent transport system permease family
TK78_RS33155	COG1609	Transcriptional regulator
TK78_RS33170	COG3226	Transcriptional regulator
TK78_RS33190	COG1874	Beta-galactosidase
TK78_RS33190	COG0366	Alpha amylase catalytic
TK78_RS33200	COG0187	DNA topoisomerase II activity
TK78_RS33215	COG0789	Transcriptional regulator
TK78_RS33225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS33230	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS33235	COG1120	ATPase activity
TK78_RS33265	COG1295	ribonuclease BN
TK78_RS33265	COG1959	2 iron, 2 sulfur cluster binding
TK78_RS33310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TK78_RS33335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS33340	COG1120	ATPase activity
TK78_RS33355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TK78_RS33360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TK78_RS33370	COG0824	Thioesterase
TK78_RS33370	COG1250	3-hydroxyacyl-CoA dehydrogenase
TK78_RS33375	COG1250	3-hydroxyacyl-CoA dehydrogenase
TK78_RS33380	COG3246	L-lysine catabolic process to acetate
TK78_RS33385	COG1309	transcriptional regulator
TK78_RS33390	COG1191	sigma factor activity
TK78_RS33420	COG0488	(ABC) transporter
TK78_RS33435	COG1461	Dihydroxyacetone kinase
TK78_RS33440	COG2376	Dihydroxyacetone kinase
TK78_RS33460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS33520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TK78_RS33520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TK78_RS33545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TK78_RS33560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TK78_RS33565	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS33570	COG1302	Protein conserved in bacteria
TK78_RS33575	COG0587	DNA-directed DNA polymerase activity
TK78_RS33580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TK78_RS33600	COG1131	(ABC) transporter
TK78_RS33605	COG3559	Exporter of polyketide antibiotics
TK78_RS33640	COG0745	RESPONSE REGULATOR receiver
TK78_RS33645	COG5002	protein histidine kinase activity
TK78_RS33660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS33665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS33670	COG1120	ATPase activity
TK78_RS33675	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TK78_RS33680	COG1132	(ABC) transporter
TK78_RS33690	COG1132	(ABC) transporter
TK78_RS33700	COG0488	(ABC) transporter
TK78_RS33715	COG2382	esterase
TK78_RS33725	COG0148	phosphopyruvate hydratase activity
TK78_RS33740	COG1470	cell adhesion involved in biofilm formation
TK78_RS33760	COG3845	ABC transporter
TK78_RS33795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TK78_RS33815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TK78_RS33825	COG1535	isochorismatase
TK78_RS33825	COG3433	isochorismatase activity
TK78_RS33830	COG1535	isochorismatase
TK78_RS33830	COG3433	isochorismatase activity
TK78_RS33835	COG1021	2,3-dihydroxybenzoate-AMP ligase
TK78_RS33840	COG1169	isochorismate synthase
TK78_RS33845	COG1028	Short-chain dehydrogenase reductase Sdr
TK78_RS33850	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK78_RS33855	COG2382	esterase
TK78_RS33860	COG0477	Major facilitator Superfamily
TK78_RS33870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TK78_RS33880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK78_RS33885	COG1120	ATPase activity
TK78_RS33910	COG2365	Tyrosine phosphatase family
TK78_RS33965	COG2080	2 iron, 2 sulfur cluster binding
TK78_RS33970	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TK78_RS33975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TK78_RS33990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TK78_RS34010	COG2066	Belongs to the glutaminase family
TK78_RS34010	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TK78_RS34015	COG2356	endonuclease I
TK78_RS34030	COG2813	Specifically methylates the guanine in position
TK78_RS34035	COG1960	acyl-CoA dehydrogenase activity
TK78_RS34055	COG0515	serine threonine protein kinase
TK78_RS34075	COG2070	2-Nitropropane dioxygenase
TK78_RS34085	COG0318	PFAM AMP-dependent synthetase and ligase
TK78_RS34095	COG0765	amino acid transport
TK78_RS34100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TK78_RS34120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TK78_RS34120	COG0515	serine threonine protein kinase
TK78_RS34130	COG1024	Enoyl-CoA hydratase
TK78_RS34160	COG1309	transcriptional regulator
TK78_RS34190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TK78_RS34195	COG0254	rRNA binding
TK78_RS34225	COG2318	DinB family
TK78_RS34280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TK78_RS34290	COG1105	Belongs to the carbohydrate kinase PfkB family
TK78_RS34295	COG1349	DNA-binding transcription factor activity
TK78_RS34310	COG0596	Alpha beta hydrolase
TK78_RS34315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TK78_RS34355	COG2318	DinB family
TK78_RS34405	COG0702	epimerase
TK78_RS34420	COG1064	alcohol dehydrogenase
TK78_RS34430	COG0277	FAD linked oxidase domain protein
TK78_RS34435	COG1309	transcriptional regulator
TK78_RS34475	COG1764	response to oxidative stress
TK78_RS34480	COG1846	Transcriptional regulator
TK78_RS34490	COG0477	Major facilitator Superfamily
TK78_RS34510	COG0477	Major facilitator Superfamily
TK78_RS34525	COG5297	Belongs to the glycosyl hydrolase family 6
TK78_RS34535	COG1073	alpha beta
TK78_RS34535	COG2226	methyltransferase
TK78_RS34540	COG4941	Belongs to the sigma-70 factor family
TK78_RS34545	COG3795	YCII-related domain
TK78_RS34740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TK78_RS34860	COG4974	Belongs to the 'phage' integrase family